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Endometriosis: associations with menopause, hormone replacement therapy and cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometriosis is an estrogen-dependent condition and is characterized by the presence of ectopic endometrial tissue. The pathogenesis of this condition remains an enigma. Endometriosis has well known associations with menopause both in terms of secondary outcomes from medical and surgical therapy in premenopausal women, as well as a natural occurrence/recurrence of the disease in women going through menopause naturally. This review article aims to discuss the current day modalities of management of endometriosis with their pros and cons especially in the context of menopause and cancer. (Source: Menopause International)
Source: Menopause International - November 21, 2009 Category: Primary Care Authors: Palep-Singh, M., Gupta, S. Tags: Reviews Source Type: journals

Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival.A retrospective review of 169 black women and 982 white women with the International Federation of Gynecologists and Obstetricians stage III, stage IV, or recurrent endometrial carcinoma was performed. All patients received doxorubicin combined with cisplatin. Chemotherapy parameters that were reviewed included relative dose, relative time, and relative dose intensity. Treatment cycles [ge]7 were defined as treatment completion.Although black patients ...
Source: Cancer - November 19, 2009 Category: Cancer & Oncology Authors: John H. Farley, Chunqiao Tian, G. Scott Rose, Carol L. Brown, Michael Birrer, John I. Risinger, J. Tate Thigpen, Gini F. Fleming, Holly H. Gallion, G. Larry Maxwell Source Type: journals

Cervical cytology in patients with postmenopausal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the role of cervical cytology in the diagnosis of post or perimenopausal (PM) bleeding was explored. A total of 135 patients with PM bleeding were selected. In all these cases both conventional cervical cytology and histopathology follow up were available. The commonest causes of postmenopausal (PM) bleeding with abnormal histopathology were squamous cell carcinoma of cervix (14), endocervical polyp (13), endometrial adenocarcinomas (13) and simple hyperplasia without atypia (13). There were a total 13 cases of endometrial adenocarcinoma and cervical smears of these cases were reported as high grade squamous...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Jasleen Kaur, Pranab Dey, Subhash Chandra Saha, Arvind Rajwanshi, Raje Nijhawan, Srinivasan Radhika, Nalini Gupta Source Type: journals

How to deal with prognostic factors and radiotherapy results in uterine neoplasms with a sarcomatous component?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Uterine tumours with a sarcomatous component have a poor outcome in spite of treatment in comparison to endometrial carcinoma, probably due to the higher frequency of adverse prognostic factors. In early stages tumour size was the most determining factor for OS, DFS, LRFS and DMFS. Radiotherapy significantly improved these survivals in advanced cases. Content Type Journal ArticleCategory Research ArticlesDOI 10.1007/s12094-009-0424-9Authors Ángeles Rovirosa, Hospital Clínic i Universitari Radiation Oncology Department ICMHO, IDIBAPS C/Villarroel, 170 ES-08036 Barcelona SpainCarlos Ascaso...
Source: Clinical and Translational Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion An endometrial thickness >8 mm is more likely than that of 8 mm or less to be indicated with endometrial biopsy in premenopausal uterine bleeding. Pipelle endometrial biopsy is an accurate diagnostic procedure for the detection of high-grade endometrial lesions in premenopausal women. Content Type Journal ArticleCategory General GynecologyDOI 10.1007/s00404-009-1290-yAuthors Suna Özdemir, Selçuk University Department of Gynecology and Obstetric, Meram Medical Faculty Konya TurkeyÇetin Çelik, Selçuk University Department of Gynecology and Obstetric, Meram Medical Faculty Ko...
Source: Archives of Gynecology and Obstetrics - November 18, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Scientists Release New Data On Endometrial Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current study results from the report, 'A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma,' have been published. According to a study from the United Kingdom, Platinum compounds, taxanes and anthracyclines provide the major effective drug classes in the treatment of advanced and recurrent endometrial cancer and carcinosarcoma. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Systematic Review: Comparative Effectiveness of Medications to Reduce Risk for Primary Breast Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Three medications reduce risk for primary breast cancer but increase risk for thromboembolic events (tamoxifen, raloxifene), endometrial cancer (tamoxifen), or stroke (tibolone). Primary Funding Source: Agency for Healthcare Research and Quality. PMID: 19920271 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - November 17, 2009 Category: Internal Medicine Authors: Nelson HD, Fu R, Griffin JC, Nygren P, Smith ME, Humphrey L Tags: Ann Intern Med Source Type: journals

