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Primary Intracranial Extra-Axial and Supratentorial Atypical Rhabdoid TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on magnetic resonance imaging findings of a 22-month-old boy with a biopsy-proven primary rhabdoid tumor, presenting as a single intracranial supratentorial extra-axial mass. Based on the patient's age and imaging features (perfusion, diffusion magnetic resonance imaging, and magnetic resonance spectroscopy), a diagnosis of atypical teratoid/rhabdoid tumor was more accurate than diagnoses of meningioma and primitive neuroectodermal tumor. Although this entity is relatively rare, it should be considered in the differential diagnosis of dural-based, space-occupying central nervous system lesions. (Source: Pediatric Neurology)
Source: Pediatric Neurology - November 20, 2009 Category: Neurology Authors: Fabrice Bing, Frédérique Nugues, Sylvie Grand, Pierre Bessou, Caroline Salon Tags: Case Reports Source Type: journals

Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Primary neuroendocrine tumors of the gallbladder (GB) and extrahepatic biliary ducts (EHBDs) include carcinoid tumors and small-cell carcinomas (SCCs). They are uncommon, and therefore, little is known about their demographics and clinical course. From National Cancer Institute's Surveillance, Epidemiology, and End Results program (1973-2005), we analyzed the demographics and 10-year relative survival rates of carcinoids and SCCs of the GB and EHBD according to histologic type and stage. There were 119 cases of carcinoid tumors and 54 cases of SCCs in the GB. There were 31 carcinoid tumors and 17 SCCs in the EHBD...
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Authors: Jorge Albores-Saavedra, Kristen Batich, Sarah Hossain, Donald E. Henson, Arnold M. Schwartz Tags: Original Contributions Source Type: journals

Goldhirsh Foundation 2010 Grant Cycle of the Brain Tumor Research Awards ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Goldhirsh Foundation is pleased to announce the 2010 Grant Cycle of the Brain Tumor Research Awards Program. The next application deadline is Thursday, January 7, 2010, 12:00 Noon, U.S. and Canada Eastern Time (GMT-5) for awards beginning on July 1, 2010. The Goldhirsh Foundation was established by Bernard A. Goldhirsh in 2000, shortly after he was diagnosed with brain cancer. Since his death in 2003, the Board of Directors of the Foundation (which includes his two children) has been shaping a grantmaking program that reflects his values and entrepreneurial spirit. We are dedicated to making a difference in the lives ...
Source: ScanGrants feed - November 15, 2009 Category: Research Authors: Goldhirsh Foundation Source Type: funding

Soft tissue sarcomas with complex genomic profilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurr...
Source: Virchows Archiv - November 12, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challengeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma. Pathological assessment on a pre-operative bioptical specimen showed an immature teratoid tumor with no area of hepatoblastic differentiation present. Histological and immunhistological examination of the resected tumor specimen additionally showed tumor areas of very different differentiation pattern intermixed with each other, namely areas of hepatoblastoma-typical and neuroblastoma-like morphology as well a areas of rhadomy...
Source: Diagnostic Pathology - November 12, 2009 Category: Pathology Authors: Alexander MollAlexander KrenauerUta BierbachHolger TillWolfgang HirschIvo LeuschnerNicole SchmitzChristian WittekindThomas Aigner Source Type: journals

Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH) : revealing significant overlapping genomic lesions with diffuse large B-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: To the best of our knowledge, the current study represents the first genomic exploration of PL. The genomic aberration pattern of PL appears to be more similar to that of DLBCL (AIDS-related or non AIDS-related) than to PCM. Our findings suggest that PL may remain best classified as a subtype of DLBCL at least at the genome level. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 12, 2009 Category: Hematology Authors: Chung-Che ChangXiaobo ZhouJesalyn TaylorWan-Ting HuangXianwen RenFederico MonzonYongdong FengPulivarthi RaoXinYan LuFacchetti FabioSusan HilsenbeckChad CreightonElaine JaffeChing-Ching Lau Source Type: journals

A twisted kiss: in vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, altered nucleotide sequence and repression of transcription are two potential mechanisms of suppression of the anti-metastatic effects of KiSS1 in early breast cancer: Confirmation in larger cohorts and study of functional effects of the 242C>G exon IVa mutation are warranted. Keywords: KiSS1, metastasis-suppressor gene, breast cancer, mutation, transcription. PMID: 19895172 [PubMed - in process] (Source: Neoplasma)
Source: Neoplasma - November 11, 2009 Category: Cancer & Oncology Authors: Pentheroudakis G, Kostadima L, Dova L, Georgiou I, Tzavaras T, Vartholomatos G, Wirtz RM, Fountzilas G, Malamou-Mitsi V, Pavlidis N Tags: neoplasma Source Type: journals

Etiologic factors in testicular germ-cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Oncology , November 2009, Vol. 5, No. 9, Pages 1389-1402. (Source: Future Oncology)
Source: Future Oncology - November 10, 2009 Category: Cancer & Oncology Tags: article Source Type: journals

Potential effects of the herbicide Diuron on mammary and urinary bladder two-stage carcinogenesis in a female Swiss mouse model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The potential promoting effect of Diuron was investigated in a mouse model of mammary and urinary bladder carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Four-week old female Swiss mice were allocated to five groups: Groups G1-G3 received DMBA (5 x 1.5 mg/mouse) and BBN (8 x 7.5 mg/mouse) and G4 and G5 groups received only vehicles during the first 6 weeks. At week 7, G1 and G5 groups received basal diet and G2, G3 and G4 groups were fed a diet containing Diuron at 1,250, 2,500 and 2,500 ppm, respectively, during 13 weeks. At week 20, the animals were eut...
Source: Archives of Toxicology - November 10, 2009 Category: Toxicology Authors: de Moura NA, Grassi TF, Rodrigues MA, Barbisan LF Tags: Arch Toxicol Source Type: journals

Comparison of Beta-catenin with TGF-beta1, HIF-1alpha and Patients' Disease-free Survival in Human Colorectal Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Beta-catenin accumulation is suppressed by TGF-beta1 (transforming growth factor beta1) in intestinal epithelium suggesting negative feedback between these two factors. Besides that, beta-catenin interacts with HIF-1alpha (hypoxia-inducible factor-1alpha) at the promoter region of HIF-1 target genes. Our study was aimed at comparison of beta-catenin with HIF-1alpha, TGF-beta1, Ki67 and survival of sporadic colorectal cancer patients. Expressions of beta-catenin, TGF-beta1, HIF-1alpha, Ki67 were evaluated in triads of specimens of each primary tumor of 72 sporadic colorectal cancers with immunohistochemistry due to limi...
Source: Pathology Oncology Research - November 8, 2009 Category: Pathology Authors: Wincewicz A, Koda M, Sulkowski S, Kanczuga-Koda L, Sulkowska M Tags: Pathol Oncol Res Source Type: journals

Molecular targeted therapies in the treatment of gastroenteropancreatic neuroendocrine tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Gastroenteropancreatic neuroendocrine tumors (GEPNETs) are rare neoplasms that require a multidisciplinary approach for an optimal management. The traditional cytotoxic agents are of limited efficacy in the treatment of these tumors. A better understanding of the molecular pathways that characterize tumor growth has provided novel targets in cancer treatment. Several proteins have been implicated as having a crucial role in GEPNETs. Several proangiogenic molecules are overexpressed in GEPNETs including vascular endothelial growth factor (VEGF) and its receptors, and related signaling pathway compone...
Source: Targeted Oncology - November 6, 2009 Category: Cancer & Oncology Tags: Targeted Oncology Source Type: journals

Targeted disruption of S100P suppresses tumor cell growth by down-regulation of cyclin D1 and CDK2 in human hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study showed over-expression of S100P in HCC. The aberrant regulation of S100P in HCC might activate cyclin D1 and CDK expression and contribute to the mitogenic potential of tumor cells during HCC carcinogenesis. These findings provide information that suggests new therapeutic strategies for the treatment of liver cancer. PMID: 19885547 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Kim JK, Jung KH, Noh JH, Eun JW, Bae HJ, Xie HJ, Ahn YM, Ryu JC, Park WS, Lee JY, Nam SW Tags: Int J Oncol Source Type: journals

Assessment of angiogenesis by CD105 antigen in epithelial salivary gland neoplasms with diverse metastatic behaviorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Immunostaining of CD105 in salivary gland tumors imply participation of angiogenesis in the development of malignant lesions, as well as some role for myoepithelial cells in the control of new vessel formation. In addition, suggest that ACC with positive CD105 vessels are at higher risk for metastasis. (Source: BMC Cancer)
Source: BMC Cancer - November 4, 2009 Category: Cancer & Oncology Authors: Sergio CardosoKelen Christine SouzaPaulo Rogerio FariaAna Lucia EisenbergFernando DiasAdriano Loyola Source Type: journals

Thin-layer cytopathology of a gastrointestinal stromal tumor (GIST) in effusion: diagnostic dilemmas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although gastrointestinal stromal tumors (GISTs) are uncommon, they represent the most frequent mesenchymal neoplasms of the gastrointestinal tract. During recent years, considerable information has been published about the pathogenesis, molecular biology, histological criteria, surgery, and adjuvant pharmacological treatment of GISTs, but there have been few reports about the cytologic diagnosis of GISTs, particularly in effusions; in such specimens these neoplasms cause a wide range of potential pitfalls. In this case report, we show that by combining morphological and immunocytochemical studies on thin layer slide p...
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: Zappacosta R, Caraceni D, Stura S, Zappacosta B, Rosini S Tags: Ann Clin Lab Sci Source Type: journals

Pancreatic head resection with segmental duodenectomy for pancreatic neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Total resection of the pancreatic head can be performed safely and effectively by this procedure. Content Type Journal ArticleCategory TopicsDOI 10.1007/s00534-009-0223-2Authors Akimasa Nakao, Nagoya University Graduate School of Medicine Department of Surgery II 65 Tsurumai-cho Showa-ku Nagoya 466-8550 JapanShin Takeda, Nagoya University Graduate School of Medicine Department of Surgery II 65 Tsurumai-cho Showa-ku Nagoya 466-8550 JapanShuji Nomoto, Nagoya University Graduate School of Medicine Department of Surgery II 65 Tsurumai-cho Showa-ku Nagoya 466-8550 JapanNaohito Kanazumi, Nagoya Uni...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - November 3, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

ForewordEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although there have been remarkable advances in the diagnosis and treatment of breast cancer, this disease continues to represent the leading cause of cancer death in premenopausal women. In this issue of Current Problems in Surgery, Dr. John Vetto and his colleagues at the Oregon Health & Sciences University have written a masterful overview entitled, “Breast Cancer in Premenopausal Women.” Beginning with a discussion of advances in our understanding of pathogenesis, genetics and tumor biology, the monograph provides state of the art information on screening, diagnosis, and the increasingly multidisciplinary managemen...
Source: Current Problems in Surgery - November 2, 2009 Category: Surgery Authors: Stanley W. Ashley Source Type: journals

Flow Cytometric Detection of Small Cell Lung Cancer Cells with Aberrant CD45 Expression in Micrometastatic Bone MarrowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe this rare case to arouse an attention that tumors of non-hematolymphoid origin can exhibit exceptional CD45-positvity in metastatic sites. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Danbara, M., Yoshida, M., Kanoh, Y., Jiang, S.-X., Masuda, N., Akahoshi, T., Higashihara, M. Tags: Short Communications Source Type: journals

SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma. PMID: 19880778 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Mozos A, Royo C, Hartmann E, De Jong D, Baró C, Valera A, Fu K, Weisenburger DD, Delabie J, Chuang SS, Jaffe ES, Ruiz-Marcellan C, Dave S, Rimsza L, Braziel R, Gascoyne RD, Solé F, López-Guillermo A, Colomer D, Staudt LM, Rosenwald A, Ott G Tags: Haematologica Source Type: journals

A case of malignant abdominal pain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The differential diagnosis of atypical abdominal pain in young men should include testicular tumors. A thorough testicular exam should be part of the routine physical exam in such situations. PMID: 19887871 [PubMed - in process] (Source: Onkologie)
Source: Onkologie - November 1, 2009 Category: Cancer & Oncology Authors: Sah RP, Anaparthy R, Sugumar A Tags: Onkologie Source Type: journals

Cystic Lymphangioma-like Adenomatoid Tumor of the Adrenal Gland: Case Presentation and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adenomatoid tumors (AT) are usually found in the genital tract of both sexes. They are very rarely located in extragenital sites, and are exceedingly rare in the adrenal. AT of the adrenal gland (AT-AG) are nonfunctioning, usually discovered incidentally and confused on imaging with other more common adrenal neoplasms. The overwhelming majority occur in males. Thirty-four cases have been reported so far, more often presenting grossly as solid tumors, rarely as solid with cystic areas, and 5 cases were almost entirely cystic. At histology they can be either circumscribed or locally infiltrative, and may pose diagnostic diff...
Source: Advances in Anatomic Pathology - November 1, 2009 Category: Pathology Tags: AMR Series Source Type: journals

Germinoma in the basal ganglia with an abnormal karyotype: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Intracranial germinoma, a potentially curable tumor, should be considered in children with nonspecific neurological symptoms, endocrinologic changes, and ipsilateral cerebral hemiatrophy on computed tomography or magnetic resonance. Investigation of chromosomal aberrations in those patients would clarify the tumorigenesis and lead to possibilities for novel disease-specific therapies. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00381-009-1007-3Authors En Xu, The Second Affiliated Hospital of Guangzhou Medical College Institute of Neurosciences 250 Changgang Dong RD Guangzh...
Source: Child's Nervous System - October 30, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Treatment and differential diagnosis of aneurysmal bone cyst based on our own experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Aneurysmal bone cyst was first described by Jaffe and Lichtenstein in 1942. Schajowicz in 1972 in his Histopathological Classification of Primary Bone Tumors (later modified by WHO in 1993) placed it in group IX - tumor-like lesions. Its etiology and pathogenesis is not completely clear. Aneurysmal bone cysts are usually found in older children and young adults, rarely before the age of 5 or after 30.<br /> The aim of the study is to evaluate aneurysmal cyst treatment outcomes in patients we have treated and present diagnostic difficulties, especially considering the giant cell tumor in differential d...
Source: Ortopedia, Traumatologia, Rehabilitacja - October 30, 2009 Category: Orthopaedics Authors: Tomasik P, Spindel J, Miszczyk L, Chrobok A, Koczy B, Widuchowski J, Mrożek T, Matysiakiewicz J, Pilecki B Tags: Ortop Traumatol Rehabil Source Type: journals

Identification and Validation of a Gene Expression Signature That Predicts Outcome in Adult Men With Germ Cell Tumors [Genitourinary Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We have identified gene expression signatures that accurately predict outcome in patients with GCTs. These predictive genes should be useful for the prediction of patient outcome and could provide novel targets for therapeutic intervention. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Korkola, Houldsworth, Feldman, Olshen, Qin, Patil, Reuter, Bosl, Chaganti Tags: Prognostic Studies, Translational Oncology Genitourinary Cancer Source Type: journals

Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal ModelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we identified and confirmed an important role for the PI3K/AKT pathway in the development of urothelial carcinoma and suggested that inhibitors of this pathway (e.g., mTOR inhibitor) may serve as effective therapeutic agents. [Cancer Res 2009;69(21):8256–64] (Source: Cancer Research)
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Qian, C.-N., Furge, K. A., Knol, J., Huang, D., Chen, J., Dykema, K. J., Kort, E. J., Massie, A., Khoo, S. K., Vanden Beldt, K., Resau, J. H., Anema, J., Kahnoski, R. J., Morreau, H., Camparo, P., Comperat, E., Sibony, M., Denoux, Y., Molinie, V., Vieille Tags: Cell, tumor, and Stem Cell Biology Source Type: journals

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: During induced differentiation of human EC cells, the Wnt signalling pathway is reprogrammed and canonical Wnt signalling induced. Specific species regulating non-canonical Wnt signalling conferred growth inhibition when targeted for repression in these EC cells. Notably, FZD7 repression significantly inhibited growth of human EC cells and is a promising therapeutic target for TGCTs. (Source: BMC Cancer)
Source: BMC Cancer - October 29, 2009 Category: Cancer & Oncology Authors: Grace SnowAllison KasperAlexander BuschElisabeth SchwarzKatherine EwingsThomas BeeMichael SpinellaEthan DmitrovskySarah Freemantle Source Type: journals

Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to assess the risk of patients being exposed to an anti-AIDS medication contaminated with EMS we have performed in depth genotoxicity, general toxicity and DMPK investigations. The results of these studies are reported in the accompanying papers of this issue. Prior to starting our investigations we searched the literature for toxicity data on this well established mutagen with specific attention to dose-response relations in in vivo genotoxicity studies, since, obviously, in vivo data are pivotal for risk assessment. There are numerous published in vivo genotoxicity studies on EMS, with generally 50mg/kg - or...
Source: Toxicology Letters - October 28, 2009 Category: Toxicology Authors: Gocke E, Bürgin H, Müller L, Pfister T Tags: Toxicol Lett Source Type: journals

Successful salvage high-dose chemotherapy and autologous stem-cell transplantation in HIV-related germ-cell tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Oncology)
Source: Annals of Oncology - October 27, 2009 Category: Cancer & Oncology Authors: Hentrich, M., Schiel, X., Niedermeier, A., Lutz, L., Rupec, R., Stief, C., Bogner, J., Karthaus, M., Gerl, A. Tags: letters to the editor Source Type: journals

ORIGINAL CONTRIBUTION: Risk of Pancreatic Cancer in Families With Lynch SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Among 147 families with germline MMR gene mutations, the risk of pancreatic cancer was increased compared with the US population. Individuals with MMR gene mutations and a family history of pancreatic cancer are appropriate to include in studies to further define the risk of premalignant and malignant pancreatic neoplasms and potential benefits and limitations of surveillance. (Source: JAMA)
Source: JAMA - October 27, 2009 Category: Journals (General) Authors: Kastrinos, F., Mukherjee, B., Tayob, N., Wang, F., Sparr, J., Raymond, V. M., Bandipalliam, P., Stoffel, E. M., Gruber, S. B., Syngal, S. Tags: Oncology, Colon Cancer, Oncology, Other, Gastroenterology, Gastrointestinal Diseases, Liver/ Biliary Tract/ Pancreatic Diseases, Genetics, Genetic Disorders Original Contribution Source Type: journals

Solitary fibrous tumors of the pleura: an analysis of 110 patients treated in a single institution.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Solitary fibrous tumor of the pleura is a rare disease that includes both benign and malignant variants.The outcome is mostly benign, with an overall 10-year survival rate of 97.5%. Pathologically benign lesions show a better disease-free survival rate than malignant lesions (95.7% versus 67.1%; p < 0.05). Surgery is the gold standard of treatment as neither radiotherapy nor chemotherapy proved to be effective. PMID: 19853123 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 27, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Cardillo G, Carbone L, Carleo F, Masala N, Graziano P, Bray A, Martelli M Tags: Ann Thorac Surg Source Type: journals

Erratum to: Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00432-009-0697-yAuthors Karin Oechsle, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyCarsten Bokemeyer, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyFriedemann Honecker, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg Germany Journal Journal of Cancer ...
Source: Journal of Cancer Research and Clinical Oncology - October 26, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Classification of brain tumor type and grade using MRI texture and shape in a machine learning schemeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to investigate the use of pattern classification methods for distinguishing different types of brain tumors, such as primary gliomas from metastases, and also for grading of gliomas. The availability of an automated computer analysis tool that is more objective than human readers can potentially lead to more reliable and reproducible brain tumor diagnostic procedures. A computer-assisted classification method combining conventional MRI and perfusion MRI is developed and used for differential diagnosis. The proposed scheme consists of several steps including region-of-interest definition, feat...
Source: Magnetic Resonance in Medicine - October 26, 2009 Category: Radiology Authors: Evangelia I. Zacharaki, Sumei Wang, Sanjeev Chawla, Dong Soo Yoo, Ronald Wolf, Elias R. Melhem, Christos Davatzikos Source Type: journals

High-frequency mode conversion technique for stiff lesion detection with magnetic resonance elastography (MRE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel imaging technique is described in which the mode conversion of longitudinal waves is used for the qualitative detection of stiff lesions within soft tissue using magnetic resonance elastography (MRE) methods. Due to the viscoelastic nature of tissue, high-frequency shear waves attenuate rapidly in soft tissues but much less in stiff tissues. By introducing minimally-attenuating longitudinal waves at a significantly high frequency into tissue, shear waves produced at interfaces by mode conversion will be detectable in stiff regions, but will be significantly attenuated and thus not detectable in the surrounding soft...
Source: Magnetic Resonance in Medicine - October 26, 2009 Category: Radiology Authors: Yogesh K. Mariappan, Kevin J. Glaser, Armando Manduca, Anthony J. Romano, Sudhakar K. Venkatesh, Meng Yin, Richard L. Ehman Source Type: journals

Classification of brain tumor type and grade using MRI texture and shape in a machine learning scheme.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to investigate the use of pattern classification methods for distinguishing different types of brain tumors, such as primary gliomas from metastases, and also for grading of gliomas. The availability of an automated computer analysis tool that is more objective than human readers can potentially lead to more reliable and reproducible brain tumor diagnostic procedures. A computer-assisted classification method combining conventional MRI and perfusion MRI is developed and used for differential diagnosis. The proposed scheme consists of several steps including region-of-interest definition, feat...
Source: Magnetic Resonance in Medicine - October 26, 2009 Category: Radiology Authors: Zacharaki EI, Wang S, Chawla S, Soo Yoo D, Wolf R, Melhem ER, Davatzikos C Tags: Magn Reson Med Source Type: journals

High-frequency mode conversion technique for stiff lesion detection with magnetic resonance elastography (MRE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel imaging technique is described in which the mode conversion of longitudinal waves is used for the qualitative detection of stiff lesions within soft tissue using magnetic resonance elastography (MRE) methods. Due to the viscoelastic nature of tissue, high-frequency shear waves attenuate rapidly in soft tissues but much less in stiff tissues. By introducing minimally-attenuating longitudinal waves at a significantly high frequency into tissue, shear waves produced at interfaces by mode conversion will be detectable in stiff regions, but will be significantly attenuated and thus not detectable in the surrounding ...
Source: Magnetic Resonance in Medicine - October 26, 2009 Category: Radiology Authors: Mariappan YK, Glaser KJ, Manduca A, Romano AJ, Venkatesh SK, Yin M, Ehman RL Tags: Magn Reson Med Source Type: journals

Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data suggest alterations in Bcl-2 expression and lymphocyte infiltration correlate with epithelial ovarian cancer progression. Consequently, Bcl-2 expression and lymphocyte status may be important for prognostic outcome or useful targets for therapeutic intervention. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 25, 2009 Category: Cancer & Oncology Authors: Nicole AndersonLeslie TurnerSandra LivingstonRen ChenSanto NicosiaPatricia Kruk Source Type: journals

Salvage chemotherapy with paclitaxel and gemcitabine plus nedaplatin (TGN) as part of multidisciplinary therapy in patients with heavily pretreated cisplatin-refractory germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The TGN regimen alone had limited efficacy in this patient population, with severe but manageable toxicities. However, TGN chemotherapy may offer a chance of cure for some heavily pretreated cisplatin-refractory (TIP/TIN-refractory) patients as part of multidisciplinary therapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-009-0899-yAuthors Takumi Shiraishi, Kyoto Prefectural University of Medicine Department of Urology, Graduate School of Medical Science Kawaramachi-Hirokoji, Kamigyo-ku Kyoto 602-8566 JapanTerukazu Nakamura, Kyoto Prefectural University of Medici...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

The World Health Organization (WHO) Classification of Tumors of the Hematopoietic and Lymphoid Tissues: An overview with emphasis on the myeloid neoplasms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The World Health Organization (WHO) classification of myeloid and lymphoid neoplasms utilizes morphology, immunophenotype, genetics and clinical features to define disease entities of clinical significance. It is a consensus classification in which a number of experts have agreed on the classification and diagnostic criteria. In general, the classification stratifies neoplasms according to their lineage (myeloid, lymphoid, histiocytic/dendritic) and distinguishes neoplasms of precursor cells from those comprised of functionally mature cells. Lymphoid neoplasms are derived from cells that frequently have features that r...
Source: Chemico-Biological Interactions - October 23, 2009 Category: Molecular Biology Authors: Vardiman JW Tags: Chem Biol Interact Source Type: journals

Solitary Fibrous Tumors of the Pleura: An Analysis of 110 Patients Treated in a Single Institution [ORIGINAL ARTICLES: GENERAL THORACIC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Solitary fibrous tumor of the pleura is a rare disease that includes both benign and malignant variants.The outcome is mostly benign, with an overall 10-year survival rate of 97.5%. Pathologically benign lesions show a better disease-free survival rate than malignant lesions (95.7% versus 67.1%; p < 0.05). Surgery is the gold standard of treatment as neither radiotherapy nor chemotherapy proved to be effective. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 22, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Cardillo, G., Carbone, L., Carleo, F., Masala, N., Graziano, P., Bray, A., Martelli, M. Tags: Pleura ORIGINAL ARTICLES: GENERAL THORACIC Source Type: journals

Clinicopathological analysis of primary epithelial appendiceal neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the clinicopathologic presentation and outcome of patients with appendiceal tumors treated at our institution over a 15-year period. We identified patients with appendiceal tumors diagnosed or treated at our institution from January 1989 through May 2004. Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed. Review of the pathologic specimens was performed and tumors were classified as DPAM, PMCA I/D, or PMCA. Forty patients were identified (median age 52.5 years; males 38%). The number of patients with DPAM, PMCA I/D, and PMCA was ...
Source: Medical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Genetic testing in orbital tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
OBJECTIVE: This review aims to discuss the clinical application of cytogenetic and molecular testing in the diagnosis and prognosis of orbital tumors and, in so doing, highlight the basis of these methods, their advantages, and limitations. SUMMARY: Specific chromosomal aberrations are detected in many lymphoproliferative neoplasms, soft tissue tumors, and in a few benign tumors of the orbit. Detection of these characteristic chromosomal translocations is most helpful to refine the diagnosis and classification, especially when the tumor is poorly differentiated and shows overlapping morphological features with another ...
Source: Orbit - October 22, 2009 Category: Opthalmology Authors: Khong JJ, Moore S, Prabhakaran VC, Selva D Tags: Orbit Source Type: journals

Family history of cancer and malignant germ cell tumors in children: A report from the Children’s Oncology GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Family history of testicular cancer is an established risk factor for adult testicular germ cell tumors (GCT). We evaluated the association between family history of cancer and pediatric GCT in a Children’s Oncology Group case–control study that included 274 GCT cases (195 female and 79 male) diagnosed <age 15 years and 418 controls frequency matched to cases on sex and age. Family history data were collected through telephone interviews with biological mothers and fathers and unconditional logistic regression was used to evaluate associations with GCT adjusting for potential confounders...
Source: Cancer Causes and Control - October 21, 2009 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: journals

NK cell lymphoblastic lymphoma in the masticator space: a case of non-Hodgkin lymphoma with challenging maxillofacial manifestation and immunophenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report discusses diagnostic challenges of NHL, including manifestation of numb chin syndrome as a clinical indicator and immunophenotyping of NK-cell–lineage neoplasms. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - October 21, 2009 Category: ENT & OMF Authors: Tomoaki Imai, Masahiro Michizawa, Hiroyuki Degami Tags: Oral Medicine Source Type: journals

Malignant solitary fibrous tumor arising from the pineal region: case study and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of malignant solitary fibrous tumor involving the pineal region in a 49-year-old woman. The patient presented with headache, slowly progressive weakness of the right lower extremities and upgaze palsy over the past year. Histologically, the tumor was composed of moderately hypercellular proliferated spindle cells with eosinophilic collagen bands. These cells were diffusely and strongly immunoreactive with CD34, CD99, and vimentin, but were negative with epithelial membrane antigen, S-100 protein, Bcl-2, smooth muscle actin, cytokeratin and glial fibrillary antigenic protein. MIB-1 labeling indices and mito...
Source: Neuropathology - October 20, 2009 Category: Neurology Authors: Jing Zhang, Hong Cheng, Qing Qiao, Jing-Song Zhang, Ying-Mei Wang, Xin Fu, Qing Li Source Type: journals

MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Monitoring Editor: Richard K. Assoian The c-Myc promoter binding protein 1 (MBP-1) is a transcriptional suppressor of c-myc expression and involved in control of tumorigenesis. Gastric cancer is one of the most frequent neoplasms and lethal malignancies worldwide. So far, the regulatory mechanism of its aggressiveness has not yet been clearly characterized. Here we studied roles of MBP-1 in gastric cancer progression. We found that cell proliferation was inhibited by MBP-1 overexpression in human stomach adenocarcinoma SC-M1 cells. Colony formation, migration, and invasion abilities of SC-M1 cells were suppressed by MB...
Source: Mol Biol Cell - October 20, 2009 Category: Molecular Biology Authors: Hsu KW, Hsieh RH, Wu CW, Chi CW, Lee YH, Kuo ML, Wu KJ, Yeh TS Tags: Mol Biol Cell Source Type: journals

A Review of the Molecular Mechanisms of Chemically Induced Neoplasia in Rat and Mouse Models in National Toxicology Program Bioassays and Their Relevance to Human Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor response in the B6C3F1 mouse, F344 rat, and other animal models following exposure to various compounds provides evidence that people exposed to these or similar compounds may be at risk for developing cancer. Although tumors in rodents and humans are often morphologically similar, underlying mechanisms of tumorigenesis are often unknown and may be different between the species. Therefore, the relevance of an animal tumor response to human health would be better determined if the molecular pathogenesis were understood. The underlying molecular mechanisms leading to carcinogenesis are complex and involve multiple ...
Source: Toxicologic Pathology - October 20, 2009 Category: Pathology Authors: Hoenerhoff MJ, Hong HH, Ton TV, Lahousse SA, Sills RC Tags: Toxicol Pathol Source Type: journals

Histological heterogeneity of Ewing’s sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical supportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the diagnosis of atypical ES is a challenge for the pathologist and needs support from molecular techniques to perform an optimal differential diagnosis with other small round cell tumors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00428-009-0842-7Authors Antonio Llombart-Bosch, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainIsidro Machado, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainSamuel Navarro, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainF...
Source: Virchows Archiv - October 20, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Two cases of intracranial germinoma showing a cell arrangement mimicking carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of intracranial germinoma, in which it was necessary to distinguish between intracranial germinoma and metastatic carcinoma in cytological specimens. Cytologically, not only single tumor cells or loosely connective tumor cells but also closely packed clusters of cells and pair cells were recognized. Immunocytochemically, almost all tumor cells were immunoreactive for M2A, placental alkaline phosphatase, and c-kit. Closely packed clusters were also immunoreactive for pan-cytokeratin. Therefore, Cytopathologists should be aware that tumor cell clusters, mimicking carcinoma might appear in cytological spec...
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: Yoshiki Ohta, Takao Suzuki, Takahiko Tonoike, Shigeharu Hamatani, Nobuyuki Ohike, Akira Shiokawa, Miki Kushima, Hidekazu Ota Source Type: journals

ORIGINAL ARTICLE: Decompression of the Orbital Apex: An Alternate Approach to Surgical Excision for Radiographically Benign Orbital Apex TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Orbital apex lesions can often be effectively and relatively safely treated by endoscopic decompression alone. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - October 19, 2009 Category: ENT & OMF Authors: Almond, M. C., Cheng, A. G., Schiedler, V., Sires, B. S., Most, S. P., Jian-Amadi, A. Tags: Oncology, Head & Neck Cancer, Ophthalmology, Ophthalmological Disorders, Ocular/ Adnexal tumors, Otolaryngology/ Head & Neck Surgery, neoplasms of Head & Neck, Surgery, Surgical Interventions, Endoscopy/ Minimally Invasive Surgery, Surgical Oncology Ori Source Type: journals

Decompression of the Orbital Apex: An Alternate Approach to Surgical Excision for Radiographically Benign Orbital Apex Tumors [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Orbital apex lesions can often be effectively and relatively safely treated by endoscopic decompression alone. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - October 19, 2009 Category: ENT & OMF Authors: Almond, M. C., Cheng, A. G., Schiedler, V., Sires, B. S., Most, S. P., Jian-Amadi, A. Tags: Oncology, Head & Neck Cancer, Ophthalmology, Ophthalmological Disorders, Ocular/ Adnexal tumors, Otolaryngology/ Head & Neck Surgery, neoplasms of Head & Neck, Surgery, Surgical Interventions, Endoscopy/ Minimally Invasive Surgery, Surgical Oncology Ori Source Type: journals

Esophageal gastrointestinal stromal tumor with pulmonary and bone metastases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present an unusual case of an esophageal GIST with pulmonary and bone lesions. We include a review of the literature. PMID: 19838991 [PubMed - as supplied by publisher] (Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology)
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - October 18, 2009 Category: Radiology Authors: Ozan E, Oztekin O, Alacacioglu A, Aykas A, Postaci H, Adibelli Z Tags: Diagn Interv Radiol Source Type: journals