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Pitfalls in diagnostic hematopathology - Part II.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The overlapping features of malignant lymphomas create a diagnostic "grey zone" , and lead to the invention of "grey zone lymphomas". There are several major grey zone lymphomas: 1) Lymphomas with overlapping features of Hodgkin lymphoma and large B-cell lymphoma; 2) Lymphomas with overlapping features of Burkitt lymphoma and diffuse large B-cell lymphoma; 3) Lymphomas with overlapping features of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte rich large B-cell lymphoma; 4) Lymphomas with overlapping features of Hodgkin lymphoma, anaplastic large cell lymphoma (ALCL) and peripheral T-cell lymphom...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhao XF Tags: Int J Clin Exp Pathol Source Type: journals

Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
STATs are constitutively activated in several malignancies. In primary mediastinal large B-cell lymphoma and Hodgkin lymphoma (HL), inactivating mutations in SOCS1, an inhibitor of JAK/STAT signaling, contribute to deregulated STAT activity. Based on indications that the SOCS1 mutations are caused by the B cell–specific somatic hypermutation (SHM) process, we analyzed B-cell non-HL and normal B cells for mutations in SOCS1. One-fourth of diffuse large B-cell lymphoma and follicular lymphomas carried SOCS1 mutations, which were preferentially targeted to SHM hotspot motifs and frequently obviously inactivating. Rare m...
Source: Blood - November 12, 2009 Category: Hematology Authors: Mottok, A., Renne, C., Seifert, M., Oppermann, E., Bechstein, W., Hansmann, M.-L., Kuppers, R., Brauninger, A. Tags: Lymphoid Neoplasia, Brief Reports Source Type: journals

A rare case of primary pancreatic Burkitt lymphoma in a young Indian male. Case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Early diagnosis of this aggressive tumor and prompt induction of chemotherapy dramatically improved the patient's condition and avoided unnecessary surgical intervention. PMID: 19890195 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Nistala SS, Sawalakhe NR, Thiruvengadam NR, Rathi PM Tags: JOP Source Type: journals

An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: results from the Children's Oncology Group study CCG-5961Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Burkitt lymphoma (BL), an aggressive B-cell malignancy, is often curable with short intensive treatment regiments. Nearly all BLs contain rearrangements of the MYC/8q24 region; however, recent cytogenetic studies suggest that certain secondary chromosomal aberrations in BL correlate with an adverse prognosis. In this multi-centre study, the frequency and impact on clinical outcome of del(13q) and +7 in addition to MYC rearrangements as detected by fluorescence in situ hybridization (FISH) in children and adolescents with intermediate and high-risk BL registered on Children's Cancer Group study CCG-5961 were investigated. A...
Source: British Journal of Haematology - November 6, 2009 Category: Hematology Authors: Marilu Nelson, Sherrie L. Perkins, Bhavana J. Dave, Peter F. Coccia, Julia A. Bridge, Elizabeth R. Lyden, Nyla A. Heerema, Mark A. Lones, Lauren Harrison, Mitchell S. Cairo, Warren G. Sanger Source Type: journals

Expression of the Brain Transcription Factor OTX1 Occurs in a Subset of Normal Germinal-Center B Cells and in Aggressive Non-Hodgkin Lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study identifies OTX1 as a molecular marker for high-grade GC-derived NHL and suggests an involvement of this transcription factor in B-cell lymphomagenesis. Furthermore, OTX1 expression in a subset of normal GC B cells carrying plasma cell markers suggests its possible contribution to terminal B-cell differentiation. PMID: 19893048 [PubMed - as supplied by publisher] (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - November 5, 2009 Category: Pathology Authors: Omodei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, Frigeri F, Mancuso P, De Chiara A, Pinto A, Casola S, Simeone A Tags: Am J Pathol Source Type: journals

Caspase-8-mediated cleavage of Bid and Protein Phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we provide new insights into this signal transduction pathway. First, we demonstrate that VT-1-induced apoptosis requires degradation of the caspase-8 inhibitory molecule c-FLIP(L) and that this degradation occurs through the ubiquitin-proteasome pathway. Furthermore, we show that mitochondrial activation is mainly due to i) cleavage and activation of the pro-apoptotic Bcl-2 family member Bid by caspase-8 and ii) Bax relocalization to mitochondrial membranes which lead to cytochrome c release. However, tBid is not involved in Bax relocalization, and relocalization is most likely controlled by the extent of ...
Source: Cellular Signalling - November 3, 2009 Category: Cytology Authors: Garibal J, Hollville E, Renouf B, Tétaud C, Wiels J Tags: Cell Signal Source Type: journals

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia. PMID: 19880779 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Dictor M, Ek S, Sundberg M, Warenholt J, György C, Sernbo S, Gustavsson E, Abu-Alsoud W, Wadström T, Borrebaeck C Tags: Haematologica Source Type: journals

SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma. PMID: 19880778 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Mozos A, Royo C, Hartmann E, De Jong D, Baró C, Valera A, Fu K, Weisenburger DD, Delabie J, Chuang SS, Jaffe ES, Ruiz-Marcellan C, Dave S, Rimsza L, Braziel R, Gascoyne RD, Solé F, López-Guillermo A, Colomer D, Staudt LM, Rosenwald A, Ott G Tags: Haematologica Source Type: journals

Treatment-Related Burkitt's Lymphoma: Literature Review and Case Report of Successful Treatment with Rituximab Monotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of an elderly patient with radiotherapy-related BL. A 71-year-old Japanese man, who had a past history of oropharyngeal cancer treated with local irradiation 15 years ago, presented with a left mandibular mass in December 2004. A partial mandibulectomy disclosed pathological features consistent with BL. Although the patient was initially treated with intensive chemotherapy, the development of complications precluded further anticancer drug treatment. Rituximab was administered once weekly for 5 consecutive weeks, with resolution of the mandibular mass. He remained in remission without further lymphoma...
Source: Acta Haematologica - October 29, 2009 Category: Hematology Authors: Nagasaki A, Yamanoha A, Okudaira T, Miyagi T, Takasu N Tags: Acta Haematol Source Type: journals

Treatment-Related Burkitt's Lymphoma: Literature Review and Case Report of Successful Treatment with Rituximab MonotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acta Haematol 2009;122:211-215 (DOI:10.1159/000253028) (Source: Karger Publishers)
Source: Karger Publishers - October 28, 2009 Category: Cancer & Oncology Source Type: journals

Speckled-like Pattern in the Germinal Center (SLIP-GC), a Nuclear GTPase Expressed in Activation-induced Deaminase-expressing Lymphomas and Germinal Center B Cells [Dna: Replication, Repair, Recombination, and Chromosome Dynamics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We identified a novel GTPase, SLIP-GC, with expression limited to a few tissues, in particular germinal center B cells. It lacks homology to any known proteins, indicating that it may belong to a novel family of GTPases. SLIP-GC is expressed in germinal center B cells and in lymphomas derived from germinal center B cells such as large diffuse B cell lymphomas. In cell lines, SLIP-GC is expressed in lymphomas that express activation-induced deaminase (AID) and that likely undergo somatic hypermutation. SLIP-GC is a nuclear protein, and it localizes to replication factories. Reduction of SLIP-GC levels in the Burkitt lymphom...
Source: Journal of Biological Chemistry - October 23, 2009 Category: Chemistry Authors: Richter, K., Brar, S., Ray, M., Pisitkun, P., Bolland, S., Verkoczy, L., Diaz, M. Tags: Dna: Replication, Repair, Recombination, and Chromosome Dynamics Source Type: journals

MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Approximately 5% to 10% of diffuse large B-cell lymphomas (DLBCLs) harbor an MYC oncogene rearrangement (MYC+). The prognostic significance of MYC+ DLBCL was determined in an unselected population of patients with newly diagnosed DLBCL treated with rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP). Using a Vysis break-apart fluorescence in situ hybridization probe, 12 of 135 (8.8%) cases of MYC+ DLBCL were identified that had no defining high-risk features. MYC+ DLBCL was associated with an inferior 5-year progression-free survival (66% vs 31%, P = .006) and over...
Source: Blood - October 22, 2009 Category: Hematology Authors: Savage, K. J., Johnson, N. A., Ben-Neriah, S., Connors, J. M., Sehn, L. H., Farinha, P., Horsman, D. E., Gascoyne, R. D. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Burkitt Lymphoma (BL) is listed in the World Health Organization (WHO) classification of lymphoid tumours as an 'aggressive B-cell non-Hodgkin's lymphoma', characterized by a high degree of proliferation of the malignant cells and deregulation of the c-MYC gene. The main diagnostic challenge in BL is to distinguish it from diffuse large B-cell lymphoma (DLBCL). While in children BL and DLBCL types probably do not differ clinically, and the differential diagnosis between BL and DLBCL may theoretically appear clear-cut, in adults daily practice shows the existence of cases that have morphological features, immunophenotypic a...
Source: Hematological Oncology - October 20, 2009 Category: Hematology Authors: Cristiana Bellan, Lazzi Stefano, De Falco Giulia, Emily A Rogena, Leoncini Lorenzo Source Type: journals

Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis [Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although Epstein-Barr virus (EBV) is linked to Burkitt's lymphoma (BL), the role of the virus in lymphomagenesis is unclear. LMP2A,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 20, 2009 Category: Science Authors: Bieging, K. T., Amick, A. C., Longnecker, R. Tags: Microbiology Source Type: journals

[Child sinonasal Burkitt's lymphoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19837378 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - October 16, 2009 Category: ENT & OMF Authors: Luqui-Albisua I, Estéfano-Rodríquez J, Algaba-Guimerá J Tags: Acta Otorrinolaringol Esp Source Type: journals

Genome wide DNA-profiling of HIV-related B-cell lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Non-Hodgkin lymphomas (NHL) represent a frequent complication of human immunodeficiency virus (HIV) infection. To elucidate HIV-NHL pathogenesis, we performed a genome-wide DNA profiling based on a single nucleotide polymorphism-based microarray comparative genomic hybridization in 57 HIV-lymphomas and, for comparison, in 105 immunocompetent diffuse large B-cell lymphomas (IC-DLBCL). Genomic complexity varied across HIV-NHL subtypes. HIV-Burkitt lymphoma showed a significantly lower number of lesions than HIV-DLBCL (P = 0·032), whereas the median number of copy number changes was significantly higher in Epstein[ndash]Barr...
Source: British Journal of Haematology - October 13, 2009 Category: Hematology Authors: Daniela Capello, Marta Scandurra, Giulia Poretti, Paola M. V. Rancoita, Michael Mian, Annunziata Gloghini, Clara Deambrogi, Maurizio Martini, Davide Rossi, Timothy C. Greiner, Wing C. Chan, Maurilio Ponzoni, Santiago M. Moreno, Miguel A. Piris, Vincenzo C Source Type: journals

Temozolomide: Burkitt's lymphoma: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 12, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

[Ileocolic invagination in Burkitt lymphoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19822315 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - October 9, 2009 Category: Surgery Authors: Moreno Alarcón C, Martín Díaz L, Sánchez Valero J, Vicente Cantero M, Parrilla P Tags: Cir Esp Source Type: journals

Evaluation of ARG protein expression in mature B cell lymphomas compared to non-neoplastic reactive lymph node.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we evaluated ARG protein expression in Follicular Lymphoma (FL), Burkitt's Lymphoma (BL) and Diffused Large B Cell Lymphoma (DLBCL) in comparison with non-neoplastic lymph nodes. Semi-quantitative fluorescent ImmunoHistoChemistry was applied on 14, 7 and 4 patients with DLBCL, FL and BL respectively, adding to 4 normal and 4 reactive lymph nodes. The mean ratio of ARG/GAPDH expression was significantly different (p<0.00) between lymphomas and control samples, with DLBCL having the highest ARG expression amongst all. Over expression of ARG was seen in FL and BL, with FL expressing statistically more ARG tha...
Source: Cellular Immunology - October 8, 2009 Category: Allergy & Immunology Authors: Kabiri Z, Salehi M, Mokarian F, Mohajeri MR, Mahmoodi F, Keyhanian K, Doostan I, Ataollahi MR, Modarressi MH Tags: Cell Immunol Source Type: journals

Interferon-resistant Daudi Cell Line with a Stat2 Defect Is Resistant to Apoptosis Induced by Chemotherapeutic Agents [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interferon- (IFN) has shown promise in the treatment of various cancers. However, the development of IFN resistance is a significant drawback. Using conditions that mimic in vivo selection of IFN-resistant cells, the RST2 IFN-resistant cell line was isolated from the highly IFN-sensitive Daudi human Burkitt lymphoma cell line. The RST2 cell line was resistant to the antiviral, antiproliferative, and gene-induction actions of IFN. Although STAT2 mRNA was present, STAT2 protein expression was deficient in RST2 cells. A variant STAT2 mRNA, which resulted from alternative splicing within the intron between exon 19 and 20, was ...
Source: Journal of Biological Chemistry - October 2, 2009 Category: Chemistry Authors: Du, Z., Fan, M., Kim, J.-G., Eckerle, D., Lothstein, L., Wei, L., Pfeffer, L. M. Tags: Mechanisms Of Signal Transduction Source Type: journals

Marked therapeutic efficacy of a novel polyethylene glycol-SN38 conjugate, EZN-2208, in xenograft models of B-cell non-Hodgkin's lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Examination of the clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active metabolite of CPT-11, has not been possible to date due to poor solubility of SN38. Here we evaluated the activity of EZN-2208, a water-soluble polyethyleneglycol-SN38 conjugate, in pre-clinical models of Burkitt's non-Hodgkin's lymphoma (NHL) (Raji and Daudi), and follicular NHL (DoHH2). In vitro, the IC50 of EZN-2208 ranged from 3-24 nM, which was 30- to 45-fold lower than CPT-11 or 2.5- to 3.5-fold higher than SN38. In both an early-disease Raji model and an advanced-disease Daudi model, treatment with multiple doses of EZN-220...
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Sapra P, Kraft P, Mehlig M, Malaby J, Zhao H, Greenberger LM, Horak ID Tags: Haematologica Source Type: journals

Monoclonal Antibody Therapy with Rituximab for Acute Lymphoblastic LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article comprehensively reviews available data regarding the use of rituximab for the treatment of Burkitt-type leukemia/lymphoma and CD20-positive precursor B-cell ALL. The incorporation of rituximab into frontline chemotherapy regimens for Burkitt-type leukemia/lymphoma appears to improve outcome. Preliminary data regarding the use of rituximab in frontline therapy for CD20- positive precursor B-cell ALL suggest its use may also be beneficial, particularly for the younger subsets. (Source: Hematology/Oncology Clinics of North America)
Source: Hematology/Oncology Clinics of North America - September 30, 2009 Category: Cancer & Oncology Authors: Deborah A. Thomas, Susan O'Brien, Hagop M. Kantarjian Source Type: journals

Lymphoma in Adolescents and Young AdultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Non-Hodgkin (NHL) and Hodgkin (HL) lymphomas are represented prominently in the adolescent and young adult (AYA) population. These diseases represent 11% of total cancer diagnoses in children, 4% in those 40 years of age and older, and 13% in AYA (aged 15–39 years). Although age-adjusted incidence rates of NHL increase with age, the more aggressive lymphomas are seen more commonly in the younger population with a transition to low-grade, indolent subtypes as the population ages. Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma make up the most common subtypes in ...
Source: Seminars in Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Samantha M. Jaglowski, Erica Linden, Amanda M. Termuhlen, Joseph M. Flynn Tags: Impact of malignant Disease on Young Adults II Source Type: journals

Inhibition of KSHV infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we extended these studies to explore the possibility that manipulation of the Notch signaling by GSI would prevent the growth of the PEL tumors in vivo. We observed that the onset of tumorigenesis of KSHV infected PELs was significantly delayed in GSI treated SCID mice harboring the PEL cell lines. We also found that GSI treatment resulted in necrosis as well as apoptosis in tumors generated by the xenotransplanted KSHV positive PEL cell lines. In contrast, GSI had no effect on mice harboring BJAB cells, a KSHV negative Burkitt's lymphoma cell line where ICN levels were negligible. Our study provides further...
Source: Cancer Biology and Therapy - September 29, 2009 Category: Cancer & Oncology Authors: Lan K, Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES Tags: Cancer Biol Ther Source Type: journals

Modulation of innate immunity system by Epstein–Barr virus-encoded non-coding RNA and oncogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epstein[ndash]Barr virus (EBV)-encoded small RNAs (EBERs) are polyA[ndash], non-coding RNAs that are expressed abundantly in all forms of cells latently infected with EBV. EBERs (EBER1 and EBER2) contribute to the clonal proliferation of EBV-negative Burkitt's lymphoma (BL) cells in soft agar, tumorigenicity in SCID mice, up-regulation of the bcl-2 oncoprotein, resistance to apoptosis, and maintenance of malignant phenotypes in BL cells. EBERs induce the expression of interleukin (IL)-10 in BL cells, insulin-like growth factor 1 (IGF-I) in gastric and nasopharyngeal carcinoma cells, IL-9 in T cells, and IL-6 in lymphoblast...
Source: Cancer Science - September 29, 2009 Category: Cancer & Oncology Authors: Mrinal Samanta, Kenzo Takada Source Type: journals

Extramedullary plasmacytoma-like posttransplantation lymphoproliferative disorders: clinical and pathologic features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes the clinical, histologic, phenotypic, and genotypic findings in 4 cases of plasmacytoma-like PTLD (2 nodal, 1 adenoidal, and 1 cutaneous) and compares the findings with extramedullary involvement by plasma cell neoplasms arising in immunocompetent patients. Plasmacytoma-like PTLDs characteristically arise late after transplantation (mean, 7.0 years), show a variable association with Epstein-Barr virus (2/4 cases positive), and demonstrate histologic and phenotypic findings that overlap with immunocompetent extramedullary plasma cell neoplasms. None of the patients with plasmacytoma-like PTLD developed...
Source: American Journal of Clinical Pathology - September 21, 2009 Category: Pathology Authors: Richendollar BG, Hsi ED, Cook JR Tags: Am J Clin Pathol Source Type: journals

The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematologic malignancies, enhanced NF-B exerts prosurvival functions. Here we investigated the role of NF-B in mouse and human c-MYC–transformed lymphomas. The NF-B pathway is extinguished in murine lymphoma cells, and extrinsic stimuli typically inducing NF-B activity fail to activate this pathway. Genetic activation of the NF-B pathway induces apoptosis in these cells, whereas inhibition of NF-B by an IB superrepressor provides a selective advantage in vivo. Furthermore, in human Burkitt lymphoma cells w...
Source: Blood - September 16, 2009 Category: Hematology Authors: Klapproth, K., Sander, S., Marinkovic, D., Baumann, B., Wirth, T. Tags: Lymphoid Neoplasia Source Type: journals

Primary bilateral ovarian and uterine Burkitt’s lymphoma following chemotherapy for breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Burkitt’s lymphoma arising from the uterus/cervix is extremely rare and may present as a pelvic mass. Early diagnosis, aggressive chemotherapy, ±surgical intervention, plays an important role in management and survival of patients with Burkitt’s lymphoma. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1215-9Authors Mehrangiz Hatami, Albert Einstein College of Medicine and Montefiore Medical Center Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women’s Health Bronx NY USAKathleen Whitney, Albert Einstein College of Medicin...
Source: Archives of Gynecology and Obstetrics - September 16, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We speculate that an interaction between ritonavir/lopinavir and vincristine was responsible for this severe toxicity. Vincristine is transported by P-gp and is metabolized via CYP3A5. Ritonavir is a potent CYP3A5 isoenzyme and P-gp inhibitor. Lopinavir is also a P-gp inhibitor. Ritonavir and lopinavir might have delayed vincristine elimination. Clinicians should be aware of this possible interaction. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11096-009-9323-yAuthors Dominique Levêque, Hôpital de Hautepierre Department of Pharmacy Pharmacology avenue Molière 67000 Strasbourg FranceRa...
Source: Pharmacy World & Science - September 16, 2009 Category: Drugs & Pharmacology Tags: Pharmacy World & Science Source Type: journals

An Unusual Presentation of Burkitt Lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of Burkitt lymphoma presented as a unilateral pleural effusion in a 37-year-old man.Page: 961DOI: 10.1097/SMJ.0b013e3181b08d9cAuthors: Vu, Ho MD; Vildor, Esther MD; Reddy, Shilpa MD; Phillips, James MD; Meenrajan, Senthil MD; Edwards, Linda MD; Hosenpud, Janet MD (Source: Southern Medical Journal)
Source: Southern Medical Journal - September 15, 2009 Category: Journals (General) Tags: Abstract HTML PDF (168 K) Source Type: journals

Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic MechanismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lenalidomide and pomalidomide have both been evaluated clinically for their properties as anticancer agents, with lenalidomide being available commercially. We previously reported that both compounds cause cell cycle arrest in Burkitt's lymphoma and multiple myeloma cell lines by increasing the level of p21WAF-1 expression. In the present study, we unravel the molecular mechanism responsible for p21WAF-1 up-regulation using Namalwa cells as a human lymphoma model. We show that the increase of p21WAF-1 expression is regulated at the transcriptional level through a mechanism independent of p53. Using a combination of approac...
Source: Cancer Research - September 13, 2009 Category: Cancer & Oncology Authors: Escoubet-Lozach, L., Lin, I-L., Jensen-Pergakes, K., Brady, H. A., Gandhi, A. K., Schafer, P. H., Muller, G. W., Worland, P. J., Chan, K. W.H., Verhelle, D. Tags: Molecular Biology, Pathobiology, and Genetics Source Type: journals

Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BCL2 and MYC are oncogenes commonly deregulated in lymphomas. Concurrent BCL2 and MYC translocations (BCL2+/MYC+) were identified in 54 samples by karyotype and/or fluorescence in situ hybridization with the aim of correlating clinical and cytogenetic characteristics to overall survival. BCL2+/MYC+ lymphomas were diagnosed as B-cell lymphoma unclassifiable (BCLU; n = 36) with features intermediate between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL); DLBCL (n = 17), or follicular lymphoma (n = 1). Despite the presence of a t(14;18), 5 cases were BCL2 protein–negative. Nonimmunoglobulin gene/MYC (non-IG/...
Source: Blood - September 9, 2009 Category: Hematology Authors: Johnson, N. A., Savage, K. J., Ludkovski, O., Ben-Neriah, S., Woods, R., Steidl, C., Dyer, M. J. S., Siebert, R., Kuruvilla, J., Klasa, R., Connors, J. M., Gascoyne, R. D., Horsman, D. E. Tags: Free Research Articles, Lymphoid Neoplasia Source Type: journals

Cell cycle analysis and cytotoxic potential of Ruta graveolens against human tumor cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are reports on the presence of various compounds exerting different biological activities in Ruta graveolens, a plant of Rutaceae family. The aim of the present study was to evaluate in vitro cytotoxicity of the total extract of R. graveolens against tumor cell lines of different origin. Aerial parts of the plant was extracted with 70% ethanol by sonication method and cytotoxic activity was examined on RAJI, RAMOS, RPMI8866, U937, Jurkat, MDA-MB-453, MCF-7, LNCap-FGC-10, 5637, HeLa, SK-OV-3, A549, Mehr-80 and also peripheral blood mononuclear cells (PBMC) by the use of WST-1 assay. Results were expressed as IC50 ...
Source: Neoplasma - September 5, 2009 Category: Cancer & Oncology Authors: Varamini P, Soltani M, Ghaderi A Tags: Neoplasma Source Type: journals

[Viewpoint] Rethinking the responsiveness requirement for international researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Burkitt's lymphoma is endemic in Kenya and Uganda. It accounts for more than half of all childhood cancers in Africa but almost no malignant disease in developed countries. Yet, other diseases in east Africa, such as malaria, cause much greater mortality. For this reason, the UK's Nuffield Council suggests research on Burkitt's lymphoma is unresponsive to local health priorities and, therefore, unethical without further justification. (Source: LANCET)
Source: LANCET - September 3, 2009 Category: Journals (General) Authors: Rebecca Wolitz, Ezekiel Emanuel, Seema Shah Tags: Viewpoint Source Type: journals

Burkitt Lymphoma/Leukemia: Improving Prognosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Burkitt lymphoma/leukemia (BL) has become a very curable mature B-cell neoplasm. Current standard regimens, focused on the unique characteristics of this disease, are composed of cyclical intensive chemotherapy and aggressive intrathecal prophylaxis. Using this approach, complete response rates of 80%-90% are routinely achieved, and survival is now approaching 80% with the addition of rituximab to these intensive regimens. Prophylactic cranial irradiation and prolonged maintenance have no proven benefit and are not recommended. The more widespread use of highly active antiretroviral therapy in the HIV patient with BL h...
Source: Clinical Lymphoma and Myeloma - August 31, 2009 Category: Cancer & Oncology Authors: Kenkre VP, Stock W Tags: Clin lymphoma Myeloma Source Type: journals

Nodular fasciitis masquerading as relapsed Burkitt's lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: ANZ Journal of Surgery)
Source: ANZ Journal of Surgery - August 30, 2009 Category: Surgery Authors: A. Azad, J. Jayarajan Tags: LETTERS TO THE EDITOR Source Type: journals

An unusual self-limited clonal Mott cell proliferation with lymphoplasmacytic lymphoma-like features in a child with the Wiskott-Aldrich syndrome and Von Recklinghausen's neurofibromatosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a self-limited lymphoproliferation with features of lymphoplasmacytic lymphoma arising in a patient with the Wiskott-Aldrich syndrome. The patient also had stigmata of von Recklinghausen's neurofibromatosis. The tumor was composed of CD138+, IgGkappa+, CD20-, PAX-5- Mott cells and CD5-, CD10-, CD19+, CD20+, CD43- small lymphoid B-cells that partially expressed CD23. The lymphadenopathy spontaneously resolved after a period of less than a year, and the patient had remained free of detectable lymphoproliferation for almost 4 years. He then developed Burkitt's lymphoma of the left parapharyngeal space. It...
Source: Pathology, Research and Practice - August 24, 2009 Category: Pathology Authors: Rampisela D, Donner LR Tags: Pathol Res Pract Source Type: journals

IMP-3 is differentially expressed in normal and neoplastic lymphoid tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, although IMP-3 expression is seemingly restricted to physiologic germinal center B cells, its expression in lymphomas of germinal center B origin is less robust. However, there does appear to be some association with the latter group of lymphomas, which may prove to have diagnostic or therapeutic relevance as the biologic role of IMP-3 is further elucidated. (Source: Human Pathology)
Source: Human Pathology - August 21, 2009 Category: Pathology Authors: Rebecca L. King, Theresa Pasha, Michele R. Roullet, Paul J. Zhang, Adam Bagg Tags: Original Contributions Source Type: journals

Genetic background modulates susceptibility to oncogen-driven proliferation and lymphoma occurrence in mice carrying a deregulated c-myc transgeneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is well known that genetic variations significantly influence susceptibility to cancer in human. It is, thus, difficult to evaluate the relative contributions of modified genes because of the independent segregation of multiple alleles at multiple loci. In order to bypass this problem researchers have focused their attentions on inbred mice that have permitted investigation of disease phenotype in the presence of a homogenous background . Genetic homogeneity is a clear advantage especially for studies investigating oncogene overexpression or loss of tumor suppressor gene expression in a uniform population and needing a ...
Source: Leukemia Research - August 20, 2009 Category: Hematology Authors: Christelle Vincent-Fabert, Rémi Fiancette, Véronique Truffinet, Nadine Cogné, Michel Cogné, Yves Denizot Tags: e-page Letters (available online only) Source Type: journals

pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The majority of endemic BL cases from Uganda express pRb2, but somatic RBL2 mutations affecting the protein's nuclear localization signal appear to be rare. (Source: BioMed Central)
Source: BioMed Central - August 18, 2009 Category: Journals (General) Authors: Sam KalungiSolrun SteineHenry WabingaLeif BostadAnders Molven Source Type: journals

pRb2/p130 protein expression and RBL2mutation analysis in Burkitt lymphoma from UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The majority of endemic BL cases from Uganda express pRb2, but somatic RBL2 mutations affecting the protein's nuclear localization signal appear to be rare. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - August 18, 2009 Category: Pathology Authors: Sam KalungiSolrun SteineHenry WabingaLeif BostadAnders Molven Source Type: journals

Melatonin as a Modulator of Apoptosis in B-Lymphoma CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Melatonin is considered a promising antitumor agent, promoting apoptosis in tumor cells and contrasting it in normal cells. The basis for this selectivity is presumed to be the ability of melatonin to stimulate reactive oxygen species (ROS) production in tumor cells. Here we investigate the effect of melatonin on three types of human lymphocytes: normal blood lymphocytes, BL41 Burkitt lymphoma, and the cognate Epstein[ndash]Barr virus (EBV)-converted E2r. We found that melatonin promotes ROS production in all these cells. Melatonin protects BL41 from apoptosis in the same manner as normal lymphocytes, whereas E2r are unaff...
Source: Annals of the New York Academy of Sciences - August 14, 2009 Category: Science Authors: Laura Paternoster, Flavia Radogna, Augusto Accorsi, Maria Cristina Albertini, Giampiero Gualandi, Lina Ghibelli Tags: Part IV. Natural Compounds Regulating Apoptotic Cell Signaling Pathways Source Type: journals

Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Burkitt Lymphoma (BL) is listed in the World Health Organization (WHO) classification of lymphoid tumours as an "aggressive B-cell non-Hodgkin's lymphoma", characterized by a high degree of proliferation of the malignant cells and deregulation of the c-MYC gene. The main diagnostic challenge in BL is to distinguish it from diffuse large B-cell lymphoma (DLBCL). While in children BL and DLBCL types probably do not differ clinically, and the differential diagnosis between BL and DLBCL may theoretically appear clear-cut, in adults daily practice shows the existence of cases that have morphological features, immunophenotypic a...
Source: Hematological Oncology - August 10, 2009 Category: Hematology Authors: Cristiana Bellan, Lazzi Stefano, De Falco Giulia, Emily A. Rogena, Leoncini Lorenzo Source Type: journals

The incidence, clustering and characteristics of Burkitt lymphoma in the Northwest province of Cameroon.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The epidemiology of Burkitt lymphoma (BL) has never been documented in Cameroon. Data were collected from 16 hospitals, the Delegation of Public Health and the regional pathologist in the Northwest province of Cameroon on all BL cases. The incidence of BL in this region is 5.9/100,000 children aged <15 years/year - the second highest incidence documented to date. Significant clustering was also identified in Ndop, a low-lying region with a high malaria endemicity, at 21.5 cases/100,000 children aged <15 year/year (P < 0.001). PMID: 19671777 [PubMed - as supplied by publisher] (Source: Tropical Doctor)
Source: Tropical Doctor - August 10, 2009 Category: Tropical Medicine Authors: Wright NJ, Hesseling PB, McCormick P, Tchintseme F Tags: Trop Doct Source Type: journals

Mesial Temporal Sclerosis After Posterior Reversible Encephalopathy SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neither intrathecal methotrexate nor posterior reversible encephalopathy syndrome has previously been reported to result in mesial temporal sclerosis. Described here is the case of a boy with no risk factors for mesial temporal sclerosis who presented with posterior reversible encephalopathy syndrome and partial complex seizures 8 days after initiation of intrathecal methotrexate for treatment of Burkitt lymphoma, and who ultimately progressed to intractable temporal lobe epilepsy due to left mesial temporal sclerosis. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 7, 2009 Category: Neurology Authors: Mariam S. Aboian, Mithri R. Junna, Karl N. Krecke, Elaine C. Wirrell Tags: Case Reports Source Type: journals

Rituximab sensitizes a Burkitt lymphoma cell line to cell killing by X-irradiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to investigate the effects of rituximab (R) on cell death induced by X-irradiation in Raji lymphoma cells and to evaluate its mechanisms. We found the cell growth inhibition by irradiation was enhanced by additional rituximab exposure both in cells precultured with rituximab followed by irradiation (R + irradiation) or in cells treated in the reverse sequence (irradiation + R). R + irradiation combination treatment induced more apoptotic cells than irradiation and irradiation + R treatment as early as 12 h after treatment. At 24 h, both combination treatments, R + irradiation and irradiation + R, showed apo...
Source: Radiation and Environmental Biophysics - August 3, 2009 Category: Physics Authors: Fengling M, Fenju L, Wanxin W, Lijia Z, Jiandong T, Zu W, Xin Y, Qingxiang G Tags: Radiat Environ Biophys Source Type: journals

Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus Latent Membrane Protein-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data presented in this work indicate that EBV-induced immortalization leads to the remodelling of ER calcium homeostasis of B cells by LMP-1 that copies a previously unknown normal phenomenon taking place during antigen driven B cell activation. The functional remodelling of ER calcium homeostasis by down-regulation of SERCA3 expression constitutes a previously unknown mechanism involved in EBV-induced B cell immortalization. (Source: Molecular Cancer)
Source: Molecular Cancer - August 2, 2009 Category: Cancer & Oncology Authors: Olivier DellisAtousa ArbabianJean-Philippe BroulandTunde KovacsMartin RoweChristine ChomienneIrene JoabBela Papp Source Type: journals

[Effects of Epstein-Barr virus on host gene expression in Burkitt's lymphoma cell lines.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: EBV down-regulates most of the genes regulated by surface Ig cross-linking in the early stages of lytic cycle activation. These include genes involved in cell survival, signal transduction, transcription control and the immune response that may mediate EBV transformation of B-lymphocytes and others such as HDAC4 that may affect virus replication. PMID: 19664326 [PubMed - in process] (Source: Ai Zheng)
Source: Ai Zheng - July 31, 2009 Category: Cancer & Oncology Authors: Broderick P, Hubank M, Sinclair A Tags: Ai Zheng Source Type: journals

Clinicopathologic features and Epstein-Barr virus infection status of Burkitt's lymphoma in Guangzhou district.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: sBL is uncommon in Guangzhou district, mainly seen in boys and young men. Most patients had lymph node(s) involvement, showing similar morphology and immunophenotype as that of endemic BL. Type I EBV latent infection is associated with 28.57% of cases. PMID: 19664325 [PubMed - in process] (Source: Ai Zheng)
Source: Ai Zheng - July 31, 2009 Category: Cancer & Oncology Authors: Huang YH, Wu QL, Zong YS, Feng YF, Liang JZ, Hou JH, Shao Q, Fu J Tags: Ai Zheng Source Type: journals

[Nasopharyngeal carcinoma in sub-Saharan Africa: a tribute to Mr. Peter Clifford.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article deals with the latter, as studied and defined in depth during the 1960s and 70s by the Irish-born surgeon, Peter Clifford. Through his published works, he has influenced and helped define the field of head and neck cancer as it exists in Kenya. He also did pioneering work on the African childhood malignancy, Burkitt's lymphoma (BL). Both BL and NPC have been ultimately shown to be associated with the human herpes Epstein-Barr virus (EBV). This article is written as a tribute to Peter Clifford, focusing on his work on NPC, where he first defined the disease "hotspots" in the Kenyan Highlands, studied how best t...
Source: Ai Zheng - July 31, 2009 Category: Cancer & Oncology Authors: Griffin BE Tags: Ai Zheng Source Type: journals