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Bladder Cancer Risks Increase Over Time for SmokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It's well established that cigarette smoking causes bladder cancer, but the influence of smoking history over time has been unclear. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - November 20, 2009 Category: Consumer Health News Source Type: news

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population. (Source: BMC Cancer)
Source: BMC Cancer - November 20, 2009 Category: Cancer & Oncology Authors: Adela CastillejoTrinidad Mata-BalaguerCarla GuarinosMaria-Isabel CastillejoAna Martinez-CantoVictor-Manuel BarberaPaola MontenegroEnrique OchoaRafael LazaroCarmen Guillen-PonceAlfredo CarratoJose Soto Source Type: journals

Multidisciplinary meeting on urological cancers aims to benefit cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(European Association of Urology) Urological cancer patients will benefit greatly if the delivered treatment is the result of a combined effort. Collaboration of experts from various fields is necessary to take cancer-related research and medical practice to the next level. The 2nd European Multidisciplinary Meeting on Urological Cancers -- Embracing Excellence in Prostate, Bladder and Kidney Cancer -- which is to take place on Nov. 27-29, 2009, in Barcelona, brings together urologists, radiologists and medical oncologists by enabling them to share their knowledge and experience. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 19, 2009 Category: Global & Universal Source Type: news

Urinary diversion and morbidity after radical cystectomy for bladder cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The rate of continent urinary diversion after radical cystectomy for bladder cancer varies by patient and provider characteristics. Demonstration of equivalent complication rates, independent of diversion type, may decrease provider reluctance to perform continent reconstructions. The authors sought to determine whether continent reconstructions confer increased complication rates after radical cystectomy.From the Nationwide Inpatient Sample, the authors used International Classification of Disease (ICD-9) codes to identify subjects who underwent radical cystectomy for bladder cancer during 2001-2005. They determined acute...
Source: Cancer - November 18, 2009 Category: Cancer & Oncology Authors: John L. Gore, Hua-Yin Yu, Claude Setodji, Jan M. Hanley, Mark S. Litwin, Christopher S. Saigal, the Urologic Diseases in America Project Source Type: journals

Bladder Cancer Risks Increase Over Time For SmokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: MEMO TO THE MEDIA Source Type: journals

Cigarette Smoking and Bladder Cancer: A New Twist in an Old Saga?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Alberg, A. J., Hebert, J. R. Tags: EDITORIALS Source Type: journals

Are Smokers Now at Higher Risk of Bladder Cancer? Are Changes in Cigarettes To Blame?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Tuma, R. S. Tags: NEWS Source Type: journals

StatBite: A Look at Bladder Cancer in the United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Tags: NEWS Source Type: journals

A Case-Control Study of Smoking and Bladder Cancer Risk: Emergent Patterns Over TimeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Smoking-related risks of bladder cancer appear to have increased in New Hampshire since the mid-1990s. Based on our modeling of pack-years and intensity, smoking fewer cigarettes over a long time appears more harmful than smoking more cigarettes over a shorter time, for equal total pack-years of cigarettes smoked. (Source: JNCI)
Source: JNCI - November 17, 2009 Category: Cancer & Oncology Authors: Baris, D., Karagas, M. R., Verrill, C., Johnson, A., Andrew, A. S., Marsit, C. J., Schwenn, M., Colt, J. S., Cherala, S., Samanic, C., Waddell, R., Cantor, K. P., Schned, A., Rothman, N., Lubin, J., Fraumeni, J. F., Hoover, R. N., Kelsey, K. T., Silverman Tags: ARTICLES Source Type: journals

Bladder Cancer Risks Increase Over Time For SmokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Risk of bladder cancer for smokers has increased since the mid-1990s, with a risk progressively increasing to a level five times higher among current smokers in New Hampshire than that among nonsmokers in 2001-2004, according to a new study published online November 16 in the Journal of the National Cancer Institute. (Source: Smoking / Quit Smoking News From Medical News Today)
Source: Smoking / Quit Smoking News From Medical News Today - November 17, 2009 Category: Respiratory Medicine Tags: cancer / Oncology Source Type: news

