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Discontinuation of Radiation Treatment among Medicaid-Enrolled Women with Local and Regional Stage Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: For women with nonmetastatic breast cancer, radiation therapy is recommended as a necessary component of the breast conserving surgery (BCS) treatment option. The degree to which Medicaid-enrolled women complete recommended radiation therapy protocols is not known. We evaluate radiation treatment completion rates for Medicaid enrollees aged 18[ndash]64 diagnosed with breast cancer. We determine clinical and socio-demographic factors associated with not starting treatment, and with interruptions or not completing radiation treatment. Using data from the Washington State Cancer Registry linked to Medicaid enrollmen...
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Scott D. Ramsey, Steven B. Zeliadt, Lisa C. Richardson, Lori A. Pollack, Hannah Linden, David K. Blough, Mahesh Keitheri Cheteri, Lauri Tock, Krisztina Nagy, Nancy Anderson Source Type: journals

Early Response to Neo-adjuvant Chemotherapy in Carcinoma of the Breast Predicts Both Successful Breast-Conserving Surgery and Decreased Risk of Ipsilateral Breast Tumor RecurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the early response to neo-adjuvant chemotherapy may be a useful predictor of both selection of surgical method and IBTR risk. (Source: The Breast Journal)
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Makoto Ishitobi, Yoshifumi Komoike, Kazuyoshi Motomura, Hiroki Koyama, Hideo Inaji Source Type: journals

Mastectomy not being overused for breast cancer treatment, study suggestsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With there being a concern that mastectomy is excessively used as a treatment for breast cancer, a survey of nearly 2,000 women indicates that breast-conserving surgery was attempted as the initial therapy for about 75 percent of those surveyed, according to a new study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 18, 2009 Category: Science Source Type: news

Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The marked increase in the 1990s in the use of adjuvant therapy for DCIS patients treated with BCS in the community setting only partially explains the 50% decline in risk of recurrence risk. Changes in pathology factors have likely also contributed to this decline. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 18, 2009 Category: Cancer & Oncology Authors: Laurel HabelNinah AchacosoReina HaqueLarissa NekhlyudovSuzanne FletcherStuart SchnittLaura CollinsAnn GeigerBalaram PuligandlaLuana ActonCharles Quesenberry Source Type: journals

MRI Versus Ultrasonography And Mammography For Preoperative Assessment Of Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Accurate assessment of primary tumor size is an essential part of management in breast cancer patients. Tumor size is part of the TNM system used to stage breast cancer and provide prognostic information. Adaptation of the principles of breast conservation surgery requires evaluation of tumor size to judge appropriateness and extent of surgery. Precise measurement of tumor size is also important to monitor response to neoadjuvant chemotherapy for locally advanced tumors. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Randomized Clinical Trials in Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer remains the most common cancer diagnosed in women and the second leading cause of cancer-related deaths in this group. Significant advances in the treatment of breast cancer and in the ability to screen for the disease mean that it is also one of the most curable forms of cancer. Long-term updates of the trials reviewed in the previous edition of this article have demonstrated that breast-conserving therapy remains a viable option for most patients, and that local control is related to overall survival. New chemotherapeutic options and endocrine therapies are available to select subsets of patients, and the u...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Aimee M. Crago, Michelle Azu, Shannon Tierney, Monica Morrow Source Type: journals

Science Weekly: Top 10 myths of ecological livingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Duncan Clark, Guardian environment writer and author of The Rough Guide to Green Living, tells us about his top 10 eco myths. (1:25)In the newsjam we look at Britain's renewable energy targets, a new technique to regrow breasts following mastectomy, a recent spate of cancer deaths among rescuers after 9/11, and the controversy over whether dinosaurs were warm-blooded. (13:59)Guardian religious affairs correspondent Riazat Butt speaks to delegates at a summit at Windsor Castle as religious leaders are asked to help save the planet by the UN secretary general. (25:12)We air some of your recent postings on our blog, Facebook ...
Source: Guardian Unlimited Science - November 16, 2009 Category: Science Authors: Alok Jha, Duncan Clark, Robin McKie, Andy Duckworth, Riazat Butt, David Adam, Ban Ki-moon Tags: Science Environment Climate change Copenhagen climate change conference 2009 Religion Kyoto protocol Carbon emissions Carbon offsetting Medical research breast cancer breast-conserving surgery (lumpectomy) Renewable energy Technolo Source Type: news

Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence TomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As breast cancer screening rates increase, smaller and more numerous lesions are being identified earlier, leading to more breast-conserving surgical procedures. Achieving a clean surgical margin represents a technical challenge with important clinical implications. Optical coherence tomography (OCT) is introduced as an intraoperative high-resolution imaging technique that assesses surgical breast tumor margins by providing real-time microscopic images up to 2 mm beneath the tissue surface. In a study of 37 patients split between training and study groups, OCT images covering 1 cm2 regions were acquired from surgical margi...
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Authors: Nguyen, F. T., Zysk, A. M., Chaney, E. J., Kotynek, J. G., Oliphant, U. J., Bellafiore, F. J., Rowland, K. M., Johnson, P. A., Boppart, S. A. Tags: Systems Biology and Emerging Technologies Source Type: journals

Increased Cancer Recurrence Linked to High Breast DensityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with invasive breast cancer and high-density breast tissue who undergo breast-conserving surgery without radiotherapy are likely at an increased risk of recurrence, according to a study published online Nov. 9 in Cancer. (Source: Modern Medicine)
Source: Modern Medicine - November 11, 2009 Category: Journals (General) Source Type: info

Intramammarian flap reconstruction (IFR) technique in breast conserving surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19913416 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - November 11, 2009 Category: Cancer & Oncology Authors: Rageth CJ, Tausch C Tags: breast Source Type: journals

[Radiofrequency ablation of breast carcinomas: preliminary results of a clinical trial.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Radiofrequency ablation of breast carcinomas is feasible, well tolerated, safe, and efficacious in nearly 90% of invasive tumors. The efficacy of the technique should be confirmed through extended follow-up of patients without subsequent surgical intervention in carefully designed and monitored phase III trials. PMID: 19913265 [PubMed - as supplied by publisher] (Source: Radiologia)
Source: Radiologia - November 11, 2009 Category: Radiology Authors: Apesteguía L, Ovelar A, Domínguez-Cunchillos F, Alfaro C, Trujillo R, Sanz MA, de Miguel C, Reparaz B, Ruiz de Azúa Y Tags: Radiologia Source Type: journals

Second CT simulation advised for whole-breast radiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women receiving whole-breast radiation therapy after breast-conserving surgery (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 10, 2009 Category: Radiology Source Type: info

SAVI Brachytherapy For Breast Cancer Marks Three-Year Anniversary Of First Treatment-Shorter, Easier Radiation Treatment Available To More WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This month marks three years since physicians began offering SAVI(TM) radiation treatment as part of breast conservation therapy for early- stage breast cancer -- a major milestone in breast brachytherapy. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 10, 2009 Category: Cancer & Oncology Source Type: news

Denser breasts linked to increased risk for cancer recurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mammographic breast density significantly affects the risk for the development of local disease recurrence after breast-conserving surgery, Canadian researchers report. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - November 10, 2009 Category: Cancer & Oncology Source Type: news

Chronic Pain Can Be a Problem Years After Breast SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite breast-conserving surgery and other advances, post-breast surgery pain and sensory disturbances remained problems for many women in a Danish survey reported in the Nov. 11 issue of the Journal of the American Medical Association. (Source: Modern Medicine)
Source: Modern Medicine - November 10, 2009 Category: Journals (General) Source Type: info

Denser breasts linked to increased risk for cancer recurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mammographic breast density significantly affects the risk for the development of local disease recurrence after breast-conserving surgery, Canadian researchers report. (Source: MedWire News - Breast Cancer)
Source: MedWire News - Breast Cancer - November 10, 2009 Category: Cancer & Oncology Source Type: news

Conservative surgery with and without radiotherapy in elderly patients with early-stage breast cancer: A prospective randomised multicentre trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast conserving therapy (BCT) including postoperative irradiation of the remaining breast tissue is generally accepted as the best treatment for the majority of patients with early-stage breast cancer. The question is whether there is a necessity for irradiating all patients. Between 2001 and 2005, 749 women aged 55-75 years with infiltrating breast carcinoma were randomly assigned to breast conservative surgery, with or without radiotherapy (RT), to evaluate the incidence of in-breast recurrence (IBR). After 5 years of median follow-up, the cumulative incidence of IBR was 2.5% in the surgery-only arm and 0.7% in the...
Source: Breast - November 10, 2009 Category: Cancer & Oncology Authors: Tinterri C, Gatzemeier W, Zanini V, Regolo L, Pedrazzoli C, Rondini E, Amanti C, Gentile G, Taffurelli M, Fenaroli P, Tondini C, Sacchetto G, Sismondi P, Murgo R, Orlandi M, Cianchetti E, Andreoli C Tags: breast Source Type: journals

Increased breast density predicted local disease recurrence after breast-conserving surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HemOncToday.com)
Source: HemOncToday.com - November 9, 2009 Category: Cancer & Oncology Source Type: info

Changes in and predictors of length of stay in hospital after surgery for breast cancer between 1997/98 and 2004/05 in two regions of England: a population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The number of days spent in hospital after breast cancer surgery has continued to decline for several decades. The change from mastectomy to BCS accounts for only 9% of the overall decrease in LOS. Other explanations include the adoption of new techniques and practices, such as sentinel lymph node biopsy and early discharge. This study has identified wide variation in practice with substantial cost implications for the NHS. Further work is required to explain this variation. (Source: BMC Health Services Research)
Source: BMC Health Services Research - November 9, 2009 Category: Journals (General) Authors: Amy DowningMark LansdownRobert WestJames ThomasGill LawrenceDavid Forman Source Type: journals

Mammographic density and the risk of breast cancer recurrence after breast-conserving surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with invasive breast cancer who are treated with breast-conserving surgery and radiotherapy face a cumulative risk of local disease recurrence of approximately 10% at 10 years. To the authors' knowledge, the role of mammographic density as a risk factor for the development of local recurrence has not been thoroughly evaluated to date.Medical records were reviewed for 335 patients who underwent breast-conserving surgery for invasive breast cancer and for whom a pretreatment mammogram was available. Information was recorded concerning mammographic density as well as tumor features, patient characteristics, and adjuvant...
Source: Cancer - November 9, 2009 Category: Cancer & Oncology Authors: Tulin Cil, Eve Fishell, Wedad Hanna, Ping Sun, Ellen Rawlinson, Steven A. Narod, David R. McCready Source Type: journals

["Scarless" surgery in the treatment of breast cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes four approach routes for scarless surgery (periareolar, axillary, submammary, lateral chest) in different contexts of the oncological breast disease. The application of these incisions in the conservative treatment of breast cancer requires making a wide subcutaneous dissection over the tumour location, and a local reconstruction with adjacent breast tissue, so as not to deform the breast contour, as well as moving the nipple with its areola, thus avoiding the surgical modification of the other breast to maintain symmetry between both. We describe the use of hidden incisions to perform mastectomies t...
Source: Cirugia eEspanola - November 5, 2009 Category: Surgery Authors: Acea Nebril B Tags: Cir Esp Source Type: journals

Pregnancy after breast cancer: The importance of active counselling and planning.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Pregnancy after breast cancer does not confer a poor prognosis. A higher rate of pregnancy than expected was found after treatment, possibly due to newer treatments including fertility preservation and also possibly due to the active counselling programme in this unit. Patients should have active counselling about fertility when planning treatment and fertility conservation can then be incorporated into a treatment plan. PMID: 19892553 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - November 4, 2009 Category: Cancer & Oncology Authors: Rippy EE, Karat IF, Kissin MW Tags: breast Source Type: journals

Ampk-Independent Down-Regulation Of Cflip And Sensitization To Trail-Induced Apoptosis By Ampk Activators.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a TNF superfamily member that is being considered as a new strategy in anticancer therapy because of its ability to induce apoptosis, alone or in combination with other stimuli, in many cancer cells. AMP-activated protein kinase (AMPK) is an evolutionarily conserved key regulator of cellular energy homeostasis that protects the cell from energy depletion and stress by activating several biochemical pathways that lead to the conservation, as well as generation, of ATP. Here we report that a number of AMPK activators, including the small molecule acti...
Source: Biochemical Pharmacology - November 4, 2009 Category: Drugs & Pharmacology Authors: García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A Tags: Biochem Pharmacol Source Type: journals

The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, preoperative MRI in patients with ILC can reduce re-excision rates without increasing the rate of mastectomies. Content Type Journal ArticleCategory Clinical trialDOI 10.1007/s10549-009-0616-6Authors R. M. Mann, Radboud University Nijmegen Medical Centre Department of Radiology huispost 667, Geert Grooteplein 10 P.O. Box 9101 6500 HB Nijmegen The NetherlandsC. E. Loo, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital Department of Radiology Amsterdam The NetherlandsT. Wobbes, Radboud University Nijmegen Medical Centre Department of Surgery Nijmegen The NetherlandsP. Bult, Radboud Univers...
Source: Breast Cancer Research and Treatment - November 3, 2009 Category: Cancer & Oncology Tags: breast Cancer Research and Treatment Source Type: journals

The Portuguese version of the Body Image Scale (BIS) - psychometric properties in a sample of breast cancer patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The Portuguese BIS proved to be a reliable and valid measure of body image concerns in a sample of breast cancer patients, allowing a brief and comprehensive assessment, both on clinical and research settings. PMID: 19892597 [PubMed - as supplied by publisher] (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - November 3, 2009 Category: Nursing Authors: Moreira H, Silva S, Marques A, Canavarro MC Tags: Eur J Oncol Nurs Source Type: journals

Obesity is a Risk Factor for Developing Postoperative Lymphedema in Breast Cancer PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Lymphedema (LE) is a well-known postoperative complication after axillary node dissection (ALND). Although, sentinel lymph node dissection (SLND) involves more focused surgery and less disruption of the axilla, early reports show up to 13% of patients experience some symptoms of LE. The purpose of this study was to determine predictors of arm LE in our patients under going SLND with or without an ALND. One hundred and thirty-seven breast cancer patients were treated at a comprehensive cancer center. Prospective measurement of arm volume was carried every 6 months from date of diagnosis. This data base was retrosp...
Source: The Breast Journal - November 2, 2009 Category: Cancer & Oncology Authors: Lucy K. Helyer, Marie Varnic, Lisa W. Le, Wey Leong, David McCready Source Type: journals

Patterns of Surgical Treatment for Women with Breast Cancer in Relation to AgeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although treatment recommendations have been advocated for all women with early breast cancer regardless of age, it is generally accepted that different treatments are preferred based on the age of the patient. The aim of this study was to assess the pattern of breast cancer surgery after adjusting for other major prognostic factors in relation to patient age. Data on cancer characteristics and surgical procedures in 31,298 patients with early breast cancer reported to the National Breast Cancer Audit between 1999 and 2006 were used for the study. There was a close association between age and surgical treatment p...
Source: The Breast Journal - November 2, 2009 Category: Cancer & Oncology Authors: Jim Wang, James Kollias, Margaret Boult, Wendy Babidge, Helen N. Zorbas, David Roder, Guy Maddern Source Type: journals

Effective breast reconstruction in female veteransEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Breast reconstruction can be effectively delivered within the Veterans Affairs system. It is essential that sufficient Veterans Affairs resources be deployed to address the increasing reconstructive needs of female veterans. (Source: American Journal of Surgery)
Source: American Journal of Surgery - November 1, 2009 Category: Surgery Authors: Mimi Leong, Chuma J. Chike-Obi, C. Bob Basu, Edward I. Lee, Daniel Albo, David T. Netscher Tags: The Association of VA Surgeons Source Type: journals

Delayed radiotherapy for breast cancer patients in integrated delivery systems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Timely RT should be facilitated through physician and patient education, navigation, and notification programs to improve quality of care. Queues for RT appointments should be evaluated on an ongoing basis to ensure adequate access. Future research should examine modifiable barriers to RT timeliness and whether delays impact long-term outcomes. PMID: 19895182 [PubMed - in process] (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - November 1, 2009 Category: Health Management Authors: Gold HT, Thwin SS, Buist DS, Field TS, Wei F, Yood MU, Lash TL, Quinn VP, Geiger AM, Silliman RA Tags: Am J Manag Care Source Type: journals

No Evidence of Mastectomy Overuse Found in Large SurveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
More than three-quarters of women newly diagnosed with intraductal or stage I or II breast cancer elected breast-conserving surgery as their initial surgical therapy, according to a survey of nearly 2,000 women. (Source: Ob.Gyn. News)
Source: Ob.Gyn. News - November 1, 2009 Category: OBGYN Authors: ROBERT FINN Tags: Gynecology Source Type: journals

Disparities in medical care among commercially insured patients with newly diagnosed breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
African-American women have increased breast cancer mortality compared with white women. Diagnostic and treatment gaps may contribute to this disparity.In this retrospective, longitudinal cohort study, Southern US health plan claims data and linked medical charts were used to identify racial disparities in the diagnoses, treatment, and mortality of commercially insured women with newly diagnosed breast cancer. White women (n = 476) and African-American women (n = 99) with newly diagnosed breast cancer were identified by breast cancer claims codes (International Classification of Diseases, Ninth Revision, Clinical Modificat...
Source: Cancer - October 28, 2009 Category: Cancer & Oncology Authors: Louise J. Short, Maxine D. Fisher, Peter M. Wahl, Monique B. Kelly, Grant D. Lawless, Sandra White, Nancy A. Rodriguez, Vincent J. Willey, Otis W. Brawley Source Type: journals

Study Suggests Mastectomy Not Being Overused For Breast Cancer TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With there being a concern that mastectomy is excessively used as a treatment for breast cancer, a survey of nearly 2,000 women indicates that breast-conserving surgery was attempted as the initial therapy for about 75 percent of those surveyed, according to a study in the October 14 issue of JAMA, a theme issue on surgical care. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - October 24, 2009 Category: Cancer & Oncology Source Type: news

Although More Older Women Receive Breast-Conserving Therapy, Gaps In Treatment ExistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to a new study published in the October issue of the Journal of the American College of Surgeons, although breast-conserving surgery (BCS), commonly known as lumpectomy, is increasingly being used to treat older women with nonmetastatic invasive breast cancer, there are still significant socioeconomic and geographic disparities in the use of this type of therapy. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - October 24, 2009 Category: Cancer & Oncology Source Type: news

What is an Adequate Margin for Breast-Conserving Surgery? Surgeon Attitudes and CorrelatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Wide variation in BCS margin definition exists. Variation is similar for invasive cancer and DCIS with RT, with more specialized surgeons choosing smaller margins. In DCIS without RT, more specialized surgeons favored larger margins. A standardized margin definition may significantly affect re-excision rates. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0765-1Authors Michelle Azu, Memorial Sloan-Kettering Cancer Center Breast Service, Department of Surgery New York USAPaul Abrahamse, University of Michigan Department of Internal Medicine Ann Arbor MI USASteven...
Source: Annals of Surgical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Histological grading of invasive breast carcinoma – a simplification of existing methods in a large conservation series with long-term follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Existing grading methodology is fully applicable in the narrower context of a conservation series but can be simplified. Subdivision of EE grade 2 into a true intermediate prognosis group and a second group with a worse prognosis also adds benefit. (Source: Histopathology)
Source: Histopathology - October 21, 2009 Category: Pathology Authors: Jeremy St J Thomas, Gillian R Kerr, Wilma J L Jack, Fiona Campbell, Laura McKay, Hans-Christian Pedersen, Ian H Kunkler, David A Cameron, Udi Chetty, John M S Bartlett Source Type: journals

Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: A systematic review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19853317 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 21, 2009 Category: Radiology Authors: Nairz O, Sedlmayer F Tags: Radiother Oncol Source Type: journals

Breast cancer: Role of neoadjuvant therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Breast cancer is now considered to be a systemic disease from the outset, with no correlation seen between the intensity of local treatment and survival or recurrence. Adjuvant therapy has clearly demonstrated a reduction in local and distant relapse; neoadjuvant therapy is similarly being assessed. It aims to treat occult metastases and decrease tumour bulk. Its use has demonstrated down-staging of the tumour with increased rates of breast-conserving surgery. Though neoadjuvant therapy seems to be associated with an increase in loco-regional recurrence compared to adjuvant therapy, no overall difference in survi...
Source: International Journal of Surgery - October 19, 2009 Category: Surgery Authors: Muhammad Ishtiaq Ahmed, T.W.J. Lennard Tags: Reviews Source Type: journals

LumpectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
— Overview covers definition, preparation, risks, results of this breast-conserving surgical procedure. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - October 17, 2009 Category: Consumer Health News Source Type: news

Impact of Pathological Characteristics on Local Relapse After Breast-Conserving Therapy: A Subgroup Analysis of the EORTC Boost Versus No Boost Trial [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Young age and high-grade invasive ductal cancer were the most important risk factors for local relapse, while margin status had no significant influence. A boost dose of 16 Gy significantly reduced the negative effects of both young age and high-grade invasive cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Jones, Antonini, Hart, Peterse, Horiot, Collin, Poortmans, Oei, Collette, Struikmans, Van den Bogaert, Fourquet, Jager, Schinagl, Warlam-Rodenhuis, Bartelink Tags: Surgery, Radiation, Prognostic Studies, Radiation Oncology, Surgical Oncology breast Cancer Source Type: journals

Occult Nipple Involvement in Breast Cancer: Clinicopathologic Findings in 316 Consecutive Mastectomy Specimens [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Nipple-sparing mastectomy may be suitable for selected cases of breast carcinoma with low probability of nipple involvement by carcinoma and prophylactic procedures. A retroareolar en-face margin may be used to test for occult involvement in patients undergoing nipple-sparing mastectomy. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Brachtel, Rusby, Michaelson, Chen, Muzikansky, Smith, Koerner Tags: Diagnosis & Staging breast Cancer Source Type: journals

Prognostic Factors for Local Control After Breast Conservation: Does Margin Status Still Matter? [EDITORIALS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: MacDonald, Taghian Tags: EDITORIALS Source Type: journals

Validation of Van Nuys classification in 183 patients with screen detected DCIS, a retrospective analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: The Van Nuys Prognostic Index (VNPI) is a numerical index designed to guide treatment following Breast Conserving Surgery for DCIS. It combines size, margin and grade and separates patients into low risk group suitable for treatment with excision only, moderate risk group suitable for excision with radiotherapy and high-risk group where mastectomy is recommended. The authors tested the validity of VNPI and the proposed benefit of adjuvant radiotherapy. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Lona Jalini, G. Mazdai, I. Mokadem, H. Lucraft, D. Hemming, D. Browell Tags: Abstracts Source Type: journals

Ipsilateral breast tumour recurrence - is mastectomy the only option?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Patients who develop ipsilateral breast tumour recurrence (IBTR) after breast conserving surgery have traditionally been offered salvage mastectomy. In Guildford breast conserving surgery is offered as an option for these patients if feasible. There is little evidence in the literature on the outcome of these patients. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Tracey Irvine, H. Lane, M. Kissin Tags: Abstracts Source Type: journals

Oncoplastic breast surgery for cancer: the first 20 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: For large tumours and those in less favourable locations, standard breast conserving therapy (BCT) is being replaced by more imaginative oncoplastic breast surgery (OBS) techniques that draw on plastic surgery principles to both anticipate and avoid poor aesthetic outcomes and further reduce the rate of mastectomy. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: M.G. Berry, A. Fitoussi, F. Fama, B. Couturaud, R. Salmon Tags: Abstracts Source Type: journals

Does ‘intra-operative assessment’ of sentinel lymph node biopsy increase patient's anxiety?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Intra-operative assessment (IOA) of sentinel lymph node biopsy (SLNB) with touch imprint cytology (TIC) is a recognized technique to stage the axilla. Axillary clearance is performed during the primary procedure (breast conservation surgery/mastectomy) if IOA is positive. This means that there is some uncertainty pre-operatively in the patient's mind regarding the extent of surgery that will be undertaken. The aim of this study was to see if IOA lead to increase in patient's anxiety about the operation. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Tapan Sircar, A. Eyers, D. Flavin, S. Harries, D. Clarke, L. Jones Tags: Abstracts Source Type: journals

Loco-regional and systemic recurrence rates following breast conserving surgery for breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to examine recurrence rates in breast cancer patients who underwent breast conserving surgery, to identify factors associated with recurrence and to compare locoregional recurrence rates to national guidelines issued by the Association of Breast Surgery at BASO, 2005. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Elaine Burns, C. Abson, V. Masum, I. Ahmed Tags: Abstracts Source Type: journals

What are the predictive factors of positive resection margin in infiltrating lobular carcinoma treated by breast conserving surgery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aims: To determine whether infiltrating lobular carcinoma (ILC) is associated with high positive margin rates for single stage lumpectomy procedures. To define clinical or histological characteristics that might influence the positive margin rate,thereby affecting treatment decisions. To identify factors predictive of margin involvement and the need for re-operation. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Eisa Nael, P. Pemberton, M. Hwang, S. Rahmani, V. Raghavan Tags: Abstracts Source Type: journals

Ex vivo terahertz pulsed imaging to differentiate malignant from normal breast tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: About 60-70% of patients with early breast cancer undergo breast-conserving surgery. Of these, approximately 25-30% are found to have close or involved margins at final histology and require further surgery to ensure clear margins. Current methods of intra-operative margin assessment are unreliable. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Uttam Soni, M. Kontos, P. Ashworth, A. Olorunsola, S. Pinder, A. Purushotham Tags: Abstracts Source Type: journals

Choosing mastectomy to avoid adjuvant radiotherapy. Is this accurate from previous practice or misguided patient perception?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Breast cancer surgery continues to evolve, aiming to conserve breast tissue and minimise axillary dissection. There is a general impression however that mastectomy avoids the need for subsequent radiotherapy particularly in elderly patients. Adjuvant radiotherapy following mastectomy (ARFM) may still be required for close resection margins or nodal disease. We reviewed ARFM for patients in our symptomatic breast unit. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Sunil Amonkar, P. Sinha, A. Anand, S. Lari, P. Truran, J. Hardman, R. Brookstein Tags: Abstracts Source Type: journals

Can clinical and radiological features predict the need for Sentinel Lymph Node Biopsy in patients with a pre-operative diagnosis of Ductal Carcinoma in Situ, who are eligible for breast conservation surgery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The role for Sentinel Lymph Node Biopsy (SLNB) in patients eligible for breast conservation surgery (BCS) remains controversial. 10-30% of patients with pre-operative diagnosis of DCIS will have an invasive component subsequently detected in the resected specimen. These patients will require a second operation for axillary staging. We sought to identify the characteristics of patients with a pre-operative diagnosis of DCIS eligible for BCS who are most likely to harbour an invasive component, with the aim of identifying those who might benefit from SLNB. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Samantha Williams, M. Nixon, R. Sutton Tags: Abstracts Source Type: journals