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This page shows you the latest news and research items in this category.

Tumour lysis syndrome and acute kidney injury in high‐risk haematology patients in the rasburicase era. A prospective multicentre study from the Groupe de Recherche en Réanimation Respiratoire et Onco‐Hématologique
In this study, TLS occurred in 30.7% of high‐risk patients. One third of all patients experienced AKI, for which TLS was an independent risk factor. TLS was associated with increased mortality, indicating a need for interventional studies aimed at decreasing early TLS‐related deaths in this setting. (Source: British Journal of Haematology)
Source: British Journal of Haematology - June 15, 2013 Category: Hematology Authors: Michael Darmon, François Vincent, Laurent Camous, Emmanuel Canet, Caroline Bonmati, Thorsten Braun, Denis Caillot, Jérôme Cornillon, Sophie Dimicoli, Anne Etienne, Lionel Galicier, Alice Garnier, Stéphane Girault, Mathilde Hunault‐Berger, Jean‐Pie Tags: Research Paper Source Type: research

Trends in survival of patients with Burkitt lymphoma/leukemia in the USA: an analysis of 3691 cases
It is unknown whether the high rates of cure reported for Burkitt lymphoma/leukemia (BL) patients treated with chemoimmunotherapy can be verified outside published series and clinical trials. We used the Surveillance Epidemiology and End Results (SEER) database to describe time trends in outcomes of BL in the United States. Cases were divided into 2 eras based on year of diagnosis, reflecting improvements in HIV management, BL treatment, and supportive care. There was a marked improvement in survival among BL cases diagnosed in the 2002-2008 era (n = 1922) relative to 1973-2001 (n = 1769) with 5-year relative survival esti...
Source: Blood - June 13, 2013 Category: Hematology Authors: Costa, L. J., Xavier, A. C., Wahlquist, A. E., Hill, E. G. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

Burkitt's Lymphoma of the breast metastatic to the ovary diagnosed during pregnancy
A 30‐year‐old woman at 16 weeks of gestation was referred to our Institution because of rapid and progressive, bilateral enlargement of her breasts. Transvaginal sonography showed bilateral ovoidal solid ovarian masses with homogeneous hypoechoic echostructure, regular margins and very rich vascularization. Breast and ovarian biopsies were indicative of Burkitt's lymphoma (BL). Chemotherapy was initiated, and at gestational age of 22 weeks spontaneous delivery ensued. At 31 months from diagnosis, the patient remains disease free. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - June 10, 2013 Category: Radiology Authors: A.C. Testa, I. De Blasis, A. Di Legge, P. Belli, S. Hohaus, G. Ferrandina Tags: Letter to the Editor Source Type: research

High cure rates in Burkitt lymphoma and leukemia: NILG study of the German short intensive rituximab-chemotherapy program.
Abstract We evaluate the long-term results of a prospective clinical study enrolling more than 100 adult patients with Burkitt lymphoma/leukemia. Depending on extent of disease, treatment consisted of six-eight rituximab infusions and four-six intensive chemotherapy courses (attenuated in patients aged >55 years) with high-dose methotrexate, fractionated ifosfamide/cyclophosphamide, other drugs in rotation, and intrathecal chemoprophylaxis. One-hundred five patients were treated (median age 47 years, range 17-78 years); 48% had Burkitt leukemia, 25% were older than 60 years, 37% exhibited an Eastern Cooperative ...
Source: Haematologica - June 10, 2013 Category: Hematology Authors: Intermesoli T, Rambaldi A, Rossi G, Delaini F, Romani C, Pogliani EM, Pagani C, Angelucci E, Terruzzi E, Levis A, Cassibba V, Mattei D, Gianfaldoni G, Scattolin AM, Di Bona E, Oldani E, Parolini M, Gökbuget N, Bassan R Tags: Haematologica Source Type: research

