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Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Women may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are a...
Source: Diagnostic Histopathology - October 12, 2009 Category: Pathology Authors: Ui-Soon Khoo, Dan-Hua Shen, Richard Wing-Cheuk Wong, Annie Nga-Yin Cheung Tags: Mini-Symposium: Pathology of the Uterus and Fallopian Tube Source Type: journals

[Peritoneal serous borderline tumor discovered during a cesarean section. A case report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During a caesarean section performed in a 36-year-old woman, we discovered small granulations on the pelvic peritoneum. Biopsies were performed. The diagnosis of primitive borderline serous tumor was confirmed by pathologists. The patient was operated twice: once for diagnostic evaluation, and again six months later. A radical gesture was then decided for therapeutic purposes. The optimal attitude regarding these borderline peritoneal tumors in young women remains difficult and requires a multidisciplinary workout between pathologists and surgeons. PMID: 19819645 [PubMed - as supplied by publisher] (Source: Journal...
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - October 8, 2009 Category: OBGYN Authors: Raiga J, Ben Abdelkrim S, Dupré F, Treisser A Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: journals

Breastfeeding and risk of epithelial ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A long total duration of breastfeeding appears to be associated with a substantial reduction in the overall risk of ovarian cancer, independent of the decrease in risk due to childbirth, but this may vary according to histological subtype. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9440-xAuthors Susan J. Jordan, The University of Queensland School of Population Health Public Health Building, Herston Rd Herston, Brisbane 4006 AustraliaVictor Siskind, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaAdèle C ...
Source: Cancer Causes and Control - September 24, 2009 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: journals

Conservative resection for benign tumors of the proximal pancreas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CR is a safe and effective procedure for patients with benign tumors in the proximal pancreas, with careful CCI-PJ and postoperative MCCL. PMID: 19705501 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 27, 2009 Category: Gastroenterology Authors: Huang H, Dong X, Gao SL, Wu YL Tags: World J Gastroenterol Source Type: journals

Ovarian Low-grade and High-grade Serous Carcinoma: Pathogenesis, Clinicopathologic and Molecular Biologic Features, and Diagnostic ProblemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier system in which tumors are subdivided into low grade and high grade has been proposed. This approach is simplistic, reproducible, and based on biologic evidence indicating that both tumors develop via different pathways. Low-grade serous carcinomas exhibit low-grade nuclei with infrequent mitotic figures. They evolve from adenofibromas or borderline tumors, have frequent mutations of the KRAS, BRAF, or ERBB2 genes, and lack TP53 mutations (Type I pathway). The progression to invasive carcinoma is a slow step-wise process. Low-grade tumors ...
Source: Advances in Anatomic Pathology - August 26, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of advanced-stage borderline ovarian tumors (with noninvasive implants) but the recurrence rate is high. Nevertheless, this high rate has no impact on survival. Conservative surgery can be proposed to patients with a borderline tumor of the ovary and noninvasive peritoneal implants. Should infertility persist following treatment of the borderline tumor, an in vitro fertilization procedure can be cautiously proposed. PMID: 19608617 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 15, 2009 Category: Cancer & Oncology Authors: Uzan C, Kane A, Rey A, Gouy S, Duvillard P, Morice P Tags: Ann Oncol Source Type: journals

Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The existence of sarcomatous nodules combined with the SLMN necessitates a careful histologic analysis for treatment and the determination of prognosis. However, too few cases of mixed type mural nodules have been published to warrant a conclusion regarding their prognosis. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1180-3Authors Tayfun Gungor, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Gynecologic Oncology Department Ankara TurkeyS. Ozlem Altınkaya, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Gyn...
Source: Archives of Gynecology and Obstetrics - July 14, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Clinicopathological significance of DEK overexpression in serous ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To investigate the significance of DEK protein expression in ovarian lesions, a total of 113 ovarian serous tumors, including 62 serous cystadenocarcinomas and 19 serous borderline tumors, were studied on immunohistochemistry. For comparison, 32 benign serous tumors, including 12 serous papillary cystadenomas, 10 serous cystadenomas, and 10 serous surface papillomas, were also included. DEK was positive in 93.5% of serous cystadenocarcinomas (58/62), 63.2% of serous borderline tumors (12/19), and weakly positive in 15.6% of benign serous tumors (5/32). The strong positive signal was detected only in serous adenocarcinomas ...
Source: Pathology International - June 21, 2009 Category: Pathology Authors: Songying Han, Yanhua Xuan, Shuangping Liu, Meihua Zhang, Dongzhu Jin, Renshun Jin, Zhenhua Lin Tags: Original Articles Source Type: journals

