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Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - May 18, 2009 Category: Pathology Authors: Jin Hyung Heo, Kwang Il Kim, Sun Young Lee, Tae Heon Kim, Haeyoun Kang, Hee Jung An Source Type: journals

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 9, 2009 Category: Cancer & Oncology Authors: Shimada M, Kigawa J, Ohishi Y, Yasuda M, Suzuki M, Hiura M, Nishimura R, Tabata T, Sugiyama T, Kaku T Tags: Gynecol Oncol Source Type: journals

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinou...
Source: Human Pathology - March 9, 2009 Category: Pathology Authors: Masafumi Yasunaga, Yoshihiro Ohishi, Yoshinao Oda, Munechika Misumi, Atsuko Iwasa, Shuichi Kurihara, Izumi Nishimura, Emi Okuma, Hiroaki Kobayashi, Norio Wake, Masazumi Tsuneyoshi Tags: Original Contributions Source Type: journals

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous bor...
Source: Human Pathology - March 6, 2009 Category: Pathology Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Tags: Hum Pathol Source Type: journals

Ovarian epithelial dysplasia after ovulation induction: time and dose effectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS There is probably a relationship between ovarian epithelial dysplasia and either ovulation inducing drugs or infertility. By Fathalla’s incessant ovulation theory, ‘the dose effect and the time effect’ of ovarian stimulation may explain ovarian dysplasia formation. (Source: Human Reproduction)
Source: Human Reproduction - December 8, 2008 Category: Reproduction Medicine Authors: Chene, G., Penault-Llorca, F., Le Bouedec, G., Mishellany, F., Dauplat, M.M., Jaffeux, P., Aublet-Cuvelier, B., Pouly, J.L., Dechelotte, P., Dauplat, J. Tags: Infertility Source Type: journals

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - November 4, 2008 Category: Pathology Authors: Sung Ho Hwang, Sang Jae Noh, Hyong Jong Kwak, Kyung Ryoul Kim, Ho Sung Park, Woo Sung Moon, Myoung Ja Chung, Keun Sang Kwon, Kwan Sik Kim, Kyu Yun Jang Source Type: journals

Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saita...
Source: Archives of Gynecology and Obstetrics - October 21, 2008 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest differences in the relation of ovarian cysts and endometriosis with risk of specific subtypes of ovarian cancer as well as the possibility that ovarian surgery in women with these conditions may lower the risk of invasive disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9207-9Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristin...
Source: Cancer Causes and Control - August 15, 2008 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: journals

mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age differenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to examine mtDNA sequence variants in 118 frozen tissues of three subtypes of epithelial ovarian cancer (serous, n=48 endometrioid, n=47 and mucinous, n =23) and matched paracancerous normal tissues (n= 18) in relation to racial/ethnic and age differences. Restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-based sequencing were used to evaluate two regions of mtDNA spanning 5317 to 7608 and 8282 to 10110 bp and including ND subunits 2, 3, MT-COI, II, and III, ATPase 8, a part of ATPase 6, and tRNA genes in frozen ovarian tissues obtained from the southern reg...
Source: BioMed Central - July 28, 2008 Category: Journals (General) Authors: Felix O Aikhionbare, Sharifeh Mehrabi, Winston Thompson, Xuebiao Yao, William Grizzle and Edward Partridge Source Type: journals

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was pos...
Source: Cancer Control - June 14, 2008 Category: Cancer & Oncology Authors: Olsen CM, Nagle CM, Whiteman DC, Purdie DM, Green AC, Webb PM, Tags: Int J Cancer Source Type: journals

Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel class of putative progestin binding proteins has been recently identified as potential mediators of rapid nongenomic hormone actions. The proteins designated membrane progestin receptor (mPR) alpha, beta, and gamma were initially discovered in fish and shown to have a role in oocyte maturation. The predicted multiple membrane spanning domain structure of the mPRs resembles that of heptahelical G-protein-coupled receptors. Phylogenetic analysis indicated that the mPRs belong to the large progestin and adiponectin Q receptor (PAQR) gene family. Based on the reported expression of the 3 mPRs in hormone-responsive ...
Source: Human Pathology - May 12, 2008 Category: Pathology Authors: Romero-Sánchez M, Peiper SC, Evans B, Wang Z, Catasús L, Ribe A, Prat J, Giri JG Tags: Hum Pathol Source Type: journals

