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Targeted therapies in thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Differentiated thyroid carcinoma is the most frequent neoplasm of the endocrine system. Although thyroid cancer usually has an excellent prognosis, no therapeutic options are available for patients that develop metastases and are or became resistant to radioiodine therapy. The deeper knowledge of molecular aberrations that characterize tumor growth has provided novel targets in cancer therapy. Several proteins have been implicated as having a crucial role in the carcinogenesis of differentiated thyroid cancer, such as those involved in RET/PTC-RAS-RAF-MAPK pathway. Moreover, vascular aberrations and...
Source: Targeted Oncology - November 10, 2009 Category: Cancer & Oncology Tags: Targeted Oncology Source Type: journals

Radioiodine, Smoking Linked to Eye Disease in Graves' HyperthyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Radioiodine therapy and smoking increase the risk of developing thyroid-associated ophthalmopathy in patients with Graves' hyperthyroidism, say researchers from Sweden in the October issue of The Journal of Clinical Endocrinology & Metabolism. Reuters Health Information (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - November 9, 2009 Category: Drugs & Pharmacology Tags: Diabetes & Endocrinology Source Type: info

Outcome After High-Dose Radioiodine Therapy for Advanced Differentiated Thyroid Carcinoma in ChildhoodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Endocrine Research)
Source: Endocrine Research - November 1, 2009 Category: Endocrinology Authors: Gao, Yun-ChaoLu, Han-Kui Source Type: journals

Takotsubo cardiomyopathy following radioiodine therapy for toxic multinodular goitre.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a 73-year-old man with a toxic multinodular goitre, which was treated with radioiodine therapy (I-131) without pretreatment with an antithyroid drug. Four weeks later he presented with rapidly progressive dyspnoea and a significant increase in free thyroxin. The electrocardiogram showed ST -segment elevation, and echocardiography demonstrated apical akinesia and a left ventricular ejection fraction of only 25%. However, direct coronary catheterisation showed no evidence of coronary artery disease. Left ventricular angiography showed apical ballooning consistent with the diagnosis of takotsubo cardiomyopathy. F...
Source: The Netherlands Journal of Medicine - November 1, 2009 Category: Journals (General) Authors: van de Donk NW, America YG, Zelissen PM, Hamer BJ Tags: Neth J Med Source Type: journals

A case of thyroid storm following radioiodine therapy underlying usefulness of cardiac MRI.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19782905 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - September 30, 2009 Category: Internal Medicine Authors: Thebault C, Leurent G, Potier J, Bedossa M, Bonnet F Tags: Eur J Intern Med Source Type: journals

Targeted Radioiodine Therapy of Neuroblastoma Tumors following Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In conclusion, our data clearly show the high potential of novel pseudodendritic polymers for tumor-specific NIS gene delivery after systemic application, opening the prospect of targeted NIS-mediated radionuclide therapy of nonthyroidal tumors even in metastatic disease. (Clin Cancer Res 2009;15(19):6079-86). PMID: 19789324 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 28, 2009 Category: Cancer & Oncology Authors: Klutz K, Russ V, Willhauck MJ, Wunderlich N, Zach C, Gildehaus FJ, Göke B, Wagner E, Ogris M, Spitzweg C Tags: Clin Cancer Res Source Type: journals

[Subjective perception of radioactivity - no change post successful treatment with radioiodine]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Patients continue to view radioactivity as something negative despite treatment success following radioiodine therapy. Our results provide useful information for patient information by the nuclear medicine physician prior to a radioiodine therapy. PMID: 19322502 [PubMed - indexed for MEDLINE] (Source: Nuklearmedizin)
Source: Nuklearmedizin - September 19, 2009 Category: Radiology Authors: Freudenberg L, Müller S, Beyer T, Bockisch A Tags: Nuklearmedizin Source Type: journals

