Bone Marrow Aspiration and BiopsyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Bone marrow biopsy and aspiration: What you can expectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone marrow biopsy and aspiration — Overview covers definition, risks, results of these procedures. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - November 20, 2009 Category: Consumer Health News Source Type: news

Diagnosis of childhood cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Childhood cancer is uncommon but remains the leading cause of disease-related death in children. Symptoms are often vague or insidious; they may suggest a more common alternative diagnosis, and they are quite different from those associated with adult malignancy. The skilled office practitioner must consider cancer as a diagnosis when symptoms/signs persist or when multiple symptoms point toward a possible diagnosis of malignancy. Early diagnosis is critical, as survival rates have increased dramatically over the past decades. Prolonged delay in diagnosis is common, especially for brain tumors and certain lymphomas (Ho...
Source: Primary Care - November 17, 2009 Category: Primary Care Authors: Raab CP, Gartner JC Tags: Prim Care Source Type: journals

Bone marrow aspiration enhances detection of leukemia cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists in New Mexico are experimenting with a nanotechnology device that quantifies the amount of nanoparticle-bound tumor cells in a tissue sample and offers increased sensitivity to minimal residual disease (Cancer Res 69:6839-6847, 2009). (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info

Mistletoe therapy as a therapeutic option in a child with lymphomatoid papulosis/CD 30-positive cutaneous lymphoproliferative papulosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion we present a patient with a rare skin disease (LP) with lymph node involvement who is successful treated with mistletoe as a new promising therapeutic option for patients with lymphomatoid papulosis. Further studies should be initiated. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: G. Kameda, K. Michael, A. Längler Source Type: journals

[Neonatal Pearson syndrome. Two case studies.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two diagnosed cases of Pearson syndrome in the early neonatal period caused by severe macrocytic aregenerative anemia. Bone marrow aspiration revealed sideroblastic anemia and vacuolization of erythroblastic precursors. The diagnosis was confirmed by genetic analysis revealing a deletion in the mitochondrial DNA. These two newborns received monthly transfusions. Five other newborns suffering from Pearson syndrome with various clinical symptoms were found in literature. Pearson syndrome, rarely diagnosed in newborns, should be suspected in the presence of macrocytic aregenerative anemia and requires a bone marro...
Source: Archives de Pediatrie - November 12, 2009 Category: Pediatrics Authors: Collin-Ducasse H, Maillotte AM, Monpoux F, Boutté P, Ferrero-Vacher C, Paquis V Tags: Arch Pediatr Source Type: journals

An interesting diagnosis for a presacral mass: Case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present an unusual cause of a presacral mass being extramedullary haematopoiesis, found incidentally in a 71 year old female. Extramedullary haematopoiesis is defined as the production of myeloid and erythroid elements outside of the bone-marrow. This diagnosis is extremely rare in the presacral area especially in a patient with no haematological abnormalities. A review of the literature is presented. (Source: International Seminars in Surgical Oncology)
Source: International Seminars in Surgical Oncology - November 8, 2009 Category: Surgery Authors: Sina BabazadehMatthew BroadheadJohn SlavinPeter Choong Source Type: journals

Morphological evaluation of monocytes and monocyte precursors in bone marrow trephine biopsies - need for establishing diagnostic criteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19880784 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Naresh KN Tags: Haematologica Source Type: journals

Crystal-storing histiocytosis as a cause of symptomatic cardiac mass.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a 64-year-old man with a prior history of weakness and weight loss and hematologic evaluation that had revealed immunoglobulin G kappa monoclonal light chains in the serum and negative bone marrow biopsy. He presented with supraventricular tachyarrhythmia and a right atrial mass seen on echocardiogram and excised surgically. Histologically, the tumor was composed of sheets of macrophages infiltrating the atrial myocardium. The histiocytes were filled with multiple needle-shaped, periodic acid-Schiff-negative crystals. These cells and associated plasma cells failed to show clonal light chain restriction by in sit...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Sailey CJ, Alexiev BA, Gammie JS, Pinell-Salles P, Stafford JL, Burke A Tags: Arch Pathol Lab Med Source Type: journals

