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Use of Sorafenib for advanced hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NICE has issued a final appraisal determination (FAD) on the... (Source: PCCAS: Full newsfeed)
Source: PCCAS: Full newsfeed - November 21, 2009 Category: Practice Management Source Type: organizations

Use of Sorafenib for advanced hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NICE has issued a final appraisal determination (FAD) on the... (Source: Cancer Plan Newsfeed)
Source: Cancer Plan Newsfeed - November 21, 2009 Category: Cancer & Oncology Source Type: organizations

Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A 70-year-old man diagnosed with hepatocellular carcinoma experienced an increase in INR values after the addition of sorafenib to his warfarin regimen. PMID: 19923313 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Moretti LV, Montalvo RO Tags: Am J Health Syst Pharm Source Type: journals

Multiphasic MDCT Enhancement Pattern of Hepatocellular Carcinoma Smaller Than 3 cm in Diameter: Tumor Size and Cellular DifferentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. The prevalent enhancement patterns of HCC smaller than 3 cm on multiphasic MDCT scans differed depending on tumor size and cellular differentiation. HCCs smaller than 2 cm and well-differentiated HCCs frequently had atypical enhancement patterns. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - November 20, 2009 Category: Radiology Authors: Yoon, S. H., Lee, J. M., So, Y. H., Hong, S. H., Kim, S. J., Han, J. K., Choi, B. I. Tags: Gastrointestinal Imaging Source Type: journals

Triple-Drug Transcatheter Arterial Chemoembolization in Unresectable Hepatocellular Carcinoma: Assessment of Survival in 124 Consecutive PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. Patients with hepatocellular carcinoma who underwent triple-drug TACE followed by liver transplantation showed the longest survival. Patients who did not receive a transplant and were treated with triple-drug TACE with a permanent embolic agent showed longer survival to 30 months after TACE than those receiving a nonpermanent embolic agent. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - November 20, 2009 Category: Radiology Authors: Gomes, A. S., Rosove, M. H., Rosen, P. J., Amado, R. G., Sayre, J. W., Monteleone, P. A., Busuttil, R. W. Tags: Vascular and Interventional Radiology Source Type: journals

Effect of Anaplerotic Fluxes and Amino Acid Availability on Hepatic Lipoapoptosis [Metabolism and Bioenergetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify metabolic pathways involved in hepatic lipoapoptosis, metabolic flux analysis using [U-13C5]glutamine as an isotopic tracer was applied to quantify phenotypic changes in H4IIEC3 hepatoma cells treated with either palmitate alone (PA-cells) or both palmitate and oleate in combination (PA/OA-cells). Our results indicate that palmitate inhibited glycolysis and lactate dehydrogenase fluxes while activating citric acid cycle (CAC) flux and glutamine uptake. This decoupling of glycolysis and CAC fluxes occurred during the period following palmitate exposure but preceding the onset of apoptosis. Oleate co-treatment re...
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Noguchi, Y., Young, J. D., Aleman, J. O., Hansen, M. E., Kelleher, J. K., Stephanopoulos, G. Tags: Metabolism and Bioenergetics Source Type: journals

NICE Appraisal Of Sorafenib For Advanced Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The National Institute for Health and Clinical Excellence (NICE) is currently appraising the use of sorafenib for advanced hepatocellular carcinoma (HCC) in patients for whom surgery or therapies in the region the cancer arose have failed or are not suitable. In its latest draft guidance, published yesterday (19 November 2009), NICE does not recommend sorafenib. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news

NICE Appraisal Of Sorafenib For Advanced Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The National Institute for Health and Clinical Excellence (NICE) is currently appraising the use of sorafenib for advanced hepatocellular carcinoma (HCC) in patients for whom surgery or therapies in the region the cancer arose have failed or are not suitable. In its latest draft guidance, published yesterday (19 November 2009), NICE does not recommend sorafenib. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Alnylam Presents New Pre-clinical Data On ALN-VSP, An RNAi Therapeutic For The Treatment Of Liver CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced new pre-clinical data from its ALN-VSP program presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International conference being held November 15 - 19, 2009 in Boston, Mass. ALN-VSP is an RNAi therapeutic currently in a Phase I clinical trial for the treatment of liver cancers, including hepatocellular carcinoma (HCC) and other solid tumors with liver involvement. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: liver Disease / Hepatitis Source Type: news

TACE it or leave it: hard choices for intermediate-stage hepatocellular carcinoma patients beyond perfect healthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Liver International)
Source: Liver International - November 20, 2009 Category: Gastroenterology Authors: Markus Peck-Radosavljevic Source Type: journals

Case report: Elevated INR with concurrent use of sorafenib and warfarinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes the case of a 70 year old patient on warfarin for atrial fibrillation, who experienced elevated INRs and haemorrhage following the addition of sorafenib. The patient was started on warfarin in April 2007 and stabilised on a dose of 36mg weekly. He was diagnosed with hepatocellular carcinoma and began treatment with sorafenib 200mg daily in September 2007. The patient arrived at the emergency room one month later with an INR of 39.5 and was admitted for lower-extremity haemorrhage and diagnosed with warfarin toxicity. Sorafenib and warfarin was discontinued. He was discharged on warfarin 3mg...
Source: NeLM - Oncology - November 20, 2009 Category: Cancer & Oncology Source Type: organizations

[Survivin antisense oligodeoxynucleotides inhibits the proliferation of hepatocellular carcinoma cells and enhances the cell chemosensitivity to 5-Fu.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: PEI-ASODN complex can significantly inhibit the proliferation of hepatocarcinoma SMMC-7721 cells and enhance the chemosensitivity of the tumor cells to 5-FU. PMID: 19923081 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Wu FY, Huang GS, Jiang JW, Wang F, Xu XD, Peng DY Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

[Establishment of a lung adenocarcinoma cell line stably expressing small interfering RNA targeting hepatoma-derived growth factor and detection of interference effect.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: HDGF expression increases in lung adenocarcinoma and SPC-A-1 cell lines. The recombinant siRNA-HDGF lentivirus vector can inhibit the expression of HDGF in SPC-A-1 cells. PMID: 19923076 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Meng J, Cao LM, Hu CP, Zhen ZY Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

Interleukin-6 Polymorphisms and Gender: Relationship with the Occurrence of Hepatocellular Carcinoma in Patients with End-Stage Liver DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oncology 2009;77:304-313 (DOI:10.1159/000260057) (Source: Karger Publishers)
Source: Karger Publishers - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Hepatic Segments and Vasculature: Projecting CT Anatomy onto Angiograms [Online Only]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatic transarterial interventional therapies such as chemoembolization and radiation embolization are important treatment options for hepatocellular carcinoma. Understanding the anatomy of individual arterial branches and hepatic segments is critical for selecting the correct embolization technique for treatment and to avoid complications. The authors describe the morphologic characteristics of hepatic arterial branches (and their mimickers) and hepatic segments on conventional angiograms. These vessels and segments include the celiac artery, the common and proper hepatic arteries, the left and right hepatic arteries and...
Source: Radiographics recent issues - November 19, 2009 Category: Radiology Authors: Furuta, T., Maeda, E., Akai, H., Hanaoka, S., Yoshioka, N., Akahane, M., Watadani, T., Ohtomo, K. Tags: Online Only Source Type: journals

Unexplained Liver Hemorrhage After Metastasis Radiofrequency AblationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered that liver metastases meant a very poor prognosis, today, due to improved systemic therapy, many patients will be candidates for local hepatic treatments such as surgery or less aggressive radiofrequency ablation. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 19, 2009 Category: Gastroenterology Tags: Colorectal Cancer Source Type: news

Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: SR can provide survival benefits for patients with 1 or 2 isolated extrahepatic metastases and who concurrently exhibit good hepatic functional reserve and general performance status as well as successful treatment of intrahepatic HCC. PMID: 19916180 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Chan KM, Yu MC, Wu TJ, Lee CF, Chen TC, Lee WC, Chen MF Tags: World J Gastroenterol Source Type: journals

NICE issues negative Final Appraisal Determination on sorafenib (first line) for advanced and metastatic hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: NICE Area: News In its Final Appraisal Determination, NICE has not recommended the use of sorafenib (first line) for the treatment of advanced and metastatic hepatocellular carcinoma in patients for whom surgical or locoregional therapies have failed or are not suitable, as it was not considered a cost-effective use of NHS resources. The appeal period for this appraisal will close on 3rd December 2009. (Source: NeLM - Oncology)
Source: NeLM - Oncology - November 19, 2009 Category: Cancer & Oncology Source Type: organizations

Clinical manifestations and survival of patients with hepatocellular carcinoma and cardiac metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hepatocellular carcinoma patients with cardiac metastases were in the advanced stages. These patients had limited survival from the diagnosis of cardiac metastases. The most common cause of death was related to HCC per se or the underlying liver disease. Only a few patients expired because of cardiac metastases. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Yu-Chun Liu, Yi-Lwun Ho, Guan-Tarn Huang, Ding-Shinn Chen, Jin-Chuan Sheu, Chien-Hung Chen Source Type: journals

Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Laparoscopic splenectomy may be superior to partial splenic embolization as a supportive intervention for cirrhotic patients with hypersplenism. Future prospective, randomized controlled patient studies are required to confirm these findings. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Morimasa Tomikawa, Tomohiko Akahoshi, Keishi Sugimachi, Yasuharu Ikeda, Kisaku Yoshida, Yuichi Tanabe, Hirofumi Kawanaka, Kenji Takenaka, Makoto Hashizume, Yoshihiko Maehara Source Type: journals

Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: When cirrhotic patients with portal hypertension have HCC with PVT, a hematogenous pathway can exist for gastric metastasis of tumor thrombi involving hepatofugal flow to the stomach after TAE or EVL apart from the major pathway of direct invasion. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Ming-Luen Hu, Wei-Chen Tai, Seng-Kee Chuah, Yi-Chun Chiu, Keng-Liang Wu, Yeh-Pin Chou, Chung-Mou Kuo, Tsung-Hui Hu, King-Wah Chiu Source Type: journals

Radiofrequency ablation therapy for hepatocellular carcinoma in elderly patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Elderly HCC patients, who have good performance status, should be treated in the same manner and with the same strategy as young HCC patients. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Atsushi Hiraoka, Kojiro Michitaka, Norio Horiike, Satoshi Hidaka, Takahide Uehara, Soichi Ichikawa, Aki Hasebe, Yasunao Miyamoto, Tomoyuki Ninomiya, Ichiro Sogabe, Yoshihiro Ishimaru, Hideki Kawasaki, Yohei Koizumi, Masashi Hirooka, Yoshimasa Yamashita, M Source Type: journals

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate the paracrine effects of hepatocarcinoma cells on human HSC using a co-culture system. Huh7 or HepG2 cells, human hepatocarcinoma cell lines, were co-cultured with primary human HSC. Intracellular calcium mobilization, proliferation, migration, expression of pro-angiogenic and fibrogenic genes, smooth muscle [alpha]-actin ([alpha]-SMA) protein expression, inflammatory properties (nuclear factor kappa B activation and interleukin 8 secretion) and intracellular signalling pathways (AKT and ERK) were analysed in HSC. Culture of HSC with Huh7 cells for 24 h stimulated HSC proliferation, migratio...
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Pau Sancho-Bru, Elena Juez, Montserrat Moreno, Valeria Khurdayan, Manuel Morales-Ruiz, Jordi Colmenero, Vicente Arroyo, David A. Brenner, Pere Ginès, Ramón Bataller Source Type: journals

Glucocorticoid and adrenalectomy effects on the rat aryl hydrocarbon receptor pathway depend on the dosing regimen and post-surgical time.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene (MC); the prototypical response is induction of drug-metabolizing enzymes. Factors that regulate AHR levels in vivo are poorly understood and it is also not clear how AHR levels affect aromatic hydrocarbon responsiveness. Our interest in pituitary-dependent regulation of AHR levels was prompted by two findings from our laboratory: (1) hypophysectomized rats have reduced hepatic levels of AHR protein; and (2) glucocorticoid...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Mullen Grey AK, Riddick DS Tags: Chem Biol Interact Source Type: journals

Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we hypothesized that fucoxanthin may cause cell cycle arrest and enhance gap junctional intercellular communication (GJIC) in SK-Hep-1 human hepatoma cells. Data revealed that fucoxanthin (1-20microM) strongly and concentration-dependently inhibited the proliferation of SK-Hep-1 cells at 24h of incubation, whereas fucoxanthin facilitated the growth of a murine embryonic hepatic (BNL CL.2) cells at 24h of incubation and only slightly slowed the cell proliferation at 48h. In SK-Hep-1 cells, fucoxanthin caused cell cycle arrest at G0/G1 phase and induced cell apoptosis, as evidenced by increased subG1 cells and...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Liu CL, Huang YS, Hosokawa M, Miyashita K, Hu ML Tags: Chem Biol Interact Source Type: journals

Outcome of endoscopic submucosal dissection for colorectal tumors in elderly peopleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions ESD for colorectal tumors resulted in favorable rates of en bloc resection in elderly people. Perforation occurred in elderly people, but these patients were cured with conservative treatment. ESD is a safe and minimally invasive treatment for elderly people with colorectal tumors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0841-9Authors Naohisa Yoshida, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku Kyoto 602-8566 JapanYuji ...
Source: International Journal of Colorectal Disease - November 18, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Erratum to: FDG PET as a prognostic predictor in the early post-therapeutic evaluation for unresectable hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00259-009-1320-9Authors Tatsuya Higashi, Shiga Medical Center Research Institute 5-4-30 Moriyama Moriyama City Shiga 524-8524 JapanEtsuro Hatano, Kyoto University Graduate School of Medicine Department of Gastroenterological Surgery 54 Kawahara-cho, Shogoin Sakyo-ku Kyoto 606-8507 JapanIwao Ikai, Kyoto University Graduate School of Medicine Department of Gastroenterological Surgery 54 Kawahara-cho, Shogoin Sakyo-ku Kyoto 606-8507 JapanRyuichi Nishii, Shiga Medical Center Research Institute 5-4-30 Moriyama Moriyama City Shiga 524-8524 JapanYuji Nakamoto, Kyoto Uni...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 18, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Unexplained liver hemorrhage after metastasis radiofrequency ablationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(World Journal of Gastroenterology) Radiofrequency ablation is a minimally invasive treatment of hepatic metastases from colon carcinoma, and can achieve good outcomes with low morbidity and mortality rates. Although relatively safe, liver radiofrequency ablation may have several complications, many of which are potentially grave. The most common complication is intra-abdominal hemorrhage with a rate of approximately 1.6 percent. Liver lacerations may also occur but only occasionally. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 17, 2009 Category: Global & Universal Source Type: news

XPD Codon 312 and 751 Polymorphisms, and AFB1 Exposure, and Hepatocellular Carcinoma RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that XPD Lys751Gln polymorphism is an important modulator of AFB1 related-HCC development in Guangxi population. (Source: BMC Cancer)
Source: BMC Cancer - November 17, 2009 Category: Cancer & Oncology Authors: Xi Dai LongYun MaYun Feng ZhouJin Guang YaoFu Zhi BanYong Zhi HuangBing Cheng Huang Source Type: journals

Are patients with non-muscle-invasive bladder cancer a suitable population for a lung cancer screening trial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To estimate the relative risk of developing a second primary neoplasm, in particular lung cancer, after having non-muscle-invasive bladder cancer (NMIBC). Patients were included in the study if they had developed NMIBC between 1995 and 2003. All clinical data were extracted from the medical records of our institution's database. The interval between neoplasms, smoking habits, histological subtypes and survival were also analysed. Patient follow-up was [ge]5 years. We found 231 patients with NMIBC, 39 of which had a second primary neoplasm: 10 lung cancer, one pancreas, one gastric, one pharynx, one liver, one parathyroid, ...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Javier del Rey, José Placer, Felip Vallmanya, Núria Pujol, Esther Prat, Rosa Miró, Antoni Gelabert Source Type: journals

Randomized Clinical Trials in Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the most pertinent randomized controlled trials with respect to surgical and adjuvant interventions that shape the current treatment algorithm for hepatocellular carcinoma. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Adam C. Yopp, William R. Jarnagin Source Type: journals

An Update on Randomized Clinical Trials in Advanced and Metastatic Colorectal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the past eight years, there have been significant advances in the treatment and outcome of patients with metastatic colorectal cancer. This is likely the result of improved imaging, staging, chemotherapy, and surgery. After conducting a standardized MEDLINE literature search, this article reviews the prospective randomized controlled trials in advanced colorectal cancer published between May 2001 and October 2008. There are a total of 96 studies, all chemotherapy-related trials, divided into five categories based on trial focus: (1) types of chemotherapy; (2) administration of adjuvant or neoadjuvant chemotherapy fo...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Shishir K. Maithel, Michael I. D'Angelica Source Type: journals

Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diagnosis and Treatment series: Current Clinical Oncology Hepatocellular cancer is the the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - November 16, 2009 Category: Databases & Libraries Tags: Oncology Source Type: organizations

Treatment of pathologic spinal fractures with combined radiofrequency ablation and balloon kyphoplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In our experience the treatment of pathologic spinal fractures with combined radiofrequency ablation and balloon kyphoplasty is safe and effective for immediate pain relief in painful spinal lesions in neurologically intact patients. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - November 16, 2009 Category: Cancer & Oncology Authors: Pavlos KatonisDritan PaskuKalliopi AlpantakiArtan BanoGeorge TzanakakisApostolos Karantans Source Type: journals

The high-risk recipient: the Eighth Annual American Society of Transplant Surgeons' State-of-the-Art Winter SymposiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion focused on various types of high-risk recipients, such as those with coronary artery disease, morbid obesity, and hepatitis C; strategies to reduce risk, such as down-staging of hepatocellular carcinoma and treatment of pulmonary hypertension; the development of alternatives to transplantation; and the degree to which risk can or should be used to define candidate selection. These approaches can modify the impact of recipient risk on transplant outcomes and permit transplantation to be applied successfully to a greater variety of patients. (Source: Clinical Transplantation)
Source: Clinical Transplantation - November 16, 2009 Category: Transplant Surgery Authors: Randall S. Sung, Elizabeth A. Pomfret, Kenneth A. Andreoni, Talia B. Baker, Thomas G. Peters Source Type: journals

Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nonalcoholic fatty liver disease (NAFLD), first described in 1980, is now recognized as one of the most common causes of elevated liver enzymes and chronic liver disease in Western countries. The incidence of NAFLD in both adults and children is rising, in conjunction with the burgeoning epidemics of obesity and type 2 diabetes mellitus. NAFLD often coexists with other sequelae of the metabolic syndrome: central obesity, type 2 diabetes, hypertension, and hyperlipidemia. NAFLD encompasses a spectrum of pathologic liver diseases ranging from simple hepatic steatosis to a predominant lobular necro-inflammation, with or w...
Source: Advances in Therapy - November 16, 2009 Category: Drugs & Pharmacology Authors: Stein LL, Dong MH, Loomba R Tags: Adv Ther Source Type: journals

A new staging system is more discriminant than conventional staging systems for unresectable hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The new staging system, accounting for both liver function and tumor characteristics, can accurately identify patients with different prognoses, particularly in the advanced phases of HCC. It should be useful as the only tool that can be applied for patients with unresectable HCC. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0722-1Authors Bai-Hong Zhang, General Hospital of People’s Liberation Army Department of Oncology 730050 Lanzhou ChinaXiang-Hui Wang, General Hospital of People’s Liberation Army Department of Oncology 730050 Lanzhou ChinaHong-Yun Yue, G...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions From our findings we conclude that bacoside A is effective to prevent DEN-induced hepatocellular carcinoma by quenching lipid peroxidation and enhancing antioxidant status through free radical scavenging mechanism and having potential of protecting endogenous enzymatic and non-enzymatic antioxidant activity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0715-0Authors Panneerselvam Janani, Presidency College Department of Zoology Chennai 600005 Tamil Nadu IndiaKanakarajan Sivakumari, Presidency College Department of Zoology Chennai 600005 Tamil Nadu IndiaArumugam...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Label-free diagnosis of human hepatocellular carcinoma by multiphoton autofluorescence microscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tzu-Lin Sun (孫梓凌), Yuan Liu (劉源), Ming-Chin Sung (宋明瑾), Hsiao-Ching Chen (陳曉菁), Chun-Hui Yang (楊淳惠) et al. Conventional diagnosis for hepatocellular carcinoma (HCC) is time consuming in sample preparation and deficient in quantitative examination. In this work, we developed multiphoton autofluorescence (MAF) microscopy as an effective and efficient tool in HCC diagnosis with qualitative imaging and quant ... [Appl. Phys. Lett. 95, 193703 (2009)] published Fri Nov 13, 2009. (Source: Applied Physics Letters)
Source: Applied Physics Letters - November 14, 2009 Category: Physics Source Type: journals

Peritoneal carcinomatosis and liver metastases from colorectal cancer treated with cytoreductive surgery perioperative intraperitoneal chemotherapy and liver resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: An aggressive therapy comprising of cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) and liver resection/ablation is generally not offered to patients with both colorectal peritoneal carcinomatosis (CRPC) and liver metastases (LM) as it no longer represents a loco-regional disease. We review the outcomes of patients who underwent an aggressive treatment with a curative intent for both CRPC and LM as a prelude towards determining the suitability of this treatment.Methods: Patients with CRPC were treated with cytoreductive surgery and perioperative intraperitoneal chemoth...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: T.C. Chua, T.D. Yan, J. Zhao, D.L. Morris Tags: Original Articles Source Type: journals

A New Prediction Model of Postoperative Complications after Major Hepatectomy for Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dig Surg 2009;26:392-399 (DOI:10.1159/000229973) (Source: Karger Publishers)
Source: Karger Publishers - November 14, 2009 Category: Cancer & Oncology Source Type: journals

Increased vascular endothelial growth factor transcription in residual hepatocellular carcinoma after open versus laparoscopic hepatectomy in a small animal modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Laparoscopic hepatic resection produces decreased VEGF mRNA expression in residual hepatoma cells compared with open resection. Decreased stimulation of angiogenesis promoters in the tumor microenvironment after minimally invasive liver resection may contribute to a lower residual disease burden and ultimately lead to a lower recurrence rate. Content Type Journal ArticleDOI 10.1007/s00464-009-0742-6Authors Kyle A. Perry, Oregon Health and Science University Department of Surgery Mail Code L223A, 3181 Sam Jackson Park Road Portland OR 97239 USAC. Kristian Enestvedt, Oregon Health and Scienc...
Source: Surgical Endoscopy - November 14, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Laparoscopic resection for hepatocellular carcinoma: a matched-pair comparative studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Laparoscopic resection of HCC for selected patients gave a better postoperative outcome without oncologic consequences. Prospective trials are required to confirm these results. Content Type Journal ArticleDOI 10.1007/s00464-009-0745-3Authors Hadrien Tranchart, Antoine Béclère Hospital Department of General Surgery 157 rue de la Porte de Trivaux 92141 Clamart Cedex FranceGiuseppe Di Giuro, Antoine Béclère Hospital Department of General Surgery 157 rue de la Porte de Trivaux 92141 Clamart Cedex FrancePanagiotis Lainas, Antoine Béclère Hospital Department of General Surgery 157 rue de l...
Source: Surgical Endoscopy - November 14, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion DWI after Gd-EOB-DTPA administration can be used as a substitute for unenhanced DWI at 3.0 T without compromising CNR and ADC of focal hepatic lesions. Content Type Journal ArticleCategory Hepatobiliary-PancreasDOI 10.1007/s00330-009-1651-8Authors Ji Soo Choi, Yonsei University College of Medicine Department of Radiology, Severance Hospital and Research Institute of Radiological Science Seoul KoreaMyeong-Jin Kim, Yonsei University College of Medicine Department of Radiology, Severance Hospital and Research Institute of Radiological Science Seoul KoreaJin-Young Choi, Yonsei University College...
Source: European Radiology - November 14, 2009 Category: Radiology Tags: European Radiology Source Type: journals

Systematic review of neoadjuvant transarterial chemoembolization for resectable hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resection of hepatocellular carcinoma (HCC) offers the only hope for cure. However, in patients undergoing resection, recurrences, in particular, intrahepatic recurrence are common. The effectiveness of transarterial chemoembolization (TACE) as a neoadjuvant therapy for unresectable HCC was exploited by numerous liver units and employed preoperatively in the setting of resectable HCC with an aim to prevent recurrence and prolong survival. A systematic literature search of databases (Medline and PubMed) to identify published studies of TACE administered preoperatively as a neoadjuvant treatment for resectable HCC was undert...
Source: Liver International - November 14, 2009 Category: Gastroenterology Authors: Terence C. Chua, Winston Liauw, Akshat Saxena, Francis Chu, Derek Glenn, Alan Chai, David L. Morris Source Type: journals

Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we demonstrated that OSM and LIF can induce hepcidin expression mainly through the JAK/STAT pathways. Further studies are warranted to evaluate the clinical significance of OSM and LIF in the development of anemia in various inflammatory diseases. PMID: 19915946 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - November 14, 2009 Category: Hematology Authors: Kanda J, Uchiyama T, Tomosugi N, Higuchi M, Uchiyama T, Kawabata H Tags: Int J Hematol Source Type: journals

The natural history of untreated HFE-related hemochromatosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemochromatosis has generally been considered to be a genetic disease in which progressive iron accumulation over many years can lead to cirrhosis of the liver, hepatocellular carcinoma, diabetes, cardiomyopathy, and arthropathy. Iron depletion by phlebotomy has been the recommended therapy although a randomized trial of phlebotomy versus no treatment has never been reported. Since the discovery of the HFE gene in 1996, it has been possible to predict the risk of developing iron overload by a simple blood test to detect C282Y homozygotes of the HFE gene. The application of the hemochromatosis genetic test in large popu...
Source: Acta Haematologica - November 13, 2009 Category: Hematology Authors: Adams PC Tags: Acta Haematol Source Type: journals

Hepatocellular carcinoma and evidence-based surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transplantation cannot be considered the most important therapeutic procedure for hepatocellular carcinoma (HCC). In France, no more than 2% of patients with HCC undergo a transplantation. Randomized controlled trial must assess the benefit to risk ratio of various potentially "curative" treatment procedures (transplantation, resection, radio-frequency ablation). PMID: 19908350 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Braillon A Tags: World J Gastroenterol Source Type: journals

Docosahexaenoic Acid Enhances Hepatic Serum Amyloid A Expression via Protein Kinase A-dependent Mechanism [Lipids and Lipoproteins: Metabolism, Regulation, and Signaling]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serum amyloid A (SAA) reduces fat deposition in adipocytes and hepatoma cells. Human SAA1 mRNA is increased by docosahexaenoic acid (DHA) treatment in human cells. These studies asked whether DHA decreases fat deposition through SAA1 and explored the mechanisms involved. We demonstrated that DHA increased human SAA1 and C/EBPβ mRNA expression in human hepatoma cells, SK-HEP-1. Utilizing a promoter deletion assay, we found that a CCAAT/enhancer-binding protein β (C/EBPβ)-binding site in the SAA1 promoter region between –242 and –102 bp was critical for DHA-mediated SAA1 expression. Mutation of the...
Source: Journal of Biological Chemistry - November 13, 2009 Category: Chemistry Authors: Tai, C. C., Chen, C. Y., Lee, H. S., Wang, Y. C., Li, T. K., Mersamm, H. J., Ding, S. T., Wang, P. H. Tags: Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Source Type: journals