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Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx - a follow-up study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Compared with larynx cancers salvage rates are poorer for hypopharyngeal cancers and the role of primary surgery seems to be significantly higher and more decisive in overall survival (OS). Hypopharyngeal cancers therefore warrant a closer follow-up after an organ preservation protocol, to detect recurrence at the earliest stage and plan for an effective salvage surgery. Objective: To evaluate the survival and morbidity of patients treated by surgery for carcinoma of the larynx and hypopharynx according to site. Patients and methods: All patients who had undergone laryngectomy at the Division of Surgical Oncol...
Source: Acta Oto-Laryngologica - November 21, 2009 Category: ENT & OMF Authors: Varghese BT, Sebastian P, Mathew A Tags: Acta Otolaryngol Source Type: journals

Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: High-dose IMRT for recurrent and second primary head and neck cancer in previously irradiated territory leads to approximately 20% long-term survival in a non-selected patient population. Identification of patients who would benefit most of curative IMRT is warranted. PMID: 19919885 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Duprez F, Madani I, Bonte K, Boterberg T, Vakaet L, Derie C, De Gersem W, De Neve W Tags: Radiother Oncol Source Type: journals

Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The number of levels with pathologic lymph node, the site of primary tumor and the level of tumor invasion are decisive risk factors in determining the development of DM in head and neck SCC patients. Patients with multilevel nodal involvement in neck, with laryngeal and hypopharyngeal carcinomas, and patients with primary tumor invasion into muscular, bone or cartilage have the highest risk of developing DM. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: X. Li, B. Di, Y. Shang, Y. Zhou, J. Cheng, Z. He Tags: Original Articles Source Type: journals

Paratracheal lymph node dissection does not negatively affect thyroid dysfunction in patients undergoing laryngectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this retrospective study was to evaluate the prognostic significance of paratracheal lymph node dissection including hemithyroidectomy for the development of hypo(para)thyroidism. From 1990 to 2004, 169 patients with a carcinoma of the larynx or hypopharynx who underwent paratracheal lymph node dissection were selected. Data of 137 patients (23 women, 114 men) were analyzed. Hundred patients were tested on thyroid function. Patient, tumor and treatment characteristics were noted including age, gender, site, TNM stage and details of surgery, radiotherapy and chemotherapy. Seventy percent o...
Source: European Archives of Oto-Rhino-Laryngology - November 13, 2009 Category: ENT & OMF Tags: European Archives of Oto-Rhino-Laryngology Source Type: journals

Widespread expression of prostate apoptosis response-4 in nasopharyngeal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prostate apoptosis response-4 (Par-4) augments apoptosis in various tumors, either during apoptotic insult or by ectopic overexpression. However, investigation of Par-4 expression in nasopharyngeal carcinoma (NPC) is lacking.Specimens from patients with NPC, hypopharyngeal carcinoma (HPC), or oral cavity cancer were examined for Par-4 expression using immunohistochemistry. NPC cell proliferation and apoptosis were analyzed using immunohistochemical staining for Ki67, B-cell lymphoma 2 (Bcl-2), and in situ terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick end-labeling (TUNEL) assay, respectively.P...
Source: Head and Neck - November 12, 2009 Category: ENT & OMF Authors: Jeng-Woei Lee, Wei-Ting Hsiao, Kuei-Fang Lee, Lai-Fa Sheu, Hsue-Yin Hsu, Lee-Ping Hsu, Borcherng Su, Moon-Sing Lee, Yih-Chih Hsu, Chung-Hsing Chang Source Type: journals

Five year survival data from phase III trial of radiotherapy plus cetuximab for locoregionally advanced head and neck cancer and link between cetuximab-induced rash and survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Oncology Area: News A phase III randomised trial showed that adding cetuximab to primary radiotherapy improved locoregional control (primary endpoint) and overall survival (secondary endpoint) in patients with locoregionally advanced squamous-cell carcinoma of the head and neck (LASCCHN) at 3 years (see link to NeLM report). Five year data have now been published early online in Lancet Oncology. The study involved patients with LASCCHN of the oropharynx, hypopharynx, or larynx randomised to receive either comprehensive head and neck radiotherapy alone for 6 to 7 weeks (n = 213) or radiotherapy pl...
Source: NeLM - Oncology - November 9, 2009 Category: Cancer & Oncology Source Type: organizations

Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of transnasal esophagoscopy was examined for detecting metachronous esophageal squamous carcinoma in patients with head and neck squamous cell carcinoma (HNSCC).In all, 398 transnasal esophagoscopies were performed in 293 previously treated patients with HNSCC between December 2007 and January 2009.Metachronous esophageal squamous carcinoma was detected in 15 (5.1%) patients. The prevalence rate was 15.9% (7/44) in patients with hypopharyngeal cancer, significantly higher than the 8.3% (2/24) with laryngeal, 7.1% (3/42) with oropharyngeal, and 1.6% (3/183) with oral cancer (p = .001). The stage distributions of eso...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Yan-Ye Su, Fu-Min Fang, Hui-Ching Chuang, Sheng-Dean Luo, Chih-Yen Chien Source Type: journals

