Gastric (Stomach) Cancer
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New gastric cancer drug approved
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A drug to treat the seventh most common cancer in Europe has been approved by the European Medicines Agency (EMEA) (Source: Pharmacy Europe)
Source: Pharmacy Europe - November 20, 2009 Category: Drugs & Pharmacology Source Type: news
Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in PakistanEmail this article to a colleague.
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Background:
Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU).
Methods:
H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out.
Results:
...
Source: BMC Gastroenterology - November 20, 2009 Category: Gastroenterology Authors: Javed YakoobShahab AbidZaigham AbbasWasim JafriZubair AhmadRashida AhmedMuhammad Islam Source Type: journals
Frequency of Helicobacter pylori vacA genotypes in Iranian patients with gastric and duodenal ulcerEmail this article to a colleague.
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This study demonstrated that vacA slml is common genotype of H. pylori in patients with peptic ulcer and the vacA allele s1 of this bacterium is associated with ulcer. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - November 19, 2009 Category: Global & Universal Authors: M.H. Salari, M.H. Shirazi, M. Ahmmadi Hadaiti, N. Abrahimi Daryani Tags: Original Articles Source Type: journals
Roles of Radiation Dose and Chemotherapy in the Etiology of Stomach Cancer as a Second MalignancyEmail this article to a colleague.
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Purpose: To evaluate the roles of radiation dose, chemotherapy, and other factors in the etiology of stomach cancer in long-term survivors of testicular cancer or Hodgkin lymphoma.Methods and Materials: We conducted a cohort study in 5,142 survivors of testicular cancer or Hodgkin lymphoma treated in the Netherlands between 1965 and 1995. In a nested case–control study, detailed information on treatment, smoking, gastrointestinal diseases, and family history was collected for 42 patients with stomach cancer and 126 matched controls. For each subject, the mean radiation dose to the stomach was estimated. Relative risks (R...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Alexandra W. van den Belt-Dusebout, Berthe M.P. Aleman, Gijs Besseling, Marie L. de Bruin, Michael Hauptmann, Mars B. van 't Veer, Ronald de Wit, Jacques G. Ribot, Evert M. Noordijk, J. Martijn Kerst, Jourik A. Gietema, Flora E. van Leeuwen Tags: stomach Source Type: journals
Hepatic Segments and Vasculature: Projecting CT Anatomy onto Angiograms [Online Only]Email this article to a colleague.
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Hepatic transarterial interventional therapies such as chemoembolization and radiation embolization are important treatment options for hepatocellular carcinoma. Understanding the anatomy of individual arterial branches and hepatic segments is critical for selecting the correct embolization technique for treatment and to avoid complications. The authors describe the morphologic characteristics of hepatic arterial branches (and their mimickers) and hepatic segments on conventional angiograms. These vessels and segments include the celiac artery, the common and proper hepatic arteries, the left and right hepatic arteries and...
Source: Radiographics recent issues - November 19, 2009 Category: Radiology Authors: Furuta, T., Maeda, E., Akai, H., Hanaoka, S., Yoshioka, N., Akahane, M., Watadani, T., Ohtomo, K. Tags: Online Only Source Type: journals
CytRx To Initiate Phase 2 Clinical Trial With INNO-206 In Patients With Advanced Gastric CancerEmail this article to a colleague.
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CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical company, today announced plans to initiate an open-label, multinational Phase 2 clinical trial with its doxorubicin prodrug INNO-206 as a second-line treatment in patients with advanced gastric (stomach) cancer. CytRx President and CEO Steven A. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: cancer / Oncology Source Type: news
CytRx To Initiate Phase 2 Clinical Trial With INNO-206 In Patients With Advanced Gastric CancerEmail this article to a colleague.
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CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical company, today announced plans to initiate an open-label, multinational Phase 2 clinical trial with its doxorubicin prodrug INNO-206 as a second-line treatment in patients with advanced gastric (stomach) cancer. CytRx President and CEO Steven A. Kriegsman said, "This planned clinical trial is a key step forward in our plans to build a commercial oncology franchise for CytRx. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 19, 2009 Category: Cancer & Oncology Tags: cancer / Oncology Source Type: news
Making the most of gastric imaging requires clear communication between oncologists and radiologistEmail this article to a colleague.
