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Outcome In Head And Neck Cancer Predicted By Genetic Diversity Within Tumors
A new measure of the heterogeneity - the variety of genetic mutations - of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. In the May 20 issue of the journal Cancer, investigators at Massachusetts General Hospital (MGH) and Massachusetts Eye and Ear Infirmary describe how their measure was a better predictor of survival than most traditional risk factors in a small group of patients with squamous cell carcinoma of the head and neck... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 21, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Study Suggests Cutaneous Squamous Cell Carcinoma Carries Risk Of Metastasis And Death
JAMA Dermatology Study Highlights A study by Chrysalyne D. Schmults, M.D., M.S.C.E., of Brigham and Women's Hospital, Boston, and colleagues suggests cutaneous squamous cell carcinoma (CSCC) carries a low but significant risk of metastasis and death. The ten-year retrospective cohort study was conducted at an academic medical center in Boston, and included 985 patients with 1,832 tumors. Main measures of the study were subhazard ratios for local recurrence, nodal metastasis, disease-specific death, and all-cause death adjusted for presence of known prognostic risk factors... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Risky Squamous Cell Skin Cancers Can Kill (CME/CE)
(MedPage Today) -- Most cutaneous squamous cell carcinomas are easily treated surgically, but patients with specific disease risk factors develop metastases and ultimately die of the disease, a retrospective study determined. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - May 16, 2013 Category: Consumer Health News Source Type: news
Human Papillomavirus, p16, and Epidermal Growth Factor Receptor Biomarkers and CT Perfusion Values in Head and Neck Squamous Cell Carcinoma [HEAD & NECK]
CONCLUSIONS: A significant correlation exists between CTP measures and EGFR overexpression in head and neck squamous cell carcinomas, suggesting an association between certain imaging findings and molecular biomarkers. These results may be related to a tumor cell survival mechanism linking perfusion and biomarker expression. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - May 15, 2013 Category: Radiology Authors: Hoefling, N. L., McHugh, J. B., Light, E., Kumar, B., Walline, H., Prince, M., Bradford, C., Carey, T. E., Mukherji, S. K. Tags: HEAD & amp; NECK Source Type: research
UV‐induced occupational skin cancer: possibilities of secondary individual prevention in the “Dermatologist's Procedure”
Summary Invasive squamous cell carcinoma (SCC) as a “quasi occupational disease” according to §9 Section 2 of the German Social Code Book (SGB) VII typically develops on chronically UV‐damaged skin from actinic keratoses. After the Medical Scientific Committee of the Federal Ministry of Labor and Social Affairs has confirmed the legal criteria for acknowledging UV‐induced SCC as an occupational disease, it is expected that the condition will be added to the official list of occupational diseases issued by the Federal Government in the near future. The Social Accident Insurance is required by law (§3 Occupational ...
Source: JDDG - May 14, 2013 Category: Dermatology Authors: Peter Elsner, Otto Blome, Thomas Ludwig Diepgen Tags: Review Source Type: research
Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results Data, 1973 to 2009
CONCLUSIONSThe current findings point to racial disparities in the incidence of PNSSCC and, to a lesser extent, in the outcome of patients with PNSSCC. Although there has been a decline in the proportion of patients presenting with advanced PNSSCC, the overall survival remained stable over time. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - May 14, 2013 Category: Cancer & Oncology Authors: Benjamin Ansa, Michael Goodman, Kevin Ward, Scott A. Kono, Taofeek K. Owonikoko, Kristin Higgins, Jonathan J. Beitler, William Grist, Trad Wadsworth, Mark El‐Deiry, Amy Y. Chen, Fadlo Raja Khuri, Dong M. Shin, Nabil F. Saba Tags: Original Article Source Type: research
A rare presentation of multiple primary squamous cell carcinoma of the tongue in a patient with recurrent hepatitis C infection
ABSTRACT Hepatitis C virus (HCV) infection has been implicated as a risk factor for development of oral squamous cell carcinoma (SCC). Multiple primary sites of oral SCC associated with HCV infection occurs infrequently. This case report describes a rare presentation of multiple primary SCCs of the tongue in a patient with recurrent HCV cirrhosis status post liver transplant that required interdisciplinary medical and surgical management. It is important for oral health care providers to understand the local and systemic implications of HCV infection and perform routine clinical examinations to monitor for development of o...
