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GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data ShowsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Immune System / vaccines Source Type: news

GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data ShowsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / vaccines Source Type: news

[Newsdesk] Childhood vaccination and progress towards MDG4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Agencies and individuals worldwide are continuing their efforts to vaccinate the world's children and their achievements are highlighted by State of the World's Vaccines and Immunization, a major report published recently by WHO, UNICEF, and The World Bank. “We have good news…”, announced Daisy Mafubelu, Assistant Director General of Family and Community Health at WHO (Geneva, Switzerland). “The number of children being vaccinated is now at an all time high—and we have the numbers to prove this.” In 2008, 106 million children received routine vaccinations for childhood killer infectious diseases including measl...
Source: The Lancet Infectious Diseases - November 16, 2009 Category: Infectious Diseases Authors: Kathryn Senior Tags: Newsdesk Source Type: journals

KINRIX (Diphtheria And Tetanus Toxoids And Acellular Pertussis Adsorbed And Inactivated Poliovirus Vaccine) Injection, Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 13, 2009 Category: Drugs & Pharmacology Source Type: organizations

BOOSTRIX (Tetanus Toxoid, Reduced Diphtheria Toxoid And Acellular Pertussis Vaccine, Adsorbed) Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 13, 2009 Category: Drugs & Pharmacology Source Type: organizations

PEDIARIX (Diphtheria And Tetanus Toxoids And Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) And Inactivated Poliovirus Vaccine Combined) Injection, Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 12, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 12, 2009 Category: Drugs & Pharmacology Source Type: organizations

Pattern of functional antibody activity against Haemophilus influenzae type b (Hib) in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We evaluated the functional activity of Haemophilus influenzae B (Hib) antibodies elicited in a group of infants immunized with the diphtheria-tetanus-pertussis vaccine combined with an Hib vaccine produced totally in Brazil after technological transfer of Hib vaccine production from Glaxo SmithKline, Belgium. Blood samples from immunized infants (N = 985) were collected for the determination of Hib antibodies. Total Ig and IgM and IgG subclasses of antibodies against polyribosyl ribitol phosphate (PRP) were analyzed by ELISA. Almost all vaccinees (97.56%, 961/985) developed a strong anti-PRP IgG antibody response (>...
Source: Braz J Med Biol Res - November 6, 2009 Category: Research Authors: Matos DC, Silva AM, Neves PC, Martins RM, Homma A, Marcovistz R Tags: Braz J Med Biol Res Source Type: journals

Whooping Cough Immunity Lasts Longer Than Previously ThoughtEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immunity to whooping cough lasts at least 30 years on average, much longer than previously thought, according to a new study by researchers based at the University of Michigan and the University of New Mexico. Details are published October 30 in the open-access journal PLoS Pathogens. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 5, 2009 Category: Consumer Health News Tags: Immune System / vaccines Source Type: news

Whooping Cough Immunity Lasts Longer Than Previously ThoughtEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immunity to whooping cough lasts at least 30 years on average, much longer than previously thought, according to a new study by researchers based at the University of Michigan and the University of New Mexico. Details are published October 30 in the open-access journal PLoS Pathogens. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 5, 2009 Category: Allergy & Immunology Tags: Immune System / vaccines Source Type: news

INFANRIX (Diphtheria And Tetanus Toxoids And Acellular Pertussis Vaccine Adsorbed) Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 3, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 3, 2009 Category: Drugs & Pharmacology Source Type: organizations

Vaccines as a trigger for myopathies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vaccines are considered to be among the greatest medical discoveries, credited with the virtual eradication of some diseases and the consequent improved survival and quality of life of the at-risk population. With that, vaccines are among the environmental factors implicated as triggers for the development of inflammatory myopathies. The sporadic reports on vaccine-induced inflammatory myopathies include cases of hepatitis B virus, bacillus Calmette-Guérin, tetanus, influenza, smallpox, polio, diphtheria, diphtheria-pertussis-tetanus, combination of diphtheria with scarlet fever and diphtheria-pertussis-tetanus wi...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Orbach H, Tanay A Tags: Lupus Source Type: journals