Free jejunal graft reconstruction after resection of neck cancers: Our surgical techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Locally advanced carcinomas arising in the hypopharynx, cervical esophagus, or thyroid are traditionally treated by resection of the hypopharynx and cervical esophagus. Various methods of reconstruction aiming to achieve safety and functionality have been reported, including the myocutaneous flap and the free jejunal graft. With advances in microscopic surgery, the free jejunal transplant is now used dominantly; however, this procedure is not without major risks. In this review we examine the short- and long-term complications of this procedure. We also describe our technique of free jejunal graft r...
Source: Surgery Today - November 2, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Sleep apnoea in patients after treatment of head neck cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The prevalence of sleep apnoea among patients following treatment of head and neck carcinomas seems to be slightly higher than in the normal population. The possible importance of tumour treatment features, especially transient tracheostoma, needs further assessment. OBJECTIVES: The epidemiology of sleep apnoea in patients following the treatment of head and neck cancer remains unclear. This study was undertaken to assess the prevalence of sleep apnoea in head and neck cancer patients by characterizing their clinical, anatomical and tumour treatment features. PATIENTS AND METHODS: Our study examined 31 patient...
Source: Acta Oto-Laryngologica - October 31, 2009 Category: ENT & OMF Authors: Steffen A, Graefe H, Gehrking E, König IR, Wollenberg B Tags: Acta Otolaryngol Source Type: journals

Identification of epidermal growth factor receptor (EGFR) exon 20 single nucleotide polymorphism in Chinese squamous cell carcinoma of head and neck (SCCHN).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The 78th single nucleotide polymorphism (SNP) in exon 20 of epidermal growth factor receptor (EGFR) might be a predictor of the clinical course of squamous cell carcinoma of the head and neck (SCCHN), and genetic predisposition could influence the progression of SCCHN in Chinese subjects. OBJECTIVE: To analyze the clinical significance of EGFR SNP in Chinese SCCHN patients. MATERIALS AND METHODS: Direct sequencing of exons 18-21 was used to analyze somatic mutations of EGFR. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to evaluate the expression level of EGFR. The chi-square test and Kaplan...
Source: Acta Oto-Laryngologica - October 31, 2009 Category: ENT & OMF Authors: Jin T, Yu CX, Jin T, Yu CX, Lei DP, Liu DY, Xu FL, Lu YT, Pan XL Tags: Acta Otolaryngol Source Type: journals

Role of intratumoral lymphatic vessels in the lymph node dissemination of laryngopharyngeal squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development of new markers for lymphatic endothelium allowed the study of intratumoral lymphatic microcirculation, as well as its association with lymph node metastasis.In all, 120 patients with laryngopharyngeal squamous cell carcinoma (LPSCC) without previous treatment were retrospectively studied. The immunohistochemical determination of PA2.26 antigen/podoplanin was used to assess intratumoral lymphatic vessels (ILVs) in the primary tumor.Multivariate analysis revealed that lymph node metastasis was associated with tumor location (p = .001), differentiation grade (p = .02), and ILV (p = .013). Hypopharyngeal and su...
Source: Head and Neck - October 27, 2009 Category: ENT & OMF Authors: Adolfo Hinojar-Gutiérrez, María Encarnación Fernández-Contreras, Solssireé Álvarez-Carrillo, Miguel Quintanilla, Carlos Gamallo Source Type: journals

[Occupation as a risk factor for oral and pharyngeal cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The literature reviewed shows that occupational exposure to formaldehyde may be associated with an increased risk of nasopharyngeal and hypopharyngeal cancer. The results regarding other occupational exposures are not consistent, therefore additional studies with more statistical power and better design are needed to ascertain if occupation is really a relevant risk factor for these types of cancer. PMID: 19850270 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - October 20, 2009 Category: ENT & OMF Authors: Puñal-Riobóo J, Varela-Lema L, Barros-Dios JM, Juiz-Crespo MA, Ruano-Raviña A Tags: Acta Otorrinolaringol Esp Source Type: journals

The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year periodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study represents the first population-based study in Asia attempting to stratify the patients of oral and pharyngeal carcinoma by their risk of developing a second esophageal cancer. It helps identify patients at high risk and tailor the application of intense follow-up surveillance to the estimated risk in each individual case. (Source: BioMed Central)
Source: BioMed Central - October 19, 2009 Category: Journals (General) Authors: Kuan-Der LeeChang-Hsien LuPing-Tsung ChenChunghuang Hubert ChanJen-Tsun LinCih-En HuangChih-Cheng ChenMin-Chi Chen Source Type: journals

Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A simultaneous expression of COX-2 in head and neck carcinoma was presented for the first time. Besides the prognostic impact in oral carcinogenesis, this COX-2 role of biomarker for aggressive head and neck squamous cell carcinomas should be further evaluated. Additionally, treatment of hypopharyngeal carcinomas with selective COX-2 inhibitors could be beneficial when administered in combination with radiochemotherapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10006-009-0181-5Authors Martin Scheer, University of Cologne Department for Oral and Craniomaxillo and Facial ...
Source: Oral and Maxillofacial Surgery - October 11, 2009 Category: ENT & OMF Tags: Oral and Maxillofacial Surgery Source Type: journals

Significance of Retropharyngeal Lymph Node Dissection in Hypopharyngeal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We recommend RPLN dissection at the time primary of treatment of hypopharyngeal cancer, especially in cases with cancer at subsites PC/PW, as RPLN dissection is expected to improve prognosis. The primary subsites PC/PW are associated with a risk of RPLN metastasis. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Kamiyama, R., Saikawa, M., Kishimoto, S. Tags: Original Articles Source Type: journals

Application of Tc-99m-tetrofosmin as a tumor imaging agent: Comparison with Tl-201Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, early uptakes of both the agents were similar but their retention patterns were different. Tc-99m-tetrofosmin may be used for tumor imaging though more studies are required to evaluate diagnostic accuracy and the significance of delayed images. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/BF03165405Authors Ali S. Arbab, Yamanashi Medical University Department of Radiology Tamaho-cho, Nakakoma-gun 409-38 Yamanashi JapanKiyoshi Koizumi, Yamanashi Medical University Department of Radiology Tamaho-cho, Nakakoma-gun 409-38 Yamanashi JapanTakao Arai, Yamanashi Medical University Depar...
Source: Annals of Nuclear Medicine - September 30, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

HER2 expression predicts improved survival in patients with cervical node–positive head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HER2 may be associated with longer survival in node-positive patients with HNSCC. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - September 28, 2009 Category: ENT & OMF Authors: Gary M. Tse, Kwok Hung Yu, Anthony W.H. Chan, Ann D. King, George G. Chen, Ka-Tak Wong, Raymond K.Y. Tsang, Amy B.W. Chan Tags: Head and Neck Surgery Source Type: journals

Study compares hypopharynx treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Canadian study of patients treated for squamous cell carcinoma of the hypopharynx revealed that there was no difference in outcomes between radiation therapy with or without salvage surgery, and surgery with or without postoperative radiation therapy, (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 28, 2009 Category: Radiology Source Type: info

Dietary Acrylamide Intake and the Risk of Head-Neck and Thyroid Cancers: Results From the Netherlands Cohort StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acrylamide exposure has been related to an increased incidence of oral and thyroid tumors in animal studies. In 1986, 120,852 persons (aged 55–69 years) were included in the Netherlands Cohort Study. Dietary acrylamide intake was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Hazard ratios were adjusted for smoking and other confounders. After 16.3 years of follow-up, there were 101, 83, 180, and 66 cases of oral cavity, oro-hypopharynx, larynx, and thyroid cancer, respectively. Average daily dietary acrylamide intake was 21.8 µg (standard deviation,...
Source: American Journal of Epidemiology - September 21, 2009 Category: Epidemiology Authors: Schouten, L. J., Hogervorst, J. G. F., Konings, E. J. M., Goldbohm, R. A., van den Brandt, P. A. Tags: RESEARCH-ARTICLE Source Type: journals

Oropharyngoplasty With Template-Based Reconstruction of Oropharynx Defects [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Integration of oropharyngoplasty with template-based revascularized free tissue transfer produced speech results that were independent of palate defect size, and swallow function test results were similar to other published reconstructive techniques. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 21, 2009 Category: ENT & OMF Authors: Chepeha, D. B., Sacco, A. G., Erickson, V. R., Lyden, T., Haxer, M., Moyer, J., Teknos, T. N., Prince, M. E., Eisbruch, A., Bradford, C. R., Wolf, G. T. Tags: Oncology, Head & Neck cancer, Otolaryngology/ Head & Neck Surgery, cancer Reconstruction of Head & Neck, Dysphagia, Laryngology/ Speech/ Language Pathology, Neoplasms of Head & Neck, Prognosis/ Outcomes Original Article Source Type: journals