Source: Special Care in Dentistry - May 14, 2013 Category: Dentistry Authors: Eric T. Stoopler, Ying Wai Sia, Ara A. Chalian, Bert W. O'Malley, Faizan Alawi Tags: Case History Report Source Type: research
Malignant Odontogenic Tumors: A Multicentric Latin American Study Of 25 Cases
ConclusionAs malignant odontogenic tumors are very rare, this series helps to better clarify their relative frequency, predominant subtypes and clinical characteristics in Latin America.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)
Source: Oral Diseases - May 14, 2013 Category: ENT & OMF Authors: Marisol Martínez Martínez, Adalberto Mosqueda‐Taylor, Román Carlos, Wilson Delgado Azañero, Oslei Paes Almeida Tags: Original Article Source Type: research
The clinical significance of subcarinal lymph node dissection in the radical resection of oesophageal cancer
CONCLUSIONS Tumour location, depth of invasion, pathological type, degree of differentiation and other factors are closely associated with subcarinal lymph node metastasis. Recurrence and metastasis after oesophageal dissection are more likely with subcarinal lymph node metastasis. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - May 14, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Ma, H., Li, Y., Ding, Z., Liu, X., Xu, J., Qin, J. Tags: Thoracic Source Type: research
The presentation and management of mandibular tumors in the pediatric population
ConclusionsMalignant mandibular tumors in children are most often sarcomas but can include other rare lesions. Free flap reconstruction is a reasonable option for even very young children requiring extensive mandibular surgery. Level of Evidence4.Laryngoscope, 2013 (Source: The Laryngoscope)
Source: The Laryngoscope - May 13, 2013 Category: ENT & OMF Authors: Margo McKenna Benoit, Sara O. Vargas, Neil Bhattacharyya, Trevor A. McGill, Caroline D. Robson, Nalton Ferraro, Amanda E. Didas, Brian I. Labow, Joseph Upton, Amir Taghinia, John G. Meara, Karen J. Marcus, Jennifer Mack, Carlos Rodriguez‐Galindo, Reza R Tags: Pediatrics Source Type: research
Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
JAK2 activity is tightly controlled through a self-inhibitory effect via its JAK homology domain 2 (JH2), which restricts the strength and duration of JAK2/STAT3 signaling under physiological conditions. Although multiple mutations within JAK2, which abrogate the function of JH2 and sustain JAK2 activation, are widely observed in hematological malignancies, comparable mutations have not been detected in solid tumors. How solid tumor cells override the autoinhibitory effect of the JH2 domain to maintain constitutive activation of JAK2/STAT3 signaling remains puzzling. Herein, we demonstrate that AGK directly interacted with...
Source: Journal of Clinical Investigation - May 12, 2013 Category: Biomedical Science Authors: Xiuting Chen, Zhe Ying, Xi Lin, Huanxin Lin, Jueheng Wu, Mengfeng Li, Libing Song Source Type: research
Pemetrexed versus erlotinib in pretreated patients with advanced non–small cell lung cancer: A Hellenic Oncology Research Group (HORG) randomized phase 3 study
CONCLUSIONSBoth pemetrexed and erlotinib had comparable efficacy in pre‐treated patients with metastatic NSCLC, and the current results indicated that genotyping of tumor cells may have an important effect on treatment efficacy. Cancer 2013; © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - May 9, 2013 Category: Cancer & Oncology Authors: Athanasios Karampeazis, Alexandra Voutsina, John Souglakos, Nikos Kentepozidis, Stelios Giassas, Charalambos Christofillakis, Athanasios Kotsakis, Pavlos Papakotoulas, Ageliki Rapti, Maria Agelidou, Sofia Agelaki, Lambros Vamvakas, George Samonis, Dimitri Tags: Original Article Source Type: research
SERPINB2 down‐regulation contributes to chemoresistance in head and neck cancer
In this study, using genome‐wide gene expression analysis to investigate potential molecular mediators of HNSCC chemoresistance, we identified SERPINB2, a known inhibitor of extracellular serine proteinase urokinase‐type plasminogen activator (uPA), as an important candidate. Whereas SERPINB2 is known to function as a suppressor of uPA molecular cascades, many of which play important roles in tumor invasion and metastasis, a role for SERPINB2 in cancer drug resistance has not been examined. By using quantitative real‐time PCR and Western blot analysis, we determined that SERPINB2 mRNA and protein levels correlated wi...
