Radioiodine Therapy 
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Thyroid arterial embolization as a therapeutic option for hyperthyroidism: a case series
CONCLUSION: Embolization of three dominant thyroid arteries with polyvinyl alcohol allowed reduction in goiter volume in the three patients who completed the protocol, but was not effective to control hyperthyroidism. (Source: Radiologia Brasileira)
Source: Radiologia Brasileira - May 11, 2013 Category: Radiology Source Type: research
New guidance on radioiodine therapy use after radiographic studies
Researchers have provided new evidence that could act as a guide for the use of radioiodine therapy after patients have undergone radiographic imaging studies that use iodine as a contrasting agent. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - April 30, 2013 Category: Cancer & Oncology Source Type: news
Radioiodine therapy in elderly patients with subclinical hyperthyroidism due to non-voluminous nodular goiter and its effect on bone metabolism
CONCLUSIONS: In elderly patients with SCH and non-voluminous goiter, radioiodine not preceded by ATDs is a safe and effective therapeutic alternative. Resolution of SCH has beneficial effects on BMD in postmenopausal women with osteopenia.OBJETIVO: Avaliar a terapia com 131I em idosos com hipertireoidismo subclínico (HSC) por doença nodular que não receberam drogas antitireoidianas (DATs) e o efeito no metabolismo ósseo. SUJEITOS E MÉTODOS: Trinta e seis pacientes com TSH ≤ 0,1 mUI/L e bócio não volumoso (< 60 cm³) foram estudados. Dezessete mulheres com osteopenia foram submetidas à avaliação da densidade min...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - April 13, 2013 Category: Endocrinology Source Type: research
Preablation 131-I Scans With SPECT/CT in Postoperative Thyroid Cancer Patients: What Is the Impact on Staging?
Conclusions:Dx scans detected regional metastases in 35% of patients, and distant metastases in 8% of patients. Information acquired with Dx scans changed staging in 4% of younger, and 25% of older patients. Preablation scans with SPECT/CT contribute to staging of thyroid cancer. Identification of regional and distant metastases prior to radioiodine therapy has significant potential to alter patient management.
PMID: 23430789 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2013 Category: Endocrinology Authors: Avram AM, Fig LM, Frey KA, Gross MD, Wong KK Tags: J Clin Endocrinol Metab Source Type: research
Advantages of surgical extirpation in addition to radioiodine therapy in differentiated thyroid carcinoma patients with a solitary large-volume skeletal metastasis with small-volume oligometastatic disease in the rest of the whole body
Sandip Basu, Chaitanya R Borde, Amit AbhyankarJournal of Cancer Research and Therapeutics 2012 8(4):656-657 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 29, 2013 Category: Cancer & Oncology Authors: Sandip BasuChaitanya R BordeAmit Abhyankar Source Type: research
[Incorporation monitoring of employees of a radioiodine therapy ward - Is incorporation monitoring required for routine? Ist im Routinebetrieb eine Inkorporationsüberwachung erforderlich?]
Conclusions: To estimate the aed caused by incorporation of 131 I it has to be subdivided for the different requirements in the diverse fields of activity of the employees. Regarding those who spend most of their time nearby the patient an incorporation monitoring by the authority might be required. The 131 I incorporation factor from the guideline (10⁻⁶) can be reduced by a factor of 10. For 99m Tc and 18 F an incorporation factor of 10⁻⁷ is accepted.
