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Animal models of sleep disorders.
Abstract Problems with sleep affect a large part of the general population, with more than half of all people in the United States reporting difficulties with sleep or insufficient sleep at various times and about 40 million affected chronically. Sleep is a complex physiologic process that is influenced by many internal and environmental factors, and problems with sleep are often related to specific personal circumstances or are based on subjective reports from the affected person. Although human subjects are used widely in the study of sleep and sleep disorders, the study of animals has been invaluable in developi...
Source: Comparative Medicine - May 23, 2013 Category: Zoology Authors: Toth LA, Bhargava P Tags: Comp Med Source Type: research

The Prevalence of Restless Legs Syndrome across the Full Spectrum of Kidney Disease
Conclusions:RLS is common in non-dialysis-dependent CKD patients and is an important source of sleep disruption.Citation:Lee J; Nicholl DDM; Ahmed SB; Loewen AHS; Hemmelgarn BR; Beecroft JM; Turin TC; Hanly PJ. The prevalence of restless legs syndrome across the full spectrum of kidney disease. J Clin Sleep Med 2013;9(5):455-459. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 17, 2013 Category: Sleep Medicine Source Type: research

Exacerbation of restless legs syndrome presenting as a psychiatric emergency
(Source: European Journal of Neurology)
Source: European Journal of Neurology - May 12, 2013 Category: Neurology Authors: M. Maestri, L. Carnicelli, E. Di Coscio, E. Iacopini, E. Bonanni Tags: Letter to the Editor Source Type: research

Making Sense Of The Neurobiology Of Restless Legs Syndrome And Related Insomnia
Johns Hopkins researchers believe they may have discovered an explanation for the sleepless nights associated with restless legs syndrome (RLS), a symptom that persists even when the disruptive, overwhelming nocturnal urge to move the legs is treated successfully with medication. Neurologists have long believed RLS is related to a dysfunction in the way the brain uses the neurotransmitter dopamine, a chemical used by brain cells to communicate and produce smooth, purposeful muscle activity and movement... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 9, 2013 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Prospective Study of Restless Legs Syndrome and Risk of Erectile Dysfunction
In conclusion, men with RLS had a higher risk of ED, and the magnitude of the risk increased with a higher frequency of RLS symptoms. Combinations of other sleep disorders with RLS further increased the risk of ED. (Source: American Journal of Epidemiology)
Source: American Journal of Epidemiology - May 9, 2013 Category: Epidemiology Authors: Li, Y., Batool-Anwar, S., Kim, S., Rimm, E. B., Ascherio, A., Gao, X. Tags: RESEARCH-ARTICLE Source Type: research

Restless Legs Syndrome, Insomnia and Brain Chemistry: A Tangled Mystery Solved? - 5/7/13
Johns Hopkins researchers believe they may have discovered an explanation for the sleepless nights associated with restless legs syndrome (RLS), a symptom that persists even when the disruptive, overwhelming nocturnal urge to move the legs is treated successfully with medication. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - May 7, 2013 Category: Research Source Type: news

Restless legs syndrome, insomnia and brain chemistry: A tangled mystery solved?
(Johns Hopkins Medicine) Johns Hopkins researchers believe they may have discovered an explanation for the sleepless nights associated with restless legs syndrome, a symptom that persists even when the disruptive, overwhelming nocturnal urge to move the legs is treated successfully with medication. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 7, 2013 Category: Global & Universal Source Type: news

Mirtazapine Provokes Periodic Leg Movements during Sleep in Young Healthy Men
Conclusions:Mirtazapine provoked PLMS in 67% of young healthy males. The effect was most pronounced in the first days. The possible role of serotonergic, noradrenergic and histaminergic mechanisms in mirtazapine-induced PLMS is discussed.Citation:Fulda S; Kloiber S; Dose T; Lucae S. Mirtazapine provokes periodic leg movements during sleep in young healthy men. SLEEP 2013;36(5):661-669. (Source: Sleep)
Source: Sleep - May 4, 2013 Category: Sleep Medicine Source Type: research

