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Acute Massive Pulmonary Embolism With Hemodynamic Compromise Treated Successfully With Thrombolytic Therapy SelcukEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 78 year-old woman presented with a history of 15 days of dyspnea and tachypnea at rest. A distended right ventricle with free-wall hypokinesis and displacement of the interventricular septum toward the left ventricle were shown on echocardiography. The patient suddenly arrested. She underwent cardiac catheterization and selective pulmonary angiography for suspected pulmonary embolism while undergoing cardiopulmonary resuscitation. With the diagnosis of pulmonary embolism confirmed, recombinant tissue plasminogen activator was given immediately in the catheterization room. This case shows how pulmonary embolism can be dia...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Pala, S., Kahveci, G., Bozok, S. Tags: Articles Source Type: journals

What you should know about the 2008 American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th) on Antithrombotic and Thrombolytic TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this article is to help answer ten common clinical questions frequently faced by anticoagulation management services. Content Type Journal ArticleDOI 10.1007/s11239-009-0415-2Authors Scott Kaatz, Henry Ford Hospital Department of Medicine Detroit MI 48202 USA Journal Journal of Thrombosis and ThrombolysisOnline ISSN 1573-742XPrint ISSN 0929-5305 (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study [BRAIN]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results of this study indicate that KPS is able to identify patients at higher risk of HT and may allow use of physiologic imaging rather than time from onset of symptoms to guide treatment decision. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Kassner, A., Roberts, T.P.L., Moran, B., Silver, F.L., Mikulis, D.J. Tags: BRAIN Source Type: journals

Influence of antiplatelet pre-treatment on the risk of intracranial haemorrhage in acute ischaemic stroke after intravenous thrombolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pre-treatment with AP is associated with an increased risk of PH after intravenous thrombolysis in patients with acute ischaemic stroke. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: L. Dorado, M. Millán, N. Pérez de la Ossa, C. Guerrero, M. Gomis, E. López-Cancio, A. C. Ricciardi, A. Dávalos Source Type: journals

Impact on patient care: patient case through the continuum of careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hospitalized patients are at increased risk of venous thromboembolism and the Joint Commission has initiated practice measures to improve the rates of preventable events. The Joint Commission also initiated the National Patient Safety Goals for medication prescribing and administration, of which, goal 03.05.01 is specifically aimed at anticoagulation therapy. These measures and goals are consistent with the American College of Chest Physicians’ Consensus Guidelines on Antithrombotic and Thrombolytic Therapy. This narrative review uses a case-based approach that brings up practical clinical questio...
Source: Journal of Thrombosis and Thrombolysis - November 9, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

[Reflection and Reaction] Extending the time window for thrombolytic therapy—primum non tardareEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
More than 15 years ago, thrombolytic therapy for acute was shown to be safe and effective in a pivotal trial by the National Institute of Neurological Disorders and Stroke (NINDS). Subsequent analyses of the dataset confirmed benefit in all subgroups; that therapy was cost-effective; that haemorrhage was more likely in treated patients but benefit remained; and that benefits were sustained after 1 year. Initial misunderstanding of the data analysis method and criticism from naysayers delayed implementation of thrombolytic therapy for acute stroke. Despite these initial delays, the treatment is now approved globally and is ...
Source: Lancet Neurology - November 9, 2009 Category: Neurology Authors: Patrick D Lyden Tags: Reflection and Reaction Source Type: journals

Prehospital Triage "Immediately Successful" in Boosting Rates of Thrombolytic Therapy for StrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toronto researchers report that a citywide prehospital protocol raised their rates of thrombolytic treatment to among the highest in North America, underlining, they say, the critical importance of organized stroke care. Medscape Medical News (Source: Medscape Pulmonary Medicine Headlines)
Source: Medscape Pulmonary Medicine Headlines - November 6, 2009 Category: Respiratory Medicine Tags: Neurology & Neurosurgery Source Type: info

An embolus in the right atrium caught in the Chiari network and resistant to thrombolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Case report is presented, which describes a patient with thromboemboli trapped in the Chiari network within the right heart and resistant to thrombolysis. The right atrial masses were completely removed under cardiopulmonary bypass. Histological evaluation confirmed a mixed thromboemboli, with thrombus structures showing signs of organization and surrounded by a fibrous capsule. A heterozygous methylenetetrahydrofolate reductase gene polymorphism was found, and the plasma level of the plasminogen activator inhibitor type-1 (PAI-1) was 50% higher than the normal upper limit. In this presented case, t...
Source: Journal of Thrombosis and Thrombolysis - November 6, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Paul Coverdell National Acute Stroke Registry Surveillance - four states, 2005-2007.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report summarizes PCNASR data collected during 2005-2007 from Georgia, Illinois, Massachusetts, and North Carolina, the first states to have PCNASRs implemented in and led by state health departments. DESCRIPTION OF SYSTEM: PCNASR was established by CDC in 2001 to track and improve the quality of hospital-based acute stroke care. The prototype phase (2001-2004) registries were led by CDC-funded clinical investigators in academic and medical institutions, whereas the full implementation of the 2005-2007 statewide registries was led by CDC-funded state health departments. Health departments in each state recruit hospita...
Source: MMWR Surveill Summ - November 6, 2009 Category: Epidemiology Authors: George MG, Tong X, McGruder H, Yoon P, Rosamond W, Winquist A, Hinchey J, Wall HK, Pandey DK, Tags: MMWR Surveill Summ Source Type: journals

Prehospital triage "immediately successful" in boosting rates of thrombolytic therapy for strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toronto researchers report that a citywide prehospital protocol raised their rates of thrombolytic treatment to among the highest in North America, underlining, they say, the critical importance of organized stroke care. (Source: theHeart.org)
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info

[Thrombolytic therapy in cerebral infarction.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background. Intravenous thrombolysis has gained widespread acceptance during the last 10 years, and is the only specific treatment approved for cerebral infarction. Haukeland University hospital introduced thrombolysis in 1998. The aim of this paper is to summarize our experience with the first 100 patients who had stroke caused by middle cerebral artery (MCA) occlusion and were treated with thrombolysis. Materials and methods. Patients receiving intravenous thrombolytic treatment between 1998 and 2005 were prospectively included into our database. We registered demographic data, risk factors, time aspects, short and l...
Source: Tidsskrift for den Norske Laegeforening - November 5, 2009 Category: Journals (General) Authors: Varga V, Waje-Andreassen U, Næss H, Lundstadsveen MT, Thomassen L Tags: Tidsskr Nor Laegeforen Source Type: journals

Gender differences in patients with acute ST-elevation myocardial infarction complicated by cardiogenic shockEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In women, STEMI was more often complicated by cardiogenic shock when compared to men. However, the use of early reperfusion therapy did not differ between the sexes. Primary PCI was associated with the best outcome in female patients with STEMI complicated by cardiogenic shock and is therefore the therapy of choice. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00392-009-0080-7Authors Oliver Koeth, Herzzentrum Ludwigshafen Department of Cardiology Ludwigshafen GermanyRalf Zahn, Herzzentrum Ludwigshafen Department of Cardiology Ludwigshafen GermanyTobias Heer, Herzzentrum L...
Source: Clinical Research in Cardiology - October 24, 2009 Category: Cardiology Tags: Clinical Research in Cardiology Source Type: journals

Thrombolysis for Acute Ischemic Stroke.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the last decennium, thrombolytic therapy has changed the management of acute ischemic stroke. Randomized clinical studies have demonstrated that intravenous thrombolysis with tissue plasminogen activator improves functional outcomes. Recently the time window for intravenous thrombolysis has been extended from 3 to 4.5 hours after stroke onset, which will allow more stroke patients to benefit from this treatment. Currently several studies are investigating how to improve recanalization rates of thrombolytic therapy. In this review several aspects of intravenous and intra-arterial thrombolysis are discussed. PMID:...
Source: Current Topics in Medicinal Chemistry - October 22, 2009 Category: Chemistry Authors: Uyttenboogaart M, De Keyser J, Luijckx GJ Tags: Curr Top Med Chem Source Type: journals

Intervention May Benefit Trial-Ineligible Heart PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In patients with ST-elevation myocardial infarction who are usually excluded from randomized controlled trials, primary percutaneous coronary intervention is associated with a lower rate of in-hospital death than thrombolytic therapy, according to a study in the Oct. 15 issue of the American Journal of Cardiology. (Source: Modern Medicine)
Source: Modern Medicine - October 14, 2009 Category: Journals (General) Source Type: info

Primary Stroke Centers Use More Thrombolytic Therapy Than Other Hospitals, but Overall Numbers Still LowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new study using data from the National Inpatient Sample shows about 3% of ischemic stroke patients received tPA at primary stroke centers between 2004 and 2006. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 14, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Thrombolytic therapy in acute myocardial infarction: Third Irish Working Party ConsensusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory GuidelinesDOI 10.1007/BF03166907Authors A Brown on behalf of the Irish Thrombolysis Concenus GroupJ. Horgan, Beaumont Hospital Dublin 9M. Conway, St Luke’s Hospital KilkennyW. Fennell, Cork University Hospital IrelandH. McCann, Mater Hospital DublinB. Meaney, Limerick Regional Hospital IrelandM. O’Reilly, Waterford Regional Hospital IrelandP. Sullivan, Mallow General Hospital Ireland Journal Irish Journal of Medical ScienceOnline ISSN 1863-4362Print ISSN 0021-1265 Journal Volume Volume 169 Journal Issue Volume 169, Number 2 / April, 2000 (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - October 14, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

Utilization and outcome of thrombolytic therapy for acute stroke in PakistanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the utilization of thrombolytic therapy is low and complication rate is high. Interventions for training physicians are needed. Content Type Journal ArticleCategory Brief CommunicationDOI 10.1007/s10072-009-0159-yAuthors Mohammad Wasay, Aga Khan University Department of Neurology and Medicine Stadium Road Karachi 74800 PakistanHazim Barohi, Aga Khan University Department of Neurology and Medicine Stadium Road Karachi 74800 PakistanAbdul Malik, Liaquat National Hospital Department of Neurology Karachi PakistanAdnan Yousuf, Aga Khan University Department of Neurology and Medicine Stadium Road Karachi 748...
Source: Neurological Sciences - October 9, 2009 Category: Neurology Tags: Neurological Sciences Source Type: journals

Can RAP save your brain?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this issue of Blood, Suzuki and colleagues report that the bleeding complications associated with thrombolytic therapy after ischemic stroke might be counteracted by RAP, the receptor-associated protein that inhibits ischemia-induced LRP, a signaling receptor for t-PA. (Source: Blood)
Source: Blood - October 8, 2009 Category: Hematology Authors: Horrevoets, A. J. G. Tags: INSIDE BLOOD Source Type: journals

SIGN issues draft guidelines on management of VTE and indications for antithrombotics for consultationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: SIGN Area: News The Scottish Intercollegiate Guidelines Network (SIGN) has issued draft guidelines on the prevention, investigation and management of venous thromboembolism, and, indications and management of antithrombotics for consultation. The venous thromboembolism guideline identifies patient groups at risk of VTE, and describes the available methods of prophylaxis. Additionally, recommendations are made on treatment options for thrombosis in various anatomical regions, including choice of anticoagulant and duration of use. The antithrombotics guideline aims to provide recommendations on...
Source: NeLM - Cardiovascular Medicine - October 6, 2009 Category: Cardiology Source Type: organizations

Role of Endogenous Granulocyte-Macrophage Colony Stimulating Factor Following Stroke and Relationship to Neurological Outcome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a proinflammatory cytokine with neuroprotective and angiogenic properties demonstrated in animal models of cerebral ischemia but their role in human ischemic stroke is still unknown. Thus, our aim is to determine human GM-CSF plasma level in control subjects and stroke patients and its relationship to clinical outcome. Forty-three patients with middle cerebral artery occlusion who received thrombolytic therapy within the first three hours of stroke onset and nineteen healthy controls were included. Blood samples were drawn before tissue plasminogen activator ...
Source: Current Neurovascular Research - October 6, 2009 Category: Neurology Authors: Navarro M, Rosell A, Penalba A, Ribó M, Alvarez-Sabín J, Fernández-Cadenas I, Montaner J Tags: Curr Neurovasc Res Source Type: journals

Excellent response to thrombolysis following prolonged basilar artery occlusion with extensive ischemic changes on MRIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mortality rates following acute basilar artery (BA) occlusion range between 50 and 95% . Recanalization of the BA with intra-arterial (IA) thrombolytic therapy has been shown to improve outcomes, particularly in selected patients treated within 24h of symptom onset . A number of features have been associated with poor outcome, including coma, tetraplegia and neuroimaging evidence of brainstem ischemia . We recently treated a patient who made an excellent recovery, despite the presence of all these prognostic features. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Glen Jickling, James Scozzafava, Muhammad S. Hussain, Tom Yeo, Ken S. Butcher Tags: Letter to the Editor Source Type: journals

Do women benefit more from systemic thrombolysis in acute ischemic stroke? A Serbian experience with thrombolysis in ischemic stroke (SETIS) studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There were no sex differences in functional outcome at 90 days after the stroke among patients treated with IV rtPA. This finding might confirm that thrombolytic therapy nullifies usual sex differences in stroke outcome and suggests that women with stroke may benefit more from rtPA treatment. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: D.R. Jovanović, Lj. Beslać-Bumbaširević, M. Budimkić, T. Pekmezović, M. Živković, V.S. Kostić, for the SETIS Investigation Group Tags: Original articles Source Type: journals

More Patients Arriving Within 2 Hours of Ischemic Stroke Are Receiving TPAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although no more stroke patients arrived within 2 hours of symptom onset between 2001 and 2004, more of those who did arrive received thrombolytic therapy, suggesting system improvements. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 2, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Should thrombolysis have a greater role in the management of pulmonary embolism?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary embolism (PE) continues to be associated with significant mortality despite advances in the diagnostic techniques available for its detection. Anticoagulation remains standard treatment in PE although there is a consensus view that 'step-up' to thrombolytic therapy in addition to anticoagulation is indicated in those patients who are systemically shocked at presentation--a group defined as having suffered 'massive pulmonary embolism'. Considerable research has been directed at attempting to identify further groups of patients with PE who are at high risk of morbidity and mortality--notably those who are label...
Source: Clinical Medicine - October 1, 2009 Category: Journals (General) Authors: Jenkins PO, Sultanzadeh J, Bhagwat M, Jenkins PF Tags: Clin Med Source Type: journals

Hunting for the “Sweet Spot” in P2Y12 Receptor Blockade⁎Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The addition of the P2Y12 antagonist clopidogrel to aspirin reduces ischemic events in unstable angina/non–ST-segment elevation myocardial infarction treated with medical therapy, percutaneous coronary intervention (PCI), or coronary artery bypass grafting (), in ST-segment elevation myocardial infarction (STEMI) treated with thrombolytic therapy (), and in elective PCI (). Dual antiplatelet therapy also reduces major adverse cardiovascular events and stent thrombosis after PCI compared with aspirin alone or the combination of aspirin and warfarin (). However, there are significant limitations of clopidogrel therapy. Clo...
Source: Journal of the American College of Cardiology - September 30, 2009 Category: Cardiology Authors: Daniel I. Simon, Sahil A. Parikh Tags: Acute MI and Antiplatelet Therapy: Editorial Comment Source Type: journals

Treatment of massive pulmonary embolism utilizing a multidisciplinary approach: a case study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Massive pulmonary embolism (PE) is associated, historically, with a high mortality rate. Treatment options include systemic anticoagulation, catheter-directed thrombolytic therapy, surgical embolectomy, fragmentation techniques, and catheter embolectomy. Extracorporeal membrane oxygenation (ECMO) repeatedly has demonstrated effectiveness in providing cardiopulmonary support for the patient with a massive PE too unstable to undergo thrombolysis or embolectomy. The present case study describes a morbidly obese patient, status post gastric bypass surgery, who presented with PE, and acute respiratory and cardiac failure. A...
Source: Perfusion - September 29, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Griffith KE, Haft J, Jenkins E Tags: Perfusion Source Type: journals

Magnetic Resonance Imaging for Monitoring the Efficacy of Thrombolytic Therapy in Subacute Pulmonary Artery EmbolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 67-year-old woman complained of recurrent episodes of dyspnea for 9 months with increasing intensity over the previous 10 days, culminating in resting dyspnea. Cardiovascular magnetic resonance (CMR) imaging revealed right ventricular enlargement with dyskinesia of the mid right ventricular free wall (McConnell sign, white arrows in D). CMR pulmonary angiography identified multiple pulmonary emboli with 2 thrombi lodging in the upper and lower lobe pulmonary branches (A and D). (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - September 23, 2009 Category: Cardiology Authors: Cosima Jahnke, Jan Kaufmann, Barbara Stauber, Stephan Goetze, Eckart Fleck, Ingo Paetsch Tags: IMAGES IN CARDIOLOGY Source Type: journals

Management of Acute Superior Mesenteric Artery Occlusion by Thrombolytic TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Case Rep Gastroenterol 2009;3:300-305 (DOI:10.1159/000239293) (Source: Karger Publishers)
Source: Karger Publishers - September 21, 2009 Category: Cancer & Oncology Source Type: journals

Multiorgan paradoxical embolism consequent to acute pulmonary thromboembolism with patent foramen ovale: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 79 years old woman admitted to hospital because of dyspnea and lower left limb pain. CT scan revealed multiple thrombi to kidney, lower limb and superior mesenteric artery during acute pulmonary embolism. Echocardiogram documented a patent foramen ovale with a right-to-left shunt. The patient was treated with thrombolytic therapy and heparin with progressive improvement of symptoms and resolution of pulmonary embolism and peripheral thrombosis. Patent foramen ovale closure was not performed because a life-long anticoagulation therapy was necessary, a tunnel-type patent foramen ovale may increases diff...
Source: Cases Journal - September 16, 2009 Category: Journals (General) Source Type: journals

The Alberta Stroke Program Early CT Score in clinical practice: what have we learned?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The introduction of brain imaging with computed tomography revolutionised the treatment of patients with acute ischaemic stroke. With the visual differentiation of haemorrhagic stroke from ischaemic stroke, thrombolytic therapy became feasible. The Alberta Stroke Program Early CT Score was devised to quantify the extent of early ischaemic changes in the middle cerebral artery territory on noncontrast computed tomography. With its systematic approach, the score is simple and reliable. However, the assessment of early ischaemic changes and Alberta Stroke Program Early CT scoring require training. The Alberta Stroke Program E...
Source: International Journal of Stroke - September 15, 2009 Category: Neurology Authors: V. Puetz, I. Dzialowski, M. D. Hill, A. M. Demchuk Tags: Topical review Source Type: journals

Thrombolytic therapy for strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapy , September 2009, Vol. 6, No. 5, Pages 733-745. (Source: Future Medicine: Therapy)
Source: Future Medicine: Therapy - September 14, 2009 Category: Internal Medicine Tags: article Source Type: journals

Identification of Unexpected Nonatherosclerotic Cardiovascular Disease With Coronary CT AngiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Approximately 1% of patients undergoing MDCT angiography for suspicion of CAD proved to have otherwise unsuspected, but clinically relevant, cardiovascular abnormalities unrelated to coronary atherosclerosis. Almost one-third of these patients had cardiovascular diseases with major clinical implications for subsequent therapy. These findings underscore the value of MDCT angiography and the importance of careful assessment of scans for the recognition of a variety of cardiovascular abnormalities. (Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - September 13, 2009 Category: Radiology Authors: Knickelbine, T., Lesser, J. R., Haas, T. S., Brandenburg, E. R., Gleason-Han, B. K., Flygenring, B., Longe, T. F., Schwartz, R. S., Maron, B. J. Tags: Original Research Source Type: journals

Intravenous Tissue Plasminogen Activator in Patients With Cocaine-Associated Acute Ischemic Stroke.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Thrombolytic therapy for CIS appears to be safe in this small study. Further research is needed to more definitively assess safety and efficacy of tissue plasminogen activator for CIS. PMID: 19745181 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - September 9, 2009 Category: Neurology Authors: Martin-Schild S, Albright KC, Misra V, Philip M, Barreto AD, Hallevi H, Grotta JC, Savitz SI Tags: Stroke Source Type: journals

Sub-analysis: Baseline antiplatelet therapy increases haemorrhage risk after thrombolytic therapy for ischaemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Reuters Health News Area: News According to sub-analysis of the Stroke-Acute Ischemic NXY Treatment [SAINT] I and II Trials cohort studies, baseline antiplatelet therapy is associated with an increased risk of intracerebral haemorrhage after thrombolytic therapy for ischaemic stroke. The investigators examined patients (n=965; mean age, 68 years, 57% male; 92% Caucasian) with acute ischaemic stroke who were treated with intravenous tissue plasminogen activator within 3 hours of symptom onset and were enrolled in the placebo arms of the SAINT studies. Early CT changes were graded using the Alb...
Source: NeLM - News - September 7, 2009 Category: Drugs & Pharmacology Source Type: organizations

Baseline Antiplatelet Therapy Increases Hemorrhage Risk After Stroke TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Baseline antiplatelet therapy is associated with an increased risk of intracerebral hemorrhage after thrombolytic therapy for ischemic stroke, according to a report in the September Stroke. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 4, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Massive Pulmonary Embolism: Percutaneous Emergency Treatment Using an Aspirex Thrombectomy CatheterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Massive pulmonary embolism (PE) is a life-threatening condition with a high early mortality rate caused by acute right ventricular failure and cardiogenic shock. A 51-year-old woman with a massive PE and contraindication for thrombolytic therapy was treated with percutaneous mechanical thrombectomy using an Aspirex 11F catheter (Straub Medical AG, Wangs, Switzerland). The procedure was successfully performed and showed a good immediate angiographic result. The patient made a full recovery from the acute episode and was discharged on heparin treatment. Our case report indicates that in patients with ...
Source: CardioVascular and Interventional Radiology - September 3, 2009 Category: Radiology Tags: CardioVascular and Interventional Radiology Source Type: journals

Primary Angioplasty Bests Thrombolysis in Very Elderly AMI Patients: TRIANAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Very elderly patients with acute MI fare better when treated with primary angioplasty than with thrombolytic therapy, Spanish researchers say. Heartwire (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 1, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Safe and Effective Intravenous Thrombolysis for Acute Ischemic Stroke Caused by Left Atrial MyxomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a young man who presented with syncope and a dense stroke developing as a complication of atrial myxoma, followed by a remarkable recovery after treatment with intravenous recombinant tissue plasminogen activator and urgent cardiac surgery. Contrary to some expert opinion, systemic thrombolytic therapy may be safely and effectively used to treat acute ischemic strokes from atrial myxoma. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2009 Category: Neurology Authors: Christian D. Nagy, Michael Levy, Thomas J. Mulhearn, Maryam Shapland, Henry Sun, David D. Yuh, Dickson Cheung, Nisha Chandra-Strobos Tags: Case Reports Source Type: journals

The MERCI retrieval system for the management of acute ischaemic stroke--the NNI Singapore experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Re-canalisation rates using the Merci Retrieval System was comparable to the multi-Merci trial. Haemorrhagic complications and safety were also found to be satisfactory. Importantly, treatment success with eventual good clinical outcome hinges strongly on the ability of the device to achieve complete re-canalisation. PMID: 19816632 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)
Source: Annals of the Academy of Medicine, Singapore - August 31, 2009 Category: Journals (General) Authors: Lee W, Sitoh YY, Lim CC, Lim WE, Hui FK Tags: Ann Acad Med Singapore Source Type: journals

Primary angioplasty bests thrombolysis in very elderly AMI patients: TRIANAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Very elderly patients with acute MI fare better when treated with primary angioplasty than with thrombolytic therapy, Spanish researchers say. (Source: theHeart.org)
Source: theHeart.org - August 31, 2009 Category: Cardiology Source Type: info

MRI predicts hemorrhage risk in acute strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using magnetic resonance imaging to measure blood–brain barrier disruption may predict the risk for hemorrhagic transformation after thrombolytic therapy, a Canadian team has shown. (Source: MedWire News - Stroke)
Source: MedWire News - Stroke - August 14, 2009 Category: Neurology Source Type: news

Geography, Structure, and Evolution of Diffusion and Perfusion Lesions in Diffusion and Perfusion Imaging Evaluation For Understanding Stroke Evolution (DEFUSE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Before thrombolytic therapy in the 3- to 6-hour time window, Type 2 geography is predominant and is associated with DWI reversal. After thrombolysis, both Type 2 geography and multiple lesion structure are associated with reperfusion. PMID: 19679845 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - August 12, 2009 Category: Neurology Authors: Olivot JM, Mlynash M, Thijs VN, Purushotham A, Kemp S, Lansberg MG, Wechsler L, Gold GE, Bammer R, Marks MP, Albers GW Tags: Stroke Source Type: journals

Acute lower limb ischemia in a patient with aortic thrombus and essential thrombocytosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aortic thrombus is rare in patients with essential thrombocytosis (ET), so the optimal treatment remains undefined. A 45-year-old man with history of ET, under chronic treatment with aspirin, presented to the emergency department complaining of acute onset in both the legs and abdominal pain. Physical examination revealed that both dorsalis pedis pulses were not palpable with cold and pale feet. His abdomen was soft and nondistended. The platelet count was 436 x 10(9)/L. The thoraco-abdominal computerized tomographic scanning revealed normal aortic diameter with supraceliac and infrarenal nonoccluding thrombus and infa...
Source: International Journal of Hematology - August 10, 2009 Category: Hematology Authors: Morata Barrado PC, Blanco Cañibano E, García Fresnillo B, Guerra Requena M Tags: Int J Hematol Source Type: journals

Invited Article: Searching for oracles?: Blood biomarkers in acute strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Emerging data suggest that a wide array of measurable biomarkers in blood may provide a novel window into the pathophysiology of stroke. In this review, we survey the state of progress in the field. Three specific questions are assessed. Can biomarkers augment the clinical examination and powerful brain imaging tools to enhance the accuracy of the diagnostic process? Can biomarkers be used to help triage patients for thrombolytic therapy? Can biomarkers help predict patients who are most susceptible to malignant infarction? Many encouraging molecular candidates have been found that appear to match the known cascades of neu...
Source: Neurology - August 2, 2009 Category: Neurology Authors: Foerch, C., Montaner, J., Furie, K. L., Ning, M. M., Lo, E. H. Tags: SPECIAL ARTICLE Source Type: journals

Right ventricular function in ST elevation myocardial infarction: effect of reperfusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: RV function deteriorated in STEMI compared with healthy controls. Contrary to the expectation, RV dysfunction was observed in anterior STEMI, but not in non anterior MI. There was no difference in RV function between the two treatment modalities. PMID: 19640332 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - August 1, 2009 Category: Biomedical Science Authors: Karakurt O, Akdemir R Tags: Clin Invest Med Source Type: journals

Primary Stent in Occluded Femoropopliteal Bypass Graft in a Patient with Contraindications for Thrombolytic Therapy: Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00270-009-9656-xAuthors M. Rabellino, Hospital Hospiten Rambla Department of Endovascular Therapy General Franco 115 Santa Cruz de Tenerife 38001 SpainL. García-Nielsen, Hospital Hospiten Rambla Department of Interventional Cardiology General Franco 115 Santa Cruz de Tenerife 38001 SpainG. Gonzalez, Hospital Hospiten Rambla Department of Endovascular Therapy General Franco 115 Santa Cruz de Tenerife 38001 SpainS. Baldi, Hospital Hospiten Rambla Department of Endovascular Therapy General Franco 115 Santa Cruz de Tenerife 38001 SpainT. Zander, Hospita...
Source: CardioVascular and Interventional Radiology - July 31, 2009 Category: Radiology Tags: CardioVascular and Interventional Radiology Source Type: journals

Serum myeloperoxidase level predicts reperfusion in patients with myocardial infarction receiving thrombolytic therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Polymorphonuclear leukocytes play a central role in all stages of the atherothrombotic inflammatory process. The atherothrombotic activity of polymorphonuclear leukocytes is exerted by mediators such as myeloperoxidase (MPO). Although the role of MPO has been studied with respect to the development of adverse cardiac events in acute coronary syndromes (ACS), the association of this molecule with effectiveness of reperfusion in patients receiving thrombolysis is not yet known. The study population consisted of a total of 158 patients with acute coronary syndromes. Final diagnosis was ST-segment eleva...
Source: Heart and Vessels - July 24, 2009 Category: Cardiology Tags: Heart and Vessels Source Type: journals

Original article Acute pulmonary embolism registry in the Małopolska region – clinical courseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 1. In our registry mortality rate in patients with APE was 11%. 2. In about 30% of patients APE was under mask of acute coronary syndrome or syncope, 34% of patients had elevated troponin level, and 30% of patients had complication during hospitalisation. 3. In patients treated with thrombolytics mortality rate was 45%. 4. Reperfusion strategy (trombolysis or embolectomy) in the high risk group was used in only 41% of patients. 5. Elevated troponin level in normotensive patient was associated with 4-fold times higher risk of death. 6. New risk stratification according to the ESC guidelines 2008 correctly predi...
Source: Articles of Polish Heart Journal - TERMEDIA publishing house - July 17, 2009 Category: Cardiology Source Type: journals

Neuropsychological functioning in right hemisphere infarct patients—Does thrombolytic treatment matter?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background and aims: The effect of thrombolytic therapy on neuropsychological deficits following acute stroke has received only limited research attention. This preliminary study examines the influence of thrombolytic therapy on neuropsychological performance in right hemisphere infarct patients. Since visual abilities are known to be defective after right hemisphere damage, the present study concentrates on visuoconstructive abilities, visual search and reasoning, and visual neglect. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 17, 2009 Category: Neurology Authors: M. Laihosalo, J.E. Kettunen, A.-M. Koivisto, P. Dastidar, J. Ollikainen, M. Jehkonen Tags: Abstracts Source Type: journals

Starting point as an indicator of neglect in right hemisphere infarct patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background and aims: Visual neglect (VN) is a common defect after right hemisphere (RH) infarct, and RH patients have a tendency to begin visual scanning from the right side of a given stimulus. Our aim was to find out whether neglect, non-neglect and thrombolytic therapy patients with first-ever RH infarct differ in terms of their starting points in cancellation tasks. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 17, 2009 Category: Neurology Authors: J.E. Kettunen, M. Laihosalo, A.-M. Koivisto, P. Dastidar, J. Ollikainen, M. Jehkonen Tags: Abstracts Source Type: journals