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1492 records returned

Obesity and Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precu...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Mini-Review Source Type: journals

Peutz-Jeghers syndrome: diagnostic and therapeutic approach.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Peutz-Jeghers syndrome (PJS) is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280,000 individuals. PJS predisposes sufferers to various malignancies (gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors). Bleeding, obstruction and intussusception are common complications in patients with PJS. Double balloon enteroscopy (DBE) allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgen...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Kopacova M, Tacheci I, Rejchrt S, Bures J Tags: World J Gastroenterol Source Type: journals

Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Some epidemiologic studies have indicated that uterine cancer risk may be increased after use of fertility drugs. To further assess this association, the authors used data from a large cohort of 54,362 women diagnosed with infertility who were referred to Danish fertility clinics between 1965 and 1998. In a case-cohort study, rate ratios and 95% confidence intervals were used to assess the effects of 4 groups of fertility drugs on overall risk of uterine cancer after adjustment for potentially confounding factors. Through mid-2006, 83 uterine cancers were identified. Ever use of any fertility drug was not associated with u...
Source: American Journal of Epidemiology - November 18, 2009 Category: Epidemiology Authors: Jensen, A., Sharif, H., Kjaer, S. K. Tags: RESEARCH-ARTICLE Source Type: journals

Anesthetic management of a patient with hyperthyroidism due to hydatidiform moleemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report here the perioperative management of hyperthyroidism due to hydatidiform mole. A 53-year-old woman underwent emergency surgery due to suspicion of hydatidiform mole. Tachycardiac atrial fibrillation was detected by electrocardiography at the preoperative examination. No abnormalities were found in blood count, coagulation, biochemical tests, chest radiographs, or respiratory function. General anesthesia with nitrous oxide, oxygen, and sevoflurane, combined with fentanyl and 1% mepivacaine, was administered intermittently from an epidural catheter. Intraoperative events included hypotension and tachycardia, a...
Source: Journal of Anesthesia - November 17, 2009 Category: Anesthesiology Tags: Journal of Anesthesia Source Type: journals

The endometrium--from estrogens alone to TSECs.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article reviews publications dating back more than a century describing investigations of the endometrium, including those examining the relationship between endometrial hyperplasia and carcinoma, the influence of estrogens on the endometrium, and strategies for protecting the endometrium from unopposed estrogen stimulation. Endometrial hyperplasia and carcinoma studies date from before 1900. The influence of endogenous estrogens on the endometrium became evident with observations of endometrial hyperplasia and/or carcinoma in women with estrogen-secreting tumors or polycystic ovarian disease. Later, observational stu...
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Pickar JH Tags: Climacteric Source Type: journals

Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: This study provides evidence that the risk of developing gynecological cancers with E/D use of several months to a few years is similar to the risks of developing gynecological cancer without HRT or use of other HRT. PMID: 19905903 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Schneider C, Jick SS, Meier CR Tags: Climacteric Source Type: journals

Endometrial cancer.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Endometrial cancer is the leading cause of gynecologic cancer in the United States. Etiologically, endometrial carcinoma usually results from unopposed estrogen stimulation of the endometrium, although non-estrogen-related forms occur as well. The most common presentation of endometrial cancer is postmenopausal bleeding. A variety of diagnostic modalities are available to aid in the detection of the disease, each with its own strengths and limitations. These modalities include endometrial biopsy, ultrasonography, saline infusion sonography, and hysteroscopy. A definitive diagnosis requires pathologic confirmation via e...
Source: American Family Physician - November 13, 2009 Category: Primary Care Authors: Buchanan EM, Weinstein LC, Hillson C Tags: Am Fam Physician Source Type: journals

Macrophage migration inhibitory factor expression in cervical canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  MIF has been shown to promote tumor immune escape mechanisms in other cancer entities, which makes it an interesting target for cancer therapy, given the known significance of immune mechanisms for uterine cervical cancer. The overexpression of MIF on the protein and mRNA level, as well as its secretion by cervical cancer cells points to a critical role of the protein for the pathogenesis of uterine cervical cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0702-5Authors Mathias Krockenberger, University of Wuerzburg Department of Obstetrics and Gynecology ...
Source: Journal of Cancer Research and Clinical Oncology - November 13, 2009 Category: Cancer & Oncology Tags: Journal of cancer Research and Clinical Oncology Source Type: journals

p53 regulates LIF expression in human medulloblastoma cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Medulloblastomas are highly malignant, poorly differentiated childhood tumours arising in the cerebellum. These tumors rarely lose TP53, which is the most commonly mutated gene in cancer. Recent work has shown that the basal level of p53 plays an important role in maternal reproduction by maintaining the expression of LIF in the uterus. Since LIF can maintain the undifferentiated state of stem cells we set out to ask if p53 regulates LIF in the human medulloblastoma cell lines DAOY and D283MED. We also used p53−/− and p53+/+ isogenic HCT116 colorectal carcinoma cell lines, already reported ...
Source: Journal of Neuro-Oncology - November 12, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Estrogens, MSI and Lynch syndrome-associated tumors.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Estrogens play a major role in the biology of hormone-responsive tissues but also in the normal physiology of various non-typical hormone-responsive tissues. In disease, estrogens have been associated with tumor development, in particular with tumors such as breast, endometrium, ovary and prostate. In this paper we will review the molecular mechanisms by which estrogens are involved in cancer development, with a special focus in Lynch syndrome related neoplasia. Further, we discuss the role estrogens might have on cell proliferation and apoptosis, how estrogens metabolites can induce DNA damage and we discuss a possibl...
Source: Biochimica et Biophysica Acta - November 7, 2009 Category: Biochemistry Authors: Ferreira AM, Westers H, Albergaria A, Seruca R, Hofstra RM Tags: Biochim Biophys Acta Source Type: journals

Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2 [Gynecologic Cancer]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Laparoscopic surgical staging for uterine cancer is feasible and safe in terms of short-term outcomes and results in fewer complications and shorter hospital stay. Follow-up of these patients will determine whether surgical technique impacts pattern of recurrence or disease-free survival. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Walker, Piedmonte, Spirtos, Eisenkop, Schlaerth, Mannel, Spiegel, Barakat, Pearl, Sharma Tags: Diagnosis & Staging Gynecologic cancer Source Type: journals

Research Conducted At Johns Hopkins University Has Updated Our Knowledge About Endometrial Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Uterine serous carcinomas typically have a characteristic morphology (papillary architecture, high-grade nuclei) and immunoprofile (diffuse/strong p53 expression, loss of hormone receptor expression) that distinguish them from most endometrial endometrioid carcinomas. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 6, 2009 Category: Cancer & Oncology Source Type: news

Predictive Value of FIGO and AJCC Staging Systems in Patients With Uterine Leiomyosarcomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Neither the FIGO nor the AJCC system adequately classifies ULMS patients into clinically meaningful prognostic groups. Background: Cancer staging systems aim to identify patient cohorts with different... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - November 5, 2009 Category: Cancer & Oncology Source Type: journals

A. Eugene Washington appointed as dean of the David Geffen School of Medicine and Vice Chancellor of Health Sciences at UCLAemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Message to UCLA administrative officers, deans, department chairs, directors, vice chancellors and faculty of the medical echool and medical sciences from Scott Waugh, executive vice chancellor and provost:   Dear Colleagues:   I am very pleased to inform you that Chancellor Block and I have proposed for UC Regents’ approval the appointment of A. Eugene Washington as dean of the David Geffen School of Medicine and vice chancellor of health sciences at UCLA, effective February 1, 2010.   Dr. Washington currently serves as executive vice chancellor & provost and professor of gynecolog...
Source: UCLA Newsroom: Health Sciences - November 4, 2009 Category: Universities & Medical Training Source Type: organizations

Inducible heat shock protein 70 enhances HPV31 viral genome replication and virion production during the differentiation-dependent life cycle in human keratinocytes.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study we carry out analyses in the natural host epithelial tissues to assess the role of inducible HSP70 (HSP70i) in the HPV infectious life cycle. For these studies we used the organotypic (raft) culture system to recapitulate the full viral life cycle of the high-risk HPV31. Upon heat shock of HPV31 infected organotypic tissues, we find high and sustained expression of HSP70i coincident with enhanced HPV genome replication and virion production. Whereas there is no clear effect on L1 expression levels, we find HSP70i and L1 interact and HSP70i colocalizes with and enhances the nuclear localization of L1 in differ...
Source: Virus Research - November 4, 2009 Category: Virology Authors: Song H, Moseley PL, Lowe SL, Ozbun MA Tags: Virus Res Source Type: journals

RBSP3 is frequently altered in premalignant cervical lesions: Clinical and prognostic significanceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
To understand the importance of frequent deletion of 3p22.3 in cervical carcinogenesis, alterations (deletion/methylation/expression) of the candidate genes STAC, MLH1, ITGA9, and RBSP3, located in the region, were analyzed in 24 cervical intraepithelial neoplasia (CIN) and 137 uterine cervical carcinoma (CACX) samples. In CIN, RBSP3 deletion (48%) and methylation (26%) were high compared with the other genes (4-9%). In CACX, alterations of these genes were as follows: deletion: STAC (54%) > MLH1 (46%) > RBSP3 (45%) > ITGA9 (41%), methylation: RBSP3 (25%) > ITGA9 (24%) > STAC (19%) > MLH1 (13%). Overall, alterations of RBS...
Source: Genes, Chromosomes and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Sraboni Mitra, Dipanjana Mazumder Indra, Nilanjana Bhattacharya, Ratnesh K. Singh, Partha S. Basu, Ranajit K. Mondal, Anup Roy, Eugene R. Zabarovsky, Susanta Roychoudhury, Chinmay K. Panda Source Type: journals

A case with spontaneous bladder rupture mimicking acute kidney injury.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a case with spontaneous bladder rupture mimicking acute kidney injury forty years after postoperative pelvic irradiation for uterine cancer. PMID: 19863882 [PubMed - in process] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 1, 2009 Category: Urology & Nephrology Authors: Horino T, Okazaki M, Nishikawa H, Takao T, Taniguchi Y, Morita T, Terada Y, Tags: Clin Nephrol Source Type: journals

Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Study.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Some epidemiologic studies have indicated that uterine cancer risk may be increased after use of fertility drugs. To further assess this association, the authors used data from a large cohort of 54,362 women diagnosed with infertility who were referred to Danish fertility clinics between 1965 and 1998. In a case-cohort study, rate ratios and 95% confidence intervals were used to assess the effects of 4 groups of fertility drugs on overall risk of uterine cancer after adjustment for potentially confounding factors. Through mid-2006, 83 uterine cancers were identified. Ever use of any fertility drug was not associated wi...
Source: Am J Epidemiol - November 1, 2009 Category: Epidemiology Authors: Jensen A, Sharif H, Kjaer SK Tags: Am J Epidemiol Source Type: journals

Coffee may lower endometrial cancer riskemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
NEW YORK (Reuters Health) - Women dread a diagnosis of endometrial cancer, but those who drink at least two cups of caffeinated coffee a day may have a lower risk for this cancer of cells lining the uterus. (Source: Reuters: Health)
Source: Reuters: Health - October 30, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

Coffee May Lower Endometrial Cancer Riskemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Women dread a diagnosis of endometrial cancer, but those who drink at least two cups of caffeinated coffee a day may have a lower risk for this cancer of cells lining the uterus. Source: Reuters Health Related MedlinePlus Topics: Caffeine, Uterine Cancer (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 30, 2009 Category: Consumer Health News Source Type: consumer

Breast cancer with synchronous massive metastasis in the uterine cervix: a case report and review of the literatureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Discussion  Genital tract metastases in patients with known breast carcinoma can present with abnormal vaginal bleeding, but they often are asymptomatic. Therefore, only strict gynecological surveillance of these patients can permit early detection of these secondary lesions. Aggressive treatment of isolated cervical metastasis should be performed when feasible; otherwise, systemic chemotherapy with taxane could be sufficient in increasing survival. It should be emphasized that, in most cases, only accurate immunohistochemical investigation, particularly if performed on the primary lesion as well, can solve d...
Source: Archives of Gynecology and Obstetrics - October 29, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

A Role for BRCA1 in Uterine Leiomyosarcomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Uterine leiomyosarcoma (ULMS) is a rare gynecologic malignancy with a low survival rate. Currently, there is no effective treatment for ULMS. Infrequent occurrences of human ULMS hamper the understanding of the initiation and progression of the disease, thereby limiting the ability to develop efficient therapies. To elucidate the roles of the p53 and BRCA1 tumor suppressor genes in gynecologic malignancies, we generated mice in which p53 and/or BRCA1 can be conditionally deleted using anti-Müllerian hormone type II receptor (Amhr2)–driven Cre recombinase. We showed that conditional deletion of p53 in mice result...
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Xing, D., Scangas, G., Nitta, M., He, L., Xu, X., Ioffe, Y. J.M., Aspuria, P.-J., Hedvat, C. Y., Anderson, M. L., Oliva, E., Karlan, B. Y., Mohapatra, G., Orsulic, S. Tags: Priority Reports Source Type: journals

Evidence for Cancer Stem Cells in Human Endometrial Carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Emerging evidence indicates that the highly regenerative human endometrium harbors rare populations of epithelial progenitor cells. In tumors of other regenerative epithelial tissues, rare cancer stem cells (CSC) have been identified that may have originated from normal epithelial stem/progenitor cells. We hypothesized that CSC are responsible for epithelial neoplasia associated with endometrial carcinoma, the most common gynecologic malignancy in women. Stem cell characteristics of single cells isolated from endometrial carcinoma tissues from women ages 62 ± 11.8 years (n = 34) were assessed. Twenty-five of 28 endo...
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Hubbard, S. A., Friel, A. M., Kumar, B., Zhang, L., Rueda, B. R., Gargett, C. E. Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

Expression of nodal signalling components in cycling human endometrium and in endometrial canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: The expression of Nodal in normal and malignant endometrial cells that lack Lefty strongly supports an important role for this embryonic morphogen in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 29, 2009 Category: Endocrinology Authors: Irene PapageorgiouPeter NichollsFang WangMartin LackmannYogeshwar MakanjiLois SalamonsenDavid RobertsonCraig Harrison Source Type: journals

Titrimetric immunohistochemical evaluation of DNA hypomethylation in uterine tumoursemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: A simple titrimetric immunohistochemical method has been developed for quantitative evaluation of ligands. This method should be further employed in follow-up studies, in order to establish the prognostic value of DNA hypomethylation in uterine cancer. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Wolk, M, Martin, J E Tags: Immunology (including allergy), Gynecological cancer Short reports Source Type: journals

Uganda: Keep Focus On Cervical Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Association of Obstetrics and Gynaecologists of Uganda last week raised a red flag that the management, administration, care and treatment for fibroids (a non-cancerous growth of the muscle of uterus, typically occurring in women during the reproductive years) and cervical cancer in Uganda's health infrastructure is continually wanting. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 26, 2009 Category: African Health Source Type: news

Mesothelioma, lung cancer and nutritionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(NaturalNews) Mesothelioma doesn't have to be fatal. This rare form of lung cancer has long been feared by workers exposed to asbestos in their work environments, and much of that fear is justified: This form of cancer can be deadly. But it doesn't always have to be.There are natural ways to greatly extend life, even for those suffering from mesothelioma. Most are based on nutritional therapies, as you'll see below. It may seem counterintuitive to suppose that nutrition could play a role in a disease caused by a physical substance (asbestos), but in fact, antioxidants and phytonutrients that support healthy cellular protec...
Source: NaturalNews.com - October 24, 2009 Category: Consumer Health Advice Source Type: news

Clinical research Transvaginal doppler sonography for assessment the response to radiotherapy in locally advanced squamous cervical cancer: a preliminary studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: TVS is useful for estimation of uterine cervix during radiation therapy due to locally advanced cervical cancer, but its usefulness in prediction of progression of the cancer is rather low. The value of the assessment of RI in descending branches of uterine arteries in monitoring the treatment of the cervical cancer was not confirmed. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

British scientists step closer to womb transplantsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Breakthrough could offer alternative to surrogacy but extra funding is needed to complete human womb transplant studiesBritish scientists believe they are a step closer to carrying out the first successful womb transplant.They have worked out how to transplant a womb with a good blood supply which could mean it lasts long enough to carry a pregnancy to term.A breakthrough would offer an alternative to surrogacy or adoption for women whose own wombs have been damaged by diseases such as cervical cancer.Around 15,000 women of childbearing age are currently living with a womb that does not work or were born without one.Richar...
Source: Guardian Unlimited Science - October 22, 2009 Category: Science Tags: Fertility problems Life and style Science Pregnancy Medical research UK news Health & wellbeing Organ donation Society guardian.co.uk Source Type: news