The expression of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor protein and mRNA in benign, borderline and malignant ovarian neoplasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the expression patterns of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor (MIS/AMHRII) and mRNA in various types of ovarian neoplasia and evaluated the clinical significance of MIS/AMH as a biological response modifier for MIS/AMHR-positive tumors. Reverse transcriptase polymerase chain reaction was used to detect MIS/AMHRII mRNA expression and in situ hybridization and immunohistochemistry were used to localize MIS/AMHRII mRNA and protein expression. The degree of expression was scored from 0 (no staining) to 3 (strong staining). There was no significant difference...
Source: International Journal of Oncology - May 31, 2009 Category: Cancer & Oncology Authors: Song JY, Chen KY, Kim SY, Kim MR, Ryu KS, Cha JH, Kang CS, MacLaughlin DT, Kim JH Tags: Int J Oncol Source Type: journals

Prognostic factors in patients with ovarian serous low malignant potential (borderline) tumors with peritoneal implants.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to determine prognostic factors in a large series of patients with stage II or III serous low malignant potential ovarian tumor (LMPOT) and peritoneal implants. Methods. Patients with a serous LMPOT and peritoneal implants treated at or referred to our institution were retrospectively reviewed. The slides of ovarian tumors and peritoneal implants were reviewed by the same pathologist. Results. From 1969 to 2006, 168 patients were reviewed, 21 of whom had invasive implants. Tumors exhibited a micropapillary pattern in 56 patients. Adjuvant treatment had been administered to 61 patients. The m...
Source: The Oncologist - May 31, 2009 Category: Cancer & Oncology Authors: Kane A, Uzan C, Rey A, Gouy S, Camatte S, Pautier P, Lhommé C, Haie-Meder C, Duvillard P, Morice P Tags: Oncologist Source Type: journals

[Diagnostic problems of ovarian mucinous borderline tumors.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is go...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Vereczkey I, Tóth E, Orosz Z Tags: Magy Onkol Source Type: journals

[Diagnostic problems of ovarian mucinous borderline tumors]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is go...
Source: Magyar Onkologia - May 31, 2009 Category: Cancer & Oncology Authors: Vereczkey I, Tóth E, Orosz Z Tags: Magy Onkol Source Type: journals

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - May 18, 2009 Category: Pathology Authors: Jin Hyung Heo, Kwang Il Kim, Sun Young Lee, Tae Heon Kim, Haeyoun Kang, Hee Jung An Source Type: journals

Expression of Hyaluronan Synthases (HAS1-3) and Hyaluronidases (HYAL1-2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan ContentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results indicate that in serous epithelial ovarian malignancies HAS expression is not consistently elevated but HYAL1 expression is significantly reduced and correlates with the accumulation of hyaluronan. (Source: BMC Cancer)
Source: BMC Cancer - May 12, 2009 Category: Cancer & Oncology Authors: Timo K Nykopp, Kirsi Rilla, Reijo Sironen, Markku I Tammi, Raija H Tammi, Kirsi Hamalainen, Anna-Mari Heikkinen, Marja Komulainen, Veli-Matti Kosma and Maarit Anttila Source Type: journals

Gross genomic alterations differ between serous borderline tumors and serous adenocarcinomas—an image cytometric DNA ploidy analysis of 307 cases with histogenetic implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Our objective was to study the gross genomic alterations in serous borderline tumors and serous adenocarcinomas of the ovary. A retrospective analysis of 245 serous borderline tumors and 62 serous adenocarcinomas from 249 patients was performed using high-resolution image cytometric DNA ploidy analysis. DNA ploidy status, S-phase fraction, and DNA index were evaluated. The majority of serous borderline tumors were diploid (225/245 cases, 92%). The remaining 8% showed an aneuploid peak predominantly with DNA index of less than 1.4. Grades 2 and 3 serous adenocarcinomas were more often (80%) nondiploi...
Source: Virchows Archiv - May 7, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Results after conservative treatment of serous borderline tumours of the ovary with stromal microinvasion but without micropapillary pattern.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that conservative treatment of SBOT-SMI is safe. PMID: 19432576 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - April 30, 2009 Category: OBGYN Authors: Laurent I, Uzan C, Gouy S, Pautier P, Duvillard P, Morice P Tags: BJOG Source Type: journals

Analysis of DNA Copy Number Alterations in Ovarian Serous Tumors Identifies New Molecular Genetic Changes in Low-Grade and High-Grade CarcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian serous carcinoma, the most common and lethal type of ovarian cancer, is thought to develop from two distinct molecular pathways. High-grade (HG) serous carcinomas contain frequent TP53 mutations, whereas low-grade (LG) carcinomas arise from serous borderline tumors (SBT) and harbor mutations in KRAS/BRAF/ERBB2 pathway. However, the molecular alterations involved in the progression from SBT to LG carcinoma remain unknown. In addition, the extent of deletion of tumor suppressors in ovarian serous carcinomas has not been well studied. To further address these two issues, we assessed DNA copy number changes among affin...
Source: Cancer Research - April 30, 2009 Category: Cancer & Oncology Authors: Kuo, K.-T., Guan, B., Feng, Y., Mao, T.-L., Chen, X., Jinawath, N., Wang, Y., Kurman, R. J., Shih, I.-M., Wang, T.-L. Tags: Molecular Biology, Pathobiology, and Genetics Source Type: journals

Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors. The method focused on immunostaining of paraffin-embedded tumor samples. Almost all macrophages infiltrating tumor...
Source: Pathology International - April 21, 2009 Category: Pathology Authors: Kyoko Kawamura, Yoshihiro Komohara, Kiyomi Takaishi, Hidetaka Katabuchi, Motohiro Takeya Tags: Original Articles Source Type: journals

Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms because (1) clear cell carcinoma and serous borderline tumor do not coexist and (2) hobnail-like cells in clear cell carcinoma and serous borderline tumor are immunophenotypically distinct. Recognition of our conclusion may protect a patient with “conspicuous hobnail-like cells in serous borderline tumor” from an erroneous overdiagnosis of “concomitant clear cell carcinoma admixed with serous borderline tumor.” (Source: Human Pathology)
Source: Human Pathology - April 14, 2009 Category: Pathology Authors: Yoshihiro Ohishi, Yoshinao Oda, Shuichi Kurihara, Tsunehisa Kaku, Masafumi Yasunaga, Izumi Nishimura, Emi Okuma, Hiroaki Kobayashi, Norio Wake, Masazumi Tsuneyoshi Tags: Original Contributions Source Type: journals

Occurrence of Two Rare Malignant Neoplasms (Breast and Ovarian) in an Adolescent FemaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Phyllodes breast tumors, particularly malignant ones, are rare in adolescents. Tumor behavior does not correlate with histopathology. This case of an adolescent with a malignant phyllodes tumor, followed by the occurrence of a borderline ovarian tumor, also uncommon in adolescence, may shed light on our understanding of phyllodes and uncommon gynecologic malignancies in the young.Case: A-14 year-old Caucasian female underwent wide local excision of a 4-cm malignant phyllodes breast tumor. At 17 years of age she had excision of a serous borderline tumor of the ovary.Comments: The occurrence of two rare...
Source: Journal of Pediatric and Adolescent Gynecology - April 8, 2009 Category: OBGYN Authors: Yasmin Jayasinghe, Patricia S. Simmons Tags: Case Reports Source Type: journals

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 9, 2009 Category: Cancer & Oncology Authors: Shimada M, Kigawa J, Ohishi Y, Yasuda M, Suzuki M, Hiura M, Nishimura R, Tabata T, Sugiyama T, Kaku T Tags: Gynecol Oncol Source Type: journals

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinou...
Source: Human Pathology - March 9, 2009 Category: Pathology Authors: Masafumi Yasunaga, Yoshihiro Ohishi, Yoshinao Oda, Munechika Misumi, Atsuko Iwasa, Shuichi Kurihara, Izumi Nishimura, Emi Okuma, Hiroaki Kobayashi, Norio Wake, Masazumi Tsuneyoshi Tags: Original Contributions Source Type: journals

MRI appearances of borderline ovarian tumours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review was performed to describe the range of magnetic resonance imaging (MRI) appearances of borderline ovarian tumours. The MRI findings in 26 patients with 31 borderline ovarian tumours (mean age: 40.1 years, range: 14-85 years) were retrospectively reviewed. For each tumour, site, size, MRI characteristics, and enhancement following gadolinium administration were recorded. There were 20 serous and 11 mucinous borderline ovarian subtypes. Nine of 26 patients demonstrated bilateral disease on MRI; synchronous contralateral ovarian disease included three benign, five serous borderline, and one serous invasive tum...
Source: Clinical Radiology - March 8, 2009 Category: Radiology Authors: Bent CL, Sahdev A, Rockall AG, Singh N, Sohaib SA, Reznek RH Tags: Clin Radiol Source Type: journals

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous bor...
Source: Human Pathology - March 6, 2009 Category: Pathology Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Tags: Hum Pathol Source Type: journals

[Diagnostic difficulties of serous borderline tumors of the ovary.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 15-20% of all ovarian neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential). They represent a common diagnostic and treatment problem both for the pathologist and for clinicians. The borderline tumors occur most commonly in childbearing age, show an indolent course and have good prognosis but are resistant to the traditional chemotherapies. The serous borderline tumors are the most common types of borderline ovarian tumors and they can cause differential diagnostic problems even for the experienced pathologist. We studied 30 cases which were diagnosed in our institut...
Source: Magyar Onkologia - March 1, 2009 Category: Cancer & Oncology Authors: Vereczkey I, Tóth E, Orosz Z Tags: Magy Onkol Source Type: journals

Maspin overexpression correlates with positive response to primary chemotherapy in ovarian cancer patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Maspin is upregulated in borderline tumors and the early stages of ovarian carcinoma and then significantly downregulated with malignant transformation. High expression may paradoxically promote the invasion and metastasis of ovarian carcinomas. Our study revealed that maspin expression could play an important role in predicting the results of treatment of ovarian cancer patients. PMID: 19193429 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 2, 2009 Category: Cancer & Oncology Authors: Klasa-Mazurkiewicz D, Narkiewicz J, Milczek T, Lipińska B, Emerich J Tags: Gynecol Oncol Source Type: journals

Paratubal borderline serous tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Borderline fallopian tube or paratubal tumors are usually early stage at diagnosis and commonly present in the third decade with pain or are discovered on routine examination. Continued reporting of these tumors is essential to understanding the prognosis and treatment of this rare tumor. PMID: 19189870 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 1, 2009 Category: Cancer & Oncology Authors: Seamon LG, Holt CN, Suarez A, Richardson DL, Carlson MJ, O'Malley DM Tags: Gynecol Oncol Source Type: journals

A unique case of ovarian psammocarcinoma with mediastinal, pulmonary, subcutaneous, and omental metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of 45-year-old woman with ovarian psammocarcinoma who initially presented with a metastatic subcutaneous nodule, and was found to have pulmonary and mediastinal metastases. We believe this to be the first report of a psammocarcinoma with these metastases. Ovarian and peritoneal psammocarcinomas are quite rare, and because of this, knowledge of their behavior is limited. Although most seem to follow an indolent course similar to that of borderline lesions of the ovary, this case demonstrates that some of these tumors may be clinically aggressive with distant metastases. Content Type Journal ArticleC...
Source: Archives of Gynecology and Obstetrics - December 19, 2008 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

[Cystic neoplasms of the pancreas. Diagnostic and therapeutic management.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Management of the cystic lesions of the pancreas is of interest to general and pancreatic surgeons and physicians of other disciplines: gastroenterology, internal medicine, endoscopy, radiology, pathology, etc. The majority of cystic lesions are inflammatory pseudo-cysts. Cystic neoplasms represents only 10% of cystic lesions of the pancreas and 1% of pancreatic tumours. Preoperative diagnosis is crucial given the differences in natural history of the spectrum of benign, malignant, and borderline lesions. Serous cystadenoma is a benign lesion that requires non-surgical management if there are no symptoms. Mucinous neop...
Source: Cirugia eEspanola - December 1, 2008 Category: Surgery Authors: Jorba R, Fabregat J, Borobia FG, Busquets J, Ramos E, Torras J, Lladó L, Valls C, Serrano T, Rafecas A Tags: Cir Esp Source Type: journals

Immunohistochemical profiling of benign, low malignant potential and low grade serous epithelial ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study represents an extensive analyse of the benign and highly differentiated ovarian disease from an immunohistochemical perspective. (Source: BMC Cancer)
Source: BMC Cancer - November 26, 2008 Category: Cancer & Oncology Authors: Veronique Ouellet, Tak Hay Ling, Karine Normandin, Jason Madore, Christian Lussier, Veronique Barres, Dimcho Bachvarov, Claudine Rancourt, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson Source Type: journals

Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results support the differential expression in MMPs and TIMPs of ovarian tumors according to serous or mucinous histology. PMID: 19020757 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 23, 2008 Category: Cancer & Oncology Authors: Brun JL, Cortez A, Commo F, Uzan S, Rouzier R, Daraï E Tags: Int J Oncol Source Type: journals

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our report confirms the prognostic value of HIF-1a when restricted to poorly differentiated serous ovarian carcinoma. In addition it shows that this association is elusive, since it is not only methodology-related but it can be antibody-depended. There is adequate evidence to speculate that targeting HIF-1a could improve the long-term prognosis of these patients In order to increase the overall sensitivity of the immunoassay, maintaining acceptable levels of specificity, a panel of antibodies should be used. (Source: BMC Cancer)
Source: BMC Cancer - November 16, 2008 Category: Cancer & Oncology Authors: Alexandros Daponte, Maria Ioannou, Ilias Mylonis, George Simos, Marcos Minas, Ioannis E Messinis and George Koukoulis Source Type: journals

Serous and seromucinous infantile ovarian cystadenomas-A study of 42 cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The rarity of infantile ovarian cystadenoma (CA) accounts for the very little knowledge about their behaviour. The aim of this retrospective study is to highlight the modes of presentation and to evaluate the treatments and the recurrence risks of these benign tumours. Relation to adult epithelial ovarian tumours is discussed. The medical records and imaging studies of 42 CA in 31 children less than 16 years of age operated at our institution between 1985 and 2003 were retrospectively evaluated. Mean age of first surgery was 11 and 5 years. 7/31 (22, 6%) girls presented with a bilateral CA, four of them were synchronou...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 7, 2008 Category: OBGYN Authors: Massicot R, Rousseau V, Darwish AA, Sauvat F, Jaubert F, Nihoul-Fékété C Tags: Eur J Obstet Gynecol Reprod Biol Source Type: journals

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - November 4, 2008 Category: Pathology Authors: Sung Ho Hwang, Sang Jae Noh, Hyong Jong Kwak, Kyung Ryoul Kim, Ho Sung Park, Woo Sung Moon, Myoung Ja Chung, Keun Sang Kwon, Kwan Sik Kim, Kyu Yun Jang Source Type: journals

Estrogen and progestin regulate metastasis through the PI3K/AKT pathway in human ovarian cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We investigated nm23-H1, AKT and pAKT expression by using immunohistochemical staining in ovarian clear cell adenocarcinoma, ovarian benign, borderline and malignant serous tumors and analyzed their relationship with prognostic factors. Using ES-2 and SKOV-3 ovarian cancer cell l...
Source: International Journal of Oncology - October 26, 2008 Category: Cancer & Oncology Authors: Hua K, Feng W, Cao Q, Zhou X, Lu X, Feng Y Tags: Int J Oncol Source Type: journals

Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saita...
Source: Archives of Gynecology and Obstetrics - October 21, 2008 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

RUNX3 protein is overexpressed in human epithelial ovarian cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results suggest that RUNX3 has a role in cell proliferation and viability in ovarian cancer. PMID: 18937968 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 18, 2008 Category: Cancer & Oncology Authors: Nevadunsky NS, Barbieri JS, Kwong J, Merritt MA, Welch WR, Berkowitz RS, Mok SC Tags: Gynecol Oncol Source Type: journals

Results After Conservative Treatment of Serous Borderline Tumors of the Ovary with a Micropapillary PatternEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of SBOT-MP. Nevertheless, as 2/3 of patients had bilateral ovarian involvement at the time of initial management, the recurrence rate is high. However, making definitive conclusions about the safety of conservative surgery is limited by the small sample size. So, further studies are warranted to evaluate conservative management of advanced-stage disease. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1245/s10434-008-0159-9Authors Isabelle Laurent, Institut Gustave-Roussy Servi...
Source: Annals of Surgical Oncology - September 27, 2008 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

A Comparative Analysis of Lymphatic Vessel Density in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors) With and Without Lymph Node Involvement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 483DOI: 10.1097/PGP.0b013e3181742d7cAuthors: Fadare, Oluwole M.D.; Orejudos, Michael P. M.D.; Jain, Reena M.D.; Mariappan, M. Rajan M.D., Ph.D.; Hecht, Jonathan L. M.D., Ph.D.; Renshaw, Idris L. M.D., Ph.D.; Hileeto, Denise M.D.; Wang, Sa A. M.D.; Ghofrani, Mohiedean M.D.; Liang, Sharon X. M.D., Ph.D. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - September 20, 2008 Category: Pathology Tags: Abstract HTML PDF (295 K) Source Type: journals

Accuracy of intraoperative frozen section in the diagnosis of ovarian tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Frozen section appears to be an accurate technique for the histopathological diagnosis of ovarian tumours. Some limitations were observed among borderline and mucinous tumours. This emphasises the great value of frozen section in the diagnosis of ovarian tumours. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - August 29, 2008 Category: OBGYN Authors: Fariba YARANDI, Z. EFTEKHAR, Narges IZADI-MOOD, Hadi SHOJAEI Tags: ORIGINAL ARTICLES Source Type: journals

Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present pilot study demonstrates that the GIPC1 protein is overexpressed in ovarian and breast cancer, which may provide an important diagnostic and prognostic marker and will constitute the basis for further study of the role that this protein plays in malignant diseases. In addition, this study suggests that human monoclonal antibodies 27.F7 and 27.B1 should be further evaluated as potential diagnostic tools. (Source: BMC Cancer)
Source: BMC Cancer - August 24, 2008 Category: Cancer & Oncology Authors: Victoria Yavelsky, Sarit Rohkin, Ruthy Shaco-Levy, Alina Tzikinovsky, Tamar Amir, Hila Kohn, Berta Delgado, Alex Rabinovich, Benjamin Piura, Gerald Chan, Gavreel Kalantarov, Ilya Trakht and Leslie Lobel Source Type: journals

Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest differences in the relation of ovarian cysts and endometriosis with risk of specific subtypes of ovarian cancer as well as the possibility that ovarian surgery in women with these conditions may lower the risk of invasive disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9207-9Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristin...
Source: Cancer Causes and Control - August 15, 2008 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: journals

SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Downregulation or inactivation of p53, Rb and/or PP2A plays a role in the progression from SBOT to invasive ovarian carcinomas. PMID: 18678400 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 2, 2008 Category: Cancer & Oncology Authors: Woo MM, Salamanca CM, Symowicz J, Stack MS, Miller DM, Leung PC, Gilks CB, Auersperg N Tags: Gynecol Oncol Source Type: journals

mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age differenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to examine mtDNA sequence variants in 118 frozen tissues of three subtypes of epithelial ovarian cancer (serous, n=48 endometrioid, n=47 and mucinous, n =23) and matched paracancerous normal tissues (n= 18) in relation to racial/ethnic and age differences. Restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-based sequencing were used to evaluate two regions of mtDNA spanning 5317 to 7608 and 8282 to 10110 bp and including ND subunits 2, 3, MT-COI, II, and III, ATPase 8, a part of ATPase 6, and tRNA genes in frozen ovarian tissues obtained from the southern reg...
Source: BioMed Central - July 28, 2008 Category: Journals (General) Authors: Felix O Aikhionbare, Sharifeh Mehrabi, Winston Thompson, Xuebiao Yao, William Grizzle and Edward Partridge Source Type: journals

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was pos...
Source: Cancer Control - June 14, 2008 Category: Cancer & Oncology Authors: Olsen CM, Nagle CM, Whiteman DC, Purdie DM, Green AC, Webb PM, Tags: Int J Cancer Source Type: journals

Distribution of microsatellite instability in Danish ovarian tumor patients and the prognostic value in ovarian cancer patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we found no association to any of the clinical parameters evaluated, although a tendency of a higher frequency of MSI was observed among serous OC. PMID: 18488714 [PubMed - in process] (Source: Oncology Research)
Source: Oncology Research - May 21, 2008 Category: Cancer & Oncology Authors: Begum FD, Høgdall CK, Kjaer SK, Blaakaer J, Christensen L, Ryan A, Jacobs IJ, Høgdall EV Tags: Oncol Res Source Type: journals

Body size and risk of epithelial ovarian and related cancers: A population-based case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was pos...
Source: International Journal of Cancer - April 30, 2008 Category: Cancer & Oncology Authors: Catherine M. Olsen, Christina M. Nagle, David C. Whiteman, David M. Purdie, Adèle C. Green, Penelope M. Webb, Australian Cancer Study (Ovarian Cancer) and Australian Ovarian Cancer Study Group Source Type: journals

Laparoscopy-assisted cystectomy for large adnexal cystsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Laparoscopy-assisted surgery is feasible and safe for women with large benign adnexal cysts and result s in a short surgery time. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0651-2Authors Ahmet Göçmen, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyTuba Atak, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyMustafa Uçar, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyFatih Şanlıkal, Ümraniye Education and Res...
Source: Archives of Gynecology and Obstetrics - April 23, 2008 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Surgical treatment of a rare primary renal carcinoid tumor with liver metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Early surgical intervention, together with careful surveillance and follow-up, can achieve successful long-term outcomes in patients with this rare malignancy. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 22, 2008 Category: Cancer & Oncology Authors: Roberto Gedaly, Hoonbae Jeon, Thomas D Johnston, Patrick P McHugh, Randall G Rowland and Dinesh Ranjan Source Type: journals

Serous borderline tumor of the paratestisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pathology International, Volume 58, Issue 5, Page 311-316, May 2008. Reported herein is a case of serous borderline tumor (SBT, ovarian epithelial type tumor) of the paratestis, involving the tunica vaginalis, in a 64-year-old man. The patient complained of right hydrocele; puncture cytology of the turbid fluid pointed to ... (Source: Pathology International)
Source: Pathology International - April 21, 2008 Category: Pathology Tags: article Source Type: journals