Hysterecomy fails to offer better disease controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A modified radical hysterectomy (class II) did not improve locoregional control and survival compared with simple extrafascial abdominal hysterectomy (class I). Investigators from University of Milano-Bicocca in Monza, Italy, randomized 520 patients with stage I endometrial cancer to class I or class II surgery. They found that the median length of parametria and vagina removed were 15 mm and 5 mm respectively for class I hysterectomy vs 20 mm and 15 mm for class II hysterectomy (P > .001). Operating time and blood loss were statistically significantly higher for class II hysterectomy. Five-year disease-free survival and o...
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info

Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings show for the first time that elevated expression of p53-R175H mutant may exert gain-of-function activity to activate the EGFR/PI3K/AKT pathway and thus may contribute to the invasive phenotype in endometrial cancer. (Source: Molecular Cancer)
Source: Molecular Cancer - November 16, 2009 Category: Cancer & Oncology Authors: Peixin DongZhujie XuNan JiaDajin LiYouji Feng Source Type: journals

The endometrium--from estrogens alone to TSECs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews publications dating back more than a century describing investigations of the endometrium, including those examining the relationship between endometrial hyperplasia and carcinoma, the influence of estrogens on the endometrium, and strategies for protecting the endometrium from unopposed estrogen stimulation. Endometrial hyperplasia and carcinoma studies date from before 1900. The influence of endogenous estrogens on the endometrium became evident with observations of endometrial hyperplasia and/or carcinoma in women with estrogen-secreting tumors or polycystic ovarian disease. Later, observational stu...
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Pickar JH Tags: Climacteric Source Type: journals

Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study provides evidence that the risk of developing gynecological cancers with E/D use of several months to a few years is similar to the risks of developing gynecological cancer without HRT or use of other HRT. PMID: 19905903 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Schneider C, Jick SS, Meier CR Tags: Climacteric Source Type: journals

Patient information. Endometrial cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19908401 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - November 15, 2009 Category: Primary Care Tags: Am Fam Physician Source Type: journals

Endometrial cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometrial cancer is the leading cause of gynecologic cancer in the United States. Etiologically, endometrial carcinoma usually results from unopposed estrogen stimulation of the endometrium, although non-estrogen-related forms occur as well. The most common presentation of endometrial cancer is postmenopausal bleeding. A variety of diagnostic modalities are available to aid in the detection of the disease, each with its own strengths and limitations. These modalities include endometrial biopsy, ultrasonography, saline infusion sonography, and hysteroscopy. A definitive diagnosis requires pathologic confirmation via e...
Source: American Family Physician - November 13, 2009 Category: Primary Care Authors: Buchanan EM, Weinstein LC, Hillson C Tags: Am Fam Physician Source Type: journals

Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary mucinous adenocarcinomas of the uterine corpus are typically low grade and frequently associated with endometrial hyperplasia and/or ordinary endometrioid adenocarcinoma, but may appear as a heterogeneous group of neoplasms. A case is described of a 56-year-old postmenopausal woman who presented with mucinous vaginal discharge. Imaging demonstrated thickened myometrium due to adenomyosis. Serum CA19-9 levels were elevated to 486 U/mL. Microscopic examination of hysterectomy specimens indicated highly differentiated mucinous adenocarcinoma diffusely infiltrating the portion of adenomyosis of the corpus. In some area...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Kaoru Abiko, Tsukasa Baba, Madoka Ogawa, Yoshiki Mikami, Takashi Koyama, Masaki Mandai, Ikuo Konishi Source Type: journals

Risk Factors for Epithelial Ovarian Cancer by Histologic Subtype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous epidemiologic studies suggest that the major histologic subtypes of epithelial ovarian cancer may have different risk factor profiles; however, no known prospective study has systematically examined differences in risk by subtype. The authors used Cox proportional hazards regression, stratified by histologic subtype and time period, to examine the association between ovarian cancer risk factors and incidence of serous invasive, endometrioid, and mucinous ovarian cancers in the US Nurses' Health Study (1976-2006) and Nurses' Health Study II (1989-2005). For each exposure, they calculated P-heterogeneity using a...
Source: Am J Epidemiol - November 12, 2009 Category: Epidemiology Authors: Gates MA, Rosner BA, Hecht JL, Tworoger SS Tags: Am J Epidemiol Source Type: journals

