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Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx - a follow-up study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Compared with larynx cancers salvage rates are poorer for hypopharyngeal cancers and the role of primary surgery seems to be significantly higher and more decisive in overall survival (OS). Hypopharyngeal cancers therefore warrant a closer follow-up after an organ preservation protocol, to detect recurrence at the earliest stage and plan for an effective salvage surgery. Objective: To evaluate the survival and morbidity of patients treated by surgery for carcinoma of the larynx and hypopharynx according to site. Patients and methods: All patients who had undergone laryngectomy at the Division of Surgical Oncol...
Source: Acta Oto-Laryngologica - November 21, 2009 Category: ENT & OMF Authors: Varghese BT, Sebastian P, Mathew A Tags: Acta Otolaryngol Source Type: journals

Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: Does the pattern of recurrence differ for patients with complete response and those with partial or no response?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Most esophageal cancer recurrences after neoadjuvant therapy and surgery are distant, and survival time after recurrence is short regardless of pathologic response. Fewer patients achieving complete response had recurrences, and distant recurrences in these patients manifest later than in patients showing partial response and those showing no response. Only pathologic response is significantly associated with disease recurrence, suggesting that tumor biology and chemosensitivity are critical in long-term patient outcome. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Robert A. Meguid, Craig M. Hooker, Joshua T. Taylor, Laurence R. Kleinberg, Stephen M. Cattaneo, Marc S. Sussman, Stephen C. Yang, Richard F. Heitmiller, Arlene A. Forastiere, Malcolm V. Brock Tags: General Thoracic Surgery Source Type: journals

[Notch1 expression in esophageal squamous cell carcinoma and its relation with microvascular angiogenesis.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Notch1 may be an anti-oncogene in ESCC and affects cell differentiation in early stage of the malignancy. Abnormally low expression of Notch1 in ESCC may be one of the upstream factors to induce high expression of VEGF and increased MVD. The Notch1 pathway might play a key role in microvascular angiogenesis in ESCC. PMID: 19923082 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Su CH, He YL, Chen ZG, Lei YY, Zou JY, Zhong FT, Luo HH Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

[Mechanism of photodynamic therapy against human esophageal carcinoma xenografts in nude mice.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In human esophageal carcinoma xenografts in nude mice, HpD-PDT generates singlet oxygen to result in direct tumor cell damage and cause MDA production. Caspase-3 may not be activated in the apoptotic pathway, suggesting that this pathway may not be caspase-3-dependent. PMID: 19923072 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Chen XH, Luo RC, Li LB, Ding XM, Lv CW, Zhou XP, Yan X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

Atlas of Minimally Invasive Surgery in Esophageal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
provides both an easy-to-follow procedural manual on the laparoscopic techniques for esophageal carcinoma and a comprehensive survey of the field of surgery on esophageal carcinoma.The following procedures are presented, using detailed anatomical photographs and step-by-step descriptions:Laparoscopic Trans-hiatal ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - November 19, 2009 Category: Databases & Libraries Tags: Surgery (general) Source Type: organizations

In Response to: Study to Determine Adequate Margins in Radiotherapy Planning for Esophageal Carcinoma by Detailing Patterns of Recurrence After Definitive ChemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: With interest we have read the paper by Button et al. on patterns of recurrence of esophageal cancer after primary chemoradiotherapy. Their purpose was to ascertain the adequacy of radiotherapy margins by studying the relapse patterns. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Christina T. Muijs, Jannet C. Beukema, Veronique E. Mul, Johannes A. Langendijk Tags: Letters to the Editor Source Type: journals

In Response to Dr. Muijs et al.: Adequacy of Margins in Chemoradiotherapy for Esophageal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We thank Dr. Muijs et al. for their letter and the points they raise. As stated in the paper, the gross tumor volume (GTV) was defined using information from diagnostic oesophago-gastro duodenoscopy (OGD) and computed tomographic scan, together with accurate mapping of the tumor from endoscopic ultrasound (with or without biopsy of suspicious lymph nodes). This was then extended by 2 cm in the cranio-caudal axis (following the course of the esophagus) and 1 cm in the lateral and antero-posterior directions to create the clinical target volume (CTV). The CTV was then enlarged to create the planning target vo...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Michael R. Button, Lucy Wills, Thomas D.L. Crosby Tags: Letters to the Editor Source Type: journals

