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This page shows you the latest news and research items in this category.

Does Cow's Milk Protein Elimination Diet Have a Role on Induction and Maintenance of Remission in Children with Ulcerative Colitis?
ConclusionsIn conclusion, data of this pediatric, randomized trial suggest that CMP elimination has no role in the management of UC in non‐sensitized children.©2013 The Author(s)/Acta Pædiatrica ©2013 Foundation Acta Pædiatrica (Source: Acta Paediatrica)
Source: Acta Paediatrica - February 27, 2013 Category: Pediatrics Authors: Caterina Strisciuglio, Eleonora Giannetti, Massimo Martinelli, Elisa Sciorio, Annamaria Staiano, Erasmo Miele Tags: Regular Article Source Type: research

Avaxia doses first patient in ulcerative colitis drug study
Clinical-stage biopharmaceutical company Avaxia Biologics has dosed the first patient in a Phase Ib clinical study of its gut-targeted anti-TNF antibody, for the treatment of ulcerative colitis. (Source: Drug Development Technology)
Source: Drug Development Technology - February 26, 2013 Category: Pharmaceuticals Source Type: news

Biological therapy for Crohn's disease in a liver transplant patient
Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders of the gastrointestinal tract, which comprises two main disease types, Crohn's Disease (CD) and ulcerative colitis (UC). Biological therapy with anti‐tumor necrosis factor (TNF) drugs such as infliximab, adalimumab and certolizumab has represented a significant advance in the treatment of CD.1 These agents have shown good efficacy and adverse events similar to placebo in randomized controlled trials and its use has recently been broadened to UC.2 This implies greater use of these medications within our clinical practice. However, limited experi...
Source: Chinese Journal of Digestive Diseases - February 26, 2013 Category: Gastroenterology Authors: Rogger Alvaro Bendezú García, Marco Antonio Rodríguez Manrique, Alvaro Hernández Martínez, Marta Lázaro Sáez, Gustavo Oliver Patrón Román, Sergio Amat Alcaraz, Jose Luis Vega Sáenz Tags: Case Report Source Type: research

Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation: Trichuris muris-induced colitis genetic study
Conclusion: Genetic susceptibility to induced colonic mucosal inflammation in the mouse is conserved at Tm3 and overlays Cdcs1.1. Genes central to the maintenance of intestinal homeostasis reside within this locus, implicating several candidates in susceptibility to colonic inflammation. Combined methodology incorporating genetic, transcriptional and pathway data allowed identification of biologically relevant candidate genes, with Vav3 newly implicated as a colitis susceptibility gene of functional relevance. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - February 26, 2013 Category: Genetics & Stem Cells Authors: Scott LevisonPaul FisherJenny HankinsonLeo ZeefSteve EyreWilliam OllierJohn McLaughlinAndy BrassRichard GrencisJoanne Pennock Source Type: research

Characteristics of inflammatory bowel disease with an onset before eight years of age: A multicenter epidemiological survey in Japan
ConclusionOur results suggest that, in Japan, the pathogenesis of IBD in infants and children may differ from that in Western countries, and that the characteristics of early childhood‐onset IBD are distinct from those of school age‐onset IBD. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 26, 2013 Category: Gastroenterology Authors: Shun‐ichi Maisawa, Mika Sasaki, Shinobu Ida, Keiichi Uchida, Seiichi Kagimoto, Toshiaki Shimizu, Atsushi Yoden Tags: Gastroenterology Source Type: research

Gastrointestinal: Herpes vasculitis in an ulcerative colitis patient
(Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 26, 2013 Category: Gastroenterology Authors: J‐M Wong, P‐H Huang, S‐Ch Wei Tags: Education and Imaging Source Type: research

Incidence and clinical characteristics of Inflammatory Bowel Disease in a developed region of Guangdong province, China: A Prospective Population‐Based Study
ConclusionsThis is the first prospective, population‐based IBD epidemiologic study in a developed region of China. The incidence of IBD is similar to that in Japan and Hong Kong, but lower than that in South Korea and Western countries. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 22, 2013 Category: Gastroenterology Authors: Zhirong Zeng, Zhenhua Zhu, Yuyu Yang, Weishan Ruan, Xiabiao Peng, Yuhuan Su, Lin Peng, Jinquan Chen, Quan Yin, Chao Zhao, Haihua Zhou, Shuai Yuan, Yuantao Hao, Jiaming Qian, Siew Chien Ng, Minhu Chen, Pinjin Hu Tags: Clinical Gastroenterology Source Type: research

