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Breastfeeding and risk of epithelial ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A long total duration of breastfeeding appears to be associated with a substantial reduction in the overall risk of ovarian cancer, independent of the decrease in risk due to childbirth, but this may vary according to histological subtype. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9440-xAuthors Susan J. Jordan, The University of Queensland School of Population Health Public Health Building, Herston Rd Herston, Brisbane 4006 AustraliaVictor Siskind, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaAdèle C ...
Source: Cancer Causes and Control - September 24, 2009 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: journals

Clinical Significance of Frozen Section Analysis During Resection of Intraductal Papillary Mucinous Neoplasm: Should a Positive Pancreatic Margin for Adenoma or Borderline Lesion Be Resected Additionally?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presence of adenoma or borderline lesion at the pancreatic margin does not always warrant further resection because of the low recurrence rate in the remnant pancreas. Recurrence after intraductal papillary mucinous neoplasm resection is influenced primarily by the presence and extent of invasive cancer rather than the status of the pancreatic margin. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - September 21, 2009 Category: Surgery Authors: Satoshi Nara, Kazuaki Shimada, Yoshihiro Sakamoto, Minoru Esaki, Tomoo Kosuge, Nobuyoshi Hiraoka Tags: Original Scientific Articles Source Type: journals

Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidneyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a mucinous borderline tumor arising from a mixed epithelial and stromal tumor of left kidney (MESTK). The patient was an 82-year-old woman who presented with gross hematuria and recurrent urinary tract infection for years. The patient had a cytoscopy with a retrograde pyelogram, which indicated a dilated left kidney with a central mass lesion. Subsequently, she underwent a radical left nephrectomy. Cross-sections of left kidney showed a 4.5 × 3.5 × 1.5 cm ill-defined cystic lesion with mucinous and solid areas. Histologic sections of the lesion showed numerous variable-sized dilated cysts with ...
Source: Virchows Archiv - September 16, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms: real association or just a coincidence?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association. PMID: 19734627 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Gill KR, Scimeca D, Stauffer J, Krishna M, Woodward TA, Jamil LH, Wallace MB, Nguyen JH, Raimondo M Tags: JOP Source Type: journals

Pseudomyxoma peritonei associated with primary mucinous borderline tumor of the renal pelvicalyceal system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary mucinous cystic neoplasms are extraordinarily rare tumors of the kidney. Herein, we present a case of a 52-year-old man who presented with painless hematuria and mucusuria. The nephrectomy showed a markedly enlarged kidney replaced by a large cystic mass filled with mucin and with almost complete destruction of the renal parenchyma. Histologically, the mass was lined primarily by simple mucinous epithelium and showed foci of adenomatous (borderline) change with focal areas exhibiting intraepithelial carcinoma. No invasion was documented after extensive sampling of the tumor. A pathologic diagnosis of intraepith...
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Rao P, Pinheiro N, Franco M, Ra S, Costa H, Manzano J, Paner GP, Silva EG, Amin MB Tags: Arch Pathol Lab Med Source Type: journals

[Claudin expression in different pancreatic cancers and its significance in differential diagnostics.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.)...
Source: Magyar Onkologia - August 31, 2009 Category: Cancer & Oncology Authors: Borka K Tags: Magy Onkol Source Type: journals

Clinical impact of under-diagnosis by frozen section examination is minimal in borderline ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The under-diagnosis by frozen section examination did not compromise the outcome in patients with BOTs, although under-diagnosis was associated with more conservative surgery. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - August 11, 2009 Category: Cancer & Oncology Authors: K. Kim, H.H. Chung, J.W. Kim, N.H. Park, Y.S. Song, S.B. Kang Tags: Original Articles Source Type: journals

Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sertoli-Leydig cell tumor (SLCT) is a rare tumor involving the ovary. Approximately 20% of SLCT are associated with heterologous elements that are either of endodermal or mesodermal origin. The gastrointestinal-type epithelium is the most commonly described endodermal heterologous element. SLCT with benign and borderline mucinous neoplasm has been reported in the literature. However, SLCT with mucinous adenocarcinoma as heterologous element has been rarely documented. Herein, we describe a rare case of intermediately differentiated Sertoli-Leydig cell tumor with mucinous adenocarcinoma as the heterologous element in a ...
Source: Pathology, Research and Practice - August 9, 2009 Category: Pathology Authors: Virk R, Lu D Tags: Pathol Res Pract Source Type: journals

Main Pancreatic Duct Intraductal Papillary Mucinous Neoplasms: Accuracy of MR Imaging in Differentiation between Benign and Malignant Tumors Compared with Histopathologic Analysis [Gastrointestinal Imaging]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Duct wall nodules and enhancement of the MPD walls are signs of malignant MPD or mixed type IPMNs. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/radiol.2531080604/DC1 © RSNA, 2009 (Source: Continuous Publishing articles)
Source: Continuous Publishing articles - July 30, 2009 Category: Radiology Authors: Manfredi, R., Graziani, R., Motton, M., Mantovani, W., Baltieri, S., Tognolini, A., Crippa, S., Capelli, P., Salvia, R., Pozzi Mucelli, R. Tags: Gastrointestinal Imaging Source Type: journals

Main Pancreatic Duct Intraductal Papillary Mucinous Neoplasms: Accuracy of MR Imaging in Differentiation between Benign and Malignant Tumors Compared with Histopathologic Analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Duct wall nodules and enhancement of the MPD walls are signs of malignant MPD or mixed type IPMNs. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/radiol.2531080604/DC1 (c) RSNA, 2009. PMID: 19703865 [PubMed - as supplied by publisher] (Source: Radiology)
Source: Radiology - July 30, 2009 Category: Radiology Authors: Manfredi R, Graziani R, Motton M, Mantovani W, Baltieri S, Tognolini A, Crippa S, Capelli P, Salvia R, Pozzi Mucelli R Tags: Radiology Source Type: journals

Borderline-like Mucinous Tumor Arising in Mature Cystic Teratoma of the Ovary Associated With Pseudomyxoma Peritonei.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 376DOI: 10.1097/PGP.0b013e318191e766Authors: Hwang, Jong Ha MD; So, Kyeong-A MD; Modi, Gayatri MD; Lee, Jae Kwan PhD; Lee, Nak Woo PhD; Lee, Kyu Wan PhD; Kim, Insun PhD (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - June 26, 2009 Category: Pathology Tags: Abstract HTML PDF (507 K) Source Type: journals

[Diagnostic problems of ovarian mucinous borderline tumors.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is go...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Vereczkey I, Tóth E, Orosz Z Tags: Magy Onkol Source Type: journals

[Diagnostic problems of ovarian mucinous borderline tumors]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is go...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Vereczkey I, Tóth E, Orosz Z Tags: Magy Onkol Source Type: journals

Mucinous cystic neoplasms of the mesentery: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Mucinous cystic neoplasms of the mesentery present almost exclusively in women and must be considered in the differential diagnosis of mesenteric tumors. Only full histological examination of a mucinous cystic neoplasm can exclude a borderline or malignant component. An updated classification of mesenteric cysts and cystic tumors is proposed. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - May 19, 2009 Category: Cancer & Oncology Authors: Georgios Metaxas, Athanasios Tangalos, Polixeni Pappa and Irene Papageorgiou Source Type: journals

Clinical fate of branch duct and mixed forms of intraductal papillary mucinous neoplasia of the pancreasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with the mixed form of IPMN as well as with symptomatic branch duct IPMN should require pancreatic resection because of symptoms and the risk for malignancy. In silent branch duct IPMN without radiological signs of malignancy, a non-operative watch-and-wait strategy can be discussed. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - May 19, 2009 Category: Gastroenterology Authors: Barbara Bournet, Sylvain Kirzin, Nicolas Carrère, Guillaume Portier, Philippe Otal, Janick Selves, Carole Musso, Bertrand Suc, Jacques Moreau, Gilles Fourtanier, Bernard Pradère, Franck Lazorthes, Jean Escourrou, Louis Buscail Source Type: journals

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - May 18, 2009 Category: Pathology Authors: Jin Hyung Heo, Kwang Il Kim, Sun Young Lee, Tae Heon Kim, Haeyoun Kang, Hee Jung An Source Type: journals

A unique benign mucinous cystadenoma of the retroperitoneum: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present here the curious case of a 37-year-old woman with two large, fast growing, cystic, benign, primary retroperitoneal mucinous cystadenomas treated definitively by local resection. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1118-9Authors Elliot B. Tapper, Emory University School of Medicine 1293 University Dr Atlanta GA 30306 USAAdam B. Shrewsberry, Emory University School of Medicine 1293 University Dr Atlanta GA 30306 USAGabriella Oprea, Emory University School of Medicine 1293 University Dr Atlanta GA 30306 USABhagirath Majmudar, Emory University School of Medicine 1293 Universi...
Source: Archives of Gynecology and Obstetrics - May 16, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors. The method focused on immunostaining of paraffin-embedded tumor samples. Almost all macrophages infiltrating tumor...
Source: Pathology International - April 21, 2009 Category: Pathology Authors: Kyoko Kawamura, Yoshihiro Komohara, Kiyomi Takaishi, Hidetaka Katabuchi, Motohiro Takeya Tags: Original Articles Source Type: journals

KRAS mutation analysis in ovarian samples using a high sensitivity biochip assayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: KRAS mutation is a common event in ovarian cancer primarily in carcinomas of lower grade, lower FIGO stage, and mucinous histotype. The KRAS mutational status is no prognostic factor for patients treated with standard therapy. However, in line with experience from colorectal cancer and non-small-cell-lung cancer (NSCLC), it may be important in predicting response to EGFR-targeted therapies. (Source: BMC Cancer)
Source: BMC Cancer - April 9, 2009 Category: Cancer & Oncology Authors: Veronika Auner, Gernot Kriegshauser, Dan Tong, Reinhard Horvat, Alexander Reinthaller, Alexander Mustea and Robert Zeillinger Source Type: journals

Biliary intraductal papillary mucinous neoplasia: three case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present herein three cases diagnosed with the clinical and pathological findings of a new entity in the literature, b-IPMN, and we discuss the macroscopic, histological, and immunohistochemical features. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00428-009-0767-1Authors Banu Yaman, University of Ege Department of Pathology, Faculty of Medicine Izmir TurkeyDeniz Nart, University of Ege Department of Pathology, Faculty of Medicine Izmir TurkeyFunda Yilmaz, University of Ege Department of Pathology, Faculty of Medicine Izmir TurkeyAhmet Coker, University of Ege Department of General Surgery, Faculty...
Source: Virchows Archiv - April 5, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION:: A simple increase in cyst size is not a reliable predictor of malignancy. Observation is recommended for patients with a BD-IPMN smaller than 30 mm showing no suspicious features on imaging. Copyright (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 19283746 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - March 12, 2009 Category: Surgery Authors: Woo SM, Ryu JK, Lee SH, Yoon WJ, Kim YT, Yoon YB Tags: Br J Surg Source Type: journals

Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated whether these recommendations could be validated in a single-centre experience of BD-IPMNs.Some 190 patients with radiological imaging or histological findings consistent with BD-IPMN were enrolled between 1998 and 2005. Those with less than 6 months' follow-up and no histological confirmation were excluded.BD-IPMN was diagnosed by computed tomography and pancreatography in 105 patients and pathologically in 85. Eighteen patients had adenoma, 53 borderline malignancy, five carcinoma in situ and nine invasive carcinoma. Findings associated with malignancy were the presence of radiologically suspiciou...
Source: British Journal of Surgery - March 12, 2009 Category: Surgery Authors: S. M. Woo, J. K. Ryu, S. H. Lee, W. J. Yoon, Y.-T. Kim, Y. B. Yoon Tags: Original Articles Source Type: journals

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 9, 2009 Category: Cancer & Oncology Authors: Shimada M, Kigawa J, Ohishi Y, Yasuda M, Suzuki M, Hiura M, Nishimura R, Tabata T, Sugiyama T, Kaku T Tags: Gynecol Oncol Source Type: journals

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinou...
Source: Human Pathology - March 9, 2009 Category: Pathology Authors: Masafumi Yasunaga, Yoshihiro Ohishi, Yoshinao Oda, Munechika Misumi, Atsuko Iwasa, Shuichi Kurihara, Izumi Nishimura, Emi Okuma, Hiroaki Kobayashi, Norio Wake, Masazumi Tsuneyoshi Tags: Original Contributions Source Type: journals

MRI appearances of borderline ovarian tumours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review was performed to describe the range of magnetic resonance imaging (MRI) appearances of borderline ovarian tumours. The MRI findings in 26 patients with 31 borderline ovarian tumours (mean age: 40.1 years, range: 14-85 years) were retrospectively reviewed. For each tumour, site, size, MRI characteristics, and enhancement following gadolinium administration were recorded. There were 20 serous and 11 mucinous borderline ovarian subtypes. Nine of 26 patients demonstrated bilateral disease on MRI; synchronous contralateral ovarian disease included three benign, five serous borderline, and one serous invasive tum...
Source: Clinical Radiology - March 8, 2009 Category: Radiology Authors: Bent CL, Sahdev A, Rockall AG, Singh N, Sohaib SA, Reznek RH Tags: Clin Radiol Source Type: journals

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous bor...
Source: Human Pathology - March 6, 2009 Category: Pathology Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Tags: Hum Pathol Source Type: journals

Choroidal eye metastases from (recurrent) primary peritoneal carcinoma: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High index of suspicion is warranted when patients with history of primary peritoneal carcinoma present with visual complaints in order to treat and/or relieve symptomatology from metastatic eye disease. (Source: International Seminars in Surgical Oncology)
Source: International Seminars in Surgical Oncology - January 20, 2009 Category: Surgery Authors: Nikolaos Thomakos, Khandra Galaal, Georgios Georgopoulos, Lakshmi Nagaraju, Dianne Hemming and Raj Naik Source Type: journals

[Computed tomography of pancreatic tumors.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Computed tomography (CT) and in particular multi-detector row computed tomography (MDCT), also known as multislice CT (MSCT), is ideally suited for detecting pancreatic tumors because of the high spatial resolution.The method of choice is hydro-CT which involves distension of the stomach and duodenum by administration of 1-1.5 l water as a negative contrast medium under medically induced hypotension by administration of buscopan. The patient is laid on the right side at an angle of 30-45 degrees in order to obtain an artefact-free image of the close anatomical relationship around the pancreas head. In addition, curved ...
Source: Der Radiologe - January 11, 2009 Category: Radiology Authors: Grenacher L, Klauß M Tags: Radiologe Source Type: journals

Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is a close association between SMMN-FGT and LEGH/PGM. Microinvasion and positive peritoneal cytology may not have an influence on outcome. PMID: 19207943 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - January 1, 2009 Category: Pathology Authors: Mikami Y, Kiyokawa T, Sasajima Y, Teramoto N, Wakasa T, Wakasa K, Hata S Tags: Histopathology Source Type: journals

Accuracy of frozen section diagnosis in ovarian masses: experience at a tertiary oncology centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Frozen section is a reliable method for surgical management of patients with adnexal masses. Gross examination and clinical data are two valuable parts of intraoperative consultation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0899-6Authors Azadeh Rakhshan, Shohada Hospital, Shaheed Beheshti University of Medical Sciences Department of Pathology Tehran IranHanieh Zham, Shohada Hospital, Shaheed Beheshti University of Medical Sciences Department of Pathology Tehran IranMehdi Kazempour, Masih Daneshvari Hospital, Shaheed Beheshti University of Medical Sciences ...
Source: Archives of Gynecology and Obstetrics - December 31, 2008 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

LIM only 4 is overexpressed in late stage pancreas cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pancreatic carcinomas (both IDC and IPMC) expressed significantly higher levels of LMO4 mRNA than did normal ductal epithelia, PanIN-1B, PanIN-2, IPMA and IPMB. These results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - December 22, 2008 Category: Cancer & Oncology Authors: Jun Yu, Kenoki Ohuchida, Kohei Nakata, Kazuhiro Mizumoto, Lin Cui, Hayato Fujita, Hiroshi Yamaguchi, Takuya Egami, Hidehisa Kitada and Masao Tanaka Source Type: journals

[Differentiated therapy for intraductal papillary mucinous neoplasms.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are of increasing interest in the field of pancreatic surgery ever since their first description as an individual pancreatic tumor entity in 1982. The decision for surgical or conservative management is based on the adenoma-carcinoma sequence and the differentiation into main-duct or branch-duct IPMN. Invasive IPMN forms (carcinoma in situ and invasive carcinoma) and in particular noninvasive IPMNs (adenoma and borderline tumors) reveal significantly better survival rates than ductal adenocarcinoma of the pancreas. PMID: 19082569 [PubMed - as supplied ...
Source: Der Chirurg - December 12, 2008 Category: Surgery Authors: Wente MN, Schmied BM, Schmidt J, Büchler MW Tags: Chirurg Source Type: journals

Analysis of gene expression in early-stage ovarian cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Specific molecular signatures define different histotypes and prognosis of stage I ovarian cancer. Mucinous and clear cells histotypes can be distinguished from the others regardless of tumor grade. Cyclin E and minichromosome maintenance protein 5, whose expression was found previously to be related to a bad prognosis of advanced ovarian cancer, appear to be potential prognostic markers in stage I ovarian cancer too, independent of other pathologic and clinical variables. PMID: 19047114 [PubMed - in process] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - December 1, 2008 Category: Cancer & Oncology Authors: Marchini S, Mariani P, Chiorino G, Marrazzo E, Bonomi R, Fruscio R, Clivio L, Garbi A, Torri V, Cinquini M, Dell'anna T, Apolone G, Broggini M, D'Incalci M Tags: Clin Cancer Res Source Type: journals

Predictive value of needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results show that approximately one-fifth of NCB of screen-detected breast lesions classified as B3 are malignant on excision, and the likelihood of malignancy varies substantially between different histological subtypes. PMID: 19076681 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - December 1, 2008 Category: Pathology Authors: El-Sayed ME, Rakha EA, Reed J, Lee AH, Evans AJ, Ellis IO Tags: Histopathology Source Type: journals

[Cystic neoplasms of the pancreas. Diagnostic and therapeutic management.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Management of the cystic lesions of the pancreas is of interest to general and pancreatic surgeons and physicians of other disciplines: gastroenterology, internal medicine, endoscopy, radiology, pathology, etc. The majority of cystic lesions are inflammatory pseudo-cysts. Cystic neoplasms represents only 10% of cystic lesions of the pancreas and 1% of pancreatic tumours. Preoperative diagnosis is crucial given the differences in natural history of the spectrum of benign, malignant, and borderline lesions. Serous cystadenoma is a benign lesion that requires non-surgical management if there are no symptoms. Mucinous neop...
Source: Cirugia eEspanola - December 1, 2008 Category: Surgery Authors: Jorba R, Fabregat J, Borobia FG, Busquets J, Ramos E, Torras J, Lladó L, Valls C, Serrano T, Rafecas A Tags: Cir Esp Source Type: journals

Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results support the differential expression in MMPs and TIMPs of ovarian tumors according to serous or mucinous histology. PMID: 19020757 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 23, 2008 Category: Cancer & Oncology Authors: Brun JL, Cortez A, Commo F, Uzan S, Rouzier R, Daraï E Tags: Int J Oncol Source Type: journals

Correlation between CT patterns and pathological classification of intraductal papillary mucinous neoplasm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The three CT types of IPMN well correlated with the pathologic classification, which is helpful for analyzing CT manifestations and improving the accuracy of diagnosis. MPD dilation is usually larger than CBD dilation in IPMN patients, which is also helpful in the diagnosis and differential diagnosis of IPMN in the context of other related findings. PMID: 19008065 [PubMed - as supplied by publisher] (Source: European Journal of Radiology)
Source: European Journal of Radiology - November 11, 2008 Category: Radiology Authors: Zhang J, Wang PJ, Yuan XD Tags: Eur J Radiol Source Type: journals

Serous and seromucinous infantile ovarian cystadenomas-A study of 42 cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The rarity of infantile ovarian cystadenoma (CA) accounts for the very little knowledge about their behaviour. The aim of this retrospective study is to highlight the modes of presentation and to evaluate the treatments and the recurrence risks of these benign tumours. Relation to adult epithelial ovarian tumours is discussed. The medical records and imaging studies of 42 CA in 31 children less than 16 years of age operated at our institution between 1985 and 2003 were retrospectively evaluated. Mean age of first surgery was 11 and 5 years. 7/31 (22, 6%) girls presented with a bilateral CA, four of them were synchronou...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 7, 2008 Category: OBGYN Authors: Massicot R, Rousseau V, Darwish AA, Sauvat F, Jaubert F, Nihoul-Fékété C Tags: Eur J Obstet Gynecol Reprod Biol Source Type: journals

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - November 4, 2008 Category: Pathology Authors: Sung Ho Hwang, Sang Jae Noh, Hyong Jong Kwak, Kyung Ryoul Kim, Ho Sung Park, Woo Sung Moon, Myoung Ja Chung, Keun Sang Kwon, Kwan Sik Kim, Kyu Yun Jang Source Type: journals

MSCT and MRCP features of intraductal papillary mucinous tumor of the pancreasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The MSCT and MRCP features of IPMT are somewhat characteristic, and the correct diagnosis can be made with the combination of clinical features. Diameter of branch duct ≥ 3 cm with multiple or large mural nodules, or severe dilated main duct indicates the probability of malignant IPMT. Content Type Journal ArticleDOI 10.1007/s10330-008-0106-zAuthors Bin Yang, Hangzhou First People’s Hospital Department of Radiology Hangzhou 310006 ChinaWenhui Chen, Hangzhou First People’s Hospital Department of Radiology Hangzhou 310006 ChinaXiaofeng Zhang, Hangzhou First People’s Hospital Departmen...
Source: The Chinese-German Journal of Clinical Oncology - November 1, 2008 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Immunohistochemical expression of GCIP in breast carcinoma: relationship with tumour grade, disease-free survival, mucinous differentiation and response to chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The current data provide evidence that decreased expression of GCIP in vivo is present in human breast carcinoma and indicate that GCIP is a potential indicator of good prognosis. In patients receiving neoadjuvant chemotherapy, it may also have predictive value for the chemotherapeutic response. PMID: 18983464 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - November 1, 2008 Category: Pathology Authors: Chen WC, Su PF, Jin YT, Chang MC, Chang TW Tags: Histopathology Source Type: journals

Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saita...
Source: Archives of Gynecology and Obstetrics - October 21, 2008 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Expression of hepatocyte nuclear factor 4α in primary ovarian mucinous tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatocyte nuclear factor 4[alpha] (HNF4[alpha]) is a member of the nuclear receptor superfamily and is expressed in several endodermal tissues. The aim of the present study was to examine the expression of HNF4[alpha] on ovarian epithelial tumors with immunocytochemistry and immunohistochemistry using mAbs recognizing P1 and P2 promoter-driven HNF4[alpha]. Ovarian mucinous adenoma, mucinous tumors of borderline malignancy, and mucinous adenocarcinoma had positive nuclear staining for HNF4[alpha] (41/45, 91%). One-third (34%) of mucinous tumors had P1-positive staining and most had P1/P2-positive staining (93%). MUC2- and ...
Source: Pathology International - October 11, 2008 Category: Pathology Authors: Mika Sugai, Hajime Umezu, Takashi Yamamoto, Shuying Jiang, Hiroko Iwanari, Toshiya Tanaka, Takao Hamakubo, Tatsuhiko Kodama, Makoto Naito Tags: Original Articles Source Type: journals

Identical twins with ovarian endometriosis and mucinous borderline tumor: an unusual associationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Ovarian tumors present in monozygotic twins may not always be of the same histologic type. (Source: Fertility and Sterility)
Source: Fertility and Sterility - October 1, 2008 Category: Reproduction Medicine Authors: Ma-Lee Ko, Hun-Shan Pan Tags: Case report summaries Source Type: journals

Diverse histologic appearances in pulmonary mucinous cystic neoplasia: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This case highlights the continuous spectrum of pulmonary mucinous cystic neoplasia from benign mucinous cystadenoma to malignant mucinous cystadenocarcinoma, and the probable existence of a 'borderline' mucinous cystic tumor. Although molecular data are lacking to substantiate progression from benign to malignant in these neoplasms, the importance of recognizing the morphologic continuum lies in alerting pathologists to thoroughly examine specimens to rule out invasive foci in tumors with 'borderline' morphology. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 29, 2008 Category: Journals (General) Authors: Christine Wynveen, Behnaz Behmaram, George Haasler and Nagarjun Rao Source Type: journals

Loss of heterozygosity on chromosome 17p13.3 in ovarian cancer and cervical cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results show that LOH on 17p13.3 is associated with ovarian cancer and cervical cancer, suggesting that detection of LOH on 17p13.3 may be helpful to understand the molecular pathogenesis of ovarian cancer and cervical cancer. Content Type Journal ArticleDOI 10.1007/BF02962173Authors Guoling Zhang, Shanghai Medical University Department of Gynecology, Shanghai Cancer Hospital 200032 ShanghaiHuijian Yang, Shanghai Medical University Department of Gynecology, Shanghai Cancer Hospital 200032 ShanghaiKaili Xu, Shanghai Cancer Institute 200032 ShanghaiJin Zhou, Shanghai Cancer Institute 200032 ShanghaiRu...
Source: Chinese Journal of Cancer Research - September 28, 2008 Category: Cancer & Oncology Tags: Chinese Journal of Cancer Research Source Type: journals

Laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein: Report of three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Between March 2003 and March 2007, three patients with benign pancreatic tumors underwent a planned laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein. Four trocars were placed, and an endoscopic linear stapler was used to transect of the pancreas. The perioperative data and surgical outcomes were examined. This procedure was successfully completed in three patients. The mean operative time was 158.3 min, with mean blood loss of 14.7 ml. The postoperative pathological diagnoses included one insulinoma, one solid pseudopapillary tumor, and one intrad...
Source: Surgery Today - September 27, 2008 Category: Surgery Tags: Surgery Today Source Type: journals

Extrapancreatic Malignancies in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas: Prevalence, Associated Factors, and Comparison with Patients with Other Pancreatic Cystic NeoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The EPM prevalence of IPMN patients was 33.8%. Advanced age at IPMN diagnosis was the only factor significantly associated with EPMs in our IPMN cohort. In our PCN cohort, advanced age at PCN diagnosis was associated with malignant PCN and IPMN showed a borderline positive association with EPM. Content Type Journal ArticleCategory Hepatobiliary and Pancreatic TumorsDOI 10.1245/s10434-008-0143-4Authors Won Jae Yoon, Seoul National University College of Medicine Division of Gastroenterology, Department of Internal Medicine 28 Yeongon-dong, Jongno-gu Seoul 110-744 KoreaJi Kon Ryu, Seoul Nation...
Source: Annals of Surgical Oncology - September 11, 2008 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Accuracy of intraoperative frozen section in the diagnosis of ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Frozen section appears to be an accurate technique for the histopathological diagnosis of ovarian tumours. Some limitations were observed among borderline and mucinous tumours. This emphasises the great value of frozen section in the diagnosis of ovarian tumours. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - August 29, 2008 Category: OBGYN Authors: Fariba YARANDI, Z. EFTEKHAR, Narges IZADI-MOOD, Hadi SHOJAEI Tags: ORIGINAL ARTICLES Source Type: journals