Primary Amelanotic Malignant Melanoma of the EsophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A case of primary amelanotic malignant melanoma of the esophagus that presented as an esophageal mass in a 66-year-old woman is discussed. Medscape Gastroenterology (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - November 19, 2009 Category: Radiology Tags: Gastroenterology Source Type: info

Obesity and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precu...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Mini-Review Source Type: journals

Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals

Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: When cirrhotic patients with portal hypertension have HCC with PVT, a hematogenous pathway can exist for gastric metastasis of tumor thrombi involving hepatofugal flow to the stomach after TAE or EVL apart from the major pathway of direct invasion. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Ming-Luen Hu, Wei-Chen Tai, Seng-Kee Chuah, Yi-Chun Chiu, Keng-Liang Wu, Yeh-Pin Chou, Chung-Mou Kuo, Tsung-Hui Hu, King-Wah Chiu Source Type: journals

Woven polydioxanone biodegradable stents: a new treatment option for benign and malignant oesophageal stricturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present our initial experience with a new biodegradable (BD) esophageal stent in two patients, one for a therapy-resistant benign esophageal stricture, and the other as a temporary measure during curative radiotherapy for oesophageal carcinoma. Methods The BD stents need to be loaded into a conventional pull-back delivery system but are then placed in a standard fashion. Pre-dilatation should be avoided to reduce the risk of migration, however if migration occurs the stents can be left to dissolve in the stomach. The stents are radiolucent but easily identified on CT with minimal artefact and thus...
Source: European Radiology - November 18, 2009 Category: Radiology Tags: European Radiology Source Type: journals

Impact of lymph-node metastasis site in patients with thoracic esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis.The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal cancer. The patients were grouped according to whether the site of lymph-node metastasis was intra-thoracic, extra-thoracic, or both intra-thoracic and extra-thoracic. The patient characteristics, survival time, and prognostic factors were compared.The most significant difference in disease-specific survival was detected at a threshold value of...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Chikara Kunisaki, Hirochika Makino, Jun Kimura, Takashi Oshima, Shoichi Fujii, Ryo Takagawa, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama Source Type: journals

Tracheo-oesophageal party wall thickness in laryngectomised patients in India: Implications for surgical voice restorationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To document accurately the tracheo-oesophageal party wall thickness (PWT) intra-operatively in patients undergoing total laryngectomy and to correlate it with constitutional parameters like height, weight, body mass index (BMI), age, and gender. Also, to correlate PWT with the length of tract (LOT), that is prosthesis size, as measured using the standard valve length measuring device provided by the manufacturers.Twenty-eight patients of carcinoma larynx, following removal of the diseased larynx had their tracheo-oesophageal PWT measured using a special custom-designed and calibrated external (or outside) calliper and a pr...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Suhail I. Sayed, Kapila Manikantan, Shailesh Khode, Mohan Jagade, Vimal G. Kasbekar, Rajen Shah, Rajen S. Palav, Chris M. Nutting, Kevin J. Harrington, Peter Rhys-Evans, Rehan Kazi Source Type: journals

Researchers From University Of Utah Discuss Findings In Esophageal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with locally advanced esophageal cancer who require neoadjuvant therapy have significant dysphagia. To prospectively evaluate Polyflex stents to treat malignant dysphagia and to ameliorate weight loss in patients with locally advanced esophageal cancer who will undergo neoadjuvant therapy, scientists in the United States report. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Are patients with non-muscle-invasive bladder cancer a suitable population for a lung cancer screening trial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To estimate the relative risk of developing a second primary neoplasm, in particular lung cancer, after having non-muscle-invasive bladder cancer (NMIBC). Patients were included in the study if they had developed NMIBC between 1995 and 2003. All clinical data were extracted from the medical records of our institution's database. The interval between neoplasms, smoking habits, histological subtypes and survival were also analysed. Patient follow-up was [ge]5 years. We found 231 patients with NMIBC, 39 of which had a second primary neoplasm: 10 lung cancer, one pancreas, one gastric, one pharynx, one liver, one parathyroid, ...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Javier del Rey, José Placer, Felip Vallmanya, Núria Pujol, Esther Prat, Rosa Miró, Antoni Gelabert Source Type: journals