Robot-assisted staging using three robotic arms for endometrial cancer: Comparison to laparoscopy and laparotomy at a single institutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To demonstrate the feasibility of robot-assisted staging surgery using three arms in patients with endometrial cancer.One hundred nine patients with clinical stage I endometrial cancer who underwent staging surgery at Yonsei University Health System were enrolled from May 2006 to January 2009. Patient demographics and operative outcomes were prospectively collected.Robotic surgery using three arms was performed in 28 patients, laparoscopy in 25, and laparotomy in 56. There were no differences among the three groups in terms of patient demographics. The number of harvested pelvic lymph nodes was lower in the laparoscopy gro...
Source: Journal of Surgical Oncology - November 10, 2009 Category: Cancer & Oncology Authors: Yong Wook Jung, Dae Woo Lee, Sang Wun Kim, Eun Ji Nam, Jae Hoon Kim, Jae Wook Kim, Young Tae Kim Source Type: journals

GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract GPR30 is a novel G protein-coupled estrogen receptor (ER) associated with metastases in breast cancer (BC) and poor survival in endometrial and ovarian tumors. The association of GPR30 expression with inflammatory breast cancer (IBC), an aggressive and commonly hormone-independent form of BC, has not been studied. GPR30, ER, progesterone receptor (PR), epidermal growth factor receptor (EGFR), and HER-2 expression were assessed by immunohistochemistry (and FISH for HER-2) in 88 primary IBCs. GPR30 expression was correlated with patient overall survival (OS), disease-free survival (DFS), pathologic va...
Source: Breast Cancer Research and Treatment - November 9, 2009 Category: Cancer & Oncology Tags: Breast cancer Research and Treatment Source Type: journals

Quality of Life of Patients With Endometrial Cancer Undergoing Laparoscopic International Federation of Gynecology and Obstetrics Staging Compared With Laparotomy: A Gynecologic Oncology Group Study [Gynecologic Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although the FACT-G did not show a MID between the two surgical groups, and only modest differences in return to work and BI were found between the two groups, statistically significantly better QoL across many parameters in the laparoscopy arm at 6 weeks provides modest support for the QoL advantage of using laparoscopy to stage patients with early endometrial cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Kornblith, Huang, Walker, Spirtos, Rotmensch, Cella Tags: Surgery Gynecologic cancer Source Type: journals

Is It Safe to Treat Endometrial Carcinoma Endoscopically? [EDITORIALS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Vergote, Amant, Neven Tags: Surgery EDITORIALS Source Type: journals

Research Conducted At Johns Hopkins University Has Updated Our Knowledge About Endometrial CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Uterine serous carcinomas typically have a characteristic morphology (papillary architecture, high-grade nuclei) and immunoprofile (diffuse/strong p53 expression, loss of hormone receptor expression) that distinguish them from most endometrial endometrioid carcinomas. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 6, 2009 Category: Cancer & Oncology Source Type: news

SLC37A1 Gene expression is up-regulated by epidermal growth factor in breast cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Phospholipid biosynthesis exerts an important role in the proliferation of tumor cells; however, the regulation of the proteins involved in this context still remains to be fully evaluated. SLC37A1 protein belongs to a small family of sugar-phosphate/phosphate exchangers. The sequence homology with the bacterial glycerol-3-phosphate transporter (30%) suggests that SLC37A1 might be able to catalyze an exchange of glycerol-3-phosphate against phosphate. Glycerol-3-phosphate, found in different cellular compartments, is a fundamental substrate in phospholipid biosynthesis. In the present study, we demo...
Source: Breast Cancer Research and Treatment - November 5, 2009 Category: Cancer & Oncology Tags: Breast cancer Research and Treatment Source Type: journals

Asian Oncology Summit issues consensus statements on the management of various cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Oncology Area: News The Asian Oncology summit has issued consensus statements on the management of the following conditions in the context of basic, limited, enhanced, and maximum health-care resource availability: . Management of HER2-positive breast cancer in Asia . Management of the neck after chemoradiotherapy for head and neck cancers in Asia . Management of T-cell and natural-killer-cell neoplasms in Asia . First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia . Management of hepatocellular carcinoma in Asia . Management of endometrial cance...
Source: NeLM - Oncology - November 4, 2009 Category: Cancer & Oncology Source Type: organizations

Necrosis in Biopsy Specimen Heralds Poor Prognosis for Type I Endometrial Carcinoma PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence of necrosis on endometrial biopsy is an indicator of survival of less than 3 years in patients with type I endometrial cancer. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 3, 2009 Category: Consumer Health News Tags: Pathology & Lab Medicine Source Type: news

Epigenetic Repression of microRNA-129-2 Leads to Overexpression of SOX4 Oncogene in Endometrial Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genetic amplification, mutation, and translocation are known to play a causal role in the upregulation of an oncogene in cancer cells. Here, we report an emerging role of microRNA, the epigenetic deregulation of which may also lead to this oncogenic activation. SOX4, an oncogene belonging to the SRY-related high mobility group box family, was found to be overexpressed (P < 0.005) in endometrial tumors (n = 74) compared with uninvolved controls (n = 20). This gene is computationally predicted to be the target of a microRNA, miR-129-2. When compared with the matched endometria, the expression of miR-129-2 was lost in ...
Source: Cell Research - November 3, 2009 Category: Cytology Authors: Huang YW, Liu JC, Deatherage DE, Luo J, Mutch DG, Goodfellow PJ, Miller DS, Huang TH Tags: cancer Res Source Type: journals

Randomized Biomarker Trial of Anastrozole or Low-Dose Tamoxifen or Their Combination in Subjects with Breast Intraepithelial Neoplasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The addition of a weekly tamoxifen administration did not impair anastrozole bioavailability and modulated favorably its safety profile, providing the rationale for further studies. (Clin Cancer Res 2009;15(22):7053-60). PMID: 19887477 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 3, 2009 Category: Cancer & Oncology Authors: Bonanni B, Serrano D, Gandini S, Guerrieri-Gonzaga A, Johansson H, Macis D, Cazzaniga M, Luini A, Cassano E, Oldani S, Lien EA, Pelosi G, Decensi A Tags: Clin cancer Res Source Type: journals

Ovarian cancer update: lessons from morphology, molecules, and mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian carcinomas are a heterogeneous group of neoplasms. Pathologists currently employ a morphology-based classification system to divide ovarian carcinomas into major subgroups based on degree (tumor grade) and type of differentiation (eg, serous, endometrioid, clear cell, or mucinous). Molecular studies have shown that specific genetic defects are likely to be present in certain histologic types of ovarian carcinomas and unlikely to be present in others. Within the serous and endometrioid carcinomas, the molecular defects in low-grade versus high-grade tumors also appear to be largely distinct. Recently, mouse mode...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Cho KR Tags: Arch Pathol Lab Med Source Type: journals

Robotics and Gynecologic Oncology: Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this article were to review the published scientific literature about robotics and its application to gynecologic oncology to date and to summarize findings of this advanced computerenhanced laparoscopic technique. Relevant sources were identified by a search of PUBMED from January 1950 to January 2009 using the key words Robot or Robotics and Cervical cancer, Endometrial cancer, Gynecologic oncology, and Ovarian cancer. Appropriate case reports, case series, retrospective studies, prospective trials, and review articles were selected. A total of 38 articles were identified on the subject, and 27 were inc...
Source: The Journal of Minimally Invasive Gynecology - November 1, 2009 Category: OBGYN Authors: Jennifer E. Cho, Farr R. Nezhat Tags: Review Article Source Type: journals

Coffee may lower endometrial cancer riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK (Reuters Health) - Women dread a diagnosis of endometrial cancer, but those who drink at least two cups of caffeinated coffee a day may have a lower risk for this cancer of cells lining the uterus. (Source: Reuters: Health)
Source: Reuters: Health - October 30, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

Coffee May Lower Endometrial Cancer RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women dread a diagnosis of endometrial cancer, but those who drink at least two cups of caffeinated coffee a day may have a lower risk for this cancer of cells lining the uterus. Source: Reuters Health Related MedlinePlus Topics: Caffeine, Uterine Cancer (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 30, 2009 Category: Consumer Health News Source Type: consumer

Ovarian Preservation and Staging in Reproductive-Age Endometrial Cancer Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 726DOI: 10.1097/01.ogx.0000361368.51892.57Authors: Richter, Christine E.; Qian, Biyun; Martel, Maritza; Yu, Herbert; Azodi, Masoud; Rutherford, Thomas J.; Schwartz, Peter E. (Source: Obstetrical & Gynecological Survey)
Source: Obstetrical & Gynecological Survey - October 30, 2009 Category: OBGYN Tags: Abstract HTML PDF (625 K) Source Type: journals

Phase I Active Immunotherapy With Combination of Two Chimeric, Human Epidermal Growth Factor Receptor 2, B-Cell Epitopes Fused to a Promiscuous T-Cell Epitope in Patients With Metastatic and/or Recurrent Solid Tumors [Phase I and Clinical Pharmacology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The combination vaccines were safe and effective in eliciting antibody responses in a subset of patients (62.5%) and were associated with no serious adverse events, autoimmune disease, or cardiotoxicity. There was preliminary evidence of clinical activity in several patients. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Kaumaya, Foy, Garrett, Rawale, Vicari, Thurmond, Lamb, Mani, Kane, Balint, Chalupa, Otterson, Shapiro, Fowler, Grever, Bekaii-Saab, Carson Tags: Translational Oncology, Phase I and Clinical Pharmacology, Translational Oncology, Translational Oncology Source Type: journals

Where is the future of endometrial cancer therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19861581 [PubMed - in process] (Source: Ann Oncol)
Source: Ann Oncol - October 29, 2009 Category: Cancer & Oncology Authors: McMeekin DS Tags: Ann Oncol Source Type: journals

Obesity and endometrial cancer: challenges for public health actionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women's Health , November 2009, Vol. 5, No. 6, Pages 595-597. (Source: Future Medicine: Women's Health)
Source: Future Medicine: Women's Health - October 29, 2009 Category: OBGYN Tags: article Source Type: journals

Evidence for Cancer Stem Cells in Human Endometrial CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Emerging evidence indicates that the highly regenerative human endometrium harbors rare populations of epithelial progenitor cells. In tumors of other regenerative epithelial tissues, rare cancer stem cells (CSC) have been identified that may have originated from normal epithelial stem/progenitor cells. We hypothesized that CSC are responsible for epithelial neoplasia associated with endometrial carcinoma, the most common gynecologic malignancy in women. Stem cell characteristics of single cells isolated from endometrial carcinoma tissues from women ages 62 ± 11.8 years (n = 34) were assessed. Twenty-five of 28 endo...
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Hubbard, S. A., Friel, A. M., Kumar, B., Zhang, L., Rueda, B. R., Gargett, C. E. Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

[Review] Management of endometrial cancer in Asia: consensus statement from the Asian Oncology Summit 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the available evidence for optimum management of endometrial cancer and how management strategies can be applied in Asian countries with different levels of health-care resource availability and economic development. An overview of the literature for endometrial-cancer screening, diagnosis, and management is discussed. Consensus statements are formulated on the basis of basic, limited, enhanced, and maximum health-care resource availability, using the framework provided by the Breast Health Global Initiative. (Source: The Lancet Oncology)
Source: The Lancet Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Siriwan Tangjitgamol, Benjamin O Anderson, Hui Ti See, Chawalit Lertbutsayanukul, Nakarin Sirisabya, Tarinee Manchana, Arunachalam Ilancheran, Khai Mun Lee, Siew Eng Lim, Yin-Nin Chia, Efren Domingo, Young-Tak Kim, Chyong-Huey Lai, Ahmad Zailani Hatta Moh Tags: Review Source Type: journals

Reasons for not seeking medical help for severe pelvic floor symptoms: a qualitative study in survivors of gynaecological cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions There is a need for standardised attention to adverse effects on pelvic floor function after cancer treatment. This could be realised by quantifying symptoms using questionnaires, standardised attention for such symptoms by gynaecological oncologists or oncology nurses, and timely referral to pelvic floor specialists of women with bothersome pelvic floor symptoms. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - October 29, 2009 Category: OBGYN Authors: MH Hazewinkel, MAG Sprangers, EF Taminiau-Bloem, J van der Velden, MPM Burger, J-PWR Roovers Source Type: journals

Expression of nodal signalling components in cycling human endometrium and in endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The expression of Nodal in normal and malignant endometrial cells that lack Lefty strongly supports an important role for this embryonic morphogen in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 29, 2009 Category: Endocrinology Authors: Irene PapageorgiouPeter NichollsFang WangMartin LackmannYogeshwar MakanjiLois SalamonsenDavid RobertsonCraig Harrison Source Type: journals

Common mitochondrial polymorphisms as risk factor for endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometrial carcinoma is the most commonly diagnosed gynaecological cancer in developed countries. Although the molecular genetics of this disease had been in the focus of many research laboratories for the last 20 years, but relevant prognostic and diagnostic markers are still missing. At the same time mitochondrial DNA mutations have been reported in many types of cancer during last two decades. It is therefore more than possible, that mitochondrial genotype is one of the cancer susceptibility factors. To investigate the presence of mtDNA somatic mutations and distribution of inherited polymorphisms in endometrial adenoc...
Source: International Archives of Medicine - October 28, 2009 Category: Global & Universal Authors: Anna CzarneckaAleksandra KlembaAndrzej SemczukKatarzyna PlakBarbara MarzecTomasz KrawczykBarbara KoflerPawel GolikEwa Bartnik Source Type: journals

Where is the future of endometrial cancer therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Oncology)
Source: Annals of Oncology - October 27, 2009 Category: Cancer & Oncology Authors: McMeekin, D. S. Tags: editorial Source Type: journals

A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This regimen is generally well tolerated with encouraging efficacy. (Source: Annals of Oncology)
Source: Annals of Oncology - October 27, 2009 Category: Cancer & Oncology Authors: Ang, J. E., Shah, R. N., Everard, M., Keyzor, C., Coombes, I., Jenkins, A., Thomas, K., A'Hern, R., Jones, R. L., Blake, P., Gabra, H., Hall, G., Gore, M. E., Kaye, S. B. Tags: gynecologic tumors Source Type: journals

Intraoperative evaluation of myometrial invasion and histological type and grade in endometrial cancer: diagnostic value of frozen sectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Frozen section diagnosis was clearly more effective than preoperative diagnosis involving MRI as a basis for deciding the operative technique for endometrial cancer. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1263-1Authors Naoto Furukawa, Shizuoka Cancer Center Hospital Department of Gynecology 1007 Shimonagakubo Nagaizumi-cho, Sunto-gun Shizuoka 411-8777 JapanMunetaka Takekuma, Shizuoka Cancer Center Hospital Department of Gynecology 1007 Shimonagakubo Nagaizumi-cho, Sunto-gun Shizuoka 411-8777 JapanNobutaka Takahashi, Shizuoka Cancer Center Hospital De...
Source: Archives of Gynecology and Obstetrics - October 27, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor ActionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma is the most common type of endometrial cancer, and alterations in the expression of PTEN and K-ras have been associated with this disease. To study the roles of Pten and K-ras in endometrial cancer, we generated Pten ablation and oncogenic K-ras mutation in progesterone receptor positive cells (PRcre/+Ptenf/fK-rasG12D). Double mutant mice dramatically accelerated the development of endometrial cancer compared to a single mutation of either gene. Histological analysis showed that all of the 1-month old double mutant female ...
Source: Journal of Oncology - October 27, 2009 Category: Cancer & Oncology Source Type: journals

Incident cancer burden attributable to excess body mass index in 30 European countriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Excess adiposity is associated with increased risks of developing adult malignancies. To inform public health policy and guide further research, the incident cancer burden attributable to excess body mass index (BMI [ge] 25 kg/m2) across 30 European countries were estimated. Population attributable risks (PARs) were calculated using European- and gender-specific risk estimates from a published meta-analysis and gender-specific mean BMI estimates from a World Health Organization Global Infobase. Country-specific numbers of new cancers were derived from Globocan2002. A ten-year lag-period between risk exposure and cancer inc...
Source: International Journal of Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Andrew G. Renehan, Isabelle Soerjomataram, Margaret Tyson, Matthias Egger, Marcel Zwahlen, Jan Willem Coebergh, Iain Buchan Source Type: journals

Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mammalian target of rapamycin (mTOR) is an intracellular serine/threonine protein kinase positioned at a central point in a variety of cellular signaling cascades. The established involvement of mTOR activity in the cellular processes that contribute to the development and progression of cancer has identified mTOR as a major link in tumorigenesis. Consequently, inhibitors of mTOR, including temsirolimus, everolimus, and ridaforolimus (formerly deforolimus) have been developed and assessed for their safety and efficacy in patients with cancer. Temsirolimus is an intravenously administered agent approved by the US Food a...
Source: Journal of Hematology and Oncology - October 27, 2009 Category: Hematology Authors: RuiRong YuanAndrea KayWilliam BergDavid Lebwohl Source Type: journals

Utility of liquid-based cytology in endometrial pathology: diagnosis of endometrial carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of this study revealed that applying diagnostic criteria used in CCP to LBC was easy to achieve, because LBC had excellent cytoarchitectural preservation and cells were well presented. Although we have not examined all cytological features of malignancy and have not considered atypical hyperplasia, we believe that this method may be a useful tool in the diagnosis of endometrial cytology. (Source: Cytopathology)
Source: Cytopathology - October 27, 2009 Category: Pathology Authors: Y. Norimatsu, H. Kouda, T. K. Kobayashi, K. Shimizu, K. Yanoh, C. Tsukayama, Y. Miyake, E. Ohno Source Type: journals

Precursors of endometrial and ovarian carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract This review discusses precursor lesions of endometrial and ovarian carcinoma with an emphasis on the unique molecular alterations that have led to the development of binary classification schemes for tumors of both the endometrium and ovary. While such a system is well established for endometrial carcinoma, only recently has a binary classification scheme been proposed for ovarian carcinoma. For both, the morphologic and molecular genetic-defining characteristics of their respective precursor lesions are described in detail. Furthermore, similarities and differences of the precursor lesions of speci...
Source: Virchows Archiv - October 26, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Estrogens/progesterone: Endometrial adenocarcinoma: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genetic polymorphisms of p53 and its negative regulator murine double minute 2 homolog (MDM2) have been shown to be closely associated with tumorigenesis in a variety of human cancers. In the present study, single nucleotide polymorphism (SNP) at p53 codon 72 and MDM2 promoter 309 was examined for germline DNA samples from 102 endometrial cancer cases and 95 controls using polymerase chain reaction-based fragment analysis. There were no significant differences in the genotype and allele prevalence between control subjects and endometrial cancer patients for p53 codon 72. The GG genotype frequency of MDM2-SNP309 was statist...
Source: Human Cell - October 26, 2009 Category: Cytology Authors: Osamu NUNOBIKI, Masatsugu UEDA, Michiko YAMAMOTO, Eisaku TOJI, Naomi SATO, Shinji IZUMA, Yoshiaki OKAMOTO, Kiyo TORII, Sadamu NODA Tags: Research Articles Source Type: journals

Low-dose tamoxifen in the treatment of breast ductal intraepithelial neoplasia: results of a large observational study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: High ER and especially high PgR expression is a significant adverse prognostic indicator of DIN, and low-dose tamoxifen appears to be an active treatment. Women with low-expression ER or PgR DIN do not seem to benefit from tamoxifen. A definitive clinical trial is warranted. PMID: 19858087 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Guerrieri-Gonzaga A, Botteri E, Lazzeroni M, Rotmensz N, Goldhirsch A, Varricchio C, Serrano D, Cazzaniga M, Bassi F, Luini A, Bagnardi V, Viale G, Mora S, Bollani G, Albertazzi E, Bonanni B, Decensi A Tags: Ann Oncol Source Type: journals

Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We review whether endometriosis-associated ovarian cancer is a specific entity compared with ovarian cancer not associated with endometriosis, with respect to epidemiology, natural history, and clinical diagnosis; we present a review of the English-language literature for ovarian cancer in endometriosis with respect to these three features. A recent prospective study in Japan directly showed that, during a follow-up of up to 17 years of an ovarian endometrioma cohort (n = 6398), 46 incident ovarian cancers were identified, showing that the ovarian cancer risk was significantly elevated in patients w...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals