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This page shows you the latest news and research items in this category.

The role of OCT4 immunohistochemistry in evaluation of retroperitoneal lymph node dissections: a pilot study
& Liang Cheng (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 14, 2013 Category: Pathology Authors: Muhammad T IdreesSean R WilliamsonTheodore W KiefferLiang Cheng Tags: germ cell tumors immunohistochemistry lymph node dissection micrometastases OCT4 seminoma Source Type: research

Solitary Bony Metastasis in Seminoma [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 29, 2013 Category: Cancer & Oncology Authors: Wudhikarn, Colling, Robinson, Vaena Tags: DIAGNOSIS IN ONCOLOGY Source Type: research

Transcriptome profiling of mice testes following low dose irradiation
Conclusions: The five clusters represent gene expression in distinct cell types of the adult testis. We observed large expression changes in the somatic cell profile, which mainly could be attributed to changes in cellularity, but hyperplasia of Leydig cells may also play a role. We speculate that the possible hyperplasia may be caused by lower testosterone production and inadequate inhibin signalling due to missing germ cells. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 28, 2013 Category: Endocrinology Authors: Kirstine BellingMasami TanakaMarlene Danner DalgaardJohn Erik NielsenHenrik Bjørn NielsenSøren BrunakKristian AlmstrupHenrik Leffers Source Type: research

Frequency of computed tomography examinations in the follow-up care of testicular cancer patients - an evaluation of patterns of care in Germany.
CONCLUSION: There is a considerable gap between recommendation and actual performance regarding the number of CT scans applied to testicular cancer patients. Unfamiliarity of clinicians with guidelines as well as poor acceptance of high numbers of CT scans scheduled may have contributed to create this particular pattern of care. PMID: 23548967 [PubMed - in process] (Source: Onkologie)
Source: Onkologie - May 24, 2013 Category: Cancer & Oncology Authors: Rusner C, Stang A, Dieckmann KP, Friedel H Tags: Onkologie Source Type: research

Curcumin inhitis AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro.
Conclusion:Curcumin induces apoptosis and inhibits proliferation in NTera-2 cells via the inhibition of AP-2γ-mediated downstream cell survival signaling pathways. PMID: 23685957 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 20, 2013 Category: Drugs & Pharmacology Authors: Zhou C, Zhao XM, Li XF, Wang C, Zhang XT, Liu XZ, Ding XF, Xiang SL, Zhang J Tags: Acta Pharmacol Sin Source Type: research

Clinical outcomes in patients with stage I non-seminomatous germ cell cancer.
This study assesses the long-term outcomes in Han Chinese patients with clinical stage I non-seminomatous germ cell testicular cancer (CSI NSGCT) treated with surveillance, retroperitoneal lymph node dissection (RPLND) and adjuvant chemotherapy. We retrospectively evaluated 89 patients with a mean age of 26.5 years. After orchiectomy, 37 patients were treated with surveillance, 34 underwent RPLND and 18 were managed with chemotherapy. The overall survival rate, the recurrence-free survival rate and the risk factors were evaluated. The median follow-up length was 92 months (range: 6-149 months). Thirteen of the 89 patients ...
Source: Asian Journal of Andrology - May 20, 2013 Category: Urology & Nephrology Authors: Lv ZJ, Wu S, Dong P, Yao K, He YY, Gui YT, Zhou FJ, Liu ZW, Cai ZM Tags: Asian J Androl Source Type: research

Genomics Studies Identify Testicular Cancer Risk Variants
Two genome-wide studies have identified a total of 12 new genetic loci associated with a higher risk of testicular cancer. The risk-associated genetic variations could help clinicians single out higher-risk men for screening and early detection. (Source: Cancer Network)
Source: Cancer Network - May 17, 2013 Category: Cancer & Oncology Source Type: news

Early Stage Testicular Cancer - Surveillance Is Best Follow-Up Strategy
A long-term study of men with stage I seminoma, a common form of testicular cancer, suggests that surveillance for cancer recurrence, rather than additional chemotherapy or radiation therapy, is sufficient for the vast majority of patients who have undergone successful surgery for their cancer. In a new long-term study conducted in Denmark, researchers analyzed a national clinical database and found that 99.6% of patients who only underwent surveillance (following a successful surgery) were alive after 10 years of being diagnosed with testicular cancer... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

ASCO: Surveillance for Early Seminoma Found Safe
CHICAGO (MedPage Today) -- Most men with stage I seminoma can safely enter surveillance and avoid unnecessary therapy without jeopardizing survival, according to data from a large registry. (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - May 16, 2013 Category: Surgery Source Type: news

Surveillance Sufficient After Surgery in Early SeminomaSurveillance Sufficient After Surgery in Early Seminoma
Survival after surgery in stage I seminoma is excellent, and new data show that surveillance is sufficient for most patients. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 16, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Postsurgical surveillance sufficient for men with stage I seminoma
(Source: HemOncToday.com)
Source: HemOncToday.com - May 15, 2013 Category: Cancer & Oncology Source Type: news

4 New Genetic Risk Factors Identified For Testicular Cancer
A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The findings from this first-of-its-kind meta-analysis were reported online in Nature Genetics by researchers at the Perelman School of Medicine at the University of Pennsylvania... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 14, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Genetic Risk Factors for Testicular Cancer
(Ivanhoe Newswire) – Researchers from the Perelman School of Medicine at the University of Pennsylvania recently discovered four genetic variations strongly linked to an increased risk of testicular cancer. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - May 14, 2013 Category: Consumer Health News Source Type: news

Scientists Discover More Genetic Clues to Testicular Cancer
Title: Scientists Discover More Genetic Clues to Testicular CancerCategory: Health NewsCreated: 5/12/2013 2:35:00 PMLast Editorial Review: 5/13/2013 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - May 13, 2013 Category: Cancer & Oncology Source Type: news

Scientists Discover More Genetic Clues to Testicular Cancer
Disease risk is strongly tied to family history (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - May 12, 2013 Category: Cancer & Oncology Source Type: news

Excess deaths among seminoma patients persist
US research shows that men diagnosed with stage I seminoma since the advent of contemporary radiotherapy have a significantly increased risk for all-cause mortality compared with the overall population, despite being unlikely to die from testicular cancer itself. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - May 12, 2013 Category: Cancer & Oncology Source Type: news

Excess deaths among seminoma patients persist
US research shows that men diagnosed with stage I seminoma since the advent of contemporary radiotherapy have a significantly increased risk for all-cause mortality compared with the overall population, despite being unlikely to die from testicular cancer itself. (Source: MedWire News - Urology)
Source: MedWire News - Urology - May 12, 2013 Category: Urology & Nephrology Source Type: news

Scientists Discover More Genetic Clues to Testicular Cancer
Disease risk is strongly tied to family history (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 12, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Reproductive Medicine, Research, News, Source Type: news

Second to fourth digit ratio, handedness and testicular germ cell tumors
Conclusions: These results do not support the hypothesis that prenatal hormonal imbalance is associated with TGCT risk. Given the limited sample size, further evaluation of the relationship between TGCT and prenatal hormonal factors using digit ratio, ΔR−L, or left-hand dominance and larger sample size are warranted. (Source: Early Human Development)
Source: Early Human Development - May 12, 2013 Category: Perinatology & Neonatology Authors: Britton Trabert, Barry I. Graubard, Ralph L. Erickson, Yawei Zhang, Katherine A. McGlynn Source Type: research

Penn Medicine researchers identify 4 new genetic risk factors for testicular cancer
(University of Pennsylvania School of Medicine) A new study in Nature Genetics looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 12, 2013 Category: Global & Universal Source Type: news

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
Nature Genetics 45, 686 (2013). doi:10.1038/ng.2635 Authors: Elise Ruark, Sheila Seal, Heather McDonald, Feng Zhang, Anna Elliot, KingWai Lau, Elizabeth Perdeaux, Elizabeth Rapley, Rosalind Eeles, Julian Peto, Zsofia Kote-Jarai, Kenneth Muir, Jeremie Nsengimana, Janet Shipley, D Timothy Bishop, Michael R Stratton, Douglas F Easton, Robert A Huddart, Nazneen Rahman & Clare Turnbull Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) analysis of 307,2...
Source: Nature Genetics - May 12, 2013 Category: Genetics & Stem Cells Authors: Elise RuarkSheila SealHeather McDonaldFeng ZhangAnna ElliotKingWai LauElizabeth PerdeauxElizabeth RapleyRosalind EelesJulian PetoZsofia Kote-JaraiKenneth MuirJeremie NsengimanaJanet ShipleyD Timothy BishopMichael R StrattonDouglas F EastonRobert A Huddart Tags: Letter Source Type: research

Patterns of Management and Surveillance Imaging for Stage I Testicular Cancer amongst Medical Oncologists in Australia
ConclusionWe found considerable variation in management. The infrequent use of surveillance and frequent use of carboplatin for seminoma differs from international guidelines.Radiation exposure from CT imaging should be reduced through standardised follow‐up protocols, and possibly by alternate imaging modalities if validated in appropriate studies. (Source: BJU International)
Source: BJU International - May 9, 2013 Category: Urology & Nephrology Authors: P Grimison, B Houghton, M Chatfield, GC Toner, ID Davis, J Martin, E Hovey, M R Stockler Tags: Urological Oncology Source Type: research

Men's experiences of sexuality after cancer: a material discursive intra-psychic approach.
Abstract Men can experience significant changes to their sexuality following the onset of cancer. However, research on men's sexuality post-cancer has focused almost exclusively on those with prostate and testicular cancer, despite evidence that the diagnosis and treatment for most cancers can impact on men's sexuality. This Australian qualitative study explores the experiences of changes to sexuality for 21 men across a range of cancer types and stages, sexual orientations and relationship contexts. Semi-structured interviews were analysed with theoretical thematic analysis guided by a material discursive intra-ps...
Source: Culture, Health and Sexuality - May 8, 2013 Category: Global & Universal Authors: Gilbert E, Ussher JM, Perz J, Wong WK, Hobbs K, Mason C Tags: Cult Health Sex Source Type: research

Testis Cancer Rates Continue to Rise (CME/CE)
SAN DIEGO (MedPage Today) -- The incidence of testicular cancer continued its puzzling rise through the end of the last decade, according to a study reported here. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 7, 2013 Category: Hematology Source Type: news

Testicular Cancer on Rise in U.S., Especially Among Hispanic Men
Study finds slow, steady increase, but experts say condition remains uncommon (Source: WebMD Health)
Source: WebMD Health - May 3, 2013 Category: Consumer Health News Source Type: news

Testicular Cancer on Rise in U.S., Especially Among Hispanic Men
Study finds slow, steady increase, but experts say condition remains uncommon (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 3, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Reproductive Medicine, Preventive Medicine, News, Source Type: news

Testicular Cancer on Rise in U.S., Especially Among Hispanic Men
Title: Testicular Cancer on Rise in U.S., Especially Among Hispanic MenCategory: Health NewsCreated: 5/3/2013 12:35:00 PMLast Editorial Review: 5/3/2013 12:00:00 AM (Source: MedicineNet Mens Health General)
Source: MedicineNet Mens Health General - May 3, 2013 Category: Primary Care Source Type: news

Testicular Cancer on Rise in U.S., Especially Among Hispanic Men
Study finds slow, steady increase, but experts say condition remains uncommon (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - May 2, 2013 Category: Cancer & Oncology Source Type: news

Laparoscopic lumbar-aortic lymphadenectomy in residual post-chemotherapy tumours in testicular cancer.
CONCLUSIONS: In experienced hands, L-OLAL is a technically feasible surgical alternative for the treatment of patients who are carriers of advanced testicular cancer with residual post-chemotherapy masses. The dissection performed should be bilateral to avoid tumour relapses and increase the survival rate of these patients. PMID: 23643570 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - May 2, 2013 Category: Urology & Nephrology Authors: Castillo OA, Landerer E, Vidal-Mora I Tags: Actas Urol Esp Source Type: research

Cancer incidence, hospital morbidity, and mortality in young adults in Brazil.
Abstract There are still relatively few studies in the world on cancer incidence and mortality in young adults. The current study aimed to explore cancer distribution in young adults in Brazil. A descriptive study was conducted on cancer incidence (selected State capitals), hospital morbidity, and mortality (Brazil and selected capitals) in the 20-24-year age strata in 2000-2002, and trends in cancer mortality rates in Brazil in 1980-2008 in the same population. Testicular cancer was the principal anatomical site in young adult males; in young adult women, the main sites were thyroid, uterine cervix, and Hodgkin di...
Source: Cadernos de Saude Publica - May 1, 2013 Category: Global & Universal Authors: Santos SD, Melo LR, Koifman RJ, Koifman S Tags: Cad Saude Publica Source Type: research

The Study of DNA Methylation of in Urological Cancer: Present and Future.
CONCLUSIONS: The study of aberrant DNA methylation in biological specimens of patients has an enormous potential for the early diagnosis and screening of genitourinary neoplasms. A larger number of studies is needed to be able to define the series of genes that would mean unequivocal signatures of malignancy. This methodology also has potential when defining prognostic groups and potential of response to different therapies. PMID: 23643196 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - May 1, 2013 Category: Urology & Nephrology Authors: Andrés G, Ashour N, Sánchez-Chapado M, Ropero S, Angulo JC Tags: Actas Urol Esp Source Type: research

Preservation of sperm of cancer patients: extent of use and pregnancy outcome in a tertiary infertility center.
In conclusion, the rate of use of cryopresseved sperm in cancer patients is relatively low (10.3%). Achievement of pregnancies by ICSI presents the best option but when there are enough stored sperm samples and adequate quality, IUI can be employed. Cryopreservation is nevertheless the best option to preserve future fertility potential and hope for cancer patients. PMID: 23524529 [PubMed - in process] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - May 1, 2013 Category: Urology & Nephrology Authors: Botchan A, Karpol S, Lehavi O, Paz G, Kleiman SE, Yogev L, Yavetz H, Hauser R Tags: Asian J Androl Source Type: research

Outcomes in stage I testicular seminoma: A population‐based study of 9193 patients
CONCLUSIONSModern radiotherapy as applied in this large population‐based study is not associated with excess CVD mortality. Although increased all‐cause mortality exists, cumulative SMN risk is considerably smaller than reported in historical series, but additional follow‐up will be required to characterize long‐term trends. The increased risk of suicide, previously unreported in men with stage I seminoma, requires confirmation. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - April 30, 2013 Category: Cancer & Oncology Authors: Clair J. Beard, Lois B. Travis, Ming‐Hui Chen, Nils D. Arvold, Paul L. Nguyen, Neil E. Martin, Deborah A. Kuban, Andrea K. Ng, Karen E. Hoffman Tags: Original Article Source Type: research

Distribution of pituitary adenylate cyclase‐activating polypeptide (PACAP) in the human testis and in testicular germ cell tumors
Summary Pituitary adenylate cyclase‐activating peptide (PACAP) is a neuropeptide expressed in the central nervous system and peripheral organs. Previous studies revealed the role and distribution of PACAP in the rodent testis, however, its presence in the human testis and in testicular germ cell tumors is not known. We used RT‐PCR and immunohistological observations to investigate whether human testicular tissue and testicular germ cell tumors contain PACAP. The mRNAs for PACAP and its receptors were detected in total RNA extracted from human testes. PACAP immunoreactivity was observed in spermatogonia and spermatids f...
Source: Andrologia - April 28, 2013 Category: Urology & Nephrology Authors: K. Nakamura, T. Nakamachi, K. Endo, K. Ito, T. Machida, T. Oka, M. Hori, K. Ishizaka, S. Shioda Tags: Original Article Source Type: research

Tumor in undescended intrapelvic testis revealed by supraclavicular lymphadenopathy: a case report and literature review
Conclusion: testicular cancer in undescended testicles should not be ignored. Only early diagnosis and lower of testis in scrotumprevent such clinical forms. (Source: BMC Research Notes)
Source: BMC Research Notes - April 26, 2013 Category: Research Authors: Mohammed TaziOmar RiyachMustapha AhsainiYouness AhallalAbdelhak KhalloukMohammed El FassiMoulay Farih Source Type: research

Effect of the timing of orchiectomy on survival in patients with metastatic germ cell tumors of testis.
CONCLUSIONS: In case of severe symptoms of disease, which require an immediate start of CT, performing OE simultaneously with other surgeries after completion of induction CT was associated with better OS, when compared with performing OE during induction CT. PMID: 23628310 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - April 26, 2013 Category: Urology & Nephrology Authors: Fedyanin M, Tryakin A, Bulanov A, Fainshtein I, Zakharova T, Matveev V, Garin A, Tjulandin S Tags: Urol Oncol Source Type: research

Clinical features, presentation, and tolerance of platinum‐based chemotherapy in germ cell tumor patients 50 years of age and older
CONCLUSIONSMen aged ≥ 50 years comprise less than 10% of GCT diagnoses and have distinct clinical and histological characteristics as compared with younger patients. Although complications from chemotherapy occur frequently in older men, prognosis remains excellent when risk‐directed treatment is administered with curative intent. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - April 19, 2013 Category: Cancer & Oncology Authors: Darren R. Feldman, Martin H. Voss, Erin P. Jacobsen, Xiaoyu Jia, J. Andres Suarez, Stefan Turkula, Joel Sheinfeld, George J. Bosl, Robert J. Motzer, Sujata Patil Tags: Original Article Source Type: research

Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview
Abstract Testicular germ cell tumors (TGCTs), the most common malignancy in males between 15 and 34 years of age and the most frequent cause of death from solid tumors in this age group. TGCTs can be subdivided into seminoma and non‐seminoma germ cell tumors (NSGCTs), including embryonal cell carcinoma, choriocarcinoma, yolk sac tumor, and teratoma. Seminomas and NSGCTs do not only present distinctive clinical features, but they also show significant differences as far as therapy and prognosis are concerned. Seminomas are highly sensitive to both radiation and chemotherapy, with a good prognosis, non‐seminomas are sens...
Source: Journal of Cellular Physiology - April 18, 2013 Category: Cytology Authors: Paolo Chieffi, Sergio Chieffi Tags: Mini‐Review Source Type: research

Treatment of testicular intraepithelial neoplasia (intratubular germ cell neoplasia unspecified) with local radiotherapy or with platinum-based chemotherapy: A survey of the German Testicular Cancer Study Group
Conclusions Local radiotherapy is highly efficacious in curing TIN. Chemotherapy is significantly less effective and the cure rates are dose-dependent. Though hypogonadism occurs in one-third of patients, radiotherapy with 20 Gy remains the standard management of TIN. (Source: Annals of Oncology)
Source: Annals of Oncology - April 18, 2013 Category: Cancer & Oncology Authors: Dieckmann, K.- P., Wilken, S., Loy, V., Matthies, C., Kleinschmidt, K., Bedke, J., Martinschek, A., Souchon, R., Pichlmeier, U., Kliesch, S. Tags: urogenital tumors Source Type: research

Novel gene mutation identified that predisposes to testicular cancer
Researchers at the University Medical Center (UMC) Utrecht, the Netherlands, have identified a novel gene mutation that predisposes to seminoma, the most common form of testicular cancer in young men. (Source: Pharmacy Europe)
Source: Pharmacy Europe - April 12, 2013 Category: Drugs & Pharmacology Source Type: news

Monitoring of seminoma patients with serum markers
(Source: Cancer)
Source: Cancer - April 12, 2013 Category: Cancer & Oncology Authors: Kristina Hotakainen, Anna Lempiäinen, Ulf‐Håkan Stenman Tags: Correspondence Source Type: research

Reply to monitoring of seminoma patients with serum markers
(Source: Cancer)
Source: Cancer - April 12, 2013 Category: Cancer & Oncology Authors: Danny Vesprini, Padraig Warde, Peter Chung Tags: Correspondence Source Type: research

Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas
by Sander G. Basten, Erica E. Davis, Ad J. M. Gillis, Ellen van Rooijen, Hans Stoop, Nikolina Babala, Ive Logister, Zachary G. Heath, Trudy N. Jonges, Nicholas Katsanis, Emile E. Voest, Freek J. van Eeden, Rene H. Medema, René F. Ketting, Stefan Schulte-Merker, Leendert H. J. Looijenga, Rachel H. Giles Seminoma is a subclass of human testicular germ cell tumors (TGCT), the most frequently observed cancer in young men with a rising incidence. Here we describe the identification of a novel gene predisposing specifically to seminoma formation in a vertebrate model organism. Zebrafish carrying a heterozygous nonsense mutatio...
Source: PLoS Genetics - April 11, 2013 Category: Genetics & Stem Cells Authors: Sander G. Basten et al. Source Type: research

Anti-Ma-associated encephalitis due to dysgerminoma in a woman with Swyer syndrome
We report a case of anti-Ma–associated PLE/diencephalitis due to dysgerminoma in a woman with gonadal dysgenesis, or Swyer syndrome. (Source: Neurology)
Source: Neurology - April 8, 2013 Category: Neurology Authors: Al-Thubaiti, I., Al-Hayek, K., Binfalah, M. Tags: Autoimmune diseases, Paraneoplastic syndrome CLINICAL/SCIENTIFIC NOTES Source Type: research

Oncological outcomes in patients with stage I testicular seminoma and nonseminoma: pathological risk factors for relapse and feasibility of surveillance after orchiectomy
Conclusion: In both men with stage I seminoma and nonseminoma, surveillance after orchiectomy is afeasible option. However, disease extension through tunica albuginea might be a factorassociated with disease relapse in patients with organ-confined seminoma, and those withstage I nonseminoma showing lymphovascular invasion may possibly be at high risk fordisease relapse. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 8, 2013 Category: Pathology Authors: Kazuhiro KobayashiToshihiro SaitoYasuo KitamuraTomohiro NobushitaTakashi KawasakiNoboru HaraKota Takahashi Source Type: research

Excellent long-term disease control with modern radiotherapy techniques for stage I testicular seminoma-The Mayo Clinic experience.
CONCLUSIONS: This series confirms an excellent outcome in patients with stage I testicular seminoma treated with RT. Relapse after adjuvant RT is very uncommon, but late morbidity associated with RT may occur. PMID: 23490907 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - March 11, 2013 Category: Urology & Nephrology Authors: Hallemeier CL, Choo R, Davis BJ, Leibovich BC, Costello BA, Pisansky TM Tags: Urol Oncol Source Type: research

Psychological needs when diagnosed with testicular cancer: findings from a population‐based study with long‐term follow‐up
Conclusions The vast majority of Swedish testicular cancer survivors reported that they experienced a crisis because of their cancer diagnosis. Moreover, regardless of stage of disease, most men reported a need for psychological support at the time of diagnosis and treatment that was not satisfactorily met by the healthcare provision. (Source: BJU International)
Source: BJU International - March 7, 2013 Category: Urology & Nephrology Authors: Johanna Skoogh, Gunnar Steineck, Boo Johansson, Ulrica Wilderäng, Ulrika Stierner, Tags: Urological Oncology Source Type: research

Sperm DNA fragmentation in men with malignancy
Conclusion(s): In our study population there was no difference in sperm DFI between men undergoing prophylactic semen cryopreservation and men presenting for sperm donation. Sperm DFI assessment has limited utility in the routine evaluation of men presenting for semen cryopreservation. (Source: Fertility and Sterility)
Source: Fertility and Sterility - March 7, 2013 Category: Reproduction Medicine Authors: Simon McDowell, Keith Harrison, Ben Kroon, Emily Ford, Anusch Yazdani Tags: Andrology Source Type: research

[In process citation].
CONCLUSION: The majority of renal tumors represent primary neoplasm; in patients with extra-renal tumors we must consider the possibility of a metastatic disease. PMID: 23522318 [PubMed - in process] (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 1, 2013 Category: Surgery Authors: Castelán-Maldonado EE, Peña-Ruelas CI, Ignacio-Morales CV, Romero-Martínez SA, Sánchez-Arbea PC Tags: Cir Cir Source Type: research

Disappearance of a major thrombus in the brachiocephalic vein without anticoagulant therapy in a patient with seminoma: A case report.
Abstract This is the first case report describing brachiocephalic vein thrombosis without compression by a metastatic tumour during chemotherapy for testicular cancer. According to previous reports of testicular cancer patients with a major thrombus, anticoagulant therapy was required to resolve all cases. However, in the present case, a major thrombus in the brachiocephalic vein disappeared without anticoagulant therapy. This 42-year-old man was diagnosed with testicular seminoma and multiple metastases to the para-aortic lymph nodes. After 3 cycles of cisplatin, etoposide and bleomycin (PEB) therapy, a major thro...
Source: Canadian Urological Association Journal - March 1, 2013 Category: Urology & Nephrology Authors: Hongo H, Ide H, Hoshino K, Yasumizu Y, Uchida Y, Masuda T Tags: Can Urol Assoc J Source Type: research