EMEA recommends orphan drug status for Elafin for cancer of the oesophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: BioSpace Area: News According to a report by BioSpace.com, the Committee for Orphan Medical Products (COMP) of the European Medicines Agency (EMEA) has issued a recommendation granting orphan drug status for Elafin for the treatment of oesophagus carcinoma. The orphan drug status will become effective upon ratification of this recommendation by the European Commission, and is expected to occur in the last quarter of 2009. Elafin has already been granted orphan drug status for the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension in 2007. (Source: NeLM - News)
Source: NeLM - News - November 17, 2009 Category: Drugs & Pharmacology Source Type: organizations

Randomized Clinical Trials in Esophageal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of esophageal cancer with curative intent remains highly controversial, with advocates of surgery alone, chemoradiotherapy alone, surgery with adjuvant therapy (including neoadjuvant and postoperative), and trimodality therapy each contributing prospective randomized controlled trials (PRCTs) to the body of scientific publications between 2000 and 2008. Any improvements in survival have been small in absolute percentage terms, and as such PRCTs published over the last decade have met the same primary obstacle encountered by the studies from the two prior decades, namely lack of power to detect small differenc...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Stephen A. Barnett, Nabil P. Rizk Source Type: journals

Turmeric may induce cell death in esophageal cancer sans apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Turmeric, or curcumin (diferuloylmethane), may be a favorable agent for the prevention and treatment of esophageal cancer, according to researchers at the Cork Cancer Research Center and Mercy University Hospital in Cork, Ireland. The authors noted that turmeric was able to induce cell death by a mechanism that is not reliant on apoptosis induction. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info

Three-dimensional conformal radiation therapy for squamous cell carcinoma of the esophagus: A prospective phase I/II study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although 3-DCRT to 66Gy for esophageal SCC was well tolerated, the local control was disappointing. The result supports the use of chemoradiation as the standard care for esophageal SCC. PMID: 19919886 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Wu KL, Chen GY, Xu ZY, Fu XL, Qian H, Jiang GL Tags: Radiother Oncol Source Type: journals

Heredity, diet and lifestyle as determining risk factors for the esophageal cancer on Nanao Island in Southern ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In this case–control study we evaluated contribution of environmental and genetic factors for risk of esophageal cancer (EC) by studying populations on Nanao Island (highest risk area for EC in China) and Shanwei (low risk region). Data on lifestyle, diet and family history were collected from the 166 newly diagnosed EC patients on Nanao between 2003 and 2004, from their 1450 first degree relatives and from controls on Nanao and Shanwei. Univariate and logistic regression analysis, family aggregation patterns, standardized incidence ratio (SIR), segregation ratio and heritability index were evalua...
Source: Familial Cancer - November 14, 2009 Category: Cancer & Oncology Tags: Familial cancer Source Type: journals

Influence of neoadjuvant radio-chemotherapy on tumor-infiltrating lymphocytes in squamous esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Neoadjuvant RCT reduced the number of TILs in esophageal SCC. This was primarily seen in the centre of tumors and suggests that the effect of RCT on immunological response is located in the centre of tumors. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: U. Zingg, M. Montani, D.M. Frey, S. Dirnhofer, P. Went, D. Oertli Tags: Original Articles Source Type: journals

High-resolution endoscopy and endoscopic ultrasound for evaluation of early neoplasia in Barrett’s esophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Submucosal invasion is detected by EUS for 26% of patients with EBN. The value of EUS staging before resection for type 0–IIb early Barrett’s cancer (flat lesions) is limited because 100% of these lesions are limited to the mucosa. For the management algorithm in this selected cohort, the use of EUS should be reconsidered. Content Type Journal ArticleDOI 10.1007/s00464-009-0737-3Authors T. Thomas, Nottingham University Hospitals NHS Trust Nottingham Digestive Diseases Centre and Biomedical Research Unit Queens Medical Centre Campus Nottingham NG7 2UH UKD. Gilbert, Western General Hospit...
Source: Surgical Endoscopy - November 14, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Data From National Institutes Of Health Advance Knowledge In Squamous Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The dismal outcome of esophageal cancer patients highlights the need for novel prognostic biomarkers, such as microRNAs (miRNA). (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 14, 2009 Category: Cancer & Oncology Source Type: news

Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the article by Takubo et al . This collaborative work between Japanese and German workers reported that more than 70% of their cases showed cardiac/fundic-type mucosa adjacent to the tumors studied and proposed it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells. (Source: Human Pathology)
Source: Human Pathology - November 13, 2009 Category: Pathology Authors: Olorunda Rotimi Tags: Correspondence Source Type: journals

Cancer of the EsophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - November 13, 2009 Category: Journals (General) Source Type: info

Toxicity report of a phase 1/2 dose-escalation study in patients with inoperable, locally advanced nonsmall cell lung cancer with helical tomotherapy and concurrent chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to evaluate the feasibility and toxicity of radiation dose escalation with concurrent chemotherapy using helical tomotherapy (HT) in patients with inoperable, locally advanced, stage III nonsmall cell lung cancer (LANSCLC) (grading determined according to the American Joint Committee on Cancer 6th edition grading system).This phase 1/2 study was designed to determine the maximum tolerated dose (MTD) of radiotherapy in patients with LANSCLC administered concurrently with docetaxel and cisplatin. Radiotherapy was delivered using HT. A dose per fraction escalation was applied starting at...
Source: Cancer - November 13, 2009 Category: Cancer & Oncology Authors: Samuel Bral, Michaël Duchateau, Harijati Versmessen, Douwe Verdries, Benedikt Engels, Mark De Ridder, Koen Tournel, Christine Collen, Hendrik Everaert, Denis Schallier, Jacques De Greve, Guy Storme Source Type: journals

Anterior Minithoracotomy: A Direct Approach to the Difficult Hilum for Upper Lobectomy, Pneumonectomy, and Sleeve LobectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The Chamberlain mini anterior thoracotomy provides direct access to the pulmonary hilum, facilitating dissection and vascular control for large and central tumors. Reduced perioperative pain and down-lung syndrome compared to lateral approaches can be achieved. Muscle function is preserved, and intrapericardial/hilar access is expeditious. This approach enhances hilar access and avoids the vascular control and hilar exposure challenges inherent with lateral thoracotomy. Content Type Journal ArticleCategory Thoracic OncologyDOI 10.1245/s10434-009-0799-4Authors Brian L. Pettiford, Universit...
Source: Annals of Surgical Oncology - November 12, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Original article Argon plasma coagulation (APC) for treatment of Barrett’s oesophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Argon plasma coagulation offers a safe, minimally invasive method, which gave complete regression of metaplasia and low grade dysplasia usually in more than 70% of patients with Barrett’s oesophagus. Our results show that combination of APC and PPIs is an effective treatment option for most patients with BE. (Source: Articles of Videosurgery and Other Miniinvasive Techniques - TERMEDIA publishing house)
Source: Articles of Videosurgery and Other Miniinvasive Techniques - TERMEDIA publishing house - November 12, 2009 Category: Surgery Source Type: journals

Clinical-Dosimetric Analysis of Measures of Dysphagia including Gastrostomy-tube Dependence among Head and Neck Cancer Patients Treated Definitively by Intensity-Modulated Radiotherapy with Concurrent ChemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our analysis suggests that adhering to the following parameters may decrease the risk of prolonged GT dependence and dysphagia: IPC V65 < 15%, IPC V60 < 40%, IPC Dmean < 55 Gy, and CPI Dmax < 60 Gy. (Source: Radiation Oncology)
Source: Radiation Oncology - November 12, 2009 Category: Cancer & Oncology Authors: Baoqing LiDan LiDerick LauD FarwellQuang LuuDavid RockeKathleen NewmanJean CourquinJames PurdyAllen Chen Source Type: journals

Abnormal fluorine-18-fluorodeoxyglucose uptake in benign esophageal leiomyomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A benign esophageal leiomyoma with abnormally increased fluorine-18-fluorodeoxyglucose uptake on positron emission tomography (PET) was resected thoracoscopically. The tumor, of which the maximum standardized uptake value of the lesion was 4.7, was well defined and 38 mm in diameter. Neither mitotic activity nor degeneration was found histologically; and immunoreactivity for CD34, CD117, MIB-1, and glucose transporter-1 was negative immunohistochemically. A diagnosis of gastrointestinal stromal tumor was ruled out by an oncogenic kinase gene mutation study. This case cautions against PET-dependent e...
Source: General Thoracic and Cardiovascular Surgery - November 11, 2009 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: journals