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There is a complex array of tests for imaging the abdomen, but there are really only three things that oncologists need to tell radiologists in order to get the most from these imaging studies, according to Fergus V. Coakley, MD, chief of abdominal imaging (Source: Cancer Network)
Source: Cancer Network - November 19, 2009 Category: Cancer & Oncology Source Type: info
Effects of angiopoietin-1 on attachment and metastasis of human gastric cancer cell line BGC-823.Email this article to a colleague.
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CONCLUSION: Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrin beta1 and CD44V6, by which cell adhesion and metastasis to the ECM are promoted.
PMID: 19916173 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Ou XL, Chen HJ, Sun WH, Hang C, Yang L, Guan YY, Yan F, Chen BA Tags: World J Gastroenterol Source Type: journals
Stable knockdown of heparanase expression in gastric cancer cells in vitro.Email this article to a colleague.
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CONCLUSION: Stable knockdown of heparanase can efficiently decrease the invasiveness, metastasis and angiogenesis of human gastric cancer cells. In contrast, stable knockdown of heparanase does not affect the cell proliferation.
PMID: 19916174 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Zheng LD, Jiang GS, Pu JR, Mei H, Dong JH, Hou XH, Tong QS Tags: World J Gastroenterol Source Type: journals
Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague.
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CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.
PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals
Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan.Email this article to a colleague.
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CONCLUSION: Working or exercising after meals and H pylori infection increase the risk of GCA, but higher intakes of rice, fresh vegetables and fruits reduce the risk.
PMID: 19916179 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Chen MJ, Wu DC, Lin JM, Wu MT, Sung FC Tags: World J Gastroenterol Source Type: journals
Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathwayEmail this article to a colleague.
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Conclusions: When cirrhotic patients with portal hypertension have HCC with PVT, a hematogenous pathway can exist for gastric metastasis of tumor thrombi involving hepatofugal flow to the stomach after TAE or EVL apart from the major pathway of direct invasion. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Ming-Luen Hu, Wei-Chen Tai, Seng-Kee Chuah, Yi-Chun Chiu, Keng-Liang Wu, Yeh-Pin Chou, Chung-Mou Kuo, Tsung-Hui Hu, King-Wah Chiu Source Type: journals
Risk of suicide among operated and non-operated patients hospitalised for peptic ulcersEmail this article to a colleague.
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Conclusion:
Hospitalised patients with gastric ulcer or duodenal ulcer have an increased risk of suicide regardless of surgical treatment. These patients, especially women, are at very high risk during the first year after first hospitalisation/operation. The evaluation and management of suicidal thoughts in patients in medical settings should be further considered. (Source: Journal of Epidemiology and Community Health)
Source: Journal of Epidemiology and Community Health - November 18, 2009 Category: Epidemiology Authors: Bahmanyar, S, Sparen, P, Rutz, E M., Hultman, C M Tags: Epidemiologic studies, Cohort studies, Mortality and morbidity, Suicide (psychiatry), Suicide (public health) Research reports Source Type: journals
Swine flu vaccine uptakeEmail this article to a colleague.
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Several newspapers have reported that pregnant women and other vulnerable people are refusing to have the swine flu vaccine. The Times reported that a poll of GPs found that only 46% of people who were offered the vaccine have accepted it, and one doctor estimated that only 5% of pregnant women have had it.
The news reports are based on a “snapshot” survey of 107 GPs. The survey asked how likely they were to hit the government’s target of vaccinating at least half of their patients who are under 65 and in high-risk groups this winter. GPs were also asked to estimate how many of the people who were offered the vacci...
Source: NHS News Feed - November 18, 2009 Category: Consumer Health News Tags: Swine flu Source Type: news
Functional Divergence of Helicobacter pylori Related to Early Gastric CancerEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - November 18, 2009 Category: Biochemistry Tags: article Source Type: journals
Ovarian cancerEmail this article to a colleague.
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(Source: BMJ Online First)
Source: BMJ Online First - November 18, 2009 Category: Journals (General) Authors: Hamilton, W., Menon, U. Tags: Neurogastroenterology, Clinical trials (epidemiology), Epidemiologic studies, stomach and duodenum, General practice / family medicine, Pain (neurology), Menopause (including HRT), Colon cancer, Gynecological cancer, Screening (oncology), Radiology, Disab Source Type: journals
Woven polydioxanone biodegradable stents: a new treatment option for benign and malignant oesophageal stricturesEmail this article to a colleague.
