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Bevacizumab for recurrent ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The radiographic response rate to bevacizumab-containing regimens is high. A prospective study is warranted. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Green, R. M., Cloughesy, T. F., Stupp, R., DeAngelis, L. M., Woyshner, E. A., Ney, D. E., Lassman, A. B. Tags: All Oncology, Primary brain tumor, Spinal cord tumor, Chemotherapy-tumor ARTICLES Source Type: journals

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heterozygous point mutations of isocitrate dehydrogenase (IDH)1 codon 132 are frequent in grade II and III gliomas. Recently, we reported an antibody specific for the IDH1R132H mutation. Here we investigate the capability of this antibody to differentiate wild type and mutated IDH1 protein in central nervous system (CNS) tumors by Western blot and immunohistochemistry. Results of protein analysis are correlated to sequencing data. In Western blot, anti-IDH1R132H mouse monoclonal antibody mIDH1R132H detected a specific band only in mutated tumors. Immunohistochemistry of 345 primary brain tumors demonstrated a strong cytopl...
Source: Brain Pathology - November 9, 2009 Category: Neurology Authors: David Capper, Susanne Weißert, Jörg Balss, Antje Habel, Jochen Meyer, Diana Jäger, Ulrike Ackermann, Claudia Tessmer, Andrey Korshunov, Hanswalter Zentgraf, Christian Hartmann, Andreas von Deimling Source Type: journals

Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE). About 664 patients with SCA and 1,057 patients with SCE were analyzed using the Surveillance, Epidemiology, and End Results database. For grade 1, 2, 3 and 4 SCA, the 5-year OS was 82, 70, 28 and 14%; the 5-year CSS was 89, 77, 36 and 20%. For SCA, lower grade, younger age, and undergoing resection significantly improved OS and CSS; treatment without radiotherapy was favorable for CSS. Smaller tumor size also improv...
Source: Journal of Neuro-Oncology - November 7, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Brain cancer propagating cells: biology, genetics and targeted therapies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer propagating cells (CPCs) within primary central nervous system (CNS) tumors (glioblastoma multiforme (GBM), medulloblastoma (MB) and ependymoma) might be integral to tumor development and perpetuation. These cells, also known as brain cancer propagating cells (BCPCs), have the ability to self-renew and proliferate. BCPCs can initiate new tumors in mice with high efficiency and these exhibit many features that are characteristic of patient's brain tumors. Accumulating evidence suggests that BCPCs might originate from the transformation of neural stem cells (NSCs) and their progenitors. Furthermore, recent studies...
Source: Trends in Molecular Medicine - November 2, 2009 Category: Molecular Biology Authors: Hadjipanayis CG, Van Meir EG Tags: Trends Mol Med Source Type: journals

Specific chromosomal imbalances as detected by array CGH in ependymomas in association with tumor location, histological subtype and gradeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in the pathogenesis of ependymoma are yet to be defined. The main objective of the present study was to identify specific patterns of chromosomal aberrations that correlate with tumor location, histological subtype and grade. Forty-five ependymoma samples were analyzed by 1-megabase resolution array comparative genomic hybridization (CGH). Association between c...
Source: Journal of Neuro-Oncology - October 29, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Laminoplasty for the treatment of extramedullary intradural tumors in the thoracic and lumbar spine: greater than two-year follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Fixing the laminae, spinous processes and ligaments with sutures can achieve satisfactory primary stability and high fusion rates for resected laminae. Additional instrumentation may be necessary in greater than three-level laminoplasty. (Source: Orthopaedic Surgery)
Source: Orthopaedic Surgery - October 28, 2009 Category: Orthopaedics Authors: Xin-yu Liu, Yan-ping Zheng, Jian-min Li Tags: ORIGINAL ARTICLES Source Type: journals

Tanycytic ependymoma of the filum terminale with pleomorphic giant cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  A tanycytic ependymoma measuring 1.5 cm in maximal dimension, which involved the filum terminale and conus medullaris of a 55-year-old woman, is reported. The tumor consisted of a compact fascicular proliferation of spindle cells having long bipolar cytoplasmic processes, and immunohistochemical and ultrastructural studies demonstrated the ependymal features of neoplastic cells. The most prominent finding was an appearance of many atypical and pleomorphic, often monstrous, giant cells, which was not associated with an increase in proliferative activity. Remarkable nuclear atypism and pleomorphism wi...
Source: Brain Tumor Pathology - October 26, 2009 Category: Neurology Tags: Brain Tumor Pathology Source Type: journals

Clinicopathological features from long-term observation of a papillary tumor of the pineal region (PTPR): a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a 17-year-old man who developed a 3-cm pineal tumor that was incompletely excised following two operations. The pathological findings presented were extensive epithelial papillary structures surrounding vessels mimicking “perivascular pseudo-rosettes,” leading to a diagnosis of “papillary ependymoma.” Subsequently, the residual tumor recurred on three separate occasions. Immunohistochemical studies showed the tumor was positive for cytokeratin 18 (CK 18), microtubule-associated protein (MAP 2), neuron-specific enolase (NSE), neuronal nuclei (NeuN), and transthyretin, consistent with mature...
Source: Brain Tumor Pathology - October 26, 2009 Category: Neurology Tags: Brain Tumor Pathology Source Type: journals

Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A large experience with dendritic cell (DC)-based vaccination for malignant brain tumours has been gained in adults. Here we focus on the results obtained in children with relapsed malignant brain tumours.In total 45 children were vaccinated: 33 high grade glioma (HGG), 5 medulloblastoma (MB)/primitive neuro-ectodermal tumour (PNET), 4 ependymoma and 3 atypical teratoid-rhabdoid tumour (ATRT). Autologous, monocyte-derived DC were generated and loaded with tumour lysate, which was used as source of tumour-associated antigens.In 38 patients peripheral blood mononuclear cells (PBMC) were obtained from leukapheresis and in 7 p...
Source: Pediatric Blood and Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Hilko Ardon, Steven De Vleeschouwer, Frank Van Calenbergh, Laurence Claes, Christof M. Kramm, Stefan Rutkowski, Johannes E.A. Wolff, Stefaan W. Van Gool Source Type: journals

Rapid spontaneous malignant progression of supratentorial tanycytic ependymoma with sarcomatous features - "Ependymosarcoma"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on an example of this paradigm, involving tanycytic ependymoma as the host tumor in a 40-year-old female who underwent two tumor extirpation procedures at one-year interval. She first presented with severe headaches, and was seen by imaging to harbor a moderately enhancing mass 2.5cm in diameter at the rostral septum pellucidum accompanied by occlusive hydrocephalus. Microscopically, the tumor consisted of solid, wavy fascicles of elongated cells that were occasionally interrupted by vague perivascular pseudorosettes. Mitotic activity was absent, and less than 1% of nuclei immunoreacted for MIB-1. A histological ...
Source: Pathology, Research and Practice - October 21, 2009 Category: Pathology Authors: Vajtai I, Kuhlen D, Kappeler A, Mariani L, Zimmermann A, Paulus W Tags: Pathol Res Pract Source Type: journals

Functional motor recovery of an infant after a huge ependymoma resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Huge supratentorial ependymomas are rarely encountered tumors, even in the infant population. A recovery from complete hemiplegia following a tumor resection including the primary motor cortex was observed.A 5-month-old girl presented with a conjugate deviation to the right and a head circumference that had gradually expanded since birth. Magnetic resonance imaging (MRI) demonstrated a well-enhanced huge mass extending into the right hemisphere. A subtotal removal with the primary motor cortex was performed. However, a regrowth of the residual tumor was observed and, thereafter, the patient underwent a subsequent...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Tatsuya Abe, Tohru Kamida, Yasutomo Momii, Mitsuhiro Anan, Hiroshi Ooba, Minoru Fujiki, Teruaki Mori Tags: Case reports Source Type: journals

Targeting ERK1/2 Activation and Proliferation in Human Primary Schwannoma cells with MEK1/2 inhibitor AZD6244.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deficiency of the tumor suppressor merlin leads to the development of multiple tumors of the nervous system, such as schwannomas, meningiomas and ependymomas. Due to the benign character of these tumors classical chemotherapy is ineffective. Current therapies, surgery and radiosurgery are local and quite invasive, thus new systemic treatments are required. We have previously described the Raf/mitogen-activated kinase (MEK)/extracellular-signal-regulated kinase (ERK) pathway activation and its role in schwannoma growth. Here, we targeted MEK1/2 known as a convergence point for multiple cascades towards ERK1/2 activation...
Source: Neurobiology of Disease - October 1, 2009 Category: Neurology Authors: Ammoun S, Ristic N, Matthies C, Hilton DA, Hanemann CO Tags: Neurobiol Dis Source Type: journals

A case of primary mediastinal ependymoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 50-year-old female complained of back pain. Computed tomography showed a well-defined spindle-shaped mass 3.4 x 1.0 cm in size in the left paravertebral posterior mediastinum at the Th 3-4 level. The tumor was completely resected via thoracoscopic surgery, which showed no invasion into the surrounding tissue. It consisted of a cyst with a tiny mural solid element. By means of histological and immunohistochemical examinations, we diagnosed the tumor as ependymoma, and the patient remains alive 59 months after resection. As far as we know, 8 reported cases with primary mediastinal ependymoma have been reported. They ha...
Source: Annals of Thoracic and Cardiovascular Surgery - October 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Mori T, Nomori H, Yoshioka M, Ikeda K, Shibata H, Ohba Y, Yoshimoto K, Iyama K Tags: Ann Thorac Cardiovasc Surg Source Type: journals

Cervical Ependymoma in a Male Adolescent With Neck and Back PainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although it is a rare and slow growing neoplasm, early detection is critical for optimal postoperative functional outcome that is directly related to the preoperative functional status. (Source: Journal of Manipulative and Physiological Therapeutics)
Source: Journal of Manipulative and Physiological Therapeutics - September 30, 2009 Category: Complementary Medicine Authors: John C.S. Cho, Anthony Miller, Norman W. Kettner Tags: Case Reports Source Type: journals

Gliosarcoma with chondroblastic osteosarcomatous differentation: report of two case with clinicopathologic and immunohistochemical features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases with an extremely rare histopathologic aldiagnosis of "gliosarcoma with features of chondroblastic osteosarcoma". PMID: 19847765 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - September 30, 2009 Category: Neurosurgery Authors: Barut F, Kandemir NO, Ozdamar SO, Gul S, Bektas S, Gun BD, Bahadir B Tags: Turk Neurosurg Source Type: journals

Unique Molecular Characteristics of Pediatric Myxopapillary EpendymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Myxopapillary ependymoma (MEPN) generally can be cured by gross total surgical resection and usually manifest a favorable prognosis. However, surgery is less curative in tumors that are large, multifocal or extend outside the thecal sac. Late recurrences may occur, particularly in pediatric patients. The role of adjuvant therapy is unclear in the clinical management of recurrent tumors. Clinical trial design requires a better understanding of tumor biology. Unique molecular features of MEPN were investigated by using microarray technology to compare the gene expression of five pediatric MEPN to 24 pediatric intracranial ep...
Source: Brain Pathology - September 29, 2009 Category: Neurology Authors: Valerie N. Barton, Andrew M. Donson, Bette K. Kleinschmidt-DeMasters, Diane K. Birks, Michael H. Handler, Nicholas K. Foreman Source Type: journals

Intraoperative imprint cytology of central neurocytoma: The great oligodendroglioma mimickerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 19-year-old female with an intraventricular tumor where imprint cytology preparations were crucial for the intraoperative diagnosis of central neurocytoma. Imprint cytology preparations show a round cell neoplasm associated with neuropil clumps and short straight capillaries admixed with tumor cell clusters. To the best of our knowledge, only a few cases describing the cytologic findings of central neurocytomas have been reported in the medical literature. The differential diagnosis, tissue correlation, clinical-radiologic features, and ancillary studies are discussed. Diagn. Cytopathol. 2009 © 2009 ...
Source: Diagnostic Cytopathology - September 29, 2009 Category: Pathology Authors: Michal Klysik, Jose Gavito, Darius Boman, Roberto N. Miranda, Fadi Hanbali, Luis E. De Las Casas Source Type: journals

Brain cancer stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Cancers comprise heterogeneous cells, ranging from highly proliferative immature precursors to more differentiated cell lineages. In the last decade, several groups have demonstrated the existence of cancer stem cells in both nonsolid solid tumors, including some of the brain: glioblastoma multiforme (GBM), medulloblastoma, and ependymoma. These cells, like their normal counterpart in homologous tissues, are multipotent, undifferentiated, self-sustaining, yet transformed cells. In particular, glioblastoma-stem like cells (GBSCs) self-renew under clonal conditions and differentiate into neuron- and g...
Source: Journal of Molecular Medicine - September 29, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals

Liver grafts from donors with central nervous system tumors: A single-center perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in our experience, despite violation of the blood-brain barrier and high-grade CNS tumors, recurrence was uncommon. Grafts from these donors are often an overlooked source of high-quality organs from younger donors and can be appropriately used, particularly in patients who, despite low Model for End-Stage Liver Disease scores, carry a high risk of mortality. Liver Transpl 15:1204-1208, 2009. © 2009 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - September 28, 2009 Category: Transplant Surgery Authors: Randeep Kashyap, Charlotte Ryan, Rajeev Sharma, Manoj K. Maloo, Saman Safadjou, Maureen Graham, David Tretheway, Ashokkumar Jain, Mark Orloff Tags: Original Articles Source Type: journals

Peripheral blood stem cell mobilization with pegfilgrastim compared to filgrastim in children and young adults with malignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pegfilgrastim, the long acting agent of rh-GCSF, has been shown to be as effective as Filgrastim in children undergoing cytotoxic chemotherapy by reducing the duration of neutropenia. Recent studies in adults have also shown that Pegfilgrastim is effective to mobilize CD34+ stem cells, resulting in earlier peripheral stem cell collections (PSCC). The aim of the study was to compare the efficacy of Pegfilgrastim with Filgrastim for CD34+ stem cell mobilization in children.Three groups of patients were compared: Group 1: six patients with Ewing Sarcoma stimulated with Filgrastim; Group 2: five patients with Ewing Sarcoma, Ep...
Source: Pediatric Blood and Cancer - September 24, 2009 Category: Cancer & Oncology Authors: Peter Fritsch, Wolfgang Schwinger, Gerold Schwantzer, Herwig Lackner, Petra Sovinz, Gerald Wendelin, Martin Benesch, Sabine Sipurzynski, Christian Urban Source Type: journals

Pure cortical supratentorial extraventricular ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bhatoe Harjinder SNeurology India 2009 57(4):517-517 (Source: Neurology India)
Source: Neurology India - September 19, 2009 Category: Neurology Authors: Bhatoe Harjinder S Source Type: journals

Sacrococcygeal extraspinal ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00701-009-0503-2Authors Nisar Ahmad Wani, Sher-I-Kashmir Institute of Medical Sciences Department of Radiodiagnosis and Imaging Srinagar Jammu and Kashmir IndiaFarooq Mir, Sher-I-Kashmir Institute of Medical Sciences Department of Radiodiagnosis and Imaging Srinagar Jammu and Kashmir IndiaAbdul Qayum, Sher-I-Kashmir Institute of Medical Sciences Department of Neurosurgery Srinagar Jammu and Kashmir IndiaParvez Nazir, Sher-I-Kashmir Institute of Medical Sciences Department of Radiodiagnosis and Imaging Srinagar Jammu and Kashmir India Journal A...
Source: Acta Neurochirurgica - September 17, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Pure cortical supratentorial extraventricular ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Moiyadi AliasgarNeurology India 2009 57(4):516-516 (Source: Neurology India)
Source: Neurology India - September 10, 2009 Category: Neurology Authors: Moiyadi Aliasgar Source Type: journals

An unusual case of intraventricular gliosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of an exclusively lateral ventricular tumor probably arising from the interventricular septum and blocking the CSF pathway. To the best of our knowledge, this is the first reported case of an exclusively intraventricular gliosarcoma. PMID: 19788054 [PubMed - in process] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - August 31, 2009 Category: Pathology Authors: Govindan A, Bhat DI, Mahadevan A, Chakraborti S, Sampath S, Chandramouli BA, Shankar SK Tags: Clin Neuropathol Source Type: journals

Podoplanin is a potential marker for the diagnosis of ependymoma: a comparative study with epithelial membrane antigen (EMA).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was undertaken to evaluate podoplanin as compared with EMA as a marker of ependymoma. A total of 16 ependymomas (WHO Grade (G) II, 9 cases; GIII, 4; myxopapillary, 2; GIII clear cell, (1) were immunohistochemically studied using antibodies against podoplanin (clones D2-40 and NZ-1) as well as an antibody against EMA (clone E29). In all cases, D2-40 and NZ-1 excellently labeled linear signals along the luminal surface of ependymal canals/rosettes, dot-like structures, and/or ringlike structures, as did E29. These structures were generally more abundant in GII ependymomas than in GIII ependymomas. A semiquantitati...
Source: Clinical Neuropathology - August 31, 2009 Category: Pathology Authors: Ishizawa K, Komori T, Shimada S, Hirose T Tags: Clin Neuropathol Source Type: journals

Ependymoma in Adults: Surgery, Reoperation and Radiotherapy for Survival.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In our experience the use of radiotherapy in adult, intracranial WHO Grade II ependymoma patients had no significant effect on prognosis. Radical surgery and eventual reoperation seems to be more favorable. PMID: 19728165 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 29, 2009 Category: Pathology Authors: Vitanovics D, Bálint K, Hanzély Z, Banczerowski P, Afra D Tags: Pathol Oncol Res Source Type: journals

Exophytic Intramedullary Mature Teratoma of the Conus Medullaris: Case Report and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Zentralbl Neurochir 2009; 70: 154-160DOI: 10.1055/s-0028-1082062Abstract Intramedullary tumors affect a small but significant portion of patients with spinal tumors. Ependymomas and astrocytomas are the most common entities. The diagnosis of a mature teratoma is extremely rare, although not in the presence of associated developmental abnormalities. The medullary conus is the most common location. Such a case with caudal exophytic growth is presented here and the literature extensively reviewed.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Zen...
Source: Zentralblatt fur Neurochirurgie - Central European Neurosurgery - August 23, 2009 Category: Neurosurgery Tags: Case Report Source Type: journals

Consensus Recommendations to Accelerate Clinical Trials for Neurofibromatosis Type 2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Both phase 0 and phase II NF2 trials are near-term options for NF2 clinical trials. The number of NF2 patients in the population remains limited, and successful recruitment will require ongoing collaboration efforts between NF2 clinics. (Clin Cancer Res 2009;15(16):5032-9). PMID: 19671848 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 10, 2009 Category: Cancer & Oncology Authors: Evans DG, Kalamarides M, Hunter-Schaedle K, Blakeley J, Allen J, Babovic-Vuskanovic D, Belzberg A, Bollag G, Chen R, Ditomaso E, Golfinos J, Harris G, Jacob A, Kalpana G, Karajannis M, Korf B, Kurzrock R, Law M, McClatchey A, Packer R, Roehm P, Rubenstein Tags: Clin Cancer Res Source Type: journals

[Intraventricular fibrous tumor: a case report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of intraventricular solitary fibrous tumor.The imaging characteristics of intraventricular solitary fibrous tumors are nonspecific; the differential diagnosis should include other tumors that can affect the ventricular system such as meningioma, high grade glioma, metastasis, subependymoma, choroid plexus papilloma, ependymoma, subependymal giant cell astrocytoma, and neurocytoma. At histological study, immunohistochemical techniques allow solitary fibrous tumor to be differentiated from fibrous meningioma and hemangiopericytoma. PMID: 19646726 [PubMed - as supplied by publisher] (Source: Radiologia)
Source: Radiologia - July 28, 2009 Category: Radiology Authors: Boada M, Gómez E, Puig J, Pedraza S Tags: Radiologia Source Type: journals

Late spinal cord metastasis of fourth ventricle ependymoma appeared nineteen years after the initial treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present an unusual case of a fourth ventricle ependymoma with metastasis to the thoracic spinal cord 19 years after the initial therapy, but without local recurrence. A 37 year-old patient underwent gross total resection of a fourth ventricle ependymoma and postoperative radiation therapy to the posterior fossa. Computed tomography (CT) scanning and/or magnetic resonance (MR) imaging performed during follow up examinations, conducted annually for ten years after the therapy, revealed no evidence of local tumor recurrence. However, 19 years after the initial treatment, the patient compl...
Source: Journal of Neuro-Oncology - July 25, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Intracranial ependymoma in children: current status and future trends on diagnosis and managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00381-009-0945-0Authors Frederick A. Boop, University of Tennessee Health Science Center Department of Neurosurgery Memphis TN USASpyros Sgouros, University of Athens Department of Neurosurgery, “Attikon” University Hospital Athens Greece Journal Child's Nervous SystemOnline ISSN 1433-0350Print ISSN 0256-7040 (Source: Child's Nervous System)
Source: Child's Nervous System - July 25, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Cervical spinal cord infarction after posterior fossa surgery: a case-based updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  With this report, we want to draw the attention of neurosurgeons to the possibility of the occurrence of this dreadful complication during posterior fossa procedures. Retrospectively, the only measures that might have helped to avoid this complication in our patient would have been using the prone position and intraoperative monitoring of evoked potentials. Content Type Journal ArticleCategory Case-Based UpdateDOI 10.1007/s00381-009-0950-3Authors Juan F. Martínez-Lage, Virgen de la Arrixaca University Hospital Unit of Pediatric Neurosurgery, Regional Service of Neurosurgery 30120 El Palma...
Source: Child's Nervous System - July 10, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

[Severe orthostatic hypotension and intramedullary tumor: A case report and review of the literature.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an interesting case of severe OH that had complicated the surgical treatment of a high cervical spinal cord ependymoma and we review the literature. PMID: 19592056 [PubMed - as supplied by publisher] (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - July 7, 2009 Category: Neurosurgery Authors: Derrey S, Maltête D, Ahtoy P, Fregey P, Proust F Tags: Neurochirurgie Source Type: journals

Ependymoma: lessons from the past, prospects for the futureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00381-009-0916-5Authors Charles Teo, Prince of Wales Private Hospital Centre for Minimally Invasive Neurosurgery Barker Street Randwick NSW 2031 AustraliaAndrew Little, Barrow Neurological Institute Phoenix AZ USA Journal Child's Nervous SystemOnline ISSN 1433-0350Print ISSN 0256-7040 (Source: Child's Nervous System)
Source: Child's Nervous System - July 6, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis Type 2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurofibromatosis Type 2 (NF2) is a rare autosomal dominant disorder characterized by the development of benign tumors of the peripheral nervous system and the CNS, including schwannomas, meningiomas, and ependymomas. The gene responsible for the development of NF2 acts as a tumor suppressor gene. Stereotactic radiotherapy (SRT) or single-fraction stereotactic radiosurgery has been increasingly used in the past decades to treat benign tumors in patients with NF2. These radiotherapy methods are less invasive and can be potentially used to treat multiple tumors in a single session. The risk of inducing malignancy is uncl...
Source: Journal of Neurosurgery - July 2, 2009 Category: Neurosurgery Authors: Carlson ML, Babovic-Vuksanovic D, Messiaen L, Scheithauer BM, Neff BA, Link MJ Tags: J Neurosurg Source Type: journals

Cancer risk among children with very low birth weights.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggested no association between most cancers and very low birth weight, with the exception of the known association of hepatoblastoma and possibly moderately increased risks of other gliomas and retinoblastoma, which may warrant confirmation. PMID: 19564288 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Spector LG, Puumala SE, Carozza SE, Chow EJ, Fox EE, Horel S, Johnson KJ, McLaughlin CC, Reynolds P, Behren JV, Mueller BA Tags: Pediatrics Source Type: journals

Temozolomide for recurrent intracranial supratentorial platinum-refractory ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the authors' knowledge, there currently is no standard therapy for platinum-resistant ependymoma; hence, a need exists for new therapies. In the current study, a retrospective evaluation of temozolomide (TMZ) in adults with recurrent, supratentorial, platinum-refractory, World Health Organization grade 2 ependymoma was performed, with an objective of determining 6-month progression-free survival (PFS).A total of 25 patients, ages 28 to 63 years, with recurrent ependymoma were treated. All patients had previously been treated with surgery, radiotherapy, and platinum-based chemotherapy (cisplatin in 15 patients and carbop...
Source: Cancer - June 29, 2009 Category: Cancer & Oncology Authors: Marc C. Chamberlain, Sandra K. Johnston Source Type: journals

Pediatric Brain Tumors: Current Treatment Strategies and Future Therapeutic ApproachesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article will outline current and future therapeutic strategies for the most common pediatric CNS tumors, including primitive neuroectodermal tumors such as medulloblastoma, as well as astrocytomas and ependymomas. (Source: Neurotherapeutics)
Source: Neurotherapeutics - June 29, 2009 Category: Neurology Authors: Sabine Mueller, Susan Chang Tags: Review Articles Source Type: journals

Ependymoma: lessons from the past, prospects for the futureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00381-009-0915-6Authors Eric Bouffet, the Hospital for Sick Children Neuro-oncology program, Division of Haematology/Oncology Toronto CanadaUri Tabori, the Hospital for Sick Children Neuro-oncology program, Division of Haematology/Oncology Toronto CanadaAnnie Huang, the Hospital for Sick Children Neuro-oncology program, Division of Haematology/Oncology Toronto CanadaUte Bartels, the Hospital for Sick Children Neuro-oncology program, Division of Haematology/Oncology Toronto Canada Journal Child's Nervous SystemOnline ISSN 1433-0350Print ISSN 02...
Source: Child's Nervous System - June 29, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Cancer Risk Among Children With Very Low Birth WeightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggested no association between most cancers and very low birth weight, with the exception of the known association of hepatoblastoma and possibly moderately increased risks of other gliomas and retinoblastoma, which may warrant confirmation. (Source: PEDIATRICS)
Source: PEDIATRICS - June 28, 2009 Category: Pediatrics Authors: Spector, L. G., Puumala, S. E., Carozza, S. E., Chow, E. J., Fox, E. E., Horel, S., Johnson, K. J., McLaughlin, C. C., Reynolds, P., Behren, J. V., Mueller, B. A. Tags: Premature & Newborn ARTICLES Source Type: journals

Cancer Stem Cells in Pediatric Brain Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Central nervous system (CNS) tumors remain the leading cause of death among pediatric neoplasms. Although standard therapies cure many pediatric CNS tumors, the long-term cognitive and physical consequences of these therapies are devastating. Furthermore, recurrent disease carries a dismal prognosis. Although recent studies have focused on molecular mechanisms that underlie the initiation and progression of adult glioblastoma multiforme (GBM), these tumors differ phenotypically and at a molecular level from pediatric brain tumors. Recent investigations have identified a stem cell population, termed "brain tumor stem ce...
Source: Current Stem Cell Research and Therapy - June 27, 2009 Category: Stem Cells Authors: Lasky JL, Choe M, Nakano I Tags: Curr Stem Cell Res Ther Source Type: journals

Neuropsychological sequelae and quality of life following treatment of posterior fossa ependymomas in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Careful neuropsychological assessment of these children and early intervention will maximize chances for recovery and improvement of academic functions and quality of life issues. Content Type Journal ArticleCategory Invited PaperDOI 10.1007/s00381-009-0927-2Authors Constantinos Charalambides, “Attikon” University Hospital Pediatric Neurosurgery Rimini 1, Chaidari Athens 124 62 GreeceArgyris Dinopoulos, “Attikon” University Hospital Pediatric Neurology Rimini 1, Chaidari Athens 124 62 GreeceSpyros Sgouros, “Attikon” University Hospital Pediatric Neurosurgery Rimini 1, Chaidari At...
Source: Child's Nervous System - June 25, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Neurofibromatosis type 2 (NF2): A clinical and molecular reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurofibromatosis type 2 (NF2) is a tumour-prone disorder characterised by the development of multiple schwannomas and meningiomas. Prevalence (initially estimated at 1: 200,000) is around 1 in 60,000. Affected individuals inevitably develop schwannomas, typically affecting both vestibular nerves and leading to hearing loss and deafness. The majority of patients present with hearing loss, which is usually unilateral at onset and may be accompanied or preceded by tinnitus. Vestibular schwannomas may also cause dizziness or imbalance as a first symptom. Nausea, vomiting or true vertigo are rare symptoms, except in late-stage...
Source: Orphanet Journal of Rare Diseases - June 18, 2009 Category: Internal Medicine Authors: D Gareth Evans Source Type: journals

The genetic and epigenetic basis of ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  The paucity of in vitro and in vivo model systems for ependymoma compound the difficulties outlined above. In this review, we discuss the published literature on ependymoma genetics and epigenetics and discuss possible future directions for the field. Content Type Journal ArticleCategory Invited PaperDOI 10.1007/s00381-009-0928-1Authors Stephen C. Mack, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children Division of Neurosurgery Toronto ON CanadaMichael D. Taylor, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children Division of Neurosur...
Source: Child's Nervous System - June 18, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Outcome of teenagers and young adults with ependymoma: The Royal Marsden experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the Royal Marsden Hospital experience treating TYA with ependymoma. Materials and methods  Sixteen TYA were treated for ependymoma from 1971 to 2004 and are compared to 24 children (not infants) treated in the same period. Results  Twelve TYA (75%) received treatment in a neuro-oncology unit. Average time from symptoms to diagnosis was 183 days for TYA vs. 61.2 for children (p = 0.005). Two TYA (12.5% vs. 41.6% for children, p = 0.08) were enrolled in a clinical trial. Only 25% of TYA achieved gross total resection, all of them received radiotherapy and five of th...
Source: Child's Nervous System - June 17, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ependymomas derive from ependymal cells that cover the cerebral ventricles and the central canal of the spinal cord. The molecular alterations leading to ependymomal oncogenesis are not completely understood.The authors performed array-based expression profiling on a series of 34 frozen ependymal tumors with different localizations and histologic grades. Data were analyzed by nonsupervised and supervised clustering methods along with Gene Ontology and Pathway Analyzer tools.Class discovery experiments indicated a strong correlation between profiles and tumor localization as well as World Health Organization (WHO) tumor gra...
Source: Cancer - June 16, 2009 Category: Cancer & Oncology Authors: Thomas Palm, Dominique Figarella-Branger, Françoise Chapon, Catherine Lacroix, Françoise Gray, Francesco Scaravilli, David W. Ellison, Isabelle Salmon, Miikka Vikkula, Catherine Godfraind Source Type: journals

Beyond Grade: Molecular Pathology of Malignant GliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High-grade gliomas (HGGs) represent a heterogenous group of tumors and account for most primary brain tumors. Despite aggressive therapies, they are invariably associated with poor patient outcome. These tumors include the anaplastic (World Health Organization [WHO] grade III) histologies of astrocytomas, oligodendrogliomas, and ependymomas and the WHO grade IV glioblastoma multiforme (GBM). The recent elucidation of the fundamental molecular alterations associated with these tumors has begun to unravel the critical events in their tumorigenesis but for the most part has done little to alter patient survival. Prognosticati...
Source: Seminars in Radiation Oncology - June 15, 2009 Category: Cancer & Oncology Authors: Erik P. Sulman, Marisol Guerrero, Ken Aldape Source Type: journals

Pigmented ependymoma with signet-ring cells and Rosenthal fibers: A rare variant of ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35-year-old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arranged resembling oligodendroglioma. Pseudovascular and ependymal rosettes were observed only in focal areas. Additionally, some tumor cells contained brown cytoplasmic pigment, which was histochemically compatible with lipofuscin and neuromelanin. On immunohistochemical examination, the tumor cells were positive for S100, glial fibr...
Source: Neuropathology - June 7, 2009 Category: Neurology Authors: Yesim Ertan, Banu Sarsık, Erkin Özgiray, Ömer Kitis, Tayfun Dalbastı, Taner Akalın Source Type: journals

Infratentorial ependymomas: prognostic factors and outcome analysis in a multi-center retrospective series of 106 adult patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  This study highlights the key role of histology in the clinical outcome and the fact that gross total resection is a main prognostic factor and the treatment of choice for posterior fossa ependymomas. The use of adjuvant RT in patients with incompletely resected WHO grade II ependymomas appears beneficial, but its effect on high-grade tumors remains to be determined. Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0417-zAuthors Jacques Guyotat, “Pierre Wertheimer” GHE Neurological Hospital Department of Neurosurgery Lyon FrancePhilippe Metellus, Timone Hospi...
Source: Acta Neurochirurgica - June 5, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Sacrococcygeal immature teratoma with malignant ependymoma componentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - June 2, 2009 Category: Cancer & Oncology Authors: Claudia Busse, Tipu Nazeer, Vikramjit S. Kanwar, Suzanne Wolden, Michael P. LaQuaglia, Marc Rosenblum Source Type: journals