PMID: 23348688 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - January 25, 2013 Category: Radiology Authors: Happel C, Kratzel U, Selkinski I, Bockisch B, Etzel M, Korkusuz H, Sauter B, Staudt J, von Müller F, Grünwald F, Kranert WT Tags: Nuklearmedizin Source Type: research
MicroRNAs miR-146-5p and let-7f as prognostic tools for aggressive papillary thyroid carcinoma: a case report
In this study, we evaluated the miR146b-5p and let-7f status in a young male patient with aggressive, BRAFT1799A-positive papillary thyroid carcinoma, with extensive lymph node metastases and short-time recurrence. The analysis of miR-146b-5p and let-7f expression revealed a distinct pattern from a cohort of PTC patients, suggesting caution in evaluating miRNA expression data as molecular markers of PTC diagnosis and prognosis. Arq Bras Endocrinol Metab. 2012;56(8):552-7O carcinoma papilífero (PTC) é o histotipo mais prevalente de câncer de tiroide. Cerca de 5% dos casos são refratários ao tratamento convencional e à...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 8, 2013 Category: Endocrinology Source Type: research
Update on Thyroid Cancer TreatmentUpdate on Thyroid Cancer Treatment
Thyroid cancer subtypes are often lethal and refractory to radioiodine therapy as well as most of the common chemotherapy drugs, but novel therapies are gaining momentum. . . Future Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 9, 2012 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Incremental Diagnostic Value of SPECT/CT with 131I Scintigraphy after Radioiodine Therapy in Patients with Well-differentiated Thyroid Carcinoma [Nuclear Medicine]
Conclusion:
SPECT/CT improved detection and localization of 131I accumulation in lymph node metastases and distant metastases, compared with whole-body scintigraphy.
© RSNA, 2012 (Source: Radiology)
Source: Radiology - November 21, 2012 Category: Radiology Authors: Maruoka, Y., Abe, K., Baba, S., Isoda, T., Sawamoto, H., Tanabe, Y., Sasaki, M., Honda, H. Tags: Nuclear Medicine Source Type: research
Assessment of Salivary Gland Dysfunction after Radioiodine Therapy for Thyroid Carcinoma Using Non-Contrast-Enhanced CT: The Significance of Changes in Volume and Attenuation of the Glands [HEAD & NECK]
CONCLUSIONS:
The reduction in volume of the parotid and submandibular glands and the increase in attenuation of the parotid gland on nonenhanced CT can be indicators of the grade of RIT-induced salivary dysfunction. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 15, 2012 Category: Radiology Authors: Nabaa, B., Takahashi, K., Sasaki, T., Okizaki, A., Aburano, T. Tags: HEAD & amp; NECK Source Type: research
Differentiated Thyroid Cancer in childhood.
Abstract
Thyroid carcinoma is a rare disease in children, and is mostly of the papillary histological type. Lymph node metastases are frequent at diagnosis, being present in 23 to 74% of the cases and can reveal the cancer in about one fourth of cases. Lung metastases are present at initial diagnosis in 6 to 20% of cases. The main known risk factor for thyroid cancer is a previous history of radiation exposure. Treatment includes surgery with total thyroidectomy and lymph node dissection and radioiodine therapy in case of extensive disease and distant metastases. Life-long thyroxine treatment is given to all patien...
Source: Bulletin du Cancer - November 12, 2012 Category: Cancer & Oncology Authors: Leboulleux S, Hartl D, Baudin E, Schlumberger M Tags: Bull Cancer Source Type: research
Serious jaundice and thyrotoxic myocardiopathy with atrial thrombus
We report a case of a 54-year-old white woman with hyperthyroidism caused by Graves's disease and jaundice despite methimazole suspension. Bilirubin fluctuated at high values, between 30.0 and 52.3 mg/dL, transaminases were slightly increased, on admission ALT = 46 U/L and AST = 87 U/L; coagulation indices and serum proteins were on the lower limit of the normal range with PT 68% and albumin = 2.5 g/dL. Serology for hepatitis was negative. After the first radioiodine therapy (RT), bilirubin reached its maximum, which coincided with the worst period of HF exacerbation. Bilirubin normalized 4 weeks after the second RT, with ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - October 31, 2012 Category: Endocrinology Source Type: research
In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator
and its cognate receptor, but not with disease‐free interval
ConclusionIn PTC, BRAFV600E induces uPA and uPAR expression. The latter, but not BRAFV600E, associates with advanced stages and shorter DFI. If confirmed in larger case studies, they may represent reliable prognostic markers for more accurate risk stratification and postoperative decision‐making in patients with PTC. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - October 5, 2012 Category: Endocrinology Authors: Salvatore Ulisse, Enke Baldini, Salvatore Sorrenti, Susi Barollo, Natalie Prinzi, Antonio Catania, Angela Nesca, Lucio Gnessi, Maria R. Pelizzo, Caterina Mian, Corrado Vito, Anna Calvanese, Silvio Palermo, Severino Persechino, Enrico Antoni, Massimino D'A Tags: Original Article Source Type: research
Sodium iodide symporter (NIS)-mediated radiovirotherapy of hepatocellular cancer using a conditionally replicating adenovirus
;ke, P S Holm
& C Spitzweg (Source: Gene Therapy)
Source: Gene Therapy - October 4, 2012 Category: Genetics & Stem Cells Authors: G K GrünwaldK KlutzM J WillhauckN SchwenkR Senekowitsch-SchmidtkeM SchwaigerC ZachB GökeP S HolmC Spitzweg Tags: hepatocellular cancer (HCC) α-fetoprotein (AFP) oncolytic adenovirus sodium iodide symporter (NIS) radioiodine therapy Source Type: research
Incremental Diagnostic Value of SPECT/CT with 131I Scintigraphy after Radioiodine Therapy in Patients with Well-differentiated Thyroid Carcinoma [Nuclear Medicine]
SPECT/CT improved the detection and localization of lymph node metastases and distant metastases, as compared with whole-body scintigraphy, and had a considerable effect on the management of patients with well-differentiated thyroid carcinoma. (Source: Continuous Publishing articles)
Source: Continuous Publishing articles - September 25, 2012 Category: Radiology Authors: Maruoka, Y., Abe, K., Baba, S., Isoda, T., Sawamoto, H., Tanabe, Y., Sasaki, M., Honda, H. Tags: Nuclear Medicine Source Type: research
Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line
Conclusions: ALA is a potential agent to increase NIS transcription in TPC-1. It could be used as an adjunctive agent to increase efficacy of radioiodine therapy if combined with a strategy to increase NIS protein trafficking to cell membrane. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - September 19, 2012 Category: Radiology Authors: Hyun-Jeung Choi, Tae Yong Kim, Sergio Ruiz-Llorente, Min Ji Jeon, Ji Min Han, Won Gu Kim, Young Kee Shong, Won Bae Kim Tags: Original Articles Source Type: research
Is lithium an effective adjunct therapy for radioiodine therapy for hyperthyroidism?
(Source: Clinical Endocrinology)
Source: Clinical Endocrinology - September 11, 2012 Category: Endocrinology Authors: Mark Vanderpump Tags: Commentary Source Type: research
Radioiodine Therapy in Benign Thyroid Diseases: Effects, Side Effects, and Factors Affecting Therapeutic Outcome.
Abstract
Radioiodine ((131)I) therapy of benign thyroid diseases was introduced 70 yr ago, and the patients treated since then are probably numbered in the millions. Fifty to 90 of hyperthyroid patients are cured within 1 yr after (131)I therapy. With longer follow-up, permanent hypothyroidism seems inevitable in Graves' disease, whereas this risk is much lower when treating toxic nodular goiter. The side effect causing most concern is the potential induction of ophthalmopathy in predisposed individuals. The response to (131)I therapy is to some extent related to the radiation dose. However, calculation of an exact...
Source: ENDOCR REV - September 7, 2012 Category: Endocrinology Authors: Bonnema SJ, Hegedüs L Tags: Endocr Rev Source Type: research
Short-term hypothyroidism in thyroid cancer patients and cognitive-motor performance relevant for driving
Summary: Context: In patients with differentiated thyroid carcinoma (DTC) who, after thyroidectomy, are to receive radioiodine therapy or diagnostics, a strong TSH stimulus is necessary. Traditionally, this is induced by thyroid hormone withdrawal (THW) over a period of 4–5weeks; alternatively thyroid hormone replacement therapy is continued and recombinant human thyrotropin (rhTSH) is administered. During the hypothyroid state due to THW, patients often report mood disturbances and physical complaints but also an impairment of performance during attention demanding tasks.Objective: Based on physiological, self-report an...
Source: Psychoneuroendocrinology - August 30, 2012 Category: Psychiatry Authors: Ernst Lodemann, Andreas Bockisch, Rainer Görges Tags: Articles Source Type: research
Clinical Outcomes Following Empiric Radioiodine Therapy in Patients with Structurally Identifiable Metastatic Follicular Cell–Derived Thyroid Carcinoma with Negative Diagnostic But Positive Post-Therapy 131I Whole-Body Scans
Thyroid Sep 2012, Vol. 22, No. 9: 877-883. (Source: Thyroid)
Source: Thyroid - August 27, 2012 Category: Endocrinology Tags: article Source Type: research
Re-induction of cell differentiation and 131I uptake in dedifferentiated FTC-133 cell line by TSHR gene transfection
This study aimed to test the therapeutic potential of TSHR in dedifferentiated DTC by gene transfection in order to restore cell differentiation and radioiodine uptake.Methods: Dedifferentiated FTC-133 (dFTC-133) cells were obtained by monoclonal culture of FTC-133 cell line after 131I radiation. Recombinant plasmid pcDNA3.1-hTSHR was transfected into dFTC-133 cells by using Lipofectamine 2000 reagent. Immunofluorescence analysis was carried out to confirm TSHR expression and its location. Radioiodine uptake assay was thereafter investigated. mRNAs and proteins of TSHR and other thyroid differentiated markers were detected...
Source: Nuclear Medicine and Biology - August 14, 2012 Category: Radiology Authors: Fang Feng, Hui Wang, Shasha Hou, Hongliang Fu Tags: Original Articles Source Type: research
[Measurement of ocular lens ionizing radiation exposure after radioiodine therapy].
CONCLUSION: The results show that there exists a low risk for radiation cataract in a nuclear medicine therapy unit. After serial radioiodine therapies radiation-induced lens opacity cannot be expected.
PMID: 22395665 [PubMed - in process] (Source: Nuklearmedizin)
Source: Nuklearmedizin - August 11, 2012 Category: Radiology Authors: Andreeff M, Claussnitzer J, Oehme L, Freudenberg R, Kotzerke J Tags: Nuklearmedizin Source Type: research
[Radiologic and nuclear medicine diagnosis and therapy of thyroid disorders : Part II: Malignant thyroid diseases.]
[Radiologic and nuclear medicine diagnosis and therapy of thyroid disorders : Part II: Malignant thyroid diseases.]
Radiologe. 2012 Aug 11;
Authors: Zechmann CM, Haufe S
Abstract
Malignant thyroid diseases have increased in recent years. The distinction between differentiated and non-differentiated thyroid carcinoma is essential for therapy and follow-up. The frequently diagnosed papillary and follicular thyroid carcinomas are differentiated and have a good prognosis. Clinical symptoms are relatively unspecific, however imaging and laboratory testing can often provide evidence for diagnosis of thyroid carci...
Source: Der Radiologe - August 11, 2012 Category: Radiology Authors: Zechmann CM, Haufe S Tags: Radiologe Source Type: research
Prognostic implication of thyroglobulin and quantified whole body scan after initial radioiodine therapy on early prediction of ablation and clinical response for the patients with differentiated thyroid cancer
Conclusions The thyroglobulin and quantified cervical uptake in whole body scan are significant predictors for the successful ablation
and disease-free status after follow-up.
Content Type Journal ArticleCategory Original articlePages 1-10DOI 10.1007/s12149-012-0640-1Authors
Ilhan Lim, Department of Nuclear Medicine, Korea Cancer Center Hospital, Seoul, KoreaSeok-ki Kim, Department of Nuclear Medicine, Research Institute and Hospital, National Cancer Center, 809 Madu Ilsan Goyang, Goyang, Gyeonggi 411-769, KoreaSeung-sik Hwang, Research Institute for National Cancer Control and Evaluation, National C...