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We present our initial experience with a new biodegradable (BD) esophageal stent in two patients, one for a therapy-resistant
benign esophageal stricture, and the other as a temporary measure during curative radiotherapy for oesophageal carcinoma.
Methods The BD stents need to be loaded into a conventional pull-back delivery system but are then placed in a standard fashion. Pre-dilatation
should be avoided to reduce the risk of migration, however if migration occurs the stents can be left to dissolve in the stomach.
The stents are radiolucent but easily identified on CT with minimal artefact and thus...
Source: European Radiology - November 18, 2009 Category: Radiology Tags: European Radiology Source Type: journals
Can the 2-13C-uracil breath test be used to predict the effect of the antitumor drug S-1?Email this article to a colleague.
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Conclusion These results suggest that the anticancer effect of S-1 can be predicted by performing UrBT 3 h after the initial oral S-1
administration.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1168-5Authors
Yukimoto Ishii, Nihon University School of Medicine Department of Surgery, Nerima Hikarigaoka Hospital 2-11-1 Hikarigaoka Nerima-ku Tokyo 179-0072 JapanShigeru Suzuki, Nihon University School of Medicine Division of Genetic and Genomic Research, Medical Research Center Itabashi-ku Tokyo 173-8610 JapanYasuo Takahashi, Nihon University School of Medicine Division ...
Source: Cancer Chemotherapy and Pharmacology - November 18, 2009 Category: Cancer & Oncology Tags: cancer Chemotherapy and Pharmacology Source Type: journals
Asbestos-related cancers among 28,300 military servicemen in the Royal Norwegian NavyEmail this article to a colleague.
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This study focus on the incidence of asbestos-related cancers among 28,300 officers and enlisted servicemen in the Royal Norwegian Navy. Until 1987, asbestos aboard the vessels potentially caused exposure to 11,500 crew members.Standardized incidence ratios (SIR) were calculated for malignant mesothelioma, lung cancer, and laryngeal, pharyngeal, stomach, and colorectal cancers according to service aboard between 1950 and 1987 and in other Navy personnel.Increased risk of mesothelioma was seen among engine room crews, with SIRs of 6.23 (95% CI = 2.51-12.8) and 6.49 (95% CI = 2.11-15.1) for personnel who served less than 2 y...
Source: American Journal of Industrial Medicine - November 18, 2009 Category: Occupational Health Authors: Leif Aage Strand, Jan Ivar Martinsen, Vilhelm F. Koefoed, Jan Sommerfelt-Pettersen, Tom Kristian Grimsrud Source Type: journals
Advanced gastric cancer in the middle one-third of the stomach: Should surgenos perform total gastrectomy?Email this article to a colleague.
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To determine which optimal surgical procedure for middle-third advanced gastric cancer (AGC) based on comparative study of the long-term prognosis between total gastrectomy (TG) and distal gastrectomy (DG).Between March 1993 and December 2005, 402 patients with middle-third AGC who underwent gastric resection were enrolled in this study. We analyzed the long-term prognosis according to the length of the proximal resection margin (PRM) and the extent of gastric resection, and determined independent prognostic factors.TG was performed in 244 patients (60.7%) and DG was performed in 158 patients (39.3%). There were no signifi...
Source: Journal of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: You-Jin Jang, Man-Sik Park, Jong-Han Kim, Sung-Soo Park, Seung-Heum Park, Seung-Joo Kim, Chong-Suk Kim, Young-Jae Mok Source Type: journals
Research On Gastric Cancer Detailed By Scientists At Kumamoto UniversityEmail this article to a colleague.
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The development of stomach cancer is closely associated with chronic inflammation, and the Wnt/beta-catenin signaling pathway is activated in most cases of this cancer. High-mobility group A (HMGA) proteins are oncogenic chromatin factors that are primarily expressed not only in undifferentiated tissues but also in various tumors, scientists writing in the American Journal of Pathology report. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news
Are patients with non-muscle-invasive bladder cancer a suitable population for a lung cancer screening trial?Email this article to a colleague.
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To estimate the relative risk of developing a second primary neoplasm, in particular lung cancer, after having non-muscle-invasive bladder cancer (NMIBC). Patients were included in the study if they had developed NMIBC between 1995 and 2003. All clinical data were extracted from the medical records of our institution's database. The interval between neoplasms, smoking habits, histological subtypes and survival were also analysed. Patient follow-up was [ge]5 years. We found 231 patients with NMIBC, 39 of which had a second primary neoplasm: 10 lung cancer, one pancreas, one gastric, one pharynx, one liver, one parathyroid, ...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Javier del Rey, José Placer, Felip Vallmanya, Núria Pujol, Esther Prat, Rosa Miró, Antoni Gelabert Source Type: journals
Application of a Novel Method of Double APAAP Staining With Subsequent Quantitative Image Analysis to the Examination of Integrin Expression in Undifferentiated-type Gastric CarcinomasEmail this article to a colleague.
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In undifferentiated-type gastric carcinoma (UGC), recognition of cancer cells is not easy, which has hampered its precise phenotypic analysis. To examine alterations of the integrin phenotype during the progression of UGC, we used double alkaline phosphatase anti-alkaline phosphatase staining and computer-aided image analyses for the expression of 1, 2, 3, 5, 6, V, β1, and β4 integrin subunits and Vβ3, Vβ5, and Vβ6 integrins in cytokeratin-positive cells in the mucosal, the submucosal, and the deeper parts of 10 early and 17 advanced UGCs, their non-neoplastic counterparts, and 9 lymph node (LN) me...
Source: Journal of Histochemistry and Cytochemistry - November 16, 2009 Category: Biochemistry Authors: Yanchenko, N., Sugihara, H., Hattori, T. Tags: Articles Source Type: journals
Randomized Clinical Trials in Gastric CancerEmail this article to a colleague.
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Minimally invasive resection has emerged as a surgical technique for gastric cancer, and there has been continued investigation to determine the appropriate extent of lymphadenectomy in gastric cancer patients. There has also been significant progress in evaluating the role of chemotherapeutic regimens used in the neoadjuvant and adjuvant settings for patients with resectable disease. We also summarize a selection of RCT trials focused on the perioperative care of the gastric cancer patient. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: James J. Mezhir, Venu G. Pillarisetty, Manish A. Shah, Daniel G. Coit Source Type: journals
Randomized Clinical Trials in Hepatocellular CarcinomaEmail this article to a colleague.
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This article reviews the most pertinent randomized controlled trials with respect to surgical and adjuvant interventions that shape the current treatment algorithm for hepatocellular carcinoma. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Adam C. Yopp, William R. Jarnagin Source Type: journals
Superficially invasive transitional cell carcinoma of the bladder associated with distant cutaneous metastasesEmail this article to a colleague.
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Cutaneous metastases from transitional cell carcinoma of the bladder are rare and most often associated with a deeply invasive primary tumor. This case report describes a 69-year-old male with previously resected superficially invasive primary transitional cell carcinoma of the bladder who presented with distant cutaneous and central nervous system metastases associated with recurrent bladder cancer. In addition, this case highlights the differential diagnosis of metastatic carcinomas that display a CK7/CK20 positive immunophenotype including transitional cell carcinoma, pancreatic carcinoma, cholangiocarcinoma and rare ga...
Source: Journal of Cutaneous Pathology - November 16, 2009 Category: Pathology Authors: Brian L. Swick, Jennifer R.S. Gordon Source Type: journals
Gastric cancer drug market to grow through targeted therapiesEmail this article to a colleague.
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(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - November 15, 2009 Category: Health Management Tags: Short communication Source Type: journals
Curability risks by endoscopic submucosal dissection for early gastric cancerEmail this article to a colleague.
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Content Type Journal ArticleCategory LetterDOI 10.1007/s00464-009-0749-zAuthors
Christof Hottenrott, Chirurgische Klinik St. Elisabethenkrankenhaus Ginnheimer Straße 3 Frankfurt 60487 Germany
Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - November 14, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals
Effectiveness and safety of splenectomy for gastric carcinoma: A meta-analysis.Email this article to a colleague.
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CONCLUSION: Splenectomy did not show a beneficial effect on survival rates compared to splenic preservation. Routinely performing splenectomy should not be recommended.
PMID: 19908346 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Yang K, Chen XZ, Hu JK, Zhang B, Chen ZX, Chen JP Tags: World J Gastroenterol Source Type: journals
Integration of traditional Japanese medicine in Japan—A survey on the use of Kampo among patientsEmail this article to a colleague.
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Conclusion: Preliminary analysis shows that Kampo is often used by patients in Japan; also by patients visiting a conventional clinic. For most diseases patients suggest a combination of Kampo and conventional treatment. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: L. Hottenbacher, T. Seki, K. Watanabe, C. Witt Source Type: journals
Clinicopathological Characteristics of Remnant Gastric Cancer After a Distal GastrectomyEmail this article to a colleague.
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Conclusions An annual follow-up endoscopic examination an after initial gastrectomy may be related to improving the prognosis of patients
with RGC.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-009-1090-5Authors
Toshiyasu Ojima, Wakayama Medical University Second Department of Surgery, School of Medicine 811-1, Kimiidera Wakayama 641-8510 JapanMakoto Iwahashi, Wakayama Medical University Second Department of Surgery, School of Medicine 811-1, Kimiidera Wakayama 641-8510 JapanMikihito Nakamori, Wakayama Medical University Second Department of Surgery, School of Medicine 811-1, ...
Source: Journal of Gastrointestinal Surgery - November 13, 2009 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals
Cluster of Cases of Salmonella enterica Serotype Rissen Infection in a General Hospital, Italy, 2007Email this article to a colleague.
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In 2007, three strains of Salmonella enterica serotype Rissen (S. Rissen) were isolated in the laboratory of diagnostic microbiology of the General Hospital of Prato, Tuscany, Italy, over a 1 month and half interval of time. The first isolate was recovered on January 26 from an outpatient with enteritis. Then, two strains were isolated on February 16 and March 11 respectively, from central venous catheters of patients who were being hospitalized in two departments of the Hospital. An epidemiologically linked cluster of cases of salmonellosis was suspected. The three strains were submitted to single enzyme-amplified fragmen...
Source: Zoonoses and Public Health - November 13, 2009 Category: Infectious Diseases Authors: T. Boschi, D. Aquilini, R. Degl'Innocenti, A. Aleo, C. Romani, P. Nicoletti, M. I. Buonomini, P. Marconi, S. Bilei, C. Mammina, A. Nastasi Source Type: journals
Multicentre study of the safety of laparoscopic subtotal gastrectomy for gastric cancer in the elderlyEmail this article to a colleague.
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The aim of this study was to assess the safety and short-term value of laparoscopic gastrectomy in the elderly with gastric cancer compared with a younger cohort.Data on all patients with gastric cancer undergoing laparoscopic gastrectomy at ten institutions in Korea between May 1998 and December 2005 were collected. Patients under the age of 45 years and those undergoing total gastrectomy, proximal gastrectomy and pylorus-preserving gastrectomy were excluded. An analysis of clinicopathological data for patients aged 45-69 years (average-age group) and those aged 70 years or more (elderly group) was undertaken.Co-morbidity...
Source: British Journal of Surgery - November 13, 2009 Category: Surgery Authors: G. S. Cho, W. Kim, H. H. Kim, S. W. Ryu, M. C. Kim, S. Y. Ryu Tags: Original Articles Source Type: journals
High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancerEmail this article to a colleague.
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Tumour vascular endothelial growth factor (VEGF) and tumour urokinase-type plasminogen activator (uPA) are prognostic factors in gastric cancer but surgical specimens are required for testing. The prognostic value of preoperative serum VEGF (s-VEGF) and serum uPA (s-uPA) levels was evaluated in patients undergoing potentially curative (R0) gastric cancer resection.Concentrations of s-VEGF and s-uPA were measured 97 patients with gastric cancer and 20 controls. Angiogenesis was measured in vitro based on human endothelial cell tube formation.Levels of s-VEGF were higher in patients with gastric cancer than controls (median ...
Source: British Journal of Surgery - November 13, 2009 Category: Surgery Authors: Ó. Vidal, J.-P. Metges, I. Elizalde, M. Valentíni, A. Volant, R. Molina, A. Castells, M. Pera Tags: Original Articles Source Type: journals
Human ribosomal protein S13 promotes gastric cancer growth through downregulating p27(Kip1).Email this article to a colleague.
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Abstract Our previous works revealed that human ribosomal protein S13 (RPS13) was upregulated in multidrug-resistant gastric cancer cells and overexpression of RPS13 could protect gastric cancer cells from drug-induced apoptosis. The present study was designed to explore the role of RPS13 in tumorigenesis and development of gastric cancer. The expression of RPS13 in gastric cancer tissues and normal gastric mucosa was evaluated by immunohistochemical staining and Western blot analysis. It was found RPS13 was expressed at a higher level in gastric cancer tissues than that in normal gastric mucosa. RPS13 was then genetic...
Source: J Cell Mol Med - November 13, 2009 Category: Molecular Biology Authors: Guo X, Shi Y, Gou Y, Li J, Han S, Zhang Y, Huo J, Ning X, Sun L, Chen Y, Sun S, Fan D Tags: J Cell Mol Med Source Type: journals
Multicentre study of the safety of laparoscopic subtotal gastrectomy for gastric cancer in the elderly.Email this article to a colleague.
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CONCLUSION:: Although elderly patients had greater co-morbidity, laparoscopic gastrectomy was a safe treatment for gastric cancer in this age group. Copyright (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
PMID: 19918857 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - November 13, 2009 Category: Surgery Authors: Cho GS, Kim W, Kim HH, Ryu SW, Kim MC, Ryu SY Tags: Br J Surg Source Type: journals
High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancer.Email this article to a colleague.
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CONCLUSION:: High preoperative s-VEGF level is an independent prognostic factor for recurrence and survival after R0 resection of gastric cancer. This may provide a useful guide to decision making regarding neoadjuvant and adjuvant therapies. Copyright (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
PMID: 19918848 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - November 13, 2009 Category: Surgery Authors: Vidal O, Metges JP, Elizalde I, Valentíni M, Volant A, Molina R, Castells A, Pera M Tags: Br J Surg Source Type: journals
Study on the Different Expression of Molecular Markers between Cardiac Cancer and Distal Gastric Cancer and Their Correlations with Clinicopathological FeaturesEmail this article to a colleague.
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Dig Surg 2009;26:384-391 (DOI:10.1159/000226766) (Source: Digestive Surgery)
Source: Digestive Surgery - November 12, 2009 Category: Surgery Source Type: journals
Early Gastric Cancer: Clinical Characteristics and Results of SurgeryEmail this article to a colleague.
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Dig Surg 2009;26:378-383 (DOI:10.1159/000226765) (Source: Digestive Surgery)
Source: Digestive Surgery - November 12, 2009 Category: Surgery Source Type: journals
Interleukin-1beta and tumor necrosis factor-alpha regulation of CDX2 homeobox gene through nuclear factor kappa B-dependent pathway in the intestinal-type gastric cancerEmail this article to a colleague.
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Abstract The aims of this study were to reveal the correlation between the transcription factor CDX2 and proinflammatory cytokines
interleukin-1beta, tumor necrosis factor-alpha in the gastric cancerous tissues and gastric cancer cell line. Expression of
CDX2 and proinflammatory cytokines in the gastric cancer tissues was analyzed by immunohistochemistry, immunoblotting and
ELISA. The effect of interleukin-1beta and tumor necrosis factor-alpha on CDX2 messenger RNA, protein and promoter activity
was analyzed in gastric cancer cell line AGS using real-time PCR, immunoblotting and EMSA. In the gastric cancerou...
Source: Medical Oncology - November 12, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals
Re-organisation of oesophago-gastric cancer care in England: progress and remaining challengesEmail this article to a colleague.
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Conclusion:
There has been considerable progress in reforming oesophago-gastric cancer services but the process of reorganisation is still incomplete and regional differences in service provision exist that may lead to variation in patient outcomes. (Source: BMC Health Services Research)
Source: BMC Health Services Research - November 12, 2009 Category: Journals (General) Authors: Tom PalserDavid CromwellRichard HardwickStuart RileyKimberley GreenawayWilliam AllumJan van der Meulen Source Type: journals
Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpusEmail this article to a colleague.
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Primary mucinous adenocarcinomas of the uterine corpus are typically low grade and frequently associated with endometrial hyperplasia and/or ordinary endometrioid adenocarcinoma, but may appear as a heterogeneous group of neoplasms. A case is described of a 56-year-old postmenopausal woman who presented with mucinous vaginal discharge. Imaging demonstrated thickened myometrium due to adenomyosis. Serum CA19-9 levels were elevated to 486 U/mL. Microscopic examination of hysterectomy specimens indicated highly differentiated mucinous adenocarcinoma diffusely infiltrating the portion of adenomyosis of the corpus. In some area...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Kaoru Abiko, Tsukasa Baba, Madoka Ogawa, Yoshiki Mikami, Takashi Koyama, Masaki Mandai, Ikuo Konishi Source Type: journals
Up regulation of GW112 Gene by NF[kappa]B promotes an antiapoptotic property in gastric cancer cellsEmail this article to a colleague.