A dose-effect correlation for radioiodine ablation in differentiated thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A successful ablation is strongly dependent on the absorbed dose to the thyroid remnant. Dosimetry-based personalized treatment can prevent both sub-optimal administrations, which entails further radioiodine therapy, and excessive administration of radioactivity, which increases the potential for radiation toxicity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1261-3Authors Glenn D. Flux, Royal Marsden NHS Foundation Trust Department of Physics Downs Road Sutton Surrey SM2 5PT UKMasud Haq, Royal Marsden NHS Foundation Trust Thyroid Unit Downs Road Sutton Surr...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 17, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Goitre and thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Thyroid enlargement is common and thyroid malignancy rare, but the clinical presentation of benign and malignant disease are similar. The aim of clinical assessment and investigations is to identify the small number of cancers amongst the non-malignant thyroid enlargements. Investigations include thyroid function tests and fine-needle aspiration cytology. Benign thyroid disease needs treatment only in the presence of dysfunction or local compressive symptoms. The treatment of thyroid cancer is multidisciplinary and includes surgery, radioiodine therapy and lifelong thyroid-stimulating hormone suppression. The dia...
Source: Medicine - July 31, 2009 Category: Internal Medicine Authors: Fausto Palazzo Tags: Thyroid Source Type: journals

Construction of a MUC-1 promoter driven, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for gene therapy of breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This construct may allow multimodal therapy, combining virotherapy with radioiodine therapy to be developed as a novel treatment for breast and other MUC1 overexpressing cancers. (Source: Breast Cancer Research)
Source: Breast Cancer Research - July 26, 2009 Category: Cancer & Oncology Authors: Miguel TrujilloMichael OnealJulia DavydovaElizabeth BergertMasato YamamotoJohn Morris Source Type: journals

Radiofrequency Ablation for the Treatment of Autonomously Functioning Thyroid NodulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions RFA seems to be effective and safe for the treatment of AFTN. Content Type Journal ArticleDOI 10.1007/s00268-009-0130-3Authors Jung Hwan Baek, Thyroid Center, Daerim St. Mary’s Hospital Department of Radiology #978-13 Daerim-dong, Youngdeunpo-gu Seoul 150-070 KoreaWon-Jin Moon, Konkuk University Hospital, Konkuk University School of Medicine Department of Radiology 4-12 Hwayang-dong, Gwangjin-ku Seoul 143-729 KoreaYoon Suk Kim, Thyroid Center, Daerim St. Mary’s Hospital Department of Radiology #978-13 Daerim-dong, Youngdeunpo-gu Seoul 150-070 KoreaJeong Hyun Lee, University of Ulsan Coll...
Source: World Journal of Surgery - July 6, 2009 Category: Surgery Tags: World Journal of Surgery Source Type: journals

Radioiodine therapy of differentiated thyroid cancer: radiologic impact of out-patient treatment with 100 to 150 mCi Iodine-131 activitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: No radiological impact was detected after iodine therapy with 100-150 mCi on an out-patient basis followed by experienced professionals. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - July 5, 2009 Category: Endocrinology Source Type: journals

Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The sodium iodide symporter (NIS) mediates iodide uptake into the thyroid. Because of this mechanism, differentiated thyroid cancer is susceptible for radioiodine therapy. Functional NIS expression in extrathyroidal tumors has been reported mainly in breast cancer. We screened colorectal tumors for NIS expression and investigated the mechanisms regulating NIS activity. Cell lines were screened for iodide uptake in vitro and NIS expression was evaluated by real-time RT-PCR, immunocytochemistry and immunoblotting. Iodide and pertechnetate uptake were evaluated in allograft tumors by biodistribution studies and scintigraphy. ...
Source: International Journal of Cancer - June 29, 2009 Category: Cancer & Oncology Authors: Florian C. Gaertner, Franziska Rohde, Jan Mueller, Birgit Blechert, Klaus-Peter Janssen, Markus Essler Source Type: journals

Changing trends in the treatment of Graves' disease with radioiodine: a 12-year experience in a university hospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Radioiodine therapy has increasingly been accepted for treatment of patients with Graves' disease and the doses delivered have increased to achieve a permanent cure as well as a reduction of the chances of recurrence. (Source: Radiologia Brasileira)
Source: Radiologia Brasileira - June 25, 2009 Category: Radiology Source Type: journals

Subjective perceptions of patients undergoing radioiodine therapy: why should we know about them?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00259-009-1188-8Authors Lutz S. Freudenberg, Universitätsklinikum Essen Klinik für Nuklearmedizin Hufelandstraße 55 45122 Essen GermanyStefan P. Müller, Universitätsklinikum Essen Klinik für Nuklearmedizin Hufelandstraße 55 45122 Essen GermanyAndreas Bockisch, Universitätsklinikum Essen Klinik für Nuklearmedizin Hufelandstraße 55 45122 Essen Germany Journal European Journal of Nuclear Medicine and Molecular ImagingOnline ISSN 1619-7089Print ISSN 1619-7070 (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 13, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Subjective perceptions of patients undergoing radioiodine therapy: why should we know about them?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19526231 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - June 12, 2009 Category: Radiology Authors: Freudenberg LS, Müller SP, Bockisch A Tags: Eur J Nucl Med Mol Imaging Source Type: journals

What is the optimal initial treatment of low-risk papillary thyroid cancer (and why is it controversial)?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of papillary thyroid cancer has been rising steadily over the past 3 decades. Most tumors in this setting are regarded as low risk, but recurrence rates are high, producing controversy about initial therapy. Microcarcinomas smaller than 1 cm are generally best treated with lobectomy alone. Total thyroidectomy should be performed for tumors 1 cm or larger or for tumors that have metastasized. Prophylactic central and lateral neck lymph node compartment dissection uncovers unsuspected metastases in about half the patients, which may alleviate the need for postsurgical radioiodine therapy but can be associat...
Source: Oncology (Williston Park, N.Y.) - May 31, 2009 Category: Cancer & Oncology Authors: Mazzaferri EL Tags: Oncology (Williston Park) Source Type: journals

Synchronous papillary carcinoma in thyroglossal duct cyst and thyroid gland: Case report and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of synchronous occurrence of thyroglossal duct cyst carcinoma and thyroid carcinoma and discuss its management in detail.A 59-year-old woman was clinically diagnosed to have a thyroglossal duct cyst and a solitary nodule. Fine-needle aspiration cytology revealed a papillary carcinoma in the thyroglossal duct cyst and a colloid in the thyroid nodule. Sistrunk's procedure along with a total thyroidectomy was performed followed by postoperative radioiodine ablation.Histopathologic examination revealed thyroglossal duct cyst carcinoma and bilateral foci of papillary carcinoma in the thyroid gland. She has...
Source: Head - April 1, 2009 Category: ENT & OMF Authors: Mathew Pynumootil Cherian, Balakrishnan Nair, Shaji Thomas, Thara Somanathan, Paul Sebastian Source Type: journals

The relationship between 24 h/4 h radioiodine-131 uptake ratio and outcome after radioiodine therapy in 1402 patients with solitary autonomously functioning thyroid nodulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The 131I UR can predict the outcome of 131I treatment in AFTN and may have utility in modifying treatment in some patients to limit post-radioiodine induced hypothyroidism and treatment failures in order to achieve euthyroidism. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-009-0232-xAuthors Mauro Filesi, ‘La Sapienza’ University Department of Clinical Sciences, Nuclear Medicine, Policlinico Umberto I Viale del Policlinico 155 00161 Rome ItalyLaura Travascio, ‘La Sapienza’ University Department of Clinical Sciences, Nuclear Medicine, Policlinico Umberto I V...
Source: Annals of Nuclear Medicine - March 26, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

[HEAD & NECK] The Role of MR Imaging in Detecting Nodal Disease in Thyroidectomy Patients with Rising Thyroglobulin LevelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: MR imaging of the neck should be considered in thyroidectomy patients with rising serum thyroglobulin levels and a history of radioiodine therapy and neck dissection. Radiologists should carefully examine the retropharyngeal and parapharyngeal spaces in these patients because nodal metastases may occur there more commonly than realized. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 11, 2009 Category: Radiology Authors: Kaplan, S.L., Mandel, S.J., Muller, R., Baloch, Z.W., Thaler, E.R., Loevner, L.A. Tags: HEAD & NECK Source Type: journals

A novel view on dosimetry-related radionuclide therapy: Presentation of a calculatory model and its implementation for radioiodine therapy of metastasized differentiated thyroid carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Redistribution of therapeutic activities along the model, i.e. taking into account success and risk, may enhance response while on average saving activity as exemplarily shown by a virtual comparison with standard approaches using literature data from DTC for implementation. The model may thus provide a guideline for the prescription of therapeutic activities; the results underline the potential impact of individual dosimetry in radionuclide therapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1077-1Authors Alexander R. Stahl, University of Duisburg-Essen Cl...
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 27, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Radioiodine Therapy for Thyroid Cancer Depicted Uterine Leiomyoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 180DOI: 10.1097/RLU.0b013e3181966ff0Authors: Hirata, Kenji MD *; Shiga, Tohru MD, PhD *; Kubota, Kanako C. MD +; Okamoto, Shozo MD *; Kamibayashi, Tomohito MD *; Tamaki, Nagara MD, PhD * (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - February 20, 2009 Category: Radiology Tags: Abstract HTML PDF (322 K) Source Type: journals

Nuclear Medicine: Proof of Principle for Targeted Drugs in Diagnosis and Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is going to show that molecular imaging probes in Nuclear Medicine can be regarded as proof of principle of many of recent trends in diagnosis and therapy and offers exciting opportunities for further developments. Radioiodine therapy of benign and malignant thyroid disease has been established in Nuclear Medicine over six decades ago and is a fine example for using the same highly specific probe for diagnosis and treatment of a given disease. The use of radio labeled monoclonal antibodies against surface receptors of tumor cells (e.g. CEA) dominated diagnostic Nuclear Medicine in the eighties and sees a recen...
Source: Current Pharmaceutical Design - January 21, 2009 Category: Drugs & Pharmacology Authors: Leitha T Tags: Curr Pharm Des Source Type: journals

Induction of iodide uptake in transformed thyrocytes: a compound screening in cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We hypothesize that testing of cells from primary tumours or metastases in patients may be a way to identify compounds with optimum therapeutic efficacy for individualized treatment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-008-1024-6Authors Eleonore Fröhlich, University of Tuebingen Department of Endocrinology, Metabolism, Nephrology and Clinical Chemistry, Internal Medicine Otfried-Muellerstrasse 10 72076 Tuebingen GermanyPeter Brossart, University of Tuebingen Department of Haematology, Oncology, Immunology and Rheumatology, Internal Medicine Otfried-Muelle...
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 24, 2008 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Radioiodine Therapy (RAI) for Graves' Disease (GD) and the Effect on Ophthalmopathy: A Systematic ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Does radioiodine therapy for Graves' disease, antithyroid drugs, or surgery raise the risk of ophthalmopathy? Does glucocorticoid prophylaxis effectively prevent ophthalmopathy occurrence/progression? Clinical Endocrinology (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - December 23, 2008 Category: Radiology Tags: Diabetes & Endocrinology Source Type: info

Different strategies to overcome the effect of carbimazole on high- and low-dose radioiodine therapy: results from continuous dose-effect models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Simultaneous carbimazole reduces the euthyroidism rate, the aim of low-dose radioiodine therapy, over the entire target dose range in both Graves' disease and toxic nodular goitre. Therefore, antithyroid drug discontinuation should be preferred in low-dose radioiodine therapy. Conversely, escalation of the target dose should be preferred in high-dose radioiodine therapy. PMID: 19087129 [PubMed - in process] (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 20, 2008 Category: Journals (General) Authors: Walter MA, Schindler C, Christ-Crain M, Müller-Brand J, Müller B Tags: Eur J Clin Invest Source Type: journals

Stunning in radioiodine therapy of benign thyroid disease. Quantification and therapeutic relevance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Relative uptake of subsequent radioiodine fractions decreases with time after first administration and with increasing delivered dose to the thyroid. If a second fraction of (131)I is given at an earlier time, the same therapeutic effect can be reached using lower amounts of activity, minimising radiation exposure and increasing efficiency of radioiodine therapy. PMID: 19057798 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - December 7, 2008 Category: Radiology Authors: Krohn T, Meyer PT, Ocklenburg C, Knollmann D, Nowak B, Schaefer WM Tags: Nuklearmedizin Source Type: journals

[Salivary gland damage after (131)I therapy in patient with differentiated thyroid cancer. Preliminary report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The main conclusion is that a single dose of (131)I has no significant influence on salivary gland function; a repeated high-doses therapy is connected with an essential risk of side-effect occurrence. Scintigraphy can evaluate salivary gland function with high sensitivity. Parotid glands are more radiosensitive than submandibular. (Pol J Endocrinol 2008; 59 (5): 403-410). PMID: 18979451 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - December 1, 2008 Category: Endocrinology Authors: Macioszek A, Bączyk M, Kopeć T, Sowiński J Tags: Endokrynol Pol Source Type: journals

Diagnostic Whole-Body Scanning Before Radioiodine Therapy for Pulmonary Metastases of Differentiated Thyroid Cancer: Predictive Value and Recommendations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 845DOI: 10.1097/RLU.0b013e31818bf146Authors: Tachi, Yasushi MD *; Iwano, Shingo MD *; Kato, Katsuhiko MD *; Tadokoro, Masanori MD +; Naganawa, Shinji MD * (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 21, 2008 Category: Radiology Tags: Abstract HTML PDF (879 K) Source Type: journals

[Nuclear Medicine and Molecular Imaging] Incremental Value of Diagnostic 131I SPECT/CT Fusion Imaging in the Evaluation of Differentiated Thyroid CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. Iodine-131 SPECT/CT is useful for accurate evaluation of regional and distant activity in characterization of foci as residual thyroid tissue or nodal, pulmonary, or osseous metastasis. Suspected physiologic mimics of disease can be confirmed with increased reader confidence. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - November 19, 2008 Category: Radiology Authors: Wong, K. K., Zarzhevsky, N., Cahill, J. M., Frey, K. A., Avram, A. M. Tags: Nuclear Medicine and Molecular Imaging Source Type: journals

Thyroid cancer in infants and adolescents after Chernobyl.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Studies in children medically exposed to external irradiation more than 50 years ago revealed a considerably increased risk for thyroid cancer. Similarly, a strongly age-dependent risk for thyroid cancer was observed in the Japanese population after the atomic bomb explosions with the highest risk in the group of children below age of 10. After the Chernobyl accident, children from Belarus living in highly exposed regions received mean thyroid doses by radioactive fallout higher by a factor of approximately 2 as compared to the survivors of the atomic bomb explosions. This lead to a radiation related increase of thyroi...
Source: Nuklearmedizin - October 18, 2008 Category: Radiology Authors: Reiners C, Demidchik YE, Drozd VM, Biko J Tags: Minerva Endocrinol Source Type: journals

Relation between Graves' orbitopathy and radioiodine therapy for hyperthyroidism: facts and unsolved questions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18785990 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - September 10, 2008 Category: Endocrinology Authors: Tanda ML, Lai A, Bartalena L Tags: Clin Endocrinol (Oxf) Source Type: journals

Guidelines for radioiodine therapy of differentiated thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion For this purpose, recommendations have been formulated based on recent literature and expert opinion regarding the rationale, indications and contraindications for these procedures, as well as the radioiodine activities and the administration and patient preparation techniques to be used. Recommendations also are provided on pre-RAIT history and examinations, patient counselling and precautions that should be associated with 131I iodine ablation and treatment. Furthermore, potential side effects of radioiodine therapy and alternate or additional treatments to this modality are reviewed. Appendices...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 1, 2008 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Recombinant human thyrotropin stimulated radioiodine therapy of large nodular goiters facilitates tracheal decompression and improves inspiration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: On average, neither compression of the trachea nor deterioration of the pulmonary function was observed in the acute phase following rhTSH-augmented (131)I therapy. In the long term tracheal compression is diminished, and the inspiratory capacity improved, compared with (131)I therapy alone. PMID: 18664541 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 29, 2008 Category: Endocrinology Authors: Bonnema SJ, Nielsen VE, Boel-Jørgensen H, Grupe P, Andersen PB, Bastholt L, Hegedüs L Tags: J Clin Endocrinol Metab Source Type: journals

Conventional withdrawal of thyroid hormone before radioiodine therapy in differentiated thyroid carcinoma: how frequently are adequately raised TSH levels attained?Email this article to a colleague. Save this article to My Clippings. discuss this article 1 CommentDiscuss or comment on this article.
Clinical Endocrinology, Volume 69, Issue 1, Page 169-170, July 2008. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - June 18, 2008 Category: Endocrinology Tags: article Source Type: journals

Multiple Relapses of Hyperthyroidism after Thyroid Surgeries in a Patient with Long Term Follow-up of Sporadic Non-autoimmune HyperthyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a 22 year old male patient who was treated for his multiple relapses of hyperthyroidism by repeated subtotal thyroidectomies (STE). During the 22 years of follow-up, the patient developed several relapses of hyperthyroidism, four of them after thyroid surgeries. Sequencing of the TSHR gene revealed a gain-of-function mutation with an amino acid exchange of aspartate to tyrosine in codon 633 which is located in the sixth transmembrane domain of the TSH receptor. The absence of the mutation in all other family members identifies the patient's TSHR mutation as a sporadic germline mutation. In this patient, thyroi...
Source: Experimental and Clinical Endocrinology and Diabetes - June 6, 2008 Category: Endocrinology Tags: Article Source Type: journals

Survey of management of solitary thyroid nodules in Germany.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The main differences of opinion between practitioners and specialists focused on calcitonin screening and referral to radioiodine therapy. PMID: 18493687 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - May 22, 2008 Category: Radiology Authors: Dietlein M, Wegscheider K, Vaupel R, Schmidt M, Schicha H Tags: Nuklearmedizin Source Type: journals

An outline concerning the potential use of recombinant human thyrotropin for improving radioiodine therapy of multinodular goiterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Radioiodine (131I) treatment for nontoxic and toxic multinodular goiter (MNG) is an alternative therapeutic procedure used especially for patients with contraindication for surgery. Several studies have been conducted in recent years assessing the use of recombinant human TSH (rhTSH) in increasing 131I uptake in MNGs. This procedure also decreases the activity level of the administered 131I, changes the distribution of 131I in the thyroid, lowers the absorption dose, and dramatically reduces the volume of the goiter (50–75% of the baseline volume). A major disadvantage, however, is the induction of...
Source: Endocrine - May 20, 2008 Category: Endocrinology Tags: Endocrine Source Type: journals

Graves' Disease and Thyroid Associated Ophthalmopathy following Radioiodine Therapy in Euthyroid Multinodular GoiterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thyroid May 2008, Vol. 18, No. 5: 585-585. (Source: Thyroid)
Source: Thyroid - May 8, 2008 Category: Endocrinology Tags: article Source Type: journals

[Is radioiodine therapy conducted too late in patients suffering from thyroid autonomy?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Despite clear recommendations in corresponding guidelines too much time passes between first symptoms (median: 73 months), primary diagnosis of therapy relevant thyroid autonomy (median: 2 months) and implementation of RIT. Patients with functional and/or local symptoms should be examined for thyroid autonomy early. If thyroid autonomy is proven, RIT should be planned immediately, especially in high-risk patients. PMID: 18278206 [PubMed - indexed for MEDLINE] (Source: Nuklearmedizin)
Source: Nuklearmedizin - May 7, 2008 Category: Radiology Authors: Spilker L, Happel C, Döbert N, Grünwald F Tags: Nuklearmedizin Source Type: journals

[Radioiodine therapy in thyroid autonomy: initial results and experiences.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of radioiodine therapy in the analysed patient group are coherent with the data of several large studies. According to the references, the success rate of 85-100% are satisfying and the incidence of hypothyroidism of 10-20% is acceptable. PMID: 18436512 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - April 26, 2008 Category: Journals (General) Authors: Bajner A Tags: Orv Hetil Source Type: journals

Does radioiodine therapy for hyperthyroidism increase long-term morbidity?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18317480 [PubMed - as supplied by publisher] (Source: Nature Clinical Practice Endocrinology and Metabolism)
Source: Nature Clinical Practice Endocrinology and Metabolism - March 4, 2008 Category: Endocrinology Authors: Burman KD Tags: Nat Clin Pract Endocrinol Metab Source Type: journals

[Acute effects of radioiodine therapy on the voice and larynx of Basedow-Graves patients.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Radioiodine therapy does not affect voice quality. PMID: 18568200 [PubMed - in process] (Source: Revista Brasileira de Otorrinolaringologia)
Source: Revista Brasileira de Otorrinolaringologia - March 1, 2008 Category: ENT & OMF Authors: Isolan-Cury RW, Monte O, Cury AN, Andrada E Silva MA, Duprat A, Marone M, Almeida R, Iglesias A Tags: Rev Bras Otorrinolaringol (Engl Ed) Source Type: journals

