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Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kinase activity is known as the key biochemical property of MAPKs. Here, we report that ERK1/2 also utilizes its noncatalytic function to mediate certain signal transductions. Sustained activation of the Raf/MEK/ERK pathway induces growth arrest, accompanied by changes in cell cycle regulators (decreased retinoblastoma phosphorylation, E2F1 down-regulation, and/or p21CIP1 up-regulation) and cell type-specific changes in morphology and expression of c-Myc or RET in the human tumor lines LNCaP, U251, and TT. Ablation of ERK1/2 by RNA interference abrogated all these effects. However, active site-disabled ERK mutants (ERK1-K7...
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Hong, S.-K., Yoon, S., Moelling, C., Arthan, D., Park, J.-I. Tags: Mechanisms Of Signal Transduction Source Type: journals

SPECT/CT for preoperative sentinel node localizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The value of SPECT/CT for detection and localization of sentinel nodes is reviewed. SPECT/CT depicts extra sentinel nodes and identifies non-nodal tracer accumulation. SPECT/CT is indicated in patients with complex lymphatic drainage as often present in patients with head, neck and scapular melanoma, breast cancer patients with extra-axillary sentinel nodes and patients with tumors draining to pelvic nodes. SPECT/CT also clarifies the drainage pattern of inconclusive conventional images (non-visualization or unclear location of the nodes). J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - November 19, 2009 Category: Cancer & Oncology Authors: Lenka Vermeeren, iris M.C. van der Ploeg, Renato A. Valdés Olmos, Willem Meinhardt, W. Martin C. Klop, Bin B.R. Kroon, Omgo E. Nieweg Source Type: journals

Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cyclooxygenase-2 is constitutively expressed in normal human eyes. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells. (Source: Acta Ophthalmologica)
Source: Acta Ophthalmologica - November 19, 2009 Category: Opthalmology Authors: Jinmei Wang, Yazhen Wu, Steffen Heegaard, Miriam Kolko Source Type: journals

Axenfeld-Rieger ocular anomaly and retinoblastoma caused by constitutional chromosome 13q deletionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 2-month-old female with general development delay and dysmorphic features. AR anomaly was detected, and a retinoblastoma (RB) was diagnosed in a very early stage. De novo 13q deletion was identified. Systemic chemotherapy, focal cryotherapy, transpupillary thermotherapy, brachytherapy, and intra-arterial chemotherapy were needed to control the RB. This is the first report of an association of AR, 13q deletion, and retinoblastoma, to be disclosed in patients born with such ocular and dysmorphic features. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Ana Roche, Jaume Mora, Maria del Mar Perez, Esther Gean, Belen Perez, Mar O'Callaghan, Jaume Catala, Carmen De Torres, Ofelia Cruz, Joan Prat, Andreu Parareda Source Type: journals

Remission of extensive intrahepatic metastasis by C-arm computed tomography guided chemoembolization in uveal melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As soon as uveal melanoma has metastasized to the liver, response rates to systemic chemotherapy are low. It can be improved by development of special locoregional procedures. A 24-year-old woman suffered from inoperable hepatic metastases which grew to life-endangering size despite both systemic chemotherapy with gemc-itabine/treosulfan and conventional intrahepatic chemoembolization with fotemustine and starch particles. We subsequently performed two angiographic C-arm CT-guided, superselective chemoembolizations of the hepatic arteries feeding the tumor, using cisplatin, starch microspheres and ethiodized oil. Following...
Source: JDDG - November 18, 2009 Category: Dermatology Authors: Cord Sunderkötter, Mareike Eickelmann, Michael Köhler, Alexander Schmittel, Frank K. Wacker Source Type: journals

Anti-proliferative effects of γ-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: Previous studies have shown that [gamma]-tocotrienol induces potent anti-proliferative effects on +SA mammary tumour cells in culture; here, investigations have been conducted to determine its effects on intracellular signalling proteins involved in regulating cell cycle progression.Materials and methods: +SA cells were maintained in mitogen-free defined media containing 0 or 4 [mu]m[gamma]-tocotrienol, for 48 h to synchronize cell cycle in G0 phase, and then they were exposed to 100 ng/ml EGF to initiate cell cycle progression. Whole cell lysates were collected at various time points from each treatment group ...
Source: Cell Proliferation - November 17, 2009 Category: Cytology Authors: G. V. Samant, V. B. Wali, P. W. Sylvester Source Type: journals

Incidence of retinoblastoma in Dutch children conceived by IVF: an expanded studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS We found a significantly increased risk of retinoblastoma in children conceived by IVF in the total study period 1995–2007. However, this increased risk was mostly based on the much stronger risk increase observed previously, for 1995–2002. Caution and awareness on the one hand and avoiding unnecessary worries on the other hand are important at this stage of our knowledge. (Source: Human Reproduction)
Source: Human Reproduction - November 16, 2009 Category: Reproduction Medicine Authors: Marees, T., Dommering, C.J., Imhof, S.M., Kors, W.A., Ringens, P.J., van Leeuwen, F.E., Moll, A.C. Tags: Reproductive epidemiology Source Type: journals

Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The differences in the expression of cyclin D1 and retinoblastoma may indicate the differences in the pathogenesis of PDV and PDB. (Source: Histopathology)
Source: Histopathology - November 16, 2009 Category: Pathology Authors: Patricia E Ellis, Allan B MacLean, Julie C Crow, L F Wong Te Fong, Kerstin J Rolfe, Christopher W Perrett Source Type: journals

Depression and quality of life during treatment of ocular bulb removal in individuals with uveal melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to asses the emotional repercussions in individuals with uveal melanoma referred for surgery, during the diagnosis and preoperative, post-surgery and late post-surgery phases. The clinical qualitative assessment used the Beck Depression Inventory and the Medical Outcomes Study 36-Item Short-Form Health Survey. Twenty patients were individually assessed, 13 men and 7 women, with an average age of 52. Before surgery, patients appeared fragile and impacted by the diagnosis and treatment, showing a minimum to mild state of depression and a quality of life affected by emotional and physical concep...
Source: European Journal of Cancer Care - November 13, 2009 Category: Cancer & Oncology Authors: T.A.C. AMARO, L. YAZIGI, C. ERWENNE Source Type: journals

Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-AktEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Paclitaxel (PTX) and beta-lapachone (LPC) are naturally occurring compounds that have shown a large spectrum of anticancer activity. In this article we show for the first time that PTX/LPC combination induces potent synergistic apoptotic effects in human retinoblastoma Y79 cells. Combination of suboptimal doses of PTX (0.3 nM) and LPC (1.5 µM) caused biochemical and morphological signs of apoptosis at 48 h of treatment. These effects were accompanied by potent lowering in inhibitor of apoptosis proteins and by activation of Bid and caspases 3 and 6 with lamin B and PARP breakdown. PTX/LPC combination acted by favoring p53...
Source: Journal of Cellular Physiology - November 13, 2009 Category: Cytology Authors: Antonella D'Anneo, Giuseppa Augello, Andrea Santulli, Michela Giuliano, Riccardo di Fiore, Concetta Messina, Giovanni Tesoriere, Renza Vento Source Type: journals

p27Kip1 Stabilization Is Essential for the Maintenance of Cell Cycle Arrest in Response to DNA DamageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the current models of cancer proposes that oncogenes activate a DNA damage response (DDR), which would limit the growth of the tumor in its earliest stages. In this context, and in contrast to studies focused on the acute responses to a one-time genotoxic insult, understanding how cells respond to a persistent source of DNA damage might become critical for future studies in the field. We here report the discovery of a novel damage-responsive pathway, which involves p27Kip1 and retinoblastoma tumor suppressors and is only implemented after a persistent exposure to clastogens. In agreement with its late activation, we...
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Authors: Cuadrado, M., Gutierrez-Martinez, P., Swat, A., Nebreda, A. R., Fernandez-Capetillo, O. Tags: Molecular Biology, Pathobiology, and Genetics Source Type: journals

Retinoblastoma Family Proteins Have Distinct Functions in Pulmonary Epithelial Cells In vivo Critical for Suppressing Cell Growth and TumorigenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lung cancer is the leading cause of cancer deaths, accounting for more deaths than breast, colon, and prostate cancer combined. The retinoblastoma (Rb)/p16 tumor suppressive pathway is deregulated in most cancers. Loss of p16 occurs more frequently than Rb loss, suggesting that p16 suppresses cancer by regulating Rb as well as the related proteins p107 and p130. However, direct evidence demonstrating that p130 or p107 cooperate with Rb to suppress epithelial cancers associated with p16 loss is currently lacking. Moreover, the roles of p130 and p107 in lung cancer are not clear. In the present studies, Rb ablation was targe...
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Authors: Simpson, D. S., Mason-Richie, N. A., Gettler, C. A., Wikenheiser-Brokamp, K. A. Tags: Molecular Biology, Pathobiology, and Genetics Source Type: journals

Dormancy of metastatic melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metastatic dormancy of melanoma has not received sufficient attention, most likely because once detectable, metastasis is almost invariably fatal and, understandably, the focus has been on finding ways to prolong life of patients with overt recurrences. Nevertheless, analysis of the published clinical and experimental data on melanoma indicates that some aspect of melanoma biology imitate traits recently associated with dormancy in other solid cancers. Among them the ability of some melanomas to disseminate early during primary tumor progression and once disseminated, to remain undetected (dormant) for years. Comparison of...
Source: Pigment Cell Research - November 11, 2009 Category: Cytology Authors: Liliana Ossowski, Julio A. Aguirre-Ghiso Source Type: journals

Trilateral retinoblastoma: Potentially curable with intensive chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a series of 13 patients treated with intensive chemotherapy, defined as the intention to include high-dose chemotherapy with autologous hematopoietic stem cell rescue.Induction chemotherapy generally included vincristine, cisplatin or carboplatin, cyclophosphamide, and etoposide. Hematopoietic stem cells typically were harvested after the first or second cycle of induction chemotherapy, usually from peripheral blood. High-dose chemotherapy regimens were thiotepa-based (n = 7) or melphalan and cyclophosphamide (n = 3).Trilateral sites were pineal (n = 11) and suprasellar (n = 2); 7 patients had localized (M-0) d...
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Ira J. Dunkel, Rima F. Jubran, Sri Gururangan, Guillermo L. Chantada, Jonathan L. Finlay, Stewart Goldman, Yasmin Khakoo, Joan M. O'Brien, Manuela Orjuela, Carlos Rodriguez-Galindo, Mark M. Souweidane, David H. Abramson Source Type: journals

Long-Term Safety of Recombinant Human Growth Hormone in Children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: After more than 20 yr, leukemia, a major safety issue initially believed associated with GH, has not been confirmed, but other signals, including risk of second malignancies in patients previously treated with irradiation, have been detected or confirmed through the NCGS. These data further clarify the events associated with rhGH and, although confirming a favorable overall safety profile, they also highlight specific populations at potential risk. PMID: 19906787 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Bell J, Parker KL, Swinford RD, Hoffman AR, Maneatis T, Lippe B Tags: J Clin Endocrinol Metab Source Type: journals

Detection of survivin protein in aqueous humor and serum of retinoblastoma patients and its clinical significance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Measurement of survivin protein might have a great diagnostic and prognostic potential in retinoblastoma. PMID: 19913527 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 11, 2009 Category: Biochemistry Authors: Shehata HH, Abou Ghalia AH, Elsayed EK, Ziko OO, Mohamed SS Tags: Clin Biochem Source Type: journals

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ataxia telangiectasia mutated (ATM) and the ATM- related (ATR) kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens. The components of the ATM and ATR regulated signaling pathways thus provide attractive pharmacological targets, since their inhibition enhances cellular sensitivity to chemo- and radiotherapy. Caffeine as well as more specific inhibitors of ATM (KU55933) or ATM and ATR (CGK733) have recently been shown to induce cell death in drug-induced senescent tumor cells. Addition of these agents to cancer cells previously rendered senescent by exposure to genot...
Source: Radiation Oncology - November 10, 2009 Category: Cancer & Oncology Authors: John AlaoPer Sunnerhagen Source Type: journals

Risk of Cataract Extraction Among Adult Retinoblastoma Survivors [Epidemiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The results emphasize the importance of ophthalmologic examination of retinoblastoma survivors who have undergone radiotherapy. The risk of cataract extraction in untreated eyes with retinoblastoma is comparable with the risk of the general population. (Source: Archives of Opthalmology)
Source: Archives of Opthalmology - November 9, 2009 Category: Opthalmology Authors: Chodick, G., Kleinerman, R. A., Stovall, M., Abramson, D. H., Seddon, J. M., Smith, S. A., Tucker, M. A. Tags: Oncology, Oncology, Other, Ophthalmology, Ophthalmological Disorders, Cataracts/ Lens, Ocular/ Adnexal Tumors, Retinal/ Chorioretinal Disorders, Retinal Detachment, Ophthalmological Procedures, Vitreoretinal Surgery, Ophthalmological Procedures, Other, Ra Source Type: journals

Immunohistochemical assessment of mitotic count in uveal melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: MF were more easily identified following immunohistochemical staining with anti-PHH3. This resulted in higher mitotic counts than obtained with H&E sections. For PHH3, the mitotic count determined by a MA was virtually the same as those obtained by an experienced pathologist. PHH3 is now routinely used in our centre, and new prognostic thresholds for uveal melanoma will be defined in further studies. (Source: Acta Ophthalmologica)
Source: Acta Ophthalmologica - November 9, 2009 Category: Opthalmology Authors: Martina Angi, Bertil Damato, Helen Kalirai, Andrew Dodson, Azzam Taktak, Sarah E. Coupland Source Type: journals

Surgical Management of Liver Metastases From Uveal Melanoma: 16 Years' Experience at the Institut CurieEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
R0 surgical resection almost doubled survival, to 27 months, in this single-institution experience. Background: Uveal melanoma is characterised by a high prevalence of liver metastases and a poor prognosis. Aim:... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - November 5, 2009 Category: Cancer & Oncology Source Type: journals

pRb loss predicts good outcome in triple negative breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Loss of expression of the retinoblastoma protein is more common in triple-negative breast cancers than in othersubtypes, and is associated with a better outcome after chemotherapy compared with cancers expressing pRb, Italian researchers report. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - November 5, 2009 Category: Cancer & Oncology Source Type: news

pRb loss predicts good outcome in triple negative breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Loss of expression of the retinoblastoma protein is more common in triple-negative breast cancers than in othersubtypes, and is associated with a better outcome after chemotherapy compared with cancers expressing pRb, Italian researchers report. (Source: MedWire News - Breast Cancer)
Source: MedWire News - Breast Cancer - November 4, 2009 Category: Cancer & Oncology Source Type: news

Retinoblastoma Family Proteins Have Distinct Functions in Pulmonary Epithelial Cells In vivo Critical for Suppressing Cell Growth and Tumorigenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lung cancer is the leading cause of cancer deaths, accounting for more deaths than breast, colon, and prostate cancer combined. The retinoblastoma (Rb)/p16 tumor suppressive pathway is deregulated in most cancers. Loss of p16 occurs more frequently than Rb loss, suggesting that p16 suppresses cancer by regulating Rb as well as the related proteins p107 and p130. However, direct evidence demonstrating that p130 or p107 cooperate with Rb to suppress epithelial cancers associated with p16 loss is currently lacking. Moreover, the roles of p130 and p107 in lung cancer are not clear. In the present studies, Rb ablation was t...
Source: Cell Research - November 3, 2009 Category: Cytology Authors: Simpson DS, Mason-Richie NA, Gettler CA, Wikenheiser-Brokamp KA Tags: Cancer Res Source Type: journals

PI3K/Akt Pathway Mutations in Retinoblastoma [Anatomy and Pathology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A somatic mutation in the AKT1 gene (E17K) was identified recently in human tumors. The authors found that oncogenic E17K AKT1 mutations are rare in retinoblastoma. Although the PI3K-AKT pathway is dysregulated in retinoblastoma, the low frequency of oncogenic mutations in the AKT1, PIK3CA, and PTEN genes suggests a different activating mechanism. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Cohen, Y., Merhavi-Shoham, E., Avraham-Lubin, B. C. R., Savetsky, M., Frenkel, S., Pe'er, J., Goldenberg-Cohen, N. Tags: Anatomy and Pathology Source Type: journals

RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Here we show for the first time that RB acute loss triggers centrosome amplification and aneuploidy in human primary fibroblasts. Altogether, our results suggest that pRb depleted primary human fibroblasts possess an intact spindle checkpoint and that micronuclei, likely caused by mis-attached kinetochores that in turn trigger chromosome segregation errors, are responsible for aneuploidy in primary human fibroblasts where pRb is acutely depleted. (Source: BioMed Central)
Source: BioMed Central - November 2, 2009 Category: Journals (General) Authors: Angela AmatoLaura LentiniTiziana SchillaciFlora IovinoAldo Di Leonardo Source Type: journals

Development of a soluble PTD-HPV18E7 fusion protein and its functional characterization in eukaryotic cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Though accumulated evidence has demonstrated the transformation capacity of human papillomavirus (HPV) type 18 protein E7, the underlying mechanism is still arguable. Developing a protein transduction domain (PTD)-linked E7 molecule is a suitable strategy for assessing the biological functions of the protein. In the present study, HPV18 E7 protein fused to an N-terminal PTD was expressed in the form of glutathione S-transferase fusion protein in Escherichia coli with pGEX-4T- 3 vector. After glutathione-Sepharose 4B bead affinity purification, immunoblot identification and thrombin cleavage, the PTD-18E7 protein showed...
Source: Acta Biochimica et Biophysica Sinica - November 1, 2009 Category: Biochemistry Authors: Yan X, Walayat S, Shi Q, Zheng J, Wang Y Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: journals

Radiation-induced spindle cell sarcoma: A rare case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Khan Mubeen, Chandramala Rupa, Sharma Ridhima, Vijayalakshmi K RIndian Journal of Dental Research 2009 20(3):380-384Ionizing radiation has been known to induce malignant transformation in human beings. Radiation-induced sarcomas are a late sequel of radiation therapy. Most sarcomas have been reported to occur after exposure to a radiation dose of 55 Gray (Gy) and above, with a dose ranging from 16 to 112 Gys. Spindle cell sarcomas, arising after radiotherapy given to treat the carcinoma of head and neck region is a very uncommon sequel. This is a rare case report of spindle cell sarcoma of left maxilla, in a 24-year-old ma...
Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3) - October 31, 2009 Category: Dentistry Authors: Khan Mubeen, Chandramala Rupa, Sharma Ridhima, Vijayalakshmi K R Source Type: journals

Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The prognosis for patients with synchronous and metachronous skeletal osteosarcoma is poor. However, because long-term survival is seen, aggressive treatment to selected cases, e.g., patients with an osteosarcoma predisposing syndrome and/or late occurring metachronous tumours, is justified. Revealing a possible clonal relationship between these tumors, e.g., by karyotyping, may be of interest for estimating prognosis and guide therapy intensiveness. PMID: 19863225 [PubMed - in process] (Source: Acta Oncologica)
Source: Acta Oncologica - October 31, 2009 Category: Cancer & Oncology Authors: Brandal P, Bjerkehagen B, Bruland OS, Skjeldal S, Bogsrud TV, Hall KS Tags: Acta Oncol Source Type: journals

A reappraisal of the significance of largest basal diameter of posterior uveal melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
mp; S E Coupland (Source: Eye)
Source: Eye - October 30, 2009 Category: Opthalmology Authors: B DamatoS E Coupland Source Type: journals

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These studies suggest a role for CDK4/6 inhibition in some breast cancers and identify criteria for patient selection in clinical studies of PD 0332991. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Richard FinnJudy DeringDylan ConklinOndrej KalousDavid CohenAmrita DesaiCharles GintherMohammad AtefiIsan ChenCamilla FowstGerret LosDennis Slamon Source Type: journals

Retinoblastoma 1 Protein Modulates XY Germ Cell Entry into G1/G0 Arrest During Fetal Development in Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During mouse germ cell development, the first sign of sex differentiation occurs when XY germ cells enter G1/G0 arrest from 12.5 days postcoitum (dpc). Retinoblastoma 1 (RB1), a potent cell cycle regulator, was investigated in XY germ cell arrest by studying germ cell proliferation in Rb1(-/-) mutant mouse embryos. As mice homozygous for the Rb1 deletion die in utero around 14.5 dpc, we used ex vivo culture techniques to allow analysis of developing gonads to 16.5 dpc. In Rb1(-/-) gonads, we observed normal somatic cell development, assessed by immunofluorescence for markers HSD3B1 and AMH. However, at 14.5 dpc, when w...
Source: Biology of Reproduction - October 28, 2009 Category: Reproduction Medicine Authors: Spiller CM, Wilhelm D, Koopman P Tags: Biol Reprod Source Type: journals

High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: pRb loss is much more frequent in TNBCs than in the other breast cancer subtypes. Patients with TNBCs lacking pRb had a very favorable clinical outcome if treated with conventional adjuvant chemotherapy. (Source: Annals of Oncology)
Source: Annals of Oncology - October 27, 2009 Category: Cancer & Oncology Authors: Trere, D., Brighenti, E., Donati, G., Ceccarelli, C., Santini, D., Taffurelli, M., Montanaro, L., Derenzini, M. Tags: breast cancer Source Type: journals

Retinoblastoma and the Genetic Theory of Cancer: An Old Paradigm Trying to Survive to the EvidenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Retinoblastoma (Rb) is considered to represent the prototype of cancer linked to the sequential loss or inactivation of both alleles of a so-called “tumor suppressor gene”, the Rb1 gene. The pathogenetic mechanism behind this tumor was first hypothesized by Knudson in 1971 and further confirmed by others who identified the Rb1 gene whose loss or inactivation was claimed to be responsible for the disease. However, after about four decades of continuous research in the field of molecular biology, the evidence behind the role of the Rb1 gene in Rb appears to be seriously flawed in the light of epidemiological, bio...
Source: Journal of Cancer Epidemiology - October 27, 2009 Category: Epidemiology Source Type: journals

Investigation of the miR16-1 (C>T) + 7 Substitution in Seven Different Types of Cancer from Three Ethnic GroupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Considering the large scale of our study, the representation of different ethnicities and levels of hereditary risk, we conclude that the miR-16-1 (C>T) + 7 mutation is not a good diagnostic or prognostic indicator of risk for the cancers tested. (Source: Journal of Oncology)
Source: Journal of Oncology - October 26, 2009 Category: Cancer & Oncology Source Type: journals

Emerging roles of E2Fs in cancer: an exit from cell cycle controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
vo Leone Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating the RB pathway have been identified in almost every human malignancy. The E2F transcription factors function in cell cycle control and are intimately regulated by RB. Studies of model organisms have revealed (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 23, 2009 Category: Cancer & Oncology Authors: Hui-Zi ChenShih-Yin TsaiGustavo Leone Tags: Review Source Type: journals

Dormancy of metastatic melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Metastatic dormancy of melanoma has not received sufficient attention, most likely because once detectable, metastasis is almost invariably fatal and, understandably, the focus has been on finding ways to prolong life of patients with overt recurrences. Nevertheless, analysis of the published clinical and experimental data on melanoma indicates that some aspect of melanoma biology imitate traits recently associated with dormancy in other solid cancers. Among them the ability of some melanomas to disseminate early during primary tumor progression and once disseminated, to remain undetected (dormant) for years. ...
Source: Pigment Cell and Melanoma Research - October 18, 2009 Category: Cytology Authors: Ossowski L, Aguirre-Ghiso JA Tags: Pigment Cell melanoma Res Source Type: journals

Surgical management of liver metastases from uveal melanoma: 16 years' experience at the Institut CurieEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Surgical resection, when possible, is able to almost double the survival and appears at present the optimal way of improving the prognosis in metastatic uveal melanoma. Advances in medical treatments will be required to further improve survival. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: P. Mariani, S. Piperno-Neumann, V. Servois, M.G. Berry, T. Dorval, C. Plancher, J. Couturier, C. Levy-Gabriel, L. Lumbroso-Le Rouic, L. Desjardins, R.J. Salmon Tags: Original Articles Source Type: journals

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human mesenchymal stem cells (hMSC) are critical for tissue regeneration. How hMSC respond to genotoxic stresses and potentially contribute to aging and cancer remain underexplored. We showed that ionizing radiation induced cellular senescence of hMSC over a period of 10 days, showing a critical transition between days 3 and 6. This was confirmed by senescence-associated β-galactosidase staining, protein expression profiles of key cell cycle regulators (retinoblastoma protein, p53, p21waf1/Cip1, and p16INK4A), and senescence-associated secretory phenotypes (interleukin-8, interleukin-12, GRO, and MDC). We observed dra...
Source: Cancer Research - October 15, 2009 Category: Cancer & Oncology Authors: Wang, D., Jang, D.-J. Tags: Systems Biology and Emerging Technologies Source Type: journals

Bioluminescence Imaging Used For Eye Cancer DetectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At the moment, doctors rely on biopsy analysis to determine the progression of eye cancer. However, researchers now believe that a new technology, bioluminescence imaging, will allow doctors to detect tumors earlier and quickly choose a method of treatment that doesn't necessarily involve eye surgery. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 14, 2009 Category: Science Source Type: news

Bioluminescence Imaging Used For Eye Cancer DetectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At the moment, doctors rely on biopsy analysis to determine the progression of eye cancer. However, researchers now believe that a new technology, bioluminescence imaging (BLI), will allow doctors to detect tumors earlier and quickly choose a method of treatment that doesn't necessarily involve eye surgery. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 14, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Expression profiling of formalin-fixed paraffin embedded primary human uveal melanomas using DASL matricesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions To the best of our knowledge, this is the first time that a successful retrospective analysis has been done with UM FFPE RNA. This data may lead to future customized therapeutic targets, which may improve the now unchanged mortality rate of this particular malignancy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0692-3Authors Sebastian Di Cesare, McGill University Health Center The Henry C. Witelson Ophthalmic Pathology Laboratory and Registry 3775 University St., Lyman Duff Building, Room 216 Montreal QC H3A 2B4 CanadaAndre Nantel, National Research Council of...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions/interpretation Underproduction of IRBP is an early event in the human diabetic retina and is associated with retinal neurodegeneration. The mechanisms leading to this deficit deserve further investigation. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1548-8Authors M. Garcia-Ramírez, Institut de Recerca Hospital Universitari Vall d’Hebron CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM), Diabetes and Metabolism Research Unit Universitat Autònoma de Barcelona Pg. Vall d’Hebron 119-129 08035 Barcelona SpainC. Hernández, Institut de Recerca Hospital U...
Source: Diabetologia - October 13, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals

Bioluminescence imaging used for eye cancer detectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Association for Research in Vision and Ophthalmology) At the moment, doctors rely on biopsy analysis to determine the progression of eye cancer. However, researchers now believe that a new technology, bioluminescence imaging, will allow doctors to detect tumors earlier and quickly choose a method of treatment that doesn't necessarily involve eye surgery. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 13, 2009 Category: Global & Universal Source Type: news

Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: AZD5438 was generally well tolerated in a weekly dosing schedule, but not in continuous schedules. The clinical development programme for AZD5438 was discontinued owing to tolerability and exposure data from these studies. PMID: 19825886 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 12, 2009 Category: Cancer & Oncology Authors: Boss DS, Schwartz GK, Middleton MR, Amakye DD, Swaisland H, Midgley RS, Ranson M, Danson S, Calvert H, Plummer R, Morris C, Carvajal RD, Chirieac LR, Schellens JH, Shapiro GI Tags: Ann Oncol Source Type: journals

Fourier Domain Optical Coherence Tomographic and Auto-Fluorescence Findings inChoroidal Melanocytic Lesions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: FD OCT and FAF compliment clinical examination by verifying and documenting retinal and RPE changes associated with indeterminate choroidal melanocytic lesions. The detection rates by FD OCT and FAF of important qualitative prognostic factors appear to be equivalent to ophthalmoscopy by a trained observer. Once validated in a larger number of patients, FD OCT and FAF findings can be incorporated into diagnostic algorithms. PMID: 19822920 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - October 11, 2009 Category: Opthalmology Authors: Singh AD, Belfort RN, Sayanagi K, Kaiser PK Tags: Br J Ophthalmol Source Type: journals

Thirty months prospective study on the treatment of retinoblastoma in Gabriel Toure Bamako Mali: 55 cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The mortality associated to Retinoblastoma remains high in our regions because diagnosis is always late and it is difficult to follow-up the patients. Education and raising the awareness of both population and health workers would improve the survival rate of patients with retinoblastoma in Africa. PMID: 19822911 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - October 11, 2009 Category: Opthalmology Authors: Togo B, Sylla F, Traoré F, Sylla M, Dicko-Traoré F, Sidibé T, Diakité AA, Keïta MM Tags: Br J Ophthalmol Source Type: journals

Change of Choroidal Nevi during Five Years Follow-Up. The Beijing Eye Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Adult Chinese with an age of 40+ years show an enlargement of presumed choroidal nevi in only a small percentage of subjects during a follow-up of 5 years. Taking into consideration that most of the study participants were already past the age of the highest risk of developing a uveal melanoma in Chinese, the results may suggest a low risk of growth of choroidal nevi into malignant choroidal melanomas in Chinese. PMID: 19822910 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - October 11, 2009 Category: Opthalmology Authors: You QS, Xu L, Jonas JB, Wang S, Yang H Tags: Br J Ophthalmol Source Type: journals

Is CT Still Useful in the Study Protocol of Retinoblastoma? [HEAD AND NECK]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A combination of clinical data and MR images may remove potentially harmful ionizing radiation from the study protocol of retinoblastoma. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - October 8, 2009 Category: Radiology Authors: Galluzzi, P., Hadjistilianou, T., Cerase, A., De Francesco, S., Toti, P., Venturi, C. Tags: HEAD AND NECK Source Type: journals

Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study is the first to identify GILZ as a molecule produced by ovarian cancer cells that promotes cell cycle progression and proliferation. Our findings clearly indicate that GILZ activates AKT, a crucial signaling molecule in tumorigenesis. GILZ thus appears as potential key molecule in EOC. (Source: Molecular Cancer)
Source: Molecular Cancer - October 7, 2009 Category: Cancer & Oncology Authors: Nassima RedjimiFrancoise GaudinCyril TouboulDominique EmilieMarc PallardyArmelle Biola-VidammentHerve FernandezSophie PrevotKarl BalabanianVeronique Machelon Source Type: journals

Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and implications: Calcitriol decreased PDGF-induced ASM cell growth by inhibiting Rb and Chk1 phosphorylation. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 7, 2009 Category: Drugs & Pharmacology Authors: G Damera, HW Fogle, P Lim, EA Goncharova, H Zhao, A Banerjee, O Tliba, VP Krymskaya, RA Panettieri Jr Source Type: journals