Source: Molecular Carcinogenesis - May 9, 2013 Category: Molecular Biology Authors: Zhiquan Huang, Haigang Li, Qi Huang, Dan Chen, Jingjing Han, Lili Wang, Chanbin Pan, Weiliang Chen, Michael G. House, Kenneth P. Nephew, Zhongmin Guo Tags: Research Article Source Type: research
Cancer‐associated missense mutations of CASP8 activate NF‐κB signaling
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - May 9, 2013 Category: Cancer & Oncology Authors: Mizuo Ando, Masahito Kawazu, Toshihide Ueno, Kazutaka Fukumura, Azusa Yamato, Manabu Soda, Yoshihiro Yamashita, Young Lim Choi, Tatsuya Yamasoba, Hiroyuki Mano Tags: Original Article Source Type: research
Immunohistochemical detection of Helicobacter pylori without association of TLR5 expression in oral squamous cell carcinoma
ConclusionsFor the first time, this study provides evidence that immunohistochemically detected HP expression in OSCC is associated with reduced disease‐free survival in a large patient cohort. Although TLR5 was not associated with any clinicopathological characteristics or impact on survival, investigation of the TLR family seems to be reasonable due to the possible existence of other pathogenic bacterial or viral compounds in oral cavity cancer. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 9, 2013 Category: Pathology Authors: Martin Grimm, Adelheid Munz, Alexandros Exarchou, Joachim Polligkeit, Siegmar Reinert Tags: Original Article Source Type: research
Prognostic impact of postoperative radiation in patients undergoing radical esophagectomy for pathologic lymph node positive esophageal cancer
Conclusions: This large retrospective analysis supports the use of PORT for pathologic lymph node positive stage III esophageal squamous cell carcinoma. Given the retrospective nature of this study, the results should be confirmed by appropriately powered randomized trials. Further development of adjuvant therapy in EC is warranted. (Source: Radiation Oncology)
Source: Radiation Oncology - May 8, 2013 Category: Cancer & Oncology Authors: Yaping XuJinshi LiuXianghui DuXiaojiang SunYuanda ZhengJianxiang ChenBo LiWei LiuHao JiangWeimin Mao Source Type: research
5% fluorouracil chemowraps in the management of widespread lower leg solar keratoses and squamous cell carcinoma
Abstract Elderly patients with extensive hypertrophic solar keratoses and squamous cell carcinoma on the lower legs can pose significant management challenges. Typically these patients require surgical treatment which is complicated by comorbidities and poor background lower leg skin. 5% fluorouracil chemowraps provides a useful alternative technique for the management of diffuse hypertrophic solar keratoses and as an adjuvant, and in some situations as a palliative treatment, for squamous cell carcinomas on the lower legs. (Source: Australasian Journal of Dermatology)
Source: Australasian Journal of Dermatology - May 8, 2013 Category: Dermatology Authors: Ben Tallon, Nicholas Turnbull Tags: Brief Report Source Type: research
Laser photodynamic treatment for in situ squamous cell carcinoma of the glans monitored by reflectance confocal microscopy
We present the first case of in situ penile SCC treated with laser PDT, where the efficacy of the treatment was monitored by reflectance confocal microscopy (RCM) using a handheld camera. In the future RCM may be regarded as a complementary technique to assess the efficacy of non‐surgical treatment of mucous membrane cancers. (Source: Australasian Journal of Dermatology)
Source: Australasian Journal of Dermatology - May 8, 2013 Category: Dermatology Authors: Elisa Cinotti, Jean Luc Perrot, Bruno Labeille, Catherine Douchet, Nicolas Mottet, Frédéric Cambazard Tags: Brief Report Source Type: research
Can radiological changes in lymph node volume during treatment predict success of radiation therapy in patients with locally advanced head and neck squamous cell carcinoma?
