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Cost Effectiveness of Herpes Zoster Vaccine in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PharmacoEconomics)
Source: PharmacoEconomics - November 16, 2009 Category: Health Management Authors: Najafzadeh, MehdiMarra, Carlo A.Galanis, EleniPatrick, David M. Tags: Original Research Articles Source Type: journals

Pseudolymphomatous reaction to varicella zoster virus vaccination: role of viral in situ hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 61-year-old female on immunosuppressant medications for rheumatoid arthritis who presented with a subcutaneous nodule at the site of a recent herpes zoster vaccination. Histopathological examination revealed a dense nodular and interstitial mononuclear infiltrate throughout the mid and deep dermis with extension into the superficial subcutaneous fat. Immunohistochemical staining revealed an admixture of T-cells and B-cells, with a predominance of T-cells. These findings are consistent with a pseudolymphoma (PL), a reactive inflammatory disorder that can resemble cutaneous lymphoma and has rarely been described ...
Source: Journal of Cutaneous Pathology - November 4, 2009 Category: Pathology Authors: Dennis A. Porto, Nneka I. Comfere, Laura M. Myers, Jared J. Abbott Source Type: journals

Neurologic manifestations of varicella zoster virus infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Varicella zoster virus (VZV) causes acute viral exanthema in childhood, becomes latent, and can reactivate years later to produce neurologic disease. Primary VZV infection is associated with acute cerebellitis and stroke, particularly in childhood. VZV reactivation may result in neuropathy, myelitis, stroke, and encephalitis, the latter two syndromes the result of small and large vessel vasculopathy. Prompt diagnosis and treatment are critical to minimize morbidity in herpes zoster as well as morbidity and death in VZV vasculitis and encephalitis. Detection of anti-VZV antibodies in cerebrospinal fl...
Source: Current Neurology and Neuroscience Reports - October 13, 2009 Category: Neuroscience Tags: Current Neurology and Neuroscience Reports Source Type: journals

Interferon-gamma release assay: A simple method for detection of varicella-zoster virus-specific cell-mediated immunity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes zoster is closely related to decreased varicella-zoster virus (VZV)-specific cell-mediated immunity. We validated a new assay for measuring VZV-specific immunity. We cultured the whole blood of healthy subjects with live attenuated VZV vaccine. Culture supernatants were harvested at 24-h intervals and assayed for interferon-gamma (IFN-gamma) by an enzyme-linked immunosorbent assay (ELISA). The 48-h culture was suitable for estimating IFN-gamma release. IFN-gamma production was stable after standing for at least 4h at room temperature. IFN-gamma production was observed in whole blood from subjects with recent VZV...
Source: Journal of Immunological Methods - October 6, 2009 Category: Allergy & Immunology Authors: Otani N, Baba K, Okuno T Tags: J Immunol Methods Source Type: journals

Transmission of varicella vaccine virus, Japan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report secondary transmission of the vOka strain from an immunocompetent girl with a history of varicella vaccination to her healthy susceptible brother. PMID: 19861086 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 1, 2009 Category: Infectious Diseases Authors: Otsuka T, Gomi Y, Inoue N, Uchiyama M Tags: Emerg Infect Dis Source Type: journals

Stop shingles in its tracks.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Initiate antiviral treatment as soon as possible; rapid resolution of acute pain and reduction in the development of postherpetic neuralgia (PHN) are most likely when therapy is started within 72 hours of the outbreak. Discuss herpes zoster (HZ) vaccination with healthy patients 60 years of age and older during their first office visit; the vaccine markedly reduces the incidence of HZ and PHN. Do not prescribe tricyclic antidepressants or corticosteroids in the acute phase of HZ. PMID: 19874731 [PubMed - in process] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - October 1, 2009 Category: Practice Management Authors: Lang PO, Hasso Y, Michel JP Tags: J Fam Pract Source Type: journals

Zoster Risk Sharply Reduced After Varicella VaccinationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
VAIL, Colo. — The risk of herpes zoster in children under age 10 years who've been vaccinated against varicella was 4- to 12-fold less than in those with naturally acquired varicella in a large population-based study. (Source: Skin and Allergy News)
Source: Skin and Allergy News - September 30, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: Infectious Diseases Source Type: journals

More Zoster Vaccine May Help Protect Elderly PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell-mediated immunity plays a crucial role in resistance to herpes zoster in elderly patients, and giving more or higher doses of the zoster vaccine may boost the immune response, researchers report in the October 1st issue of the Journal of Infectious Diseases. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 29, 2009 Category: Consumer Health News Tags: Infectious Diseases Source Type: news