Scientists closer to womb transplantsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Breakthrough could offer alternative to surrogacy but extra funding is needed to complete human womb transplant studiesBritish scientists believe they are a step closer to carrying out the first successful womb transplant.They have worked out how to transplant a womb with a good blood supply which could mean it lasts long enough to carry a pregnancy to term.A breakthrough would offer an alternative to surrogacy or adoption for women whose own wombs have been damaged by diseases such as cervical cancer.Around 15,000 women of childbearing age are currently living with a womb that does not work or were born without one.Richar...
Source: Guardian Unlimited Science - October 22, 2009 Category: Science Tags: Fertility problems Life and style Science Pregnancy Medical research UK news Health & wellbeing Organ donation Society guardian.co.uk Source Type: news

Dr. Weil was right: Astragalus herb really helps fight the flu (influenza)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(NaturalNews) The FTC and FDA are terrorizing Dr. Andrew Weil over his true statements about the immune-boosting properties of astragalus. According to the FDA, astragalus has no antiviral or antibacterial properties whatsoever and is of absolutely no use in the human body. Sound bizarre?I thought so too. That's why I asked NaturalNews researchers to assemble a collection of statements in support of Dr. Weil's astragalus statements. This medicinal herb does, indeed, boost healthy immune function and offer protection against influenza. And because it's a multifaceted, complex plant-based medicine, it's not outsmarted by one...
Source: NaturalNews.com - October 22, 2009 Category: Consumer Health Advice Source Type: news

Racial disparities for uterine corpus tumorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
No abstract. (Source: Cancer)
Source: Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Jason D. Wright Source Type: journals

Clinical results and histological changes following preoperative interventional treatment of the aggressive subtype of endometrial canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  The preoperative intra-arterial chemotherapy and embolization can improve the operability of resection in patients with aggressive subtype of endometrial carcinoma, reduce the expression of PCNA, adjust malignancy of endometrial carcinoma, and improve prognosis. Content Type Journal ArticleDOI 10.1007/s10330-009-0096-5Authors Yongxiu Qiu, Zhongshan Hospital of Traditional Chinese Medicine Department of Gynecology and Obstetrics Zhongshan 528400 ChinaCunlin Chen, The Southern Medical University Department of Gynecology and Obsterics, Nanfang Hospital Guangzhou 510000 ChinaYili Wei, Zhongshan ...
Source: The Chinese-German Journal of Clinical Oncology - October 21, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Tamoxifen and arrhythmiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Tamoxifen is an orally active selective estrogen receptor modulator that is used in the treatment of breast cancer and is currently the world’s largest selling drug for that purpose. However, it has some side effects including hot flashes, menstrual irregularity, vaginal discharges, uterine bleeding, uterine endometrial cancer, hypercoagulability, steatosis hepatis, risk of trombembolism. Long-term data from clinical trials have failed to demonstrate a cardioprotective effect and beneficial effects on serum lipid profiles. Arrhythmia secondary to tamoxifen is very rare. Content Type Journal Art...
Source: Medical Oncology - October 21, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Family history of cancer and malignant germ cell tumors in children: A report from the Children’s Oncology Groupemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Family history of testicular cancer is an established risk factor for adult testicular germ cell tumors (GCT). We evaluated the association between family history of cancer and pediatric GCT in a Children’s Oncology Group case–control study that included 274 GCT cases (195 female and 79 male) diagnosed <age 15 years and 418 controls frequency matched to cases on sex and age. Family history data were collected through telephone interviews with biological mothers and fathers and unconditional logistic regression was used to evaluate associations with GCT adjusting for potential confounders...
Source: Cancer Causes and Control - October 21, 2009 Category: Cancer & Oncology Tags: cancer Causes and Control Source Type: journals

Forgotten node: A case report.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Sister Mary Joseph nodule or node refers to a palpable nodule bulging into the umbilicus and is usually a result of a malignant cancer in the pelvis or abdomen. Traditionally it has been considered a sign of ominous prognosis. Gastrointestinal malignancies, most commonly gastric, colon and pancreatic cancer account for about 52% of the underlying sources. Gynecological cancers, most commonly ovarian and uterine cancers account for about 28% of the sources. PMID: 19842232 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 20, 2009 Category: Gastroenterology Authors: Fratellone PM, Holowecki MA Tags: World J Gastroenterol Source Type: journals

Free to Breathe - Walk Anywhere for Lung Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
I'm not always in the right place at the right time. Though I love doing anything to raise awareness and support those touched by lung cancer - I can't always get there. (And I think I wore out my excuse at home that I have to build up my frequent flyer miles...) No problem. I can walk anywhere on November 7th. The Free to Breathe ® National Run/Walk for lung cancer will be held on November 7th 2009. No matter where you live, if shortness of breath limits your activity, or if you just prefer to march (or walk or run) to your own drummer, you can join others around the country to raise awareness about lung cancer. At thi...
Source: About.com Lung Cancer - October 20, 2009 Category: Cancer & Oncology Source Type: consumer

High Dose Folate And B Vitamin Supplements Increase Uterine Cancer Riskemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Women who take large amounts of folate, vitamin B2, B6 or B12 supplements may be increasing their risk of uterine cancer, according to research presented at the 16th International Meeting of the European Society of Gynaecological Oncology (ESGO) in Belgrade, Serbia, 11-14 October 2009. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 18, 2009 Category: Consumer Health News Tags: cancer / Oncology Source Type: news

Low Initial Human Papilloma Viral Load Implicates Worse Prognosis in Patients With Uterine Cervical Cancer Treated With Radiotherapy [Gynecologic Cancer]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Our data suggest that HPV viral load is a strong independent prognostic factor for DFS. HPV type 18 showed a significant relationship with poor radiotherapy outcome in univariate analysis, but not in multivariate analysis. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Kim, Park, Nam, Roh, Lee, Kim, Shin, Lee, Kong, Seong, Han, Lee, Cho, Park Tags: Radiation, Translational Oncology, Radiation Oncology, Gynecologic, cancer Biomarkers Gynecologic cancer Source Type: journals

Prevalence of prognostic factors for cancer of the uterine cervix after radical hysterectomy.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: The most prevalent prognostic factors were the presence of lymph node metastasis, tumor size and surgical margin involvement. PMID: 19820876 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - October 15, 2009 Category: Journals (General) Authors: Tavares MB, Sousa RB, Silva TO, Moreira LA, Silva LT, Tavares CB, Vieira SC Tags: Sao Paulo Med J Source Type: journals

Novel imaging modalities in gynecologic canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article reviews novel imaging modalities in gynecologic cancer, with a special focus on FDG-PET/CT. Content Type Journal ArticleDOI 10.1007/s11912-009-0063-xAuthors Rebecca A. BrooksMatthew A. Powell, Washington University School of Medicine Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Box 8064 Saint Louis MO 63110 USA Journal Current Oncology ReportsOnline ISSN 1534-6269Print ISSN 1523-3790 Journal Volume Volume 11 Journal Issue Volume 11, Number 6 / November, 2009 (Source: Current Oncology Reports)
Source: Current Oncology Reports - October 13, 2009 Category: Cancer & Oncology Tags: Current Oncology Reports Source Type: journals

Association of new-onset breast tenderness after initiation of estrogen plus progestin therapy and breast cancer riskemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Arch Internal Med Area: News According to research published in the Archives of Internal Medicine, new-onset breast tenderness during conjugated equine estrogens plus medroxyprogesterone therapy was associated with increased breast cancer risk.   Researchers evaluated data from the Women's Health Initiative Estrogen + Progestin Trial, which randomised post-menopausal women with an intact uterus to receive daily conjugated equine estrogens, 0.625 mg, plus medroxyprogesterone acetate, 2.5 mg (n = 8506), or placebo (n = 8102). At baseline and annually, participants underwent mammography and clinical breast e...
Source: NeLM - News - October 12, 2009 Category: Drugs & Pharmacology Source Type: organizations

Standards of Care Evolving for Uncommon Uterine Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Uterine papillary serous carcinoma, the less common form of endometrial cancer, causes a disproportionate number of deaths, and more clinical trials are needed to develop evidence-based management strategies, according to a literature review in the October issue of Gynecologic Oncology. (Source: Modern Medicine)
Source: Modern Medicine - October 12, 2009 Category: Journals (General) Source Type: info

[Uterine sarcoma associated with tamoxifen use after breast cancer: Review of the pathogenesis.]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Tamoxifen is widely used in the breast cancer treatment. Its side effects on the endometrium are well-known, but more and more worse prognosis uterine sarcoma are described. Based on recent literature review, the cause and effect chain between tamoxifen and uterine sarcoma is argued, which confirms that a risk exists as from 2 years of treatment, a cumulative dose of 15g, and that malignant mixed mesodermal tumours appear to be the most frequent. PMID: 19833452 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - October 12, 2009 Category: OBGYN Authors: Homer L, Muller M, Dupré PF, Lucas B, Pradier O Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: journals

ORIGINAL INVESTIGATION: New-Onset Breast Tenderness After Initiation of Estrogen Plus Progestin Therapy and Breast Cancer Riskemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  New-onset breast tenderness during conjugated equine estrogens plus medroxyprogesterone therapy was associated with increased breast cancer risk. The sensitivity and specificity of the association between breast tenderness and breast cancer were similar in magnitude to those of the Gail model. Trial Registration  clinicaltrials.gov Identifier: NCT00000611 (Source: Archives of Internal Medicine)
Source: Archives of Internal Medicine - October 12, 2009 Category: Internal Medicine Authors: Crandall, C. J., Aragaki, A. K., Chlebowski, R. T., McTiernan, A., Anderson, G., Hendrix, S. L., Cochrane, B. B., Kuller, L. H., Cauley, J. A. Tags: Oncology, Breast cancer, Women's Health, Menopause, Drug Therapy, Adverse Effects Original Investigation Source Type: journals

New-Onset Breast Tenderness After Initiation of Estrogen Plus Progestin Therapy and Breast Cancer Risk [Original Investigation]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  New-onset breast tenderness during conjugated equine estrogens plus medroxyprogesterone therapy was associated with increased breast cancer risk. The sensitivity and specificity of the association between breast tenderness and breast cancer were similar in magnitude to those of the Gail model. Trial Registration  clinicaltrials.gov Identifier: NCT00000611 (Source: Archives of Internal Medicine)
Source: Archives of Internal Medicine - October 12, 2009 Category: Internal Medicine Authors: Crandall, C. J., Aragaki, A. K., Chlebowski, R. T., McTiernan, A., Anderson, G., Hendrix, S. L., Cochrane, B. B., Kuller, L. H., Cauley, J. A. Tags: Oncology, Breast cancer, Women's Health, Menopause, Drug Therapy, Adverse Effects Original Investigation Source Type: journals

Diffusion-weighted imaging in predicting and monitoring the response of uterine cervical cancer to combined chemoradiationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: ADCs may have the potential to be used to predict and monitor the response of uterine cervical cancer to therapy. (Source: Clinical Radiology)
Source: Clinical Radiology - October 12, 2009 Category: Radiology Authors: Y. Liu, R. Bai, H. Sun, H. Liu, X. Zhao, Y. Li Tags: Original Articles Source Type: journals

APC promoter hypermethylation is an early event in endometrial tumorigenesisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The aim of the current study was to investigate the role of promoter methylation of adenomatous polyposis coli (APC) and epithelial cadherin (E-cadherin) genes in endometrial tumorigenesis. The methylation status of both genes was investigated in 43 cases of normal endometrium, 21 simple hyperplasia, 17 atypical hyperplasia, and 86 endometrial carcinoma (EC). Additionally, the methylation pattern of both genes was analyzed in 24 primary ECs and their corresponding metastases. DNA methylation of the APC gene increased from atypical hyperplasia (23.5%) to endometrial carcinoma, reaching its highest level of 77.4% in early st...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Atanas Ignatov, Joachim Bischoff, Tanja Ignatov, Christa Schwarzenau, Thomas Krebs, Doerthe Kuester, Serban D. Costa, Albert Roessner, Andrzej Semczuk, Regine Schneider-Stock Source Type: journals

Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathologyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Women may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are a...
Source: Diagnostic Histopathology - October 12, 2009 Category: Pathology Authors: Ui-Soon Khoo, Dan-Hua Shen, Richard Wing-Cheuk Wong, Annie Nga-Yin Cheung Tags: Mini-Symposium: Pathology of the uterus and Fallopian Tube Source Type: journals