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This page shows you the latest news and research items in this category.

DICER1 exons 25 and 26 mutations are rare in common human tumors besides Sertoli‐Leydig cell tumor
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - April 16, 2013 Category: Pathology Authors: Min Sung Kim, Sung Hak Lee, Nam Jin Yoo, Sug Hyung Lee Tags: Correspondence Source Type: research

Gonadal malignancy in 13 consecutive collected patients with disorders of sex development (DSD) from Semarang (Indonesia)
Conclusions In spite of the significantly lower risk of GCC in the general Asian population, DSD is a dominant risk factor. The study demonstrates the power of immunohistochemical markers for (early) diagnosis. This knowledge will deepen understanding of the pathobiology of GCC and clinical handling of patients with DSD, globally. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - February 21, 2013 Category: Pathology Authors: Juniarto, A. Z., Setyawati, B. A., Miranti, I. P., Santosa, A., Hersmus, R., Stoop, H., Cools, M., Oosterhuis, J. W., Drop, S. L. S., Faradz, S. M. H., Looijenga, L. H. J. Tags: Urological cancer, Adrenal disorders Original article Source Type: research

Switch of cadherin expression as a diagnostic tool for Leydig cell tumours
Leydig cell tumours comprise about 3% of all testicular tumours. The pathogenesis of Leydig cell tumours is still poorly understood. We investigated testis with Leydig cell hyperplasia and Leydig cell tumours for their expression pattern of P‐ and N‐cadherin. We could show a switch of expression of P‐ and N‐cadherin in Leydig cell hyperplasia and Leydig cell tumours in comparison with normal Leydig cells. Cadherins could be established as a new immunohistochemical marker for this testicular tumour entity; their possible role in tumour genesis will be discussed. (Source: APMIS)
Source: APMIS - February 1, 2013 Category: Research Authors: Bremmer F, Schweyer S, Martin‐Ortega M, Hemmerlein B, Strauss A, Radzun HJ, Behnes CL Tags: Original Article Source Type: research

The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained {beta}-catenin signaling
Dysregulated WNT/β-catenin signaling in murine testes results in a phenotype with complete germ cell loss that resembles human Sertoli cell-only syndrome. In other systems, including the ovary, dysregulated WNT/β-catenin induces tumorigenesis but no tumors are observed in the mutant testes without deletion of a tumor suppressor, such as phosphatase and tensin homolog (PTEN). Müllerian inhibiting substance (MIS, also known as AMH), a member of the transforming growth factor-β family of growth factors responsible for Müllerian duct regression in fetal males, has been shown to inhibit tumor growth in ...
Source: Carcinogenesis - November 30, 2012 Category: Cancer & Oncology Authors: Tanwar, P. S., Commandeur, A. E., Zhang, L., Taketo, M. M., Teixeira, J. M. Tags: Original Manuscript Source Type: research

Primary Leydig cell tumour of epididymis: a rare case report with review of literature
Summary Leydig cell tumour (LCT) is an uncommon tumour that typically occurs in the testis. Primary epididymal LCT is extremely rare. To the best of our knowledge, only two cases have been reported in the world literature. Herein, we report a case of primary epididymal LCT in a 41‐year‐old Chinese male. The patient presented with right epididymal swelling for 3 months without endocrine manifestations, including gynaecomastia and decreased libido. Scrotal ultrasound demonstrated a mass about 1.5 cm in diameter entirely in the cephalic region of right epididymis. No abnormality was found in his bilateral testes. The pa...
Source: Andrologia - November 29, 2012 Category: Urology & Nephrology Authors: Y. Huang, J. Song, M. Xu, Q. Zan Tags: Case Report Source Type: research

Treatment of high risk Sertoli–Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog
We report two unusual cases with bilateral SLCTs suggesting evidence of genetic predisposition and at high risk of recurrence. To reduce this risk, we exploited the use of GnRH analog to lower gondadotropin and potentially directly inhibit the tumors through expressed GnRH receptors. We used it as maintenance antitumor therapy for 2 years after completion of chemotherapy, to cover the period of risk for recurrence. Both patients remain in complete remission at >2 years after completing leuprorelin therapy. Of note, both patients carry DICER1 mutations, frequently found in pleuropulmonary blastoma syndrome. Pediatr Blood...
Source: Pediatric Blood and Cancer - November 28, 2012 Category: Cancer & Oncology Authors: Harsha Prasada Lashkari, Ruth Nash, Assunta Albanese, Bruce Okoye, Robert Millar, Kathy Pritchard‐Jones Tags: Research Article Source Type: research

Bilateral Ovarian Sertoli–Leydig Cell Tumors Associated with a Unilateral Dermoid Cyst: An Exceptionally Rare Association
Journal of Gynecologic Surgery , Vol. 0, No. 0. (Source: Journal of Gynecologic Surgery)
Source: Journal of Gynecologic Surgery - November 19, 2012 Category: OBGYN Tags: article Source Type: research

Inhibition of leydig tumor growth by farnesoid X receptor activation: The in vitro and in vivo basis for a novel therapeutic strategy
Abstract Leydig cell tumors are the most common tumors of the gonadal stroma and represent about 3% of all testicular neoplasms. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available.We have recently reported that Farnesoid X Receptor (FXR) is expressed in R2C Leydig tumor cells, and it reduces the estrogen‐dependent cell proliferation by negatively regulating aromatase expression. Here, we demonstrated that treatment with GW4064, a specific FXR agonist, markedly reduced Leydig tumor growth in vivo by inhibiting proliferation an...
Source: International Journal of Cancer - October 31, 2012 Category: Cancer & Oncology Authors: Stefania Catalano, Salvatore Panza, Rocco Malivindi, Cinzia Giordano, Ines Barone, Gianluca Bossi, Marilena Lanzino, Rosa Sirianni, Loredana Mauro, Diego Sisci, Daniela Bonofiglio, Sebastiano Andò Tags: Cancer Cell Biology Source Type: research

Malignant Ovarian Sertoli-Leydig Cell Tumor Localized With Selective Ovarian Vein Sampling
Abstract: Sertoli-Leydig cell tumors (SLCT) are rare, comprising less than 0.5% of ovarian neoplasms. They are most often diagnosed in premenopausal women and may produce androgens, resulting in hirsuitism, voice deepening, frontal balding, terminal hair growth, and clitoromegaly. SLCT are malignant in 15%–20% of cases. We discuss a 25-year-old patient with persistent hyperandrogenemia. Noninvasive imaging cannot conclusively differentiate between SCLT and other diagnoses such as polycystic ovary syndrome, ovarian hyperthecosis, idiopathic hyperandrogenism, idiopathic hirsuitism, and 21-hydroxylase-deficient nonclassic a...
Source: The Journal of Minimally Invasive Gynecology - October 22, 2012 Category: OBGYN Authors: Caitlin Dunne, Jon C. Havelock Tags: Case Reports Source Type: research

Proliferative Effect of Histamine on MA-10 Leydig Tumor Cells Mediated Through HRH2 Activation, Transient Elevation in cAMP Production, and Increased Extracellular Signal-Regulated Kinase Phosphorylation Levels.
Abstract Mast cells (MC) occur normally in the testis with a species specific distribution, yet their precise role remains unclear. Testicular MC express histidine decarboxylase (HDC), the unique enzyme responsible for histamine (HA) generation. Evidence accumulated to date supports a role for HA as local regulator of steroidogenesis via functional H1 and H2 receptor subtypes (HRH1 and HRH2, respectively) present in Leydig cells. Given that HA is a well-known modulator of physiological and pathological proliferation in many different cell types, in the present study we aimed to evaluate whether HA might contribute ...
Source: Biology of Reproduction - October 17, 2012 Category: Reproduction Medicine Authors: Pagotto RM, Monzón CM, Besio Moreno M, Pignataro OP, Mondillo C Tags: Biol Reprod Source Type: research

DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours
Conclusion: Overall our findings suggest a mutation frequency in TGCTs of ~1%. We conclude therefore that hot-spot mutations, frequently seen in Sertoli-Leydig cell tumours, are not common in TGCTs. (Source: BMC Research Notes)
Source: BMC Research Notes - October 15, 2012 Category: Research Authors: Carmela de BoerRonak EiniAd GillisHans StoopLeendert LooijengaStefan White Source Type: research

Testicular Tumors in Patients with Exstrophy-Epispadias Complex
Conclusions: The observation of comorbid testicular tumor in males with exstrophy-epispadias complex should prompt a preventive health examination after puberty, which gives these patients the opportunity for further appropriate diagnostics and treatment if necessary. Biopsy is recommended for sonographically detected intratesticular lesions. Organ sparing procedures are worth considering, especially when stromal tumors with favorable outcome are discovered. However, current oncologic principles must be strictly followed. Although the etiology and true incidence of testicular tumors in exstrophy-epispadias complex are sti...
Source: The Journal of Urology - August 20, 2012 Category: Urology & Nephrology Authors: Anne K. Ebert, Sabine Kliesch, Claudia Neissner, Heiko Reutter, Wolfgang H. Rösch Tags: Pediatric Urology Source Type: research

Finasteride: Leydig cell tumour of the testis: case report
(Source: Reactions)
Source: Reactions - August 16, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Leydig cell tumor of the testis in tuberous sclerosis: lack of second hit events.
PMID: 22707517 [PubMed - in process] (Source: The Oncologist)
Source: The Oncologist - August 6, 2012 Category: Cancer & Oncology Authors: Malinowska IA, Shepherd CW, Donnelly DE, Hardy R, Clarke R, Kwiatkowski DJ, Morrison PJ Tags: Oncologist Source Type: research

Prepubertal testicular and paratesticular tumors in China: a single-center experience over a 10-year period
Conclusions: Most of the prepubertal testicular lesions were benign, and the most common histologic subtype was teratoma. Our experience with testis-sparing procedures supports the current trends that less invasive treatment should be performed for benign lesions. This study confirms the excellent cure rates obtained in children with prepubertal testicular tumors. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - August 1, 2012 Category: Surgery Authors: Xiaohao Wang, Shan Xu, Daxing Tang, Minju Li, Dehua Wu, Yong Huang Tags: Original Articles Source Type: research

Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats.
Abstract In order to assess the potential chronic toxicity and tumorigenicity of ammonium perfluorooctanoate (APFO), a 2-year dietary study was conducted with male and female rats fed 30ppm or 300ppm (approximately 1.5 and 15mg/kg). In males fed 300ppm, mean body weights were lower across most of the test period and survival in these rats was greater than that seen either in the 30ppm or the control group. Non-neoplastic effects were observed in liver in rats fed 300ppm and included elevated liver weight, an increase in the incidence of diffuse hepatocellular hypertrophy, portal mononuclear cell infiltration, and m...
Source: Toxicology - July 31, 2012 Category: Toxicology Authors: Butenhoff JL, Kennedy GL, Chang SC, Olsen GW Tags: Toxicology Source Type: research

A Clinicopathological Analysis of 40 cases of Ovarian Sertoli-Leydig Cell Tumors.
CONCLUSIONS: The prognosis of SLCTs is good, although poorly differentiated tumors may recur. Conservative surgery is acceptable for young patients wishing to preserve fertility, and postoperative adjuvant chemotherapy and long-term follow up are recommended to those with high-risk factors. PMID: 22850410 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 28, 2012 Category: Cancer & Oncology Authors: Gui T, Yang J, Zhang Y, Yu Q, Shen K, Wan X, Xiang Y, Xiao Y, Guo L, Cao D Tags: Gynecol Oncol Source Type: research

FOXL2 Mutations in Granulosa Cell Tumors Occurring in Males.
Conclusions.-The FOXL2 402C→G (C134W) mutation is also present in adult-type granulosa cell tumors occurring in men, although in a smaller proportion when compared with the rates reported in women. FOXL2 mutational analysis can be a helpful in the diagnosis of granulosa cell tumors of the testis. PMID: 22742556 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 1, 2012 Category: Laboratory Medicine Authors: Lima JF, Jin L, de Araujo AR, Erikson-Johnson MR, Oliveira AM, Sebo TJ, Keeney GL, Medeiros F Tags: Arch Pathol Lab Med Source Type: research

Leydig Cell Tumors in Children: Contrasting Clinical, Hormonal, Anatomical, and Molecular Characteristics in Boys and Girls
Conclusions: Leydig cell tumors in children display clinical, hormonal, anatomical, and molecular sexual dimorphism. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 25, 2012 Category: Pediatrics Authors: Patricia Olivier, Judith Simoneau-Roy, Diane Francoeur, Hervé Sartelet, Jasmine Parma, Gilbert Vassart, Guy Van Vliet Tags: Original Articles Source Type: research