A Phase 2 Trial of Surgery With Perioperative INGN 201 (Ad5CMV-p53) Gene Therapy Followed by Chemoradiotherapy for Advanced, Resectable Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Hypopharynx, and Larynx: Report of the Southwest Oncology Group [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This trial demonstrated the feasibility of handling and delivering a very complex gene vector safely in multiple cooperative group institutions without significant incident. Intraoperative INGN 201 gene therapy is technically feasible, but it has many logistical problems when performed in a multi-institutional setting. Regulatory requirements might have hindered accrual in this multi-institutional setting. Disease control seems to be promising; however, no definitive conclusion can be made with this small sample size. Trial Registration clinicaltrials.gov Identifier: NCT00017173 (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 21, 2009 Category: ENT & OMF Authors: Yoo, G. H., Moon, J., LeBlanc, M., Lonardo, F., Urba, S., Kim, H., Hanna, E., Tsue, T., Valentino, J., Ensley, J., Wolf, G. Tags: Oncology, Head & Neck cancer, Otolaryngology/ Head & Neck Surgery, Genetics of Head & Neck Disease, Neoplasms of Head & Neck, Drug Therapy, Drug Therapy, Other, Genetics, Genetic Counseling/ Testing/ Therapy Original Article Source Type: journals

Prediction of Simultaneous Esophageal Lesions in Head and Neck Squamous Cell Carcinoma: A Multivariate Analysis [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Clinically important esophageal lesions rarely coexists with oral cavity SCC, for which the benefit of routine esophagogastroduodenoscopy is questionable. Chromoendoscopy enhances the identification of early but clinically important esophageal abnormalities if esophagoscopy is performed for SCC in the larynx, hypopharynx, and oropharynx. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 21, 2009 Category: ENT & OMF Authors: Chow, T.-L., Lee, D. T.-Y., Choi, C.-Y., Chan, T. T.-F., Lam, S.-H. Tags: Oncology, Head & Neck cancer, Dentistry/ Oral Medicine, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, Diagnosis, Gastroenterology, Gastrointestinal Diseases Original Article Source Type: journals

ORIGINAL ARTICLE: A Phase 2 Trial of Surgery With Perioperative INGN 201 (Ad5CMV-p53) Gene Therapy Followed by Chemoradiotherapy for Advanced, Resectable Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Hypopharynx, and Larynx: Report of the Southwest Oncology GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This trial demonstrated the feasibility of handling and delivering a very complex gene vector safely in multiple cooperative group institutions without significant incident. Intraoperative INGN 201 gene therapy is technically feasible, but it has many logistical problems when performed in a multi-institutional setting. Regulatory requirements might have hindered accrual in this multi-institutional setting. Disease control seems to be promising; however, no definitive conclusion can be made with this small sample size. Trial Registration clinicaltrials.gov Identifier: NCT00017173 (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 20, 2009 Category: ENT & OMF Authors: Yoo, G. H., Moon, J., LeBlanc, M., Lonardo, F., Urba, S., Kim, H., Hanna, E., Tsue, T., Valentino, J., Ensley, J., Wolf, G. Tags: Oncology, Head & Neck cancer, Otolaryngology/ Head & Neck Surgery, Genetics of Head & Neck Disease, Neoplasms of Head & Neck, Drug Therapy, Drug Therapy, Other, Genetics, Genetic Counseling/ Testing/ Therapy Original Article Source Type: journals

ORIGINAL ARTICLE: Prediction of Simultaneous Esophageal Lesions in Head and Neck Squamous Cell Carcinoma: A Multivariate AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Clinically important esophageal lesions rarely coexists with oral cavity SCC, for which the benefit of routine esophagogastroduodenoscopy is questionable. Chromoendoscopy enhances the identification of early but clinically important esophageal abnormalities if esophagoscopy is performed for SCC in the larynx, hypopharynx, and oropharynx. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 20, 2009 Category: ENT & OMF Authors: Chow, T.-L., Lee, D. T.-Y., Choi, C.-Y., Chan, T. T.-F., Lam, S.-H. Tags: Oncology, Head & Neck cancer, Dentistry/ Oral Medicine, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, Diagnosis, Gastroenterology, Gastrointestinal Diseases Original Article Source Type: journals

ORIGINAL ARTICLE: Oropharyngoplasty With Template-Based Reconstruction of Oropharynx DefectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Integration of oropharyngoplasty with template-based revascularized free tissue transfer produced speech results that were independent of palate defect size, and swallow function test results were similar to other published reconstructive techniques. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 20, 2009 Category: ENT & OMF Authors: Chepeha, D. B., Sacco, A. G., Erickson, V. R., Lyden, T., Haxer, M., Moyer, J., Teknos, T. N., Prince, M. E., Eisbruch, A., Bradford, C. R., Wolf, G. T. Tags: Oncology, Head & Neck cancer, Otolaryngology/ Head & Neck Surgery, cancer Reconstruction of Head & Neck, Dysphagia, Laryngology/ Speech/ Language Pathology, Neoplasms of Head & Neck, Prognosis/ Outcomes Original Article Source Type: journals

