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This page shows you the latest news and research items in this category.

Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumours: An overview
Abstract Testicular germ cell tumors (TGCTs), the most common malignancy in males between 15 and 34 years of age and the most frequent cause of death from solid tumors in this age group. TGCTs can be subdivided into seminoma and non‐seminoma germ cell tumors (NSGCTs), including embryonal cell carcinoma, choriocarcinoma, yolk sac tumor, and teratoma. Seminomas and NSGCTs do not only present distinctive clinical features, but they also show significant differences as far as therapy and prognosis are concerned. Seminomas are highly sensitive to both radiation and chemotherapy, with a good prognosis, non‐seminomas are sens...
Source: Journal of Cellular Physiology - January 28, 2013 Category: Cytology Authors: Paolo Chieffi, Sergio Chieffi Tags: Mini‐Review Source Type: research

Primary Yolk Sac Tumor of the Omentum: A Case Report and Literature Review
Case Rep Oncol 2012;5:671–675 (DOI:10.1159/000337281) (Source: Karger Publishers)
Source: Karger Publishers - December 19, 2012 Category: Cancer & Oncology Source Type: research

Meiosis error and subsequent genetic and epigenetic alterations invoke the malignant transformation of germ cell tumor
Abstract Germ cell tumors (GCTs) are thought to arise from primordial germ cells (PGCs) that undergo epigenetic reprogramming. To explore the mechanisms of GCT formation, we analyzed single‐nucleotide polymorphism array comparative genomic hybridization patterns and the methylation status of 15 tumor suppressor genes (TSGs) and differentially methylated regions (DMRs) of two imprinted genes, H19 and SNRPN, in 28 children with GCTs. Three GCTs with 25–26 segmental uniparental disomies (UPDs), heterozygous centromeric regions, and a highly methylated SNRPN DMR may have occurred through meiosis I error. Three other GCTs w...
Source: Genes, Chromosomes and Cancer - December 8, 2012 Category: Cancer & Oncology Authors: Mizuho Ichikawa, Yasuhito Arai, Masayuki Haruta, Shinsuke Furukawa, Tadashi Ariga, Tadashi Kajii, Yasuhiko Kaneko Tags: Research Article Source Type: research

Mixed germ cells tumour primarily located in the thyroid - a case report.
In conclusion, extragonadal germ cells tumours are rare, but should be considered while co-existing with elevated markers such as: AFP, beta-HCG and lack of abnormalities in the gonads. (Endokrynol Pol 2012; 63 (5): 388-390). PMID: 23115073 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - November 13, 2012 Category: Endocrinology Authors: Wierzbicka-Chmiel J, Chrószcz M, Słomian G, Kajdaniuk D, Zajęcki W, Borgiel-Marek H, Marek B Tags: Endokrynol Pol Source Type: research

Secondary Cytoreductive Surgery for Primary Yolk Sac Tumor Arising from the Omentum
Journal of Gynecologic Surgery , Vol. 0, No. 0. (Source: Journal of Gynecologic Surgery)
Source: Journal of Gynecologic Surgery - November 5, 2012 Category: OBGYN Tags: article Source Type: research

A case report of non-islet cell tumour hypoglycaemia associated with ovarian germ-cell tumour.
Conclusions:This case illustrates the need for awareness among general physicians of rare tumour manifestations and the need for multidisciplinary input for the optimal management of these patients. PMID: 23128903 [PubMed - as supplied by publisher] (Source: Palliative Medicine)
Source: Palliative Medicine - November 5, 2012 Category: Palliative Care Authors: Powter L, Phillips S, Husbands E Tags: Palliat Med Source Type: research

Spontaneous Nonmetastatic Choriocarcinoma, Yolk Sac Carcinoma, Embryonal Carcinoma, and Teratoma in the Testes of a Swiss Albino Mouse.
Abstract A 12-week-old Swiss Albino mouse was presented with unilateral (left) testicular enlargement of approximately 1.5 cm in diameter and the right testicle mildly reduced in size and weight. Histopathology evaluation revealed three distinct neoplasms in the left testicle: choriocarcinoma, yolk sac carcinoma, and embryonal carcinoma. Teratoma was diagnosed in the right testicle. The histomorphological and immunohistochemical characteristics of the tumor are presented here. To the best of the authors' knowledge, this is the first report of spontaneous nonmetastasizing choriocarcinoma, yolk sac carcinoma, embryon...
Source: Toxicologic Pathology - October 26, 2012 Category: Pathology Authors: Jamadagni SB, Jamadagni PS, Lacy SH, Williams B, Upadhyay SN, Gaidhani SN, Hazra J Tags: Toxicol Pathol Source Type: research