Differentiating Nonrestorative Sleep from Nocturnal Insomnia Symptoms: Demographic, Clinical, Inflammatory, and Functional Correlates
Conclusions:These findings suggest that there are substantial differences between NIS and NRS in terms of sociodemographic factors, comorbidity with other sleep and physical disorders, increased CRP level, and functional impairment. An inflammatory response might play a unique role in the pathogenesis of NRS.Citation:Zhang J; Lamers F; Hickie IB; He JP; Feig E; Merikangas KR. Differentiating nonrestorative sleep from nocturnal insomnia symptoms: demographic, clinical, inflammatory, and functional correlates. SLEEP 2013;36(5):671-679. (Source: Sleep)
Source: Sleep - May 4, 2013 Category: Sleep Medicine Source Type: research

[Original Articles] The Relationship Between Depressive Symptoms and Restless Legs Syndrome in Two Prospective Cohort Studies
Conclusions The presence of CRDS may be a risk factor for subsequent RLS. The relationship between the two disorders might be bidirectional because RLS also predicts incident depressive symptoms. (Source: Psychosomatic Medicine)
Source: Psychosomatic Medicine - May 3, 2013 Category: Psychiatry & Psychology Authors: Szentkiralyi, A., Volzke, H., Hoffmann, W., Baune, B. T., Berger, K. Tags: Neurology, Depression Original Articles Source Type: research

New Sleep Articles Available from April
Explore the latest in new sleep articles available from April. Learn how simple breathing exercises may help you to ease anxiety and improve your insomnia. Discover some of the serious consequences associated with sleep problems in pregnancy, including preeclampsia and gestational diabetes. What is ZzzQuil? Learn about this over-the-counter sleeping medication and how long it should be used to treat acute insomnia. Read about the Neupro patch, a medication that is delivered through the skin to treat restless legs syndrome (RLS) and Parkinson's disease. Finally, add to your understanding of nasal sprays that can be used to ...
Source: About Sleep Disorders - April 30, 2013 Category: Sleep Medicine Source Type: news

Restless legs syndrome is underdiagnosed in the US Renal Data System
(Source: QJM)
Source: QJM - April 21, 2013 Category: Internal Medicine Authors: Kutner, N. G., Zhang, R., Bliwise, D. L. Tags: Correspondence Source Type: research

Restless Legs Syndrome as the Presenting Symptom of Multiple Myeloma
We report a patient affected by restless legs syndrome as the presenting symptom of multiple myeloma, a hematologic malignancy characterized by clonal proliferation of plasma cells in the bone marrow and monoclonal immunoglobulin in the blood and/or urine.Citation:Aricò D; Raggi A; Siragusa M; Zucconi M; Ferri R. Restless legs syndrome as the presenting symptom of multiple myeloma. J Clin Sleep Med 2013;9(4):383-385. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 16, 2013 Category: Sleep Medicine Source Type: research

Latest Sleep Articles Available from March
Explore the latest sleep articles published in March. You can learn ways to decrease your anxiety and relieve insomnia. Consider how to treat restless legs syndrome (RLS) with iron supplements. Finally discover why you feel so sleepy after lunch (hint: it's not the food). Review a detailed article describing how you can sleep better at night. Expand your understanding of anatomy by learning about adenoids, turbinates, and the nasal septum. Finally, read about the use of Flonase nasal spray to treat your allergies. There is always something new to learn about in the world of sleep! Read More: Ways to Decrease Anxiety an...
Source: About Sleep Disorders - March 30, 2013 Category: Sleep Medicine Source Type: news

Actigraphic assessment of periodic leg movements in patients with restless legs syndrome
We examined 12 responders to dopaminergic treatment and 12 non‐responders and studied the association between response to dopaminergic treatment and the periodic limb movement index (PLMI) as assessed with actigraphy. Demographic characteristics, excessive daytime sleepiness and fatigue at baseline were similar in all three groups. Baseline RLS severity was similar between responders and non‐responders [International Restless Legs Severity Scale (IRLS): 25 ± 9 and 24 ± 8]. Group comparisons of PLMI before treatment initiation showed significant differences between the three groups. Post‐hoc pairwise comparisons...
Source: Journal of Sleep Research - March 26, 2013 Category: Neurology Authors: Maria A. T. Cippà, Christian R. Baumann, Massimiliano M. Siccoli, Claudio L. Bassetti, Rositsa Poryazova, Esther Werth Tags: Short Paper Source Type: research

Actigraphic assessment of periodic leg movements in patients with restless legs syndrome.
We examined 12 responders to dopaminergic treatment and 12 non-responders and studied the association between response to dopaminergic treatment and the periodic limb movement index (PLMI) as assessed with actigraphy. Demographic characteristics, excessive daytime sleepiness and fatigue at baseline were similar in all three groups. Baseline RLS severity was similar between responders and non-responders [International Restless Legs Severity Scale (IRLS): 25 ± 9 and 24 ± 8]. Group comparisons of PLMI before treatment initiation showed significant differences between the three groups. Post-hoc pairwise comparisons revea...
Source: Journal of Sleep Research - March 26, 2013 Category: Sleep Medicine Authors: Cippà MA, Baumann CR, Siccoli MM, Bassetti CL, Poryazova R, Werth E Tags: J Sleep Res Source Type: research

Restless Legs Syndrome in a Group of Patients With Alzheimer's Disease
Conclusion: RLS prevalence in our AD cohort was estimated to be about 4%. RLS appeared to be associated with neuropsychiatric symptoms such as apathy. RLS and apathy might share a common pathophysiological basis represented by a dysfunction of the central dopaminergic system (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - March 14, 2013 Category: Geriatrics Authors: Talarico, G., Canevelli, M., Tosto, G., Vanacore, N., Letteri, F., Prastaro, M., Troili, F., Gasparini, M., Lenzi, G. L., Bruno, G. Tags: Current Topic in Research Source Type: research

Prevalence of restless leg syndrome in subjects with depressive disorder.
CONCLUSION: RLS is prevalent in depressive disorder. However, onset of RLS is unrelated to age and number or duration of depressive disorders. PMID: 23439849 [PubMed] (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - March 9, 2013 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

Early childhood‐onset restless legs syndrome: symptoms and effect of oral iron treatment
ConclusionSymptoms of RLS may start as early as the first year of life, are accompanied by low ferritin levels and a high PLMSI and can be ameliorated by iron supplementation. An increased awareness and knowledge of RLS in early childhood are warranted. (Source: Acta Paediatrica)
Source: Acta Paediatrica - March 6, 2013 Category: Pediatrics Authors: Jens Tilma, Karen Tilma, Ole Norregaard, John R Ostergaard Tags: Regular Article Source Type: research

Drugs May Help Relieve Restless Legs Syndrome
Review found two types of approved medications helped most patients with moderate to severe symptoms (Source: WebMD Health)
Source: WebMD Health - March 4, 2013 Category: Consumer Health News Source Type: news

Drugs May Help Relieve Restless Legs Syndrome
Review found two types of approved medications helped most patients with moderate to severe symptomsSource: HealthDay Related MedlinePlus Pages: Medicines, Restless Legs (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 4, 2013 Category: Consumer Health News Source Type: news

Drugs Quiet Restless Legs at Night (CME/CE)
(MedPage Today) -- Patients with severe restless legs syndrome may experience symptomatic relief from the condition with two different types of pharmacologic agents, a meta-analysis confirmed. (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - March 4, 2013 Category: Psychiatry Source Type: news

How to get to sleep: Guardian readers' tips for a good night
Following research on the genetic changes caused by poor sleep, readers leave their tips for a good night's kipIn the wake of news that sleeping less than six hours a night skews the activity of hundreds of genes, readers have been sharing advice on how to get some decent shut-eye. ToBaldlyGo kicked off the conversation by pondering the merits of alcohol before bedtime. lhumphrey responded:@ToBaldlyGo - that's because having a drink at night "to get you to sleep" may knock you out but actually restricts your bodies ability to enter restorative, REM sleep throughout the night. You may have been asleep for longer but will ac...
Source: Guardian Unlimited Science - February 26, 2013 Category: Science Authors: Guardian readers Tags: Blogposts Genetics Health guardian.co.uk Medical research Human biology Society Life and style Sleep Science Source Type: news

Characteristics and determinants of restless legs syndrome in pregnancy: A prospective study
Conclusion: We found lower prevalence and earlier onset of symptoms compared to previous studies and confirmed significant improvement after delivery. RLS is clinically relevant due to severe impact on sleep quality. Genetic factors and smoking, but not ferritin, anemia, or estrogen levels, seem to play a role in the pathophysiology of RLS in pregnancy. (Source: Neurology)
Source: Neurology - February 18, 2013 Category: Neurology Authors: Hubner, A., Krafft, A., Gadient, S., Werth, E., Zimmermann, R., Bassetti, C. L. Tags: Restless legs syndrome, Cohort studies ARTICLE Source Type: research