Reports On Pharyngeal Cancer Findings From M. Bremke And Co-Researchers Provide New InsightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
"Definitive chemoradiation is a well-established option in the treatment of locally advanced squamous cell carcinoma of the head and neck. The intention of this study was to evaluate its efficacy on cervical lymph node metastases in a prospective studs, after a standardized protocol for chemoradiation (CRT) and histopathological evaluation, respectively," investigators in Marburg, Germany report. "The data of 25 patients (10 oropharynx, 15 hypopharynx) who received planned neck dissection after definitive chemoradiation for UICC stage I-V carcinomas of the pharynx were analyzed. All patients were sonomorphologically staged...
Source: Cancercompass News: Other Cancer - September 17, 2009 Category: Cancer & Oncology Source Type: news

Larynx Preservation Clinical Trial Design: Key Issues and Recommendations—A Consensus Panel Summary: In Regard to Lefebvre et al., for the Larynx Preservation Consensus Panel (Int J Radiat Oncol Biol Phys 2009;73:1293–1303)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest the report by Lefebvre and Ang , in which they developed guidelines for the conduct of Phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and hypopharyngeal cancer. They concluded that revised trial designs are needed to advance the study of larynx preservation. We agree that functional assessments are crucial, and the new endpoint “laryngoesophageal dysfunction-free survival” will help to improve the conclusions of future studies, in which the benefit of novel treatment options can be analyzed. (Source: International Journal of Radiation On...
Source: International Journal of Radiation Oncology * Biology * Physics - September 7, 2009 Category: Radiology Authors: Hans Christiansen, Hendrik A. Wolff, Clemens F. Hess, Ralph M.W. Rödel, Wolfgang Steiner, Christoph Matthias Tags: Letters to the Editor Source Type: journals

Dietary Acrylamide Intake and the Risk of Head-Neck and Thyroid Cancers: Results From the Netherlands Cohort Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acrylamide exposure has been related to an increased incidence of oral and thyroid tumors in animal studies. In 1986, 120,852 persons (aged 55-69 years) were included in the Netherlands Cohort Study. Dietary acrylamide intake was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Hazard ratios were adjusted for smoking and other confounders. After 16.3 years of follow-up, there were 101, 83, 180, and 66 cases of oral cavity, oro-hypopharynx, larynx, and thyroid cancer, respectively. Average daily dietary acrylamide intake was 21.8 mug (standard deviation, 12.1)....
Source: Am J Epidemiol - August 30, 2009 Category: Epidemiology Authors: Schouten LJ, Hogervorst JG, Konings EJ, Goldbohm RA, van den Brandt PA Tags: Am J Epidemiol Source Type: journals

Thyroid cancer incidentally found in radical surgery for laryngeal/hypopharyngeal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It is rare to discover an unexpected simultaneous thyroid cancer confirmed postoperatively from thyroid tissue partially removed in laryngectomy. A conservative approach is suggested for such patients. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - August 28, 2009 Category: ENT & OMF Authors: Chien Shih, Cheng-Ping Wang, Pei-Jen Lou, Ya-Ling Hu, Tsung-Lin Yang, Jenq-Yuh Ko, Shiann-Yann Lee Tags: Commentary Source Type: journals

Radiotherapy or surgery for head and neck squamous cell cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study set the baseline for clinical decisions that was not previously established there is no difference in survival for patients with hypopharynx comparing primary surgery to primary radiotherapy. This information is essential for the interpretation of current treatment results, the planning of future clinical studies and the treatment of patients who are not having chemoradiotherapy. Cancer 2009. © 2009 American Cancer Society. (Source: Cancer)
Source: Cancer - August 25, 2009 Category: Cancer & Oncology Authors: Stephen F. Hall, Patti A. Groome, Jonathan Irish, Brian O'Sullivan Source Type: journals

Changes in laryngeal sensation evaluated with a new method before and after radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted in 12 patients, 8 with laryngeal cancer and 4 with hypopharyngeal cancer, who received radiotherapy alone or chemoradiotherapy at our medical centre. Measurements were performed using a 3.3-mm-diameter flexible laryngoscope with a probe port and four types of probes with 0.06-, 0.13-, 0.20-, and 0.30-mm nylon filaments attached to a wire tip. Sensation was evaluated at the tip of the epiglottis and the arytenoid region. Measurements were performed before radiotherapy, 1, 3 months, and 1 year after completion of radiotherapy. Sensation of the epiglottis and arytenoid deteriorated sign...
Source: European Archives of Oto-Rhino-Laryngology - August 24, 2009 Category: ENT & OMF Tags: European Archives of Oto-Rhino-Laryngology Source Type: journals

Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that alterations in lymphocyte distribution in regional lymph nodes rather than at the primary tumour site may be relevant for patient prognosis. Moreover, we demonstrate that in addition to cellular immunity humoral immune responses may be clinically relevant in anti-tumour immunity. (Source: BMC Cancer)
Source: BMC Cancer - August 21, 2009 Category: Cancer & Oncology Authors: Dominik PretscherLuitpold DistelGerhard GrabenbauerMichael WittlingerMaike BuettnerGerald Niedobitek Source Type: journals

Outcomes after surgery or definitive radiotherapy for hypopharyngeal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study reported in this issue of Cancer found no survival advantage for surgery compared with radiotherapy in a large population-based study of patients treated for squamous cell carcinoma of the hypopharynx. However, other endpoints besides survival are important, including locoregional control, complications, and quality of life. (Source: Cancer)
Source: Cancer - August 19, 2009 Category: Cancer & Oncology Authors: William M. Mendenhall Source Type: journals

Impact of demographics, tumor characteristics, and treatment factors on swallowing after (chemo)radiotherapy for head and neck cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This prospective study evaluated the impact of patient demographics, tumor characteristics, and radiotherapy treatment on swallowing before and after radiotherapy or chemoradiotherapy.Eighty-one patients with head and neck cancer were examined using videofluoroscopy swallowing studies (VFSS) before treatment and again at 3 and 6 months after treatment.Swallowing was best at baseline, significantly worse 3 months posttreatment, and improved by 6 months posttreatment. Worse swallowing was associated with: living in rural areas; ex-heavy alcohol consumption; hypopharyngeal tumor site; large (particularly T4) tumors; nonconfor...
Source: Head and Neck - August 17, 2009 Category: ENT & OMF Authors: Jacqui Frowen, Susan Cotton, June Corry, Alison Perry Source Type: journals

Class III {beta}-tubulin, but not ERCC1, is a strong predictive and prognostic marker in locally advanced head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TUBB3 is a predictive and prognostic marker along with well-known p53 in HNSCC patients receiving cisplatin-based induction chemotherapy. Clinical impact of ERCC1 is not evident in this setting. (Source: Annals of Oncology)
Source: Annals of Oncology - August 3, 2009 Category: Cancer & Oncology Authors: Koh, Y., Kim, T. M., Jeon, Y. K., Kwon, T.-K., Hah, J. H., Lee, S.-H., Kim, D.-W., Wu, H.-G., Rhee, C.-S., Sung, M.-W., Kim, C. W., Kim, K. H., Heo, D. S. Tags: head and neck cancer Source Type: journals

[T1-T2 NO hypopharyngeal cancers treated with surgery alone. A GETTEC study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Surgery alone gives completely satisfactory results in terms of survival and locoregional control. In case of recurrence, this makes it possible to operate on patients in nonirradiated areas with lower morbidity and mortality and better results. These results must be confirmed by a randomized trial. PMID: 19651400 [PubMed - as supplied by publisher] (Source: Annales d'Oto-laryngologie et de Chirurgie Cervico Faciale)
Source: Annales d'Oto-laryngologie et de Chirurgie Cervico Faciale - July 31, 2009 Category: ENT & OMF Authors: Foucher M, Poissonnet G, Rame JP, Toussaint B, Védrine PO, Dassonville O, de Raucourt D, Cosmidis A Tags: Ann Otolaryngol Chir Cervicofac Source Type: journals

The utility of FDG-PET for detecting multiple primary cancers in hypopharygeal cancer patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: FDG-PET is useful for estimating the MPC in HPC patients. Since 3 of 10 synchronous oesophageal cancer were missed with PET alone, a combination with EGDS should be considered to exclude synchronous oesophageal cancer. PMID: 19639163 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - July 27, 2009 Category: Radiology Authors: Kaida H, Ishibashi M, Kurata S, Uchiyama Y, Tanaka N, Abe T, Kobayashi M, Kaibara H, Uchida M, Nakashima T, Fujita H, Hayabuchi N Tags: Nuklearmedizin Source Type: journals

Use of Combination Proteomic Analysis to Demonstrate Molecular Similarity of Head and Neck Squamous Cell Carcinoma Arising From Different Subsites [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Observed differences in outcomes between HNSCCs from different subsites may not reflect differences in tumor biologic characteristics between subsites. Rather, it is possible that observed clinical heterogeneity among HNSCCs may be based on other factors, such as viral vs chemical carcinogenesis. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - July 20, 2009 Category: ENT & OMF Authors: Weinberger, P. M., Merkley, M., Lee, J. R., Adam, B.-L., Gourin, C. G., Podolsky, R. H., Haffty, B. G., Papadavid, E., Sasaki, C., Psyrri, A., Dynan, W. S. Tags: Oncology, Head & Neck cancer, Dentistry/ Oral Medicine, Otolaryngology/ Head & Neck Surgery, Genetics of Head & Neck Disease, Laryngology/ Speech/ Language Pathology, Neoplasms of Head & Neck Original Article Source Type: journals