Source: Annals of Nuclear Medicine - August 7, 2012 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: research
Correlation between thyroid volume and humoral thyroid autoimmunity after radioiodine therapy in Graves' disease.
CONCLUSIONS: 1. Decrease of thyroid gland volume after radioiodine therapy is followed by a significant decrease of the level of TRAb after 18-36 months. 2. TRAb concentration is positively correlated with thyroid gland volume. 3. Percentage reduction of TRAb is not correlated with percentage reduction of thyroid volume.
PMID: 22378091 [PubMed - indexed for MEDLINE] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - August 7, 2012 Category: Endocrinology Authors: Sawicka N, Sowiński J Tags: Endokrynol Pol Source Type: research
An easy schedule for postsurgical radioiodine administration in newly diagnosed differentiated thyroid carcinoma patients
ConclusionsQoL scores were not affected by TSH levels as absolute values. A longer time to obtain TSH≥30 mIU/L was positively correlated with worse scores of QoL. We suggest 3 weeks without therapy can be used as an easy schedule in patients who undergo TT for DTC.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - August 7, 2012 Category: Endocrinology Authors: Gelsy Arianna Lupoli, Maria Rita Poggiano, Annalisa Panico, Luciana Granieri, Roberta Lupoli, Marianna Cacciapuoti, Giovanni Lupoli Tags: Original Article Source Type: research
Pioglitazone therapy in progressive differentiated thyroid carcinoma.
Conclusion: Pioglitazone revealed some positive effects in radioiodine negative and progressive DTC patients but it did not fulfill the expectations given by the results of rosiglitazone therapy.
PMID: 22532159 [PubMed - in process] (Source: Nuklearmedizin)
Source: Nuklearmedizin - August 6, 2012 Category: Radiology Authors: Rosenbaum-Krumme SJ, Bockisch A, Nagarajah J Tags: Nuklearmedizin Source Type: research
Modification of a motel-type room to accommodate patients receiving radioiodine therapy: reduction of environmental exposure.
Modification of a motel-type room to accommodate patients receiving radioiodine therapy: reduction of environmental exposure.
Health Phys. 2012 Aug;103(2 Suppl 3):S131-5
Authors: Pickering CA, Dykes JN, Domingo MT, Patricko J, Yamauchi DM, Williams LE
Abstract
ABSTRACT: Patients receiving I-based therapies are generally restricted in leaving the medical institution. In the U.S., the U.S. Nuclear Regulatory Commission (U.S. NRC) has developed the rule that a ≤7 mR h reading at 1 m from the patient (or 33 mCi) is sufficient to allow unrestricted release. Because of home situations and other constraints, it ...
Source: Health Physics - August 1, 2012 Category: Physics Authors: Pickering CA, Dykes JN, Domingo MT, Patricko J, Yamauchi DM, Williams LE Tags: Health Phys Source Type: research
Clinical Outcomes Following Empiric Radioiodine Therapy in Patients with Structurally Identifiable Metastatic Follicular Cell–Derived Thyroid Carcinoma with Negative Diagnostic, But Positive Post-Therapy 131I Whole-Body Scans
Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - July 24, 2012 Category: Endocrinology Tags: article Source Type: research
One Month Is Sufficient for Urinary Iodine to Return to Its Baseline Value After the Use of Water-Soluble Iodinated Contrast Agents in Post-Thyroidectomy Patients Requiring Radioiodine Therapy
Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - July 24, 2012 Category: Endocrinology Tags: article Source Type: research
Comment on Rosenbaum-Krumme et al.: 18F-FDG PET/CT changes therapy management in high-risk DTC after first radioiodine therapy
Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00259-012-2191-zAuthors
Francesco Bertagna, Department of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, ItalyRaffaele Giubbini, Department of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy
Journal European Journal of Nuclear Medicine and Molecular ImagingOnline ISSN 1619-7089Print ISSN 1619-7070 (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 18, 2012 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: research
Pre-therapeutic blood dosimetry in patients with differentiated thyroid carcinoma using 124-iodine: predicted blood doses correlate with changes in blood cell counts after radioiodine therapy and depend on modes of TSH stimulation and number of preceding radioiodine therapies
Conclusions The range of BDpA among DTC patients is rather wide. Our results suggest that lower blood doses can be expected when using
exogenous TSH stimulation and blood doses are generally higher at first RAIT compared to subsequent RAITs. Thus, we advise
to make blood dosimetry standard praxis prior to a high-activity RAIT.
Content Type Journal ArticleCategory Original articlePages 1-7DOI 10.1007/s12149-012-0632-1Authors
Verena Hartung-Knemeyer, Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen, Hufelandstraße 55, 45147 Essen, GermanyJames Nagarajah, Department of Nuclea...
Source: Annals of Nuclear Medicine - July 17, 2012 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: research
Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy
er
& N L Eberhardt (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - July 13, 2012 Category: Cancer & Oncology Authors: H V ReddiP MaddeS J McDonoughM A TrujilloJ C MorrisR M MyersK W PengS J RussellB McIverN L Eberhardt Tags: anaplastic thyroid carcinoma MV-NIS sodium iodide symporter dysfunction novel therapeutic agent Source Type: research
Small differentiated thyroid cancer: Time to reconsider clinical management and treatment
Abstract: The incidence of differentiated thyroid cancer (DTC) is increasing worldwide, especially among small (≤2 cm) tumors. Overall, small DTC have an excellent prognosis and low mortality rate. Still, a proportion of these patients will experience recurrent/persistent disease. Careful risk stratification makes it possible to individualize treatment, avoiding unnecessary procedures and guarantees a good long-term prognosis with low recurrence risk. Recent studies evaluated the impact of the extent of surgery and radioiodine therapy, providing new evidence regarding treatment approach. Therefore, is time to reconsider...
Source: Surgical Oncology - July 9, 2012 Category: Surgery Authors: Denise Prado Momesso, Fernanda Vaisman, Cencita Hosanah Cordeiro de Noronha Pessoa, Rossana Corbo, Mario Vaisman Tags: General Papers Source Type: research
[Radiologic and nuclear medicine diagnosis and therapy of thyroid disorders : Part 1: Benign thyroid diseases].
[Radiologic and nuclear medicine diagnosis and therapy of thyroid disorders : Part 1: Benign thyroid diseases].
Radiologe. 2012 Jul;52(7):661-78
Authors: Zechmann CM, Haufe SE
Abstract
The thyroid gland is one of the most important endocrine organs. It has multiple influences on physical and mental health. The most important benign diseases are goiter, thyroid adenomas and inflammation. The clinical, imaging and laboratory findings are often pathognomic. The therapy spectrum ranges from follow-up, to medication or definitive therapy by operation or radioiodine therapy.
PMID: 22801791 [PubMed - in proces...
Source: Der Radiologe - July 1, 2012 Category: Radiology Authors: Zechmann CM, Haufe SE Tags: Radiologe Source Type: research
[SPECT/CT for staging and treatment monitoring in oncology : Applications in differentiated thyroid cancer and liver tumors].
[SPECT/CT for staging and treatment monitoring in oncology : Applications in differentiated thyroid cancer and liver tumors].
Radiologe. 2012 Jul;52(7):646-52
Authors: Weber K, Berger F, Mustafa M, Reiser MF, Bartenstein P, Haug A
Abstract
CLINICAL/METHODICAL ISSUE: Hybrid imaging of function and morphology has gained significant importance for lesion detection and treatment monitoring in oncology. In patients with differentiated thyroid carcinoma (DTC) a planar whole body scan is carried out after radioiodine therapy (RIT) for staging. However, due to limited spatial resolution the diagnostic a...
Source: Der Radiologe - July 1, 2012 Category: Radiology Authors: Weber K, Berger F, Mustafa M, Reiser MF, Bartenstein P, Haug A Tags: Radiologe Source Type: research
18F-FDG PET/CT changes therapy management in high-risk DTC after first radioiodine therapy
Conclusion
18F-FDG PET/CT resulted in a change of therapeutic procedure in 11 of 90 patients and in a change of patient management through
additional diagnostic measures in 8 of 90 patients, and is consequently very helpful in initial staging. At our hospital,
18F-FDG PET/CT in high-risk patients with differentiated thyroid carcinoma has been established as an initial staging modality.
Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00259-012-2065-4Authors
Sandra J. Rosenbaum-Krumme, Department of Nuclear Medicine, University Hospital Essen, Hufelandstraße 55, 45122 Ess...
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 21, 2012 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: research
In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease‐free interval
ConclusionIn PTC, BRAFV600E induces uPA and uPAR expression. The latter, but not BRAFV600E, associates with advanced stages and shorter DFI. If confirmed in larger case studies, they may represent reliable prognostic markers for more accurate risk stratification and post‐operative decision‐making in PTC patients.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - June 15, 2012 Category: Endocrinology Authors: Salvatore Ulisse, Enke Baldini, Salvatore Sorrenti, Susi Barollo, Natalie Prinzi, Antonio Catania, Angela Nesca, Lucio Gnessi, Maria Rosa Pelizzo, Caterina Mian, Corrado Vito, Anna Calvanese, Silvio Palermo, Severino Persechino, Enrico Antoni, Massimino D Tags: Original Article Source Type: research
NIS modulation by PI3K, Akt and mTORC1 inhibition
Decreased NaC/IK symporter (NIS) expression or function in thyroid cancers reduces the effectiveness of radioiodine (131I) in diagnosis and treatment. Liu and colleagues investigated the effect of inhibiting for PI3K, Akt, and mTORC1 on NIS modulation in thyroid cancer cells, finding PI3K inhibition by LY294002 increased NIS-mediated radioiodide uptake via NIS upregulation. They also observed that while Akt inhibition did not increase NIS protein levels, a marked increase in radioiodine uptake occurred via a decreased iodide efflux rate, increased iodide transport rate and increased NIS iodide affinity. These observations ...
Source: Society for Endocrinology - June 11, 2012 Category: Endocrinology Source Type: news
Retro-Orbital Metastasis from Differentiated Thyroid Carcinoma in a Radioiodine Therapy-Naïve Patient: Any Lesson Learned
Med Princ Pract (DOI:10.1159/000339114) (Source: Medical Principles and Practice : Last 20 articles)
Source: Medical Principles and Practice : Last 20 articles - June 5, 2012 Category: Internal Medicine Source Type: research
Retro-Orbital Metastasis from Differentiated Thyroid Carcinoma in a Radioiodine Therapy-Naïve Patient: Any Lesson Learned?
Med Princ Pract (DOI:10.1159/000339114) (Source: Medical Principles and Practice : Last 20 articles)
Source: Medical Principles and Practice : Last 20 articles - June 5, 2012 Category: Internal Medicine Source Type: research
Prestimulation with Recombinant Human Thyrotropin (rhTSH) Improves the Long-Term Outcome of Radioiodine Therapy for Multinodular Nontoxic Goiter.
Conclusion:Enhanced goiter volume reduction with rhTSH-augmented (131)I therapy improves the long-term reduction in goiter-related symptoms and reduces the need for additional therapy compared with plain (131)I therapy. Overall patient satisfaction is benefited, despite a higher rate of permanent hypothyroidism.
PMID: 22577172 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 10, 2012 Category: Endocrinology Authors: Fast S, Nielsen VE, Grupe P, Boel-Jørgensen H, Bastholt L, Andersen PB, Bonnema SJ, Hegedüs L Tags: J Clin Endocrinol Metab Source Type: research
SPECT/CT Helps Staging and Risk Stratification of Thyroid Cancer
SPECT/CT, commonly used for imaging thyroid cancer after radioiodine therapy, was used before therapy to better identify and characterize the cancer. (Source: Diagnostic Imaging)
Source: Diagnostic Imaging - May 8, 2012 Category: Radiology Source Type: news
Staging and risk stratification of thyroid cancer improved with SPECT/CT
(Society of Nuclear Medicine) The use of single positron emission computed tomography (SPECT)/computed tomography (CT) has been reported to change clinical management in a significant number of thyroid cancer patients according to research presented in the May issue of The Journal of Nuclear Medicine. Information obtained from these scans not only helps determine the need for radioiodine therapy or alternative options, but also impacts the long-term follow-up strategy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 3, 2012 Category: Cancer & Oncology Source Type: news
Pioglitazone therapy in progressive differentiated thyroid carcinoma.