Severe thrombocytopenia in a patient with metastatic renal cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although very rare, bone marrow carcinosis can occur in patients with mRCC and may present a diagnostic challenge. It is associated with a very poor prognosis. PMID: 19887872 [PubMed - in process] (Source: Onkologie)
Source: Onkologie - November 1, 2009 Category: Cancer & Oncology Authors: Florcken A, Loew A, Koch M, Gebauer B, Dorken B, Riess H Tags: Onkologie Source Type: journals

A Case of Myelodysplastic Syndrome in a Liver Transplant PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the second known case of MDS after OLT. Case reports of MDS in OLT were identified using PubMed. Patient data were gathered from the patient and the medical record.A 54-year-old Caucasian man underwent OLT in 2003 and again in 2004 for hepatitis C–related cirrhosis. In 2007, the patient developed weakness, malaise, and shortness of breath. Laboratory studies revealed pancytopenia. Bone marrow biopsy showed MDS, with refractory anemia and excess blasts-1. The patient underwent chemotherapy and reduction in immunosuppression without a clinical response.Our experience suggested that MDS, although rare, should be ...
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: R. Potru, J. Ahn, H. Fung, S.M. Cohen Tags: Case Reports Source Type: journals

Rare orbitocranial tumour in an adult.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 35-year-old lady presented with recurrent episodes of painful right upper lid swelling and ptosis of 6 months' duration. The symptoms would subside with oral antibiotics and painkillers. She had also been undergoing treatment for 1 year for multiple painful osteolytic lesions in the long bones and axial skeleton for which no definite diagnosis had been made, despite several radiological and serological investigations having been performed. Computed tomographic scan showed a soft tissue lesion in the superolateral part of the right orbit with erosion of the adjacent bone. Lacrimal gland biopsy showed non-specific infl...
Source: Orbit - October 31, 2009 Category: Opthalmology Authors: Mehta A, Chandra M Tags: Orbit Source Type: journals

Diagnosis of progressive disseminated histoplasmosis on bone marrow biopsy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19876705 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 31, 2009 Category: Hematology Authors: Shah BK, Serban K, Tandon M Tags: Int J Hematol Source Type: journals

Making the most of bone marrow trephine biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wilkins B S & Clark D M (2009) HistopathologyMaking the most of bone marrow trephine biopsy Bone marrow trephine biopsy is an integral component of the diagnosis, staging and follow-up of many haematological diseases. Adequate size and integrity of the initial specimen are crucial, although data defining what constitutes an adequate sample in different clinical contexts are limited. The requirement for decalcification or plastic embedding during tissue processing poses additional challenges for histological quality and successful application of essential techniques, including immunohistochemistry, DNA/RNA in situ hybridiza...
Source: Histopathology - October 30, 2009 Category: Pathology Authors: Bridget S Wilkins, David M Clark Source Type: journals

Enhanced Leukemia Cell Detection Using a Novel Magnetic Needle and NanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute leukemia is a hematopoietic malignancy for which the accurate measurement of minimal residual disease is critical to determining prognosis and treatment. Although bone marrow aspiration and light microscopy remain the current standard of care for detecting residual disease, these approaches cannot reliably discriminate less than 5% lymphoblast cells. To improve the detection of leukemia cells in the marrow, we developed a novel apparatus that utilizes antibodies conjugated to superparamagnetic iron oxide nanoparticles (SPION) and directed against the acute leukemia antigen CD34, coupled with a "magnetic needle" biops...
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Jaetao, J. E., Butler, K. S., Adolphi, N. L., Lovato, D. M., Bryant, H. C., Rabinowitz, I., Winter, S. S., Tessier, T. E., Hathaway, H. J., Bergemann, C., Flynn, E. R., Larson, R. S. Tags: Clinical Research Source Type: journals