Shingles vaccine now available for seniorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new vaccine against shingles is now available across Canada for people over the age of 60, says the vaccine's maker, Merck Frosst Canada. (Source: CBC | Health)
Source: CBC | Health - September 22, 2009 Category: Consumer Health News Source Type: news

Shingles vaccine Zostavax arrives in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Canadian seniors can now help protect themselves against the intensely painful condition called shingles by getting a vaccine that becomes available today. (Source: CTV Health)
Source: CTV Health - September 22, 2009 Category: Consumer Health News Source Type: news

Evaluation of the cost-effectiveness in the United States of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A structured abstract written by CRD reviewers. The abstract was published on 19 August 2009 from an original article published in 2007. (Source: Neurological Conditions Specialist Library)
Source: Neurological Conditions Specialist Library - September 10, 2009 Category: Neurology Source Type: organizations

Zoster Vaccine Could Have Off-Label UseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
VAIL, COLO. — Giving herpes zoster vaccine to children who are immunocompromised, or are about to become so, is an off-label use that is nonetheless worthy of strong consideration in selected cases. (Source: Skin and Allergy News)
Source: Skin and Allergy News - August 31, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: Pediatric Dermatology Source Type: journals

Varicella‐Zoster Virus–Specific Immune Responses to Herpes Zoster in Elderly Participants in a Trial of a Clinically Effective Zoster VaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Higher VZV CMI at HZ onset was associated with reduced HZ severity and less postherpetic neuralgia. Higher antibody titers were associated with increased HZ severity and occurrence of postherpetic neuralgia. HZ and zoster vaccine generated comparable VZV CMI. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - August 27, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Postherpetic neuralgia in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ) or 'shingles' and affects a significant proportion of HZ patients with the disease, with the elderly being most frequently and seriously affected. Characterised by various types of pain (constant, intermittent and stimulus evoked) that persist between 3 months and many years after the resolution of the HZ rash, PHN can have a severe impact on the patient's quality of life and functional ability. PHN remains highly resistant to current treatments. In this review, we discuss the epidemiology, clinical features and management of PHN in the ...
Source: Herpes - August 22, 2009 Category: Infectious Diseases Authors: Johnson RW, McElhaney J Tags: Int J Clin Pract Source Type: journals

ZOSTAVAX (Zoster Vaccine Live) Injection, Powder, Lyophilized, For Suspension STERILE DILUENT (Sterile Water) Injection [Merck Co., Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Aug 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - August 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

Flu's Not the Only Ill That Might Merit a Preventive ShotEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All the vaccine buzz is about the H1N1 virus right now, but the Centers for Disease Control and Prevention is reminding Americans to make sure all of their vaccinations are up-to-date. The CDC encourages adults to guard against vaccine-preventable diseases such as shingles, human papillomavirus... (Source: Wash Post Health)
Source: Wash Post Health - August 18, 2009 Category: Consumer Health News Authors: Rachel Saslow Tags: Flu's Not the Only Ill That Might Merit Preventive Shot Source Type: news

Varicella zoster virus vaccine live: Herpes zoster and meningitis in a child: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - July 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Varicella zoster virus vaccines: effective, but concerns linger.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Both varicella and herpes zoster (HZ) can cause severe disease in certain age groups. The cell-mediated immune (CMI) response to the varicella zoster virus (VZV) is critical in preventing a recurrence of VZV. The varicella vaccine has markedly decreased the morbidity and mortality associated with varicella, but concerns linger about the cost and frequency of vaccine administration and the long-term effects on both adult varicella and HZ epidemiology in the individual and in the population. Therapy for HZ with an antiviral is only partially effective. A zoster vaccine is now available that boosts the CMI immune reaction...
Source: Canadian Journal of Ophthalmology - July 18, 2009 Category: Opthalmology Authors: Liesegang TJ Tags: Can J Ophthalmol Source Type: journals

Varicella zoster virus vaccine live: Herpes zoster and meningitis in a child: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 29 (Source: Reactions Weekly)
Source: Reactions Weekly - July 18, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

A phase i-ii study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A PHASE I-II STUDY OF LIVE ATTENUATED VARICELLA-ZOSTER VIRUS VACCINE TO BOOST IMMUNITY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN WITH PREVIOUS VARICELLA. Pediatr Infect Dis J. 2009 Jul;28(7):653-655 Authors: Gershon AA, Levin MJ, Weinberg A, Song LY, Larussa PS, Steinberg SP, Bartlett P, Herpes zoster, may be severe and recurrent in HIV-infected children. We determined the safety and immunogenicity of live attenuated varicella-zoster virus (VZV) vaccine in 46 HIV-infected children who had experienced varicella. There were no serious adverse events. Two years after vaccination 82% of subjects remained V...
Source: Herpes - June 30, 2009 Category: Infectious Diseases Authors: Gershon AA, Levin MJ, Weinberg A, Song LY, Larussa PS, Steinberg SP, Bartlett P, Tags: Pediatr Infect Dis J Source Type: journals

CLINICAL CROSSROADS: A 70-Year-Old Woman With Shingles: Review of Herpes ZosterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes zoster is a common late complication of varicella-zoster virus exposure and can be further complicated by postherpetic neuralgia. Ms A is a 70-year-old woman with shingles and Ramsay-Hunt syndrome who presented to the emergency department with a few days of earache followed by pain in the back of her head. Using her case as a springboard, the diagnosis, natural history, and treatment of herpes zoster and postherpetic neuralgia in immunocompetent older adults are reviewed, in addition to the effectiveness of the herpes zoster vaccine. (Source: JAMA)
Source: JAMA - June 29, 2009 Category: Journals (General) Authors: Whitley, R. J. Tags: Aging/ Geriatrics, Viral Infections, Neurology, Neuromuscular diseases, Otolaryngology/ Head & Neck Surgery, Middle/ External Ear Disorders, Pain, Drug Therapy, Adverse Effects, Drug Therapy, Other, Infectious Diseases Clinical Crossroads Source Type: journals

Immune therapy for age-related diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human aging is reaching epidemic proportions as life expectancy increases and birth rate decreases. These demographic trends have led to a sharp increase in the diseases of aging, and an understanding of immune senescence promises to limit the development and progression of these diseases. In this review, we discuss three of the most important diseases of aging: shingles, Alzheimer's disease and atherosclerotic cardiovascular disease. All of these diseases have significant immunological components in either their etiology and/or progression, suggesting that appropriate immune intervention could be used in their prevent...
Source: Trends in Immunology - June 18, 2009 Category: Allergy & Immunology Authors: Weksler ME, Pawelec G, Franceschi C Tags: Trends Immunol Source Type: journals

Does varicella-zoster virus infection of the peripheral ganglia cause Chronic Fatigue Syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article posits that infection of the peripheral ganglia causes at least some cases of Chronic Fatigue Syndrome (CFS), with a neurotropic herpesvirus, particularly varicella-zoster virus (VZV), as the most likely cause of the infection. Virtually all CFS symptoms could be produced by an infection of the peripheral ganglia, with infection of the autonomic ganglia causing fatigue, postural hypotension, and sleep disturbances, and infection of the sensory ganglia causing sensory symptoms such as chronic pain. Furthermore, infections of the peripheral ganglia are known to cause long-term nerve dysfunction, which would help...
Source: Medical Hypotheses - June 10, 2009 Category: Biomedical Science Authors: Judith S. Shapiro Source Type: journals

Shingles vaccine (JANUARY 2009)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cleveland Clinic Journal of Medicine)
Source: Cleveland Clinic Journal of Medicine - June 1, 2009 Category: Journals (General) Authors: SHAHEEN, L. Tags: Letter to the Editor Source Type: journals

Zoster Vaccine, Severe Skin Diseases Don't MixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO — Immunization with the live attenuated herpes zoster vaccine (Zostavax) probably isn't worth the potential risks in patients with psoriasis or other chronic inflammatory skin diseases, Dr. Alice Gottlieb said. (Source: Skin and Allergy News)
Source: Skin and Allergy News - June 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: Infectious Diseases Source Type: journals

Shingles and the vaccine to prevent it.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19478611 [PubMed - indexed for MEDLINE] (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - May 31, 2009 Category: Nursing Authors: Wielawski IM Tags: Am J Nurs Source Type: journals

Coalition of advocates to vaccinate of Western European citizens aged 60 years and older.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The high burden of infectious diseases in adults aged 60 years and older is disproportionate, considering that many of these diseases are vaccine-preventable. Based on careful analysis of the reasons for vaccination barriers/failures in the European population, the two European geriatric and gerontological societies (the European Union Geriatric Medicine Society [EUGMS] and the International Association of Gerontology and Geriatrics - European Region [IAGG-ER]) propose careful adaptation of current vaccine guidelines to promote preventive aspects, concerning both life threatening-diseases (influenza, pneumococcal pneum...
Source: Aging Clinical and Experimental Research - May 31, 2009 Category: Geriatrics Authors: Michel JP, Chidiac C, Grubeck-Loebenstein B, Johnson RW, Lambert PH, Maggi S, Moulias R, Nicholson K, Werner H Tags: Aging Clin Exp Res Source Type: journals

Educational vaccine tools: the French initiative.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepared a set of educational material about vaccination for older subjects. The tool has been designed to be used by medical teachers to help them teach this topic to other physicians, nursing staff and students. The group first defined teaching objectives and reviewed the scientific literature on the efficacy a...
Source: Aging Clinical and Experimental Research - May 31, 2009 Category: Geriatrics Authors: Belmin J, Bourée P, Camus D, Guiso N, Jeandel C, Trivalle C, Veyssier P Tags: Aging Clin Exp Res Source Type: journals

Herpes Zoster and Postherpetic Neuralgia: a review of the effects of vaccination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes zoster (HZ) results from reactivation of varicella zoster virus which has been persistent but clinically latent in dorsal root and cranial nerve ganglia since primary infection, usually as a child, with varicella (chicken pox). HZ affects 20-30% of individuals during their lifetime and up to 50% of those >/=80 years old. Although serious life- or sightthreatening complications occur rarely, postherpetic neuralgia (PHN) is the most common complication. Both HZ and PHN are most common in the elderly. Declining cell-mediated immunity resulting from immune senescence appears to be the cause. Incidence of HZ is al...
Source: Aging Clinical and Experimental Research - May 31, 2009 Category: Geriatrics Authors: Johnson RW Tags: Aging Clin Exp Res Source Type: journals

Overview of vaccination policies for the elderly in Western European countries.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Age-related changes in the immune system are associated with increased susceptibility to infections, greater disease severity and poorer outcomes in the elderly compared with young adults. Both influenza and pneumonia are important causes of morbidity and mortality in the elderly, and herpes zoster also represents an important disease burden in this population. Vaccinations against influenza and Streptococcus pneumoniae (pneumococcus) have been shown to reduce the incidence of influenza and invasive pneumococcal disease, respectively, in the elderly. In addition, as is the case with diphtheria/tetanus and herpes zoster...
Source: Aging Clinical and Experimental Research - May 31, 2009 Category: Geriatrics Authors: Samson SI, Mégard Y Tags: Aging Clin Exp Res Source Type: journals

Zostavax and Psoriasis Do Not MixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO — Immunization with the live attenuated herpes zoster vaccine (Zostavax) probably isn't worth the potential risks in patients with psoriasis or other chronic inflammatory skin diseases, Dr. Alice Gottlieb asserted at the annual meeting of the American Academy of Dermatology. (Source: Family Practice News)
Source: Family Practice News - May 1, 2009 Category: Primary Care Authors: BRUCE JANCIN Tags: Infectious Diseases Source Type: news

Adult Vaccine-Preventable Diseases CrosstalkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Learn about the latest data on the use and effectiveness of vaccinations for 5 common vaccine-preventable diseases in adults: influenza, pneumococcal disease, pertussis, herpes zoster, and human papillomavirus infection. (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - April 2, 2009 Category: Allergy & Immunology Tags: Infectious Diseases Source Type: info

Varicella zoster vaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the past, the varicella zoster virus affected virtually the entire population and had substantial morbidity and mortality associated with both primary varicella and herpes zoster reactivation. Since the varicella vaccine was first approved in 1995, there has been a significant decline in incidence, morbidity, and mortality caused by primary varicella. Breakthrough disease with the one-dose vaccine schedule led to the recommendation in 2006 that children receive a two-dose vaccine series. Older adults have also benefited from the development of the zoster vaccine. In 2006, the Food and Drug Administration approved the zo...
Source: Dermatologic Therapy - March 25, 2009 Category: Dermatology Authors: Rosella Creed, Anita Satyaprakash, Parisa Ravanfar Tags: vaccines in Dermatology Source Type: journals

Vaccines under study: non-HIV vaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article focuses on vaccines that have yet to be approved for licensure. (Source: Dermatologic Therapy)
Source: Dermatologic Therapy - March 25, 2009 Category: Dermatology Authors: Kelly Conner, Alice Wuu, Victoria Maldonado, Brenda L. Bartlett, Stephen K. Tyring Tags: vaccines in Dermatology Source Type: journals

[NEWS] Shingles vaccination is likely to be cost effective at age 65 or 70Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ)
Source: BMJ - March 6, 2009 Category: Journals (General) Authors: Dobson, R. Tags: Infectious diseases, Health policy, Epidemiologic studies, General practice / family medicine, Immunology (including allergy), Neuromuscular disease, Pain (neurology), Peripheral nerve disease, Health economics, Health service research NEWS Source Type: journals

A Comparison of the Immunogenicity and Safety of ZOSTAVAX(R) in Adults 50 to 59 Years Old and Adults >=60 Years Old.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: After a dose of ZOSTAVAX(R), GMFR of VZV Ab response in subjects 50 to 59 years old was noninferior to that in subjects >/=60 years old. VZV Ab response was acceptable in both age groups. ZOSTAVAX(R) was generally well tolerated in both age groups. PMID: 19261769 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - March 4, 2009 Category: Allergy & Immunology Authors: Sutradhar SC, Wang WW, Schlienger K, Stek JE, Xu J, Chan IS, Silber JL Tags: Clin vaccine Immunol Source Type: journals

Shingles vaccine ((JANUARY 2009)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cleveland Clinic Journal of Medicine)
Source: Cleveland Clinic Journal of Medicine - March 2, 2009 Category: Journals (General) Authors: HIRSCH, R. Tags: Letters to the Editor Source Type: journals

Herpes zoster (shingles) and postherpetic neuralgia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes zoster (HZ), commonly called shingles, is a distinctive syndrome caused by reactivation of varicella zoster virus (VZV). This reactivation occurs when immunity to VZV declines because of aging or immunosuppression. Herpes zoster can occur at any age but most commonly affects the elderly population. Postherpetic neuralgia (PHN), defined as pain persisting more than 3 months after the rash has healed, is a debilitating and difficult to manage consequence of HZ. The diagnosis of HZ is usually made clinically on the basis of the characteristic appearance of the rash. Early recognition and treatment can reduce acute ...
Source: Mayo Clinic Proceedings - March 1, 2009 Category: Internal Medicine Authors: Sampathkumar P, Drage LA, Martin DP Tags: Mayo Clin Proc Source Type: journals

Childhood Chicken Pox Can Lead To Shingles Later In LifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
You may recall as a child catching the itchy red rash, chicken pox. The unsightly infection was caused by the varicella zoster virus and was responsible for nearly 4 million cases each year, until a vaccine introduced in 1995 reduced that number by 83 percent. Varicella zoster can lie dormant in the body for decades, and if activated can lead to herpes zoster, more commonly referred to as shingles, according to a new study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 24, 2009 Category: Science Source Type: news

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day.Treatment with monoclonal anti–TNF- antibodies for RA may be associated with increased risk of herpes zoster http://is.gd/jTdyTNF-alpha blockers doubled the risk of herpes zoster among rheumatoid arthritis sufferers in a 5,040-patient study http://is.gd/jThWMonoclonal anti–TNF- antibodies Humira, Kineret, and Remicade each increased shingles risk by 80%. Enbrel did not. http://is.gd/jThWJAMA: Half of adult cancer survivo...
Source: Clinical Cases and Images - February 18, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

Shingles vaccine comes step nearerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction of a vaccination programme against shingles in older people would be cost-effective, concludes a study to be submitted to a Government advisory committee. (Source: Pulse)
Source: Pulse - January 30, 2009 Category: Primary Care Tags: Picture stories Source Type: news

Shingles vaccine comes a step nearerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study prepared for a Government advisory committee finds the introduction of a vaccination programme against shingles in older people is likely to be cost-effective. (Source: Pulse Today Clinical Updates)
Source: Pulse Today Clinical Updates - January 30, 2009 Category: Primary Care Tags: Picture stories Source Type: info

Estimating the cost-effectiveness of vaccination against herpes zoster in England and Wales.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study uses a Markov cohort model to estimate whether routine vaccination of the elderly (60+) would be cost-effective, when compared with other uses of health care resources. Vaccine efficacy parameters are estimated by fitting a model to clinical trial data. Estimates of QALY losses due to acute HZ and post-herpetic neuralgia were derived by fitting models to data on the duration of pain by severity and the QoL detriment associated with different severity categories, as reported in a number of different studies. Other parameters (such as cost and incidence estimates) were based on the literature, or UK data sources. ...
Source: Vaccine - January 7, 2009 Category: Allergy & Immunology Authors: Van Hoek AJ, Gay N, Melegaro A, Opstelten W, Edmunds WJ Tags: vaccine Source Type: journals

Q: Who should receive the shingles vaccine?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The answer: Nearly everyone who is age 60 and older, immunocompetent, and without contraindications to it. (Source: Cleveland Clinic Journal of Medicine)
Source: Cleveland Clinic Journal of Medicine - January 2, 2009 Category: Journals (General) Authors: SINGH, A., ENGLUND, K. Tags: 1-Minute Consult Source Type: journals

New Viral Prophylactic Vaccines: Dermatology Perspective and UpdateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new vaccines for human papillomavirus (HPV) and herpes zoster (HZ) vaccines should impact dermatological diseases and the healthcare and economic burdens associated with these two viruses. AccessMedicine from McGraw-Hill (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - December 30, 2008 Category: Infectious Diseases Tags: Internal Medicine Source Type: info

Herpes zoster vaccination among adults aged 60 years or older in the United States, 2007: Uptake of the first new vaccine to target seniors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Soon after its availability in the United States, coverage among adults recommended to receive the HZ vaccine was low. Our data provide evidence that the lack of patient awareness and of physician recommendations were barriers to vaccine uptake. PMID: 19071175 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 8, 2008 Category: Allergy & Immunology Authors: Lu PJ, Euler GL, Jumaan AO, Harpaz R Tags: vaccine Source Type: journals

Recovery of varicella-zoster virus-specific T cell immunity after T cell-depleted allogeneic transplantation requires symptomatic virus reactivation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reactivated varicella-zoster virus (VZV) infection causes herpes zoster and commonly occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because VZV-specific T cell immunity is essential to prevent virus reactivation, we developed an interferon-gamma enzyme-linked immunosorbent spot (ELISPOT) assay for the sensitive detection of VZV-reactive T cells at the single-cell level ex vivo. We used this assay to monitor the frequency of VZV-reactive T cells in 17 seropositive patients during the first year after T cell-depleted allo-HSCT. The patients did not receive anti-herpesvirus prophylaxis after ...
Source: Biology of Blood and Marrow Transplantation - December 1, 2008 Category: Hematology Authors: Distler E, Schnürer E, Wagner E, von Auer C, Plachter B, Wehler D, Huber C, Kolbe K, Meyer RG, Herr W Tags: Biol Blood Marrow Transplant Source Type: journals

Genome-wide reduction in transcriptomal profiles of varicella-zoster virus vaccine strains compared with Parental Oka strain using long oligonucleotide microarraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Varicella-Zoster virus (VZV) causes varicella as a primary infection following which it becomes latent in human ganglia and then reactivates to cause herpes zoster. VZV vaccines are used to prevent primary infection with varicella, and also to reduce the incidence of viral reactivation causing herpes zoster and post-herpetic neuralgia. To gain further insights into the molecular basis of their attenuated virulence, we used long oligonucleotide microarrays to determine the lytic transcriptomal profiles of two vaccine VZV strains (Merck and GSK) compared with the Oka parental (P-Oka) strain. There was...
Source: Virus Genes - November 27, 2008 Category: Genetics & Stem Cells Tags: Virus Genes Source Type: journals

Should a Patient Exposed to Shingles Receive the Zoster Vaccine?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A man whose wife has shingles requests an immunization to protect him from the disease. Medscape Pharmacists (Source: Medscape PublicHealth Headlines)
Source: Medscape PublicHealth Headlines - November 26, 2008 Category: Primary Care Tags: Pharmacist Source Type: info

Herpes Zoster and Meningitis Resulting From Reactivation of Varicella Vaccine Virus in an Immunocompetent Child.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present one of the first cases of aseptic meningitis after herpes zoster caused by reactivation of vaccine-type varicella-zoster virus in an immunocompetent child. We also highlight the increasing role of both wild-type and vaccine strains of varicella-zoster virus as a cause of viral meningoencephalitis and the use of appropriate laboratory tools to rapidly and accurately identify the virus in order to provide prompt patient care and management. PMID: 19028409 [PubMed - as supplied by publisher] (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - November 22, 2008 Category: Emergency Medicine Authors: Iyer S, Mittal MK, Hodinka RL Tags: Ann Emerg Med Source Type: journals