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Intravenous contrast ultrasound examination using contrast-tuned imaging (CnTITM) and the contrast medium SonoVue® for discrimination between benign and malignant adnexal masses with solid componentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine whether intravenous contrast ultrasound examination is superior to gray-scale or power Doppler ultrasound for discrimination between benign and malignant adnexal masses with complex ultrasound morphology.In an international multicenter study, 134 patients with an ovarian mass with solid components or a multilocular cyst with more than 10 cyst locules, underwent a standardized transvaginal ultrasound examination followed by contrast examination using the contrast-tuned imaging technique and intravenous injection of the contrast medium SonoVue®. Time intensity curves were constructed, and peak intensity, area u...
Source: Ultrasound in Obstetrics and Gynecology - November 19, 2009 Category: Radiology Authors: A. C. Testa, D. Timmerman, V. Van Belle, E. Fruscella, C. Van Holsbeke, L. Savelli, E. Ferrazzi, F. P. G. Leone, H. Marret, F. Tranquart, C. Exacoustos, G. Nazzaro, D. Bokor, F. Magri, S. Van Huffel, G. Ferrandina, L. Valentin Source Type: journals

Intravenous contrast ultrasound examination using contrast-tuned imaging (CnTI) and the contrast medium SonoVue(R) for discrimination between benign and malignant adnexal masses with solid components.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Findings on ultrasound contrast examination differed between benign and malignant tumors but there was a substantial overlap in contrast findings between benign and borderline tumors. It appears that ultrasound contrast examination is not superior to conventional ultrasound techniques, which also have difficulty in distinguishing between benign and borderline tumors, but can easily differentiate invasive malignancies from other tumors. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19924735 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - November 18, 2009 Category: Radiology Authors: Testa AC, Timmerman D, Van Belle V, Fruscella E, Van Holsbeke C, Savelli L, Ferrazzi E, Leone FP, Marret H, Tranquart F, Exacoustos C, Nazzaro G, Bokor D, Magri F, Van Huffel S, Ferrandina G, Valentin L Tags: Ultrasound Obstet Gynecol Source Type: journals

Mammary Tumor Development in Dogs Is Associated with BRCA1 and BRCA2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study indicates that BRCA1 and BRCA2 contribute to the risk of CMT in ESS, suggesting that dogs may serve as a good model for human breast cancer. [Cancer Res 2009;69(22):8770–4] (Source: Cancer Research)
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Authors: Rivera, P., Melin, M., Biagi, T., Fall, T., Haggstrom, J., Lindblad-Toh, K., von Euler, H. Tags: Molecular Biology, Pathobiology, and Genetics Source Type: journals

Apigenin Phytonutrient Cuts Ovarian Cancer RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is not the first to indicate a connection between apigenin and decreased cancer risk. Previous research has found that apigenin decreases the structural stability and inhibits the expression of a protein that is involved in the migration of ovarian cancer cells to other parts of the body. It has also been more directly observed to interfere with the movement of ovarian cancer cells. Apigenin has also been shown to inhibit the expression in ovarian cancer cells of a protein linked to the development of blood vessels in tumors, as well as overall tumor growth.Other studies have found that apigenin inhibits the gro...
Source: NaturalNews.com - November 10, 2009 Category: Consumer Health Advice Source Type: news

Unique vascular tumor primary arising in the liver and exhibiting histopathological features consistent with so-called polymorphous hemangioendotheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reported herein is an unusual vascular tumor primary arising in the liver and exhibiting unique histopathological features. A 47-year-old woman underwent left hepatectomy because of a large hepatic mass. On histology the tumor had a composite pattern, consisting of angiomatous, retiform and solid areas, formed by oval to cuboidal to spindle cells, that expressed only endothelial markers (CD31 and factor VIII-related antigen). These findings led to the diagnosis of a low-grade vascular neoplasm with morphological features consistent with so-called polymorphous hemangioendothelioma. The tumor was completely resected. At 24 m...
Source: Pathology International - October 30, 2009 Category: Pathology Authors: Lorenzo Cobianchi, Marco Lucioni, Renato Rosso, Sandro Zonta, Giacomo Fiandrino, Mario Alessiani, Marco Doni, Alberta Ferrari, Umberto Magrini, Marco Paulli, Paolo Dionigi Source Type: journals