Leydig Cell Tumors of the Testis in Tuberous Sclerosis: Lack of Second Hit Events.
PMID: 22707517 [PubMed - as supplied by publisher] (Source: The Oncologist)
Source: The Oncologist - June 15, 2012 Category: Cancer & Oncology Authors: Malinowska IA, Shepherd CW, Donnelly DE, Hardy R, Clarke R, Kwiatkowski DJ, Morrison PJ Tags: Oncologist Source Type: research

Leydig cell tumor of the spermatic cord in an adolescent affected by congenital adrenal hyperplasia
We report the first case of a patient with extratesticular Leydig cell tumor associated with congenital adrenal hyperplasia. An 18‐year‐old congenital adrenal hyperplasia patient presented with a palpable and asymptomatic right extratesticular mass. Color Doppler sonography confirmed the presence of a capsulated and vascularised lesion. Sieric tumor markers were negative. The patient underwent surgical scrotal exploration through an inguinal right incision. The mass, 18 mm in size and located within the spermatic cord, was removed and final pathology diagnosed a benign Leydig cell tumor. (Source: International Journal of Urology)
Source: International Journal of Urology - June 13, 2012 Category: Urology & Nephrology Authors: Matteo Ferrari, Marco Raber, Umberto Capitanio, Gianni Russo, Matilde Ferrario, Nathalie Rizzo, Massimo Freschi, Patrizio Rigatti, Francesco Montorsi Source Type: research

Sertoli‐Leydig cell tumor of the ovary: Analysis of a single institution database
Conclusion: As most Sertoli‐Leydig cell tumors of the ovary are seen in young women and detected while still in the early stages, a favorable outcome can be achieved by conservative surgery. Patients with moderate and poorly differentiated types of tumors benefit from adjuvant chemotherapy. Recurrences tend to occur early and are commonly seen in patients with poorly differentiated tumors. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - June 1, 2012 Category: OBGYN Authors: Rani Akhil Bhat, Yong Kuei Lim, Yin Nin Chia, Kwai Lam Yam Source Type: research

First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease
We report on the case of a 16-year-old girl diagnosed in 2001 with Hodgkin's disease (HD), subtype nodular-sclerosing, Ann-Arbor classification Stage II A. She received standard chemotherapy with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD), and radiotherapy, but disease progressed under treatment. As salvage therapy, she received ifosfamide, epirubicin, etoposide (IEV), followed by an autologous haematopoietic stem cell transplantation (HSCT), and obtained the first complete remission (CR). In 2003, the patient relapsed in the right axillary lymph nodes and homolateral pectoralis muscle; she received bleomyci...
Source: Leukemia Research - May 25, 2012 Category: Hematology Authors: Salvatore Perrone, Irene Pecorella, Walter Barberi, Veronica Valle, Giovanni Fernando Torelli, Fiammetta Natalino, Caterina Mercanti, Robin Foà, Anna Paola Iori Tags: E-page Letters (available online only) Source Type: research

Spermatogenesis in a Prepubertal Boy
A 7.5-year-old boy was evaluated for sparse unilateral right scrotal hair. No somatic growth spurt, acne, voice changes, body odor, or enlargement of penis was observed. Testicular volumes were 4 mL on the right and 2 mL on the left. Bone age was 6 years. Basal and stimulated gonadotropins and serum testosterone were in the prepubertal range. Adrenal androgens, 17-hydroxyprogesterone, and urinary steroid profile were normal. A diagnosis of isolated premature pubarche was made. At review 6 months later, no pubertal progression or acceleration in growth velocity was seen. Repeat ultrasound revealed a 2 × 3 × 3 mm hypoechoi...
Source: The Journal of Pediatrics - May 11, 2012 Category: Pediatrics Authors: Michael J. O'Grady, Niamh McGrath, Feargal M. Quinn, Michael L. Capra, Michael B. McDermott, Nuala P. Murphy Tags: Insights Source Type: research

Assessment of Circulating Hormones in Regulatory Toxicity Studies II. Male Reproductive Hormones.
Abstract When test article-related testicular toxicity or Leydig cell tumors are identified in nonclinical studies, the measurement of circulating hormones such as luteinizing hormone, follicle-stimulating hormone, inhibin, testosterone, or prolactin is often considered in order to aid mechanistic investigations or to identify potential biomarkers in man. Although some hormone levels are relatively constant, others are subject to wide variability owing to pulsatility of secretion, diurnal rhythms, and stress. To avoid being misled, it is important that this variation is factored into any study design that includes ...
Source: Toxicologic Pathology - May 2, 2012 Category: Pathology Authors: Chapin RE, Creasy DM Tags: Toxicol Pathol Source Type: research

Ovarian Sertoli-Leydig cell tumors. A retrospective MITO study.
CONCLUSIONS: The prognosis of patients with grade 1 SLCT is excellent without adjuvant chemotherapy. Patients with advanced stage or grade 2-3 tumors appear to benefit from postoperative chemotherapy. PMID: 22446621 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 21, 2012 Category: Cancer & Oncology Authors: Sigismondi C, Gadducci A, Lorusso D, Candiani M, Breda E, Raspagliesi F, Cormio G, Marinaccio M, Mangili G Tags: Gynecol Oncol Source Type: research

Ovarian non-small cell neuroendocrine carcinoma associated with increased HCG beta
A 21-year-old virgin presented with abdominal discomfort and pelvic mass. Laparotomy revealed non-ruptured right ovarian tumour about 5 cm in diameter with no ascites. No extra-ovarian disease was noted intraoperatively. She underwent right salpingo-oophorectomy at a local hospital. Pathological diagnosis was right ovarian Sertoli–Leydig cell tumour with heterogeneous components. Subsequently, she received three courses of combined chemotherapy composed of bleomycin, etoposide and cisplatin, but the disease had been progressing. At the time of admission to our hospital just 4 months later from the initial o...
Source: Journal of Clinical Pathology - March 19, 2012 Category: Pathology Authors: Sun, Z., Yang, J., Guo, L. Tags: PostScript Source Type: research

Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is in...
Source: Advances in Pharmacological Sciences - February 12, 2012 Category: Drugs & Pharmacology Source Type: research

The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour
Conclusions: This suggests that, despite their similar morphological appearances, the GCT‐like component of gynandroblastoma has a different molecular basis from conventional adult‐type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Richard Oparka, Andrew Cassidy, Stephanie Reilly, Alasdair Stenhouse, W Glenn McCluggage, C Simon Herrington Tags: SHORT REPORT Source Type: research

Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour.
ConclusionsOur results strongly suggests that the elevated levels of SF-1 have induced PII-regulated CYP19 transcription in this tumour. These findings are of relevance to the understanding of CYP19 up-regulation in general, which may occur in several tissues, including breast cancer. PMID: 22301800 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 1, 2012 Category: Endocrinology Authors: Straume AH, Løvås K, Miletic H, Gravdal K, Lønning PE, Knappskog S Tags: Eur J Endocrinol Source Type: research

The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour
Conclusions: This suggests that, despite their similar morphological appearances, the GCT‐like component of gynandroblastoma has a different molecular basis from conventional adult‐type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Richard OparkaAndrew CassidyStephanie ReillyAlasdair StenhouseW Glenn McCluggageC Simon Herrington Tags: SHORT REPORT Source Type: research

Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations
amp; D Ashley Hill (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - December 9, 2011 Category: Pathology Authors: Louis P DehnerJason A JarzembowskiD Ashley Hill Tags: adenosarcoma DICER1 embryonal rhabdomyosarcoma pleuropulmonary blastoma Sertoli–Leydig cell tumor uterine cervix Source Type: research

Expression of carbonic anhydrase IX in genitourinary and adrenal tumours
Conclusions: Carbonic anhydrase IX is a sensitive marker for clear cell RCC in core biopsies. However, other genitourinary or adrenal tumours that can have a clear cell appearance including urothelial, squamous cell, clear cell adeno and adrenal cortical carcinoma and Sertoli cell tumour express CAIX. Knowledge of expression overlap between these entities may prevent incorrect interpretation of immunohistochemical results, particularly if limited tissue is available. (Source: Histopathology)
Source: Histopathology - December 1, 2011 Category: Pathology Authors: Daniel P DonatoMatthew T JohnsonXiming J YangDebra L Zynger Source Type: research

Fine needle aspiration cytology of Sertoli–Leydig cell tumors of ovary masquerading as dysgerminoma
AbstractHerein, we described a case of a 29‐year‐old female with a large ovarian mass. Fine needle aspiration cytology (FNAC) of the mass showed discrete round to oval cells in a fatty vacuolated background. FNAC diagnosis of dysgerminoma was suggested. The histology of the tumors showed features of poorly differentiated Sertoli–Leydig cell tumors. We discussed the diagnostic pitfalls of this case on FNAC. Diagn. Cytopathol. 2011. © 2011 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 18, 2011 Category: Pathology Authors: Sandeep Kumar Arora, Pranab Dey Tags: Brief Report Source Type: research

Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes
Conclusions: These findings suggest that GPER could mediate estrogen signaling in both normal and transformed somatic cells of human testis, but they reveal a differential expression of the novel estrogen receptor in non neoplastic and neoplastic germ cells. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 5, 2011 Category: Endocrinology Authors: Vittoria RagoFrancesco RomeoFrancesca GiordanoMarcello MaggioliniAmalia Carpino Source Type: research

Ameliorative effects of curcumin on the structural parameters of seminiferous tubules and Leydig cells in metronidazole-treated mice: A stereological approach.
Abstract Metronidazole (MTZ), an anti-parasitic drug, induces negative effects on the testis. Curcumin exhibits antioxidant properties and anti-tumor properties. The aim was to evaluate negative effects of seminiferous tubules and Leydig cells by MTZ and ameliorative effects of curcumin. Balb/c mice were divided into six groups. The control, second, third, fourth and fifth, and sixth groups were administrated distilled water, high doses of MTZ (500mg/kg/day), MTZ (500mg/kg/day) +100mg/kg/day curcumin, therapeutic doses of MTZ (165mg/kg/day), MTZ (165mg/kg/day) +100mg/kg/day curcumin, and 100mg/kg/day curcumin, resp...
Source: Experimental and Toxicologic Pathology - October 1, 2011 Category: Pathology Authors: Noorafshan A, Karbalay-Doust S, Valizadeh A, Aliabadi E Tags: Exp Toxicol Pathol Source Type: research

Finasteride‐related Leydig cell tumour: report of a case and literature review
SummaryLeydig cell tumours (LCTs) of the testis are rare. Their origin is still unknown. This case report describes a potential relationship between LCT and prolonged exposure to Finasteride. (Source: Andrologia)
Source: Andrologia - September 26, 2011 Category: Urology & Nephrology Authors: D. Berthold, B. Lhermitte, M. Uffer, A. Doerfler Tags: CASE REPORT Source Type: research

Management of metastatic ovarian Sertoli–Leydig cell tumor with sporadic multinodular goiter: a case report and literature review
Future Oncology , September 2011, Vol. 7, No. 9, Pages 1113-1117. (Source: Future Oncology)
Source: Future Oncology - September 15, 2011 Category: Cancer & Oncology Tags: article Source Type: research

Metachronous contralateral Leydig-cell tumour in an 8-year-old boy
Abstract: Leydig-cell tumours of the testis are rare and usually benign in children. The possibility of metachronous bilateral tumours should be considered not only for testicular teratomas but also in the follow up of a Leydig-cell tumour. Testis-sparing surgery is feasible and safe in prepubertal boys after exclusion of a malignant tumour. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - September 9, 2011 Category: Urology & Nephrology Authors: A. D’Alessio, E. Piro, M. Brugnoni, L. Abati, A. Assi Tags: Case Reports (online only) Source Type: research

Extending the Phenotypes Associated with DICER1 Mutations
We report DICER1 mutations in seven additional families who manifested uterine cervix embryonal rhabdomyosarcoma (cERMS, four cases) and primitive neuroectodermal tumor (cPNET, one case), Wilms tumor (WT, three cases), pulmonary sequestration (PS) (one case) and juvenile intestinal polyp (one case). One carrier developed (age 25 years) a pleomorphic sarcoma of the thigh; another carrier had transposition of great arteries (TGA). These observations show that cERMS, cPNET, WT, PS and juvenile polyps fall within the spectrum of DICER1‐related diseases. DICER1 appears to be the first gene implicated in the etiology of cERMS,...
Source: Human Mutation - August 30, 2011 Category: Genetics & Stem Cells Authors: William D. FoulkesAmin BahubeshiNancy HamelBarbara PasiniSofia AsioliGareth BaynamCatherine S. ChoongAdrian CharlesRichard P. FriederMegan K. DishopNicole GrafMesiha EkimDorothée Bouron‐Dal SoglioJocelyne ArseneauRobert H. YoungNelly SabbaghianArchana Tags: Brief Report Source Type: research

Fine needle aspiration cytology in ovarian lesions: an institutional experience of 584 cases
Conclusion: FNAC has a high specificity for diagnosis of ovarian/adnexal lesions but greater experience is required for the accurate subtyping of neoplasms and sensitivity is limited by inconclusive/inadequate results. (Source: Cytopathology)
Source: Cytopathology - August 25, 2011 Category: Pathology Authors: N. Gupta, A. Rajwanshi, L. K. Dhaliwal, N. Khandelwal, P. Dey, R. Srinivasan, R. Nijhawan Source Type: research

Cervical sarcoma botryoides and ovarian Sertoli–Leydig cell tumor: a case report and review of literature
Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-011-2017-4Authors P. Rosenberg, Unit of Gynecology, European Institute of Oncology, Via Ripamonti, 239, Milan, ItalyS. Carinelli, Unit of Gynecology, European Institute of Oncology, Via Ripamonti, 239, Milan, ItalyM. Peiretti, Unit of Gynecology, European Institute of Oncology, Via Ripamonti, 239, Milan, ItalyV. Zanagnolo, Unit of Gynecology, European Institute of Oncology, Via Ripamonti, 239, Milan, ItalyA. Maggioni, Unit of Gynecology, European Institute of Oncology, Via Ripamonti, 239, Milan, Italy Journal Archives of Gynecol...
Source: Archives of Gynecology and Obstetrics - August 17, 2011 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Cytologic, Immunocytologic, Histopathologic and Immunohistologic Diagnosis of the Poorly Differentiated Sertoli-Leydig Cell Tumor
Acta Cytologica 2011;55:382–386 (DOI:10.1159/000327906) (Source: Karger Publishers)
Source: Karger Publishers - July 21, 2011 Category: Cancer & Oncology Source Type: research

Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen‐dependent mechanism involving IGF‐I system
In this study we aimed to determine if nandrolone and stanozolol, two commonly used AAS, could have an effect on Leydig cell tumor proliferation and if their effects could be potentiated by the concomitant use of IGF‐I. Using a rat Leydig tumor cell line, R2C cells, as experimental model we found that nandrolone and stanozolol caused a dose‐dependent induction of aromatase expression and estradiol (E2) production. When used in combination with IGF‐I they were more effective than single molecules in inducing aromatase expression. AAS exhibited estrogenic activity and induced rapid estrogen receptor (ER)‐dependent pa...
Source: Journal of Cellular Physiology - July 17, 2011 Category: Cytology Authors: Adele ChimentoRosa SirianniFabiana ZoleaArianna De LucaMarilena LanzinoStefania CatalanoSebastiano AndòVincenzo Pezzi Tags: Original Research Article Source Type: research

The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells
In conclusion, cordycepin could activate adenosine subtype receptors and simultaneously induce steroidogenesis and apoptosis in MA-10 mouse Leydig tumor cells. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - June 5, 2011 Category: Allergy & Immunology Source Type: research

Histopathological and immunophenotypic features of testicular tumour of the adrenogenital syndrome
Conclusions: In addition to clinical information, biochemical profile and histopathological findings, our results suggest that immunohistochemistry using a panel of antibodies including CD56, synaptophysin and androgen receptor is helpful in differentiating TTAGS from LCT. (Source: Histopathology)
Source: Histopathology - May 31, 2011 Category: Pathology Authors: Zhuo WangShicong YangHuijuan ShiHong DuLing XueLiantang WangYu DongAnjia Han Source Type: research

Increased incidence of Leydig cell tumours of the testis in the era of improved imaging techniques
CONCLUSION• The percentage of LCT (14.7% of all testicular tumours removed) was significantly higher than expected from the literature. One possible explanation for this phenomenon is the increasing use of better ultrasound technology and the subsequent increased detection of small nodules that have not been found in historical series. Use of ‘observation‐only’ for very small lesions detected at infertility clinics is under debate. (Source: BJU International)
Source: BJU International - May 31, 2011 Category: Urology & Nephrology Authors: Nicolai LeonhartsbergerReinhold RamonerFriedrich AignerBrigitte StoehrRenate PichlerFlorian ZangerlAndreas FritzerHannes Steiner Source Type: research