Macrophage activation syndrome in juvenile systemic lupus erythematosus: A multinational multicenter study of thirty-eight patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To describe the clinical and laboratory features of macrophage activation syndrome as a complication of juvenile systemic lupus erythematosus (SLE).Cases of juvenile SLE-associated macrophage activation syndrome were provided by investigators belonging to 3 pediatric rheumatology networks or were found in the literature. Patients who had evidence of macrophage hemophagocytosis on bone marrow aspiration were considered to have definite macrophage activation syndrome, and those who did not have such evidence were considered to have probable macrophage activation syndrome. Clinical and laboratory findings in patients with mac...
Source: Arthritis and Rheumatism - October 29, 2009 Category: Rheumatology Authors: Alessandro Parodi, Sergio Davì, Alejandra Beatriz Pringe, Angela Pistorio, Nicolino Ruperto, Silvia Magni-Manzoni, Paivi Miettunen, Brigitte Bader-Meunier, Graciela Espada, Gary Sterba, Seza Ozen, Dowain Wright, Claudia Saad Magalhães, Raju Khubchandani Tags: Childhood Arthritis Source Type: journals

The significance of tumour cell immunophenotype in myeloma and its impact on clinical outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Immunophenotype impacts on clinical outcome in MM. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Ngo, N-T, Brodie, C, Giles, C, Horncastle, D, Klammer, M, Lampert, I A, Rahemtulla, A, Naresh, K N Tags: Immunology (including allergy), Clinical diagnostic tests Original articles Source Type: journals

Extent of disease burden determined with magnetic resonance imaging of the bone marrow is predictive of survival outcome in patients with multiple myelomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multiple myeloma (MM) remains an incurable cancer. Treatment often is initiated at the time patients experience a progressive increase in tumor burden. The authors of this report investigated magnetic resonance imaging of the bone marrow (BM-MRI) as a novel approach to quantify disease burden and validated a staging system by correlating BM-MRI with common clinical and laboratory parameters.The extent of bone marrow involvement was evaluated by BM-MRI. Clinical and laboratory parameters were assessed in patients with active MM, and correlations between variables were assessed statistically. Bone marrow involvement by BM-MR...
Source: Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Sikander Ailawadhi, Ahmed N. Abdelhalim, Lyudmyla Derby, Terry L. Mashtare, Kena C. Miller, Gregory E. Wilding, Ronald A. Alberico, Ronald Gottlieb, Donald L. Klippenstein, Kelvin Lee, Asher A. Chanan-Khan Source Type: journals

Natural course of HCV infection in childhood cancer survivorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The outcome of hepatitis C in our patients is comparable to the one described in European cohorts of adult cancer survivors and perinatally infected subjects. Nevertheless, progression to high degrees of hepatic damage has to be monitored by a careful follow-up. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0763-7Authors Francesca Fioredda, Giannina Gaslini Children’s Hospital Department of Pediatric Hematology, Oncology, and Bone Marrow Transplantation Largo Gerolamo Gaslini 5 16147 Genoa ItalyAndrea Moser, Medical University of Graz Division of Pediatric H...
Source: Supportive Care in Cancer - October 26, 2009 Category: Cancer & Oncology Tags: Supportive Care in Cancer Source Type: journals

Mikulicz's disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case of Mikulicz's disease (MD) occurring 2 years after autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma (MM). A 70-year-old man developed bilateral enlargement of parotid and submandibular glands. The patient had previously received 2 courses of autologous PBSCT for IgG-kappa type MM, and had been stable for 2 years. This salivary gland enlargement was initially felt to represent a recurrence of MM, since along with gland swelling, IgG was also elevated. However, repeated biopsy of the left submandibular gland revealed chronic sclerosing sialadenitis rather than plasma...
Source: International Journal of Hematology - October 24, 2009 Category: Hematology Authors: Sakurai C, Ohashi K, Sakaguchi K, Hishima T, Kamata N, Akiyama H, Sakamaki H Tags: Int J Hematol Source Type: journals