Proteins from the Wnt pathway are involved in the pathogenesis and progression of mammary phyllodes tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results suggest that alterations in the Wnt pathway are important in the progression and in the epithelial and stromal interactions in PTs. They have important implications for understanding the pathogenesis of these uncommon but clinically important tumours. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Karim, R Z, Gerega, S K, Yang, Y H, Horvath, L, Spillane, A, Carmalt, H, Scolyer, R A, Lee, C S Tags: Original articles Source Type: journals

Aberrant expression of p27Kip1-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the expressions of p27Kip1-interacting proteins, i.e., p27Kip1, Skp2, Cks1, cyclin A, cyclin E, and the Ki-67 labeling index (LI), were analyzed in 25 CCAFs (11 benign and 14 borderline) and 15 CCAF-associated CCAs, and compared with the expression status of each protein in the 23 previously studied endometriosis-associated CCAs. Although aberrant expression of all p27Kip1-interacting proteins was more frequent in the CCAF-associated CCAs than in the benign CCAFs, statistical significance was found only for Cks1 overexpression. The frequencies of p27Kip1 downregulation and overexpression of Skp2 and cycli...
Source: Virchows Archiv - October 23, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These results suggest that levothyroxine treatment is not a reasonable option in euthyroid patients with CIU and thyroid autoimmunity. Augmentation of cytokine production after levothyroxine treatment seems to be related to the immunomodulatory effects of TSH-suppressive treatment. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. Kiyici, O. O. Gul, E. B. Baskan, S. Hacioglu, F. Budak, E. Erturk, S. Imamoglu Source Type: journals

Efficacy of dynamic contrast enhanced-MRI in distinguishing benign and malignant breast lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion DCE-MRI combined with morphology and dynamic enhanced feature of breast lesion has well efficacy to differentiate malignant tumor from benign lesions. Content Type Journal ArticleDOI 10.1007/s10330-009-0149-9Authors Tieqiao Du, Fuxing Hospital Affiliated to Capital University of Medical Sciences Department of Radiology Beijing 100038 ChinaBaozhi Ding, Fuxing Hospital Affiliated to Capital University of Medical Sciences Department of Radiology Beijing 100038 ChinaChunyu Sang, Fuxing Hospital Affiliated to Capital University of Medical Sciences Department of Radiology Beijing 100038 ChinaChao ...
Source: The Chinese-German Journal of Clinical Oncology - October 21, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Women may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are a...
Source: Diagnostic Histopathology - October 12, 2009 Category: Pathology Authors: Ui-Soon Khoo, Dan-Hua Shen, Richard Wing-Cheuk Wong, Annie Nga-Yin Cheung Tags: Mini-Symposium: Pathology of the Uterus and Fallopian Tube Source Type: journals

[Ovarian low malignant potential tumor: How to preserve fertility?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian low malignant potential tumor account for 10 to 20 percent of ovarian epithelial tumors. They differ from typical ovarian cancers in that they do not grow into the ovarian stroma. Likewise, if they spread outside the ovary, for example, into the abdominal cavity, they do not usually grow into the lining of the abdomen. These cancers tend to affect women at a younger age than the typical ovarian cancers and are less life-threatening than most ovarian cancers. Guidelines for surgical treatment of borderline ovarian tumors are similar to those for ovarian cancer and include hysterectomy with bilateral salpingo-oop...
Source: Gynecologie, Obstetrique & Fertilite - October 8, 2009 Category: OBGYN Authors: Koskas M, Madelenat P, Yazbeck C Tags: Gynecol Obstet Fertil Source Type: journals

The Glucocorticoid Receptor Is Overexpressed in Malignant Adrenocortical Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The immunohistochemical finding of nuclear GR staining identified ACCs with high diagnostic accuracy. We propose that GR immunohistochemistry may complement the Weiss score in the diagnosis of ACC in cases that display borderline histology. The possibility that GR is transcriptionally active in these tumors, and may therefore be a therapeutic target, requires further study. PMID: 19820023 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 8, 2009 Category: Endocrinology Authors: Tacon LJ, Soon PS, Gill AJ, Chou AS, Clarkson A, Botling J, Stalberg PL, Skogseid BM, Robinson BG, Sidhu SB, Clifton-Bligh RJ Tags: J Clin Endocrinol Metab Source Type: journals

[Peritoneal serous borderline tumor discovered during a cesarean section. A case report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During a caesarean section performed in a 36-year-old woman, we discovered small granulations on the pelvic peritoneum. Biopsies were performed. The diagnosis of primitive borderline serous tumor was confirmed by pathologists. The patient was operated twice: once for diagnostic evaluation, and again six months later. A radical gesture was then decided for therapeutic purposes. The optimal attitude regarding these borderline peritoneal tumors in young women remains difficult and requires a multidisciplinary workout between pathologists and surgeons. PMID: 19819645 [PubMed - as supplied by publisher] (Source: Journal...
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - October 8, 2009 Category: OBGYN Authors: Raiga J, Ben Abdelkrim S, Dupré F, Treisser A Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: journals

Preoperative weekly cisplatin, epirubicin, and paclitaxel (PET) improves prognosis in locally advanced breast cancer patients: an update of the Southern Italy Cooperative Oncology Group (SICOG) randomised trial 9908.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The PET weekly regimen significantly improves both DMFS and OS in LABC patients, compared with the triweekly ET combination. The therapeutic advantage is limited to patients with highly aggressive tumours. PMID: 19815652 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 7, 2009 Category: Cancer & Oncology Authors: Frasci G, D'Aiuto G, Comella P, D'Aiuto M, Di Bonito M, Ruffolo P, Iodice G, Petrillo A, Lastoria S, Oliviero P, Capasso I, Montella M, Siani C, Santangelo M, Vizioli L, Comella G, Tags: Ann Oncol Source Type: journals

ARTICLE: Reproductive Outcomes in Male Childhood Cancer Survivors: A Linked Cancer-Birth Registry AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Most pregnancies resulting in live births among partners of male childhood cancer survivors were not at significantly greater risk of complications vs comparison subjects. However, there remains the possibility that prior cancer therapy may affect male germ cells with some effects on progeny and on female partners. (Source: Archives of Pediatrics)
Source: Archives of Pediatrics - October 5, 2009 Category: Pediatrics Authors: Chow, E. J., Kamineni, A., Daling, J. R., Fraser, A., Wiggins, C. L., Mineau, G. P., Hamre, M. R., Severson, R. K., Drews-Botsch, C., Mueller, B. A. Tags: Men's Health, Men's Health, Other, Oncology, Oncology, Other, Pediatrics, Neonatology and Infant Care, Pediatrics, Other, Women's Health, Pregnancy and Breast Feeding, Prognosis/ Outcomes Article Source Type: journals

Reproductive Outcomes in Male Childhood Cancer Survivors: A Linked Cancer-Birth Registry Analysis [Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Most pregnancies resulting in live births among partners of male childhood cancer survivors were not at significantly greater risk of complications vs comparison subjects. However, there remains the possibility that prior cancer therapy may affect male germ cells with some effects on progeny and on female partners. (Source: Archives of Pediatrics)
Source: Archives of Pediatrics - October 5, 2009 Category: Pediatrics Authors: Chow, E. J., Kamineni, A., Daling, J. R., Fraser, A., Wiggins, C. L., Mineau, G. P., Hamre, M. R., Severson, R. K., Drews-Botsch, C., Mueller, B. A. Tags: Men's Health, Men's Health, Other, Oncology, Oncology, Other, Pediatrics, Neonatology and Infant Care, Pediatrics, Other, Women's Health, Pregnancy and Breast Feeding, Prognosis/ Outcomes Article Source Type: journals

[Value of color Doppler ultrasonography, contrast-enhanced ultrasound and serum CA-125 detection in differential diagnosis of ovarian masses.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
OBJECTIVE: To assess the value of color Doppler ultrasonography, contrast-enhanced ultrasound and detection of serum CA-125 levels in the differential diagnosis of ovarian masses. METHODS: The findings of color Doppler ultrasonography, contrast-enhanced ultrasound and the serum levels of CA-125 were comparatively analyzed in 65 patients with ovarian masses, and the diagnostic accuracy of the 3 methods was estimated. RESULTS: Of the 65 cases of ovarian masses, 21 of the 35 patients with benign ovarian masses had serum CA-125 levels below 35 U/ml , and 28 of the 30 patients with malignant masses showed CA-125 levels over...
Source: Journal of Southern Medical University - October 1, 2009 Category: Universities & Medical Training Authors: Zhou Q, Liu BL, Jiang J, Lei XY Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