ConclusionsChanges in nodal volume are minimal initially during RT but accelerate during the latter weeks of therapy. This study suggests that chemotherapy achieves a greater decrease in nodal volume than EGFR inhibitors and that nodal changes do not predict disease control in the neck. (Source: Australasian Radiology)
Source: Australasian Radiology - May 8, 2013 Category: Radiology Authors: Sanju Mishra, Alexander Hammond, Nancy Read, Varagur Venkatesan, Eric Winquist, Anthony Nichols, Andrew Warner, David Palma Tags: Radiation Oncology—Original Article Source Type: research
The role of globular heads of the C1q receptor in HPV 16 E2-induced human cervical squamous carcinoma cell apoptosis is associated with p38 MAPK/JNK activation
Conclusion: These data support a mechanism whereby HPV 16 E2 induces apoptosis by silencing the gC1qR gene or inhibiting p38 MAPK/JNK signalling in cervical squamous cell carcinoma. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - May 8, 2013 Category: Research Authors: Ling-juan GaoPing-qing GuWei ZhaoWen-yan DingXue-qing ZhaoShu-yu GuoTian-ying Zhong Source Type: research
Researchers discover possible trigger for spread of head and neck cancer cells
UCLA RESEARCH ALERT FINDINGS: Very little has been known about the epigenetic events — developmental and environmental factors affecting genes — that occur prior to the invasive growth of head and neck squamous cell carcinomas and their spread to other parts of the body, or metastasis. However, researchers from the UCLA School of Dentistry discovered what could be a crucial step toward understanding the process that activates the cancer cells. Squamous cell carcinoma is known for being one of the most deadly and debilitating types of tumors. Led by Dr. Cun-Yu Wang, a UCLA School of Dentistry profe...
Source: UCLA Newsroom: Health Sciences - May 7, 2013 Category: Universities & Medical Training Source Type: news
Brief S2k guidelines – Cutaneous squamous cell carcinoma
Source: JDDG - May 7, 2013 Category: Dermatology Authors: Helmut Breuninger, Thomas Eigentler, Friedrich Bootz, Axel Hauschild, Rolf‐Dieter Kortmann, Klaus Wolff, Eggert Stockfleth, Rolf‐Markus Szeimies, Rainer Rompel, Claus Garbe, Stephan Grabbe Tags: Cutaneous squamous cell carcinoma Source Type: research
Self‐expanding plastic stent removed after radiochemotherapy for advanced esophageal cancer
Summary Endoscopic evaluation after chemoradiotherapy (CR) is impossible with an esophageal stent in place. The main study objective was to evaluate self‐expanding plastic stent (SEPS) removal post‐CR. Secondary end‐points were the improvement of dysphagia and patients' quality of life. From October 2008 to March 2011, 20 dysphagic patients who suffered from advanced esophageal cancer were enrolled in a multicenter, prospective study. SEPS was inserted prior to CR and then removed endoscopically. SEPS efficiency (dysphagia score) and tolerance, as well as the patients' quality of life (European Organization for the R...
Source: Diseases of the Esophagus - May 7, 2013 Category: Gastroenterology Authors: A. Laquière, P. Grandval, D. Heresbach, F. Prat, J. P. Arpurt, P. Bichard, P.‐N. D'Halluin, J. Berthillier, C. Boustière, R. Laugier Tags: Original article Source Type: research
Prognostic molecular markers in cancer ‐ Quo vadis? ‐Lessons learned from studies on oral cancer
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - May 7, 2013 Category: Pathology Authors: Tine M. Søland, Ingvild J. Brusevold Tags: Review Source Type: research
Repression of G protein–coupled receptor family C group 5 member A is associated with pathologic differentiation grade of oral squamous cell carcinoma
ConclusionsGPRC5A is expressed in normal oral epithelium. Repression of GPRC5A is associated with poorly differential grade of OSCCs. Overexpression of GPRC5A in OSCC cell line reversed the malignant phenotype. Thus, GPRC5A is important for homeostasis in oral tissue, and deletion or repression of this gene may involve in tumorigenesis of OSCCs and may serve as a prognostic marker for malignant type of OSCCs. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 7, 2013 Category: Pathology Authors: Shu‐li Liu, Shuang‐shuang Zhong, Dong‐xia Ye, Wan‐tao Chen, Zhi‐yuan Zhang, Jiong Deng Tags: Original Article Source Type: research
The presence of old pulmonary tuberculosis is an independent prognostic factor for squamous cell lung cancer survival
Conclusion: The presence of an old pulmonary TB lesion may be an important prognostic factor for predicting the survival of squamous cell carcinoma patients. (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - May 6, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Yiming ZhouZhenling CuiXiao ZhouChang ChenSen JiangZhongyi HuGening Jiang Source Type: research
The Natural History of Actinic Keratosis: A Systematic Review
ConclusionsIn general, the available data are limited. Important methodological limitations apply. Currently, no reliable estimates concerning the frequency of AKs developing into invasive carcinoma can be given, further studies are needed.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - May 6, 2013 Category: Dermatology Authors: R.N. Werner, A. Sammain, R. Erdmann, V. Hartmann, E. Stockfleth, A. Nast Tags: Review Article Source Type: research
MicroRNA profiling in locally advanced esophageal cancer indicates a high potential of miR‐192 in prediction of multimodality therapy response
Abstract In order to identify possible predictive markers, this study aimed to characterize miRNA profiles of responder and non‐responder in the multimodality therapy of locally advanced esophageal cancer. Initially a microarray‐based approach was performed including eight patients with esophageal cancer. Patients received neoadjuvant chemoradiation followed by surgical resection. Major histopathological response was defined if resected specimens contained less than 10% vital tumor cells (major/minor response: 4/4 patients). Intratumoral RNA was isolated from both, pre‐therapeutic tissue biopsies in addition to corre...