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To clarify the regulatory mechanism of GW112 gene expression, 5[prime]-flanking region of the human GW112 gene was isolated and characterized in the present study. 5[prime]-RACE analysis showed a single transcription start site, which is located 142 nucleotides upstream of the translation initiation site. Transient transfection studies with serial deletion constructs and close examination of the sequences identified a putative NF[kappa]B binding sequence between -442 and -430, which could be responsible for efficient expression of the GW112 gene. Indeed, GW112 gene was found to be regulated by NF[kappa]B signals including ...
Source: Molecular Carcinogenesis - November 12, 2009 Category: Molecular Biology Authors: Kee K. Kim, Key S. Park, Seok B. Song, Kyoon E. Kim Source Type: journals
Radiosurgery for brain metastasis from advanced gastric cancerEmail this article to a colleague.
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Conclusions Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed
in conjunction with WBRT.
Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0554-4Authors
Jung Ho Han, Seoul National University Bundang Hospital Department of Neurosurgery 166 Gumi-ro, Bundang-gu, Seongnam-si Gyeonggi-do 463-707 KoreaDong Gyu Kim, Seoul National University College of Medicine Department of Neurosurgery 28 Yeongeon-dong, Jongno-gu Seoul 110-744 KoreaHyun-Tai Chung, Seoul National University College of Medicine Department of ...
Source: Acta Neurochirurgica - November 11, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals
Nutrition and Gastric Cancer in TurkeyEmail this article to a colleague.
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(Source: Nutrition and Cancer)
Source: Nutrition and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Yalçin, Şuayib Source Type: journals
Comparative study of the immunohistochemical expression of metalloproteinases 2, 7and 9between clearly invasive carcinomas and "in situ" trophoblast invasion.Email this article to a colleague.
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In conclusion, although there seems to be adirect link between cancer invasion and MMP9 immunohistochemical expression, the role of MMP2 and MMP7 appears to be more complicated underlining the complexity of the mechanisms involved in cancer spreading. Keywords:
PMID: 19895168 [PubMed - in process] (Source: Neoplasma)
Source: Neoplasma - November 11, 2009 Category: Cancer & Oncology Authors: Ioannidis I, Dimo B, Karameris A, Vilaras G, Gakiopoulou H, Patsouris E, Lazaris AC Tags: Neoplasma Source Type: journals
Short-term Outcomes of Roux-en-Y Stapled Anastomosis after Distal Gastrectomy for Gastric AdenocarcinomaEmail this article to a colleague.
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Conclusion There were no significant disadvantages of employing mechanical stapling for anastomosis, except for the high rate of delayed
gastric emptying. More consideration therefore needs to be given to decreasing the frequency of gastric emptying disturbance
post surgery using mechanical staples.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-009-1082-5Authors
Takeshi Fujita, National Cancer Center Hospital Gastric Surgery Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanHitoshi Katai, National Cancer Center Hospital Gastric Surgery Division 5-1-1 Tsukiji, Chuo-ku Tokyo ...
Source: Journal of Gastrointestinal Surgery - November 11, 2009 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals
Recurrence After Curative Resection of Early Gastric CancerEmail this article to a colleague.
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Conclusions Age, tumor size, number of tumors, N category, and N2 station metastasis were predictive factors for recurrence, with lymph
node metastasis being the most significant factor. After curative gastrectomy, follow-up programs should be applied for more
than 5 years for EGC patients, and computed tomography could be an essential diagnostic tool.
Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0772-2Authors
Ho Geun Youn, Seoul Veterans Hospital Department of Surgery Seoul KoreaJi Yeong An, Yonsei University College of Medicine Department of Surgery Seoul...
Source: Annals of Surgical Oncology - November 11, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals
Health Disparities in the Latino PopulationEmail this article to a colleague.
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In this review, the authors provide an approach to the study of health disparities in the US Latino population and evaluate the evidence, using mortality rates for discrete medical conditions and the total US population as a standard for comparison. They examine the demographic structure of the Latino population and how nativity, age, income, and education are related to observed patterns of health and mortality. A key issue discussed is how to interpret the superior mortality indices of Latino immigrants and the subsequent declining health status of later generations. Explanations for differences in mortality include sele...
Source: Epidemiologic Reviews - November 10, 2009 Category: Epidemiology Authors: Vega, W. A., Rodriguez, M. A., Gruskin, E. Tags: ARTICLES Source Type: journals