A Practical Approach to Immunohistochemical Diagnosis of Ovarian Germ Cell Tumors and Sex Cord‐Stromal Tumors
Abstract Immunohistochemistry can be useful in the diagnosis of ovarian germ cell tumors and sex cord‐stromal tumors. A wide variety of markers are available, including many that are novel. The aim of this review is to provide a practical approach to selection and interpretation of these markers, emphasizing an understanding of their sensitivity and specificity in the particular differential diagnosis in question. The main markers discussed include those for malignant germ cell differentiation (SALL4, PLAP), dysgerminoma (OCT4, CD117, D2‐40), yolk sac tumor (AFP, Glypican‐3), embryonal carcinoma (OCT4, CD30, SOX2), s...
Source: Histopathology - October 25, 2012 Category: Pathology Authors: Joseph T Rabban, Charles J Zaloudek Tags: Review Source Type: research

N-cadherin expression in malignant germ cell tumours of the testis
Conclusions: N-cadherin expression can be used to differentiate embryonal carcinomas and chorionic carcinomas from other histological subtypes of TGCT. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - October 15, 2012 Category: Pathology Authors: Felix BremmerBernhard HemmerleinArne StraussPeter BurfeindPaul ThelenHeinz-Joachim RadzunCarl Behnes Source Type: research

Teratomas: A Multimodality Review
Germ cell tumors (GCTs) may occur in both children and adults and include a broad array of histologic subtypes, such as teratoma, seminoma (known as dysgerminoma in the ovary and germinoma in the pineal gland), choriocarcinoma, yolk sac tumor, embryonal cell carcinoma, and mixed GCT. In adults, GCTs occur most commonly in the gonads. In children, sacrococcygeal tumors predominate. Teratomas are a common form of GCT. They are defined histologically as containing tissues derived from all 3 germ cell layers: ectoderm, mesoderm (most teratomas contain fat, an imaging hallmark, which is a mesodermal derivative), and endoderm. T...
Source: Current Problems in Diagnostic Radiology - September 24, 2012 Category: Radiology Authors: Christine M. Peterson, Celine Buckley, Susan Holley, Christine O. Menias Tags: Original Articles Source Type: research

Primary yolk sac tumor in diaphragm
Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s00383-012-3173-8Authors Yao Zhang, Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004 People’s Republic of ChinaShu-Cheng Zhang, Department of Pediatric Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, People’s Republic of ChinaWei-Dong Ren, Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004 People’s Republic of ChinaWei-Lin Wang, Department of Pediatric Surgery, Shengjing Hospital of China Medical Universi...
Source: Pediatric Surgery International - September 14, 2012 Category: Surgery Tags: Pediatric Surgery International Source Type: research

Primary yolk sac tumor of seminal vesicle: a case report and literature review
We report a case of yolk sac tumor in the seminal vesicle.CaseA 38-year-old Asian male presented with gross hematuria and hemospermia. Transrectal ultrasound scan showed a solid mass in the left seminal vesicle and the scrotal sonography showed no abnormalities. Bilateral seminal vesicles were resected, and histopathological examination showed a typical pattern of yolk sac tumor (YST). The patient responded poorly to comprehensive treatment of radiotherapy, chemotherapy and surgeries, developed systemic multiple metastases, and died of cachexia one and half years after diagnosis. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - September 14, 2012 Category: Cancer & Oncology Authors: Xu-Dong YaoYa-Ping HongDing-Wei YeChao-Fu Wang Source Type: research

EPCAM–A novel molecular target for the treatment of pediatric and adult germ cell tumors
Abstract Germ cell tumors (GCTs) are thought to develop from totipotent primordial germ cells. Although the epithelial cell adhesion molecule (EPCAM) is expressed on embryonic stem cells as well as different tumor cells, it has not yet been extensively studied in GCTs. We analyzed EPCAM expression by quantitative RT‐PCR in 48 fresh‐frozen GCT specimens of different histology (10 mature teratoma, MT; 6 immature teratoma, IT; 7 dysgerminoma; 6 mixed malignant GCTs; 19 yolk sac tumor, YST) and in the GCT cell lines NCCIT, TE76.T, JAR and 2102Ep, and correlated its expression with AFP and hCG protein levels, histologic dif...
Source: Genes, Chromosomes and Cancer - September 14, 2012 Category: Cancer & Oncology Authors: Stefan Schönberger, Vera Okpanyi, Gabriele Calaminus, Sebastian Heikaus, Ivo Leuschner, James C. Nicholson, Nikolas H. Stoecklein, Dominik T. Schneider, Arndt Borkhardt Tags: Research Article Source Type: research

Molecular Biomarkers as Potential Targets for Therapeutic Strategies in Human Testicular Germ Cell Tumours: An Overview.
Abstract Testicular germ cell tumors (TGCTs), the most common malignancy in males between 15 and 34 years of age, represent a major cause of death attributable to cancer in this age group. TGCTs can be subdivided into seminoma and non-seminoma germ cell tumors (NSGCTs), including embryonal cell carcinoma, choriocarcinoma, yolk sac tumor, and teratoma. Seminomas and NSGCTs do not only present distinctive clinical features, but they also show significant differences as far as therapy and prognosis are concerned. Seminomas are highly sensitive to both radiation and chemotherapy, with a good prognosis, non-seminomas ar...
Source: Current Molecular Medicine - August 31, 2012 Category: Molecular Biology Authors: Chieffi P, Chieffi S Tags: Curr Mol Med Source Type: research

High grade serous carcinoma of the ovary with a yolk sac tumour component in a postmenopausal woman: report of an extremely rare phenomenon
High grade serous carcinoma is the most common ovarian epithelial malignancy.1 Ovarian yolk sac tumours (YST) are much more uncommon and are morphologically heterogeneous, primitive teratoid neoplasms differentiating into multiple endodermal structures.2 They almost always occur before age 30 and are extremely rare in perimenopausal and postmenopausal women. Rare examples have been reported in elderly patients, sometimes associated with an ovarian surface epithelial-stromal tumour, most commonly endometrioid adenocarcinoma but occasionally carcinosarcoma, clear cell carcinoma or a mucinous neoplasm; rarely the epithelial c...
Source: Journal of Clinical Pathology - August 28, 2012 Category: Pathology Authors: Varia, M., McCluggage, W. G., Oommen, R. Tags: PostScript Source Type: research

Yolk sac tumor of the vulva: a case report with recurrence after long-term follow-up
This report presents the 13th known case of vulvar YST, with recurrence occurring after the longest known follow-up period so far reported in the literature. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s00383-012-3153-zAuthors Kyoko Mochizuki, Division of Pediatric Surgery, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501 JapanMasayuki Obatake, Division of Pediatric Surgery, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501 JapanYasuaki Taura, Division of ...
Source: Pediatric Surgery International - August 7, 2012 Category: Surgery Tags: Pediatric Surgery International Source Type: research

Prepubertal testicular and paratesticular tumors in China: a single-center experience over a 10-year period
Conclusions: Most of the prepubertal testicular lesions were benign, and the most common histologic subtype was teratoma. Our experience with testis-sparing procedures supports the current trends that less invasive treatment should be performed for benign lesions. This study confirms the excellent cure rates obtained in children with prepubertal testicular tumors. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - August 1, 2012 Category: Surgery Authors: Xiaohao Wang, Shan Xu, Daxing Tang, Minju Li, Dehua Wu, Yong Huang Tags: Original Articles Source Type: research

Distinct expression pattern of claudin‐6, a primitive phenotypic tight junction molecule, in germ cell tumours and visceral carcinomas
Conclusions: This study demonstrated that claudin‐6 is a novel diagnostic marker for primitive germ cell tumours and is also expressed frequently in some cancers with a primitive phenotype. (Source: Histopathology)
Source: Histopathology - July 17, 2012 Category: Pathology Authors: Tetsuo Ushiku, Aya Shinozaki‐Ushiku, Daichi Maeda, Shigeki Morita, Masashi Fukayama Source Type: research

[Testicular and paratesticular tumors during childhood and adolescence.]
CONCLUSIONS: Testicular and paratesticular tumors in prepubertal children show epidemiological, histological, therapeutical and evolutional characteristics well differentiated from postpubertal or adult subjects. PMID: 22727932 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - June 22, 2012 Category: Pediatrics Authors: Caballero Mora FJ, Muñoz Calvo MT, García Ros M, Rodríguez de Alarcón J, Fernández Pérez ML, Casco F, Argente J Tags: An Pediatr (Barc) Source Type: research

Fetal and neonatal germ cell tumors
Summary: Germ cell tumors (GCTs) arise from the ‘germline’ – the primordial germ cells which are destined to become either the egg or the sperm. GCTs can be challenging to understand because their intrinsic pluripotency results in a wide spectrum of histologies and biologic behaviors. However, the histology of GCTs in the fetus and neonate is more restricted and the clinical spectrum more narrow than when these tumors occur later in life. GCTs in the fetus and neonate are predominately mature and immature teratomas, usually curable with surgery alone. And, given the efficacy of cisplatin-based regimens in GCTs, cure ...
Source: Seminars in Fetal and Neonatal Medicine - May 30, 2012 Category: Perinatology & Neonatology Authors: A. Lindsay Frazier, Christopher Weldon, James Amatruda Tags: Editorial Source Type: research

Rare solid tumors of the pancreas as differential diagnosis of pancreatic adenocarcinoma.
CONCLUSION: If rare benign and malignant pancreatic tumors, intrapancreatic metastasis, as well as pancreatic malformations or other abnormalities, present themselves as solid masses of the pancreas, they constitute an important differential diagnosis to primary pancreatic neoplasia, e.g. pancreatic ductal adenocarcinoma. Clinical imaging techniques cannot always rule out malignancy, thus operative exploration often remains the treatment of choice to provide the correct diagnosis and initiate adequate surgical therapy. PMID: 22572130 [PubMed - in process] (Source: JOP)
Source: JOP - May 11, 2012 Category: Gastroenterology Authors: Kersting S, Janot MS, Munding J, Suelberg D, Tannapfel A, Chromik AM, Uhl W, Bergmann U Tags: JOP Source Type: research

Distinct expression pattern of claudin‐6, a primitive phenotypic tight junction molecule, in germ cell tumors and visceral carcinomas
Conclusions: This study demonstrated that claudin‐6 is a novel diagnostic marker for primitive germ cell tumors and is also frequently expressed in some cancers with a primitive phenotype.© 2012 Blackwell Publishing Ltd (Source: Histopathology)
Source: Histopathology - April 26, 2012 Category: Pathology Authors: Tetsuo Ushiku, Aya Shinozaki‐Ushiku, Daichi Maeda, Shigeki Morita, Masashi Fukayama Source Type: research

α-Fetoprotein–producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression
In conclusion, hepatoid gastric carcinoma and combined hepatocellular and cholangiocarcinoma shared morphologies, whereas the distinction of hepatoid gastric carcinoma from combined hepatocellular and cholangiocarcinoma is possible by immunostaining for SALL4. These 2 tumors seem to differ in their histogenesis with respect to SALL4 expression.1. (Source: Human Pathology)
Source: Human Pathology - April 19, 2012 Category: Pathology Authors: Hiroko Ikeda, Yasunori Sato, Norihide Yoneda, Kenichi Harada, Motoko Sasaki, Seiko Kitamura, Yoshiko Sudo, Akishi Ooi, Yasuni Nakanuma Tags: Original Contributions Source Type: research

Human umbilical cord wharton's jelly mesenchymal stem cells do not transform to tumor‐associated fibroblasts in the presence of breast and ovarian cancer cells unlike bone marrow mesenchymal stem cells
AbstractHuman bone marrow mesenchymal stem cells (hBMMSCs) were shown to transform into tumor‐associated fibroblasts (TAFs) when in the vicinity of breast cancer tumors and played an important role in tumor enhancement and metastasis. In early human development MSCs migrating from the yolk sac and aorta‐gonad‐mesonephros (AGM) via the umbilical cord to the placenta and back to the fetal bone marrow were shown to get trapped in the gelatinous Wharton's jelly of the umbilical cord. The common origin of the Wharton's jelly MSCs and the finally homed hBMMSCs prompted us to evaluate whether hWJSCs are also involved in TAF...
Source: Journal of Cellular Biochemistry - April 10, 2012 Category: Biochemistry Authors: Arjunan Subramanian, Gan Shu‐Uin, Ngo Kae‐Siang, Kalamegam Gauthaman, Arijit Biswas, Mahesh Choolani, Ariff Bongso, Fong Chui‐Yee Tags: Article Source Type: research

Reply
It has been the aim of this paper to try to investigate the distribution and management of pediatric testicular germ cell tumor (TGCT) in South China. As the same as some institutions reported, yolk sac tumor was the most common tumor, though the percentage was a little different. Testicular embryonal carcinoma in children was also rare in China. (Source: Urology)
Source: Urology - April 1, 2012 Category: Urology & Nephrology Authors: Zi-Ke Qin, Yun-Lin Ye Tags: Pediatric Urology Source Type: research

Editorial Comment
The authors are to be congratulated for their review of children with primary testicular tumors who were referred to their medical centers in south China. The preponderance of yolk sac tumors seen during the review period (51%) is somewhat less than reported in the AAP Section of Urology Prepubertal Testis Tumor Registry (PTTR) figures published in 2002 (62%) but is very similar to the prevalence of yolk sac tumors in pediatric patients from a review performed in Korea in 2004 (47.8%). (Source: Urology)
Source: Urology - April 1, 2012 Category: Urology & Nephrology Authors: Irene McAleer Tags: Pediatric Urology Source Type: research

Therapeutic Potential of SOX2 Inhibition for Embryonal Carcinoma
Conclusions: This study shows the therapeutic potential of SOX2 silencing for embryonal carcinoma. However, further improvements are needed in SOX2-siRNA delivery to the tumor. (Source: The Journal of Urology)
Source: The Journal of Urology - March 19, 2012 Category: Urology & Nephrology Authors: Hiroshi Ushida, Tokuhiro Chano, Kahori Minami, Hiroko Kita, Takahiro Kawakami, Hidetoshi Okabe, Yusaku Okada, Keisei Okamoto Tags: Investigative Urology Source Type: research

Malignant Germ Cell-Like Tumors, Expressing Ki-1 Antigen (CD30), Are Revealed during in Vivo Differentiation of Partially Reprogrammed Human-Induced Pluripotent Stem Cells.
Abstract Because many of the genes used to produce induced pluripotent stem cells (iPSCs) from somatic cells are either outright established oncogenes, such as c-myc and Klf4, or potentially related to tumorigenesis in various cancers, both the safety and the risks of tumorigenesis linked to iPSC generation require evaluation. In this work, we generated, by lentivirus-mediated gene transfer of Oct4, Sox2, Nanog, and Lin28, two types of iPSCs from human mesenchymal stem cells and human amniotic fluid-derived cells: fully reprogrammed iPSCs with silencing of the four transgenes and partially reprogrammed iPSCs that s...
Source: The American Journal of Pathology - March 13, 2012 Category: Pathology Authors: Griscelli F, Féraud O, Oudrhiri N, Gobbo E, Casal I, Chomel JC, Biéche I, Duvillard P, Opolon P, Turhan AG, Bennaceur-Griscelli A Tags: Am J Pathol Source Type: research

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor
The testicular yolk sac tumor (TYST) is the most common neoplasm originated from germ cells differentiated abnormally, a major part of pediatric malignant testicular tumors. The present study aimed at developing and validating the in vitro and vivo models of TYST and evaluating the sensitivity of TYST to treatments, by cloning human TYST cells and investigating the histology, ultra-structure, growth kinetics and expression of specific proteins of cloned cells. We found biological characteristics of cloned TYST cells were similar to the yolk sac tumor and differentiated from the columnar to glandular-like or goblet cells-li...
Source: Journal of Translational Medicine - March 13, 2012 Category: Research Authors: Junfeng ZhaoCongde ChenHaochuan ZhangJinhui ShenHua ZhangXiaokun LinLe QinXiaozhou BaoJie LinWenqiang LuXiangdong WangXiaoming Chen Source Type: research

Leptomeningeal carcinomatosis in aggressive germ non-seminoma testicular tumor: A case report and review of literature
Testicular cancer (TC) is the most common tumor of young males and its incidence has approximately doubled worldwide over the past 40years, without a comprehensible etiology for the observed increase . Both environmental and genetic factors are likely to be involved . Germ cell tumors (GCTs) are malignancies derived from primitive stem-cells and are divided into two categories based on histology: tumors included pure seminoma and tumors with some component of non-seminoma (NS), such as teratoma, embryonal carcinoma, choriocarcinoma and yolk sac tumor. GCTs are curative diseases, with cure rates of over 80% . However, 28% o...
Source: Clinical Neurology and Neurosurgery - March 9, 2012 Category: Neurosurgery Authors: Emanuela Onesti, Alessandra Fabi, Marielisa Mingoia, Antonella Savarese, Vincenzo Anelli, Tatiana Koudriavtseva Tags: Case Reports Source Type: research