Source: International Journal of Cancer - May 5, 2013 Category: Cancer & Oncology Authors: M. Odenthal, E. Bollschweiler, P.P. Grimminger, W. Schröder, J. Brabender, U. Drebber, A.H. Hölscher, R. Metzger, D. Vallböhmer Tags: Cancer Therapy Source Type: research
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
Nature advance online publication 05 May 2013. doi:10.1038/nature12124 Authors: Unnur Styrkarsdottir, Gudmar Thorleifsson, Patrick Sulem, Daniel F. Gudbjartsson, Asgeir Sigurdsson, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Asmundur Oddsson, Agnar Helgason, Olafur T. Magnusson, G. Bragi Walters, Michael L. Frigge, Hafdis T. Helgadottir, Hrefna Johannsdottir, Kristin Bergsteinsdottir, Margret H. Ogmundsdottir, Jacqueline R. Center, Tuan V. Nguyen, John A. Eisman, Claus Christiansen, Erikur Steingrimsson, Jon G. Jonasson, Laufey Tryggvadottir, Gudmundur I. Eyjolfsson, Asgeir Theodors, Thorvaldur Jonsson, Thorvaldur Ingvarss...
Source: Nature AOP - May 5, 2013 Category: Research Authors: Unnur StyrkarsdottirGudmar ThorleifssonPatrick SulemDaniel F. GudbjartssonAsgeir SigurdssonAslaug JonasdottirAdalbjorg JonasdottirAsmundur OddssonAgnar HelgasonOlafur T. MagnussonG. Bragi WaltersMichael L. FriggeHafdis T. HelgadottirHrefna JohannsdottirKr Tags: Letter Source Type: research
Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - May 4, 2013 Category: Cancer & Oncology Authors: Manabu Shigeoka, Naoki Urakawa, Tetsu Nakamura, Mari Nishio, Taketo Watajima, Daisuke Kuroda, Takahide Komori, Yoshihiro Kakeji, Shuho Semba, Hiroshi Yokozaki Tags: Original Article Source Type: research
Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - May 4, 2013 Category: Cancer & Oncology Authors: Yosuke Makuuchi, Kazufumi Honda, Yoshiaki Osaka, Ken Kato, Takashi Kojima, Hiroyuki Daiko, Hiroyasu Igaki, Yoshinori Ito, Sumito Hoshino, Shingo Tachibana, Takafumi Watanabe, Koh Furuta, Shigeki Sekine, Tomoko Umaki, Yukio Watabe, Nami Miura, Masaya Ono, Tags: Original Article Source Type: research
HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia
Conclusions: HPV prevalence (82%) in cervical cancer is at the lower range of the worldwide estimation (85 - 99%). While XRCC1 G399A was significantly associated with cervical cancer, TP53 G72C showed borderline association only in HPV-positive patients. Deviation from HWE in HPV-positive patients indicates co-selection, hence implicating the combination of HPV and SNPs in cancer predisposition. Thus, SNPs could be more relevant biomarkers of susceptibility to cervical cancer when associated with HPV infection. (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - May 4, 2013 Category: Cancer & Oncology Authors: Ghazi AlsbeihNajla Al-HarbiMedhat El-SebaieIsmail Al-Badawi Source Type: research
Re‐evaluation of common paradigms regarding the clinical appearance of oral mucosal malignancies
ConclusionWithin this study sample, non‐ulcerated masses rather than indurate ulcers are the most common clinical appearance of oral mucosal malignancies, and even for SCC, that showed the highest ulceration rate at presentation, half were non‐ulcerated. Approximately, one‐third of oral mucosal malignancies were not suspected to be malignant prior to biopsy. Thus, the level of suspicion currently reserved for mucosal ulcers and ulcerated masses should also be applied to non‐ulcerated oral mucosal masses. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - May 4, 2013 Category: Pathology Authors: Irit Allon, Dror M. Allon, Gavriel Gal, Yakir Anavi, Gavriel Chaushu, Ilana Kaplan Tags: Original Article Source Type: research
HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas
High-risk types of human papilloma virus (HPV) are increasingly associated with oropharyngeal squamous cell carcinoma (OPSCC). Strikingly, patients with HPV-positive OPSCC are highly curable with ionizing radiation and have better survival compared with HPV-negative patients, but the underlying molecular mechanisms remain poorly understood. We applied an array-based approach to monitor global changes in CpG island hypermethylation between HPV-negative and HPV-positive OPSCCs and identified a specific pattern of differentially methylated regions that critically depends on the presence of viral transcripts. HPV-related alter...
