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This page shows you the latest news and research items in this category.

Periorbital Reconstruction Following Removal of a Large Verrucous Carcinoma
(Source: Dermatologic Surgery)
Source: Dermatologic Surgery - April 16, 2013 Category: Dermatology Authors: Gregory J. Griepentrog, Rosemarie H. Liu, Mark J. Lucarelli Tags: Reconstructive Conundrum Source Type: research

Current Management Strategies for Verrucous Hyperkeratosis and Verrucous Carcinoma
Proliferative verrucous leukoplakia, a lesion of unknown origin with no strictly defined diagnostic criteria, is worthy of great clinical concern and scrutiny. Treatment options vary, with no consensus regarding the most efficient and effective strategy. Further complicating the unusual biology and behavior of this lesion is its usual multifocal presentation and progression, with lifelong vigilance required after treatment. Verrucous carcinoma is a progressive lesion with high recurrence and 5-year survival rates. Surgery remains the preferred treatment. Further investigation into the combination of surgery and antiviral a...
Source: Oral and Maxillofacial Surgery Clinics - February 1, 2013 Category: ENT & OMF Authors: James J. Sciubba, Joseph I. Helman Source Type: research

Semiquantitative histologic evaluation improves diagnosis of esophageal carcinoma cuniculatum on biopsy
& Xiuli Liu (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - January 25, 2013 Category: Pathology Authors: Derrick ChenJohn R GoldblumMichael LandauThomas W RiceRish K PaiShu-Yuan XiaoXiuli Liu Tags: candida esophagitis carcinoma cuniculatum dyskeratosis esophagus hyperkeratosis mucosal biopsy neutrophil squamous cell carcinoma Source Type: research

Immunohistochemical study of p53, Ki-67, MMP-2 and MMP-9 expression at invasive front of squamous cell and verrucous carcinoma in oral cavity.
Abstract Squamous cell carcinoma (SCC) is the most common malignancy in the oral cavity. Verrucous carcinoma (VC) is a lower grade subtype of SCC with pathological similarities but different management. Tumor invasive front (TIF) is a dynamic location in the differentiation of malignancies. p53 is a tumor suppressor and Ki-67 a proliferation marker. Matrix metalloproteinases 2 and 9 are involved in the tumor invasiveness. We assessed these markers in TIF of oral SCC and VC to find more precise grading scales. We studied the expression of markers in the invasive front of 42 cases of SCC (21 high and 21 low grade), 2...
Source: Pathology, Research and Practice - December 27, 2012 Category: Pathology Authors: Mohtasham N, Babakoohi S, Shiva A, Shadman A, Kamyab-Hesari K, Shakeri MT, Sharifi-Sistani N Tags: Pathol Res Pract Source Type: research

Carcinoma Cuniculatum: A Potentially Underdiagnosed Entity in the Absence of Clinical Correlation
We present 6 additional cases of CC from the attached gingiva and vestibular/buccal mucosa. The average age at presentation was 66.5 yrs. All of our cases except 1 were treated conservatively: 1 required an en-bloc resection to achieve clear margins. In multiple cases of this study, treatment delays resulted from under-interpretation of small or superficial biopsies. Patients subsequently went on to obtain definitive diagnoses only after clinical correlation revealed an appearance inconsistent with a benign process. Therefore, since a pathognomonic microscopic appearance is often not seen in these cases, the caveat is give...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - October 19, 2012 Category: ENT & OMF Tags: 16th International Congress on Oral Pathology and Medicine and 20th Brazilian Congress of Oral Medicine and Pathology 2012 (São Pedro-Brazil, 30th July – 03rd August 2012) Source Type: research

A distinct entity: The lesion looked like a wart but was, in fact, something far more unusual
A 74-year-old woman presented with a 9-month history of a white slow-growing warty lesion on her vulva (). She reported mild pruritus, but she had not experienced any significant pain or lower urinary tract symptoms. Several antiwart creams were prescribed but none produced a response. A deep surgical biopsy led to a final diagnosis of carcinoma cuniculatum (CC) (). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - October 19, 2012 Category: OBGYN Authors: Husein Husein El Ahmed, Carmen Dulanto-Campos Tags: Images in Gynecology Source Type: research

Oral verruciform xanthoma: a case report and literature review
Oral verruciform xanthoma represents a rare entity, which affects mainly oral mucosa. A 73-years-old woman presented an asymptomatic soft tissue mass on the tongue. Physical examination of oral mucosa revealed a well-circumscribed, sessile nodule with a fibrous consistency and whitish verrucous surface fixed to the lateral edge of the tongue. These findings were suggestive of verruca vulgaris. Histopathological examination revealed a partial parakeratosis with uniform elongated epithelial ridges, parakeratin plugs and exocytosis. The connective tissue was composed by uniform papillae filled by large vacuolated foam. The Pe...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 17, 2012 Category: ENT & OMF Tags: Abstracts presented at the Annual Meeting of the American Academy of Oral and Maxillofacial Pathology (AAOMP), June 22-27, 2012 Source Type: research

Intraosseous verrucous carcinoma arising from an infected dentigerous cyst – a case report
Intraosseous verrucous carcinoma arising from an odontogenic cyst is extremely rare. Only 3 cases have been reported in the English literature up to date. In this article, we presented an intraosseous verrucous carcinoma arising from an infected dentigerous cyst in a 74-year-old male patient. The patient presented with a left mandibular swelling with recurrent pus discharge from the lingual gingiva of tooth #35. Although antibiotic medication was given to the patient, the swelling persisted. The patient finally visited our hospital for treatment. The mandibular occlusal radiograph revealed a prominent lingual cortical plat...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 17, 2012 Category: ENT & OMF Tags: Abstracts presented at the Annual Meeting of the American Academy of Oral and Maxillofacial Pathology (AAOMP), June 22-27, 2012 Source Type: research

Extensive verrucous carcinoma in maxilla - case report
Verrucous carcinoma is a highly differentiated variant of squamous cell carcinoma that exhibit slow growing, locally destructive behavior and rarely metastasizes. The most common sites of occurrence in oral cavity are mandibular alveolar bone crest, buccal mucosa and hard palate. A 63-years old male patient was indicated to the Maxillofacial Surgery Department with a painless lesion on the right side of the maxilla surface. The clinical examination showed an extensive exophytic white lesion with a papillary surface. The clinical diagnosis was verrucous carcinoma and an incisional biopsy was performed. The histopathological...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 17, 2012 Category: ENT & OMF Tags: Abstracts presented at the Annual Meeting of the American Academy of Oral and Maxillofacial Pathology (AAOMP), June 22-27, 2012 Source Type: research

A clinicopathological and immunohistochemical study of oral carcinoma cuniculatum (CC)
Background/objective: Carcinoma cuniculatum (CC) is a distinct variant of oral squamous cell carcinoma (SCC) and remains a histopathological challenge to pathologists. The purpose of this study was to illustrate the clinicopathological and immunohistochemical factors of CC. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 17, 2012 Category: ENT & OMF Tags: Abstracts presented at the Annual Meeting of the American Academy of Oral and Maxillofacial Pathology (AAOMP), June 22-27, 2012 Source Type: research

Verrucous carcinoma in epidermolysis bullosa simplex is possibly associated with a novel mutation in the keratin 5 gene
We describe the molecular background and the unusual course of the disease in a patient with EBS Dowling–Meara, severe keratoderma and a massive verrucous carcinoma. Skin and tumour samples from the patient were analysed using light microscopy, immunohistochemistry and immunofluorescence mapping. Mutation analysis of the KRT5 and KRT14 genes identified the novel KRT5 mutation p.E477D. Invasive tumour areas were characterized by downregulation of keratins 5 and 14, reduced and irregular desmocollin‐2 expression and increased expression of keratins 6, 16 and 17. Levels of Ki‐67 were increased and levels of E‐cadher...
Source: British Journal of Dermatology - September 7, 2012 Category: Dermatology Authors: H. Schumann, W. Roth, C. Has, A. Volz, C. Erfurt‐Berge, T.M. Magin, L. Bruckner‐Tuderman Tags: CASE REPORT Source Type: research

Carcinoma cuniculatum: Not a Verrucous Carcinoma
Carcinoma cuniculatum and verrucous carcinoma are both very well differentiated forms of squamous carcinoma and thus difficult to separate histopathologically from pseudocarcinomatous hyperplasia. The diagnosis of each often requires clinical‐pathologic correlation. In reviewing the literature it is evident that most authors consider carcinoma cuniculatum and verrucous carcinoma to be synonymous even though Aird's original two cases had no verrucous features. The purpose of this report is to record a case of carcinoma cuniculatum which the authors believe to be similar to those reported by Aird et al., to emphasize the d...
Source: Journal of Cutaneous Pathology - September 1, 2012 Category: Pathology Authors: Melanie J. Kubik, Ronald M. Rhatigan Tags: Original Article Source Type: research

The Use of Neoplastic Donors to Increase the Donor Pool
Abstract: The aim of the study was to evaluate the experience of the Centre-Sud Transplant Organization (OCST) area using cadaveric donor with neoplastic diseases to evaluate the possibility of transmission to recipients. From January 1, 2003, to December 31, 2010, the neoplastic risk has been reported to be 5.4% (377/4654 referred donors). In 2003, the number of donors with a tumor and their mean age were respectively: 60 (10.3%) and 59.6 ± 19.9; 2004: 33 (5.2%) and 61.4 ± 15.9; 2005: 32 (6%) and 62.8 ± 15.5; 2006: 46 (7%) and 60.7 ± 19.1; 2007: 51 (7%) and 58.9 ± 16; in 2008: 58 (7%) and 59.7 ± 19.6; 2009: 47 (7%)...
Source: Transplantation Proceedings - September 1, 2012 Category: Transplant Surgery Authors: P. Fiaschetti, R. Pretagostini, D. Stabile, D. Peritore, A. Oliveti, F. Gabbrielli, S. Cenci, A. Ricci, F. Vespasiano, W.F. Grigioni Tags: Donation and Allocation Source Type: research

[Study of αB-crystallin and its possible role of anti-apoptosis in oral verrucous carcinoma].
CONCLUSION: αB-crystallin may play a role of anti-apoptosis by inhibiting the activation of caspase-3 in oral verrucous carcinoma. Supported by National Natural Science Foundation of China (30872895) and Key Science and Technology Project of Hunan Provincial Science and Technology Department (2008FJ2011). PMID: 23135120 [PubMed - in process] (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - August 1, 2012 Category: Dentistry Authors: Quan HZ, Tang ZG, Zhao LL, Yao ZG, Wang BS, Xie S Tags: Shanghai Kou Qiang Yi Xue Source Type: research

Primary candidiasis and squamous cell carcinoma of the larynx: report of a case
We report an extremely rare case of squamous cell carcinoma of the vocal cord following primary candidiasis. A 62-year-old man presented to our department reporting a 1-month history of hoarseness. He underwent laryngeal microscopic surgery for a presumptive diagnosis of glottic carcinoma. Histopathologic examination revealed candidiasis and scattered moderate dysplasia. He was treated with itraconazole for 4 weeks, and followed up without any recurrence of candidiasis. However, the 42-month follow-up examination revealed a focal whitish lesion on the right true vocal cord, and a repeat biopsy of this area reveale...
Source: Surgery Today - July 28, 2012 Category: Surgery Tags: Surgery Today Source Type: research

Squamous cell carcinoma arising within verrucous carcinoma of the oral cavity: a case report.
Abstract The author herein reports a case of squamous cell carcinoma (SCC) arising within verrucous carcinoma (VC) of the hard palate. An 84-year-old woman was admitted to our hospital complaining of oral discomfort. Oral examination revealed a pedunculated verrucous tumor (15 x 15 mm) in the hard palate. A biopsy revealed verrucous tumor. Resection of the lesion with wide margins was performed. Grossly, the palate tumor was pedunculated and verrucous, but a depressed area (8 x 7 mm) was recognized. Microscopically, the verrucous ares showed verrucous proliferation of squamous epithelium with little cellular atypia...
Source: International Journal of Clinical and Experimental Pathology - June 22, 2012 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Differential expression of microRNAs miR‐21, miR‐31, miR‐203, miR‐125a‐5p and miR‐125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck
Conclusions: Differences between VC, SCC and normal epithelium in expression profiles of investigated molecules indicate their association with the pathogenesis and clinicopathological characteristics of VC. Our results suggest that some microRNAs and proteins, particularly miR‐125b, miR‐203 and p63, might be useful in the diagnosis of VC. (Source: Histopathology)
Source: Histopathology - June 13, 2012 Category: Pathology Authors: Katarina Odar, Emanuela Boštjančič, Nina Gale, Damjan Glavač, Nina Zidar Source Type: research

Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma
p; Renske DM Steenbergen (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 8, 2012 Category: Pathology Authors: Marta del PinoMaaike CG BleekerWim G QuintPeter JF SnijdersChris JLM MeijerRenske DM Steenbergen Tags: E6 expression human papillomavirus p16INK4A staining verrucous carcinoma Source Type: research

Oral Verrucous Carcinoma Mimicking a Chronic Candidiasis: A Case Report
Verrucous carcinoma has a special propensity to mimic benign lesions of the oral cavity. A case of the oral verrucous carcinoma in maxillary alveolar ridge, extending to buccal vestibule, cheek, and labial mucosa, which was diagnosed and initially treated as chronic candidiasis, is presented. Clinical, histopathological, and therapeutic considerations related to diagnosis of the verrucous carcinoma in the oral cavity are discussed. (Source: International Journal of Biomedical Imaging)
Source: International Journal of Biomedical Imaging - June 6, 2012 Category: Radiology Source Type: research

Verrucous Cell Carcinoma Arising From an Underlying Giant Keratoacanthoma
Keratoacanthoma is a well-known, fast-growing, benign squamous epithelial neoplasm that usually presents as a solitary, dome-shaped, pink or flesh-colored nodule developing a central keratin-filled crater. Few authors consider it to be a benign cutaneous tumor whereas others suggest that it should be regarded as a low-grade variant of cutaneous squamous cell carcinoma (SCC). A 21-year-old female presented with a firm, nontender, well-defined plaque with irregular margins measuring about 8 x 4 cm over the dorsal aspect of the right foot along with an exuberant growth from the plaque measuring 4 x 5cm. There was no lymphaden...
Source: The International Journal of Lower Extremity Wounds - June 4, 2012 Category: Surgery Authors: Bansal, M., Manchanda, K., Pandey, S. S. Tags: Case Report Source Type: research

[Aggressive course of intertoe verrucous carcinoma].
PMID: 22721489 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - June 1, 2012 Category: Dermatology Authors: Lamchahab FE, Guerrouj B, Bourra H, Marot L, Zouaidia F, Lamzaf O, El Yaacoubi M, Senouci K, Belgnoui FZ, Hassam B Tags: Ann Dermatol Venereol Source Type: research

Verrucous carcinoma in epidermolysis bullosa simplex possibly associated with a novel mutation in the keratin 5 gene.
We describe the molecular background and the unusual course of the disease in a patient with EBS Dowling-Meara, severe keratoderma and a massive verrucous carcinoma. Skin and tumour samples of the patient were analyzed using light microscopy, immunohistochemistry and immunofluorescence mapping. Mutation analysis of the KRT5 and KRT14 genes identified the novel KRT5 mutation p.E477D. Invasive tumour areas were characterized by down-regulation of keratins 5 and 14, by reduced and irregular desmocollin-2 expression, and increased expression of keratins 6, 16, and 17. Ki-67 was increased and E-cadherin was strongly reduced in ...
Source: The British Journal of Dermatology - May 28, 2012 Category: Dermatology Authors: Schumann H, Roth W, Has C, Volz A, Erfurt-Berge C, Magin TM, Bruckner-Tuderman L Tags: Br J Dermatol Source Type: research

Verrucous carcinoma in epidermolysis bullosa simplex possibly associated with a novel mutation in the keratin 5 gene
We describe the molecular background and the unusual course of the disease in a patient with EBS Dowling‐Meara, severe keratoderma and a massive verrucous carcinoma. Skin and tumour samples of the patient were analyzed using light microscopy, immunohistochemistry and immunofluorescence mapping. Mutation analysis of the KRT5 and KRT14 genes identified the novel KRT5 mutation p.E477D. Invasive tumour areas were characterized by down‐regulation of keratins 5 and 14, by reduced and irregular desmocollin‐2 expression, and increased expression of keratins 6, 16, and 17. Ki‐67 was increased and E‐cadherin was strongly r...
Source: British Journal of Dermatology - May 28, 2012 Category: Dermatology Authors: H. Schumann, W. Roth, C. Has, A. Volz, C. Erfurt‐Berge, T.M. Magin, L. Bruckner‐Tuderman Source Type: research

Subungual verrucous carcinoma with bone invasion
(Source: International Journal of Dermatology)
Source: International Journal of Dermatology - May 22, 2012 Category: Dermatology Authors: Yuta Kurashige, Yukihiko Kato, Ayako Hobo, Ryoji Tsuboi Tags: Case report Source Type: research

Mohs micrographic surgery for verrucous carcinoma of the anogenital area: report of two cases
Conclusions Early recognition of VC and the proper evaluation of deep biopsies will avoid misdiagnosis as SCC and may prevent the occurrence of unnecessary disfiguring interventions. The MMS technique may be considered as a surgical approach in genitoanal VC, although further research is required to confirm this. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - May 21, 2012 Category: Dermatology Authors: Beatriz Casado‐Verrier, Rosa Feltes‐Ochoa, Cristina Gómez‐Fernández, Marta Feito‐Rodríguez, María Beato‐Merino, María Luisa Alonso‐Pacheco Tags: Dermatologic surgery Source Type: research

The prognostic value of Ki-67 expression in penile squamous cell carcinoma
Conclusions Ki-67 is only a moderate surrogate marker for HPV infection in PSCC. It does not show prognostic value for cancer-specific survival and overall survival in PSCC. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - May 19, 2012 Category: Pathology Authors: Stankiewicz, E., Ng, M., Cuzick, J., Mesher, D., Watkin, N., Lam, W., Corbishley, C., Berney, D. M. Tags: Immunology (including allergy) Original article Source Type: research

A case of verrucous carcinoma of the esophagus associated with difficult histopathological diagnosis of endoscopic biopsy specimens
Abstract Verrucous carcinoma of the esophagus (VCE) is a rare, slow-growing, well-differentiated squamous cell carcinoma. Histologically, superficial layers of this cancer tend to have less atypical epithelium with non-specific inflammatory change, which therefore makes diagnosis of malignancy extremely difficult unless a surgical specimen is obtained. We recently encountered a case in which a malignant tumor was suspected on initial endoscopic evaluation, but two biopsies revealed no carcinoma cells. Analysis of a third biopsy finally suggested the possibility of squamous cell carcinoma. A subsequent surgic...
Source: Esophagus - May 9, 2012 Category: Gastroenterology Tags: Esophagus Source Type: research

Verrucous carcinoma of the tongue.
Abstract A 75-year-old woman with full dentures had a progressive growth on the tongue for the past 15 years. She reported ulceration of the lesion 4 months prior that was accompanied by pain and odinophagia. She denied addiction to alcohol or tobacco. On examination, there was an ulcerated, vegetating, verrucous lesion, with yellow-whitish areas intermingled with erythematous areas, being infiltrated and having well-defined borders, on almost all areas of the back of the tongue (Figure 1). No adjacent lymphadenopathy was found. Biopsy of the tongue was compatible with verrucous carcinoma demonstrating squamous cel...
Source: Skinmed - May 1, 2012 Category: Dermatology Authors: Vilela FA, Trope BM, Gurfinkel PC, Piñeiro-Maceira JM, Ramos-e-Silva M Tags: Skinmed Source Type: research

Plantar verrucous carcinoma masquerading as toe web intertrigo.
Abstract A 77-year-old man presented with a 6-month history of intractable toe web intertrigo located in the third and fourth web spaces of his left foot. Biopsy and histological examination confirmed the presence of a verrucous carcinoma. Verrucous carcinoma of the foot has been called epithelioma cuniculatum, a case arising in the intertriginous area of the foot is presented. PMID: 22571577 [PubMed - in process] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - May 1, 2012 Category: Dermatology Authors: McKay C, McBride P, Muir J Tags: Australas J Dermatol Source Type: research

Diagnostic problems in precancerous lesions and invasive carcinomas of the penis
Penile precancerous and invasive lesions exhibit a variegated morphology. Although the diagnosis and classification of penile tumors is straightforward in most cases, a few entities are problematic, especially to pathologists from countries in which penile cancer is rarely encountered. The differential diagnosis of squamous hyperplasias from differentiated penile intraepithelial neoplasia or from extremely low-grade invasive neoplasms (eg, pseudohyperplastic and verrucous carcinomas) may be particularly difficult. Similarly, given the morphologic features shared by all verruciform tumors (ie, verrucous, warty, papillary, a...
Source: Seminars in Diagnostic Pathology - April 16, 2012 Category: Pathology Authors: Alcides Chaux, Antonio L. Cubilla Source Type: research

New pathologic entities in penile carcinomas: an update of the 2004 World Health Organization Classification
Most primary malignant tumors of the penis are squamous cell carcinomas (SCC) of the usual type. In recent years several variants, each with distinctive clinicopathologic features, have been described. Pseudohyperplastic carcinoma and carcinoma cuniculatum are both low-grade, extremely well-differentiated SCC variants characterized by an indolent clinical course and good prognosis. The former, which may be confused with pseudoepitheliomatous hyperplasia, preferentially affects the inner foreskin mucosa of elderly men and the latter is a verruciform tumor with an endophytic, burrow-like pattern of growth. Pseudoglandular ca...
Source: Seminars in Diagnostic Pathology - April 16, 2012 Category: Pathology Authors: Alcides Chaux, Elsa F. Velazquez, José E. Barreto, Enrique Ayala, Antonio L. Cubilla Source Type: research

Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva
Abstract: Carcinoma cuniculatum (CC) is a rare variant of low-grade squamous cell carcinoma (SCC), and occurrence in the oral cavity is quite unusual. CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone. Therefore, CC can be quite difficult to remove surgically. A 68-year-old man presented with a case of CC mimicking verrucous leukoplakia in the mandibular gingiva. Repeated biopsies showed no malignancy. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC. Additional hemi...
Source: Auris, Nasus, Larynx - April 14, 2012 Category: ENT & OMF Authors: Jun Suzuki, Sho Hashimoto, Ken-ichi Watanabe, Kaoru Takahashi, Hajime Usubuchi, Hiroyoshi Suzuki Tags: Case reports Source Type: research

Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa
Abstract The aim was to evaluate and compare the presence of myofibroblasts in oral squamous cell carcinoma (OSCC), verrucous carcinoma (VC), high-risk epithelial dysplasia (HRED), low-risk epithelial dysplasia (LRED), and normal oral mucosa (NOM). The study consisted of 37 OSCC, 15 VC, 15 HRED, 15 LRED and 15 NOM. α-smooth muscle actin (α-SMA) antibody was used to identify myofibroblasts. The α-SMA expression was not observed in NOM and LRED. The α-SMA was expressed in 97.29% of OSCC, 86.66% of VC, 46.66 % of HRED. The α-SMA expression was significantly higher in OSCC than VC (p = 0.023) and ...
Source: Head and Neck Pathology - March 6, 2012 Category: Pathology Tags: Head and Neck Pathology Source Type: research

Verrucous carcinoma of the tongue — a rare case study
Abstract Verrucous carcinoma is a slow growing, well demarcated, exophytic variant of squamosus cell carcinoma with a characteristic verrucous presentation. It is a rare tumour and in 75% of cases it is localised in the oral cavity, and sporadically within the tongue. HPV infection is identified in 40% of patients. Good prognosis is characteristic for this tumour, since the 5-year survival is 93%. The authors describe a case of verrucous carcinoma localised in the tongue of a 62-year old patient. The clinical course, diagnostics and proposed treatment was described and discussed with the existing literature ...
Source: Central European Journal of Medicine - January 7, 2012 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: research

Desmosomal proteins and microRNAs—markers for hybrid tumors (verrucous carcinoma with foci of squamous cell carcinoma)
We read with interest the article by Terada , entitled “Verrucous carcinoma of the skin: a report on 5 Japanese cases.” The author reported on pathohistologic and immunohistochemical features in 5 cases of verrucous carcinoma (VC) of the skin. He described the downward infiltrative growth of atypical squamous epithelium at the tumor base in 2 cases of VC, which he termed “microinvasion,” and the coexistence with a focus of less-differentiated conventional squamous cell carcinoma (SCC) in 1 case. He concluded that there is lack of consensus on the nomenclature of the lesions that histologically exhibit features of V...
Source: Annals of Diagnostic Pathology - January 6, 2012 Category: Pathology Authors: Katarina Odar, Nina Gale, Nina Zidar Tags: Letters to the Editor Source Type: research

Spotting Verrucous CarcinomaSpotting Verrucous Carcinoma
A middle-aged woman seeks care for a strange, persistent spot inside her cheek. Medscape Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 29, 2011 Category: Consumer Health News Tags: Dermatology Clinical Case Source Type: news

Carcinoma cuniculatum of foot
We report a case of carcinoma cuniculatum. A 56 years old male presented with lesion on ball of right foot since nine months. Surgically excised specimen revealed ulceroproliferative mass measuring 8cm×6cm×5cm, with everted margins and whitish granular material draining through sinuses at the base of ulcer. Cut surface showed irregular, whitish, firm tumor mass, with tiny cleft like spaces. The mass was compressible and whitish pasty material was extruding from the spaces (). Histopathology revealed tumor with exophytic and endophytic proliferation of well differentiated squamous epithelium with papillomatosis, hyperkera...
Source: The Foot - November 29, 2011 Category: Podiatry Authors: Asha S. Shenoy, Ramesh S. Waghmare, Vikas S. Kavishwar, Gayathri P. Amonkar Tags: Letter to the Editor Source Type: research

Verrucous carcinoma in association with oral submucous fibrosis
C Pravda, H Srinivasan, D Koteeswaran, L Arathy ManoharIndian Journal of Dental Research 2011 22(4):615-615Oral verrucous carcinoma is a form of well differentiated squamous cell carcinoma characterized by exophytic over growth. It is slow growing and locally invasive tumor occurring in 6 th and 7 th decade of life. Smoking and chewing tobacco is found to be the most common etiological factor of verrucous carcinoma although oral leukoplakia may act as a predisposing factor. This is a rare case of oral varrucous Carcinoma seen in association with oral submucous fibrosis in a younger patient with long standing history of che...
Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3) - November 26, 2011 Category: Dentistry Authors: C PravdaH SrinivasanD KoteeswaranL Arathy Manohar Source Type: research

Reconstruction of the complete loss of upper and lower lips with a chimeric anterolateral thigh flap: A case report
We present a case of completely reconstructing the lip defects of a 55‐year‐old patient who had verrucous carcinoma of the buccal mucosa and lips. Extensive ablation was performed by wide bilateral excision of the buccal mucosa and marginal resection of the anterior mandible and both lips. The tongue, partial tongue base mucosa, and retromolar trigone were preserved. To reconstruct and resurface the intraoral and lip defects nearly totally, we applied a free anterolateral thigh (ALT) flap in chimeric style with two independent sets of perforators and skin islands. To achieve better oral function and cosmetics, revision...
Source: Microsurgery - November 24, 2011 Category: Surgery Authors: Chien‐Liang LaiKuang‐Wen OuWen‐Kuan ChiuShyi‐Gen ChenTim‐Mo ChenHsiao‐Ping LiShun‐Cheng Chang Tags: Case Report Source Type: research

Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma
J Oral Pathol Med (2012) 41: 303–308Carcinoma cuniculatum (CC) is a rare neoplasm of oral squamous cell carcinoma (OSCC) and remains a histopathological challenge to pathologists because of its low incidence and unique architecture. Therefore, the purpose of this study was to illustrate the clinicopathological findings and biological behavior about this distinctive lesion. Clinical and follow‐up information were retrieved from medical charts, and histopathological analyses were performed. Our series included 15 cases of CC, and the study included seven men and eight women, age 44–92. The tongue and mandible were the ...
Source: Journal of Oral Pathology and Medicine - November 16, 2011 Category: Pathology Authors: Yan Sun, Kayo Kuyama, Arne Burkhardt, Hirotsugu Yamamoto Source Type: research

Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma
J Oral Pathol Med (2011)Carcinoma cuniculatum (CC) is a rare neoplasm of oral squamous cell carcinoma (OSCC) and remains a histopathological challenge to pathologists because of its low incidence and unique architecture. Therefore, the purpose of this study was to illustrate the clinicopathological findings and biological behavior about this distinctive lesion. Clinical and follow‐up information were retrieved from medical charts, and histopathological analyses were performed. Our series included 15 cases of CC, and the study included seven men and eight women, age 44–92. The tongue and mandible were the most frequentl...
Source: Journal of Oral Pathology and Medicine - November 16, 2011 Category: Pathology Authors: Yan SunKayo KuyamaArne BurkhardtHirotsugu Yamamoto Source Type: research

Excisional biopsy for management of lateral tongue leukoplakia
Conclusion: Leukoplakia of the lateral tongue is highly coexistent with malignancy, and incisional biopsy frequently leads to underdiagnosis. Therefore, complete excision with adequate margin is warranted for leukoplakia of the lateral tongue, preferably under general anesthesia, which could be performed with minimal morbidity and function preservation. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 12, 2011 Category: Pathology Authors: Woo‐Jin Jeong, Jin Ho Paik, Sung‐Woo Cho, Myung‐Whun Sung, Kwang Hyun Kim, Soon‐Hyun Ahn Source Type: research

Lichen Sclerosus and Squamous Cell Carcinoma.
Abstract Lichen sclerosus is a chronic inflammatory disease that can progress to malignancy. The literature indicates an association with anogenital squamous cell carcinoma and verrucous carcinoma. Two pathogenic pathways, differentiated vulvar and penile intraepithelial neoplasias, which have recently been described in relation to squamous cell carcinoma, are both highly associated with genital lichen sclerosus independently of human papilloma virus (HPV) infection. Furthermore, tumor-promoting molecular changes unrelated to HPV infection have been demonstrated and may explain the malignant potential of lichen scl...
Source: Actas Dermo-Sifiliograficas - November 9, 2011 Category: Dermatology Authors: Gutiérrez-Pascual M, Vicente-Martín FJ, López-Estebaranz JL Tags: Actas Dermosifiliogr Source Type: research

Excisional biopsy for management of lateral tongue leukoplakia
Conclusion: Leukoplakia of the lateral tongue is highly coexistent with malignancy, and incisional biopsy frequently leads to underdiagnosis. Therefore, complete excision with adequate margin is warranted for leukoplakia of the lateral tongue, preferably under general anesthesia, which could be performed with minimal morbidity and function preservation. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2011 Category: Pathology Authors: Woo‐Jin JeongJin Ho PaikSung‐Woo ChoMyung‐Whun SungKwang Hyun KimSoon‐Hyun Ahn Source Type: research

Subset of patients with verrucous carcinoma of the oral cavity who benefit from treatment with methotrexate
Abstract: Oral verrucous carcinoma (OVC) is a low-grade variant of squamous cell carcinoma (SCC) with a distinctive morphology and specific pattern of behaviour that is often diagnosed in elderly patients. Resection is the treatment of choice, with radiotherapy as a reasonable alternative. In this retrospective case review we present our experience and outcomes in a group of 12 patients with various stages of OVC who had not been treated conventionally because of the extent of their lesions and their poor general condition. All patients were given chemotherapy with methotrexate, which was given by various routes and in dif...
Source: The British Journal of Oral and Maxillofacial Surgery - October 17, 2011 Category: ENT & OMF Authors: K.H. Karagozoglu, J. Buter, C.R. Leemans, D.H.F. Rietveld, S. van den Vijfeijken, I. van der Waal Tags: CPD Articles Source Type: research

Cutaneous verrucous carcinoma arising in lupus vulgaris
(Source: The Journal of Dermatology)
Source: The Journal of Dermatology - October 4, 2011 Category: Dermatology Authors: Khaled EZZEDINEThierry SIMONARTDenis MALVYClaire BOURGOINJean‐Christophe NOEL Tags: LETTER TO THE EDITOR Source Type: research

Verrucous Carcinoma of the Renal Pelvis with a Focus of Conventional Squamous Cell Carcinoma
Urol Int (DOI:10.1159/000330906) (Source: Urologia Internationalis : Last 20 articles)
Source: Urologia Internationalis : Last 20 articles - September 27, 2011 Category: Urology & Nephrology Source Type: research

[Neurotrophic ulceration following thermocoagulation of the Gasserian ganglion.]
We report a severe case of NTU and describe the main features of this poorly documented disease. OBSERVATION: A 67-year-old female patient consulted in the dermatology department for a progressive ulceration of the nose ala and the right upper lip, having developed over the two previous years. She had undergone two thermocoagulations of the right Gasserian ganglion for facial neuralgia 3 years before. The diagnosis of NTU, initially ruled out because of biopsies suggesting verrucous carcinoma, was finally retained because of the clinical presentation and anamnesis. Treatment consisted in surgical excision and primary recon...
Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale - September 27, 2011 Category: ENT & OMF Authors: Lamoureux M, Bonnot P, Schmidt-Guerre AR, Humbert P, Algros MP, Meyer C Tags: Rev Stomatol Chir Maxillofac Source Type: research

Verrucous carcinoma of the hand: a rare presentation evaluated by magnetic resonance imaging
O carcinoma verrucoso é uma variante do carcinoma de células escamosas, vista em mucosas e pele, raramente encontrada na mão. Nós relatamos um caso de duas lesões no dorso da mão, sem contato entre si, que foram ressecadas em bloco e confirmadas como carcinoma verrucoso.Verrucous carcinoma is a variant of squamous cell carcinoma seen in mucous membranes and skin, and rarely found in the hand. The present report describes a case of two lesions on the dorsum of the hand, with no contact to each other, which underwent en-block resection and were confirmed as verrucous carcinoma. (Source: Radiologia Brasileira)
Source: Radiologia Brasileira - September 13, 2011 Category: Radiology Source Type: research