Body size and risk of epithelial ovarian and related cancers: A population-based case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was pos...
Source: International Journal of Cancer - April 30, 2008 Category: Cancer & Oncology Authors: Catherine M. Olsen, Christina M. Nagle, David C. Whiteman, David M. Purdie, Adèle C. Green, Penelope M. Webb, Australian Cancer Study (Ovarian Cancer) and Australian Ovarian Cancer Study Group Source Type: journals

[My approach] My approach to and thoughts on the typing of ovarian carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each with a different underlying pathogenesis and natural behaviour. Accurate classification of ovarian carcinomas is important since each type may be associated with a different behaviour, natural history and outcome. Precise classification is also critical to determine whether alternative therapeutic strategies are appropriate for different tumour types. Previous studies have shown significant interobserver variation in the typing of ovarian carcinomas. There are several areas where there are particular difficulties; these include the dist...
Source: Journal of Clinical Pathology - January 25, 2008 Category: Pathology Authors: McCluggage, W G Tags: My approach Source Type: journals

Atypical endometriosis: a clinicopathologic study of 163 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion AEM lesions have some features which are similar and also differ from both of the tumor and EM. AEMs have a relative higher potential for tumorigenesis and canceration, especially for ovarian cancer. The process of damage, repair, and scarring in EM foci over a long period may play a role in the development of EM into AEM and eventally into tumor formation. Content Type Journal ArticleDOI 10.1007/s11805-007-0405-0Authors Donghui Guo, Tianjin Central Obstetrics & Gynecology Hospital Department of Pathology Tianjin 300052 ChinaShujie Pang, Tianjin Central Obstetrics & Gynecology Hospital Depa...
Source: Chinese Journal of Clinical Oncology - January 14, 2008 Category: Cancer & Oncology Tags: Chinese Journal of Clinical Oncology Source Type: journals

Overexpression of mammaglobin B in epithelial ovarian carcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Mammaglobin B gene is highly expressed in EOC and may represent a novel molecular marker for multiple histological types of ovarian cancer. Additional studies to evaluate the clinical utility of Mammaglobin B as a diagnostic and/or therapeutic target in ovarian cancer are warranted. PMID: 17343903 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 5, 2007 Category: Cancer & Oncology Authors: Tassi RA, Bignotti E, Rossi E, Falchetti M, Donzelli C, Calza S, Ravaggi A, Bandiera E, Pecorelli S, Santin AD Tags: Gynecol Oncol Source Type: journals

Mitochondrial DNA sequence variants in epithelial ovarian tumor subtypes and stagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings indicate that certain mtDNA mutations can reliably distinguish the different histologic subtypes of epithelial ovarian tumors. In addition, these data raise the possibility that certain mtDNA mutations may be useful biomarkers for predicting tumor aggressiveness and may play a potential role in tumorigenesis. (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - January 26, 2007 Category: Cancer & Oncology Authors: Felix O Aikhionbare, Sharifeh Mehrabi, K Kumaresan, Mojgan Zavareh, Moshood Olatinwo, Kunle Odunsi and Edward Partridge Source Type: journals

Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study were to analyze the real role that these pathways play in ovarian cancer, to correlate them with clinicopathologic characteristics, and to identify the factors that transmit individual proliferation signals and are associated with pathologic grade and prognosis, regardless specific oncogenic alterations upstream.One hundred twenty-nine ovarian epithelial tumors were studied, including 20 serous cystadenomas, 7 mucinous cystadenomas, 11 serous borderline tumors, 16 mucinous borderline tumors, 29 serous carcinomas, 16 endometrioid carcinomas, 15 clear cell carcinomas, and 15 mucinous carcinomas. ...
Source: Cancer - September 19, 2006 Category: Cancer & Oncology Authors: Josep Castellvi, Angel Garcia, Federico Rojo, Carmen Ruiz-Marcellan, Antonio Gil, Jose Baselga, Santiago Ramon y Cajal Source Type: journals