Source: Journal of Clinical Investigation - May 3, 2013 Category: Biomedical Science Authors: Efterpi Kostareli, Dana Holzinger, Olga Bogatyrova, Thomas Hielscher, Gunnar Wichmann, Michaela Keck, Bernd Lahrmann, Niels Grabe, Christa Flechtenmacher, Christopher R. Schmidt, Tanguy Seiwert, Gerhard Dyckhoff, Andreas Dietz, Daniela Höfler, Michae Source Type: research
Association of two BRM promoter polymorphisms with head and neck squamous cell carcinoma risk
The SWI/SNF chromatin remodeling complex is an important regulator of gene expression that has been linked to cancer development. Expression of Brahma (BRM), a critical catalytic subunit of SWI/SNF, is lost in a variety of solid tumors. Two novel BRM promoter polymorphisms (BRM-741 and BRM-1321) have been correlated with BRM loss and elevated cancer risk. The aim(s) of this study were to examine BRM expression in head and neck squamous cell carcinoma (HNSCC) and to correlate BRM polymorphisms with HNSCC risk. BRM expression studies were performed on eight HNSCC cell lines and 76 surgically resected tumor samples. A case&nd...
Source: Carcinogenesis - May 3, 2013 Category: Cancer & Oncology Authors: Wang, J. R., Gramling, S. J. B., Goldstein, D. P., Cheng, D., Chen, D., Azad, A. K., Tse, A., Hon, H., Chen, Z., Mirshams, M., Simpson, C., Huang, S. H., Marquez, S., O'Sullivan, B., Liu, F.-F., Roberts, H., Xu, W., Brown, D. H., Gilbert, R. W., Gullane, Tags: Original Manuscript Source Type: research
DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification
This study supports the value of the expression profiling of the components of the miRNA-processing machinery in the prognosis of NSCLC patients, especially DROSHA expression levels. In addition, differential expression of miRNAs, such as hsa-let-7a and miR-16 may be helpful tools in the histologic subclassification of NSCLC. (Source: Carcinogenesis)
Source: Carcinogenesis - May 3, 2013 Category: Cancer & Oncology Authors: Diaz-Garcia, C. V., Agudo-Lopez, A., Perez, C., Lopez-Martin, J. A., Rodriguez-Peralto, J. L., de Castro, J., Cortijo, A., Martinez-Villanueva, M., Iglesias, L., Garcia-Carbonero, R., Fresno Vara, J. A., Gamez-Pozo, A., Palacios, J., Cortes-Funes, H., Paz Tags: Original Manuscript Source Type: research
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau
Epidemiological studies of underground miners suggested that occupational exposure to radon causes lung cancer with squamous cell carcinoma (SCC) as the predominant histological type. However, the genetic determinants for susceptibility of radon-induced SCC in miners are unclear. Double-strand breaks induced by radioactive radon daughters are repaired primarily by non-homologous end joining (NHEJ) that is accompanied by the dynamic changes in surrounding chromatin, including nucleosome repositioning and histone modifications. Thus, a molecular epidemiological study was conducted to assess whether genetic variation in 16 ge...
Source: Carcinogenesis - May 3, 2013 Category: Cancer & Oncology Authors: Leng, S., Picchi, M. A., Liu, Y., Thomas, C. L., Willis, D. G., Bernauer, A. M., Carr, T. G., Mabel, P. T., Han, Y., Amos, C. I., Lin, Y., Stidley, C. A., Gilliland, F. D., Jacobson, M. R., Belinsky, S. A. Tags: Original Manuscript Source Type: research
Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma
We examined the association between genetic variants in sex hormone metabolic genes and ESCC risk in a population from north central China with high-incidence rates. A total of 1026 ESCC cases and 1452 controls were genotyped for 797 unique tag single-nucleotide polymorphisms (SNPs) in 51 sex hormone metabolic genes. SNP-, gene- and pathway-based associations with ESCC risk were evaluated using unconditional logistic regression adjusted for age, sex and geographical location and the adaptive rank truncated product (ARTP) method. Statistical significance was determined through use of permutation for pathway- and gene-based ...
Source: Carcinogenesis - May 3, 2013 Category: Cancer & Oncology Authors: Hyland, P. L., Freedman, N. D., Hu, N., Tang, Z.-Z., Wang, L., Wang, C., Ding, T., Fan, J.-H., Qiao, Y.-L., Golozar, A., Wheeler, W., Yu, K., Yuenger, J., Burdett, L., Chanock, S. J., Dawsey, S. M., Tucker, M. A., Goldstein, A. M., Abnet, C. C., Taylor, P Tags: Original Manuscript Source Type: research
Basal stem cells contribute to squamous cell carcinomas in the oral cavity
The cells of origin of oral cavity squamous cell carcinoma (OCSCC) are unknown. We used a cell lineage tracing approach (adult K14-CreERTAM; ROSA26 mice transiently treated with tamoxifen) to identify and track normal epithelial stem cells (SCs) in mouse tongues by X-gal staining and to determine if these cells become neoplastically transformed by treatment with a carcinogen, 4-nitroquinoline 1-oxide (4-NQO). Here, we show that in normal tongue epithelia, X-gal(+) cells formed thin columns throughout the entire epithelium 12 weeks after tamoxifen treatment, indicating that the basal layer contains long-lived SCs that produ...
Source: Carcinogenesis - May 3, 2013 Category: Cancer & Oncology Authors: Tang, X.-H., Scognamiglio, T., Gudas, L. J. Tags: Original Manuscript Source Type: research
High CRP values predict poor survival in patients with penile cancer
Conclusions: A high preoperative serum CRP level was associated with poor survival in patients with penile cancer. If larger patient populations confirm its prognostic value, its routine use could enable better risk stratification and risk-adjusted follow-up of patients with SCC of the penis. (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2013 Category: Cancer & Oncology Authors: Sandra SteffensAndreas Al GhazalJulie SteinestelRieke LehmannGerd WegenerThomas SchnoellerMarcus CronauerFlorian JentzmikMark SchraderMarkus KuczykAndres Schrader Source Type: research
Stromal response in different histological grades of oral squamous cell carcinoma: A histochemical study
Conclusions: Tumor cells which grow progressively in the host stroma have the capacity to pre-empt and subvert the response of host, which is essential for their growth and spread. Clinical Relevance: The reactive changes in the tumor stroma may alter the biological aggressiveness of oral cancer, and by incorporating this concept into a prognostic system, we may help to reflect the biologic diversity of oral cancer and predict its clinical outcomes. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3) - May 3, 2013 Category: Dentistry Authors: Jiji GeorgeRamandeep Singh NarangNirmala N Rao Source Type: research
Elective lymph node irradiation late course accelerated hyper-fractionated radiotherapy plus concurrent cisplatin-based chemotherapy for esophageal squamous cell carcinoma: a phase II study
Conclusions: ENI LCAHRT concurrently with CHT was appeared to be an effective regimen for ESCC patient with a favorable and tolerated profile. Further observation with longer time and randomized phase III trial is currently underway.Trial registrationChiCTR-TRC-09000568URL/hyperlink: http://www.chictr.org/cn/proj/show.aspx?proj=832 (Source: Radiation Oncology)
Source: Radiation Oncology - May 2, 2013 Category: Cancer & Oncology Authors: Dongqing WangJiali YangJingyu ZhuBaosheng LiLimin ZhaiMingping SunHeyi GongTao ZhouYumei WeiWei HuangZhongtang WangHongsheng LiZicheng Zhang Source Type: research
EZH2, a unique marker of malignancy in effusion cytology
Distinguishing reactive mesothelial cells from metastatic disease, typically adenocarcinoma, in effusion cytology can be challenging at times. We currently use a panel of immunocytochemical markers for select cases including MOC‐31 and BerEp4, but difficulties still exist. Enhancer of zeste homologue 2 (EZH2) plays important roles in epigenetic silencing and cell cycle regulation and is upregulated in a wide variety of malignancies. Thus, we hypothesized that EZH2 immunocytochemistry, which to our knowledge has not yet been reported on cytology material, might serve as a unique marker of malignancy in morphologically equ...
