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Screening for colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A record from the CRD Health Techology Assessment Database. Published in July 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Colon and rectum)
Source: Gastroenterology and Liver Diseases Specialist Library - Colon and rectum - November 20, 2009 Category: Gastroenterology Source Type: organizations

Synta Presents Preclinical Data On Next Generation Hsp90 Inhibitor, STA-9090Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Synta Pharmaceuticals Corp, a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced that preclinical data presented at the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics shows that STA-9090, a novel, synthetic inhibitor of heat shock protein 90 (Hsp90), demonstrated strong activity in multiple tumor models. (Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - November 20, 2009 Category: Cancer & Oncology Source Type: news

Definitive molecular cytogenetic characterization of 15 colorectal cancer cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In defining the genetic profiles in cancer, cytogenetically aberrant cell lines derived from primary tumors are important tools for the study of carcinogenesis. Here, we present the results of a comprehensive investigation of 15 established colorectal cancer cell lines using spectral karyotyping (SKY), fluorescence in situ hybridization, and comparative genomic hybridization (CGH). Detailed karyotypic analysis by SKY on five of the lines (P53HCT116, T84, NCI-H508, NCI-H716, and SK-CO-1) is described here for the first time. The five lines with karyotypes in the diploid range and that are characterized by defects in DNA mis...
Source: Genes, Chromosomes and Cancer - November 20, 2009 Category: Cancer & Oncology Authors: Turid Knutsen, Hesed M. Padilla-Nash, Danny Wangsa, Linda Barenboim-Stapleton, Jordi Camps, Nicole McNeil, Michael J. Difilippantonio, Thomas Ried Source Type: journals

Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: LGRs accounted for 25% of germline MMR mutations identified in 28 Slovakian HNPCC families. A high frequency of LGRs among the MSH2 mutations provides a rationale for a MLPA screening of the Slovakian HNPCC families prior scanning by DNA sequencing. LOH at part of the informative loci confined to the MLH1 or MSH2 gene (heterozygous LGR region, SNP, or microsatellite) is a novel finding and can be regarded as a partial LOH. The conversion begins within the gene, and the details of conversion tracts are discussed for each case. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Katarina ZavodnaTomas KrivulcikMaria Gerykova BujalkovaTomas SlamkaDavid MartinickyDenisa IlencikovaZdena Bartosova Source Type: journals

Adequacy of Lymph Node Dissection Should be Taken into Consideration While Determining the Prognostic Significance of the Lymph Node Ratio: In Regard to Kim et al. (Int J Radiat Oncol Biol Phys 2009;74:796–802)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest the article by Kim et al. , which examined the value of the lymph node ratio (LNR) as a prognostic factor in patients with Stage III rectal cancer treated with total mesorectal excision followed by chemoradiotherapy. In agreement with this article, there are several others reporting the importance of LNR as a prognostic factor in colorectal cancer . However, we do have some concerns about the generalization of the conclusion of the Kim et al. study to all Stage III rectal cancer patients. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Faysal Dane, Mehmet Akif Öztürk, Serdar Turhal Tags: Letters to the Editor Source Type: journals

Obesity and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precu...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Mini-Review Source Type: journals

Avoiding midazolam overdose: summary of a safety report from the National Patient Safety AgencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 19, 2009 Category: Journals (General) Authors: Lamont, T., Matthew, L., Cousins, D., Green, J. Tags: Endoscopy, Patients, colon cancer, Child and adolescent psychiatry (paedatrics), Child health, Hospice, Child and adolescent psychiatry, Adult intensive care, Dentistry and oral medicine, Gastrointestinal surgery, General surgery, Poisoning, Medical error Source Type: journals

The Comparison of Clinical Effect of Rh-endostar on Retreated Non-Small Cell Lung Cancer and Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The clinical efficacy of rh-endostatin on retreated colorectal cancer was better than on retreated non-small cell lung cancer, which suggested that it was necessary to perform more clinical observations on the digestive tumors. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Unexplained Liver Hemorrhage After Metastasis Radiofrequency AblationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered that liver metastases meant a very poor prognosis, today, due to improved systemic therapy, many patients will be candidates for local hepatic treatments such as surgery or less aggressive radiofrequency ablation. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 19, 2009 Category: Gastroenterology Tags: colorectal cancer Source Type: news

Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals

Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glutathione S-transferase P1 (GSTP1) participates in detoxification of potentially genotoxic compounds that may alter the efficacy and toxicity of platinum-based chemotherapy. We analyzed the influence of I105V polymorphism of GSTP1 on clinico-pathological features and outcomes in 166 Chinese patients with metastatic colorectal carcinoma who had been treated with first-line FOLFOX-4. Combined analysis of GSTP1 I105V, ERCC1-118, and XPD-751 polymorphisms was also conducted. The results showed that, in comparison with Caucasian populations, a remarkably lower prevalence of Val105 allele variants was noted (24.7%). Patients w...
Source: Cancer Science - November 19, 2009 Category: Cancer & Oncology Authors: Yen-Chung Chen, Cheng-Hwai Tzeng, Po-Min Chen, Jen-Kou Lin, Tzu-Chen Lin, Wei-Shone Chen, Jeng-Kae Jiang, Huann-Sheng Wang, Wei-Shu Wang Source Type: journals

A blood-based biomarker panel for stratifying current risk for colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Colorectal cancer (CRC) is often curable and preventable using current screening modalities. Unfortunately, screening compliance remains low, partly due to patient dissatisfaction with faecal/endoscopic testing. Recent guidelines advise CRC screening should begin with risk stratification. A blood-based test providing clinically actionable CRC risk information would likely improve screening compliance and enhance clinical decision making. We analyzed 196 gene expression profiles to select candidate CRC biomarkers. qRT-PCR was performed on 642 samples to develop a 7-gene biomarker panel using 112 CRC/120 controls (training s...
Source: International Journal of Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Kenneth Wayne Marshall, Steve Mohr, Faysal El Khettabi, Nadejda Nossova, Samuel Chao, Weisheng Bao, Jun Ma, Xiao-Jun Li, Choong-Chin Liew Source Type: journals

Cetuximab-induced cutaneous toxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The most frequent cutaneous side effect reported in this series was acneiform eruption. The authors observed that all women with acneiform rash had only limited facial involvement, whereas all but one man experienced more widespread lesions of the face, the back and the chest. We found no association between the extent and severity of cutaneous eruptions (grade 1 vs. grade 2) and patients' response to therapy. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - November 19, 2009 Category: Dermatology Authors: H Tomková, M Kohoutek, M Zábojníková, M Pospí[scaron]ková, L Ostřížková, M Gharibyar Source Type: journals

Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: S. gallolyticus most likely plays an essential role in the oncogenic progression of normal colorectal mucosa to adenoma and to CRC. This promoting/propagating role of S. gallolyticus might take place by utilizing certain inflammatory, anti-apoptotic, and angiogenic factors of transformation including NF-kappaB and IL-8. (Source: BMC Cancer)
Source: BMC Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Ahmed AbdulamirRand HafidhLayla MahdiTarik AljebooriFatimah Abu bakar Source Type: journals

Estrogen Deprivation Therapy and Colon Cancer Risk in Breast Cancer PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Breast Journal)
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: David O. Malaka, Olufunmilayo I. Olopade Source Type: journals

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that chemo- and immuno-resistance to anthracyclines are associated in colon cancer cells and rely on a common mechanism, that is the inability of doxorubicin to induce iNOS. Therefore NO donors might represent a promising strategy to restore both chemosensitivity and immunosensitivity to doxorubicin in resistant cells. (Source: Molecular Cancer)
Source: Molecular Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Sara De BooJoanna KopeckaDavide BrusaElena GazzanoLina MateraDario GhigoAmalia BosiaChiara Riganti Source Type: journals

Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial [Gastrointestinal Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results do not support the routine clinical use of the evaluated polymorphisms, including UGT1A1*28. Further investigation of XRCC1, ERCC2, and GSTP1 as potential predictors of irinotecan toxicity is warranted. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Braun, Richman, Thompson, Daly, Meade, Adlard, Allan, Parmar, Quirke, Seymour Tags: Clinical Trials, Chemotherapy, Translational Oncology, Gastrointestinal, cancer Biomarkers Gastrointestinal cancer Source Type: journals

The anticancer effects of sodium selenite and selenomethionine on human colorectal carcinoma cell lines in nude mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The studies were carried out on nude mice bearing human colorectal carcinoma SW480 cell line xenografts to evaluate the chemotherapeutic potential of selenium containing compounds such as sodium selenite (SSe) and selenomethionine (SeMet). Three doses of anticancer drugs were used, including 0.1 mg/kg/day SSe (LSSe), 2 mg/kg/day SSe (HSSe), and 2 mg/kg/day SeMet. We explored the anticancer effect of SSe and SeMet administered by IP injection for 21 days. We observed the pathologic changes and the cell apoptosis in tumor tissue by HE staining and TUNNEL assay after HSSe and SeMet treatment. GSH level and antioxidant enz...
Source: Oncology Research - November 18, 2009 Category: Cancer & Oncology Authors: Yang Y, Huang F, Ren Y, Xing L, Wu Y, Li Z, Pan H, Xu C Tags: Oncol Res Source Type: journals

Poniard drug OK in mid-stage cancer studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poniard Pharmaceuticals Inc., which stumbled with its cancer drug picoplatin in a Phase III trial, hit the main goal of a mid-stage metastatic colorectal cancer study using the chemotherapy agent, the company said Wednesday. (PARD) (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - November 18, 2009 Category: American Health Source Type: journals

Poniard drug OK in mid-stage cancer studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poniard Pharmaceuticals Inc., which stumbled with its cancer drug picoplatin in a Phase III trial, hit the main goal of a mid-stage metastatic colorectal cancer study using the chemotherapy agent, the company said Wednesday. (PARD) (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 18, 2009 Category: Biotechnology Source Type: journals

Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Colonic cell proliferation was promoted via the JNK pathway in the presence of a HFD but not in the presence of a ND. This novel mechanism may explain the involvement of the JNK pathway in the effect of dietary fat intake on colon carcinogenesis. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Endo, H, Hosono, K, Fujisawa, T, Takahashi, H, Sugiyama, M, Yoneda, K, Nozaki, Y, Fujita, K, Yoneda, M, Inamori, M, Wada, K, Nakagama, H, Nakajima, A Tags: colon cancer colorectal cancer Source Type: journals

International trials: Panitumumab delays disease progression in colon cancer metsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BERLIN—A pair of colon cancer trials using panitumumab (Vectibix) not only proved the efficacy of the drug in patients with nonmutated KRAS but also highlighted the importance of ascertaining KRAS status. Trial 181 evaluated panitumumab in combination with FOLFIRI as a second-line treatment for metastatic colorectal cancer, while trial 203 paired the anti-EGFR agent with FOLFOX4 as first-line treatment. (Source: Cancer Network)
Source: Cancer Network - November 18, 2009 Category: Cancer & Oncology Source Type: info

Ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 18, 2009 Category: Journals (General) Authors: Hamilton, W., Menon, U. Tags: Neurogastroenterology, Clinical trials (epidemiology), Epidemiologic studies, Stomach and duodenum, General practice / family medicine, Pain (neurology), Menopause (including HRT), colon cancer, Gynecological cancer, Screening (oncology), Radiology, Disab Source Type: journals

Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) developed as a selective inhibitor of cyclooxygenase-2 (COX-2). Despite the associated cardiovascular toxicity risk, celecoxib has been found to be effective in reducing cancer risk in animal and human studies. In the present study the antiproliferative activity of novel nitro-oxy-methyl substituted analogues of celecoxib (NO-cel), potentially less cardiotoxic, has been investigated in vitro on human colon cancer cells and compared with action of the parent drug. Moreover, experiments were performed in order to evaluate whether COX-2 pharmacological inhibition...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Bozzo F, Bassignana A, Lazzarato L, Boschi D, Gasco A, Bocca C, Miglietta A Tags: Chem Biol Interact Source Type: journals

Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the roles of p53 and gamma-H2AX following oxaliplatin treatment, as they are important effector proteins for apoptosis and DSB repair, respectively. Both phosphorylated-p53 (Ser-15) and gamma-H2AX were up-regulated and accumulated in the nuclei of p53-wild type human colorectal cancer HCT116 cells after exposure to oxaliplatin. Concomitantly, oxaliplatin-induced G2/M arrest was associated with a reduction in both cyclin B1 expression and phosphorylated-CDC2 (Thr-161). Release of G2/M arrest by caffeine was accompanied by a decrease in the levels of p53/p21; however, gamma-H2AX levels were unc...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Chiu SJ, Lee YJ, Hsu TS, Chen WS Tags: Chem Biol Interact Source Type: journals

Poniard Pharmaceuticals Announces Updated Positive Clinical Data From Phase 2 Trial Of Picoplatin In Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poniard Pharmaceuticals, Inc. (Nasdaq: PARD) announced updated clinical data from its randomized, controlled Phase 2 trial of picoplatin in patients with metastatic colorectal cancer (CRC). (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 18, 2009 Category: Cardiology Tags: colorectal cancer Source Type: news

Poniard Pharmaceuticals Announces Updated Positive Clinical Data From Phase 2 Trial Of Picoplatin In Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poniard Pharmaceuticals, Inc. (Nasdaq: PARD) announced updated clinical data from its randomized, controlled Phase 2 trial of picoplatin in patients with metastatic colorectal cancer (CRC). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: colorectal cancer Source Type: news

Colorectal Cancer Screening in Elderly African-American PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s10620-009-1037-4Authors Shashideep Singhal, Chicago Medical School at Rosalind Franklin University Gastroenterology, Department of Internal Medicine North Chicago IL USASiddharth Mathur, The Brooklyn Hospital Center Gastroenterology Brooklyn NY USAKris Anand, Chicago Medical School at Rosalind Franklin University Gastroenterology North Chicago IL USA Journal Digestive Diseases and SciencesOnline ISSN 1573-2568Print ISSN 0163-2116 (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - November 18, 2009 Category: Gastroenterology Tags: Digestive Diseases and Sciences Source Type: journals

The anti-angiogenic isoforms of VEGF in health and disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anti-angiogenic VEGF (vascular endothelial growth factor) isoforms, generated from differential splicing of exon 8, are widely expressed in normal human tissues but down-regulated in cancers and other pathologies associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys-Drash syndrome and pre-eclampsia). Administration of recombinant VEGF(165)b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma and metastatic melanoma. Splicing factors and their regulatory molecules alter splice site selection, such that...
Source: Biochemical Society Transactions - November 18, 2009 Category: Biochemistry Authors: Qiu Y, Hoareau-Aveilla C, Oltean S, Harper SJ, Bates DO Tags: Biochem Soc Trans Source Type: journals

Clinical relevance associated to the analysis of circulating tumour cells in patients with solid tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The distant growth of tumour cells escaping from primary tumours, a process termed metastasis, represents the leading cause of death among patients affected by malignant neoplasias from breast and colon. During the metastasis process, cancer cells liberated from primary tumour tissue, also termed circulating tumour cells (CTCs), travel through the circulatory and/or lymphatic systems to reach distant organs. The early detection and the genotypic and phenotypic characterisation of such CTCs could represent a powerful diagnostic tool of the disease, and could also be considered an important predictive...
Source: Clinical and Translational Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Multimodal preoperative evaluation system in surgical decision making for rectal cancer: a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion MPE is an effective strategy in preoperative staging and more accurate than other available strategies in surgical decision making for rectal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0839-3Authors Xiaodong Wang, Sichuan University Anal-Colorectal Surgery, West China Hospital 37, Guo Xue Xiang Chengdu China 610041Donghao Lv, Sichuan University West China School of Medicine Chengdu ChinaHuan Song, Sichuan University West China School of Medicine Chengdu ChinaLei Deng, Sichuan University West China School of Medicine Chengdu ChinaQiang Gao, Sichuan Uni...
Source: International Journal of Colorectal Disease - November 18, 2009 Category: Gastroenterology Tags: International Journal of colorectal Disease Source Type: journals

Expression of HMG1 and metastasis of colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00384-009-0844-6Authors Viroj Wiwanitkit, Wiwanitkit House, Bangkhae Bangkok Thailand 10160 Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - November 18, 2009 Category: Gastroenterology Tags: International Journal of colorectal Disease Source Type: journals

Can the 2-13C-uracil breath test be used to predict the effect of the antitumor drug S-1?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results suggest that the anticancer effect of S-1 can be predicted by performing UrBT 3 h after the initial oral S-1 administration. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1168-5Authors Yukimoto Ishii, Nihon University School of Medicine Department of Surgery, Nerima Hikarigaoka Hospital 2-11-1 Hikarigaoka Nerima-ku Tokyo 179-0072 JapanShigeru Suzuki, Nihon University School of Medicine Division of Genetic and Genomic Research, Medical Research Center Itabashi-ku Tokyo 173-8610 JapanYasuo Takahashi, Nihon University School of Medicine Division ...
Source: Cancer Chemotherapy and Pharmacology - November 18, 2009 Category: Cancer & Oncology Tags: cancer Chemotherapy and Pharmacology Source Type: journals

Detection of hypoxia in microscopic tumors using 131I-labeled iodo-azomycin galactopyranoside (131I-IAZGP) digital autoradiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion 131I-IAZGP can detect hypoxia in microscopic tumors. Microscopic tumors are useful models for the validation of hypoxia radiotracers, and digital autoradiography is an appropriate technique for studying the distribution of hypoxia radiotracers in microscopic tumors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1310-yAuthors Xiao-Feng Li, Memorial Sloan-Kettering Cancer Center Department of Medical Physics New York NY USAXiaorong Sun, Memorial Sloan-Kettering Cancer Center Department of Medical Physics New York NY USAYuanyuan Ma, Memorial Sloan-Kettering Canc...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 18, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Asbestos-related cancers among 28,300 military servicemen in the Royal Norwegian NavyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study focus on the incidence of asbestos-related cancers among 28,300 officers and enlisted servicemen in the Royal Norwegian Navy. Until 1987, asbestos aboard the vessels potentially caused exposure to 11,500 crew members.Standardized incidence ratios (SIR) were calculated for malignant mesothelioma, lung cancer, and laryngeal, pharyngeal, stomach, and colorectal cancers according to service aboard between 1950 and 1987 and in other Navy personnel.Increased risk of mesothelioma was seen among engine room crews, with SIRs of 6.23 (95% CI = 2.51-12.8) and 6.49 (95% CI = 2.11-15.1) for personnel who served less than 2 y...
Source: American Journal of Industrial Medicine - November 18, 2009 Category: Occupational Health Authors: Leif Aage Strand, Jan Ivar Martinsen, Vilhelm F. Koefoed, Jan Sommerfelt-Pettersen, Tom Kristian Grimsrud Source Type: journals

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative statesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states. (Source: BMC Cancer)
Source: BMC Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Aaron SarverAmy FrenchPedro BorralhoVenugopal ThayanithyAnn ObergKevin SilversteinBruce MorlanShaun RiskaLisa BoardmanJulie CunninghamSubbaya SubramanianLiang WangTom SmyrkCecilia RodriguesStephen ThibodeauClifford Steer Source Type: journals

Systemic hernial disease protects against cancer: an hypothesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Research by herniologists from around the world has shown that abdominal defects, in the adult, are not caused by wear and tear but systemic hernial disease (herniosis), a disorder of connective tissue which affects the extracellular matrix (ECM). Wound healing may be affected, leading to recurrences after hernia repair or primary incisional herniation. Women with genitourinary prolapse show signs of herniosis in the pelvis. Diverticulosis coli, commonly seen in the elderly, like hernia, was once attributed to stress and strain from constipation. It is now suspected that herniosis weakens the coloni...
Source: Hernia - November 17, 2009 Category: Sports Medicine Tags: Hernia Source Type: journals

Poniard Pharmaceuticals Announces Updated Positive Clinical Data from Phase 2 Trial of Picoplatin in Colorectal Cancer and New Phase 1 Cardiac Safety Trial ResultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
- Data Presented at AACR-NCI-EORTC's "Molecular Targets and Cancer Therapeutics" International Conference - SOUTH SAN FRANCISCO, Calif., Nov. 17 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (NASDAQ:PARD) today announced updated... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - November 17, 2009 Category: Pharmaceuticals Source Type: clinical trials

Patents on breast cancer genes are illegal and stymie research, say scientistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 17, 2009 Category: Journals (General) Authors: Lenzer, J. Tags: Immunology (including allergy), Breast cancer, colon cancer, Molecular biology, Asthma NEWS Source Type: journals

Acute lower gastrointestinal haemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 17, 2009 Category: Journals (General) Authors: Edwards, A. J, Maskell, G. F Tags: Endoscopy, GI bleeding, Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, colon cancer, Interventional cardiology, Radiology, Surgical diagnostic tests, Gastrointestinal surgery, General surgery, Radiology (diagnostics), Resuscita Source Type: journals

Poniard Pharmaceuticals Announces Updated Positive Clinical Data From Phase 2 Trial Of Picoplatin In Colorectal Cancer And New Phase 1 Cardiac Safety Trial ResultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ) today announced updated clinical data from its randomized, controlled Phase 2 trial of picoplatin in patients with metastatic colorectal cancer (CRC). (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - November 17, 2009 Category: Pharmaceuticals Source Type: news

'Cross-talk' mechanism contributes to colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 17, 2009 Category: Science Source Type: news

Darcus Howe: My battle with prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surviving a disease where the UK death rate for West Indian men far outstrips that of whitesOn the day of my diagnosis, in April 2007, I kept an appointment at the urology clinic at Kings College Hospital in south London. The place was well known to me. A cricketing past had yielded several injuries over the years and the accident and emergency department became my second home. Mrs Howe is a senior manager there and my last two children, accident prone as they were, also visited A&E on several occasions.Kings College is a spit away from Brixton where I lived for more than 30 years. Not once have I entered its gates without...
Source: Guardian Unlimited Science - November 17, 2009 Category: Science Tags: Prostate cancer Health & wellbeing Life and style Science The Guardian Features Source Type: news

Does Specialized Surgical Training Increase Lymph Node Yield in Colon Cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The number of lymph nodes analyzed in specimens from patients undergoing resection for colon cancer has diagnostic and therapeutic importance. Low lymph node number is a risk factor for poor survival, particularly in patients with Stage II and Stage III disease. (Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Facile Synthesis and In-Vitro Antitumor Activity of Some Pyrazolo[3,4-b]pyridines and Pyrazolo[1,5-a]pyrimidines Linked to a Thiazolo[3,2-a]benzimidazole MoietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The key precursor E-3-(N,N-dimethylamino)-1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)prop-2-en-1-one 4 was synthesized in good yield using Gold's reagent. The reaction of enaminone 4 with 5-amino-3-aryl-1-phenylpyrazoles 5a, b in refluxing acetic acid in the presence of sulphuric acid, yielded pyrazolo[3,4-b]pyridines 7a, b. Similarly, pyrazolo[1,5-a]pyrimidines 10a, b and 14a-f were prepared by reaction of enaminone 4 with 5-amino-1H-pyrazoles 8a, b and 12a-f, respectively. The structure of pyrazolo[1,5-a]pyrimidine 10b was determined by X-ray diffraction. The synthesized compounds were tested for their in-vitro antitumo...
Source: Archiv der Pharmazie - November 17, 2009 Category: Drugs & Pharmacology Authors: Hatem A. Abdel-Aziz, Tamer S. Saleh, Heba S. A. El-Zahabi Source Type: journals

Are patients with non-muscle-invasive bladder cancer a suitable population for a lung cancer screening trial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To estimate the relative risk of developing a second primary neoplasm, in particular lung cancer, after having non-muscle-invasive bladder cancer (NMIBC). Patients were included in the study if they had developed NMIBC between 1995 and 2003. All clinical data were extracted from the medical records of our institution's database. The interval between neoplasms, smoking habits, histological subtypes and survival were also analysed. Patient follow-up was [ge]5 years. We found 231 patients with NMIBC, 39 of which had a second primary neoplasm: 10 lung cancer, one pancreas, one gastric, one pharynx, one liver, one parathyroid, ...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Javier del Rey, José Placer, Felip Vallmanya, Núria Pujol, Esther Prat, Rosa Miró, Antoni Gelabert Source Type: journals

Nonoperative Management of Patients With a Diagnosis of High-grade Small Bowel Obstruction by Computed Tomography [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients with HGSBO by CT can be managed safely with nonoperative therapy; however, they have a significantly higher rate of recurrence requiring readmission or operation within 5 years. (Source: Archives of Surgery)
Source: Archives of Surgery - November 16, 2009 Category: Surgery Authors: Rocha, F. G., Theman, T. A., Matros, E., Ledbetter, S. M., Zinner, M. J., Ferzoco, S. J. Tags: Neurology, Functional Imaging, Radiologic Imaging, Surgery, Surgical Interventions, colorectal Surgery, Gastrointestinal/ Upper Foregut, Surgery, Other, Diagnosis, Computed Tomography, PET/ SPECT Imaging Original Article Source Type: journals

Death After Colectomy: It's Later Than We Think [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The 30-day mortality significantly underreports the true risk of death after CRS. The 90-day mortality rate should be included as a standard outcome measure after CRS because it serves as a better estimation of risk for counseling patients. (Source: Archives of Surgery)
Source: Archives of Surgery - November 16, 2009 Category: Surgery Authors: Visser, B. C., Keegan, H., Martin, M., Wren, S. M. Tags: Oncology, colon cancer, Surgery, Surgical Interventions, colorectal Surgery, Prognosis/ Outcomes Original Article Source Type: journals

Evidence Scarce to Support RF Ablation of Colorectal CA Metastases in the LiverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Radiofrequency (RF) ablation is widely used to treat hepatic metastases from colorectal cancer, but an American Society of Clinical Oncology evidence review warns there is no proof of the efficacy and efficiency of this approach. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: Hematology-Oncology Source Type: news