ORIGINAL ARTICLE: Use of Combination Proteomic Analysis to Demonstrate Molecular Similarity of Head and Neck Squamous Cell Carcinoma Arising From Different SubsitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Observed differences in outcomes between HNSCCs from different subsites may not reflect differences in tumor biologic characteristics between subsites. Rather, it is possible that observed clinical heterogeneity among HNSCCs may be based on other factors, such as viral vs chemical carcinogenesis. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - July 19, 2009 Category: ENT & OMF Authors: Weinberger, P. M., Merkley, M., Lee, J. R., Adam, B.-L., Gourin, C. G., Podolsky, R. H., Haffty, B. G., Papadavid, E., Sasaki, C., Psyrri, A., Dynan, W. S. Tags: Oncology, Head & Neck cancer, Dentistry/ Oral Medicine, Otolaryngology/ Head & Neck Surgery, Genetics of Head & Neck Disease, Laryngology/ Speech/ Language Pathology, Neoplasms of Head & Neck Original Article Source Type: journals

Fine needle aspiration in the follow up of cancer of the Oropharynx and HypopharynxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Fifty patients of carcinoma of the oropharynx and Hypopharynx who had received a full dose of radiotherapy were followed up using laryngoscopic fine needle aspiration technique. The results were compared with those of surface biopsy. 21 cases (43.75%) were diagnosed to be harbouring cancer cells using the aspiration method while only 14 cases (29.16%) showed a positive surface biopsy. Content Type Journal ArticleCategory Original/ Main ArticleDOI 10.1007/BF03052478Authors M. Gulati, Gandhi Medical Collage BhopalM. Tankwal, Gandhi Medical Collage Bhopal Journal Indian Journal of Otolaryngo...
Source: Indian Journal of Otolaryngology and Head & Neck Surgery - July 13, 2009 Category: ENT & OMF Tags: Indian Journal of Otolaryngology and Head & Neck Surgery Source Type: journals

Hypopharayngeal carcinoma in a child: Case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 15 years old boy with keratinizing squamous cell carcinoma of the Hypopharynx is being presented because of its rarity. The patient presented with pain in throat and difficulty in swallowing since 15 days. Barium swallow and direct Laryngoscopy revealed a mass in Hypopharynx. Tobacco smoking since early childhood can be the aetological factor. The patient did not consent for surgery and could not afford radiotherapy. Hence, Tracheostomy and feeding gastrosomy were done. Patient died at home two months after the diagnosis. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/BF030...
Source: Indian Journal of Otolaryngology and Head & Neck Surgery - July 7, 2009 Category: ENT & OMF Tags: Indian Journal of Otolaryngology and Head & Neck Surgery Source Type: journals

Tumour infiltrating lymphocytes in squamous cell carcinoma of the oro- and hypopharynx: Prognostic impact may depend on type of treatment and stage of diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The purpose of this study was to evaluate the prognostic influence of various subtypes of tumour infiltrating lymphocytes (TIL) in head and neck cancer, in particular the potential influence of regulatory T cells (Treg) in relation to different treatment modalities was addressed.A total of 115 patients with squamous cell carcinoma of the oro- and hypopharynx were selected. A low-risk group of 62 patients with early disease was treated by primary surgery followed by external radiotherapy. A high-risk group of 53 inoperable patients with advanced disease was treated by primary radiochemotherapy. Two-hundred and fort...
Source: Oral Oncology - July 2, 2009 Category: Cancer & Oncology Authors: Luitpold V. Distel, Rainer Fickenscher, Katrin Dietel, Alexander Hung, Heiner Iro, Johannes Zenk, Emeka Nkenke, Maike Büttner, Gerald Niedobitek, Gerhard G. Grabenbauer Tags: Electronic Pages (pp. e117-e179) Source Type: journals

Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration databaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Many subsites of head and neck cancer have changing incidence. Although treatment strategies have changed, outcome has not improved significantly from 1995 to 2006. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0636-yAuthors Orlando Guntinas-Lichius, University Hospital, Friedrich Schiller University Jena Department of Otorhinolaryngology Lessingstrasse 2 07740 Jena GermanyThomas Wendt, University Hospital, Friedrich Schiller University Jena Department of Radiooncology Jena GermanyJens Buentzel, Suedharzkrankenhaus Nordhausen Department of Otorhinolaryngology Nor...
Source: Journal of Cancer Research and Clinical Oncology - July 1, 2009 Category: Cancer & Oncology Tags: Journal of cancer Research and Clinical Oncology Source Type: journals

Risk Factors for Severe Dysphagia after Concurrent Chemoradiotherapy for Head and Neck CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Larger radiation portal field was associated with severe dysphagia induced by chemoradiotherapy. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 23, 2009 Category: Cancer & Oncology Authors: Koiwai, K., Shikama, N., Sasaki, S., Shinoda, A., Kadoya, M. Tags: Original Articles Source Type: journals