Source: Diagnostic Cytopathology - May 2, 2013 Category: Pathology Authors: Huimiao Jiang, Raavi Gupta, Jonathan Somma Tags: Original Article Source Type: research
Radiosensitivity in HPV-Positive Head and Neck CancerRadiosensitivity in HPV-Positive Head and Neck Cancer
Increased radiosensitivity likely contributes to improved outcomes in patients human papillomavirus (HPV)-positive head and neck squamous cell carcinomas. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 1, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Histopathology showed this neoplasm to be a seborrheic keratosis: it might well have been a hypertrophic actinic keratosis, melanoma, or superficial basal or squamous cell carcinoma. (Source: Consultant Live)
Source: Consultant Live - May 1, 2013 Category: Primary Care Source Type: news
Cyclin D1‐induced proliferation is independent of Beta‐Catenin in Head and Neck Cancer
ConclusionTaken together, we show that the change in cyclin D1 levels is more likely to be due to the EGFR‐Akt pathway activation than due to beta‐catenin nuclear translocation.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)
Source: Oral Diseases - May 1, 2013 Category: ENT & OMF Authors: Katiuchia Uzzun Sales, Fernanda Giudice, Rogerio Castilho, Felipe T Salles, Cristiane Squarize, Aline Abrahao, Decio dos Santos Pinto Junior Tags: Original Article Source Type: research
Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness
This study examined PLCE1 expression by immunohistochemistry (IHC) from 110 ethnic Kazakh ESCC patients and 50 from adjacent normal esophageal tissues (NETs). The expressed PLCE1 was localized in cytoplasm, especially in the peripheral layers of cancer cell nests, which was significantly higher in tumors than in NETs (p < 0.001). Increased expression of PLCE1 was correlated with advanced tumor‐node‐metastasis (TNM) stages (p = 0.015) and lymph node metastasis (p = 0.003) in patients with ESCC. Of the 110 patients, we examined 50 paired ESCC tissues and corresponding NETs by quantitative RT‐PCR (polymerase ch...
Source: APMIS - May 1, 2013 Category: Research Authors: Yun‐Zhao Chen, Xiao‐Bin Cui, Jian‐Ming Hu, Wen Jie Zhang, Shu‐Gang Li, Lan Yang, Xi‐Hua Shen, Chun‐Xia Liu, Qing‐Fang Pan, Shi‐Ying Yu, Xiang‐Lin Yuan, Lei Yang, Wen‐Yi Gu, Jie‐Zhong Chen, Li‐Dong Wang, Feng Li Tags: Original Article Source Type: research
The oncogenic role of PTK7 in esophageal squamous cell carcinoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - May 1, 2013 Category: Cancer & Oncology Authors: Won‐Sik Shin, Junhye Kwon, Hae Won Lee, Moon Chul Kang, Hye‐Won Na, Seung‐Taek Lee, Jong Ho Park Tags: Original Article Source Type: research
[Articles] Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2×2 factorial trial
The results of our trial—the largest in anal cancer to date—show that fluorouracil and mitomycin with 50·4 Gy radiotherapy in 28 daily fractions should remain standard practice in the UK. (Source: The Lancet Oncology)
Source: The Lancet Oncology - April 30, 2013 Category: Cancer & Oncology Authors: Roger D James, Robert Glynne-Jones, Helen M Meadows, David Cunningham, Arthur Sun Myint, Mark P Saunders, Timothy Maughan, Alec McDonald, Sharadah Essapen, Martin Leslie, Stephen Falk, Charles Wilson, Simon Gollins, Rubina Begum, Jonathan Ledermann, Latha Tags: Articles Source Type: research
Genetic relationship between multiple squamous cell carcinomas arising in the oral cavity
ConclusionThe present data highlight the value of mtDNA analysis in establishing the clonal relationship between the index tumor and the second neoplastic lesion. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - April 30, 2013 Category: ENT & OMF Authors: Lucio Montebugnoli, Elisa Leonardi, Luca Morandi, Anna Farnedi, Davide Bartolomeo Gissi, Claudio Marchetti, Achille Tarsitano, Tiziana Balbi, Luciano Gentile, Roberto Cocchi, Maria Pia Foschini Tags: Original Article Source Type: research