Vascular Risk Factors, Cardiovascular Disease, and Restless Legs Syndrome in Women
Conclusions: In this large cohort of female health professionals, various vascular risk factors are associated with the prevalence of restless legs syndrome. We could not confirm the results of previous reports indicating an association between prevalent cardiovascular disease and restless legs syndrome. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Anke C. Winter, Markus Schürks, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Klaus Berger, Tobias Kurth Tags: Clinical research studies Source Type: research

Vascular Risk Factors, Cardiovascular Disease, and Restless Legs Syndrome in Men
Conclusions: The restless legs syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with restless legs syndrome. Prevalent stroke and myocardial infarction are related to restless legs syndrome prevalence. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Anke C. Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth Tags: Clinical research studies Source Type: research

Is Restless Legs Syndrome Associated with Cardiovascular Disease?
SEE RELATED ARTICLESpp. 220 and 228 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Rohit Budhiraja, Stuart F. Quan Tags: Editorials Source Type: research

AASM Updates Treatment Guidelines for Restless Legs Syndrome and Periodic Limb Movement Disorder.
PMID: 23418804 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - February 15, 2013 Category: Primary Care Authors: Armstrong C Tags: Am Fam Physician Source Type: research

Periodic Limb Movements in Sleep Contribute to Further Cardiac Structure Abnormalities in Hemodialysis Patients with Restless Legs Syndrome
Conclusions:These are the first data to associate severe PLMS with further LV structure abnormalities in HD patients with RLS.Citation:Giannaki CD; Zigoulis P; Karatzaferi C; Hadjigeorgiou GM; George KP; Gourgoulianis K; Koutedakis Y; Stefanidis I; Sakkas GK. Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. J Clin Sleep Med 2013;9(2):147–153. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - February 14, 2013 Category: Sleep Medicine Source Type: research

Determination of the Minimal Clinically Important Improvement in IRLS Total Score in Patients with Moderate to Severe Restless Legs Syndrome Treated with Rotigotine Transdermal System: A Post Hoc Analysis from a 6-Month Placebo-Controlled European Study (P02.056)
CONCLUSIONS: In patients with moderate to severe RLS, a 6 point reduction in the IRLS total score is felt to be clinically meaningful.Supported by: UCB Pharma, Smyrna, USA.Disclosure: Dr. Kohnen has received personal compensation for activities with UCB Pharma. Dr. Roth has received personal compensation for activities with Abbott, Accadia, AstraZeneca, Aventis, AVER, Bayer, Bristol-Myers Squibb Company, Cypress, GlaxoSmithKline, Inc., Impax, Intec, Jazz, Johnson & Johnson, Merck, Neurocrine, Novartis, Proctor and Gamble, Pfizer Inc, Purdue Pharma, Shire, Somaxon, and TransOral. Dr. Roth has received research support f...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Kohnen, R., Roth, T., Grieger, F., Moran, K., Ondo, W. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

The Long-Term Efficacy and Safety of Fluphenazine in Patients with Tourette Syndrome (P02.057)
CONCLUSIONS: Our study shows that fluphenazine is safe and effective in patients with TS. Although tardive dyskinesia is potential risk it did not occur in this large cohort of patients treated with fluphenazine for up to 16.8 years.Disclosure: Dr. Wijemanne has nothing to disclose. Dr. Jankovic has received personal compensation for activities with Allergan, Inc., Chelsea Therapeutics, EMD Serono, Merz Pharmaceuticals, Lundbeck, and Teva Neuroscience as a consultant. Dr. Jankovic has received personal compensation in an editorial capacity for Medlink: Neurology in Clinical Practice. Dr. Jankovic has received research supp...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Wijemanne, S., Jankovic, J. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Interim Analysis of an Open-Label, Multi-Center Study of Ecopipam, a Dopamine D1 Receptor Antagonist, for Tic Reduction in Adults with Tourette Syndrome (P02.058)
CONCLUSIONS: In this open-label study, oral ecopipam appeared to reduce tic severity without causing weight gain. To confirm treatment safety and efficacy, further double blind, placebo-controlled randomized trials in children and in adults with TS are warranted.Supported by: Psyadon Pharmaceuticals, Inc.Disclosure: Dr. Gilbert has received personal compensation in an editorial capacity for Pediatrics Review and Education Program. Dr. Gilbert has received research support from Psyadon Pharmaceuticals and Otsuka Pharmaceuticals. Dr. Budman has received research support from Psyadon Pharmaceuticals and Otsuka Pharmaceuticals...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Gilbert, D., Budman, C., Singer, H., Kurlan, R., Kwan, R., Chipkin, R. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Minimal Clinically Important Improvement in IRLS Total Score in Patients with Restless Legs Syndrome: A Post Hoc Analysis from a 6-Month Placebo-Controlled US-Based Study with Rotigotine Transdermal System (P02.059)
CONCLUSIONS: In patients with moderate to severe RLS, a 5 point reduction in IRLS total score is felt to be clinically meaningful.Supported by: UCB Pharma, Smyrna, USA.Disclosure: Dr. Ondo has received personal compensation for activities with Teva Neuroscience, Allergan, Inc., Ipsen, UCB Pharma, Merz Pharma, Lundbeck, and Novartis as a consultant. Dr. Roth has received personal compensation for activities with Abbott, Accadia, AstraZeneca, Aventis, AVER, Bayer, Bristol-Myers Squibb Company, Cypress, GlaxoSmithKline, Inc., Impax, Intec, Jazz, Johnson & Johnson, Merck, Neurocrine, Novartis, Proctor and Gamble, Pfizer In...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Ondo, W., Roth, T., Grieger, F., Moran, K., Kohnen, R. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Is Transcutaneous Spinal Direct Current Stimulation Efficient in Symptomatic Treatment of Patients with Idiopathic Restless Legs Syndrome? (P02.060)
CONCLUSIONS: Our data indicate that tsDCS is efficient in alleviating RLS symptoms and might become a completely new, non-pharmacological therapeutic tool for primary RLS patients.Supported by: German Restless Legs Syndrom patients' organization (RLS e.V.).Disclosure: Dr. Heide has nothing to disclose. Dr. Winkler has nothing to disclose. Dr. Nitsche has received personal compensation for activities with Neuroelectrics, Eisai, Inc., UCB Pharma, and GlaxoSmithKline, Inc. Dr. Nitsche has received research support from Eisai, Inc. UCB Pharma, and GlaxoSmithKline, Inc. Dr. Heide has received personal compensation for activitie...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Heide, A.-C., Winkler, T., Nitsche, M., Heide, W., Trenkwalder, C., Paulus, W., Bachmann, C. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Can Childhood Comorbidities Be Good Predictors of Functional Outcome in Adults with Tourette Syndrome? A Series of 140 Cases (P02.061)
CONCLUSIONS: In TS associated co-morbidities (ADD or OCD) do not predict functional outcome in adults compared to those without co-morbidities, however, further comprehensive age specific assessment of functional impairment in larger population might be necessary.Disclosure: Dr. Mainali has nothing to disclose. Dr. Velander has nothing to disclose. Dr. Lederman has nothing to disclose. Dr. Erenberg has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mainali, G., Velander, L., Lederman, R., Erenberg, G. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Secondary Blepharospasm Associated with Structural Lesions of the Brain (P02.062)
CONCLUSIONS: The basal ganglia are not the only region involved in the pathogensis of secondary blepharospasm. Instead, the available data support a network model, which proposes involvement of multiple areas. Abnormal function or communication between parts of this network causes irregularities in motor control manifesting as dystonia.Disclosure: Dr. Khoshnoodi has nothing to disclose. Dr. Factor has received personal compensation in an editorial capacity for Current Neurology and Neuroscience. Dr. Factor has received research support from Ceregene, Teva Neuroscience, Ipsen, and EMD Serono. Dr. Jinnah has received researc...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Khoshnoodi, M., Factor, S., Jinnah, H. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Bruxism Associated with Restless Limbs Syndrome (RLS): A Dopamine Responsive Movement Disorder (P02.063)
CONCLUSIONS: These data support a strong association between RLS and bruxism, both movement disorders and parasomnias, and suggests that bruxism, in this population, may respond to treatment with DAs. Although retrospective, non-controlled, and unblinded, this study should enhance disease appreciation and encourage a blinded and placebo-controlled trial of DA for bruxism associated with RLS. Finally, the data suggest that bruxism may be a manifestation of RLS and is a dopamine-responsive movement disorder that should be well-known to, and treated by, neurologists in the future.Disclosure: Dr. Dickoff has received personal ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Dickoff, D. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

A Possible Association between Fluticasone Propionate and Tics in Pediatric Asthmatic Patients: Two Case Reports and a Literature Review (P02.064)
CONCLUSIONS: Although this is the first case report suggesting a link between fluticasone and tics, it should nevertheless be considered in the differential diagnosis of transient motor tic development or exacerbation in the pediatric asthmatic population.Disclosure: Dr. Steele has nothing to disclose. Dr. Rosner has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Steele, M., Rosner, J. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Prevalence of Blepharospasm and Apraxia of Eyelid Opening in Patients with Parkinsonism, Cervical Dystonia and Essential Tremor (P02.065)
CONCLUSIONS: We conclude then, that BSP is common in parkinsonism and that BSP, is more prevalent in atypical parkinsonism. We also conclude that blepharospasm is not a common feature in essential tremor patients(0 out of 274 patients reported BSP symptoms).Disclosure: Dr. Kabir has nothing to disclose. Dr. Rana has nothing to disclose. Dr. Khondker has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Kabir, A., Rana, A., Khondker, S. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Prenatal and Perinatal Morbidity in Children with Tic Disorders. A Mainstream School-Based Population Study in Central Spain (P02.066)
CONCLUSIONS: Women with fetuses at risk for tic disorders should receive counseling to avoid smoking and cesarean section if possible, to minimize the odds of tic disorders.Supported by: SACYL, Biomedicine project GRS 157-A, Health Research Grant PI 070846, and the European General Development Co-funding.Disclosure: Dr. Cubo Delgado has received personal compensation for activities with Abbott and UCB Pharma. Dr. Hortigüela has nothing to disclose. Dr. Roldan has nothing to disclose. Dr. Ciciliani has nothing to disclose. Dr. Lopez has nothing to disclose. Dr. Velasco has nothing to disclose. Dr. Sastre has nothing to...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Cubo, E., Hortiguela, M., Roldan, S., Ciciliani, C., Lopez, P., Velasco, L., Sastre, E. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

A Tale of Two Restless Sisters (P02.067)
CONCLUSIONS: Rasagiline was well tolerated during the follow-up. We suggest that Rasagiline could represent a useful adjunct therapeutic option in the treatment of RLS.Disclosure: Dr. Alvarez has received personal compensation for activities with Teva Neurosciences, US World Meds, Pfizer Inc, Forrest Pharmaceuticals, and Medtronic. Dr. Grogan has received personal compensation for activities with US Worldmeds as a speaker. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Alvarez, M., Grogan, P. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

The Baroque and its influence on Willis’ description of restless legs syndrome
Restless legs syndrome (RLS) was first described in 1672 by Thomas Willis (1621–1675), a brilliant English physician who lived during the Baroque . The Baroque often is defined as the art or culture of the counter-reformation , an expression of specific values that were inherent to the conflicted state of the human soul during that time. The cardinal symptom of RLS is the imperious, compulsive, irresistible urge to move one’s legs . It is an inner disposition towards disquiet, which also is present in all artistic manifestations of the Baroque. The symptoms of RLS express the antitheses of rest and motion, calm and sto...
Source: Sleep Medicine - February 14, 2013 Category: Sleep Medicine Authors: Gilmar Fernandes do Prado, Luciane Bizari Coin de Carvalho, Karla Carlos, Lucila Bizari Fernandes do Prado Tags: Letters to the Editor Source Type: research

Vivid dreams may precede symptoms of restless legs syndrome
We report a 48-year-old man who had dreams of uncomfortable sensations in the legs once a week for the past 15years. During his dreams he had to run to get relief from symptoms, and when he was tired of running he had to rest. However, the unpleasant sensations in his legs would return, and he would have to run faster and faster to get relief from symptoms. When he woke up, he would have severe discomfort in his legs, similar to what he felt while he was dreaming. He had to move his legs and walk to improve the symptoms so that he could go back to sleep. He never experienced unpleasant sensations in his legs when he went t...
Source: Sleep Medicine - February 11, 2013 Category: Sleep Medicine Authors: Luis F. Marin, Gilmar F. Prado Tags: Letters to the Editor Source Type: research

Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson's disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire
Conclusion: Our results indicate a significant impact of RBD co-morbidity on night-time disturbances and quality of life in PD, particularly on cognition and emotional well-being. RBDSQ may be a useful tool for not only screening RBD in PD patients but also predicting diffuse and complex clinical PD phenotypes associated with RBD, cognitive impairment and hallucinations. (Source: BMC Neurology)
Source: BMC Neurology - February 9, 2013 Category: Neurology Authors: Keisuke SuzukiTomoyuki MiyamotoMasayuki MiyamotoYuka WatanabeShiho SuzukiMuneto TatsumotoMasaoki IwanamiTsubasa SadaTaro KadowakiAyaka NumaoKenichi HashimotoHideki SakutaKoichi Hirata Source Type: research

Novel assessment of microvascular changes in idiopathic restless legs syndrome (Willis–Ekbom disease)
Summary Many patients with restless legs syndrome (Willis–Ekbom disease) complain of burning sensations in their feet associated with the desire to move, such that they seek cooler environments. This pilot study aimed to characterise the microvascular skin changes in 12 patients with restless legs syndrome compared with 12 age‐ and sex‐matched controls. Patients with moderate or severe restless legs syndrome and controls underwent detailed thermovascular assessment in a controlled temperature room at three different stages (normothermic phase 23 °C, hot phase 30 °C, cold phase 18 °C). Microvascular activity was...
Source: Journal of Sleep Research - February 9, 2013 Category: Neurology Authors: Kirstie N. Anderson, Costanzo Di Maria, John Allen Tags: Regular Research Paper Source Type: research

Novel assessment of microvascular changes in idiopathic restless legs syndrome (Willis-Ekbom disease).
Abstract Many patients with restless legs syndrome (Willis-Ekbom disease) complain of burning sensations in their feet associated with the desire to move, such that they seek cooler environments. This pilot study aimed to characterise the microvascular skin changes in 12 patients with restless legs syndrome compared with 12 age- and sex-matched controls. Patients with moderate or severe restless legs syndrome and controls underwent detailed thermovascular assessment in a controlled temperature room at three different stages (normothermic phase 23 °C, hot phase 30 °C, cold phase 18 °C). Microvascular activity ...
Source: Journal of Sleep Research - February 9, 2013 Category: Sleep Medicine Authors: Anderson KN, Maria CD, Allen J Tags: J Sleep Res Source Type: research

Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson¿s disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire
Conclusion: Our results indicate a significant impact of RBD co-morbidity on night-time disturbances and quality of life in PD, particularly on cognition and emotional well-being. RBDSQ may be a useful tool for not only screening RBD in PD patients but also predicting diffuse and complex clinical PD phenotypes associated with RBD, cognitive impairment and hallucinations. (Source: BMC Neurology)
Source: BMC Neurology - February 9, 2013 Category: Neurology Authors: Keisuke SuzukiTomoyuki MiyamotoMasayuki MiyamotoYuka WatanabeShiho SuzukiMuneto TatsumotoMasaoki IwanamiTsubasa SadaTaro KadowakiAyaka NumaoKenichi HashimotoHideki SakutaKoichi Hirata Source Type: research

Restless legs syndrome in end‐stage renal disease: a multicenter study in Taiwan
ConclusionsOur findings demonstrated that RLS is common in Taiwanese dialysis patients. Clinicians should have a high suspicion for the presence of RLS symptoms in patients with ESRD, especially those with type 2 diabetes, anemia, low serum iron status and long duration of dialysis. (Source: European Journal of Neurology)
Source: European Journal of Neurology - February 1, 2013 Category: Neurology Authors: C.‐H. Lin, V.‐C. Wu, W.‐Y. Li, H.‐N. Sy, S.‐L. Wu, C.‐C. Chang, P.‐F. Chiu, H.‐H. Lion, C.‐Y. Lin, H.‐W. Chang, S.‐Y. Lin, K.‐D. Wu, Y.‐M. Chen, R.‐M. Wu Tags: Original Article Source Type: research

A time sequence analysis of the relationship between cardiovascular risk factors, vascular diseases and restless legs syndrome in the general population
Summary Previous cross‐sectional studies regarding the association of restless legs syndrome (RLS) with cardiovascular morbidity are controversial. Our aim was to evaluate prospectively the relationship of cardiovascular risk factors and vascular diseases with incident RLS in the general population. The results are from two prospective population‐based cohort studies: the Dortmund Health Study (n = 1312, median follow‐up of 2.1 years) and the Study of Health in Pomerania (n = 4308, median follow‐up of 5.0 years). RLS status was assessed twice according to the minimal criteria. Diabetes, hypertension, myocardi...
Source: Journal of Sleep Research - February 1, 2013 Category: Neurology Authors: András Szentkirályi, Henry Völzke, Wolfgang Hoffmann, Svenja Happe, Klaus Berger Tags: Regular Research Paper Source Type: research