[Acute effects of radioiodine therapy on the voice and larynx of Basedow-Graves patients]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Radioiodine therapy does not affect voice quality. PMID: 18568200 [PubMed - in process] (Source: Revista Brasileira de Otorrinolaringologia)
Source: Revista Brasileira de Otorrinolaringologia - March 1, 2008 Category: ENT & OMF Authors: Isolan-Cury RW, Monte O, Cury AN, Andrada E Silva MA, Duprat A, Marone M, Almeida R, Iglesias A Tags: Rev Bras Otorrinolaringol (Engl Ed) Source Type: journals

[Influence of the endogene TSH stimulation of thyroid volume increase in the patients after total thyroidectomy due to differentiated thyroid cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: L-Thyroxine withdrawal in the patients after total thyroidectomy due to DTC can cause re-growth of the tissue remnants. The phenomenon may be of a clinical significance in the selected cases influencing therapeutic decisions. PMID: 18465686 [PubMed - indexed for MEDLINE] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2008 Category: Endocrinology Authors: Pietz L, Michałek K, Waśko R, Ruchała M, Sowiński J Tags: Endokrynol Pol Source Type: journals

Graves' disease and radioiodine therapy. Is success of ablation dependent on the achieved dose above 200 Gy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: To achieve a dose of over 200 Gy with the above standard deviation, we recommend calculating an intended dose of 250 Gy and using a dosimetric approach with early and late uptake values in the radioiodine test, to allow early therapeutic intervention should the posttherapeutic thyroid dose fall unexpectedly below 200 Gy. PMID: 18278207 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - February 19, 2008 Category: Radiology Authors: Kobe C, Eschner W, Sudbrock F, Weber I, Marx K, Dietlein M, Schicha H Tags: Nuklearmedizin Source Type: journals

Is radioiodine therapy conducted too late in patients suffering from thyroid autonomy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Despite clear recommendations in corresponding guidelines too much time passes between first symptoms (median: 73 months), primary diagnosis of therapy relevant thyroid autonomy (median: 2 months) and implementation of RIT. Patients with functional and/or local symptoms should be examined for thyroid autonomy early. If thyroid autonomy is proven, RIT should be planned immediately, especially in high-risk patients. PMID: 18278206 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - February 19, 2008 Category: Radiology Authors: Spilker L, Happel C, Döbert N, Grünwald F Tags: Nuklearmedizin Source Type: journals

The carcinogenic effects of radioiodine therapy for thyroid carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18283326 [PubMed - as supplied by publisher] (Source: Nature Clinical Practice Endocrinology and Metabolism)
Source: Nature Clinical Practice Endocrinology and Metabolism - February 19, 2008 Category: Endocrinology Authors: de Vathaire F Tags: Nat Clin Pract Endocrinol Metab Source Type: journals

Decreased radioiodine uptake of FRTL-5 cells after 131I incubation in vitro: molecular biological investigations indicate a cell cycle-dependent pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions It could be demonstrated that during 131I incubation of FRTL-5 cells, radioiodine uptake decreased significantly. Simultaneously decreasing levels of NIS mRNA and protein expression suggest a NIS-associated mechanism. Since mRNA levels of housekeeping genes decreased, too, the reduced NIS expression might be provoked by a cell cycle arrest. Our investigations recommend the FRTL-5 model as a valuable tool for further molecular biological investigations of the stunning phenomenon. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-007-0666-0Authors Birgit Meller, Univer...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 29, 2008 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Visualization of nasolacrimal drainage system after radioiodine therapy in patients with thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to report three cases with an accumulation of 131I in the nasolacrimal duct after radioiodine therapy for papillary thyroid cancer. A whole-body scan was taken 3 days after the administration of 3.7 GBq of 131I. Single-photon emission computed tomography (SPECT)/CT images were added when the location of a focal tracer uptake was undetermined on whole-body scans. In case 1, a 62-year-old woman complained of epiphora of the left eye after nine radioiodine therapies with a cumulative dose of 31.08 GBq. The left nasolacrimal duct was visualized at her tenth treatment with 131I. In case 2,...
Source: Annals of Nuclear Medicine - November 21, 2007 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals