AIDS Vaccine
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What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?
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The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of th...
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Belyakov IM, Ahlers JD Tags: J Immunol Source Type: journals
How HIV gives antibodies the slipEmail this article to a colleague.
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New structural studies may help vaccine designers hit HIV where it hurts (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - November 20, 2009 Category: Chemistry Source Type: journals
Anti-HIV Antibody ConstraintsEmail this article to a colleague.
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Despite significant efforts, an effective vaccine against the HIV-1 virus remains elusive. A site on the HIV-1 gp120 envelope glycoprotein that binds to the CD4 receptor on host cells is … [Read more] (Source: This Week in Science)
Source: This Week in Science - November 20, 2009 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: journals
Potential Strategy To Help Generate HIV-Neutralizing AntibodiesEmail this article to a colleague.
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WHAT: New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: hiv / aids Source Type: news
New findings suggest strategy to help generate HIV-neutralizing antibodiesEmail this article to a colleague.
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(NIH/National Institute of Allergy and Infectious Diseases) New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news
HIV-positive volunteers needed for H1N1 clinical trialsEmail this article to a colleague.
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Baylor College of Medicine is recruiting HIV-positive volunteers for a clinical trial sponsored by the National Institutes of Health to evaluate the immune response to the 2009 H1N1 vaccine. To qualify for the trial, HIV-positive volunteers must be in general good health and must have already received the 2009-2010 seasonal flu vaccine. Volunteers will receive two doses of the 2009 H1N1 vaccine as well as follow-up clinic visits and phone calls. Volunteers will be compensated for their time. For more information about the study, call 713-798-4912. (Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - November 19, 2009 Category: Universities & Medical Training Source Type: news
HIV-1 STEP Vaccine Trial Failure Blamed on Adenovirus ShellEmail this article to a colleague.
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The increase in HIV infections among vaccines, leading to a halt of the HIV type 1 STEP vaccine trial, has been traced to the adenovirus shell. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 18, 2009 Category: Consumer Health News Tags: hiv/aids Source Type: news
AIDS, UTI, Herpes Vaccines May Exist In 5 YearsEmail this article to a colleague.
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Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. Many could be on the market in five years or less. Contrast that with five years ago, when so many companies had abandoned the vaccine business that half the U.S. supply of flu shots was lost because of factory contamination at one of the two manufacturers left. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 18, 2009 Category: Consumer Health News Source Type: consumer
Swine flu vaccine uptakeEmail this article to a colleague.
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Several newspapers have reported that pregnant women and other vulnerable people are refusing to have the swine flu vaccine. The Times reported that a poll of GPs found that only 46% of people who were offered the vaccine have accepted it, and one doctor estimated that only 5% of pregnant women have had it.
The news reports are based on a “snapshot” survey of 107 GPs. The survey asked how likely they were to hit the government’s target of vaccinating at least half of their patients who are under 65 and in high-risk groups this winter. GPs were also asked to estimate how many of the people who were offered the vacci...
Source: NHS News Feed - November 18, 2009 Category: Consumer Health News Tags: Swine flu Source Type: news
Scientists Learn Why Failed HIV Vaccine Actually Increased the Risk of InfectionEmail this article to a colleague.
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UK and US researchers think they may have discovered why a recently studied adenovirus-based vaccine against HIV-1 actually increased the risk of infection in some individuals. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 18, 2009 Category: Consumer Health News Tags: hiv/aids Source Type: news
Also In Global Health News: Global Corruption; HIV Vaccine; Smoking; DRC AidEmail this article to a colleague.
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Global Corruption Fight Slowing, Report Says A new report from Transparency International says the fight against corruption worldwide is slowing as urgency to address the global economic downturn recedes, Bloomberg reports. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: hiv / aids Source Type: news
Also In Global Health News: Global Corruption; HIV Vaccine; Smoking; DRC AidEmail this article to a colleague.
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Global Corruption Fight Slowing, Report Says A new report from Transparency International says the fight against corruption worldwide is slowing as urgency to address the global economic downturn recedes, Bloomberg reports. (Source: HIV / AIDS News From Medical News Today)
Source: HIV / AIDS News From Medical News Today - November 18, 2009 Category: Infectious Diseases Tags: hiv / aids Source Type: news
Vaccines on horizon for Alzheimer's, herpes, AIDSEmail this article to a colleague.
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Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. (Source: CTV Health)
Source: CTV Health - November 18, 2009 Category: Consumer Health News Source Type: news
Immediate, Aggressive Spending On HIV/AIDS Could End EpidemicEmail this article to a colleague.
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Money available to treat HIV/AIDS is sufficient to end the epidemic globally, but only if we act immediately to control the spread of the disease. That was the conclusion of a study just published in the open-access journal, BMC Public Health. This approach defies conventional thinking, which recommends gradual spending over 15-20 years. Canadian Researchers found that an aggressive program over five years is the only way to end the epidemic given our current resources. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 18, 2009 Category: Allergy & Immunology Tags: hiv / aids Source Type: news
Vaccines on Horizon for AIDS, Alzheimer's, HerpesEmail this article to a colleague.
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From Associated Press (November 18, 2009)
MARIETTA, Pa._Malaria. Tuberculosis. Alzheimer's disease. AIDS.
Pandemic flu. Genital herpes. Urinary tract infections. Grass
allergies. Traveler's diarrhea. You name it, the pharmaceutical
industry is... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2009 Category: Pharmaceuticals Source Type: news
Vaccines On Horizon For AIDS, HerpesEmail this article to a colleague.
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You name it, the pharmaceutical industry is working on a vaccine to prevent it. (Source: WDSU.com - Health)
Source: WDSU.com - Health - November 18, 2009 Category: Consumer Health News Authors: WDSU.com Source Type: news
Misfiring immune system blamed for HIV vaccine failureEmail this article to a colleague.
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An HIV vaccine component may have accidentally triggered an immune response that made people more vulnerable to infection, say scientists. (Source: SciDev.Net)
Source: SciDev.Net - November 18, 2009 Category: Global & Universal Source Type: info
Vaccines for AIDS, Alzheimer's, herpes on the horizonEmail this article to a colleague.
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Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it.
Many could be on the market in... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - November 18, 2009 Category: American Health Source Type: news
Viruses within the Flaviviridae Decrease CD4 Expression and Inhibit HIV Replication in Human CD4+ Cells.Email this article to a colleague.
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Viral infections alter host cell homeostasis and this may lead to immune evasion and/or interfere with the replication of other microbes in coinfected hosts. Two flaviviruses are associated with a reduction in HIV replication or improved survival in HIV-infected people (dengue virus (DV) and GB virus type C (GBV-C)). GBV-C infection and expression of the GBV-C nonstructural protein 5A (NS5A) and the DV NS5 protein in CD4(+) T cells inhibit HIV replication in vitro. To determine whether the inhibitory effect on HIV replication is conserved among other flaviviruses and to characterize mechanism(s) of HIV inhibition, the ...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Xiang J, McLinden JH, Rydze RA, Chang Q, Kaufman TM, Klinzman D, Stapleton JT Tags: J Immunol Source Type: journals
Vaccines On Horizon For AIDS, Alzheimer's, HerpesEmail this article to a colleague.
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Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. (Source: WDSU.com - Health)
Source: WDSU.com - Health - November 17, 2009 Category: Consumer Health News Authors: WDSU.com Source Type: news
Common Cold Virus May Have Foiled HIV Vaccine TestEmail this article to a colleague.
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Associated Press - Nov. 16, 2009
WASHINGTON-The failure of an experimental AIDS vaccine trial two
years ago may have been caused by the common cold virus.
The vaccine was intended to block the spread of HIV, which
causes AIDS. But the test was... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 17, 2009 Category: Pharmaceuticals Source Type: news
Probable Cause Of HIV Vaccine FailureEmail this article to a colleague.
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The recent failure of an HIV vaccine was probably caused by the immune system reacting to the virus 'shell' used to transmit the therapy around the body, according to research published 16 November 2009 in the Proceedings of the National Academy of Sciences. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2009 Category: Consumer Health News Tags: hiv / aids Source Type: news
Probable Cause Of HIV Vaccine FailureEmail this article to a colleague.
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The recent failure of an HIV vaccine was probably caused by the immune system reacting to the virus 'shell' used to transmit the therapy around the body, according to research published 16 November 2009 in the Proceedings of the National Academy of Sciences. The trial, called 'STEP', was halted in September 2007 because preliminary results suggested that people who had been given the vaccine were more likely to be infected with HIV than people who had been given a placebo. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 17, 2009 Category: Allergy & Immunology Tags: hiv / aids Source Type: news
'Golden era' could bring vaccines against AIDS, Alzheimer's and addictions within 5 yearsEmail this article to a colleague.
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MARIETTA, Pa. (AP) — Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it.... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - November 17, 2009 Category: American Health Source Type: news
Fears over 'own goal' HIV vaccine revivedEmail this article to a colleague.
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Cold virus used in vaccine may raise HIV infection risk after all (Source: New Scientist - HIV and AIDS)
Source: New Scientist - HIV and AIDS - November 17, 2009 Category: Infectious Diseases Source Type: journals
HIV vaccine failure probably caused by virus used, says new researchEmail this article to a colleague.
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Immunity to adenovirus means some people had a higher risk of HIV infection in STEP Trial - News Release (Source: Imperial College News)
Source: Imperial College News - November 17, 2009 Category: Biomedical Science Source Type: organizations
AIDS researchers say finding immunity is key in creating vaccineEmail this article to a colleague.
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Researchers say they are closer than ever to finding a vaccine against HIV/AIDS thanks to people who have had contact with the virus but haven't become infected. (Source: CTV Health)
Source: CTV Health - November 16, 2009 Category: Consumer Health News Source Type: news
Fears over 'own goal' HIV vaccine revivedEmail this article to a colleague.
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Cold virus used in vaccine may raise HIV infection risk after all (Source: New Scientist - Health)
Source: New Scientist - Health - November 16, 2009 Category: Consumer Health News Source Type: journals
Renewed Hope for an AIDS VaccineEmail this article to a colleague.
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The long search for an AIDS vaccine has produced countless false starts and repeated failed trials, casting once bright hopes into shadows of disenchantment. The now familiar swings appeared in high relief this past fall, with news of the most recent, phase III trial in Thailand . Initial fanfare for a protective outcome gave way to disappointment after reanalysis showed that the protection could be attributed only to chance. But rather than dashing all hopes for an AIDS vaccine, the trial has heartened some researchers, who see new clues in the battle against the fatal illness. [More] (Source: Scientific American - Official RSS Feed)
Source: Scientific American - Official RSS Feed - November 16, 2009 Category: Science Tags: Biology,Health & Medicine,Society Policy,Basic Science,Ethics,Infectious Diseases,Pharmaceuticals Source Type: journals
Viral Vector Fingered in Failed HIV Vaccine (CME/CE)Email this article to a colleague.
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The well-publicized failure of an investigational HIV vaccine in the STEP trial stemmed from expansion of CD4 memory cells from prior exposure to the adenoviral vector used to deliver HIV antigens, researchers suggested. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - November 16, 2009 Category: Consumer Health News Source Type: news
AIDS researcher expects vaccine in his lifetimeEmail this article to a colleague.
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Experts at an international HIV/AIDS conference in Winnipeg say researchers around the world are closer than ever to finding a vaccine against the virus. (Source: CBC | Health)
Source: CBC | Health - November 16, 2009 Category: Consumer Health News Source Type: news
What does the report of the USMHRP Phase III study in Thailand mean for HIV and for vaccine developers?Email this article to a colleague.
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PMID: 19906099 [PubMed - in process] (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - November 15, 2009 Category: Allergy & Immunology Authors: Graham BS Tags: Clin Exp Immunol Source Type: journals
Hoping For A Fluorescent Basket Case How HIV Is Assembled And Released From Infected Cells InfectedEmail this article to a colleague.
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Although recent advances have raised hopes that a protective vaccine can be developed, acquired immunodeficiency syndrome (AIDS) remains a major public health problem. Much has been learned about HIV-1, the virus that causes the disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 14, 2009 Category: Consumer Health News Tags: hiv / aids Source Type: news
Hoping For A Fluorescent Basket Case How HIV Is Assembled And Released From Infected Cells InfectedEmail this article to a colleague.
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Although recent advances have raised hopes that a protective vaccine can be developed, acquired immunodeficiency syndrome (AIDS) remains a major public health problem. Much has been learned about HIV-1, the virus that causes the disease. However, basic aspects of person-to-person transmission and of the progressive intercellular infection that depletes the immune system of its vital T cells remain imperfectly understood. (Source: HIV / AIDS News From Medical News Today)
Source: HIV / AIDS News From Medical News Today - November 14, 2009 Category: Infectious Diseases Tags: hiv / aids Source Type: news
Exploded: myth of miracle bomb detectorEmail this article to a colleague.
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It's always interesting when people take pseudoscience out of its natural habitat – north London's Islington – and off into a place where the stakes are quite high. Like the polio vaccine scare in Nigeria. Or Aids denial in South Africa. Or, in this particular case, detecting bombs in Iraq, where the New York Times and the magician James Randi have uncovered a nonsense of truly epic proportions.A British company called ATSC is selling a device which can detect guns, ammunition, bombs, drugs, contraband ivory – and truffles. The ADE651 uses "electrostatic magnetic ion attraction" and can detect these things from a kil...
Source: Guardian Unlimited Science - November 14, 2009 Category: Science Authors: Ben Goldacre Tags: New York Times Science Iraq World news Media The Guardian Comment Comment is free Source Type: news
AID-mediated somatic hypermutation for generation of viral envelope protein diversity in patient-specific therapeutic HIV vaccines based on induction of neutralizing antibodies.Email this article to a colleague.
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The somatic hypermutation (SHM) hypothesis for R5-X4 HIV-1 switching has recently received experimental support. AID-mediated SHM in B cell lines can be used to generate patient's HIV-1 envelope protein diversity in vitro for subsequent vaccination of HIV-1-infected patient at the beginning of asymptomatic period with a resulting mixture of mutant envelope proteins. Suggested approach, which represents a vaccination against R5-X4 HIV-1 switching, might open possibilities for creation of patient-specific therapeutic HIV vaccines based on induction of neutralizing antibodies.
PMID: 19917313 [PubMed - as supplied by p...
Source: Immunology Letters - November 13, 2009 Category: Allergy & Immunology Authors: Suslov KV Tags: Immunol Lett Source Type: journals
Nanotechnology-based systems for the treatment and prevention of HIV/AIDS.Email this article to a colleague.
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The HIV/AIDS pandemic is an increasing global burden with devastating health-related and socioeconomic effects. The widespread use of antiretroviral therapy has dramatically improved life quality and expectancy of infected individuals, but limitations of currently available drug regimens and dosage forms, alongside with the extraordinary adapting capacity of the virus, have impaired further success. Alongside, circumventing the escalating number of new infections can only be attained with effective and practical preventative strategies. Recent advances in the field of drug delivery are providing evidence that engineere...
Source: Advanced Drug Delivery Reviews - November 12, 2009 Category: Drugs & Pharmacology Authors: das Neves J, Amiji MM, Bahia MF, Sarmento B Tags: Adv Drug Deliv Rev Source Type: journals
Binding Action Of 2 Key HIV Antibodies Could Lead To New Vaccine DesignEmail this article to a colleague.
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A very close and detailed study of how the most robust antibodies work to block the HIV virus as it seeks entry into healthy cells has revealed a new direction for researchers hoping to design an effective vaccine. "Our study clearly showed that we've been overlooking a very important component of antibody function," says S. Munir Alam, Ph.D. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: hiv / aids Source Type: news
Binding Action Of 2 Key HIV Antibodies Could Lead To New Vaccine DesignEmail this article to a colleague.
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A very close and detailed study of how the most robust antibodies work to block the HIV virus as it seeks entry into healthy cells has revealed a new direction for researchers hoping to design an effective vaccine. "Our study clearly showed that we've been overlooking a very important component of antibody function," says S. Munir Alam, Ph.D. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 11, 2009 Category: Allergy & Immunology Tags: hiv / aids Source Type: news
Scientists Explain Binding Action Of 2 Key HIV Antibodies; Could Lead To New Vaccine DesignEmail this article to a colleague.
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A very close and detailed study of how the most robust antibodies work to block the HIV virus as it seeks entry into healthy cells has revealed a new direction for researchers hoping to design an effective vaccine. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 11, 2009 Category: Science Source Type: news
H1N1 vaccine safety in HIV patients testedEmail this article to a colleague.
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Canadian researchers are going to study H1N1 vaccine safety and dosage needs in people living with HIV. (Source: CBC | Health)
Source: CBC | Health - November 10, 2009 Category: Consumer Health News Source Type: news
New direction for HIV vaccine researchEmail this article to a colleague.
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A very close and detailed study of how the most robust antibodies work to block the HIV virus as it seeks entry into healthy cells has revealed a new direction for scientists hoping to design an effective vaccine. "Our study clearly showed that we've been overlooking a very important component of antibody function," says S. Munir Alam, Ph.D., an associate professor of medicine at Duke University Medical Center and main author of the paper appearing in the Proceedings of the National Academy of Sciences....... (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - November 10, 2009 Category: Consumer Health News Source Type: info
Also In Global Health News: Nutritionally-Enhanced Products; Health Care In India; Cell Phones As Microscopes; GSK Pneumonia Vaccine; Men Fighting HIVEmail this article to a colleague.
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News Outlets Examine Nutritionally-Enhanced Products The East African examines the recent launch of a $21.25 million research project, at the International Sweet Potato Centre in Uganda, that aims to develop "nutritionally enhanced sweet potatoes … to reduce health problems related to vitamin A deficiency and improve food security in sub-Saharan Africa. (Source: Nutrition/Agriculture News From Medical News Today)
Source: Nutrition/Agriculture News From Medical News Today - November 10, 2009 Category: Nutrition Tags: Nutrition / Diet Source Type: news
Also In Global Health News: Nutritionally-Enhanced Products; Health Care In India; Cell Phones As Microscopes; GSK Pneumonia Vaccine; Men Fighting HIVEmail this article to a colleague.
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News Outlets Examine Nutritionally-Enhanced Products The East African examines the recent launch of a $21.25 million research project, at the International Sweet Potato Centre in Uganda, that aims to develop "nutritionally enhanced sweet potatoes … to reduce health problems related to vitamin A deficiency and improve food security in sub-Saharan Africa. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
Can Microbicides Turn the Tide against HIV?Email this article to a colleague.
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The global impact of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is increasing and traditional preventative 'safe sex' strategies do not seem to be slowing the spread of this virus. With an efficacious vaccine at least a decade away, the only strategy to avoid the ever-increasing cost of highly active antiretroviral therapy (HAART) is to develop new methods that prevent virus transmission. Microbicides are topically-applied molecules that disrupt the HIV cycle and block infection. This review discusses the current state of the art in microbicide development, looking at the most clinically...
Source: Current Pharmaceutical Design - November 10, 2009 Category: Drugs & Pharmacology Authors: Ramessar K, Sabalza M, Miralpeix B, Capell T, Christou P Tags: Curr Pharm Des Source Type: journals
Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genesEmail this article to a colleague.
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Abstract Toll-like, vitamin A and D receptors and other innate proteins participate in various immune functions. We determined whether
innate gene-sequence variations are associated with rubella vaccine-induced cytokine immune responses. We genotyped 714 healthy
children (11–19 years of age) after two doses of rubella-containing vaccine for 148 candidate SNP markers. Rubella virus-induced
cytokines were measured by ELISA. Twenty-two significant associations (range of P values 0.002–0.048) were found between SNPs in the vitamin A receptor family (RARA, RARB, TOP2B and RARG), vitamin D receptor
and do...
Source: Human Genetics - November 9, 2009 Category: Genetics & Stem Cells Tags: Human Genetics Source Type: journals
Scientists explain binding action of 2 key HIV antibodies; could lead to new vaccine designEmail this article to a colleague.
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(Duke University Medical Center) A very close and detailed study of how the most robust antibodies work to block the HIV virus as it seeks entry into healthy cells has revealed a new direction for researchers hoping to design an effective vaccine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 9, 2009 Category: Global & Universal Source Type: news
Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in ThailandEmail this article to a colleague.
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Background The development of a safe and effective vaccine against the human immunodeficiency virus type 1 (HIV-1) is critical to pandemic control. Methods In a community-based, randomized, multicenter, double-blind, placebo-controlled ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 9, 2009 Category: Internal Medicine Authors: Rerks-Ngarm, S., Pitisuttithum, P., Nitayaphan, S., Kaewkungwal, J., Chiu, J., Paris, R., Premsri, N., Namwat, C., de Souza, M., Adams, E., Benenson, M., Gurunathan, S., Tartaglia, J., McNeil, J. G., Francis, D. P., Stablein, D., Birx, D. L., Chunsuttiwat Tags: ORIGINAL ARTICLES Source Type: journals
Identification and Characterization of HLA-A*0301 epitopes in HIV-1 gag proteins using a Novel Approach.Email this article to a colleague.
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In this study we used a new approach to identify and characterize potential epitopes in the gag region containing PS mutations that significantly correlated with HLA-A*0301. The iTopia Epitope Discovery System was used to rapidly screen a panel of peptides overlapping the regions containing PS mutations and the peptides identified were assessed for relative affinity and complex stability. The potential epitopes were then validated by interferon gamma (IFN-gamma) ELISpot assays with patient PBMCs. Using this approach we identified/confirmed the predicted HLA-A*0301 epitopes in two regions of gag containing PS mutations V7I ...
Source: Journal of Immunological Methods - November 7, 2009 Category: Allergy & Immunology Authors: Semeniuk CA, Capina RE, Mendoza MG, Kimani J, Ball TB, Luo M, Plummer FA Tags: J Immunol Methods Source Type: journals
In debate over AIDS vaccine success, every detail countsEmail this article to a colleague.
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Nature Medicine 15, 1238 (2009). doi:10.1038/nm1109-1238b
Author: Roxanne Khamsi (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2009 Category: Journals (General) Authors: Roxanne Khamsi Tags: News Source Type: journals