Curcumin induces apoptosis-independent death in esophageal cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Curcumin induces cell death in esophageal cancer cells, report researchers who note that it does so by a mechanism that is not reliant on apoptosis induction. (Source: MedWire News - Gastroenterology)
Source: MedWire News - Gastroenterology - November 11, 2009 Category: Gastroenterology Source Type: news

Black Raspberry Components Inhibit Proliferation, Induce Apoptosis, and Modulate Gene Expression in Rat Esophageal Epithelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nutrition and Cancer)
Source: Nutrition and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Stoner, Gary D.Schwartz, Steven J.Lechner, JohnWang, Li-ShuRiedl, Kenneth M.Zikri, Nancy N. Source Type: journals

Polymorphism in heme oxygenase-1 (HO-1) promoter and alcohol are related to the risk of esophageal squamous cell carcinoma on Chinese males.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the correlation between the HO-1 gene promoter polymorphism and alcohol, along with the risk of ESCC on Chinese males, was analyzed.The case-control study was performed in 143 ESCC patients and 264 cancer-free controls. All subjects were males. Allelotypic frequencies of (GT)n repeat were examed by PCR-based genotyping and DNA sequencing. The frequencies of L-allele and L-allele carriers (S/L and L/L genotypes) was significantly higher in ESCC patients than in controls (p =0.001 and 0.004), The adjusted ORs for ESCC with S/L and L/L genotypes vs S/S genotype was 2.212 (95% CI 1.297-3.775, p= 0.004). The adju...
Source: Neoplasma - November 11, 2009 Category: Cancer & Oncology Authors: Hu JL, Li ZY, Liu W, Zhang RG, Li GL, Wang T, Ren JH, Wu G Tags: Neoplasma Source Type: journals

Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gankyrin, a small and highly conserved protein which is identical to the p28 gene product, was found to be related with the malignant phenotypes in liver and esophageal carcinoma. However, the roles of gankyrin in colorectal carcinoma (CRC) are still unknown. In the present study, the gankyrin mRNA and protein expression in human CRC cell lines and clinical tissue samples were evaluated and correlated with clinicopathological features. Possible mechanisms by which gankyrin regulates the malignant phenotype of CRC cells were also investigated. The results demonstrated that gankyrin was obviously overexpressed in CRC tis...
Source: Cancer Biology and Therapy - November 11, 2009 Category: Cancer & Oncology Authors: Tang S, Yang G, Meng Y, Du R, Li X, Fan R, Zhao L, Bi Q, Jin J, Gao L, Zhang L, Li H, Fan M, Wang Y, Wu K, Liu J, Fan D Tags: cancer Biol Ther Source Type: journals

Independent histological risk factors for lymph node metastasis of superficial esophageal squamous cell carcinoma; implication of claudin-5 immunohistochemistry for expanding the indications of endoscopic resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopic resection is curative for superficial esophageal squamous cell carcinoma (ESCC) limited to the lamina propria. Endoscopic resection is not recommended for superficial ESCC invading muscularis mucosa or submucosa, however, because of the high frequency of lymph node metastasis (LNM) in such patients. Methods to more accurately predict LNM by analysis of endoscopically resected specimens are needed. Patients with superficial ESCC who underwent surgery without prior chemoradiotherapy (n= 110) were retrospectively examined to determine whether LNM correlated with immunohistochemical parameters and conventional histo...
Source: Diseases of the Esophagus - November 10, 2009 Category: Gastroenterology Authors: T. Chiba, H. Kawachi, T. Kawano, J. Kumagai, K. Kitagaki, M. Sekine, K. Uchida, M. Kobayashi, K. Sugihara, Y. Eishi Source Type: journals

Fourier transform infrared (FTIR) spectromicroscopic characterization of stem-like cell populations in human esophageal normal and adenocarcinoma cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
R. Zhao, L. Quaroni, A. G. Casson (Paper from Analyst) R. Zhao, Analyst, 2010, DOI: 10.1039/b914311d To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - November 10, 2009 Category: Chemistry Authors: R. ZhaoL. Quaroni A. G. Casson Source Type: journals

Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions shIGF-IR may have therapeutic utility in human digestive/gastrointestinal cancers, both alone and in combination with chemotherapy. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0151-6Authors Yu Wang, Sapporo Medical University First Department of Internal Medicine S-1, W-16, Chuo-ku Sapporo 060-8543 JapanYasushi Adachi, Sapporo Medical University First Department of Internal Medicine S-1, W-16, Chuo-ku Sapporo 060-8543 JapanArisa Imsumran, Sapporo Medical University First Department of Internal Medicine S-1, W-16, Chuo-ku Sapporo 060-8543 Jap...
Source: Journal of Gastroenterology - November 9, 2009 Category: Gastroenterology Tags: Journal of Gastroenterology Source Type: journals

Mortality in the Baltimore union poultry cohort: non-malignant diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Poultry workers may have excess occurrence of disease affecting several organs and systems, probably originating from widespread infection with a variety of microorganisms. The results for neurologic diseases could well represent important clues to the etiology of these diseases in humans. The small numbers of deaths involved in some cases limit interpretation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00420-009-0478-6Authors Eric S. Johnson, UNT Health Science Center Department of Epidemiology, School of Public Health Fort Worth TX USALillian C. Yau, Tulane Univers...
Source: International Archives of Occupational and Environmental Health - November 9, 2009 Category: Occupational Health Tags: International Archives of Occupational and Environmental Health Source Type: journals

Use of endoscopy in diagnosis and management of patients with dysphagia in an African settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study were to define the utility of esophagogastroduodenoscopy in the diagnosis and management of patients presenting with dysphagia and to determine the relative incidence of the various causes of dysphagia in Sudan. This is a prospective, cross-sectional, descriptive, hospital-based study carried out at the endoscopy unit of Soba University Hospital, Khartoum, Sudan. All patients complaining of dysphagia underwent upper gastrointestinal endoscopy with therapeutic intervention when necessary. A total of 114 patients were enrolled in the study, with a mean age of 47 years SD ± 19 and a male to femal...
Source: Diseases of the Esophagus - November 9, 2009 Category: Gastroenterology Authors: H. M. Y. Mudawi, A. O. A. Mahmoud, M. A. El Tahir, S. H. Suliman, S. Z. Ibrahim Source Type: journals

The high incidence of esophageal cancer in parts of China may result primarily from genetic rather than environmental factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the impact of changing environments on esophageal cancer by comparing age-standardized mortality rates of immigrant group to the rates of native population (natives who live in high cancer location and have never moved) and host populations (hosts who live in low cancer location and have never moved people). All ESCC deaths taking place during 1999[ndash]2004 among the migrant, native, and host populations were identified by retrospective population-based screening. Direct age-adjusted mortality rates were calculated by using the China population of year 2000 as standard population. From 1999[ndash]2004...
Source: Diseases of the Esophagus - November 9, 2009 Category: Gastroenterology Authors: Hexi Zhang, Zhichao Chen, Jinpeng Cheng, Xiaoling Zhu, Weiren Guo, Andong Hu, Yukai Du, Yikai Zhou, Youjie Wang Source Type: journals

Research Library: SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nature Signaling Update)
Source: Nature Signaling Update - November 6, 2009 Category: Research Source Type: info

Comparison between irradiated lung volumes with two-dimensional and three-dimensional conformal radiotherapy techniques for locally advanced lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: 3D radiotherapy allowed a better sparing of the lungs, both in cases of early and advanced tumors. 3D radiotherapy should be used in the treatment of patients with lung cancer, even in cases of large tumors. (Source: Radiologia Brasileira)
Source: Radiologia Brasileira - November 6, 2009 Category: Radiology Source Type: journals

Changing cancer incidence in Kampala, Uganda, 1991-2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Incidence rates of different cancers have been calculated for the population of Kyadondo County (Kampala, Uganda) for a 16-year period (1991-2006). This period coincides with continuing social and lifestyle changes and the peak and subsequent wane of the epidemic of HIV-AIDS. There has been an overall increase in the risk of cancer during the period in both sexes, with the incidence rates of cancers of the breast and prostate showing particularly marked increases (4.5% annually). Prostate cancer is now the most common cancer in men. The incidence of cancer of the esophagus, formerly the most common cancer in men and second...
Source: International Journal of Cancer - November 6, 2009 Category: Cancer & Oncology Authors: Donald Maxwell Parkin, Sarah Nambooze, Fred Wabwire-Mangen, Henry R. Wabinga Source Type: journals

Circulating Tumor Cells in Gastrointestinal Malignancies: Current Techniques and Clinical ImplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since their introduction more than 50 years by Engell, circulating tumor cells (CTCs) have been evaluated in cancer patients and their detection has been correlated with clinical outcome, in esophageal, gastric, and colorectal cancer. With the availability of refined technologies, the identification of CTCs from peripheral blood is emerging as a useful tool for the detection of malignancy, monitoring disease progression, and measuring response to therapy. However, increasing evidence suggests a variety of factors to be responsible for disease progression. The analysis of a single CTC marker is therefore unlikely to accurat...
Source: Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Source Type: journals

Field effect in cancer-an update.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The concept "field effect in cancer" originated in 1953 from the histopathological observations of Slaughter and colleagues [1] regarding the occurrence of multiple primary oral squamous cell carcinomas and their local recurrences. The development of modern molecular technologies has extended the field effect concept by exploring the molecular abnormalities in tissues that appear histologically normal. To date, such field effect biomarkers have been reported in several sites and organs, eg, head and neck, colon and rectum, prostate, breast, lung, esophagus, stomach, and skin. Two popular hypotheses have been proposed. ...
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: Chai H, Brown RE Tags: Ann Clin Lab Sci Source Type: journals

Surgeon at Work: Hand-Assisted Laparoscopic Construction of Gastric Conduit for Thoracic Esophageal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A method for hand-assisted laparoscopic construction of gastric conduit for thoracic esophageal cancer was developed. Since this endoscopic surgical procedure is less invasive than open surgery, it contributes to improvement of post-operative respiratory functions and reduces respiratory complications. What distinguishes our surgical procedure is that unlike methods described in previous reports, it begins with treatment of the left gastroepiploic vessels at the height of the inferior edge of the spleen, followed by dissection from the esophageal hiatus to the lesser curvature and then dissection and excision of left gastr...
Source: Diagnostic and Therapeutic Endoscopy - November 3, 2009 Category: Surgery Source Type: journals

p53 Mutation Status Predicts Pathological Response to Chemoradiotherapy in Locally Advanced Esophageal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Analysis of ESCC biopsy specimens for p53 gene mutation can identify patients who will not achieve pCR by CRT. The results should be confirmed by large cohort prospective studies. Content Type Journal ArticleCategory Thoracic OncologyDOI 10.1245/s10434-009-0786-9Authors Tomoki Makino, Osaka University Department of Gastroenterological Surgery, Graduate School of Medicine Osaka JapanMakoto Yamasaki, Osaka University Department of Gastroenterological Surgery, Graduate School of Medicine Osaka JapanHiroshi Miyata, Osaka University Department of Gastroenterological Surgery, Graduate School of Me...
Source: Annals of Surgical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of transnasal esophagoscopy was examined for detecting metachronous esophageal squamous carcinoma in patients with head and neck squamous cell carcinoma (HNSCC).In all, 398 transnasal esophagoscopies were performed in 293 previously treated patients with HNSCC between December 2007 and January 2009.Metachronous esophageal squamous carcinoma was detected in 15 (5.1%) patients. The prevalence rate was 15.9% (7/44) in patients with hypopharyngeal cancer, significantly higher than the 8.3% (2/24) with laryngeal, 7.1% (3/42) with oropharyngeal, and 1.6% (3/183) with oral cancer (p = .001). The stage distributions of eso...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Yan-Ye Su, Fu-Min Fang, Hui-Ching Chuang, Sheng-Dean Luo, Chih-Yen Chien Source Type: journals

Free jejunal graft reconstruction after resection of neck cancers: Our surgical techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Locally advanced carcinomas arising in the hypopharynx, cervical esophagus, or thyroid are traditionally treated by resection of the hypopharynx and cervical esophagus. Various methods of reconstruction aiming to achieve safety and functionality have been reported, including the myocutaneous flap and the free jejunal graft. With advances in microscopic surgery, the free jejunal transplant is now used dominantly; however, this procedure is not without major risks. In this review we examine the short- and long-term complications of this procedure. We also describe our technique of free jejunal graft r...
Source: Surgery Today - November 2, 2009 Category: Surgery Tags: Surgery Today Source Type: journals