Keratotic vascular papules over the feet: a case of Waldenström's macroglobulinaemia-associated cutaneous macroglobulinosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Waldenström's macroglobulinaemia (WM) is a plasma-cell dyscrasia characterized by the monoclonal proliferation of lymphoplasmacytes. A 48-year-old man presented with a 4-year history of multiple painful, hyperkeratotic deep-seated papules over the pressure areas of both soles. He had a 1-year history of Raynaud's phenomenon, intermittent epistaxis, recurrent vomiting, tingling and numbness, and visual disturbances. Histological examination of a skin biopsy found amyloid-like deposits in the upper and mid dermis involving dermal blood vessels, but apart from periodic-acid[ndash]Schiff, various stains gave negative results ...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: M. Harnalikar, S. Pande, V. Kharkar, U. Khopkar Source Type: journals

Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The spinal epidural space is an uncommon presenting site in primary non-Hodgkin’s lymphomas, especially for children. A boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lymphoma. Thoracolumbar magnetic resonance imaging (MRI) demonstrated an intraspinal mass. An operation was performed with gross total tumor removal. Histological examination revealed a non-Hodgkin’s B-cell lymphoma. Bone marrow aspiration was negative for lymphoma involvement. No other therapies (chemotherapy and/or radiotherapy) were performed according to the parents’ opinion. T...
Source: Frontiers of Medicine in China - October 22, 2009 Category: Journals (General) Tags: Frontiers of Medicine in China Source Type: journals

Rare orbitocranial tumour in an adult.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 35-year-old lady presented with recurrent episodes of painful right upper lid swelling and ptosis of 6 months' duration. The symptoms would subside with oral antibiotics and painkillers. She had also been undergoing treatment for one year for multiple painful osteolytic lesions in the long bones and axial skeleton for which no definite diagnosis had been made, despite several radiological and serological investigations having been performed. Computed tomographic scan showed a soft tissue lesion in the superolateral part of the right orbit with erosion of the adjacent bone. Lacrimal gland biopsy showed non-specific in...
Source: Orbit - October 22, 2009 Category: Opthalmology Authors: Mehta A, Chandra M Tags: Orbit Source Type: journals

Myogenic differentiation of human bone marrow mesenchymal stem cells on a 3D nano fibrous scaffold for bladder tissue engineering.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current strategies for engineering bladder tissues include a bladder biopsy for in vitro cell expansion for use in reconstructive procedures. However, this approach cannot be used in patients with bladder cancer who need a complete bladder replacement. Bone marrow mesenchymal stem cells (BMSC) might be an alternative cell source to better meet this need. We investigated the effects of soluble growth factors, bladder extracellular matrix (ECM), and 3D dynamic culture on cell proliferation and differentiation of human BMSC into smooth muscle cells (SMC). Myogenic growth factors (PDGF-BB and TGF-beta1) alone, or combined ...
Source: Biomaterials - October 21, 2009 Category: Materials Science Authors: Tian H, Bharadwaj S, Liu Y, Ma H, Ma PX, Atala A, Zhang Y Tags: Biomaterials Source Type: journals

Role of endoscopic ultrasound-guided fine-needle aspiration with flow cytometry to diagnose lymphoma: A single center experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: EUS[minus]FNA is sensitive and specific for the diagnosis of suspected lymphoma. Confirmatory or further testing should be performed when EUS[minus]FNA with or without FC is indeterminate and or non-diagnostic. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - October 19, 2009 Category: Gastroenterology Authors: Mohammad Al-Haddad, Mojgan Sara Savabi, Stuart Sherman, Lee McHenry, Julia LeBlanc, Harvey Cramer, Robert Emerson, Jillian O'Neil, Mouen Khashab, John DeWitt Source Type: journals

Expansion of human mesenchymal stromal cells on microcarriers: growth and metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study selected a suitable microcarrier for human bone marrow-derived stromal cells (HBMSCs), optimized cell-seeding strategies by varying serum concentrations, and optimized dynamic expansion of the HBMSCs in a microcarrier-based spinner flask cultivation system by applying various feeding regimes. Cytodex 1 microcarriers in combination with a low-serum concentration (0-5%) in the medium resulted in the highest seeding efficiency for the HBMSCs. Subsequently, significant expansion of the HBMSCs on these carriers has been observed. The highest number of HBMSCs population doublings (4.8 doublings) was obtained by a comb...
Source: Journal of Tissue Engineering and Regenerative Medicine - October 18, 2009 Category: Molecular Biology Authors: D. Schop, R. van Dijkhuizen-Radersma, E. Borgart, F. W. Janssen, H. Rozemuller, H.-J. Prins, J. D. de Bruijn Source Type: journals

[Clinical Picture] Bone marrow involvement in Q fever—detection by fluorine-18-labelled fluorodeoxyglucose PETEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 60-year-old man was admitted to hospital with a 2-week history of fever, rigors, and headache. Apart from hypertension, his past medical history was unremarkable. He travelled abroad frequently, and had visited China where he had been exposed to a herd of goats 2 months before the current illness. On examination, he was pyrexial (38·5°C) and his liver was enlarged. His full blood count was normal, but his C-reactive protein was raised. Serum transaminases and alkaline phosphatase were mildly raised. Preliminary screening for auto-antibodies was negative. Initial parasitic and virological screening was also negative. Ce...
Source: The Lancet Infectious Diseases - October 18, 2009 Category: Infectious Diseases Authors: Lankanatha Alwis, Kottekkattu Balan, Penny Wright, Andrew Lever, Andrew Carmichael Tags: Clinical Picture Source Type: journals

Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immune reconstitution syndrome (IRS) is an increasingly common condition that has been described in immunosuppressed individuals once immune function is restored. In this case, we describe a patient who had a renal transplant and subsequently developed pulmonary histoplasmosis. His course was also complicated by the development of a clinical syndrome that was originally attributed to thrombocytopenic thrombotic purpura (TTP). When he did not improve with plasmapheresis and high dose prednisone, a bone marrow biopsy revealed disseminated histoplasmosis and administration of prednisone was rapidly tapered. While on 5 mg of p...
Source: Mycoses - October 14, 2009 Category: Research Authors: Alison Jazwinski, Susanna Naggie, John Perfect Source Type: journals

Hairy cell leukemia responsive to anti-thymocyte globulin used as immunosuppressive therapy for aplastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia (HCL) is occasionally misdiagnosed as aplastic anemia when only a few leukemic cells are present in the circulation. Here, we describe a patient with HCL who initially presented with pancytopenia and received a diagnosis of aplastic anemia. The patient was treated with immunosuppressive therapy including cyclosporine A and anti-thymocyte globulin (ATG). No blood cell transfusion was required for approximately 3 years after ATG therapy. She was referred to our hospital because of an abdominal mass and requiring periodic blood transfusions. A bone marrow biopsy at this time revealed proliferation of l...
Source: International Journal of Hematology - October 13, 2009 Category: Hematology Authors: Fujiwara S, Miyake H, Nosaka K, Yoshida M, Ishihara S, Horikawa K, Yonemura Y, Iyama K, Mitsuya H, Asou N Tags: Int J Hematol Source Type: journals

High-sensitivity Bone Marrow Aspiration Technology Enhances Leukemia Cell DetectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists have created a viable technology to improve the detection of leukemia cells in bone marrow. Superconducting Quantum Interference Device (SQUID) enhanced the ability to rapidly quantify the amount of nanoparticle bound tumor cells in a sample at least 10 fold, and increased sensitivity of minimal residual disease measurements. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 8, 2009 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Leukemia Cell Detection Enhanced By High-Sensitivity Bone Marrow Aspiration TechnologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists have created a viable technology to improve the detection of leukemia cells in bone marrow. Superconducting Quantum Interference Device (SQUID) enhanced the ability to rapidly quantify the amount of nanoparticle bound tumor cells in a sample at least 10 fold, and increased sensitivity of minimal residual disease measurements. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 8, 2009 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

18F-FDG-PET findings of rare case of nonsecretory plasmablastic myelomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a rare case of nonsecretory plasmablastic myeloma detected by 18F-FDG-PET. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12149-009-0300-2Authors Hiroko Kaibara, Kurume University School of Medicine Division of Nuclear Medicine, PET Center and Department of Radiology 67 Asahi-machi Kurume Fukuoka 830-0011 JapanHayato Kaida, Kurume University School of Medicine Division of Nuclear Medicine, PET Center and Department of Radiology 67 Asahi-machi Kurume Fukuoka 830-0011 JapanMasatoshi Ishibashi, Kurume University School of Medicine Division of Nuclear Medicine, PET Center and Department of Radiol...
Source: Annals of Nuclear Medicine - October 8, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

Bone Marrow Biopsy Needles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 142DOI: 10.1097/01.BMSAS.0000361709.25721.98 (Source: Biomedical Safety & Standards)
Source: Biomedical Safety & Standards - October 7, 2009 Category: Medical Equipment Tags: HTML PDF (582 K) Source Type: journals

Bone Marrow Aspiration and BiopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Figure Bone marrow aspiration is performed to assess cellular morphology and to conduct tests on the bone marrow. Bone marrow biopsy is often performed in tandem to provide information about the marrow and the extent of disease. This video demonstrates both procedures. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - October 6, 2009 Category: Internal Medicine Authors: Malempati, S., Joshi, S., Lai, S., Braner, D. A.V., Tegtmeyer, K. Tags: VIDEOS IN CLINICAL MEDICINE Source Type: journals

Nodular pattern of bone marrow infiltration: frequent finding in immunosuppression-related EBV-associated large B-cell lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Different patterns of bone marrow (BM) infiltration by diffuse large B cell lymphomas (DLBCL) have been described. A pure nodular pattern is uncommon, and the pathologic features, as well as the clinical correlates of DLBCL manifesting this pattern in the BM have not been well characterized. We evaluated BM biopsies involved by large B cell lymphomas diagnosed at our institute over an 11-year period to assess the morphology, phenotype, cytogenetic abnormalities, and clinical features of cases associated with a nodular pattern. A distinct nodular pattern of BM involvement was noted in 14 out of 55 (2...
Source: Virchows Archiv - October 6, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

High-sensitivity bone marrow aspiration technology enhances leukemia cell detectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(American Association for Cancer Research) Scientists have created a viable technology to improve the detection of leukemia cells in bone marrow. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 6, 2009 Category: Biology Source Type: news

Complete remission of splenic marginal zone lymphoma after an acute flare-up of hepatitis B in a hepatitis B virus carrier.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 44-year-old female presented with asymptomatic leukocytosis and moderate splenomegaly. The diagnosis of splenic marginal zone lymphoma (SMZL) was made by a splenectomy. A virological examination revealed the patient to be a hepatitis B virus (HBV) carrier. The lymphocyte count in her peripheral blood decreased after splenectomy, but remained high for 2 years and bone marrow infiltration was obvious. Two years after the splenectomy, she was admitted for an acute flare-up of hepatitis B. The liver dysfunction improved without any medication and thereafter returned to the normal range within a few weeks. At the same tim...
Source: International Journal of Hematology - October 5, 2009 Category: Hematology Authors: Fujimoto K, Endo T, Nishio M, Obara M, Yamaguchi K, Takeda Y, Goto H, Kasahara I, Sato N, Koike T Tags: Int J Hematol Source Type: journals

Enhanced Leukemia Cell Detection Using a Novel Magnetic Needle and Nanoparticles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute leukemia is a hematopoietic malignancy for which the accurate measurement of minimal residual disease is critical to determining prognosis and treatment. Although bone marrow aspiration and light microscopy remain the current standard of care for detecting residual disease, these approaches cannot reliably discriminate less than 5% lymphoblast cells. To improve the detection of leukemia cells in the marrow, we developed a novel apparatus that utilizes antibodies conjugated to superparamagnetic iron oxide nanoparticles (SPION) and directed against the acute leukemia antigen CD34, coupled with a "magnetic needle" b...
Source: Cell Research - October 5, 2009 Category: Cytology Authors: Jaetao JE, Butler KS, Adolphi NL, Lovato DM, Bryant HC, Rabinowitz I, Winter SS, Tessier TE, Hathaway HJ, Bergemann C, Flynn ER, Larson RS Tags: Cancer Res Source Type: journals

Bendamustine-Associated Hemolytic Anemia (November).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Continued monitoring of postmarketing data is necessary to correlate this occurrence of hemolytic anemia with bendamustine therapy. PMID: 19809007 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 5, 2009 Category: Drugs & Pharmacology Authors: Glance LE, Cumpston A, Kanate A, Remick SC Tags: Ann Pharmacother Source Type: journals

Primary sciatic nerve lymphoma: A case report of a tumor in a rare location with MR findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The peripheral nerves are a very rare site of origin for primary lymphoma. A 52-year-old man presented with progressive paresthesias and numbness of the right lower extremity, associated with radiating pain from the posterior thigh to the foot. Electromyogram indicated nerve origin impairment the right lower extremity. Emission computed tomography; chest computed tomography; abdominal ultrasound and bone marrow biopsy were performed to exclude a systemic lymphoma. Magnetic resonance imaging studies revealed a solitary fusiform mass along the right sciatic nerve, at last pathological examination confirmed the prim...
Source: European Journal of Radiology Extra - October 5, 2009 Category: Radiology Authors: Zhi-qun Wang, Yan-qing Dong, Kun-cheng Li Source Type: journals

The role of bone marrow-derived mesenchymal stem cells in treating formocresol induced oral ulcers in dogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Mesenchymal stem cells transplantation may help accelerate oral ulcer healing, possibly through the induction of angiogenesis by VEGF together with increased intracellular matrix formation as detected by increased collagen gene expression. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - October 3, 2009 Category: Pathology Authors: H. El-Menoufy, L. A. A. Aly, M. T. A. Aziz, H. M. Atta, N. K. Roshdy, L. A. Rashed, D. Sabry Source Type: journals

Acute myelogenous leukemia in a child with HIV infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The occurrence of acute myelogenous leukemia (AML) in HIV-infected patients is extremely rare with only adult patients reported so far. Our patient was a 7-year-old male who presented with fever and cough since 1 month with six episodes of intermittent hemoptysis. The child also had recurrent parotid swellings, melena, and purulent otitis media. Investigations revealed anemia (hemoglobin of 8.9 g/dl), thrombocytopenia (platelet count of 21,000 cells per microliter), and positive HIV antibody (perinatal transmission). The patient's bone marrow aspiration and biopsy suggested AML, and the le...
Source: European Journal of Pediatrics - October 3, 2009 Category: Pediatrics Tags: European Journal of Pediatrics Source Type: journals

Concurrent langerhans cell histiocytosis and B-lineage lymphoid proliferation in the bone marrow.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report three rare cases of concurrent bone marrow involvement of LCH and B-lineage lymphoid proliferation, which strongly suggest lymphoid malignancy. Further, clonal changes should be studied to elucidate the common pathogenic mechanism between the two diseases. PMID: 19893348 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)
Source: The Korean Journal of Laboratory Medicine - October 1, 2009 Category: Laboratory Medicine Authors: Kim M, Kang HJ, Shin HY, Ahn HS, Lee DS Tags: Korean J Lab Med Source Type: journals

Discrepant Immunophenotypic Characteristics between the Lymph Node and Bone Marrow in Two Mixed-Phenotype Acute Leukemia Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immunophenotypic profile of hematological malignancies is usually consistent among different sites of involvement; this consistency allows reliable diagnosis from peripheral blood, bone marrow, or lymph node, especially in cases of acute leukemia. Although in a minority of lymphoma patients, two or more different populations with discordant immunophenotypes have been described, either at the same or distinct sites. Here, we report two Korean patients with acute leukemia where the results of immunophenotypic analysis of the bone marrow specimen were different from those of immunohistochemical studies of a biopsy sam...
Source: The Korean Journal of Laboratory Medicine - October 1, 2009 Category: Laboratory Medicine Authors: Song MJ, Kim HJ, Ko YH, Kim SH Tags: Korean J Lab Med Source Type: journals

Megakaryocytic alterations in thrombocytopenia: a bone marrow aspiration study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Careful understanding of the morphological changes of megakaryocytes in bone marrow aspirates can improve the diagnostic accuracy for a wide range of hematological disorders thereby enabling proper therapeutic interventions. PMID: 19805953 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Muhury M, Mathai AM, Rai S, Naik R, Pai MR, Sinha R Tags: Indian J Pathol Microbiol Source Type: journals

The sternoclavicular joint: can imaging differentiate infection from degenerative change?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The clinical and imaging findings significantly associated with sternoclavicular joint infection included joint capsule distention of 10 mm or greater, extension over both the clavicle and sternum, adjacent fluid signal bone marrow replacement, elevated Westergren red blood cell sedimentation rate, and fever. Content Type Journal ArticleCategory Scientific ArticleDOI 10.1007/s00256-009-0802-yAuthors Mark C. Johnson, University of Michigan Department of Radiology 1500 East Medical Center Drive, TC-2910L Ann Arbor MI 48109-0326 USAJon A. Jacobson, University of Michigan Department of Rad...
Source: Skeletal Radiology - September 30, 2009 Category: Radiology Tags: Skeletal Radiology Source Type: journals

A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The combination of 5-AC and phenylbutyrate across three dose schedules was generally well tolerated and safe, yet lacked any real evidence for clinical benefit. (Clin Cancer Res 2009;15(19):6241-9). PMID: 19789320 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 28, 2009 Category: Cancer & Oncology Authors: Lin J, Gilbert J, Rudek MA, Zwiebel JA, Gore S, Jiemjit A, Zhao M, Baker SD, Ambinder RF, Herman JG, Donehower RC, Carducci MA Tags: Clin Cancer Res Source Type: journals

Recent advances in bone marrow biopsy pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The second quarter of 2009 saw steady advances in bone marrow biopsy (BMB) pathology. The following publications are a personal selection of the highlights. Quality issues in diagnostic immunohistochemistry for BMB have largely been ignored in external quality assurance programmes, and this issue is highlighted. In other areas, publications reflecting advances in flow cytometry and aspirate morphology are discussed where translation to the BMB is possible. Classifications undergo constant change, and several publications address the redefinition of the cut off points between malignancy, benign, and ...
Source: Journal of Hematopathology - September 28, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Deletions of chromosome arms 7p and 7q in adult acute myeloid leukemia: a marker chromosome confirmed by array comparative genomic hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Acute myeloid leukemia (AML) cases with monosomy 7 (−7) and del(7q) comprise a heterogeneous subgroup. The association of losses in 7q with myeloid leukemia suggests that this region contains a tumor suppressor gene or genes whose loss of function contributes to leukemic transformation or tumor progression. The −7/del(7q) aberrations frequently coexist with complex karyotypes such as −5/del(5q) and trisomy 8. In the present case, we identified a rare abnormality involving deletion of both arms of chromosome 7 presenting with a marker chromosome-like appearance in an AML patient. Bone marrow aspiration and b...
Source: Cancer Genetics and Cytogenetics - September 24, 2009 Category: Genetics & Stem Cells Authors: Kwang-Sook Woo, Kyung-Eun Kim, Kyeong-Hee Kim, Sung-Hyun Kim, Joo-In Park, Lisa G. Shaffer, Jin-Yeong Han Tags: Original articles Source Type: journals

Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone marrow examination has become increasingly important for the diagnosis and treatment of hematologic and other illnesses. Morphologic evaluation of the bone marrow aspirate and biopsy has recently been supplemented by increasingly sophisticated ancillary assays, including immunocytochemistry, cytogenetic analysis, flow cytometry, and molecular assays. With our rapidly expanding knowledge of the clinical and biologic diversity of leukemia and other hematologic neoplasms, and an increasing variety of therapeutic options, the bone marrow examination has became more critical for therapeutic monitoring and planning optimal ...
Source: Journal of Clinical Laboratory Analysis - September 23, 2009 Category: Laboratory Medicine Authors: Roger S. Riley, David Williams, Micaela Ross, Shawn Zhao, Alden Chesney, Bradly D. Clark, Jonathan M. Ben-Ezra Tags: Original Articles Source Type: journals