Phyllodes Tumour of the Breast: Clinicopathological Analysis of Recurrent vs. Non-recurrent Cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: WLE seems to be the initial procedure of choice for all PTs, and mastectomy for recurrent tumours. Further studies are needed to define the role of adjuvant therapies. PMID: 19892625 [PubMed - in process] (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 1, 2009 Category: Surgery Authors: Bhargav PR, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK Tags: Asian J Surg Source Type: journals

Borderline ovarian tumors and extended patient follow-up: An individual institution's experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a physician group's retrospective experience treating BOT patients at a single institution. Patient demographics, disease pathology, treatment type (surgery, chemotherapy), and patient surveillance (e.g., disease-free survival (DFS), overall survival, follow-up via CA-125/radiology/physical exam) data were reviewed in all cases.In the present study, 78 BOT patients treated from April 2001 until February 2009 were identified and confirmed via pathologic diagnosis. The majority (87%) underwent surgery, although nearly 13% of patients also received adjuvant chemotherapy. In the study population, 12% of the patients ...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Mark A. Rettenmaier, Katrina Lopez, Lisa N. Abaid, John V. Brown III, John P. Micha, Bram H. Goldstein Source Type: journals

Site-specific relapse pattern of the triple negative tumors in Chinese breast cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Based on the site-specific spread pattern in different subgroups, the triple negative category of breast cancers in the Chinese population exhibits a different pattern of relapse, which indicates that different organotropism may be due to the different intrinsic subtypes. A better knowledge of the triple negative category is warranted for efficacious systemic regimens to decrease and/or delay the relapse hazard. (Source: BMC Cancer)
Source: BMC Cancer - September 23, 2009 Category: Cancer & Oncology Authors: Yanping LinWenjin YinTingting YanLiheng ZhouGenhong DiJiong WuZhenzhou ShenZhimin ShaoJinsong Lu Source Type: journals

Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidneyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a mucinous borderline tumor arising from a mixed epithelial and stromal tumor of left kidney (MESTK). The patient was an 82-year-old woman who presented with gross hematuria and recurrent urinary tract infection for years. The patient had a cytoscopy with a retrograde pyelogram, which indicated a dilated left kidney with a central mass lesion. Subsequently, she underwent a radical left nephrectomy. Cross-sections of left kidney showed a 4.5 × 3.5 × 1.5 cm ill-defined cystic lesion with mucinous and solid areas. Histologic sections of the lesion showed numerous variable-sized dilated cysts with ...
Source: Virchows Archiv - September 16, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Confidence of expert ultrasound operators in making a diagnosis of adnexal tumor: effect on diagnostic accuracy and interobserver agreementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess the degree of confidence with which expert ultrasound operators make a diagnosis of benign, borderline and invasive malignant ovarian tumors and its effect on diagnostic accuracy and interobserver agreement.Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed by three expert ultrasound operators who had not performed the original real-time ultrasound examination. The experts classified the tumors as benign, borderline or invasive malignant and they also indicated the degree of confidence with which the...
Source: Ultrasound in Obstetrics and Gynecology - September 14, 2009 Category: Radiology Authors: J. Yazbek, L. Ameye, A. C. Testa, L. Valentin, D. Timmerman, T. K. Holland, C. Van Holsbeke, D. Jurkovic Source Type: journals

Confidence of expert ultrasound operators in making a diagnosis of adnexal tumor: effect on diagnostic accuracy and interobserver agreement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The accuracy of expert ultrasound operators using pattern recognition depends on the degree of certainty with which the diagnosis is made. Interobserver variability is also influenced by the operators' confidence in making the diagnosis. Our findings suggest that the level of confidence with which the diagnosis is made should be included in the ultrasound report. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19757401 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - September 14, 2009 Category: Radiology Authors: Yazbek J, Ameye L, Testa AC, Valentin L, Timmerman D, Holland TK, Van Holsbeke C, Jurkovic D Tags: Ultrasound Obstet Gynecol Source Type: journals

Use of ultrasound pattern recognition by expert operators to identify borderline ovarian tumors: a study of diagnostic performance and interobserver agreementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess the accuracy and reproducibility of ultrasound 'pattern recognition' for the diagnosis of borderline ovarian tumors by asking experienced ultrasound operators to evaluate representative images of different types of adnexal tumor.Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed by three expert sonologists who had not performed the original real-time ultrasound examination. The outcome measures included diagnostic accuracy and interobserver agreement in the diagnosis of benign, borderline or invasive...
Source: Ultrasound in Obstetrics and Gynecology - September 9, 2009 Category: Radiology Authors: J. Yazbek, L. Ameye, D. Timmerman, A. C. Testa, L. Valentin, T. K. Holland, C. Van Holsbeke, D. Jurkovic Source Type: journals

Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms: real association or just a coincidence?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association. PMID: 19734627 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Gill KR, Scimeca D, Stauffer J, Krishna M, Woodward TA, Jamil LH, Wallace MB, Nguyen JH, Raimondo M Tags: JOP Source Type: journals

Ultrasound methods to distinguish between malignant and benign adnexal masses in the hands of examiners with different levels of experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine the effect of an ultrasound training course on the performance of pattern recognition when used by less experienced examiners and to compare the performance of pattern recognition, a logistic regression model and a scoring system to estimate the risk of malignancy between examiners with different levels of experience.Using ultrasound images of selected adnexal masses, two trainees classified the masses as benign or malignant by using pattern recognition both before and after they had attended a theoretical gynecological ultrasound course. They also classified the masses by using a logistic regression model and...
Source: Ultrasound in Obstetrics and Gynecology - September 8, 2009 Category: Radiology Authors: C. Van Holsbeke, A. Daemen, J. Yazbek, T. K. Holland, T. Bourne, T. Mesens, L. Lannoo, B. De Moor, E. De Jonge, A. C. Testa, L. Valentin, D. Jurkovic, D. Timmerman Source Type: journals

Ultrasound methods to distinguish between malignant and benign adnexal masses in the hands of examiners with different levels of experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Theoretical ultrasound teaching did not seem to improve the performance of pattern recognition in the hands of trainees. A logistic regression model and a scoring system to classify adnexal masses as benign or malignant perform less well when they were used by inexperienced examiners than when used by an expert. Before using a model or a scoring system, experience and/or proper training are likely to be of paramount importance if diagnostic performance is to be optimized. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19736644 [PubMed - as supplied by publisher] (Source: The Ultras...
Source: The Ultrasound Review of Obstetrics and Gynecology - September 7, 2009 Category: Radiology Authors: Van Holsbeke C, Daemen A, Yazbek J, Holland TK, Bourne T, Mesens T, Lannoo L, De Moor B, De Jonge E, Testa AC, Valentin L, Jurkovic D, Timmerman D Tags: Ultrasound Obstet Gynecol Source Type: journals

A Multi-Institutional Phase II Study of the Efficacy and Tolerability of Lapatinib in Patients with Advanced Hepatocellular Carcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lapatinib is well-tolerated but seems to benefit only a subgroup of patients for whom predictive molecular or clinical characteristics are not yet fully defined. (Clin Cancer Res 2009;15(18):5895-901). PMID: 19737952 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 7, 2009 Category: Cancer & Oncology Authors: Bekaii-Saab T, Markowitz J, Prescott N, Sadee W, Heerema N, Wei L, Dai Z, Papp A, Campbell A, Culler K, Balint C, O'Neil B, Lee RM, Zalupski M, Dancey J, Chen H, Grever M, Eng C, Villalona-Calero M Tags: Clin Cancer Res Source Type: journals

Proximal-Type Epithelioid Sarcoma in the Groin Presenting as a Diagnostic Dilemma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of proximal-type epithelioid sarcoma that presented as an inguinal mass in a 47-year-old man. Histologically, the tumor consisted of diffuse sheets of epithelioid cells with scattered rhabdoid morphology. By immunohistochemistry, the neoplastic cells expressed cytokeratin, epithelial membrane antigen, vimentin, CD34, CD99 and showed complete loss of nuclear INI1 protein expression. Fluorescence in situ hybridization was considered borderline for 22q deletion. We present this case to emphasize the importance of diagnosing this uncommon tumor and the role of INI1 immunohistochemistry in establishing the diag...
Source: Pathology Oncology Research - September 7, 2009 Category: Pathology Authors: Mannan AA, Rifaat AA, Kahvic M, Kapila K, Mallik M, Grover VK, Bharati C, Perry A Tags: Pathol Oncol Res Source Type: journals

Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Programmed cell death 4 (Pdcd4) is a novel tumour suppressor and originally identified as a neoplastic transformation inhibitor. The aim of this study was to investigate the expression, prognostic significance and potential function of Pdcd4 in ovarian cancer. Results: The expression of Pdcd4 was examined in 30 normal ovarian tissues, 16 borderline and 93 malignant ovarian tissues. A continuous down regulation of Pdcd4 expression in the sequence of normal, borderline and malignant tissues was observed. The expressions of Pdcd4 in both ovarian borderline tissues and carcinomas were significantly lower than the e...
Source: Molecular Cancer - September 2, 2009 Category: Cancer & Oncology Authors: Na WeiStephanie LiuThomas LeungKar TamXiao LiaoAnnie CheungKaren ChanHextan Ngan Source Type: journals

Blue Nevi and Related TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article succinctly describes the common dermal dendritic proliferations and updates readers on newly classified entities and variants. The differential diagnosis of the main entities and strategies to distinguish them from their melanocytic and nonmelanocytic mimics is also presented. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - September 1, 2009 Category: Pathology Authors: Pushkar A. Phadke, Artur Zembowicz Source Type: journals

[Original articles] Screening for familial ovarian cancer: poor survival of BRCA1/2 related cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Annual surveillance, by transvaginal ultrasound scanning and serum CA125 measurement, in women at increased familial risk of ovarian cancer is ineffective in detecting tumours at a sufficiently early stage to influence substantially survival in BRCA1/2 carriers. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - August 31, 2009 Category: Genetics & Stem Cells Authors: Evans, D G, Gaarenstroom, K N, Stirling, D, Shenton, A, Maehle, L, Dorum, A, Steel, M, Lalloo, F, Apold, J, Porteous, M E, Vasen, H F A, van Asperen, C J, Moller, P Tags: Original articles Source Type: journals

Single Port Access Laparoscopic Adnexal SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The single port access laparoscopic adnexal surgery was safe and feasible and provided almost no visual scar. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - August 31, 2009 Category: OBGYN Authors: Tae-Joong Kim, Yoo-Young Lee, Min Jae Kim, Chul Jung Kim, Heeseok Kang, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae Tags: Instruments and Techniques Source Type: journals

Pseudomyxoma peritonei associated with primary mucinous borderline tumor of the renal pelvicalyceal system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary mucinous cystic neoplasms are extraordinarily rare tumors of the kidney. Herein, we present a case of a 52-year-old man who presented with painless hematuria and mucusuria. The nephrectomy showed a markedly enlarged kidney replaced by a large cystic mass filled with mucin and with almost complete destruction of the renal parenchyma. Histologically, the mass was lined primarily by simple mucinous epithelium and showed foci of adenomatous (borderline) change with focal areas exhibiting intraepithelial carcinoma. No invasion was documented after extensive sampling of the tumor. A pathologic diagnosis of intraepith...
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Rao P, Pinheiro N, Franco M, Ra S, Costa H, Manzano J, Paner GP, Silva EG, Amin MB Tags: Arch Pathol Lab Med Source Type: journals

[Claudin expression in different pancreatic cancers and its significance in differential diagnostics.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.)...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Borka K Tags: Magy Onkol Source Type: journals

The Expression and Diagnostic Utility of p63 in the Female Genital TractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
p63 plays a key role in epithelial development in various organs, being expressed in myoepithelial cells and in basal cells of stratified epithelia. In the female genital tract, p63 is expressed in the basal and parabasal cells of mature cervical, vaginal and vulval squamous epithelium, and also in cervical reserve cells at the transformation zone and in immature metaplastic and atrophic cervical squamous epithelium. In this review, the diagnostic utility of p63 immunohistochemical staining in various pathologic scenarios within the female genital tract is discussed. Cervical microglandular hyperplasia is p63 positive with...
Source: Advances in Anatomic Pathology - August 29, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Conservative resection for benign tumors of the proximal pancreas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CR is a safe and effective procedure for patients with benign tumors in the proximal pancreas, with careful CCI-PJ and postoperative MCCL. PMID: 19705501 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 27, 2009 Category: Gastroenterology Authors: Huang H, Dong X, Gao SL, Wu YL Tags: World J Gastroenterol Source Type: journals

Radiation therapy recommended for phyllodes tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Margin-negative surgical resection combined with adjuvant radiation therapy is effective for local control of borderline and malignant phyllodes tumors, a rare type of breast cancer, according to a new study. (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - August 27, 2009 Category: Radiology Source Type: info

Ovarian Low-grade and High-grade Serous Carcinoma: Pathogenesis, Clinicopathologic and Molecular Biologic Features, and Diagnostic ProblemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier system in which tumors are subdivided into low grade and high grade has been proposed. This approach is simplistic, reproducible, and based on biologic evidence indicating that both tumors develop via different pathways. Low-grade serous carcinomas exhibit low-grade nuclei with infrequent mitotic figures. They evolve from adenofibromas or borderline tumors, have frequent mutations of the KRAS, BRAF, or ERBB2 genes, and lack TP53 mutations (Type I pathway). The progression to invasive carcinoma is a slow step-wise process. Low-grade tumors ...
Source: Advances in Anatomic Pathology - August 26, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Obesity is a strong risk factor for breast cancer in postmenopausal women and adverse prognostic indicator regardless of menopausal status. Leptin is an important regulator of adipose tissue mass and has been associated with tumor cell growth. Leptin exerts its effects through interaction with the leptin receptor (LEPR). We investigated whether genetic variations in the leptin (LEP) and LEPR genes are associated with risk of breast cancer, or once diagnosed, with survival. The polymorphisms LEP G-2548A and LEPR Q223R were characterized in population-based study consisting of mostly European-American ...
Source: Breast Cancer Research and Treatment - August 20, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Nuclear Snail1 expression seems to be related to tumour progression, and expression in borderline tumours indicates a role for Snail1 in early epithelial ovarian tumour development. Snail1 also appears to function more generally in tissue remodelling as positive staining was demonstrated in stromal cells. (Source: BMC Cancer)
Source: BMC Cancer - August 19, 2009 Category: Cancer & Oncology Authors: Hanna TuhkanenYlermi SoiniVeli-Matti KosmaMaarit AnttilaReijo SironenKirsi HamalainenLaura KukkonenIsmo VirtanenArto Mannermaa Source Type: journals

Radiation Dose and Breast Cancer Risk in the Childhood Cancer Survivor Study [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Results confirm the radiation sensitivity of the breast in girls age 10 to 20 years but do not demonstrate a strong effect of age at exposure within this range. Irradiation of the ovaries at doses greater than 5 Gy seems to lessen the carcinogenic effects of breast irradiation, most likely by reducing exposure of radiation-damaged breast cells to stimulating effects of ovarian hormones. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - August 17, 2009 Category: Cancer & Oncology Authors: Inskip, Robison, Stovall, Smith, Hammond, Mertens, Whitton, Diller, Kenney, Donaldson, Meadows, Neglia Tags: Epidemiology, Cancer Etiology, Long Term Survival & Late Effects, Outcomes Research Breast Cancer Source Type: journals

Clinical impact of under-diagnosis by frozen section examination is minimal in borderline ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The under-diagnosis by frozen section examination did not compromise the outcome in patients with BOTs, although under-diagnosis was associated with more conservative surgery. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - August 11, 2009 Category: Cancer & Oncology Authors: K. Kim, H.H. Chung, J.W. Kim, N.H. Park, Y.S. Song, S.B. Kang Tags: Original Articles Source Type: journals

Are ultrasonographic myoma characteristics associated with blood loss at delivery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of myomas in pregnancy is associated with greater blood loss at delivery. The aim of this study was to evaluate whether the sonographic characteristics of myomas can predict blood loss at delivery in women with large myomas.Among women who underwent second-trimester ultrasound screening at our department between January 1996 and December 2004, 251 had at least one myoma with a mean diameter [ge] 5 cm. Number of myomas (single vs. multiple), maximum diameter of the largest myoma, sum of the maximum diameter of each myoma, change in size of myomas between first and last scan, and location in relation to the plac...
Source: Ultrasound in Obstetrics and Gynecology - August 9, 2009 Category: Radiology Authors: M. Andreani, P. Vergani, A. Ghidini, A. Locatelli, S. Ornaghi, J. C. Pezzullo Source Type: journals

Are ultrasonographic myoma characteristics associated with blood loss at delivery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In women with large myomas, the presence of multiple tumors is independently associated with heavier blood loss at delivery but not with postpartum hemorrhage of >/= 1000 mL. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19670350 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - August 9, 2009 Category: Radiology Authors: Andreani M, Vergani P, Ghidini A, Locatelli A, Ornaghi S, Pezzullo JC Tags: Ultrasound Obstet Gynecol Source Type: journals

Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sertoli-Leydig cell tumor (SLCT) is a rare tumor involving the ovary. Approximately 20% of SLCT are associated with heterologous elements that are either of endodermal or mesodermal origin. The gastrointestinal-type epithelium is the most commonly described endodermal heterologous element. SLCT with benign and borderline mucinous neoplasm has been reported in the literature. However, SLCT with mucinous adenocarcinoma as heterologous element has been rarely documented. Herein, we describe a rare case of intermediately differentiated Sertoli-Leydig cell tumor with mucinous adenocarcinoma as the heterologous element in a ...
Source: Pathology, Research and Practice - August 9, 2009 Category: Pathology Authors: Virk R, Lu D Tags: Pathol Res Pract Source Type: journals

Identification of borderline thyroid tumors by gene expression array analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A subset of follicular lesions of the thyroid is encapsulated similar to follicular adenomas but with partial nuclear features suggestive of papillary thyroid carcinoma (PTC), raising the possibility of biologically borderline tumors.Gene expression profiling and advanced significance analyses were performed on 50 histologically unequivocal benign and malignant tumors, and a list of 61 differentially expressed genes was generated. By using this 61-gene list, unsupervised hierarchical and K-means cluster analyses were performed on 40 additional tumors, including 15 histologically borderline tumors, 11 benign tumors, and 14 ...
Source: Cancer - August 6, 2009 Category: Cancer & Oncology Authors: Nimmi Arora, Theresa Scognamiglio, Carrie C. Lubitz, Tracy A. Moo, Meredith A. Kato, Baixin Zhu, Rasa Zarnegar, Yao-Tseng Chen, Thomas J. Fahey III Source Type: journals

Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We found a glycolytic phenotype in a high percentage of breast cancer samples. Inhibition of glycolysis might evolve as a future option for breast cancer therapy. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0652-yAuthors Melanie Schmidt, University of Wuerzburg Department of Gynaecology and Obstetrics Josef-Schneider-Strasse 4 Wuerzburg 97080 GermanyHans-Ullrich Voelker, University of Wuerzburg Department of Pathology Josef-Schneider-Strasse 2 Wuerzburg 97080 GermanyMichaela Kapp, University of Wuerzburg Department of Gynaecology and Obstetrics Josef-Schneider-...
Source: Journal of Cancer Research and Clinical Oncology - August 4, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Association between tumor tissue TIMP-1 levels and objective response to first-line chemotherapy in metastatic breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In a previous study from our laboratory, high tumor levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) have been associated with an adverse response to chemotherapy in metastatic breast cancer suggesting that TIMP-1, which is known to inhibit apoptosis, may be a new predictive marker in this disease. The purpose of this study was to investigate the association between TIMP-1 and objective response to chemotherapy in an independent patient population consisting of patients with metastatic breast cancer from Sweden and Denmark. TIMP-1 was measured using ELISA in 162 primary tumor extracts fro...
Source: Breast Cancer Research and Treatment - August 3, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

The circadian gene NPAS2 is a novel prognostic biomarker for breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mounting evidence suggests that neuronal PAS domain protein 2 (NPAS2) and other circadian genes are involved in tumorigenesis and tumor growth, possibly through their control of cancer-related biologic pathways. A missense polymorphism in NPAS2 (Ala394Thr) has been shown to be associated with risk of human tumors including breast cancer. The current study further examined the prognostic significance of NPAS2 in breast cancer by genotyping the Ala394Thr polymorphism and measuring NPAS2 expression. DNA extracted from 348 breast cancer tissue samples was analyzed for NPAS2 genotype using the TaqMan allel...
Source: Breast Cancer Research and Treatment - July 31, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals