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Blood transfusion therapy for 41 earthquake casualtiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Blood transfusion was an effective therapy for the earthquake casualties. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Zhongjun Li, Weidong Wang, Te Chen Tags: Submitted Papers Source Type: journals

Postop Anemia in High-CV-Risk Patients: No CV Gains From Fixed Hemoglobin Target in TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A randomized trial found no protection from in-hospital cardiovascular events with a strategy of blood transfusions to maintain hemoglobin above 10 g/dL, compared with a more conservative approach to transfusion therapy, in patients with CV disease or risk factors who underwent hip surgery. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 18, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Postop anemia in high-CV-risk patients: No CV gains from fixed hemoglobin target in trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A randomized trial found no protection from in-hospital cardiovascular events with a strategy of blood transfusions to maintain hemoglobin above 10 g/dL, compared with a more conservative approach to transfusion therapy, in patients with CV disease or risk factors who underwent hip surgery. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Successful management of fresh-frozen plasma transfusion therapy based upon clinical symptoms for total knee arthroplasty in a patient with severe factor V deficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Haemophilia)
Source: Haemophilia - November 11, 2009 Category: Hematology Authors: C. RIDEAU, E. GAERTNER, M. BLAY, C. TROJANI, P. TOULON Source Type: journals

Red blood cell transfusion in the intensive care setting: controversies amongst evidenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A anemia é um problema prevalente nas unidades de terapia intensiva. Ela surge nos primeiros dias e pode sustentar-se, ou agravar-se, durante a internação. A etiologia normalmente é multifatorial. A transfusão de hemácias é a intervenção mais comumente utilizada para combatê-la. Aproximadamente 12 milhões de unidades de sangue são utilizadas para transfusões nos Estados Unidos, sendo 25% a 30% dentro das terapias intensivas. A maior segurança com a diminuição das infecções provocadas por transfusões permitiu uma ampliação de indicações clínicas. No entanto, a terapia transfusional está associada a ...
Source: Revista Brasileira de Terapia Intensiva - November 6, 2009 Category: Intensive Care Source Type: journals

HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alloimmunization to minor red blood cell (RBC) antigens occurs commonly in sickle cell disease (SCD). Patients with alloimmunization demonstrate increased risk for new alloantibody formation with subsequent transfusion. Alloimmunization to human leukocyte antigens (HLA) can occur with RBC transfusion and may result in graft rejection during stem cell or organ transplantation. The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown.A cross-sectional study of HLA alloimmunization in SCD patients aged 3-21 years with a history of [ge]3 RBC transfusions was performed t...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Marianne E. McPherson, Alan R. Anderson, Marta-Inés Castillejo, Christopher D. Hillyer, Robert A. Bray, Howard M. Gebel, Cassandra D. Josephson Source Type: journals

Understanding iron overload: screening, monitoring, and caring for patients with transfusion-dependent anemias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients receiving recurring blood transfusions as supportive therapy to treat chronic anemias, such as myelodysplastic syndromes, thalassemia, and sickle-cell disease, are at risk of iron accumulation. The clinical consequences of iron overload are progressive liver damage, cardiac disease, and endocrine disorders, which can be fatal. Nurses have a vital role in the initial assessment and monitoring of patients undergoing transfusion therapy and their ongoing care. Iron levels may be managed effectively with iron chelation therapy, and treatment guidelines recommend initiation when serum ferritin levels reach more tha...
Source: Clinical Journal of Oncology Nursing - September 30, 2009 Category: Nursing Authors: Ault P, Jones K Tags: Clin J Oncol Nurs Source Type: journals

Consensus and controversies in platelet transfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the current developments and challenges in optimizing platelet transfusion therapy. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Neelam Marwaha, R.R. Sharma Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Red cell exchange employing phenotypically matched deglycerolized red blood cells to treat acute sickle cell crisis: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Red blood cell (RBC) transfusion in sickle cell patients, especially young recipients, is at high risk for multiple reasons. The high susceptibility to develop alloantibodies, together with haemolytic transfusion reactions that would impair future transfusion therapy imposes the choice of RBC concentrates respecting as much as possible, the patient’s phenotype . Furthermore ethnic difference between donors and RBC recipients is critical to heighten the possibility of alloimmunization against foreign antigens. Sickle cell crisis is a very severe painful condition resulting in tissue infarction of different organs (brain, ...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Cesare Perotti, Paola Isernia, Claudia Del Fante, Gianluca Viarengo, Laura Salvaneschi, Maurizio Marconi, Maria Antonietta Villa Tags: Letter to the Editor Source Type: journals

Granulocyte transfusion therapy in abdominal organ transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We observed temporal increases in ANC to levels above 1,000/[mu]l in 15/18 (83.3%) courses of GT. We observed a clinical response to infection in 5/12 (42%) patients, the remaining infected patients had no clinical response. Our results suggest that GT therapy in neutropenic solid organ transplant recipients can boost peripheral blood neutrophil counts. Additional studies areneeded to document an independent clinical benefit for GT in this patient population. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - September 14, 2009 Category: Hematology Authors: Nikhil R. Oak, Darrell J. Triulzi Source Type: journals

Red Bood Cell Transfusion Therapy and Iron Chelation in Patients With Myelodysplastic Syndromes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anemia is the most frequent peripheral cytopenia observed in myelodysplastic syndromes (MDS) and has been recognized among the most important factors affecting the outcome of patients with MDS. In patients who are not candidates for potentially curative approaches, therapeutic options for symptomatic anemia include red blood cell (RBC) transfusion and iron chelation, hematopoietic growth factors, immunosuppression, immune-modulatory drugs, and hypomethylating agents. In about 40% of patients, regular RBC transfusions are the only therapeutic option that can be offered. The onset of a regular transfusion requirement sig...
Source: Clinical Lymphoma and Myeloma - August 31, 2009 Category: Cancer & Oncology Authors: Malcovati L Tags: Clin Lymphoma Myeloma Source Type: journals

Prevalence of sickle cell disease in a northeastern region of the Democratic Republic of Congo: what impact on transfusion policy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transfusion therapy may save the lives of patients with sickle cell disease (SCD), but it is also associated with a high risk of transmission of infection. The aims of this study were to determine the prevalence of SCD in a northeastern region of the Democratic Republic of Congo (DRC), and to define ways in which the procedures involved in the security of transfusions should be improved. During a 3-month period in 2006/2007, 520 samples of umbilical cord blood were obtained through neonatal screening in five health centres in Kisangani. The samples were analysed using an isoelectric focusing technique. The estimated preval...
Source: Transfusion Medicine - August 26, 2009 Category: Hematology Authors: B. Agasa, K. Bosunga, A. Opara, K. Tshilumba, E. Dupont, F. Vertongen, F. Cotton, B. Gulbis Source Type: journals

Prevalence and specificities of red blood cell alloantibodies in transfused Ugandans with different diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The prevalence of RBC alloimmunization in transfused Ugandans was 6·1% and was associated with the number of donor exposures. This immunization rate is similar to that observed in transfused Caucasians despite differences in RBC antigen distributions. Patients with malaria were less likely to develop RBC alloantibodies. Alloantibodies were mainly against E and S antigens. We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 23, 2009 Category: Hematology Authors: B. Natukunda, H. Schonewille, L. van de Watering, A. Brand Source Type: journals

The role of religious leaders and faith organisations in haemoglobinopathies - a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Religious leaders and faith organisations have the potential to influence health education, health promotion and positive health outcomes amongst members of their faith community. They also provide potential access to at-risk populations for increasing awareness about SCD, encouraging health service utilization and ethnic blood donor drives. (Source: BMC Blood Disorders)
Source: BMC Blood Disorders - August 14, 2009 Category: Hematology Authors: Thelma Toni-UebariBaba Inusa Source Type: journals

Iron overload and toxicity: the hidden risk of multiple blood transfusionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Increased awareness of the risks of iron overload from chronic transfusion therapy should result in greater use of interventions such as iron chelation to reduce total body iron and the risk of long-term sequelae. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 2, 2009 Category: Hematology Authors: A. Shander, M. D. Cappellini, L. T. Goodnough Source Type: journals

Retrospective analysis of transfusion outcomes in pregnant patients at a tertiary obstetric centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: The decision to use red blood cell transfusion and/or blood products (fresh frozen plasma, platelets, cryoprecipitate) to manage obstetric hemorrhage or treat postpartum anemia is often made empirically by physicians. We performed a retrospective study to review transfusion outcomes in pregnant and postpartum patients at a large obstetric center.Methods: A retrospective, observational study was performed of obstetric in-patients who received red blood cell transfusion and/or blood products over a one-year period. Data abstracted included transfusion data, pre-transfusion hemoglobin (Hb) and lowest rec...
Source: International Journal of Obstetric Anesthesia - July 22, 2009 Category: Anesthesiology Authors: A.J. Butwick, P. Aleshi, M. Fontaine, E.T. Riley, L.T. Goodnough Tags: Original Articles Source Type: journals

Guidelines for Managing Conscientious Objection to Blood TransfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Parents sometimes deny their children blood transfusion because of their religious beliefs. The Japanese Joint Committee on the Refusal of Blood Transfusion on Religious Grounds asserts that the health and life of every child younger than 15 years should be guarded by the collective efforts of health, welfare, and advocacy institutions when a parent or guardian seeks to withhold transfusion therapy. Patients 18 years or older should receive treatment without transfusion after signing and submitting a “Certificate of Refusal Blood Transfusion and Exemption from Liability.” For a patient younger than 18 years, but 15 yea...
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Hitoshi Ohto, Yuji Yonemura, Junzo Takeda, Eiichi Inada, Ryoji Hanada, Satoshi Hayakawa, Takeshi Miyano, Katsunori Kai, Waichiro Iwashi, Kaori Muto, Fumikazu Asai Source Type: journals

Transfusion Therapy: Optimal Use of Blood Products.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 193Authors: Surgenor, Stephen D M.D. (Source: ASA Refresher Courses in Anesthesiology)
Source: ASA Refresher Courses in Anesthesiology - June 14, 2009 Category: Anesthesiology Tags: HTML PDF (272 K) Source Type: journals

Managing iron overload in patients with myelodysplastic syndromes with oral deferasirox therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with myelodysplastic syndromes (MDS) often require chronic RBC transfusions, which can lead to iron overload. Without adequate management, this may cause progressive damage to hepatic, endocrine, and cardiac organs, significantly affecting overall survival. Recent retrospective analyses have suggested that iron chelation provides a survival advantage in iron-overloaded patients with MDS who are given chelation therapy compared with those who are not. Nonetheless, it is evident that iron overload in many patients with MDS is not adequately managed. Clinical evaluation of the once-daily, oral iron chelator defer...
Source: The Oncologist - April 30, 2009 Category: Cancer & Oncology Authors: Jabbour E, Garcia-Manero G, Taher A, Kantarjian HM Tags: Oncologist Source Type: journals

Clinical features and molecular analysis in Thai patients with HbH diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We studied the α-globin gene abnormalities, the clinical features, hematologic values, growth assessment, transfusion therapy, and serum ferritin levels of patients with hemoglobin H (HbH) disease in southern Thailand. HbH disease in 83 of the 147 patients was the deletional type of HbH. The remaining 64 patients was the nondeletional type of HbH disease. All 83 patients with the deletional type were double heterozygotes of α0-thalassemia and α+-thalassemia. The Southeast Asian type of α0-thalassemia accounted for 98% of the Thai patients with HbH disease and the Thai type of α0-thalassemia made...
Source: Annals of Hematology - April 24, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals

Utilization of TCD screening for primary stroke prevention in children with sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Since the Stroke Prevention Trial in Sickle Cell Anemia, the rate of transcranial Doppler ultrasonography (TCD) screening in sickle cell disease (SCD) has increased sixfold within a large health care plan. Children living farther from a vascular laboratory are less likely to be screened. Increased availability of TCD screening could improve the utilization of this effective primary stroke prevention strategy. (Source: Neurology)
Source: Neurology - April 13, 2009 Category: Neurology Authors: Armstrong-Wells, J., Grimes, B., Sidney, S., Kronish, D., Shiboski, S. C., Adams, R. J., Fullerton, H. J. Tags: Childhood stroke, Stroke prevention, Ultrasound, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, Screening in epidemiology ARTICLES Source Type: journals

Transfusion Therapy in Postpartum HemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postpartum hemorrhage (PPH) is an obstetric emergency that can occur following vaginal or cesarean delivery. Rapid diagnosis of PPH using laboratory and clinical parameters is an important first step in its management. Traditional blood components, including packed red blood cells, platelets, plasma, and cryoprecipitate, should be used in patients with significant bleeding. Recent studies underline the utility of transfusing these components in defined ratios to prevent dilutional coagulopathy. Disseminated intravascular coagulation (DIC) should be considered in severely bleeding obstetric patients and should be treated ag...
Source: Seminars in Perinatology - April 1, 2009 Category: Perinatology & Neonatology Authors: Anand Padmanabhan, Joseph Schwartz, Steven L. Spitalnik Source Type: journals

Right patient, right blood, right care: safe transfusion practice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article examines the key principles and practicalities to be considered in day-to-day practice. Areas covered include legal obligations, appropriate handling of blood components, the different elements of the transfusion process, recognition and management of transfusion reactions and education. A key theme running throughout is the management of clinical risk. PMID: 19273993 [PubMed - as supplied by publisher] (Source: British Journal of Nursing)
Source: British Journal of Nursing - March 11, 2009 Category: Nursing Authors: Oldham J, Sinclair L, Hendry C Tags: Br J Nurs Source Type: journals

Duffy genotyping facilitates transfusion therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The Duffy (FY) blood group system is clinically significant in transfusion medicine because FY antibodies are involved in hemolytic transfusion reactions and hemolytic disease of the newborn. The Fya and Fyb antigens are encoded by the FY*A and FY*B alleles which are responsible for the Fy(a+b+), Fy(a+b−) and Fy(a−b+) phenotypes. The Fy(a−b−) phenotype is found in individuals homozygous for a silent FY*B allele, named FY*B ES , which is caused by a mutation in the promoter region of FY*B that result in the loss of FY expression in the erythroid linage. The aim of the present study was to e...
Source: Clinical and Experimental Medicine - February 19, 2009 Category: Research Tags: Clinical and Experimental Medicine Source Type: journals

Transfusion medicine and safety.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Advances in safety of blood transfusion in clinical practice principally relate to preventing transfusion-transmitted infections (TTI). Epidemiological studies of TTI have resulted in the development, standardization, and implementation of an expanding array of immunoassays employed worldwide in routine screening of blood donated by voluntary blood donors. Exclusion of infected blood and their donors has remarkably reduced the risk of transmitting HBV, HCV, HIV-1/2, and HTLV-I/II infections. Nucleic acid tests (NAT) using enzymatic amplification of viral gene sequences have augmented the risk reduction in "window perio...
Source: Biologicals : Journal of the International Association of Biological Standardization - February 19, 2009 Category: Biotechnology Authors: Dodd R, Kurt Roth W, Ashford P, Dax EM, Vyas G Tags: Biologicals Source Type: journals

Patient-specific component requirements: 'right blood, right patient, right time, right place'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although transfusion therapy may save the patient's life, it also carries the risk of severe complications and is therefore recommended only when all other forms of treatment have proved ineffective. The decision to transfuse should be preceeded by careful evaluation of the clinical condition of each individual patient and not be based exclusively on laboratory results (e.g. hemoglobin concentration). Whenever possible, only such components should be transfused, the lack of which is responsible for the disease symptoms. Most blood is separated into components prior to transfusion which offers several advantages: i) blood r...
Source: ISBT Science Series - February 13, 2009 Category: Hematology Authors: M. Letowska Tags: XIXth Regional Congress of the ISBT, Eastern Mediterranean & amp; Europe Source Type: journals

Proteomics and blood transfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transfusion medicine is a clinical discipline characterized by one of the most advanced quality management systems, which is structured so as to assure the production of blood components and raw materials, for biopharmaceutical fractionation, that are safe, efficient and effective. During the production, pathogen inactivation and storage processes there is the risk of changes in the integrity of blood components, especially at the protein level. These changes could be the cause of some of the negative effects of transfusion therapy. It is therefore a major challenge to identify significant alterations of these products, an...
Source: ISBT Science Series - February 13, 2009 Category: Hematology Authors: G. M. Liumbruno, G. M. D'Amici, L. Zolla, G. Grazzini Tags: XIXth Regional Congress of the ISBT, Eastern Mediterranean & amp; Europe Source Type: journals

Cocaine Abuse Complicating Acute Painful Episodes in Sickle Cell Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report clinical outcomes in three patients in which cocaine use preceded a sickle cell pain episode.Page: 87DOI: 10.1097/SMJ.0b013e318188b2abAuthors: Boulmay, Brian MD; Lottenberg, Richard MD (Source: Southern Medical Journal)
Source: Southern Medical Journal - January 6, 2009 Category: Journals (General) Tags: Abstract HTML PDF (90 K) Source Type: journals

Hepatitis B virus reactivation during combined therapy with deferiprone and desferioxamine in a hepatitis B surface antigen thalassemic carrier.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report we firstly describe a case of reactivation of hepatitis B virus (HBV) replication occurred in a patient affected by Thalassemia major which underwent a combined chelation therapy with desferioxamine (DFO) and deferiprone (DFP). Clinical symptom and increase in alanine aminotransferase (ALT) level were detected when the prescription of DFO (30 mg/kg) was increased from 3 to 5 days/week; a raise in HBV-DNA levels of greater than or equal to tenfold compared with baseline was thereafter detected. Diagnosis was troublesome because increasing ALT levels, first suggested toxicity to DFP administration. However, HB...
Source: International Journal of Hematology - December 25, 2008 Category: Hematology Authors: Ricchi P, Cinque P, Lanza Galeota A, Di Matola T, Ammirabile M, Prossomariti L Tags: Int J Hematol Source Type: journals

Does regular blood transfusion prevent progression of cerebrovascular lesions in children with sickle cell disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A retrospective study was conducted to assess changes in cerebrovascular lesions, as assessed by magnetic resonance (MR) imaging and angiography in 18 children with sickle cell disease (SCD) receiving optimised chronic transfusions for primary stroke prevention (abnormal transcranial Doppler flow, nine patients, median follow-up 14.3 months (range, 7.9–48.9)) or secondary stroke prevention (nine patients, median follow-up 59.6 months (range, 11.0–127.9)). An experienced neuroradiologist blinded to patient data reviewed the 41 MR scans (median/patient, three (2–4)). Standard scores we...
Source: Annals of Hematology - December 24, 2008 Category: Hematology Tags: Annals of Hematology Source Type: journals

Blood Transfusion Therapy Data CardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Administration of Blood Components (ISBN: 978-3-8055-9107-2) (Source: Karger Publishers)
Source: Karger Publishers - December 18, 2008 Category: Databases & Libraries Source Type: info

Blood Transfusion Therapy: A Physician's HandbookEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
9th edition (ISBN: 978-3-8055-9105-8) (Source: Karger Publishers)
Source: Karger Publishers - December 18, 2008 Category: Databases & Libraries Source Type: info

ASH: Stroke in Sickle Cell Children Reduced by ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO (MedPage Today) -- Screening by transcranial Doppler ultrasound, followed by transfusion therapy, almost eliminated the risk of a stroke among children with sickle cell disease, a researcher said here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - December 8, 2008 Category: Cardiology Source Type: news

Granulocyte transfusion therapy: a new era?.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 1DOI: 10.1097/MOH.0b013e32831d7953Authors: Dale, David C a; Price, Thomas H b (Source: Current Opinion in Hematology)
Source: Current Opinion in Hematology - December 5, 2008 Category: Hematology Tags: HTML PDF (64 K) Source Type: journals

Effect of transfusion therapy on cerebral vasculopathy in children with sickle-cell anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This retrospective study assessed the long-term effect of transfusional exchange therapy on MRA/MRI abnormalities in 24 homozygous sickle-cell anemia (HbSS) children presenting with abnormal brain MRA. The median time elapsed from baseline to last available MRA was 29 months. Follow-up MRAs showed improvement, stabilization or worsening of cerebrovascular lesions in 11, 6 and 7 patients respectively. Complete normalization of MRA was observed in 6 patients within a mean time of 1.4 years, but stenosis recurred at the same location in the 4 patients in whom transfusion therapy was discontinued. Baseline severe stenosis/...
Source: Haematologica - December 4, 2008 Category: Hematology Authors: Bader-Meunier B, Verlhac S, Elmaleh-Bergès M, Ithier G, Sellami F, Faid S, Missud F, Ducrocq R, Alberti C, Zaccaria I, Baruchel A, Benkerrou M Tags: Haematologica Source Type: journals

Successful use of recombinant activated factor VII for postoperative associated haemorrhage: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Published clinical experiences for the use of rFVIIa in trauma patients are limited to small series and case reports. However, in trauma patients, administration of rFVIIa appears to be effective in addition to prompt surgical intervention as an adjunctive haemostatic measure to control life threatening bleeding in appropriately selected patients. (Source: BioMed Central)
Source: BioMed Central - November 29, 2008 Category: Journals (General) Authors: Konstantinos Vlachos, Fotis Archontovasilis, Artemisia Papadima, Dimitrios Maragiannis, Stavros Aloizos, Emmanuel Lagoudianakis, Ioannis G Dalianoudis, Nikolaos Koronakis, John Chrysikos, Spyros Zaravinos and Andreas Manouras Source Type: journals

Pediatric and newborn strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Opinion statement In children, arterial ischemic stroke is more common than hemorrhage. The clinical presentation differs according to age, stroke type, and location. Seizures are more common with ischemia in children, especially in newborns. The presentation of pediatric ischemic stroke is more complex than in adults, so the clinical phenotype of ischemic stroke is modified. Risk factors for ischemic and hemorrhagic stroke include congenital heart disease, blood disorders, vasculopathies, infections (both current and preceding the stroke), and vascular malformations, but often no discernible etiology is det...
Source: Current Treatment Options in Neurology - November 25, 2008 Category: Neurology Tags: Current Treatment Options in Neurology Source Type: journals

Efficacy of recombinant activated Factor VII in patients with massive uncontrolled bleeding: a retrospective observational analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study suggests that rFVIIa may play a role in patients with massive uncontrolled blood loss by reducing the amount of RBC and FFP transfusions and by improving the coagulation variables. PMID: 19040498 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 25, 2008 Category: Hematology Authors: Berkhof FF, Eikenboom JC Tags: Transfusion Source Type: journals

The Sickle Cell Sabbath: a community program increases first-time blood donors in the African American faith community.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: An educational program that engages the African American faith community more than quadruples the rate of expected first-time blood donors when compared to the general community over this 4-year period. PMID: 19040492 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 25, 2008 Category: Hematology Authors: Price CL, Johnson MT, Lindsay T, Dalton D, Debaun MR Tags: Transfusion Source Type: journals

Treatment and Prevention of Neonatal AnemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Because red blood cell (RBC) transfusion therapy remains the primary treatment of anemia encountered in early life, the basis for RBC transfusion in the treatment of symptomatic anemia is discussed in this review along with several important aspects of neonatal blood banking practices. Nontransfusion approaches to the prevention and treatment of neonatal anemia also are described. Finally, this review covers the controversy surrounding whether neonatal RBC transfusion therapy should be restrictive or liberal. The evaluation and treatment of uncommon and rare acquired and genetic causes of anemia in newborn infants are beyo...
Source: NeoReviews recent issues - October 31, 2008 Category: Pediatrics Authors: Widness, J. A. Tags: Fetus and Newborn Infant, Disorders of Blood/Neoplasms Articles Source Type: info

Transfusion Related Acute Lung Injury presenting with acute dyspnoea: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The diagnosis of transfusion-related acute lung injury relies on excluding other causes of acute pulmonary edema following transfusion, such as sepsis, volume overload, and cardiogenic pulmonary edema. All plasma containing blood products have been implicated in transfusion-related acute lung injury, with the majority being linked to whole blood, packed red blood cells, platelets, and fresh-frozen plasma. The pathogenesis of transfusion-related acute lung injury may be explained by a "two-hit" hypothesis, involving priming of the inflammatory machinery and then activation of this primed mechanism. Treatment is ...
Source: BioMed Central - October 28, 2008 Category: Journals (General) Authors: Altaf Gauhar Haji, Shekhar Sharma, D K Vijaykumar and Jerry Paul Source Type: journals

Transfusion Therapy: Optimal Use of Blood Products.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 193Authors: Surgenor, Stephen D M.D. (Source: ASA Refresher Courses in Anesthesiology)
Source: ASA Refresher Courses in Anesthesiology - October 10, 2008 Category: Anesthesiology Tags: HTML PDF (272 K) Source Type: journals

Designing Property Specifications to Improve the Safety of the Blood Transfusion Process.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Computer scientists use a number of well-established techniques that have the potential to improve the safety of patient care processes. One is the formal definition of a process; the other is the formal definition of the properties of a process. Even highly regulated processes, such as laboratory specimen acquisition and transfusion therapy, use guidelines that may be vague, misunderstood, and hence erratically implemented. Examining processes in a systematic way has led us to appreciate the potential variability in routine health care practice and the impact of this variability on patient safety in the clinical setti...
Source: Transfusion Medicine Reviews - October 1, 2008 Category: Hematology Authors: Henneman EA, Cobleigh R, Avrunin GS, Clarke LA, Osterweil LJ, Henneman PL Tags: Transfus Med Rev Source Type: journals

Intraoperative Platelet and Plasma Improves Survival in Patients Operated for a rAAA: A Follow-up Evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Early administration of platelets and plasma, together with red blood cells maintained reduced mortality in patients operated for rAAAin a 18 month period. PMID: 18538595 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - June 4, 2008 Category: Surgery Authors: Johansson PI, Swiatek F, Jørgensen L, Jensen LP, Secher NH Tags: Eur J Vasc Endovasc Surg Source Type: journals

Treatment of cancer-related anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anemia with consequent tissue hypoxia is common problem in cancer patients. Developed via various patophysiological mechanisms, it has deleterious effect on quality of life and survival of patients with cancer. Recognition of symptoms and timely initiation of treatment improve patients' quality of life, as well as efficacy of oncological treatment. Red blood cells transfusions are well known and efficient way of anemia correction. They are "golden standard" in treatment of cancer-related anemia today, and are unavoidable in almost all patients with hemoglobin concentration below 80 g/L. Newest therapy guidelines in dev...
Source: Collegium Antropologicum - June 1, 2008 Category: Epidemiology Authors: Badzek S, Curić Z, Krajina Z, Plestina S, Golubić-Cepulić B, Radman I Tags: Coll Antropol Source Type: journals

Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the current standard of care in monitoring iron overload and ... (Source: Transfusion)
Source: Transfusion - May 29, 2008 Category: Hematology Tags: article Source Type: journals

Transfusion therapy for autoimmune hemolytic anemia patients: a laboratory perspective.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients presenting with autoimmune hemolytic anemias create inherent challenges to those tasked with providing compatible blood for transfusion therapy. These patients have developed autoantibodies against their own red cell surface antigens. Because these antigens are usually high-incidence, these patients will typically demonstrate panagglutination when their serum is exposed to most commercially procured screening red blood cells. This makes the identification of clinically significant alloantibodies difficult for laboratory personnel. Transfusion history, patient phenotype availability, and previous antibody recor...
Source: Clinical Laboratory Science : Journal of the American Society for Medical Technology - May 16, 2008 Category: Laboratory Medicine Authors: Drouillard DD Tags: Clin Lab Sci Source Type: journals

Distribution of the FY*BES and RHCE*ce(733C>G) alleles in an Argentinean population: implications for transfusion medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Taken together, the results suggest that admixture events between African slaves and European immigrants at the beginning of the 20th century made the physical characteristics of black Africans to be invisible nowadays. Considering that it was a recent historical event, the FY*BES and RHCE*ce(733C>G) alleles did not have time to become widespread but remain concentrated within families. These findings have considerable impact for typing and transfusion strategy in our population, increasing the pool of compatible units for Fy(b-) individuals requiring chronic transfusion. Possible difficulties in transfusion t...
Source: BioMed Central - May 6, 2008 Category: Journals (General) Authors: Carlos M Cotorruelo, Silvana V Fiori, Silvia E Garcia Borras, Liliana L Racca, Claudia S Biondi and Amelia L Racca Source Type: journals

Clinical effects of different types of red cell concentrates in patients with thalassemia and sickle cell disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of thalassemia is still essentially based on continuous transfusion supporting using red cell concentrates (RCC) prepared in different ways. For patients with sickle-cell disorders, either urgent or chronic red blood cell transfusion therapy, is widely used in the management of sickle cell disease (SCD) because it reduces HbS level and generally prevents recurrent vaso-occlusive disease (VOD). Recently, the introduction of prestorage filtration to remove leukocytes and the use of techniques for multicomponent donation have increased the types of blood components available for transfusion purposes. The cli...
Source: Transfusion Clinique et Biologique - April 21, 2008 Category: Hematology Authors: Cabibbo S, Fidone C, Antolino A, Manenti OG, Garozzo G, Travali S, Bennardello F, Di Stefano R, Bonomo P Tags: Transfus Clin Biol Source Type: journals