The assessment of pharyngocutaneous fistula rate in patients treated primarily with definitive radiotherapy followed by salvage surgery of the larynx and hypopharynxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine whether definitive radiotherapy prior to surgery increases the rate of pharyngocutaneous fistula (PCF) following laryngectomy or hypopharyngectomy and to determine if differences in duration of time between definitive radiotherapy and surgery alters PCF rate.A retrospective review of 152 patients treated surgically for primary laryngeal or hypopharyngeal squamous cell carcinoma.Following previous definitive radiotherapy treatment 38 patients underwent salvage surgery and 114 patients underwent primary surgery with curative intent. The PCF rate was assessed in both groups.The rate of PCF was found to be signifi...
Source: The Laryngoscope - June 17, 2009 Category: ENT & OMF Authors: Richard Dirven, Brian D. Swinson, Kan Gao, Jonathan R. Clark Source Type: journals

Successful salvage endoscopic mucosal resection for residual superficial hypopharyngeal carcinoma after chemoradiotherapy, with long-term survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopy 2009; 41: 568-569DOI: 10.1055/s-0029-1214647© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Full text (Source: Endoscopy)
Source: Endoscopy - June 17, 2009 Category: Gastroenterology Tags: Letters to the editor Source Type: journals

Late esophageal toxicity after radiation therapy for head and neck cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to determine the incidence of esophageal toxicity after radiation therapy for head and neck cancer.The records of 211 patients treated by radiation therapy for head and neck cancer were reviewed to identify those with dysphagia lasting more than 90 days after therapy. Late toxicity criteria established by the Radiation Therapy Oncology Group were used to score the symptoms.The incidence of grade 3+ esophageal toxicity at 3 and 6 months was 30% and 19%, respectively. The rate of gastrotomy-tube dependence at 3 and 6 months was 20% and 11%, respectively. Hypopharyngeal and unknown primary site (p = ...
Source: Head and Neck - June 16, 2009 Category: ENT & OMF Authors: Allen M. Chen, Bao-Qing Li, Richard L. S. Jennelle, Derick H. Lau, Claus C. Yang, Jean Courquin, Srinivasan Vijayakumar, James A. Purdy Source Type: journals

Importance of comorbidity in hypopharyngeal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Comorbidity has an impact on survival in laryngeal cancer in several reports. However, the importance of comorbidity in hypopharyngeal cancer (HPC) has not been reported.A retrospective medical record review of 156 patients with HPC treated between 1995 and 2005 was performed. Comorbid illness was measured by the Adult Comorbidity Evaluation-27. A Cox proportional hazards model was used to determine the factors related to overall survival.Comorbidity was absent in 55 (35.2%) of the patients, mild in 39 (25%), moderate in 28 (17.9%), and severe in 34 (21.8%). There were statistically significant differences between the surv...
Source: Head and Neck - June 16, 2009 Category: ENT & OMF Authors: Akihiro Homma, Tomohiro Sakashita, Nobuhiko Oridate, Fumiyuki Suzuki, Seigo Suzuki, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Shigenari Taki, Satoshi Fukuda Source Type: journals

Endotherapy for severe and complete pharyngo-esophageal post-radiation stenosis using wires, balloons and pharyngo-esophageal puncture (PEP) (with videos)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We propose the term PEP in managing complete PES. We believe this approach can offer safety and efficiency with very high success rate. Content Type Journal ArticleCategory Dynamic ManuscriptDOI 10.1007/s00464-009-0535-yAuthors Shou-jiang Tang, Trinity Mother Frances Hospitals and Clinics Department of Gastroenterology, Hepatology and Endoscopy 910 E. Houston, Suite 550 75702 Tyler TX USAShailender Singh, UT Southwestern Medical Center Division of Digestive and Liver Diseases, Department of Internal Medicine Dallas TX USAJohn M. Truelson, UT Southwestern Medical Center Department of Otolar...
Source: Surgical Endoscopy - June 11, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Case of three delayed complications of radiotherapy: Bilateral vocal cord immobility, esophageal obstruction and ruptured pseudoaneurysm of carotid arteryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case of three delayed complications following irradiation for laryngeal carcinoma: bilateral vocal cord immobility, obstruction of esophagus and spontaneously ruptured pseudoaneurysm of common carotid artery. Medial fixation of bilateral vocal cords and stenosis of cervical esophagus were noted at 28 years after radiotherapy. Spontaneous rupture of a pseudoaneurysm bulging into the hypopharynx and obstruction of the esophagus occurred at 35 years after irradiation. The life-threatening hemorrhage was successfully treated by microcoil embolization of the common carotid artery. The relationship between th...
Source: Auris, Nasus, Larynx - June 3, 2009 Category: ENT & OMF Authors: Yumiko Maruyama, Kazunori Arai, Shigeru Hoshida, Kenzi Yoneda, Mitsuru Furukawa, Tomokazu Yoshizaki Tags: Case reports Source Type: journals