Conclusion: Pioglitazone revealed some positive effects in radioiodine negative and progressive DTC patients but it did not fulfill the expectations given by the results of rosiglitazone therapy.
PMID: 22532159 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - April 25, 2012 Category: Radiology Authors: Rosenbaum-Krumme SJ, Bockisch A, Nagarajah J Tags: Nuklearmedizin Source Type: research
Reoperative Lymph Node Dissection for Recurrent Papillary Thyroid Cancer and Effect on Serum Thyroglobulin
Conclusions Reoperative treatment of recurrent or persistent PTC can be performed with low complication rates, and Tg levels greatly decrease
in most patients; however, few achieve undetectable stimulated Tg.
Content Type Journal ArticleCategory Endocrine TumorsPages 1-7DOI 10.1245/s10434-012-2380-9Authors
David T. Hughes, Department of Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USAAmanda M. Laird, Department of Surgery, University of Michigan, Ann Arbor, MI, USABarbra S. Miller, Department of Surgery, University of Michigan, Ann Arbor, MI, USAPaul G. Gauger, D...
Source: Annals of Surgical Oncology - April 24, 2012 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: research
Combining transfer of TTF-1 and Pax-8 gene: a potential strategy to promote radioiodine therapy of thyroid carcinoma
& A Kuang (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - April 13, 2012 Category: Cancer & Oncology Authors: D MuR HuangS LiX MaC LouA Kuang Tags: Pax-8 radioiodine therapy thyroid carcinoma TTF-1 Source Type: research
Radioiodine retention on percutaneous endoscopic gastrostomy tubes.
Abstract
An 80-year-old male with recurrent thyroid cancer and a percutaneous endoscopic gastrostomy (PEG) tube in situ was referred for radioiodine therapy and was administered 5510 MBq I-131 sodium iodide intravenously. Sequential whole-body images taken over the subsequent 7 days for dosimetric evaluation revealed an area of persistent high uptake in the abdomen. Delayed imaging with single photon emission CT/CT at 15 days post administration revealed this uptake to be at the junction of the PEG tube with the anatomically normal stomach wall. We hypothesise that the PEG tube became contaminated by radioiodine se...
Source: The British Journal of Radiology - April 1, 2012 Category: Radiology Authors: Scuffham JW, Wood KA, Clauss RP, Kilfeather SA, Hinton PJ Tags: Br J Radiol Source Type: research
131I gastric uptake with and without omeprazole in patients undergoing radioiodine therapy for differentiated thyroid carcinoma
Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00259-012-2104-1Authors
Gabriel Castro, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chile, ChileIsabel Berrocal, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chile, ChileJaime Carmona, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago de Chile, ChileJaviera González, Nuclear Medicine Section, University of Chile Clinical Hospital, Santos Dumont 999, Ind...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 30, 2012 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: research
Thyroid remnant ablation using 1,110 MBq of I-131 after total thyroidectomy: regulatory considerations on release of patients after unsealed radioiodine therapy
Conclusion Outpatient-based remnant thyroid ablation with I-131 (1,110 MBq) performed after total thyroidectomy in patients with differentiated
thyroid cancer is safe if applied in accordance with the appropriate supervision and guidance by experts with certain qualifications.
Content Type Journal ArticleCategory Technical notePages 1-9DOI 10.1007/s12149-012-0590-7Authors
Kiyoko Kusakabe, Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University, Tokyo, JapanKunihiko Yokoyama, Department of Thyroidology, Public Central Hospital of Matto Ishikawa, Hakusan, JapanKoi...
Source: Annals of Nuclear Medicine - March 26, 2012 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: research