Transverse myelitis and vaccines: a multi-analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transverse myelitis is a rare clinical syndrome in which an immune-mediated process causes neural injury to the spinal cord. The pathogenesis of transverse myelitis is mostly of an autoimmune nature, triggered by various environmental factors, including vaccination. Our aim here was to search for and analyze reported cases of transverse myelitis following vaccination. A systematic review of PubMed, EMBASE and DynaMed for all English-language journals published between 1970 and 2009 was preformed, utilizing the key words transverse myelitis, myelitis, vaccines, post-vaccination, vaccination and autoimmunity. We have dis...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Agmon-Levin N, Kivity S, Szyper-Kravitz M, Shoenfeld Y Tags: Lupus Source Type: journals

Daptacel (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Daptacel (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 30, 2009 Category: Drugs & Pharmacology Source Type: consumer

Pediarix (Diphtheria, Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B and Inactivated Poliovirus Vaccine) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pediarix (Diphtheria, Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B and Inactivated Poliovirus Vaccine) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 29, 2009 Category: Drugs & Pharmacology Source Type: consumer

Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Before childhood vaccination was introduced in the 1950s, pertussis or whooping cough was a major cause of infant death worldwide. Widespread vaccination of children was successful in significantly reducing morbidity and mortality. However, despite vaccination, pertussis has persisted and, in the 1990s, resurged in a number of countries with highly vaccinated populations. Indeed, pertussis has become the most prevalent vaccine-preventable disease in developed countries with estimated infection frequencies of 1%-6%. Recently vaccinated children are well protected against pertussis disease and its increase is mainly seen...
Source: Infection, Genetics and Evolution - October 29, 2009 Category: Genetics & Stem Cells Authors: Mooi FR Tags: Infect Genet Evol Source Type: journals

Development and Analytical Validation of Immunoassay for Quantifying Serum Anti-Pertussis Toxin Antibodies Resulting from Bordetella pertussis Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the IgG anti-PT ELISA assay met all assay validation parameters within the range considered most relevant for serodiagnosis. This ELISA was developed and analytically validated to be a user-friendly kit that can be used in both qualitative and quantitative formats. The technology for producing the kit is transferrable to public health laboratories. PMID: 19864485 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - October 28, 2009 Category: Allergy & Immunology Authors: Menzies SL, Kadwad V, Pawloski L, Lin TL, Baughman AL, Martin M, Tondella ML, Meade BD, Tags: Clin vaccine Immunol Source Type: journals

Teenagers Difficult To 'Capture' For Vaccinations; Rates On Rise Overall, But Still LowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
More teenagers are being vaccinated against human papillomavirus (HPV), meningococcal meningitis and pertussis (whooping cough), though the rates are still too low, according to recently released government data and a panel of experts convened by the National Foundation for Infectious Diseases (NFID). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 27, 2009 Category: Consumer Health News Tags: Cervical Cancer / HPV vaccine Source Type: news

Vaccines: Bordetella pertussis and Pertussis VaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 49, Issue 10, Page 1565-1569, 15 November 2009. Bordetella pertussis is a human‐specific pathogen that causes whooping cough. The use of pertussis whole‐cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life‐long immunity; indeed, the circulation of the bacterium has not been controlled in the adult population. Universal adult booster immunization is now possible using pertussis acellular vaccines, which target—and are thus li...
Source: Clinical Infectious Diseases Latest Issue - October 27, 2009 Category: Infectious Diseases Tags: article vaccines Source Type: journals