Bladder Cancer Risks Increase Over Time For SmokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Risk of bladder cancer for smokers has increased since the mid-1990s, with a risk progressively increasing to a level five times higher among current smokers in New Hampshire than that among nonsmokers in 2001-2004, according to a new study published online November 16 in the Journal of the National Cancer Institute. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2009 Category: Consumer Health News Tags: cancer / Oncology Source Type: news

Are patients with non-muscle-invasive bladder cancer a suitable population for a lung cancer screening trial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To estimate the relative risk of developing a second primary neoplasm, in particular lung cancer, after having non-muscle-invasive bladder cancer (NMIBC). Patients were included in the study if they had developed NMIBC between 1995 and 2003. All clinical data were extracted from the medical records of our institution's database. The interval between neoplasms, smoking habits, histological subtypes and survival were also analysed. Patient follow-up was [ge]5 years. We found 231 patients with NMIBC, 39 of which had a second primary neoplasm: 10 lung cancer, one pancreas, one gastric, one pharynx, one liver, one parathyroid, ...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Javier del Rey, José Placer, Felip Vallmanya, Núria Pujol, Esther Prat, Rosa Miró, Antoni Gelabert Source Type: journals

Expression of glutathione-S-transferases isoenzymes and P53 in exfoliated human bladder cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: GST isoenzymes and p53 immunostaining were not found to be markers of malignancy in urinary cytology. PMID: 19926314 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - November 17, 2009 Category: Urology & Nephrology Authors: Oğuztüzün S, Sezgin Y, Yazıcı S, Fırat P, Ozhavzalı M, Ozen H Tags: Urol Oncol Source Type: journals

Smoking-Related Bladder Cancer on the Rise (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Smokers appear to be at nearly four times the risk of bladder cancer than they were in the mid-1990s, possibly stemming from changes to the design and composition of cigarettes in the 1960s and 1970s, a new study found. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 16, 2009 Category: Hematology Source Type: news

Matrix Metalloproteinase Testing Useful for Monitoring Bladder CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The urine matrix metalloproteinase (MMP) level can be used to differentiate disease-free patients from those with recurrent bladder cancer, according to a report in the November issue of The Journal of Urology. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: Urology Source Type: news

Association between smoking, bladder cancer may be increasingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HemOncToday.com)
Source: HemOncToday.com - November 16, 2009 Category: Cancer & Oncology Source Type: info

Non-invasive Methods To Detect Schistosome-based Bladder Cancer: Is The Association Sufficient For Epidemiological Use?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UroToday.com - Urinary schistosomiasis caused by the trematode parasite Schistosoma haematobium is endemic in most of Africa. This infection is one of the world's great neglected diseases and it is a known carcinogen. The parasite is long lived, and causes sustained inflammation in the vesicular veins where the adults live for as long a 10 or 12 years. (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - November 16, 2009 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news

Non-invasive Methods To Detect Schistosome-based Bladder Cancer: Is The Association Sufficient For Epidemiological Use?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UroToday.com - Urinary schistosomiasis caused by the trematode parasite Schistosoma haematobium is endemic in most of Africa. This infection is one of the world's great neglected diseases and it is a known carcinogen. The parasite is long lived, and causes sustained inflammation in the vesicular veins where the adults live for as long a 10 or 12 years. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 16, 2009 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Bladder cancer risks increase over time for smokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Journal of the National Cancer Institute) Risk of bladder cancer for smokers has increased since the mid-1990s, with a risk progressively increasing to a level five times higher among current smokers in New Hampshire than that among nonsmokers in 2001-2004, according to a new study published online Nov. 16 in the Journal of the National Cancer Institute. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: news

CD10 expression in urothelial carcinoma of the bladderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: To date, only a few comparative IHC studies have assessed CD10 expression in urothelial carcinoma of the urinary bladder and this study represents the largest series. Our findings indicate that CD10 expression is strongly correlated with high tumor grade and stage in urothelial carcinoma of the bladder, and that CD10 may be associated with tumor progression in bladder cancer pathogenesis. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Burak BahadirKemal BehzatogluSibel BektasErol BozkurtSukru Ozdamar Source Type: journals

Superficially invasive transitional cell carcinoma of the bladder associated with distant cutaneous metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cutaneous metastases from transitional cell carcinoma of the bladder are rare and most often associated with a deeply invasive primary tumor. This case report describes a 69-year-old male with previously resected superficially invasive primary transitional cell carcinoma of the bladder who presented with distant cutaneous and central nervous system metastases associated with recurrent bladder cancer. In addition, this case highlights the differential diagnosis of metastatic carcinomas that display a CK7/CK20 positive immunophenotype including transitional cell carcinoma, pancreatic carcinoma, cholangiocarcinoma and rare ga...
Source: Journal of Cutaneous Pathology - November 16, 2009 Category: Pathology Authors: Brian L. Swick, Jennifer R.S. Gordon Source Type: journals

Oral agent improves survival in advanced bladder cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A drug that is commonly used to treat lung and colon cancer may prolong survival in patients with invasive bladder cancer, researchers reported at the American College of Surgeons clinical congress in Chicago. (Source: Modern Medicine)
Source: Modern Medicine - November 14, 2009 Category: Journals (General) Source Type: info

An audit of nephroureterectomy for upper tract urothelial carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This is the only study in recent 2 decades to evaluate the necessity of synchronous adrenalectomy in treating localized upper tract urothelial carcinoma. Adrenal-sparing nephroureterectomy seems justified for clinically localized upper tract urothelial carcinoma. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: C.-Y. Huang, S.-D. Chung, S.-M. Wang, C.-H. Liao, M.-K. Lai, K.-H. Huang, Y.-S. Pu, S.-C. Chueh, H.-J. Yu Tags: Original Articles Source Type: journals

The effect of age and gender on bladder cancer: a critical review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While patient age and gender are important factors in the clinical decision-making for treating urothelial carcinoma of the bladder (UCB), there are no evidence-based recommendations to guide healthcare professionals. We review previous reports on the influence of age and gender on the incidence, biology, mortality and treatment of UCB. Using MEDLINE, we searched for previous reports published between January 1966 and July 2009. While men are three to four times more likely to develop UCB than women, women present with more advanced disease and have worse survival rates. The disparity among genders is proposed to be the re...
Source: BJU International - November 13, 2009 Category: Urology & Nephrology Authors: Shahrokh F. Shariat, John P. Sfakianos, Michael J. Droller, Pierre I. Karakiewicz, Siegfried Meryn, Bernard H. Bochner Source Type: journals

Breast regrowth procedure trialled for mastectomy patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human trials to begin of surgical treatment that could allow women to regrow their breasts after a mastectomyScientists have developed a revolutionary surgical treatment that could allow women with cancer to regrow their breasts after a mastectomy.Human trials for the procedure, which scientists hope could replace breast reconstructions and implants, will start within three to six months, it was revealed in Melbourne, Australia. It is likely to be three years before the technique is fully developed, researchers said.The procedure involves inserting a biodegradable chamber into the woman's chest, contoured to match her natu...
Source: Guardian Unlimited Science - November 12, 2009 Category: Science Authors: James Meikle Tags: Medical research cancer Australia Science World news Health Society Plastic surgery Life and style guardian.co.uk Source Type: news

Breast regrowth technique to be testedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human trials to begin of surgical treatment that could allow women to regrow their breasts after a mastectomyScientists have developed a revolutionary surgical treatment that could allow women with cancer to regrow their breasts after a mastectomy.Human trials for the procedure, which scientists hope could replace breast reconstructions and implants, will start within three to six months, it was revealed in Melbourne, Australia. It is likely to be three years before the technique is fully developed, researchers said.The procedure involves inserting a biodegradable chamber into the woman's chest, contoured to match her natu...
Source: Guardian Unlimited Science - November 12, 2009 Category: Science Authors: James Meikle Tags: cancer Medical research Embryos and stem cells Australia Science World news Health Society Plastic surgery Life and style The Guardian Source Type: news

Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nurr1 belongs to a novel class of orphan nuclear receptors (the NR4A family). The authors have previously shown that Nurr1 is important in carcinogenesis. In the current study, they examined the clinicopathologic relevance of expression patterns of Nurr1 in bladder tumors.Nurr1 expression was determined using immunohistochemical staining in a bladder cancer tissue array (145 tumors). Tumors were classified according to Nurr1 protein levels in both cytoplasm and nucleus. Disease-specific survival and recurrence-free survival were investigated by Kaplan-Meier analysis and Cox proportional hazards analysis in multivariate mod...
Source: Cancer - November 12, 2009 Category: Cancer & Oncology Authors: Teruo Inamoto, Bogdan A. Czerniak, Colin P. Dinney, Ashish M. Kamat Source Type: journals

Expression of cell cycle-associated proteins in non-muscle-invasive bladder cancer: Correlation with intravesical recurrence following transurethral resection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the expression patterns of cell cycle-associated proteins in newly diagnosed non-muscle-invasive bladder cancer (NMIBC) to clarify the significance of these proteins as prognostic predictors in 161 consecutive patients undergoing transurethral resection (TUR). Expression levels of 7 cell cycle-associated proteins, including Aurora-A, c-erbB2, cyclin-D1, Ki-67, p21, p27, and p53, in TUR specimens were measured by immunohistochemical staining. Of the 7 proteins, weak expression of p21 was significantly associated with the incidence of intravesical recurrence (P = 0.012). Univariate...
Source: Urologic Oncology - November 12, 2009 Category: Urology & Nephrology Authors: Behnsawy HM, Miyake H, Abdalla MA, Sayed MA, Ahmed AE, Fujisawa M Tags: Urol Oncol Source Type: journals

Targeted therapies in non-muscle-invasive bladder cancer according to the signaling pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
With 300,000 annually new cases worldwide, urothelial-cell carcinoma of the bladder (UCCB) is the second most common urologic neoplasm after prostate carcinoma. Non-muscle-invasive bladder cancer (NMIBC), which is not immediately life-threatening, represents 70% to 80% of these initial cases. Despite optimal treatment (transurethral resection with intravesical chemo- or immunotherapy), 70% of these NMIBC will recur, and 10% to 20% will progress, highlighting the need for a new therapeutic approach. Indeed, the identification of patients at high risk of disease recurrence and progression would be beneficial in predictin...
Source: Urologic Oncology - November 12, 2009 Category: Urology & Nephrology Authors: Wallerand H, Bernhard JC, Culine S, Ballanger P, Robert G, Reiter RE, Ferrière JM, Ravaud A Tags: Urol Oncol Source Type: journals

Reconsider screenings for breast and prostate cancer, experts sayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) According to the American Cancer Society (ACS), breast cancer is the most common cancer in women, affecting over 200,000 women in the U.S. each year and killing more than 40,000. For American men, cancer of the prostate is the type of malignancy that strikes with the greatest frequency.The ACS says an estimated 192,280 men will be diagnosed with the disease in 2009 and around 27,360 men will die from it. Based on the assumption that finding breast and prostate cancers in the earliest stages will make them easier to cure and slash mortality rates, for over twenty years the U.S. medical establishment has pushed...
Source: NaturalNews.com - November 11, 2009 Category: Consumer Health Advice Source Type: news

Apoptosis induction by doxazosin and other quinazoline α1-adrenoceptor antagonists: a new mechanism for cancer treatment?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Doxazosin and related, quinazoline-based α1-adrenoceptor antagonists can induce apoptosis in prostate and various other normal, benign, smooth muscle, endothelial and malignant cells. Such apoptosis-inducing effects occur independently of α1-adrenoceptor antagonism and typically require much high concentrations than those required for receptor occupancy. Several studies have invested efforts towards the elucidation of the molecular mechanisms underlying doxazosin-induced apoptosis. These include various tumor cells, cardiomyocytes, endothelial cells and bladder smooth muscle cells. While the high c...
Source: Naunyn-Schmiedeberg's Archives of Pharmacology - November 10, 2009 Category: Drugs & Pharmacology Tags: Naunyn-Schmiedeberg's Archives of Pharmacology Source Type: journals

Robot-assisted radical cystectomy: intermediate survival results at a mean follow-up of 25 monthsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy. Survival, pathological and demographic data were collected on all patients undergoing RARC for bladder cancer from both Tulane University Medical Center and Mayo Clinic Arizona. Of a total of 80 RARCs we only included those with a follow-up of [ge]6 months from surgery. Survival curves were compared with those from historical series of open cystectomy. Of the 80 patients 59 were identified as having a follow-up of [ge]6 months from the date of surgery. The mean ...
Source: BJU International - November 10, 2009 Category: Urology & Nephrology Authors: Aaron D. Martin, Rafael N. Nunez, Anna Pacelli, Michael E. Woods, Rodney Davis, Raju Thomas, Paul E. Andrews, Erik P. Castle Source Type: journals

Curcumin Potentiates the Antitumor Effects of Bacillus Calmette-Guerin against Bladder Cancer through the Downregulation of NF-{kappa}B and Upregulation of TRAIL Receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although Bacillus Calmette-Guerin (BCG) intravesical therapy is a standard treatment for bladder cancer, eventual failure of response is a major problem. Treatments that can augment BCG therapy are urgently needed. We investigated whether curcumin, a component of Curcuma longa (also called turmeric), has potential to improve the current therapy using in vitro and in vivo MBT-2 murine tumor models. We found that curcumin potentiated BCG-induced apoptosis of human bladder cancer cells. BCG stimulated the release of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) from peripheral mononuclear neutrophils in ...
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Kamat AM, Tharakan ST, Sung B, Aggarwal BB Tags: cancer Res Source Type: journals

Survivin as a Prognostic Marker for Urothelial Carcinoma of the Bladder: A Multicenter External Validation Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Survivin expression improves our accuracy for prediction of cancer recurrence and survival in pT(1-3)N(0)M(0) patients by a small but statistically significant margin. Our findings support the need for further evaluation of survivin and its signaling pathways as well as survivin-targeted therapies in bladder cancer. (Clin Cancer Res 2009;15(22):7012-9). PMID: 19903782 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 10, 2009 Category: Cancer & Oncology Authors: Shariat SF, Karakiewicz PI, Godoy G, Karam JA, Ashfaq R, Fradet Y, Isbarn H, Montorsi F, Jeldres C, Bastian PJ, Nielsen ME, Müller SC, Sagalowsky AI, Lotan Y Tags: Clin cancer Res Source Type: journals

Postprostatectomy incontinenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews our current understanding of postprostatectomy incontinence with an emphasis on diagnosis and management. Content Type Journal ArticleDOI 10.1007/s11884-009-0029-8Authors Jaspreet S. Sandhu, Memorial Sloan-Kettering Cancer Center Department of Surgery/Urology 1275 York Avenue New York NY 10065 USA Journal Current Bladder Dysfunction ReportsOnline ISSN 1931-7220Print ISSN 1931-7212 Journal Volume Volume 4 Journal Issue Volume 4, Number 4 / December, 2009 (Source: Current Bladder Dysfunction Reports)
Source: Current Bladder Dysfunction Reports - November 9, 2009 Category: Urology & Nephrology Tags: Current bladder Dysfunction Reports Source Type: journals

The Christie Experience of Neoadjuvant Chemotherapy for Invasive Bladder Cancer. Tolerance, Short Term Response and Time to Definitive TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Neoadjuvant chemotherapy in muscle-invasive bladder cancer has demonstrated a 5% improvement in absolute overall survival (OS) at 5 years. This retrospective study addressed the tolerance and response to this approach. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: B. Jyoti, C. Chan, D. Corgie, A. Choudhury, J. Wylie Tags: Abstracts Source Type: journals

Long Term Follow-up of Patients Receiving High Dose Rate (HDR) Brachytherapy Boost in Combination with External Beam Radiotherapy Treatment (EBRT) for High Risk Prostate Cancer: Relapse Rate and ToxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Prostate cancer is the most commonly diagnosed male cancer in the UK; one third of all new cases present with locally advanced disease. At UCLH, high risk patients deemed to benefit from dose escalation have been treated with combined EBRT and HDR brachytherapy boost since 2000. We revisited 32 of these patients to assess late bowel and bladder toxicity, survival, biochemical relapse and metastatic disease rates. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: A. Swampillai, R. Lewis, H. Payne Tags: Abstracts Source Type: journals

The Effect on Pelvic Lymph Node Dose after Reducing the Internal Margin of the Planning Target Volume for Bladder CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a recent paper by Mangar et al. examining the interfractional changes in volume and position during bladder radiotherapy using an empty bladder protocol, it was suggested that reducing the internal margin of the planning target volume (PTV) to 1cm was feasible. An editorial by Lalondrelle and Huddart also discussed the use of smaller margins around the bladder to reduce toxicity. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: A.H. Thomson, A. Watterson, A. Liddicoat Tags: Letters Source Type: journals

EUS for Staging of Rectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 72 year-old man is found to have a rectal adenocarcinoma on screening colonoscopy. CT scan of the abdomen and pelvis is performed and shows evidence of rectal wall thickening without associated lymphadenopathy. Subsequent PET scan shows increased activity in the rectum only. Staging pull-through EUS examination is then performed. Radial imaging at 7.5 MHz shows clear identification of the bladder. Upon pull-through with the EUS scope, the rectal wall is identified showing the muscularis propria and a thickened submucosal space suggesting tumor involvement. The tumor appears to extend through the muscularis propria, shown...
Source: The Digital Atlas of Video Education - Gastroenterology - November 9, 2009 Category: Gastroenterology Authors: Jonathan M Buscaglia, MD, Instructor of Medicine, Johns Hopkins Medical Center Source Type: info

Impact of the Target Volume (Prostate Alone vs. Prostate with Seminal Vesicles) and Fraction Dose (1.8 Gy vs. 2.0 Gy) on Quality of Life Changes After External-Beam Radiotherapy for Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The risk of adverse QoL changes after EBRT for prostate cancer cannot be derived from the dose-volume histogram alone. Seminal vesicles can be included in the CTV up to a moderate total dose without adverse effects on QoL. Apart from a longer recovery period, higher fraction doses were not associated with higher toxicity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00066-009-2008-6Authors Michael Pinkawa, RWTH Aachen Department of Radiotherapy Aachen GermanyMarc D Piroth, RWTH Aachen Department of Radiotherapy Aachen GermanyKarin Fischedick, RWTH Aachen Department o...
Source: Strahlentherapie und Onkologie - November 9, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

A Dosimetric Selectivity Intercomparison of HDR Brachytherapy, IMRT and Helical Tomotherapy in Prostate Cancer RadiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HDR-BT offers better conformality in comparison with HT and IMRT and reduces the volume of healthy tissue receiving a low dose. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00066-009-2009-5Authors Johanne Hermesse, Liège University Hospital Department of Radiation Oncology Liège BelgiumSylvie Biver, Liège University Hospital Department of Radiation Oncology Liège BelgiumNicolas Jansen, Liège University Hospital Department of Radiation Oncology Liège BelgiumEric Lenaerts, Liège University Hospital Department of Medical Physics Liège BelgiumNathalie De Patoul, S...
Source: Strahlentherapie und Onkologie - November 9, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

In this issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The appropriate level of iron in a cell is critical to its health: too much and you have hereditary hemochromatosis; too little and it's iron deficiency anemia. Hepcidin-25, expressed in the liver, appears to be the principal homeostatic regulator of iron although two other forms of hepcidin are known, hepcidin-20 and hepcidin-22. Their function(s) have not been explicated, possibly they are antibacterial. Complicating matters further, up- and down-regulation of the various hepcidins are not regulated synchronously in various cell lines and primary hepatocyte cultures. To get a grip on this confusion, Hosoki et al. develop...
Source: Proteomics. Clinical Applications - November 9, 2009 Category: Biochemistry Tags: In this issue Source Type: journals

Code Status Documentation in the Outpatient Electronic Medical Records of Patients with Metastatic CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Despite the incurable nature of metastatic cancer, only a minority of patients had a code status documented in the electronic medical record. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s11606-009-1161-zAuthors Jennifer S. Temel, Massachusetts General Hospital Cancer Center 55 Fruit Street, Yawkey 7B Boston MA 02114 USAJoseph A. Greer, Massachusetts General Hospital Cancer Center 55 Fruit Street, Yawkey 7B Boston MA 02114 USASonal Admane, Massachusetts General Hospital Cancer Center 55 Fruit Street, Yawkey 7B Boston MA 02114 USAJessica Solis, Massachusetts General Hospital ...
Source: Journal of General Internal Medicine - November 6, 2009 Category: Internal Medicine Tags: Journal of General Internal Medicine Source Type: journals

[Symposium of the German Bladder Cancer Association.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One year after the official founding of the German Bladder Cancer Association the interdisciplinary association organized its first symposium on bladder cancer at the meeting center"Schloss Mickeln" in Düsseldorf in June 2009. The focus of the symposium was on the initiation and implementation of primary objectives of the association. Members from national and international research groups presented and discussed current projects. A period of 12 months has been required to establish a national tissue bank for bladder cancer speciem which will be started in January 2010. The meeting not only stirred new ideas but a...
Source: Der Urologe. Ausg. A - November 6, 2009 Category: Urology & Nephrology Authors: Retz M, Nawroth R, Olbert P, Hartmann A, Stöhr R, Merseburger AS, Schulz W Tags: Urologe A Source Type: journals

ASTRO: Bladder-Sparing Therapy a Good Alternative (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CHICAGO (MedPage Today) -- Organ-sparing multimodal therapy for invasive bladder cancer achieves survival comparable to that of radical cystectomy, but with better quality of life, according to a study reported here. (Source: MedPage Today Radiology)
Source: MedPage Today Radiology - November 5, 2009 Category: Radiology Source Type: news

Predictive Biosciences Announces Publication Of Results From A Pilot Study Of Its Non-Invasive Assay To Monitor Patients For Bladder CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Predictive Biosciences Inc. today announced the publication of pilot study results in the November issue of the Journal of Urology, highlighting the Company's novel urinary biomarker approach to bladder cancer detection that achieves exceptionally high Negative and Positive Predictive Values (NPV and PPV). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 4, 2009 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Clusterin and chemoresistance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resistance to anticancer agents is one of the primary impediments to effective cancer therapy. Chemoresistance occurs not only to clinically established therapeutic agents but also to novel targeted therapeutics. Both intrinsic and acquired mechanisms have been implicated in drug resistance but it remains controversial which mechanisms are responsible that lead to failure of therapy in cancer patients. Recent focus has turned to clusterin (CLU) as a key contributor to chemoresistance to anticancer agents. Its role has been documented in prostate cancer for paclitaxel/docetaxel resistance as well as in renal, breast, an...
Source: Advances in Cancer Research - November 4, 2009 Category: Cancer & Oncology Authors: Djeu JY, Wei S Tags: Adv cancer Res Source Type: journals

A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HT and IMRT techniques achieved comparable target dose coverage and organ sparing, whereas HT plans were more homogeneous for both men and women. PMID: 19896229 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 4, 2009 Category: Radiology Authors: Joseph KJ, Syme A, Small C, Warkentin H, Quon H, Ghosh S, Field C, Pervez N, Tankel K, Patel S, Usmani N, Severin D, Nijjar T, Fallone G, Pedersen J Tags: Radiother Oncol Source Type: journals

Beyond the Abstract - Non-invasive methods to detect schistosome-based bladder cancer: is ...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BERKELEY, CA (UroToday.com) - Urinary schistosomiasis caused by the trematode parasite Schistosoma haematobium is endemic in most of Africa. (Source: UroToday)
Source: UroToday - November 3, 2009 Category: Urology & Nephrology Tags: Browse Categories - Beyond the Abstract Source Type: info