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FOXL2 Mutation Associated With Adult Ovarian Granulosa Cell TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Maurie Markman comments on a study published in The New England Journal of Medicine highlighting the role of a mutation in FOXL2 in the development and/or progression of granulosa cell tumors. Medscape Genomic Medicine (Source: Medscape Ob/Gyn & Women's Health Headlines)
Source: Medscape Ob/Gyn & Women's Health Headlines - November 11, 2009 Category: OBGYN Tags: Hematology-Oncology Source Type: info

WNT signaling in ovarian follicle biology and tumorigenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The WNTS are an expansive family of glycoprotein signaling molecules known mostly for the roles they play in embryonic development. WNT signaling first caught the attention of ovarian biologists when it was reported that the inactivation of Wnt4 in mice results in partial female-to-male sex reversal and oocyte depletion. More recently, studies using loss- and gain-of-function transgenic mouse models demonstrated the requirement for Wnt4, Fzd4 and Ctnnb1, components of the WNT pathway, for normal folliculogenesis, luteogenesis and steroidogenesis, and showed that dysregulated WNT signaling can cause granulosa cell tumor...
Source: Trends in Endocrinology and Metabolism: TEM - October 27, 2009 Category: Endocrinology Authors: Boyer A, Goff AK, Boerboom D Tags: Trends Endocrinol Metab Source Type: journals

Smad1-Smad5 Ovarian Conditional Knockout Mice Develop a Disease Profile Similar to the Juvenile Form of Human Granulosa Cell Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Granulosa cell tumors (GCTs) of the ovary are rare sex cord stromal tumors. Although generally indolent, GCTs recur, and if not diagnosed and treated in early stages, survival rates are significantly shortened. Very little is known regarding GCT etiology. Because of the low incidence of cases and lack of standard diagnostics, mouse models for granulosa cell tumors are a valuable tool for studying GCTs and provide models for developing diagnostic and treatment strategies. We recently developed a novel mouse model of metastatic granulosa cell tumors by genetic deletion of the bone morphogenetic protein signaling transcri...
Source: Endocrinology - October 8, 2009 Category: Endocrinology Authors: Middlebrook BS, Eldin K, Li X, Shivasankaran S, Pangas SA Tags: Endocrinology Source Type: journals

Mono-(2-ethylhexyl) phthalate induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in human granulosa-like tumor cell line KGN.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mechanism for transcriptional suppression of CYP19 by mono-ethylhexyl phthalate (MEHP) in a human ovarian granulosa cell-line (KGN) was investigated. It is known that the CYP19 gene transcript in KGN cells predominantly includes exon PII among the 11 alternate exon I sequences. MEHP was found to significantly suppress Forskolin (FSK)-induced CYP19 gene transcription, CYP19 promoter II activity and CYP19 enzyme activity in a dose-dependent manner. Promoter assays using 5'-deleted promoter II reporter constructs suggested that the region important for responsiveness to MEHP exposure includes a putative CRE-like seque...
Source: Toxicology Letters - October 8, 2009 Category: Toxicology Authors: Ohno S, Yukinawa F, Noda M, Nakajin S Tags: Toxicol Lett Source Type: journals

Unusual and late recurrences in ovarian adult granulosa cell tumours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890588 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)
Source: Annals of the Academy of Medicine, Singapore - October 1, 2009 Category: Journals (General) Authors: Kaluarachchi A, Marasinghe JP Tags: Ann Acad Med Singapore Source Type: journals

Granulosa cell tumor arising in an ovary with mature teratoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of GCT and mature teratoma occurring synchronously in the same ovary in a perimenopausal woman. PMID: 19805973 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Trivedi P, Patel T, Jain R, Parikh B, Dave P Tags: Indian J Pathol Microbiol Source Type: journals

Ovarian cancer mouse models: A summary of current models and their limitationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epithelial ovarian cancer differs from granulosa cell tumors. Many different methods have been used to generate a viable genetic model with limited success. This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - September 27, 2009 Category: Cancer & Oncology Authors: Miranda FongSham Kakar Source Type: journals

Spontaneous pathology of the baboon endocrine systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Endocrine disease in baboons is common and shares clinical and biochemical characteristics with endocrine disease in humans. (Source: Journal of Medical Primatology)
Source: Journal of Medical Primatology - September 27, 2009 Category: Research Authors: R. Guardado-Mendoza, E.J. Dick Jr, L.M. Jimenez-Ceja, A. Davalli, A.O. Chavez, F. Folli, G.B. Hubbard Source Type: journals

Cell Type-Specific Targeted Mutations of Kras and Pten Document Proliferation Arrest in Granulosa Cells versus Oncogenic Insult to Ovarian Surface Epithelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The small G-protein KRAS is crucial for mediating gonadotropin-induced events associated with ovulation. However, constitutive expression of KrasG12D in granulosa cells disrupted normal follicle development leading to the persistence of abnormal follicle-like structures containing nonmitotic cells. To determine what factors mediate this potent effect of KrasG12D, gene profiling analyses were done. We also analyzed KrasG12D;Cyp19-Cre and KrasG12;Pgr-Cre mutant mouse models that express Cre prior to or after the initiation of granulosa cell differentiation, respectively. KrasG12D induced cell cycle arrest in granulosa cells ...
Source: Cancer Research - August 11, 2009 Category: Cancer & Oncology Authors: Fan, H.-Y., Liu, Z., Paquet, M., Wang, J., Lydon, J. P., DeMayo, F. J., Richards, J. S. Tags: Endocrinology Source Type: journals

Loss of inhibin alpha uncouples oocyte-granulosa dynamics and disrupts postnatal folliculogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Targeted disruption of the inhibin alpha gene (Inha(-/-)) in mice results in an ovarian phenotype of granulosa cell tumors that renders the animals infertile. Little is known about the reproductive defects prior to tumor development. Here, we report novel data on early follicle dynamics in Inha(-/-)mice, which demonstrate that inhibin alpha has important consequences upon follicle development. Morphological changes in both germ and somatic cells were evident in postnatal day 12 ovaries, with Inha(-/-)mice exhibiting numerous multilayered follicles that were far more advanced than those observed in age-matched controls....
Source: Developmental Biology - August 6, 2009 Category: Biology Authors: Myers M, Middlebrook BS, Matzuk MM, Pangas SA Tags: Dev Biol Source Type: journals

Ovarian Aging in Squirrel Monkeys (Saimiri sciureus).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In female squirrel monkeys (Saimiri sciureus), the reproductive period normally extends from around 2.5 years to the mid-teens. In the present study we examined the age-associated cytological changes in the ovaries of 24 squirrel monkeys ranging in age from newborn to approximately 20 years. We found a significant, age-related decline in the number of primordial follicles, with the most pronounced loss occurring between birth and 5 years. After around 8 years of age, relatively few primordial follicles were evident in the ovarian sections examined. An unusual feature of the aging squirrel monkey ovary is the emergence ...
Source: Reproduction - August 4, 2009 Category: Reproduction Medicine Authors: Walker M, Anderson D, Herndon J, Walker L Tags: Reproduction Source Type: journals

Testicular granulosa cell tumors: rare tumors need to be studied too.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19777767 [PubMed - in process] (Source: Oncology (Williston Park, N.Y.))
Source: Oncology (Williston Park, N.Y.) - July 31, 2009 Category: Cancer & Oncology Authors: Bosl GJ Tags: Oncology (Williston Park) Source Type: journals

Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of an advanced granulosa cell tumor of the testis with a confirmed partial response to an angiogenesis inhibitor after initial resistance to cytotoxic chemotherapy. PMID: 19777766 [PubMed - in process] (Source: Oncology (Williston Park, N.Y.))
Source: Oncology (Williston Park, N.Y.) - July 31, 2009 Category: Cancer & Oncology Authors: Harrison MR, Huang W, Liu G, Gee J Tags: Oncology (Williston Park) Source Type: journals

Mutant FOXL2 may be involved in pathogenesis of ovarian granulosa-cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study results show that recurrent somatic mutations in the winged helix/forkhead transcription factor gene are present in 97 percent of adult-type granulosa-cell tumors. (Source: MedWire News - Ob/Gyn)
Source: MedWire News - Ob/Gyn - July 7, 2009 Category: OBGYN Source Type: news

Juvenile Granulosa Cell Ovarian Tumor: A Case Report and Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Survival rates are >95% among patients diagnosed under 10 years of age. Tumor recurrence is rare but can occur as late as 48 months. Therefore, tumor surveillance is warranted for patients with even a Stage IA JGCT and involves monitoring serial inhibin B levels along with intermittent imaging. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - July 5, 2009 Category: OBGYN Authors: Sujatha Sivasankaran, Paul Itam, Leslie Ayensu-Coker, Judith Sanchez, Rachel A. Egler, Matthew L. Anderson, Mary L. Brandt, Jennifer E. Dietrich Tags: Case Reports Source Type: journals

Three-month-old Boy With Juvenile Granulosa Cell Tumor of Testis and Ossifying Renal Tumor of InfancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 3-month-old male infant who presented with gross hematuria and was found to have a renal mass and a testicular mass representing these two entities. This is the first case report of these two lesions presenting concomitantly. (Source: Urology)
Source: Urology - July 1, 2009 Category: Urology & Nephrology Authors: Stéfanie A. Seixas-Mikelus, Abdur Khan, Pierre E. Williot, Saul P. Greenfield Tags: Pediatric Case Reports Source Type: journals

ORIGINAL ARTICLE: Mutation of FOXL2 in Granulosa-Cell Tumors of the OvaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Somatically acquired mutations, which contribute to tumorigenesis, are usually specific to tumor tissue. Sequencing of the whole transcriptome -- the entire set of messenger RNAs -- in ovarian granulosa-cell tumors implicated a somatic mutation in FOXL2 in a large majority of the tumors that were analyzed. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - June 23, 2009 Category: Internal Medicine Authors: Shah, S. P., Kobel, M., Senz, J., Morin, R. D., Clarke, B. A., Wiegand, K. C., Leung, G., Zayed, A., Mehl, E., Kalloger, S. E., Sun, M., Giuliany, R., Yorida, E., Jones, S., Varhol, R., Swenerton, K. D., Miller, D., Clement, P. B., Crane, C., Madore, J., Tags: ORIGINAL ARTICLES Source Type: journals

Discovery of Genetic Mutation May Improve Diagnosis and Treatment of Granulosa-Cell Ovarian TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Accurate diagnosis of granulosa-cell tumors in the ovaries can be problematic, but the discovery of a new mutation might make it easier and could spur the development of new treatments. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 12, 2009 Category: Consumer Health News Tags: Hematology-Oncology Source Type: news

The Spelling Mistake In The Genetic Code That Causes A Type Of Ovarian CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eureka! Vancouver scientists from the Ovarian Cancer Research (OvCaRe) Program at BC Cancer Agency and Vancouver Coastal Health Research Institute have discovered that there appears to be a single spelling mistake in the genetic code of granulosa cell tumours, a rare and often untreatable form of ovarian cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 12, 2009 Category: Consumer Health News Tags: Ovarian Cancer Source Type: news

Found: 1 in 3 billionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of British Columbia) Vancouver scientists from the Ovarian Cancer Research (OvCaRe) Program at BC Cancer Agency and Vancouver Coastal Health Research Institute have discovered that there appears to be a single spelling mistake in the genetic code of granulosa cell tumors, a rare and often untreatable form of ovarian cancer. The discovery marks the beginning of a new era of cancer genomics. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 10, 2009 Category: Cancer & Oncology Source Type: news

No Activating Mutations of FSH Receptor in Four Children with Ovarian Juvenile Granulosa Cell Tumors and the Association of These Tumors with Central Precocious PubertyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We did not find any activating mutation in exon 10 of the FSHR in our patients, and one patient developed precocious puberty after removal of her tumor. The development of ovarian tumors in these patients may have been caused by mutations at other exons of the FSHR and G protein subunits, so the association noted between central precocious puberty and granulosa cell tumors might not be coincidental. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - May 31, 2009 Category: OBGYN Authors: Firdevs Bas, Ora Hirsch Pescovitz, Rosemary Steinmetz Tags: Original Studies Source Type: journals

Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During hormonally induced ovarian follicle growth, granulosa cell proliferation increases and returns to baseline prior to the administration of an ovulatory stimulus. Several key genes appear to follow a similar pattern, including the luteinizing hormone receptor (LHCGR), suggesting an association between cell cycle progression and gene expression. The expression of LHCGR mRNA in granulosa cells isolated from immature rats and treated in culture with FSH increased in a time-dependent manner, whereas administration of the cell cycle inhibitor mimosine completely suppressed expression. Although forskolin was able to induce ...
Source: AJP: Endocrinology and Metabolism - May 25, 2009 Category: Endocrinology Authors: Cannon, J. D., Seekallu, S. V., VandeVoort, C. A., Chaffin, C. L. Tags: ARTICLES Source Type: journals

[Epidemiology and pathological profile of childhood ovary tumours in Togo: about 32 cases.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionThe childhood ovary tumours although rare, exist in Togo dominated by Burkitt lymphoma. PMID: 19457758 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 19, 2009 Category: Cancer & Oncology Authors: Amégbor K, Darre T, Alfa AK, Napo-Koura G Tags: Bull Cancer Source Type: journals

Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Synergistic effects of dysregulation of the WNT/CTNNB1 and phosphatidylinositol 3-kinase (PI3K)/AKT pathways are thought to be important for the development and progression of many forms of cancer, including the granulosa cell tumor of the ovary. Sustained WNT/CTNNB1 signaling in Sertoli cells causes testicular degeneration and the formation of foci of poorly differentiated stromal cells in the seminiferous tubules in mice. To test if concomitant dysregulation of the WNT/CTNNB1 and PI3K/AKT pathways could synergize to cause testicular cancer, Ptentm1Hwu/tm1Hwu;Ctnnb1tm1Mmt/+;Amhr2tm3(cre)Bhr/+ mice that express a dominant,...
Source: Carcinogenesis - April 30, 2009 Category: Cancer & Oncology Authors: Boyer, A., Paquet, M., Lague, M.-N., Hermo, L., Boerboom, D. Tags: CARCINOGENESIS Source Type: journals

Secondary Amenorrhea with Low Serum Luteinizing Hormone and Follicle-stimulating Hormone Caused by an Inhibin A- and Inhibin B-producing Granulosa Cell TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: Here, we report a case of secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone levels due to an inhibin A- and inhibin B-producing granulosa cell tumor of the ovary. Case Report: A woman aged 26 ...more (Source: Taiwanese Journal of Obstetrics and Gynecology)
Source: Taiwanese Journal of Obstetrics and Gynecology - April 6, 2009 Category: OBGYN Source Type: journals

Extraovarian granulosa cell tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extraovarian granulosa cell tumor (GCT) is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. One such rare case of extraovarian GCT was encountered in a 58-year-old female who presented with a large intraabdominal lump. Computerized tomography revealed one large retroperitoneal mass measuring 15 cm x 16 cm and another mesenteric mass of 8 cm x 5 cm size. The patient had a history of hysterectomy with bilateral salpingooophorectomy 20 years ago for uterine leiomyoma. Ultrasonography-guided aspiration smears revealed cytological features suggestive of ...
Source: Indian Journal of Pathology and Microbiology - April 1, 2009 Category: Pathology Authors: Paul PC, Chakraborty J, Chakrabarti S, Chattopadhyay B Tags: Indian J Pathol Microbiol Source Type: journals

Adult granulosa cell tumor: Findings for MR imaging assessment and correlation with pathological dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Adult granulosa cell tumors were initially assessed by MR imaging in two women, age 31 and 34 years; radiologic–pathological correlation was performed thereafter. These sex-cord stromal tumors consist of a solid multinodular non-necrotic mass with fibrous septas and external wall surrounding granulosa cells islets, in which few small central and peripheral cysts are present. Some cysts are hemorrhagic, and parenchymal vasculature is poor. MR imaging is effective in our experience to assess this type of tumor prior to histological confirmation. (Source: European Journal of Radiology Extra)
Source: European Journal of Radiology Extra - April 1, 2009 Category: Radiology Authors: Alain F. Le Blanche, Renaud Bouaziz, Anabelle Werbrouck, Philippe Merviel, Henri Sevestre, Pauline Monet Source Type: journals

Compilation of classical and contemporary terminology used to describe morphological aspects of ovarian dynamics in cattle.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Veterinarians and scientists involved in applied and basic research in cattle require a lexicon of terms that is used uniformly so that diagnoses and inference of results between and among studies can be correctly interpreted and substantiated or negated and therapy and hypotheses can be formulated without unnecessary confusion and redundancy in treatments and experiments. This review provides a compilation of many of the classical and contemporary terms used in association with ovarian dynamics primarily during the estrous cycle in cattle, which can also apply to other reproductive states. While many classical terms u...
Source: Theriogenology - March 30, 2009 Category: Genetics & Stem Cells Authors: Peter AT, Levine H, Drost M, Bergfelt DR Tags: Theriogenology Source Type: journals

Isolated breast metastasis from granulosa cell tumor of the ovaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present such a case of ovarian granulosa cell tumor with metastasis to the breast, which was the presenting symptom. The patient was treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy which was followed by chemotherapy. The patient is relapse free 2 years after completion of treatment. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1025-0Authors Ashok Chauhan, Post Graduate Institute of Medical Sciences Department of Radiotherapy Rohtak IndiaPushpa Dahiya, Post Graduate Institute of Medical Sciences Department of Obstetrics and Gynaecology Rohtak IndiaHarmee...
Source: Archives of Gynecology and Obstetrics - March 21, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Review Articles: Pathogenesis and Diagnostic Significance of Nuclear Grooves in Thyroid and Other SitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nuclear grooves are longitudinal invaginations of the nuclear envelope bilayer, which constitute a characteristic feature of papillary thyroid carcinoma. Their pathogenesis is not yet clear, but there is evidence for the involvement of a signaling pathway downstream of the protooncogene RET. The presence of nuclear grooves is not specific for papillary thyroid carcinoma because it has been documented in other types of thyroid neoplasms, in nonneoplastic thyroid lesions, in ovarian neoplasms (Brenner, adult granulosa cell, and transitional cell tumors), in breast carcinomas, in cervicovaginal and endometrial smears, in papi...
Source: International Journal of Surgical Pathology - March 18, 2009 Category: Pathology Authors: Batistatou, A., Scopa, C. D. Tags: Article Source Type: journals

Association of Luteinizing Hormone Receptor Gene Expression with Cell Cycle Progression in Granulosa Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During hormonally-induced ovarian follicle growth, granulosa cell proliferation increases and returns to baseline prior to the administration of an ovulatory stimulus. Several key genes appear to follow a similar pattern, including the luteinizing hormone receptor (LHCGR), suggesting an association between cell cycle progression and gene expression. The expression of LHCGR mRNA in granulosa cells isolated from immature rats and treated in culture with FSH increased in a time-dependent manner, while administration of the cell cycle inhibitor mimosine completely suppressed expression. While forskolin was able to induce l...
Source: Am J Physiol Endocri... - March 17, 2009 Category: Endocrinology Authors: Cannon JD, Seekallu S, Vandevoort CA, Chaffin CL Tags: Am J Physiol Endocrinol Metab Source Type: journals

TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extensive apoptotic oocyte reduction occurs during fetal ovarian development. The regulatory pathways responsible for oocyte selection to programmed cell death are, however, poorly understood. The aim of this study was to investigate the potential involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its death receptors TRAIL-R1/DR4 and TRAIL-R2/DR5 and decoy receptors TRAIL-R3/DcR1 and TRAIL-R4/DcR2 in the apoptotic process characterizing human fetal and adult ovaries. For this purpose, in situ hybridization and immunohistochemistry were applied to human fetal and adult ovarian samples to ...
Source: Differentiation - March 15, 2009 Category: Research Authors: Jääskeläinen M, Kyrönlahti A, Anttonen M, Nishi Y, Yanase T, Secchiero P, Zauli G, Tapanainen JS, Heikinheimo M, Vaskivuo TE Tags: Differentiation Source Type: journals