[Vaccination rate of premature infants at 6 and 24 months of age: A pilot study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The vaccine practices do not follow the postnatal chronological age of the premature baby according to the schedule recommended for full-term infants and vaccination is begun late. Based on the CSHPF vaccination recommendations, nearly 7 premature infants out of 10 have an incomplete immunization status for DTPCoqHib, hepatitis B, and ROR at 2 years of age. According to the pertussis coverage observed in premature infants, the new recommendations on vaccination of the newborn's care giver and family should be completed before the infant's discharge from the hospital using a new acellular vaccine for adult immun...
Source: Archives de Pediatrie - October 23, 2009 Category: Pediatrics Authors: Pinquier D, Adde-Michela C, Ploin D, Levêque C, Marret S, Tags: Arch Pediatr Source Type: journals

Government offers health workers swine flu vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Department of Health asks health professionals to protect themselves and others by having jabRelated items from OnMedicaSchools shut due to swine flu outbreakEngland to get a swine flu 'tzar' Health Secretary announcesParents of new babies should have whooping cough boosterFlu rate now higher than seasonal norm 'Don't panic' over swine flu, doc leaders urge (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 20, 2009 Category: UK Health Source Type: news

Monocyte-derived interleukin-10 depresses the Bordetella pertussis-specific IFN-{gamma} response in vaccinated infants.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antigen-specific interferon-gamma (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-gamma after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-gamma levels between individuals. We show here that the inhibition of the specific IFN-gamma response can be at least partially attributed to an IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions -1082, -819 a...
Source: Clinical and Vaccine Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Dirix V, Verscheure V, Goetghebuer T, Hainaut M, Debrie AS, Locht C, Mascart F Tags: Clin vaccine Immunol Source Type: journals

Also notedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examines whether the pain response to administration of the diphtheria, polio, and tetanus toxoids and acellular pertussis and Haemophilus influenzae type b vaccine and the pneumococcal conjugate vaccine is affected by the order in which they are given. With the validated Modified Behavioral Pain Scale, videotaped recordings of the procedure (to assess crying), and parental ratings of pain on a visual analog scale, they found that children had less pain (on all 3 measures) when the diphtheria, polio, and tetanus toxoids and acellular pertussis and diphtheria, polio, and tetanus toxoids and acellular pertussis an...
Source: The Journal of Pediatrics - October 20, 2009 Category: Pediatrics Tags: Current Best Evidence Source Type: journals

Bordetella pertussis and Pertussis VaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Bordetella pertussis is a human‐specific pathogen that causes whooping cough. The use of pertussis whole‐cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life‐long immunity; indeed, the circulation of the bacterium has not been controlled in the adult population. Universal adult booster immunization is now possible using pertussis acellular vaccines, which target—and are thus likely to c...
Source: Clinical Infectious Diseases Latest Issue - October 19, 2009 Category: Infectious Diseases Tags: article vaccines Source Type: journals

[Reflection and Reaction] Has routine immunisation in Africa become endangered?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The broad picture of immunisation in Africa is one of excellent progress and enthusiastic energy, with amazing advances having been made since the turn of the century. There has been a large drop in mortality due to measles, and about a third of countries now use a three dose regimen of diphtheria-tetanus-pertussis triple vaccine (DTP3), which provides coverage of at least 80% in all districts. However, a review of immunisation in Africa found that all is not well. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - October 18, 2009 Category: Infectious Diseases Authors: Yemane Berhane, C John Clements, Jean Michel Ndiaye, Patricia Taylor Tags: Reflection and Reaction Source Type: journals

Paracetamol affects childhood jabsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Giving paracetamol to babies following a vaccine jab may lower the effectiveness of the immunisation, according to research reported on by BBC news. The study behind this news coverage is an important and well-conducted trial in which 459 babies receiving their routine immunisations were either routinely given paracetamol in the 24 hours following their injection or were given none. Although the drug was clearly successful in reducing the risk of a fever developing, it was shown to reduce the immune response to the vaccine, suggesting that it would be less effective. Although the preventative use of paracetamol had an ef...
Source: NHS News Feed - October 16, 2009 Category: Consumer Health News Tags: Pregnancy/child Medication Source Type: news

[Comment] The yin and yang of paracetamol and paediatric immunisationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although highly effective, whole-cell pertussis vaccines are associated with high rates of injection-site reactions, fever, and less commonly febrile seizures. Two trials in the 1980s showed that rates of postimmunisation fever could be reduced through the prophylactic administration of paracetamol (acetaminophen), which led the US Advisory Committee on Immunization Practice to recommend “it is reasonable to consider administering antipyretics (such as acetaminophen) at age-appropriate doses at the time of vaccination and every 4–6 h for 48–72 h to children at higher risk for seizures than the general population”. ...
Source: LANCET - October 15, 2009 Category: Journals (General) Authors: Robert T Chen, Thomas A Clark, Scott A Halperin Tags: Comment Source Type: journals

Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Area: News Two consecutive (primary and booster) open-label RCTs have assessed the effect of prophylactic administration of paracetamol at vaccination on infant febrile reaction rates and vaccine responses. The study enrolled 459 healthy infants from ten centres in the Czech Republic who were randomised to receive three prophylactic paracetamol doses every 6 to 8 hours in the first 24 hours (n=226) or no prophylactic paracetamol (n=233) after each vaccination. [Vaccines= ten-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) co-administered wi...
Source: NeLM - Immunology and vaccination - October 15, 2009 Category: Allergy & Immunology Source Type: organizations

Physical interventions and injection techniques for reducing injection pain during routine childhood immunizations: systematic review of randomized controlled trials and quasi-randomized controlled trials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Pain during immunization can be decreased by: (1) injecting the least painful formulation of a vaccine; (2) having the child sit up (or holding an infant); (3) stroking the skin or applying pressure close to the injection site before and during injection; (4) injecting the least painful vaccine first when 2 vaccines are being administered sequentially during a single office visit; and (5) performing a rapid intramuscular injection without aspiration. PMID: 19781436 [PubMed - in process] (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - October 14, 2009 Category: Drugs & Pharmacology Authors: Taddio A, Ilersich AL, Ipp M, Kikuta A, Shah V, Tags: Clin Ther Source Type: journals

Historical Data Shows Vaccines are Not what Saved UsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) With all of the hype surrounding the H1N1 swine flu virus lately, everyone is very concerned with the safety and effectiveness of vaccines, and rightly so. This is a very important question that we must all ask ourselves and find out what the truth is. As the debate rages on an even more important question has rarely been asked. Do vaccines even protect you from the viruses and illnesses that they claim to?If you only get your news and information from mainstream news and educational sources, then the question about whether vaccines are effective is never even raised. This lack of discussion give the percepti...
Source: NaturalNews.com - October 9, 2009 Category: Consumer Health Advice Source Type: news

Keeping Vulnerable Children Safe from Pertussis: Preventing Nosocomial Pertussis Transmission in the Neonatal Intensive Care Unit • Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The provision of booster vaccine to healthcare workers in the neonatal intensive care unit substantially reduces the risk of hospital‐centered pertussis outbreaks in a manner that enhances the health of hospitalized children. A formal health economic analysis of this finding is currently under way. Policies to protect patient safety in pediatric facilities should include compliance with the United States Advisory Committee on Immunization Practices, which recommends provision of pertussis booster vaccination to healthcare workers. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - October 7, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals

Diphtheria tetanus and pertussis vaccine: Recurrent hypotonic-hyporesponsive episodes in an infant: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Long-term presence of memory B-cells specific for different vaccine components.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we describe the identification of antigen-specific memory B-cells in peripheral blood of persons born between 1940 and 2004 in The Netherlands. Polyclonal stimulation of either PBMCs or purified B-cells induced proliferation and differentiation of B-cells of the memory phenotype (CD19(+)/CD27(+)) into antibody secreting cells (ASC). Memory B-cells against components of bacterial vaccines (Bordetella pertussis and tetanus) as well as viral vaccines (measles and influenza) were thus identified, even in persons with low serum antibody titers. Enrichment of B-cells increased the sensitivity of memory B-cell detec...
Source: Vaccine - September 28, 2009 Category: Allergy & Immunology Authors: Buisman AM, de Rond CG, Oztürk K, Ten Hulscher HI, van Binnendijk RS Tags: vaccine Source Type: journals

Keeping Vulnerable Children Safe from Pertussis: Preventing Nosocomial Pertussis Transmission in the Neonatal Intensive Care UnitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The provision of booster vaccine to healthcare workers in the neonatal intensive care unit substantially reduces the risk of hospital‐centered pertussis outbreaks in a manner that enhances the health of hospitalized children. A formal health economic analysis of this finding is currently under way. Policies to protect patient safety in pediatric facilities should include compliance with the United States Advisory Committee on Immunization Practices, which recommends provision of pertussis booster vaccination to healthcare workers. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - September 28, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals

AAFP Expands Pertussis Vaccination Awareness CampaignEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Almost three-quarters of U.S. adults think they are up-to-date on their immunizations, says a recent AAFP survey. According to CDC statistics, however, only 2 percent of adults received the tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, or Tdap, from 2005 through 2007. (Source: AAFP Health of the Public)
Source: AAFP Health of the Public - September 25, 2009 Category: Primary Care Source Type: news

Boosting Vaccines: The Power of Adjuvants (preview)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The thought of birth defects caused by rubella, rows of iron lungs housing children crippled by polio, or the horrific sound of a baby struggling with whooping cough can still evoke dread among people who have seen firsthand the damage inflicted by these and other vaccine-preventable diseases. Fortunately, those scourges are virtually unknown to modern generations that have had access to vaccines all their lives.For more than 200 years vaccines have proved to be one of the most successful, lifesaving and economical methods of preventing infectious disease, second only to the sanitization of water. Vaccines have spared mill...
Source: Scientific American - Official RSS Feed - September 23, 2009 Category: Science Tags: Biology,Chemistry,Health,Technology,What ' s Next,Science in Service Source Type: journals

Construction of an unmarked recombinant BCG expressing a pertussis antigen by auxotrophic complementation: Protection against Bordetella pertussis challenge in neonates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mycobacterium bovis BCG has long been investigated as a candidate for heterologous antigen presentation. We have previously described an rBCG-Pertussis that confers protection against challenge with Bordetella pertussis in neonate and adult mice. In order to obtain stable expression in vivo, we constructed an unmarked BCG lysine auxotrophic and a complementation vector containing the lysine and the genetically detoxified S1 pertussis toxin genes, both under control of the same promoter. Complemented BCG-Deltalysine growth and expression of the pertussis antigen were stable, without the use of an antibiotic marker. Our ...
Source: Vaccine - September 22, 2009 Category: Allergy & Immunology Authors: Nascimento IP, Dias WO, Quintilio W, Hsu T, Jacobs WR, Leite LC Tags: vaccine Source Type: journals

Cervarix (human papillomavirus vaccine) - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes New information has been included in section 4.5 (interactions) which is as follows: Use with other vaccines Cervarix may be administered concomitantly with a combined booster vaccine containing diphtheria (d), tetanus (T) and pertussis [acellular] (pa) with or without inactivated poliomyelitis (IPV), (dTpa, dTpa-IPV vaccines), with no clinically relevant interference with antibody response to any of the components of either vaccine. The sequential administration of combined dTpa-IPV followed by Cervarix one month later tended to e...
Source: NeLM - Immunology and vaccination - September 19, 2009 Category: Allergy & Immunology Source Type: organizations

National, state, and local area vaccination coverage among adolescents aged 13-17 years--United States, 2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report summarizes results from the 2008 NIS-Teen and, for the first time, includes estimates for each of the 50 states and selected local areas. Nationally, vaccination coverage for the three most recently recommended adolescent vaccinations and one childhood vaccination increased from 2007 to 2008: MCV4 (from 32.4% to 41.8%), Tdap (from 30.4% to 40.8%), >/=1 dose of HPV4 (from 25.1% to 37.2%), and >/=2 doses of VAR among those without disease history (from 18.8% to 34.1%). However, substantial variability in vaccination coverage was observed in 2008 among state and local areas and by race/ethnicity and poverty ...
Source: MMWR Morb Mortal Wkl... - September 17, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals

Vaccine Adherence in AdolescentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article outlines barriers to vaccine compliance among adolescents and discusses strategies to increase vaccine uptake. (Source: Clinical Pediatrics)
Source: Clinical Pediatrics - September 16, 2009 Category: Pediatrics Authors: Lehmann, C., Benson, P. A. S. Tags: Articles Source Type: journals

Risk of immune hemolytic anemia in children following immunization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the risk of IHA in the 42 days following vaccination exposure using a self-controlled case series study design. In our population-based cohort of nearly 4.5 million children in the Vaccine Safety Datalink, we identified 55 confirmed cases of new-onset IHA from 1991 through 2000. We found no association between IHA and diphtheria-pertussis-tetanus vaccination (incidence rate ratio (IRR)=0.65, 95% CI: 0.19-2.24), hepatitis B vaccination (IRR=1.73, 95% CI: 0.59-5.01), or any vaccination (IRR=1.04, 95% CI: 0.46-2.32). PMID: 19766577 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 16, 2009 Category: Allergy & Immunology Authors: Naleway AL, Belongia EA, Donahue JG, Kieke BA, Glanz JM, Tags: vaccine Source Type: journals

Modified intra-cerebral challenge assay for acellular pertussis vaccines: Comparisons among whole cell and acellular vaccines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study thus suggests that an aP vaccine standard would improve inter-laboratory agreement. These data do not show significant dissimilarity in dose-response lines between JNIH-3 and the various vaccine products included, irrespective of the differences in aP components. Available data indicate that JNIH-3 is sufficiently stable to serve as an International Standard. On the basis of these results and with the agreement of the participants, it was proposed that JNIH-3 should be established as an International Standard for acellular pertussis vaccine for use in the modified intra-cerebral challenge assay and other protect...
Source: Vaccine - September 14, 2009 Category: Allergy & Immunology Authors: Gaines-Das R, Horiuchi Y, Zhang SM, Newland P, Kim Y, Corbel M, Xing D Tags: vaccine Source Type: journals

KINRIX (Diphtheria And Tetanus Toxoids And Acellular Pertussis Adsorbed And Inactivated Poliovirus Vaccine) Injection, Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 14, 2009 Category: Drugs & Pharmacology Source Type: organizations

Medical and Nursing Students with Suboptimal Protective Immunity against Vaccine‐Preventable Diseases • Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. We have determined that there is a certain proportion of healthcare students who are susceptible to certain vaccine‐preventable diseases. The development of an appropriate vaccination strategy is required to decrease the risk of transmission in a hospital setting. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - September 10, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals

[Current vaccination coverage and immunization gaps of children and adolescents in Germany.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Available data show increasing vaccination coverage of children and adolescents in recent years in Germany. Vaccination coverage of children against diphtheria, tetanus, polio and haemophilus influenzae Type b is high. Vaccination gaps exist for pertussis, hepatitis B and for the second measles, mumps and rubella doses. Coverage is still insufficient to achieve effective herd immunity and measles elimination. Data from the representative German Health Interview and Examination Survey for Children and Adolescents reveal that vaccination of infants is markedly delayed compared to recommendations of the German Standing Co...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - September 9, 2009 Category: Global & Universal Authors: Reiter S, Poethko-Müller C Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: journals

Kinetics and sensitivity of ELISA IgG pertussis antitoxin after infection and vaccination with Bordetella pertussis in young childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, knowledge about anti-PT kinetics is essential for the interpretation of seroepidemiological data but hardly offers the possibility to establish valid cut-off values for anti-PT in single sample serology. An option would be to identify a grey zone between the positive and negative ends of the distribution for follow-up testing by a second serum. (Source: APMIS)
Source: APMIS - September 7, 2009 Category: Research Authors: Hans O. Hallander, Margaretha Ljungman, Jann Storsaeter, Lennart Gustafsson Source Type: journals

Pertussis Immunity and Response to Tetanus-Reduced Diphtheria-Reduced Pertussis Vaccine (Tdap) after Autologous Peripheral Blood Stem Cell TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pertussis is a highly contagious respiratory infection characterized by prolonged cough and inspiratory whoop. Despite widespread vaccination of children aged2-fold response to PT following vaccination with Tdap. These data suggest that autologous transplantation recipients are highly susceptible to pertussis and that immunization with 2.5μg of PT induces an inadequate response. Prospective trials evaluating BOOSTRIX, containing 8μg/dose of PT (approved for adults in December 2008) are warranted in this vulnerable population undergoing transplantation. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - September 7, 2009 Category: Hematology Authors: Trudy N. Small, Andrew D. Zelenetz, Ariela Noy, R. David Rice, Tanya M. Trippett, Lauren Abrey, Carol S. Portlock, Emily J. McCullagh, Jill M. Vanak, Ann Marie Mulligan, Craig H. Moskowitz Tags: Clinical Research Source Type: journals

Shantha Biotechnics Awarded Large Vaccine Contracts by United Nations AgencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sanofi Pasteur, the vaccines division of sanofi-aventis Group (EURONEXT : SAN and NYSE : SNY), announced that Shantha Biotechnics was awarded contracts by a United Nations agency for supplies of pentavalent vaccine SHAN5™ (combination vaccine of Diphtheria, Pertussis, Tetanus, Haemophilus influenza B, and Hepatitis B). The contracts, worth $340 million, cover the period 2010-2012. (Source: World Pharma News)
Source: World Pharma News - September 6, 2009 Category: Pharmaceuticals Source Type: news

Levels of childhood vaccination coverage and the impact of maternal HIV status on child vaccination status in rural KwaZulu-Natal, South Africa*Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Positive maternal HIV status independently reduces children's probability to receive child vaccinations, which likely contributes to the morbidity and mortality differential between children of HIV-positive and HIV-negative mothers. As a means of increasing vaccination coverage, policy makers should consider increasing the number of mobile clinics in this and similar communities in rural Africa. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - September 6, 2009 Category: Tropical Medicine Authors: James Ndirangu, Till Bärnighausen, Frank Tanser, Khin Tint, Marie-Louise Newell Source Type: journals

Conclusions on (cost-)effectiveness of pertussis booster vaccination strategies highly dependent on selections made in evidence review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This letter reacts on a paper recently published in this journal, reviewing the effectiveness and (cost-)effectiveness of pertussis booster vaccination strategies. We argue that a different selection of (cost-)effectiveness data could validly be made than the one presented in the review as being considered most robust. In particular, we explicitly present an alternative set of (cost-)effectiveness data. PMID: 19744583 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 6, 2009 Category: Allergy & Immunology Authors: Postma MJ, de Vries R, Roord J Tags: vaccine Source Type: journals

Pneumococcal Polysaccharide Protein D-Conjugate Vaccine (Synflorix; PHiD-CV).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
black triangle The pneumococcal polysaccharide protein D-conjugate vaccine (PHiD-CV; Synflorix) contains ten capsular polysaccharide serotypes from the bacterium Streptococcus pneumoniae, eight of which are conjugated to a nonlipidated cell-surface liporotein (protein D) of non-typeable Haemophilus influenzae (NTHi) and two of which are conjugated to either tetanus or diphtheria toxoid. black triangle In a three-dose primary vaccination schedule in infants aged <6 months, PHiD-CV elicited high immune responses against all pneumococcal serotypes contained in the vaccine and was noninferior to an approved 7-valent pne...
Source: Paediatric Drugs - September 4, 2009 Category: Pediatrics Authors: Croxtall JD, Keating GM Tags: Paediatr Drugs Source Type: journals