Oophorectomy in children. Who and why: 13‐year experience in a single centre
Conclusion: Although ovarian pathology is uncommon in children, a girl presenting with acute lower abdominal pain or progressive abdominal distension should raise the suspicion and prompt immediate investigation to rule out ovarian torsion or ovarian neoplasms. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - March 7, 2012 Category: Pediatrics Authors: Yuen Shan WongYuk Him TamKristine Kit Yi PangJennifer Wai Cheung MouKin Wai ChanKim Hung Lee Source Type: research

Advanced extragonadal yolk sac tumor serially followed up with 18F‐fluorodexyglucose‐positoron emission tomography and computerized tomography and serum alpha‐fetoprotein
We report a case of a primary YST disseminated throughout the abdomen and associated with a high serum alpha‐fetoprotein (AFP) elevation (441 611 ng/ml). Optimal cytoreduction was not achieved in order to preserve the patient's fertility and avoid adjacent organ injury. Residual tumor responded to adjuvant chemotherapy with a sharp decline in AFP levels, and confirmed remission was documented by serial 18F‐fluorodexyglucose‐positoron emission tomography and computerized tomography (FDG‐PET/CT). In cases of advanced YST with unresectable residual disease, AFP levels combined with FDG‐PET/CT scans may be a help...
Source: Journal of Obstetrics and Gynaecology Research - February 22, 2012 Category: OBGYN Authors: Tsukasa BabaSaori SuShigeaki UmeokaKaoru AbikoYuji NakamotoMasaki MandaiNoriomi MatsumuraIkuo Konishi Source Type: research

Bone metastases in germ cell tumor patients
Conclusions Bone metastases were associated with a primary mediastinal nonseminoma, yolk sac histology, and liver metastases at first diagnosis. In this cohort of patients receiving HD-CTX as first-line treatment, 63% achieved long-term progression-free survival. Skeletal relapses were rare, but showed dismal outcome. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-012-1169-3Authors Karin Oechsle, Department of Oncology/Hematology/Bone marrow transplantation/Pneumology, University Medical Center Eppendorf, Martinistr. 52, 20246 Hamburg, GermanyCarsten Bokemeyer, Depart...
Source: Journal of Cancer Research and Clinical Oncology - February 21, 2012 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: research

[Management of extragonadic Yolk sac tumor with hepatic metastasis.]
PMID: 22326666 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - February 9, 2012 Category: Journals (General) Authors: Bouassida M, Sassi S, Laajili A, Mighri M, Touinsi H, Sassi S Tags: Presse Med Source Type: research

Clinical Analysis of Management of Pediatric Testicular Germ Cell Tumors
Conclusion: Yolk sac tumor is the most common type of pediatric testicular tumor. For stage I yolk sac tumor, radical inguinal orchiectomy is effective, salvage chemotherapy is promising, and RPLND may not be necessary. (Source: Urology)
Source: Urology - February 3, 2012 Category: Urology & Nephrology Authors: Yun-Lin Ye, Xiang-Zhou Sun, Fu-Fu Zheng, Jun Bian, Yan-Ping Huang, Xue-Qi Zhang, Zhi-Xun Li, Ying Nie, Zi-Ke Qin, Yu-Ping Dai Tags: Pediatric Urology Source Type: research

Human umbilical cord Wharton's jelly mesenchymal stem cells do not transform to tumor‐associated fibroblasts in the presence of breast and ovarian cancer cells unlike bone marrow mesenchymal stem cells
AbstractHuman bone marrow mesenchymal stem cells (hBMMSCs) were shown to transform into tumor‐associated fibroblasts (TAFs) when in the vicinity of breast cancer tumors and played an important role in tumor enhancement and metastasis. In early human development MSCs migrating from the yolk sac and aorta‐gonad‐mesonephros (AGM) via the umbilical cord to the placenta and back to the fetal bone marrow were shown to get trapped in the gelatinous Wharton's jelly of the umbilical cord. The common origin of the Wharton's jelly MSCs and the finally homed hBMMSCs prompted us to evaluate whether hWJSCs are also involved in TAF...
Source: Journal of Cellular Biochemistry - January 10, 2012 Category: Biochemistry Authors: Arjunan SubramanianGan Shu‐UinNgo Kae‐SiangKalamegam GauthamanArijit BiswasMahesh ChoolaniAriff BongsoFong Chui‐Yee Tags: Article Source Type: research

A case of yolk sac tumor of the vagina in an infant
We report a case of a vaginal yolk sac tumor in a 5-month-old female infant who presented with short history of bleeding per vagina. Magnetic resonance imaging showed a mass occupying most of the vagina that had lobulated outlines and heterogeneous echo texture. The serum alpha-fetoprotein was elevated, and a biopsy revealed a vaginal yolk sac tumor. The patient was given six cycles of chemotherapy and continues to be disease-free on follow up. To preserve sexual and reproductive function, we encourage consideration of chemotherapy as a sole modality to treat this rare tumor. Content Type Journal ArticleCategory G...
Source: Archives of Gynecology and Obstetrics - January 7, 2012 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Oral extragonadal yolk sac tumor in a patient with Aicardi syndrome: putative origin and differential diagnosis
We report, for the first time, a primary oral presentation of a germ cell yolk sac tumor in a 4-year-old girl with Aicardi syndrome. The diagnosis, differential diagnosis, and histogenesis are discussed. (Source: Human Pathology)
Source: Human Pathology - January 6, 2012 Category: Pathology Authors: Rhonda Burch-Smith, Nelson G. Ordonez, Lawrence E. Ginsberg, Joann L. Ater, Adel K. El Naggar Tags: Case Studies Source Type: research

Expression of carbonic anhydrase IX in genitourinary and adrenal tumours
Conclusions: Carbonic anhydrase IX is a sensitive marker for clear cell RCC in core biopsies. However, other genitourinary or adrenal tumours that can have a clear cell appearance including urothelial, squamous cell, clear cell adeno and adrenal cortical carcinoma and Sertoli cell tumour express CAIX. Knowledge of expression overlap between these entities may prevent incorrect interpretation of immunohistochemical results, particularly if limited tissue is available. (Source: Histopathology)
Source: Histopathology - December 1, 2011 Category: Pathology Authors: Daniel P DonatoMatthew T JohnsonXiming J YangDebra L Zynger Source Type: research

Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy
Abstract Ovarian yolk sac tumor (YST) is a highly aggressive malignancy arising in young women. Chemotherapy has dramatically improved the prognosis, and bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy appears to be the most effective combination regimen. A 23-year-old woman was admitted to our hospital with worsening abdominal distention and a lower abdominal mass. She was diagnosed with a stage IIIc pure YST of the right ovary, and right salpingo-oophorectomy was performed; there were numerous disseminated peritoneal tumors within the abdominal cavity. A few days postoperatively, massive...
Source: International Journal of Clinical Oncology - November 29, 2011 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: research

Mobilization and Harvesting of Peripheral Blood Stem Cells in Pediatric Patients With Solid Tumors
In conclusion, the collection of peripheral blood stem cells is an effective and safe procedure, even when conducted on the youngest children. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - November 25, 2011 Category: Hematology Authors: Dobrila VeljkovicDragana VujicOlivera Serbic NonkovicDragana JevticZeljko ZecevicEmilija Lazic Source Type: research

Paratesticular Yolk Sac Tumor
A 17-year-old male patient, no past medical history, presented with two-month history of left groin swelling with gradual increase in size and now pain. (Source: Diagnostic Imaging)
Source: Diagnostic Imaging - November 21, 2011 Category: Radiology Source Type: news

Surgical intervention strategies for pediatric ovarian tumors: experience with 60 cases at one institution
Conclusions The majority of pediatric ovarian tumors were benign disease, and the patients with malignant lesions had a good prognosis. In neonatal cases, an umbilical crease incision approach is feasible and provides excellent cosmesis. We recommend tumor resection with ovarian preservation through a minimally invasive approach (modified Rocky Davis incision) as the first line treatment for older pediatric patients with ovarian tumors other than those preoperatively diagnosed as malignant. Content Type Journal ArticleCategory Original articlePages 1-5DOI 10.1007/s00383-011-3004-3Authors Tatsuro Ta...
Source: Pediatric Surgery International - November 16, 2011 Category: Surgery Tags: Pediatric Surgery International Source Type: research

Primary Yolk Sac Tumor of the Urachus
Conclusion. An unusual case of a YST in the urachus is presented. This is the first reported adult case based on the authors’ bibliographic search. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - November 15, 2011 Category: Pathology Authors: Romero-Rojas, A. E., Messa-Botero, O. A., Melo-Uribe, M. A., Diaz-Perez, J. A., Chinchilla-Olaya, S. I. Tags: Case Reports Source Type: research

Yolk-Sac Tumor of the Postauricular Region: Case Report and Review of the Literature
The yolk-sac tumor (YST; or endodermal sinus tumor [EST]) is a malignant germ cell tumor that usually occurs in the gonads. This tumor is considered one of the most common tumors in infants and children. The extragonadal presentation of an YST is not common and the mechanism of germ cell misplacement is not well understood. In the head and neck, these tumors usually are found in the central nervous system. A non-midline YST is very rare and most cases have been reported in the neck, nasopharynx, and oral cavity. The treatment of choice is chemotherapy followed by surgical resection or radiotherapy. To the authors' knowledg...
Source: Journal of Oral and Maxillofacial Surgery - November 14, 2011 Category: ENT & OMF Authors: Navid Ahmady Rozbahany, Mohsen Hasanzadazar, Hassan Latifi, Afshin Mohammadi, Behroz Ilkhanizadeh, Mohammad Ghasemi-Rad Tags: Pathology Source Type: research

Case report of death from falling: Did heart tumor cause syncope?
Abstract A healthy man in his 30s was working on the balustrade of stairs on the second floor. He suddenly fell downstairs without saying anything. On emergency hospitalization, chest echogram showed left hemothorax. Cardiac echogram showed a floating mass from the mitral valve in the left ventricle and severe mitral regurgitation. Surgery for hemothorax and pulmonary contusion was immediately undertaken. However, bleeding from pulmonary contusion could not be controlled and he underwent cardiopulmonary arrest. Autopsy showed a white, elastic, pendulous mass in the left atrium and a white mass in the lower l...
Source: International Journal of Legal Medicine - November 12, 2011 Category: Medical Law Tags: International Journal of Legal Medicine Source Type: research

α-Fetoprotein–producing ovarian tumor in a postmenopausal woman with germ cell differentiation
Abstract: α-Fetoprotein (AFP)–producing ovarian tumors (APOTs) are rarely encountered in postmenopausal women, irrespective of whether they are of the germ cell or non–germ cell type. The APOTs that do occur in postmenopausal women are characterized by variable histologies such as hepatoid carcinoma, yolk sac tumor, and epithelial malignancies, most of which are combined. We herein present a case with APOT, which arose in a 58-year-old, gravida 2, para 2, postmenopausal woman. Preoperatively, the tumor, which was in the right ovary, was found to produce AFP (102768.0 ng/mL). The tumor was evenly composed of glands mim...
Source: Annals of Diagnostic Pathology - November 7, 2011 Category: Pathology Authors: Shiori Meguro, Masanori Yasuda Tags: Case Reports Source Type: research

Yolk sac tumours revisited. A review of their many faces and names
Nogales FF, Preda O & Nicolae A (2011) HistopathologyYolk sac tumours revisited. A review of their many faces and namesWe review the current knowledge on human yolk sac tumours (YSTs) 50 years after their initial description. Their complex nomenclature and histogenesis stress the fact that they are not a discrete entity, but represent a multifaceted group of neoplasms, for which the term primitive endodermal tumours would be more appropriate, accounting for their capacity to differentiate into various extraembryonal and somatic cell types. Different histological patterns of human YSTs correlate with the development...
Source: Histopathology - October 18, 2011 Category: Pathology Authors: Francisco F NogalesOvidiu PredaAlina Nicolae Tags: REVIEW Source Type: research

Preservation of Pregnancy in a Patient With Acute Abdominal Pain Secondary to Advanced and Hemorrhagic Yolk Sac Tumor of the Right Ovary [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 18, 2011 Category: Cancer & Oncology Authors: Viana, Tsunoda, Nunes, Fregnani, Vieira, Borges, Andrade, Serrano Tags: Combined Modality, MRI DIAGNOSIS IN ONCOLOGY Source Type: research