Virilization persists in a woman with an androgen-secreting granulosa cell tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels. (Source: Fertility and Sterility)
Source: Fertility and Sterility - March 1, 2009 Category: Reproduction Medicine Authors: Satin S. Patel, Kelley S. Carrick, Bruce R. Carr Tags: Case report summaries Source Type: journals

Secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone caused by an inhibin A- and inhibin B-producing granulosa cell tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A granulosa cell tumor secretes inhibin A and B, which suppress follicle-stimulating hormone and luteinizing hormone release through a central mechanism. This leads to amenorrhea, which can be misdiagnosed as hypothalamic amenorrhea. Inhibin producing ovarian tumors must be considered in the assessment of patients with apparent hypothalamic amenorrhea. PMID: 19346197 [PubMed - in process] (Source: Taiwanese Journal of Obstetrics and Gynecology)
Source: Taiwanese Journal of Obstetrics and Gynecology - March 1, 2009 Category: OBGYN Authors: Agha-Hosseini M, Aleyaseen A, Safdarian L, Kashani L Tags: Taiwan J Obstet Gynecol Source Type: journals

Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report this rare tumor with an aim of reviewing the diagnosis and management from the reported literature. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10147-008-0805-zAuthors Harpreet Kaur, Post Graduate Institute of Medical Education and Research (PGIMER) Department of Obstetrics and Gynaecology Sector-12 Chandigarh 160012 IndiaRashmi Bagga, Post Graduate Institute of Medical Education and Research (PGIMER) Department of Obstetrics and Gynaecology Sector-12 Chandigarh 160012 IndiaSubhash Chandra Saha, Post Graduate Institute of Medical Education and Research (PGIMER) Department of Obstetrics and ...
Source: International Journal of Clinical Oncology - February 19, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

[Juvenile granulosa-cell tumor: Clinical and molecular expression.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian sex cord-stromal tumors are rare tumors that originate from the nongerminal cells of ovary. Two decades ago, the identification of juvenile granulosa-cell tumors (GCT), as a specific entity inside this group, allowed a better treatment of these tumors in children. However, little data have been reported on the natural course of the disease and reliable prognostic factors have not been yet defined. We here review the clinical and genetics aspects of granulosa tumors, based on a series of 40 children. This national collaborative study involved the French Society of Children Cancer and eight clinical departments o...
Source: Gynecologie, Obstetrique & Fertilite - December 30, 2008 Category: OBGYN Authors: Kalfa N, Philibert P, Patte C, Thibaud E, Pienkowski C, Ecochard A, Boizet-Bonhoure B, Fellous M, Sultan C Tags: Gynecol Obstet Fertil Source Type: journals

Neonatal bilateral ovarian sex cord stromal tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A child was referred for evaluation after prenatal diagnosis with macrosomia, clitoromegaly, labial hypertrophy, and a left ovarian cyst. The karyotype was 46,XX. The postnatal pelvic ultrasound was normal. High levels of anti-mullerian hormone and testosterone led to a hCG stimulation test, which was followed by isosexual precocious puberty and the appearance of a bilateral ovarian enlargement with a left tumoral mass. A left ovarian tumorectomy revealed a fibrothecoma. Six weeks later, a tumoral relapse occurred and completion of oophorectomy revealed a juvenile granulosa cell tumor (JGCT). Whereas hormonal levels decrea...
Source: Pediatric Blood and Cancer - December 4, 2008 Category: Cancer & Oncology Authors: Carmen Capito, Isabelle Flechtner, Elisabeth Thibaud, Sophie Emond, Nicolas Kalfa, Francis Jaubert, Sabine Sarnacki Source Type: journals

Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: KGN cells cultured in vitro acquire an aggressive phenotype, which was confirmed by the analysis of cellular activities and the expression of biomarkers. Interestingly, KGN cells injected s.c. are metastatic with nodule formation occurring mostly in the bowel. Thus, this cell line is a good model for analysing GCT progression and the mechanism of metastasis in vivo. (Source: BMC Cancer)
Source: BMC Cancer - November 4, 2008 Category: Cancer & Oncology Authors: Misa Imai, Miho Muraki, Kiyoshi Takamatsu, Hidekazu Saito, Motoharu Seiki and Yuji Takahashi Source Type: journals

Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mechanisms of granulosa cell tumor (GCT) development may involve the dysregulation of signaling pathways downstream of follicle-stimulating hormone, including the phosphoinosite-3 kinase (PI3K)/AKT pathway. To test this hypothesis, a genetically engineered mouse model was created to derepress the PI3K/AKT pathway in granulosa cells by conditional targeting of the PI3K antagonist gene Pten (Ptenflox/flox;Amhr2cre/+). The majority of Ptenflox/flox;Amhr2cre/+ mice featured no ovarian anomalies, but occasionally (~7%) developed aggressive, anaplastic GCT with pulmonary metastases. The expression of the PI3K/AKT downstream ...
Source: Carcinogenesis - October 31, 2008 Category: Cancer & Oncology Authors: Lague, M.-N., Paquet, M., Fan, H.-Y., Kaartinen, M. J., Chu, S., Jamin, S. P., Behringer, R. R., Fuller, P. J., Mitchell, A., Dore, M., Huneault, L. M., Richards, J. S., Boerboom, D. Tags: CANCER BIOLOGY Source Type: journals

Investigating differentiation mechanisms of the constituent cells of sex cord-stromal tumours of the ovaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract SOX-9, an essential factor for male sexual development, can be induced by prostaglandin D2 in a Sry-independent mechanism. Recent data suggest that the hedgehog pathway is involved in the differentiation of normal Sertoli and Leydig cells. The purpose of our study was to investigate the mechanisms involved in the differentiation of ovarian sex cord-stromal tumour (SCST) cells. Two Sertoli–Leydig cell tumours and two granulosa cell tumours with a minor Sertoli element were studied using immunohistochemistry on paraffin-embedded tissue sections. Sertoli cells expressed anti-Mullerian hormone (AMH), ...
Source: Virchows Archiv - October 1, 2008 Category: Pathology Tags: Virchows Archiv Source Type: journals

Granulosa Cell Tumor of the Ovary: Tumor ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Granulosa cell tumors of the ovary are rare neoplasms that originate from sex-cord stromal cells. The long natural history of granulosa cell tumors and their tendency to recur years after the initial diagnosis are the most prominent of their characteristics. The secretion of estradiol is the reason for signs at presentation such as vaginal bleeding and precocious puberty. Abdominal pain and hemoperitoneum, which occasionally can occur, are attributable to tumor rupture. The most common finding in pelvic examination is a tumor mass, which is subsequently confirmed with imaging techniques. Surgery is the mainstay of initial ...
Source: Integrative Cancer Therapies - September 23, 2008 Category: Cancer & Oncology Authors: Koukourakis, G. V., Kouloulias, V. E., Koukourakis, M. J., Zacharias, G. A., Papadimitriou, C., Mystakidou, K., Pistevou-Gompaki, K., Kouvaris, J., Gouliamos, A. Tags: Review Articles Source Type: journals

Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): A comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In previous studies, we have demonstrated a number of cytogenetic alterations in granulosa cell tumors (GCTs), especially on chromosomes X, 12, 14, and 22. However, little is known about specific loci on 14q, which could play an important role in tumor pathology. Therefore, we assessed four important genes in 30 GCTs using fluorescence-in situ-hybridization (FISH). Comparative genomic hybridization (CGH) was performed on paraffin-embedded material. Then, we applied FISH with gene-specific DNA probes for AKT1 (14q32.32), FOS (14q24.3), BCL2L2 (14q11.2-q12), and TGFbeta3 (14q24), and tried to find a correlation between C...
Source: Pathology, Research and Practice - September 5, 2008 Category: Pathology Authors: Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J Tags: Pathol Res Pract Source Type: journals

The use of bevacizumab in refractory ovarian granulosa-cell carcinoma with symptomatic relief of ascites: A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Bevacizumab may have a role in the management of malignant ascites in the patient with refractory granulosa-cell carcinoma of the ovary which should be confirmed in a larger series of well selected patients. PMID: 18710781 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 16, 2008 Category: Cancer & Oncology Authors: Kesterson JP, Mhawech-Fauceglia P, Lele S Tags: Gynecol Oncol Source Type: journals

Regulation of bovine tumor necrosis factor alpha induced protein 6 in ovarian follicles during the ovulatory process and promoter activation in granulosa cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To study the regulation of bovine tumor necrosis factor alpha induced protein 6 (TNFAIP6) prior to ovulation, preovulatory follicles obtained after the treatment with human chorionic gonadotropin (hCG) were used. RT-PCR analyses showed that levels of TNFAIP6 mRNA were low before hCG, but significant increased after hCG treatment in follicles. Further analyses and immunohistochemistry indicated that this increase in transcript and protein levels occurred in theca and granulosa cells. To investigate molecular mechanisms involved in TNFAIP6 transactivation, the activity of bovine TNFAIP6 promoter was studied in granulosa ...
Source: Endocrinology - August 7, 2008 Category: Endocrinology Authors: Sayasith K, Bouchard N, Doré M, Sirois J Tags: Endocrinology Source Type: journals

Management of granulosa cell tumour of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 560DOI: 10.1097/CCO.0b013e328306316fAuthors: Jamieson, Stacey; Fuller, Peter J (Source: Current Opinion in Oncology)
Source: Current Opinion in Oncology - August 6, 2008 Category: Cancer & Oncology Tags: Abstract HTML PDF (104 K) Source Type: journals

[Editorials] Prognostic factors in ovarian adult granulosa cell tumourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - July 28, 2008 Category: Pathology Authors: Miller, K., McCluggage, W G. Tags: Editorials Source Type: journals

[Original articles] Prognostic value of mitotic counts and Ki-67 immunoreactivity in adult-type granulosa cell tumour of the ovaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that proliferation assessment is of limited value in the pathological assessment of GCT. Future studies should carefully specify the methods of assessing cell proliferation to ensure a reliable comparison of results. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - July 28, 2008 Category: Pathology Authors: Leuverink, E M, Brennan, B A, Crook, M L, Doherty, D A, Hammond, I G, Ruba, S, Stewart, C J R Tags: Original articles Source Type: journals

Expression of CD56 isoforms in primary and relapsed adult granulosa cell tumors of the ovaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Expression of CD56 is an additional sensitive and helpful immunohistochemical tool for histopathologists diagnosing a GCT. It does not seem possible to provide a validly individual risk assessement. However, the different expression of CD56 isoforms might indicate important changes in the course to a more malignant behaviour. (Source: BioMed Central)
Source: BioMed Central - July 9, 2008 Category: Journals (General) Authors: Hans-Ullrich Volker, Sabine Engert, Andreas Cramer, Melanie Schmidt, Ulrike Kammerer, Hans-Konrad Muller-Hermelink and Stefan Gattenlohner Source Type: journals

Expression of anti-Müllerian hormone (AMH) in equine granulosa-cell tumors and in normal equine ovaries.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, AMH was strongly expressed by granulosa cells in equine GCT and in normal antral follicles. Therefore, anti-Müllerian hormone may be a useful biomarker for detection of GCT in the horse. PMID: 18599114 [PubMed - as supplied by publisher] (Source: Theriogenology)
Source: Theriogenology - July 2, 2008 Category: Stem Cells Authors: Ball BA, Conley AJ, Maclaughlin DT, Grundy SA, Sabeur K, Liu IK Tags: Theriogenology Source Type: journals

Role of cell death ligand and receptor system on regulation of follicular atresia in pig ovaries.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several hundred thousand primordial follicles are present in the mammalian ovary, however, only a limited number develop to the pre-ovulatory stage, and then finally ovulate. The others, more than 99%, will be eliminated through a degenerative process called 'atresia'. The endocrinological regulatory mechanisms involved in follicular development and atresia have been characterized to a large extent, but the precise temporal and molecular mechanisms involved in the regulation of these events have remained unknown. From many recent studies, it is suggested that the apoptosis in ovarian granulosa cells plays a crucial rol...
Source: Reproduction in Domestic Animals - July 1, 2008 Category: Reproduction Medicine Authors: Manabe N, Matsuda-Minehata F, Goto Y, Maeda A, Cheng Y, Nakagawa S, Inoue N, Wongpanit K, Jin H, Gonda H, Li J Tags: Reprod Domest Anim Source Type: journals