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The Impact of Trimetazidine on Cardiac Fibrosis, Inflammation, and Function in Ischemic Cardiomyopathy Patients
ConclusionAdjunctive TMZ therapy for ICM effectively improved vascular endothelial function and reduced inflammation. Furthermore, our exploratory findings may be used to provide new information on the potential effects of TMZ on myocardial fibrosis by downregulating CTGF.
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
Functional Characterization of Two Efficient Glycosyltransferases Catalysing the Formation of Rutin from Sophora japonica L.
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01281F, CommunicationJianlin Zou, Hongye Li, Zilong Wang, Min Ye Two efficient and selective glycosyltransferases were identified from Sophora japonica L. Sj3GT could regio-selectively catalyse 3-O-glucosylation of quercetin to produce isoquercitrin, and Sj6''RhaT could further catalyse its 6''-O-rhamnosylation to generate... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 22, 2023 Category: Molecular Biology Authors: Jianlin Zou Source Type: research
Multicomponent cyclization with azides to synthesize N-heterocycles
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01115A, Review ArticleHong Guo, Bei Zhou, Jingjing Chang, Wenxu Chang, Jiyao Feng, Zhenhua Zhang Heterocyclic compounds, both naturally derived and synthetically produced, constitute a wide variety of biologically active and industrially important compounds. The synthesis and application of heterocyclic compounds have garnered significant attention... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 22, 2023 Category: Molecular Biology Authors: Hong Guo Source Type: research
Pd@GO catalyzed stereo- and regio-selective addition of arenes to alkynes and synthesis of coumarins via C-H functionalization
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01237A, PaperLenida Kyndiah, Fillip Kumar Sarkar, Sushmita Gajurel, Rajib Sarkar, Jasha Momo H. Anal, Amarta Kumar Pal A stereo- and regio-selective addition of arenes to alkynes via C-H bond functionalization has been developed using palladium nanoparticles supported on graphite oxide (Pd@GO) as the reusable catalyst. The prepared... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 22, 2023 Category: Molecular Biology Authors: Lenida Kyndiah Source Type: research
Improve emission performance of benzoaphenoxazine in aqueous solution through Host-Guest interaction
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01427D, CommunicationShu-Yi Li, Wenli Wang, Chang Wang, Ru Sun, Jian-Feng Ge To evaluate the contribution of Host-Guest chemistry in fluorescent enhancement under aqueous condition, two benzo[a]phenoxazine derivatives with adamantyl group were prepared. After they formed stable complexes with methyl- β-cyclodextrin, their emissions... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 22, 2023 Category: Molecular Biology Authors: Shu-Yi Li Source Type: research
Many Americans Frustrated in Search for Low-Cost COVID Boosters
FRIDAY, Sept. 22, 2023 -- Americans seeking out the new COVID boosters are finding themselves held back by insurance entanglements and supply delays.
Some insurers have balked at covering the vaccines, with people arriving at shot appointments only...
Source: Drugs.com - Daily MedNews - September 22, 2023 Category: General Medicine Source Type: news
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy
Conditions: Cognitive Impairment; Cognitive Decline; Radiotherapy Side Effect; Radiotherapy; Complications; Brain Tumor; Memory Impairment; Late Effect of Radiation Interventions: Drug: Lithium; Drug: Placebo Sponsors: Region Stockholm; Rigshospitalet, Denmark Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
A Pilot Study of Circulating Tumor DNA Adaptive Risk Maintenance Approach for Bladder Cancer (CARMA)
Condition: Metastatic Urothelial Carcinoma Interventions: Drug: Pembrolizumab (200mg); Drug: Pembrolizumab (400mg); Diagnostic Test: Monitoring Sponsor: Fox Chase Cancer Center Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
CRACK-TARGET 1: ÉTUDE DESCRIPTIVE DE LA SENSIBILISATION COMPORTEMENTALE OBSERVÉE et ATTENTES
Condition: Cocaine Use Disorder Interventions: Behavioral: Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter; Biological: 3 blood tests Sponsors: Assistance Publique - Hôpitaux de Paris; Institut National de la Santé Et de la Recherche Médicale, France Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy
Conditions: Adrenal Tumor; Adrenal Disease; Adrenal Mass; Adrenalectomy; Status; Adrenal Hyperplasia; Adrenal Gland Metastasis; Adrenal Cortex Diseases; Pheochromocytoma; Cushing Syndrome; Conn Adenoma; Adrenocortical Carcinoma; Adrenocortical Adenoma; Adreno cortical Tumor Intervention: Sponsors: University Hospital Olomouc; University Hospital Ostrava; Tomas Bata Hospital, Czech Republic; General University Hospital, Prague; University Hospital Hradec Kralove Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy
Conditions: Cognitive Impairment; Cognitive Decline; Radiotherapy Side Effect; Radiotherapy; Complications; Brain Tumor; Memory Impairment; Late Effect of Radiation Interventions: Drug: Lithium; Drug: Placebo Sponsors: Region Stockholm; Rigshospitalet, Denmark Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
A Pilot Study of Circulating Tumor DNA Adaptive Risk Maintenance Approach for Bladder Cancer (CARMA)
Condition: Metastatic Urothelial Carcinoma Interventions: Drug: Pembrolizumab (200mg); Drug: Pembrolizumab (400mg); Diagnostic Test: Monitoring Sponsor: Fox Chase Cancer Center Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Combining CEM and Magnetic Seed Localization of Non-Palpable Breast Tumors
Condition: Breast Cancer Intervention: Device: Pintuition Sponsor: Zuyderland Medisch Centrum Active, not recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Tumor Microenvironment Mechanism of LY007 for r/r B-NHL and the Exploration of Novel CAR-T Translational Research
Condition: Relapsed Non-Hodgkin Lymphoma Intervention: Sponsor: Ruijin Hospital Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
MK-2870 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)
Conditions: Non-small Cell Lung Cancer; Solid Tumors; Programmed Cell Death-1 (PD1, PD-1); Programmed Cell Death 1 Ligand 1(PDL1, PD-L1); Programmed Cell Death 1 Ligand 2 (PDL2, PD-L2) Interventions: Biological: MK-2870; Biological: Pembrolizumab; Drug: Carboplatin Sponsor: Merck Sharp & Dohme LLC Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
