Stem Cell Therapy
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[News of the Week] Cell Therapies: Clean Pigs Offer Alternative to Stem Cell Transplants
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Within a couple of years, a scientific team hopes to start clinical trials using cells from the first swine herd in the country specially bred to supply insulin-secreting pancreatic islets for people with diabetes. But they face immunological and regulatory challenges, as well as the challenge of overcoming public aversion to the idea.Author: Constance Holden (Source: Science: Current Issue)
Source: Science: Current Issue - November 20, 2009 Category: Science Authors: Constance Holden Source Type: journals
On your last nerve: Researchers advance understanding of stem cellsEmail this article to a colleague.
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Researchers have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance in understanding the development of the nervous system, which is essential to addressing conditions such as Parkinson's disease, Alzheimer's disease and other neurological disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 20, 2009 Category: Science Source Type: news
Selected Update: Cancer stem cells: Symmetry is keyEmail this article to a colleague.
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The tumor suppressor protein p53 regulates the polarity of mammary stem cell division. (Source: Nature Signaling Update)
Source: Nature Signaling Update - November 20, 2009 Category: Research Source Type: info
Systolic function of patients with myocardial infarction undergoing autologous bone marrow transplantationEmail this article to a colleague.
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CONCLUSION: Autologous mononuclear bone marrow cell transplantation did not improve the echocardiographic parameters of systolic function. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals
Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain.Email this article to a colleague.
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In this study, dual-label immunofluorescence analysis of the proliferation marker, Ki67, and the stem cell markers, nestin and Sox2, was performed on brains of 8 week-old wild-type (WT) and Cav-1 knockout (KO) mice. Our results demonstrate an increased number of Ki67-positive nuclei in the subventricular zone (SVZ) of Cav-1 KO brains. Importantly, our dual-label immunofluorescence analyses demonstrate increased co-localization of Ki67 with both nestin and Sox2 in the SVZ of Cav-1 KO brains. Remarkably similar results were also obtained with Cav-2 and Cav-3 KO mouse brains as well, with increased proliferation of adult neur...
Source: Cell Cycle - November 20, 2009 Category: Cytology Authors: Jasmin JF, Yang M, Iacovitti L, Lisanti MP Tags: Cell Cycle Source Type: journals
First reconstitution of an epidermis from human embryonic stem cellsEmail this article to a colleague.
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Researchers in France have just succeeded in recreating a whole epidermis from human embryonic stem cells. The goal is to one day be able to propose this unlimited resource of cells as an alternative treatment in particular for victims of third degree burns. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 20, 2009 Category: Science Source Type: news
Miller School Researchers Present Findings At AHA Scientific SessionsEmail this article to a colleague.
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A multidisciplinary team of clinical and basic science researchers in the Vascular Biology Institute at the University of Miami Miller School of Medicine has discovered a possible molecular signature of coronary artery disease in bone marrow stem cells. The dramatic findings were presented on November 16 at the American Heart Association's Scientific Sessions in Orlando. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Heart Disease Source Type: news
Miller School Researchers Present Findings At AHA Scientific SessionsEmail this article to a colleague.
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A multidisciplinary team of clinical and basic science researchers in the Vascular Biology Institute at the University of Miami Miller School of Medicine has discovered a possible molecular signature of coronary artery disease in bone marrow stem cells. The dramatic findings were presented on November 16 at the American Heart Association's Scientific Sessions in Orlando. Coronary artery disease remains the number one killer in the United States and much of the Western world. (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 20, 2009 Category: Cardiology Tags: Heart Disease Source Type: news
Burns Patients Awaiting Skin Grafts: Human Embryonic Stem-Cells Could Be Used To Generate Temporary SkinEmail this article to a colleague.
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A study in this week's edition of The Lancet reports that the use of human embryonic stem-cells (hESCs) is a promising alternative for producing temporary skin substitutes for patients awaiting skin grafts after, for example, serious burn injuries. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: stem cell Research Source Type: news
Burns Patients Awaiting Skin Grafts: Human Embryonic Stem-Cells Could Be Used To Generate Temporary SkinEmail this article to a colleague.
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A study in this week's edition of The Lancet reports that the use of human embryonic stem-cells (hESCs) is a promising alternative for producing temporary skin substitutes for patients awaiting skin grafts after, for example, serious burn injuries. The article is the work of Dr Christine Baldeschi, INSERM and Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Evry Cedex, France, and colleagues. (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - November 20, 2009 Category: Dermatology Tags: stem cell Research Source Type: news
University Weighs Tighter Limits on Stem Cell ResearchEmail this article to a colleague.
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The University of Nebraska would be the first such institution to set stricter limits than what national or state law allows. (Source: NYT > Health)
Source: NYT > Health - November 20, 2009 Category: Consumer Health News Authors: By MONICA DAVEY Tags: stem cells Colleges and Universities University of Nebraska Medicine and Health Research Source Type: news
Stem-Cell Debate Unlikely to Fade After Neb. VoteEmail this article to a colleague.
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OMAHA, Neb. (AP) -- The University of Nebraska's governing board was expected to vote Friday on a resolution that would limit stem-cell research at the university system's facilities to rules approved under former President George W. Bush. (Source: NYT > Stem Cells)
Source: NYT > Stem Cells - November 20, 2009 Category: Stem Cells Source Type: news
University Weighs Tighter Limits on Stem Cell ResearchEmail this article to a colleague.
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The University of Nebraska would be the first such institution to set stricter limits than what national or state law allows. (Source: NYT > Stem Cells)
Source: NYT > Stem Cells - November 20, 2009 Category: Stem Cells Source Type: news
New skin 'may help burns victims'Email this article to a colleague.
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French researchers say they have found a way of using human embryonic stem cells to create new skin which could help serious burns victims. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 20, 2009 Category: Consumer Health News Tags: Health Source Type: news
Stem cells: the first human trialEmail this article to a colleague.
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People suffering from a form of incurable blindness could soon become the first patients in the world to benefit from a new and controversial transplant operation using stem cells derived from spare human embryos left over from IVF treatment. (Source: The Independent - Science)
Source: The Independent - Science - November 20, 2009 Category: Science Tags: Science Source Type: news
Human skin grown from stem cells offers burns victims hopeEmail this article to a colleague.
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SCIENTISTS have transformed stem cells into human skin in a breakthrough that may revolutionise the treatment of burns victims. (Source: Scotsman.com News - Health)
Source: Scotsman.com News - Health - November 20, 2009 Category: Consumer Health News Source Type: news
[Comment] Bioengineered human skin from embryonic stem cellsEmail this article to a colleague.
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The therapeutic use of human embryonic stem cells (hESCs) is currently prevented by several important hurdles. These hurdles include the availability of well-characterised, appropriately monitored cell lines that can be specified into the required lineages reproducibly and efficiently, without resulting in tumour formation or eliciting an immune response resulting in rejection. However, recent progress has provided hope that these challenges are not insurmountable and might eventually result in the use of hESCs for regenerative therapies for various diseases, including spinal cord injury, Parkinson's disease, and major tis...
Source: LANCET - November 20, 2009 Category: Journals (General) Authors: Holger Schlüter, Pritinder Kaur Tags: Comment Source Type: journals
[Articles] Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical studyEmail this article to a colleague.
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Cell therapy for large burns is dependent upon autologous epidermis reconstructed in vitro. However, the effectiveness of current procedures is limited by the delay needed to culture the patient's own keratinocytes. To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells' capability of constructing a pluristratified epidermis. (Source: LANCET)
Source: LANCET - November 20, 2009 Category: Journals (General) Authors: Hind Guenou, Xavier Nissan, Fernando Larcher, Jessica Feteira, Gilles Lemaitre, Manoubia Saidani, Marcela Del Rio, Christine C Barrault, François-Xavier Bernard, Marc Peschanski, Christine Baldeschi, Gilles Waksman Tags: Articles Source Type: journals
To be, or not to be?Email this article to a colleague.
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EMBO Reports. doi:10.1038/embor.2009.244
Author: Katrien Devolder
Are induced pluripotent stem cells potential babies, and does it matter? (Source: EMBO Reports AOP)
Source: EMBO Reports AOP - November 20, 2009 Category: Research Authors: Katrien Devolder Tags: Science & Society Source Type: journals
Paper round: FridayEmail this article to a colleague.
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Stem cell therapy for eyes, epilepsy as an art form, and moreRelated items from OnMedicaSwine flu prompts warning over critical care beds shortagesNICE draft guidance rejects use of cancer liver drugDaily alcohol consumption can lower heart diseaseGPs fail to consider their own end-of-life careNew osteoporosis risk scores highly effective (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 20, 2009 Category: UK Health Source Type: news
Enhanced treatment of articular cartilage defect of the knee by intra-articular injection of Bcl-xL-engineered mesenchymal stem cells in rabbit modelEmail this article to a colleague.
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We examined whether the transduction of an anti-apoptotic protein, Bcl-xL, into MSCs could prevent cell death and improve the implantation efficiency of MSCs in a rabbit model. Our current findings demonstrate that the group treated with Bcl-xL-engineered MSCs could improve cartilage healing both morphologically and histologically when compared with the controls. These results suggest that intra-articular injection of Bcl-xL-engineered MSCs is a potential non-invasive therapeutic method for effectively treating cartilage defects of the knee. Copyright © 2009 John Wiley & Sons, Ltd. (Source: Journal of Tissue Engineering a...
Source: Journal of Tissue Engineering and Regenerative Medicine - November 20, 2009 Category: Molecular Biology Authors: Bin Hu, Jun-Lin Ren, Jun-Rui Zhang, Qin Ma, Yan-Pu Liu, Tian-Qiu Mao Source Type: journals
New 'Skin' from Stem CellsEmail this article to a colleague.
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Technique used in mice may offer hope to burn patients awaiting grafts Source: HealthDay
Related MedlinePlus Topics: Burns, Stem Cells (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 20, 2009 Category: Consumer Health News Source Type: consumer
First human trials for stem cell blindness therapyEmail this article to a colleague.
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The first human trials of a stem cell therapy for an eye disease that causes blindness in young people could start next year. (Source: Telegraph Health)
Source: Telegraph Health - November 19, 2009 Category: Consumer Health News Tags: blindness human trials stem cell fda Source Type: news
Stem cell therapy for age-related retinal diseaseEmail this article to a colleague.
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Aging Health , December 2009, Vol. 5, No. 6, Pages 799-811. (Source: Future Medicine: Aging Health)
Source: Future Medicine: Aging Health - November 19, 2009 Category: Geriatrics Tags: article Source Type: journals
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesisEmail this article to a colleague.
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Neutrophils play a vital role in the immune defense, which is evident by the severity of neutropenia causing life-threatening infections. Granulocyte macrophage-colony stimulating factor (GM-CSF) controls homeostatic and emergency development of granulocytes. However, little is known about the contribution of the downstream mediating transcription factors signal transducer and activator of transcription 5A and 5B (STAT5A/B). To elucidate the function of this pathway, we generated mice with complete deletion of both Stat5a/b genes in hematopoietic cells. In homeostasis, peripheral neutrophils were markedly decreased in thes...
Source: Blood - November 19, 2009 Category: Hematology Authors: Kimura, A., Rieger, M. A., Simone, J. M., Chen, W., Wickre, M. C., Zhu, B.-M., Hoppe, P. S., O'Shea, J. J., Schroeder, T., Hennighausen, L. Tags: Hematopoiesis and stem cells, Phagocytes, Granulocytes, and Myelopoiesis Source Type: journals
Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profilingEmail this article to a colleague.
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The first adult-repopulating hematopoietic stem cells (HSCs) are detected starting at day 10.5 of gestation in the aorta-gonads-mesonephros (AGM) region of the mouse embryo. Despite the importance of the AGM in initiating HSC production, very little is currently known about the regulators that control HSC emergence in this region. We have therefore further defined the location of HSCs in the AGM and incorporated this information into a spatial and temporal comparative gene expression analysis of the AGM. The comparisons included gene expression profiling (1) in the newly identified HSC-containing region compared with the r...
Source: Blood - November 19, 2009 Category: Hematology Authors: Mascarenhas, M. I., Parker, A., Dzierzak, E., Ottersbach, K. Tags: Hematopoiesis and stem cells Source Type: journals
The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafishEmail this article to a colleague.
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The nuclear protein FOG-1 binds transcription factor GATA-1 to facilitate erythroid and megakaryocytic maturation. However, little is known about the function of FOG-1 during myeloid and lymphoid development or how FOG-1 expression is regulated in any tissue. We used in situ hybridization, gain- and loss-of-function studies in zebrafish to address these problems. Zebrafish FOG-1 is expressed in early hematopoietic cells, as well as heart, viscera, and paraspinal neurons, suggesting that it has multifaceted functions in organogenesis. We found that FOG-1 is dispensable for endoderm specification but is required for endoderm...
Source: Blood - November 19, 2009 Category: Hematology Authors: Amigo, J. D., Ackermann, G. E., Cope, J. J., Yu, M., Cooney, J. D., Ma, D., Langer, N. B., Shafizadeh, E., Shaw, G. C., Horsely, W., Trede, N. S., Davidson, A. J., Barut, B. A., Zhou, Y., Wojiski, S. A., Traver, D., Moran, T. B., Kourkoulis, G., Hsu, K., Tags: Hematopoiesis and stem cells Source Type: journals
Md. stem cell panel sees record interest for research grantsEmail this article to a colleague.
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The Maryland Stem Cell Research Commission received nearly 200 proposals for state-funded research grants, the highest number of applications to date in a year when there is less money available. (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - November 19, 2009 Category: American Health Source Type: journals
Md. stem cell panel sees record interest for research grantsEmail this article to a colleague.
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The Maryland Stem Cell Research Commission received nearly 200 proposals for state-funded research grants, the highest number of applications to date in a year when there is less money available. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 19, 2009 Category: Biotechnology Source Type: journals
Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination [LETTERS]Email this article to a colleague.
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Embryonic stem (ES) cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling cascades. How external signaling pathways connect to core self-renewal transcriptional circuits is largely unknown. To probe this, we chose BMP signaling, which is previously recognized as a master control for both self-renewal and lineage commitment of murine ES cells. Here, we mapped target gene promoter occupancy of SMAD1/5 and SMAD4 on a genome-wide scale and found that they associate with a large group of developmental regulators that are enriched for H3K27 trimethy...
Source: Genome Research - November 19, 2009 Category: Genetics & Stem Cells Authors: Fei, T., Xia, K., Li, Z., Zhou, B., Zhu, S., Chen, H., Zhang, J., Chen, Z., Xiao, H., Han, J.-D. J., Chen, Y.-G. Tags: LETTERS Source Type: journals
The effect of titanium particles on rat bone marrow stem cells in vitroEmail this article to a colleague.
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(Source: Toxicology Mechanisms and Methods)
Source: Toxicology Mechanisms and Methods - November 19, 2009 Category: Toxicology Authors: Meng, BoChen, JunjieGuo, DaweiYe, QingsongLiang, Xing Source Type: journals
Company seeks to test stem cells for blindnessEmail this article to a colleague.
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WASHINGTON (Reuters) - Advanced Cell Technology, a small Massachusetts-based biotechnology company, said on Thursday it has asked for approval to test human embryonic stem cells in treating a rare cause of blindness. (Source: Reuters: Health)
Source: Reuters: Health - November 19, 2009 Category: Consumer Health News Tags: healthNews Source Type: news
Systems-level dynamic analyses of fate change in murine embryonic stem cellsEmail this article to a colleague.
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Whetton & Ihor R. Lemischka
Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction between epigenetic, transcriptional and translational mechanisms. It is unclear how these different molecular regulatory mechanisms interact to regulate changes in stem cell fate. Here we present a dynamic systems-level study of cell fate change in murine ESCs following a well-defined perturbation. Global changes in histone acetylation, chromatin-bound RNA polymerase II, messenger RNA (mRNA), and nuclear protein levels were measured over 5 days after downregulation of Nanog, a key pluripotency re...
Source: Nature - November 19, 2009 Category: Research Authors: Rong LuFlorian MarkowetzRichard D. UnwinJeffrey T. LeekEdoardo M. AiroldiBen D. MacArthurAlexander LachmannRoye RozovAvi Ma’ayanLaurie A. BoyerOlga G. TroyanskayaAnthony D. WhettonIhor R. Lemischka Tags: Letter Source Type: journals
P.E.I. toddler battles cancer in TorontoEmail this article to a colleague.
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A two-year-old Summerside girl with tumours in her abdomen, ribcage, skull and leg bones is undergoing a stem cell transplant in Toronto in hopes of beating the cancer. (Source: CBC | Health)
Source: CBC | Health - November 19, 2009 Category: Consumer Health News Source Type: news
Beyond genomics, biologists and engineers decode the next frontierEmail this article to a colleague.
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Biologists and engineers have dramatically improved the speed and accuracy of measuring an enigmatic set of proteins that influences almost every aspect of how cells and tissues function. The new method offers a long-sought tool for studying stem cells, cancer and other problems of fundamental importance to biology and medicine. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 19, 2009 Category: Science Source Type: news
Is Hepatic Differentiation Of Embryonic Stem Cells Induced By Valproic Acid And Cytokines?Email this article to a colleague.
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Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. (Source: Transplants / Organ Donations News From Medical News Today)
Source: Transplants / Organ Donations News From Medical News Today - November 19, 2009 Category: Transplant Surgery Tags: Liver Disease / Hepatitis Source Type: news
Is Hepatic Differentiation Of Embryonic Stem Cells Induced By Valproic Acid And Cytokines?Email this article to a colleague.
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Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
International Event At Queen's Focuses On Male InfertilityEmail this article to a colleague.
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Male infertility and tackling falling birth rates across Europe will be among the topics addressed at this year's British Andrology Society's annual conference at Queen's University in Belfast. World leaders in the field of andrology - the study of male reproduction - will meet at Queen's this week (Thursday and Friday) to discuss the latest developments in the field of fertility including the potential to create artificial sperm from stem cells. (Source: Fertility News From Medical News Today)
Source: Fertility News From Medical News Today - November 19, 2009 Category: OBGYN Tags: Fertility Source Type: news
Persistent non-neoplastic gammadelta-T cells in cerebrospinal fluid of a patient with hepatosplenic (gammadelta) T cell lymphoma: a case report with 6 years of flow cytometry follow-up.Email this article to a colleague.
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We describe a case of a 31-year old man diagnosed with a gammadelta HSTCL in 2003, successfully treated with chemotherapy and allogeneic stem cell transplantation, and followed from 2003 to present. Four-color flow cytometry (FC) was performed on a BD FACSCalibur and data analyzed with CellQuest Pro and FCS Express software. For cerebrospinal fluid (CSF), all cells were acquired due to limited material. Cytological correlation was available on all specimens. Molecular studies for T-cell gene rearrangement were non-contributory. By FC, the diagnostic HSTCL immunophenotype was CD3 (+), CD7 (+), CD2 (+), CD5 (-), CD4 (-), CD8...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Jiang L, Abati AD, Wilson W, Stetler-Stevenson M, Yuan C Tags: Int J Clin Exp Pathol Source Type: journals
Transplanting People's Own Stem Cells Into Heart Lessens Pain, Improves Ability To WalkEmail this article to a colleague.
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The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Heart Disease Source Type: news
NC State Researchers Advance Understanding Of Stem CellsEmail this article to a colleague.
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Researchers from North Carolina State University have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance in understanding the development of the nervous system, which is essential to addressing conditions such as Parkinson's disease, Alzheimer's disease and other neurological disorders. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: stem cell Research Source Type: news
Transplanting People's Own Stem Cells Into Heart Lessens Pain, Improves Ability To WalkEmail this article to a colleague.