Immune commences ulcerative colitis drug Phase II study
Israel-based Immune Pharmaceuticals has commenced a double-blind, parallel group, randomised and placebo-controlled Phase II study of bertilimumab for the treatment of moderate-to-severe ulcerative colitis. (Source: Drug Development Technology)
Source: Drug Development Technology - February 21, 2013 Category: Pharmaceuticals Source Type: news

Histopathologic study of the rectum in 1,438 consecutive rectal specimens in a single Japanese hospital: I. benign lesions.
Abstract The author investigated histopathology of 1,438 consecutive rectal specimens in the last 10 years of our pathology laboratory in Japan. A computer review of pathologic reports was done. Observations of pathologic slides were performed, when appropriate. The rectal specimens were composed of 1,022 benign lesions and 416 malignant lesions. The 1,022 benign lesions were composed non-specific proctitis (n=460, 45%), adenoma (n=248, 24%), ulcerative colitis (n=98, 10%), hyperplastic polyp (n=54, 5%), carcinoma in adenoma (n=40, 4%), rectal ulcer (n=37, 4%), serrated adenoma (n=24, 2%), hyperplastic nodule (n=21...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Catalase gene C‐262T polymorphism: importance in ulcerative colitis
ConclusionsThis study indicates that CAT C‐262T polymorphism may be associated with UC and the ‐262C/T genotype may be a risk factor for the disease. Further studies are needed to confirm the results. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 21, 2013 Category: Gastroenterology Authors: Siamak Khodayari, Zivar Salehi, Saba Fakhrieh Asl, Keyvan Aminian, Nadia Mirzaei Gisomi, Saeideh Torabi Dalivandan Tags: Experimental Gastroenterology Source Type: research

Study Finds No Tie Between Acne Drug Accutane and Crohn'S, Colitis
New data involving 45,000 women may settle the question, experts saySource: HealthDay Related MedlinePlus Pages: Acne, Crohn's Disease, Ulcerative Colitis (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - February 20, 2013 Category: Consumer Health News Source Type: news

Recent Developments in the Treatment of Inflammatory Bowel Disease
Abstract Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases that have been treated with corticosteroids, 5‐aminosalicates and thiopurines, but therapeutic options have been broadened with the arrival of anti‐ tumor necrosis factor (TNF) antibodies. In this article we review the current evidence based approach to inflammatory bowel disease (IBD), the modifications that have been made to existing therapies and discuss new drugs that have shown success in clinical trials. The new drugs discussed here are those that disturb lymphocyte homing to the gut (natalizumab, vedolizumab and anti‐ mucos...
Source: Chinese Journal of Digestive Diseases - February 19, 2013 Category: Gastroenterology Authors: Svend T. Rietdijk, Geert R. D'haens Tags: Invited Review Source Type: research

Hydroxylases as therapeutic targets in inflammatory bowel disease
p; Cormac T Taylor (Source: Laboratory Investigation AOP)
Source: Laboratory Investigation AOP - February 18, 2013 Category: Laboratory Medicine Authors: Eoin P CumminsGlen A DohertyCormac T Taylor Tags: Crohn’s disease DMOG epithelial barrier therapeutics ulcerative colitis Source Type: research

PillCam colon capsule endoscopy versus conventional colonoscopy for the detection of severity and extent of ulcerative colitis
ConclusionPCCE provides an outstanding performance in the detection of the severity and extent of active UC. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 18, 2013 Category: Gastroenterology Authors: Chen An Ye, Yun Jie Gao, Zhi Zheng Ge, Jun Dai, Xiao Bo Li, Han Bing Xue, Zhi Hua Ran, Yun Jia Zhao Tags: Original article Source Type: research

Mesalazine granules once-daily dose provides similar results to twice-daily dose in patients with active, left-sided ulcerative colitis.
The objective of the MOTUS study was to show non-inferiority of once-daily mesalazine versus twice-daily dosing for the induction of remission in active ulcerative colitis. As many patients with ulcerative colitis experience left-sided disease, the aim of the new sub analysis was to assess specifically the efficacy in patients with left-sided ulcerative colitis. (Source: NeLM - News)
Source: NeLM - News - February 15, 2013 Category: Drugs & Pharmacology Source Type: news

The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease
Abstract: Clinical and experimental observations in animal models indicate that intestinal commensal bacteria are involved in the initiation and amplification of inflammatory bowel disease (IBD). As the majority of colonic bacteria cannot be identified by culture techniques, the aim of this study was to use sequence-based methods to investigate and characterize the composition of the dominant fecal microbiota in both patients with inflammatory bowel disease and healthy subjects. Fecal microbiota was isolated and quantified using real-time quantitative polymerase chain reaction. Denaturing gradient gel electrophoresis (DGGE...
Source: Diagnostic Microbiology and Infectious Disease - February 14, 2013 Category: Microbiology Authors: Sumei Sha, Bin Xu, Xin Wang, Yongguo Zhang, Honghong Wang, Xiangyun Kong, Hongwu Zhu, Kaichun Wu Tags: Bacteriology Source Type: research

Letter: factors that may predict response to ciclosporin in ulcerative colitis
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 14, 2013 Category: Drugs & Pharmacology Authors: K. Farkas, A. Bálint, F. Nagy, Z. Szepes, M. Szűcs, T. Wittmann, T. Molnár Tags: Letters to the Editors Source Type: research

Letter: factors that may predict response to ciclosporin in ulcerative colitis – authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 14, 2013 Category: Drugs & Pharmacology Authors: T. Katsuno, K. Saito, O. Yokosuka Tags: Letters to the Editor Source Type: research

Neuromyotonia: Clinical, Electrophysiological and Immunological Findings of 4 Cases (P02.244)
CONCLUSIONS: The diagnosis of neuromyotonia is accomplished primarily through clinical and electrophysiological findings. Electromyography often confirms diagnosis by the presence of neuromyotonic discharges. The dosage of anti-CKVD has a low sensitivity for the diagnosis of disease. The association with autoimmune diseases can be observed, as described in this series.Disclosure: Dr. Scola has received personal compensation for activities with Merck Serono as scientific advisor board. Dr. Paranhos has nothing to disclose. Dr. Lorenzoni has nothing to disclose. Dr. Kay has nothing to disclose. Dr. Vincent has received perso...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Scola, R., Miranda, A., Lorenzoni, P., Kay, C., Vincent, A., Werneck, L. Tags: P02 Clinical Neurophysiology: EEG and IONM Source Type: research

Evaluation of long‐term function, complications, quality of life and health status after restorative proctocolectomy with ileo neo rectal and with ileal pouch anal anastomosis for ulcerative colitis
ConclusionComparison of INRA and RPC on an intention to treat basis was not considered to be realistic due to the high intraoperative conversion rate and the failures in the INRA group. RPC remains the procedure of choice for restoring intestinal continuity after proctocolectomy for ulcerative colitis.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland (Source: Colorectal Disease)
Source: Colorectal Disease - February 13, 2013 Category: Gastroenterology Authors: Joost T. Heikens, Jolanda Vries, Dirk J. Jong, Brenda L. den Oudsten, Wim Hopman, Joannes M.M. Groenewoud, Marion B. Kolk, Hein G. Gooszen, Cees J.H.M. Laarhoven Tags: Original Article Source Type: research

Recent Advances Using Immunomodulators for Inflammatory Bowel Disease.
Abstract Use of the immunomodulators thiopurines and methotrexate (MTX) in the treatment of inflammatory bowel disease (IBD), i.e., Crohn's disease and ulcerative colitis (UC), is considered to be good clinical practice. However, despite being administered to a considerable number of IBD patients over the years, questions remain about the most rational treatment regimens of azathioprine (AZA), 6-mercaptopurine (6-MP), and MTX, and results from a range of recent studies necessitate increased attention to how to optimize the use of these immunomodulators. First and foremost, it is of utmost importance to define the s...
Source: The Journal of Clinical Pharmacology - February 13, 2013 Category: Drugs & Pharmacology Authors: Nielsen OH, Bjerrum JT, Herfarth H, Rogler G Tags: J Clin Pharmacol Source Type: research

Looking for predictive factors of clinical response to adsorptive granulocyte and monocyte apheresis in patients with ulcerative colitis: markers of response to GMA
Certain factors, such as a recent relapse and low white blood cell counts, are predictive of successful treatment of ulcerative colitis using adsorptive granulocyte and monocyte apheresis (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - February 12, 2013 Category: Gastroenterology Authors: Yoko YokoyamaMikio KawaiKen FukunagaKoji KamikozuruKazuko NagaseKoji NogamiTomoaki KonoYoshio OhdaMasaki IimuroNobuyuki HidaShiro NakamuraHiroto MiwaTakayuki Matsumoto Source Type: research

S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity [Patient-Oriented and Epidemiological Research]
Signaling through sphingosine-1-phosphate receptor1 (S1P1) promotes blood vessel barrier function. Degradation of S1P1 results in increased vascular permeability in the lung and may explain side effects associated with administration of FTY720, a functional antagonist of the S1P1 receptor that is currently used to treat multiple sclerosis. Ulcerative colitis (UC) is characterized by an increased density of abnormal vessels. The expression or role of S1P1 in blood vessels in the colon has not been investigated. In the present study, we show that S1P1 is overexpressed in the colonic mucosa of UC patients. This increase in S1...
Source: The Journal of Lipid Research - February 12, 2013 Category: Lipidology Authors: Montrose, D. C., Scherl, E. J., Bosworth, B. P., Zhou, X. K., Jung, B., Dannenberg, A. J., Hla, T. Tags: Patient-Oriented and Epidemiological Research Source Type: research

Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice
Conclusion: These results suggest that GFO has potential therapeutic value as an adjunct therapy for ulcerative colitis. (Source: Nutrition)
Source: Nutrition - February 11, 2013 Category: Nutrition Authors: Erina Joo, Shunsuke Yamane, Akihiro Hamasaki, Norio Harada, Tetsuro Matsunaga, Atsushi Muraoka, Kazuyo Suzuki, Daniela Nasteska, Toru Fukushima, Tatsuya Hayashi, Hidemi Tsuji, Kenichiro Shide, Kinsuke Tsuda, Nobuya Inagaki Tags: Basic Nutritional Investigations Source Type: research

Restorative proctocolectomy impairs fertility and pregnancy outcomes in women with ulcerative colitis
ConclusionRPC is associated with an increased risk of infertility, similar gestation duration and lower birth weight. Female candidates for RPC who have not finished family planning should be counseled accordingly.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland (Source: Colorectal Disease)
Source: Colorectal Disease - February 11, 2013 Category: Gastroenterology Authors: H. Tulchinsky, F. Averboukh, N. Horowitz, M. Rabau, J.M. Klausner, Z. Halpern, I. Dotan Tags: Original Article Source Type: research

[Neurological complications of inflammatory bowel diseases.]
Abstract Inflammatory bowel diseases, such as Crohn's disease, ulcerative colitis, autoantibody driven celiac disease and infectious Whipple's disease can all be associated with neurological symptoms. The neurological manifestation may occur even before the gastrointestinal symptoms or the enteropathic symptoms can even be absent as in celiac disease. These diseases can be caused by malresorption and lack of vitamins due to enteral inflammation as well as (auto-)immunological mechanisms and drug-associated side effects. Thus, inflammatory bowel diseases have to be considered in the differential diagnosis. In this r...
Source: Der Nervenarzt - February 8, 2013 Category: Neurology Authors: Cieplik N, Stangel M, Bachmann O Tags: Nervenarzt Source Type: research

Warner Chilcott Announces FDA Approval of New Ulcerative Colitis Product Delzicol
DUBLIN, Ireland, Feb. 5, 2013 -- Warner Chilcott plc today announced that the United States Food and Drug Administration (FDA) has approved its new 400 mg mesalamine product indicated for the treatment of ulcerative colitis. The product will be... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 6, 2013 Category: Drugs & Pharmacology Source Type: news

BMJ review: Ulcerative colitis
Source: BMJ Area: News The BMJ has featured an evidence based review on the diagnosis and management of ulcerative colitis. The following questions are addressed: . What is ulcerative colitis and who gets it? . What are the clinical features and associated conditions? . What is the underlying pathophysiology of ulcerative colitis? . How is ulcerative colitis diagnosed? . What is the prognosis? . What are the treatment options? . Monitoring of drug therapy in ulcerative colitis . Colorectal cancer screening in ulcerative colitis . Osteoporosis in ulcer...
Source: NeLM - News - February 6, 2013 Category: Drugs & Pharmacology Source Type: news

Uceris (Budesonide) for Treating Ulcerative Colitis
Uceris (budesonide) is glucocorticoid receptor that is indicated for the treatment of ulcerative colitis. It is developed by US-based biopharmaceutical company Santarus, in collaboration with Cosmo Technologies. (Source: Drug Development Technology)
Source: Drug Development Technology - February 5, 2013 Category: Pharmaceuticals Source Type: news

Warner Chilcott Announces FDA Approval of New Ulcerative Colitis Product
DUBLIN, Ireland, Feb. 5, 2013 -- (Healthcare Sales & Marketing Network) -- Warner Chilcott plc (WCRX) today announced that the United States Food and Drug Administration (FDA) has approved its new 400 mg mesalamine product indicated for the treatment of ul... Biopharmaceuticals, Gastroenterology, FDAWarner Chilcott, DELZICOL, mesalamine, ulcerative colitis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 5, 2013 Category: Pharmaceuticals Source Type: news

IL-22 is related to development of human colon cancer by activation of STAT3
Conclusion: In this study we demonstrated that excessive IL-22 in the CC and UC microenvironment leads to tumor growth, inhibition of apoptosis, and promotion of metastasis depend on STAT3 activation. (Source: BMC Cancer)
Source: BMC Cancer - February 5, 2013 Category: Cancer & Oncology Authors: Runqiu JiangHaiyang WangLei DengJiajie HouRuihua ShiMing YaoYun GaoAihua YaoXuehao WangLianzhen YuBeicheng Sun Source Type: research

Adenoma‐like and non‐adenoma‐like dysplasia‐associated lesion of mass in ulcerative colitis patients
Abstract An increased risk of colorectal cancer (CRC) has been revealed in ulcerative colitis (UC) patients. There are two patterns of growth of dysplasia in UC, commonly classified as adenoma‐like dysplasia‐associated lesion of mass (DALM) and non‐adenoma‐like DALM, the latter of which has a high risk of concurrent malignancy and often requires colectomy. Unfortunately, sometimes non‐adenoma‐like DALM has endoscopic features similar to those of adenoma‐like DALM. Therefore, new endoscopic techniques to facilitate the distinction between adenoma‐like and non‐adenoma‐like DALMs have been proposed. (Sourc...
Source: Chinese Journal of Digestive Diseases - February 4, 2013 Category: Gastroenterology Authors: Ying Xuan Chen, Liang Qiao Tags: Leading Article Source Type: research

Proteomic Patterns of Colonic Mucosal and Submucosal Tissues Delineates Crohn's Colitis and Ulcerative Colitis
Conclusion/Clinical relevanceThis information may provide new‐avenues for the development of novel evidenced personalized therapeutic targets. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - February 4, 2013 Category: Biochemistry Authors: Michael W. Schäffer, Erin H. Seeley, Joan C. Smith, Roberta L. Muldoon, Roger K. Moreira, Purva P. Gopal, William V. Chopp, Mary K. Washington, Duane T. Smoot, Harold L. Moses, Billy R. Ballard, Alan J. Herline, Richard M. Caprioli, Samuel E. Adunyah, Am Tags: Research Article Source Type: research

Cytomegalovirus infection associated with onset of ulcerative colitis
Conclusion: Synchronous CMV colitis is not routinely investigated in newly diagnosed UC patients. Together with a recent observation in animal studies, it is plausible that a subset (a few to several per cent) of UC patients develop synchronous CMV infection. Further studies are needed to elucidate the plausibility. (Source: BMC Research Notes)
Source: BMC Research Notes - February 2, 2013 Category: Research Authors: Mitsuro ChibaToru AbeSatoko TsudaIwao Ono Source Type: research

The prevalence and risk factors of cytomegalovirus infection in inflammatory bowel disease in Wuhan, central China
Conclusions: CMV positive rate in IBD patients was significantly higher, than in healthy controls. The use of aminosalicylic acid, corticosteroid, immunosuppressants, pancolitis and severe IBD patients seemed to be more susceptible to CMV infection in univariate analysis of risk factors. However, no risk factor was found to be significantly correlated with CMV infection in multivariate analysis of risk factors. (Source: Virology Journal)
Source: Virology Journal - February 1, 2013 Category: Virology Authors: Fengming YiJie ZhaoRishi Vishal LuckheeramYuan LeiChanggao WangSha HuangLu SongWei WangBing Xia Source Type: research

Trans‐pouch prostate biopsy: A word of caution
We wish to draw to the readers’ attention the potential dangers of prostate biopsy undertaken through a transanal route in patients having an ileoanal pouch.Our patient underwent restorative proctocolectomy for ulcerative colitis in 1995 and enjoyed excellent function (4 evacuations per day and occasionally 1 nocturnal) without any episodes of pouchitis. In February 2012, aged 74, he presented to the urologists with lower urinary tract symptoms and a PSA of 9. It was felt that the presence of an ileal pouch would make digital assessment of the prostate uninformative and he subsequently underwent an ultrasound‐guided tr...
Source: Colorectal Disease - February 1, 2013 Category: Gastroenterology Authors: Richard E Lovegrove, Ami Mishra, Neil J Mortensen Tags: Correspondence Source Type: research

Considerations and complications in patients undergoing ileal pouch anal anastomosis.
This article outlines both the early and late complications that can occur after IPAA, as well as the workup and management of these potentially morbid conditions. PMID: 23177068 [PubMed - indexed for MEDLINE] (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - February 1, 2013 Category: Surgery Authors: Francone TD, Champagne B Tags: Surg Clin North Am Source Type: research

[Probiotics in gastroenterology - from a different angle.]
Abstract After a short overview of the history of probiotics, the author presents the development of human intestinal microflora based on the newest genetic data and the microbiological features of main probiotics. The indications of probiotic administration have been defined and extended in recent years. The author reviews significant results of probiotic treatment in some gastrointestinal diseases based on meta-analytical data. Probiotics are useful in preventing and treating diarrhoea caused by antibiotics and Clostridium difficile caused diarrhoea. In the treatment of Helicobacter pylori infection, preparations...
Source: Orvosi Hetilap - February 1, 2013 Category: Journals (General) Authors: Buzás GM Tags: Orv Hetil Source Type: research

Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN Study
Conclusion Ten years after disease onset IBD patients had an increased RR for DP as compared with the background population. The youngest patients had the highest RR. Markers of severe disease course predicted WD. (Source: Gut)
Source: Gut - January 31, 2013 Category: Gastroenterology Authors: Hoivik, M. L., Moum, B., Solberg, I. C., Henriksen, M., Cvancarova, M., Bernklev, T., IBSEN Group Tags: Crohn's disease, Ulcerative colitis Inflammatory bowel disease Source Type: research

Medication adherence and persistence in the treatment of Canadian ulcerative colitis patients: analyses with the RAMQ database
Conclusions: The majority of patients with UC exhibited low adherence and persistence to mesalamine treatments. Various determinants of improved adherence and persistence were identified. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - January 30, 2013 Category: Gastroenterology Authors: Jean LachaineLinnette YenCatherine BeaucheminPaul Hodgkins Source Type: research

Elective versus emergency surgery for ulcerative colitis: a National Surgical Quality Improvement Program analysis
Conclusions: In the era of advanced UC medical therapy, the need for emergency surgery still exists and is associated with substantial morbidity and mortality. Data are needed to determine if earlier selection of surgery would be beneficial. (Source: American Journal of Surgery)
Source: American Journal of Surgery - January 30, 2013 Category: Surgery Authors: Supriya S. Patel, Madhukar S. Patel, Melanie Goldfarb, Adrian Ortega, Glenn T. Ault, Andreas M. Kaiser, Anthony J. Senagore Tags: Presidential Address Source Type: research

Budesonide MMX and Mesalamine to Induce Remission in Patients With Ulcerative Colitis
We read with interest about the randomized, controlled trial (RCT) by Sandborn et al, which deserve some comments concerning the methodology and the interpretation of the results. (Source: Gastroenterology)
Source: Gastroenterology - January 28, 2013 Category: Gastroenterology Authors: Valeria Criscuoli, Emanuele Sinagra, Mario Cottone Tags: Correspondence Source Type: research

Reply
We appreciated Criscuoli, Sinagra, and Cottone's comments regarding our manuscript, “Once-Daily Budesonide MMX Extended-Release Tablets Induce Remission in Patients with Mild to Moderate Ulcerative Colitis: Results from the CORE I Study.” Their primary concern surrounds the dose of Asacol utilized in the study (2.4 g/d) and the performance of the drug in the clinical trial that was designed to examine the efficacy of MMX budesonide for mild to moderately active ulcerative colitis. (Source: Gastroenterology)
Source: Gastroenterology - January 28, 2013 Category: Gastroenterology Authors: William J. Sandborn, Simon Travis, David Ballard Tags: Correspondence Source Type: research

Stool DNA testing for the detection of colorectal neoplasia in patients with inflammatory bowel disease
ConclusionThese findings demonstrate the feasibility of stool DNA testing for non‐invasive detection of colorectal neoplasia associated with inflammatory bowel disease. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 26, 2013 Category: Drugs & Pharmacology Authors: J. B. Kisiel, T. C. Yab, F. T. Nazer Hussain, W. R. Taylor, M. M. Garrity‐Park, W. J. Sandborn, E. V. Loftus, B. G. Wolff, T. C. Smyrk, S. H. Itzkowitz, D. T. Rubin, H. Zou, D. W. Mahoney, D. A. Ahlquist Tags: SuperFast Source Type: research

Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case--control study in India
We examined the abundance and diversity of Clostridium leptum group, an important group of carbohydrate-fermenting bacteria, in the feces of patients with IBD and compared them with healthy controls. Methods: Seventeen healthy controls (HC), 20 patients with Crohn's disease (CD) and 22 patients with ulcerative colitis (UC) participated in the study. DNA extracted from fecal samples was amplified by PCR targeting 16S rRNA gene sequences specific to C. leptum group. The PCR product was subjected to temporal temperature gradient electrophoresis (TTGE) and the number and position of individual bands were noted and diversity wa...
Source: BMC Gastroenterology - January 26, 2013 Category: Gastroenterology Authors: Jayakanthan KabeerdossVijayalakshmi SankaranSrinivasan PugazhendhiBalakrishnan Ramakrishna Source Type: research

Which IBD Patients Should You Refer to a Specialist?Which IBD Patients Should You Refer to a Specialist?
When is it appropriate for a primary care provider to refer patients with ulcerative colitis or Crohn disease to a gastroenterologist? Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 25, 2013 Category: Consumer Health News Tags: Gastroenterology Ask the Expert Source Type: news

Infliximab‐associated Blastomycosis dermatitidis in treatment of ulcerative colitis
(Source: Colorectal Disease)
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: D. A. McCann, H. L. Smith Tags: Case report Source Type: research

Simple urine test picks up mesalamine non-adherence
A readily available urine test could identify ulcerative colitis patients who are non-adherent to their mesalamine therapy, research shows. (Source: MedWire News - Gastroenterology)
Source: MedWire News - Gastroenterology - January 24, 2013 Category: Gastroenterology Source Type: news

Family planning and inflammatory bowel disease: the patient and the practitioner
Conclusions. There is a significant patient knowledge deficit about pregnancy and IBD resulting in unwarranted fears and anxiety. Further evidence based education for GP’s with increased gastroenterologist/IBD nurse specialist support should maximize exploitation of health promotion opportunities to electively address this issue. (Source: Family Practice)
Source: Family Practice - January 23, 2013 Category: Primary Care Authors: Toomey, D., Waldron, B. Tags: Original Article Source Type: research

Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice.
Abstract The quaternary ammonium salt, sanguinarine (SANG), is of great practical and research interest because of its pronounced, widespread physiological effects, which promote anti-microbial and anti-inflammatory responses in experimental animals. Although SANG is originally shown to possess anti-inflammatory properties and it has been used to treat various inflammatory diseases, its effects on ulcerative colitis have not been previously explored. The aim of the present study is to evaluate the effect of SANG on acetic acid-induced ulcerative colitis in mice. Experimental animals received SANG (1, 5 and 10mg/kg,...
Source: Toxicology and Applied Pharmacology - January 23, 2013 Category: Toxicology Authors: Niu X, Fan T, Li W, Huang H, Zhang Y, Xing W Tags: Toxicol Appl Pharmacol Source Type: research