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The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells. (Source: Pain / Anesthetics News From Medical News Today)
Source: Pain / Anesthetics News From Medical News Today - November 19, 2009 Category: Anesthesiology Tags: Heart Disease Source Type: news
NC State Researchers Advance Understanding Of Stem CellsEmail this article to a colleague.
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Researchers from North Carolina State University have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance in understanding the development of the nervous system, which is essential to addressing conditions such as Parkinson's disease, Alzheimer's disease and other neurological disorders. (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 19, 2009 Category: Geriatrics Tags: stem cell Research Source Type: news
Stem Cells May Be Used as Skin GraftsEmail this article to a colleague.
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Human embryonic stem cells can be used to produce skin grafts for people who have been seriously burned, a study shows. (Source: WebMD Health)
Source: WebMD Health - November 19, 2009 Category: Consumer Health News Source Type: news
First reconstitution of an epidermis from human embryonic stem cellsEmail this article to a colleague.
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(INSERM (Institut national de la santé et de la recherche médicale)) Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM Institute, published in the Lancet on Nov. 21, 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.The goal is to one day be able to propose this unlimited resource of cells as an alternative treatment in particular for victims of third degree burns. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news
How plant stem cells guard against genetic damageEmail this article to a colleague.
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Scientists have shown how plants can protect themselves against genetic damage caused by environmental stresses. The growing tips of plant roots and shoots have an in-built mechanism that, if it detects damage to the DNA, causes the cell to "commit suicide" rather than pass on its defective DNA. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 19, 2009 Category: Science Source Type: news
Successful umbilical cord blood stem cell transplantation in a child with WHIM syndromeEmail this article to a colleague.
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(Source: European Journal of Haematology)
Source: European Journal of Haematology - November 19, 2009 Category: Hematology Authors: Gergely Kriván, Melinda Erdős, Krisztián Kállay, Gábor Benyó, Ágnes Tóth, János Sinkó, Vera Goda, Beáta Tóth, László Maródi Source Type: journals
Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypesEmail this article to a colleague.
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mp; Sebastian Brandner (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - November 19, 2009 Category: Research Authors: Thomas S JacquesAlexander SwalesMonika J BrzozowskiNico V HenriquezJacqueline M LinehanZaman MirzadehCatherine O' MalleyHeike NaumannArturo Alvarez-BuyllaSebastian Brandner Tags: Article Source Type: journals
Hydrodynamic modulation of embryonic stem cell differentiation by rotary orbital suspension cultureEmail this article to a colleague.
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Embryonic stem cells (ESCs) can differentiate into all somatic cell types, but the development of effective strategies to direct ESC fate is dependent upon defining environmental parameters capable of influencing cell phenotype. ESCs are commonly differentiated via cell aggregates referred to as embryoid bodies (EBs), but current culture methods, such as hanging drop and static suspension, yield relatively few or heterogeneous populations of EBs. Alternatively, rotary orbital suspension culture enhances EB formation efficiency, cell yield, and homogeneity without adversely affecting differentiation. Thus, the objective of ...
Source: Biotechnology and Bioengineering - November 19, 2009 Category: Biomedical Science Authors: Carolyn Y. Sargent, Geoffrey Y. Berguig, Melissa A. Kinney, Luke A. Hiatt, Richard L. Carpenedo, R. Eric Berson, Todd C. McDevitt Source Type: journals
Initial activation of EpCAM cleavage via cell-to-cell contactEmail this article to a colleague.
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Conclusions:
Activation of EpCAM's cleavage and oncogenic capacity is dependent on cellular interaction (juxtacrine) to provide for initial signals of regulated intramembrane proteolysis, which then support signalling via soluble EpEX (paracrine). (Source: BMC Cancer)
Source: BMC Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Sabine DenzelDorothea MaetzelBrigitte MackCarola EggertGabriele BaerrOlivier Gires Source Type: journals