Burkitt's Lymphoma of the breast metastatic to the ovary diagnosed during pregnancy.
Abstract A 30-year-old woman at 16 weeks of gestation was referred to our Institution because of rapid and progressive, bilateral enlargement of her breasts. Transvaginal sonography showed bilateral ovoidal solid ovarian masses with homogeneous hypoechoic echostructure, regular margins and very rich vascularization. Breast and ovarian biopsies were indicative of Burkitt's lymphoma (BL). Chemotherapy was initiated, and at gestational age of 22 weeks spontaneous delivery ensued. At 31 months from diagnosis, the patient remains disease free. PMID: 23754806 [PubMed - as supplied by publisher] (Source: The Ult...
Source: The Ultrasound Review of Obstetrics and Gynecology - June 10, 2013 Category: Radiology Authors: Testa AC, De Blasis I, Di Legge A, Belli P, Hohaus S, Ferrandina G Tags: Ultrasound Obstet Gynecol Source Type: research

Piperlongumine Inhibits LMP1/MYC-dependent Mouse B-Lymphoma Cells.
Abstract Piperlongumine (PL), isolated from the fruit of Long pepper, Piper longum, is a cancer-inhibiting compound that selectively kills tumor cells while sparing their normal counterparts. Here we evaluated the efficacy with which PL suppresses malignant B cells derived from a newly developed, double-transgenic mouse model of human endemic Burkitt lymphoma (BL), designated mCD40-LMP1/iMyc(Eμ). PL inhibited tumor cell proliferation in a concentration-dependent manner and induced apoptosis of neoplastic but not normal B cells. Treatment with PL resulted in downregulation of EBV-encoded LMP1, cellular Myc, constit...
Source: Biochemical and Biophysical Research communications - June 10, 2013 Category: Biochemistry Authors: Han SS, Tompkins VS, Son DJ, Kamberos NL, Stunz LL, Halwani A, Bishop GA, Janz S Tags: Biochem Biophys Res Commun Source Type: research

Constitutional mismatch repair deficiency presenting in childhood as three simultaneous malignancies
Abstract A 13‐year‐old child presented with three simultaneous malignancies: glioblastoma multiforme, Burkitt lymphoma, and colonic adenocarcinoma. She was treated for her diseases without success and died 8 months after presentation. Genetic analysis revealed a homozygous mutation in the PMS2 gene, consistent with constitutional mismatch repair deficiency. Her siblings and parents were screened: three of four siblings and both parents were heterozygous for this mutation; the fourth sibling did not have the <!‐‐mutation. Pediatr Blood Cancer 2013;9999:1–2. © 2013 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - June 1, 2013 Category: Cancer & Oncology Authors: Andrew W. Walter, Sara Ennis, Hunter Best, Cecily P. Vaughn, Jeffrey J. Swensen, Amanda Openshaw, Karen W. Gripp Tags: Brief Report Source Type: research

[Review] Reproductive organ involvement in non-Hodgkin lymphoma during pregnancy: a systematic review
Data for pregnancy-associated non-Hodgkin lymphoma are limited to case reports, making it difficult to define this disorder. We did a systematic search for articles published between 1967 and 2011 with the aim to determine the characteristics, management, and outcome of pregnancy-associated non-Hodgkin lymphoma. We identified 121 patients from 74 papers. Most patients with stage information available presented with stage IV disease (75%, 82 of 108 patients). Patients were classified into three clinical groups; those with indolent lymphomas accounted for 5% (five of 108), aggressive lymphomas (diffuse large B-cell lymphoma ...
Source: The Lancet Oncology - June 1, 2013 Category: Cancer & Oncology Authors: Netanel A Horowitz, Noam Benyamini, Kristina Wohlfart, Benjamin Brenner, Irit Avivi Tags: Review Source Type: research

Unusual Presentation of Ewing Sarcoma in the Adrenal Gland: A Secondary Malignancy from a Survivor of Burkitt Lymphoma
The occurrence of Ewing sarcoma as a secondary malignancy is an extremely rare event in long-term cancer survivors. In addition, the occurrence of Ewing sarcoma in the adrenal gland is highly unusual. In this case report, we treated a 20-year-old male patient with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and methotrexate and cytarabine chemotherapy following a diagnosis of Stage IV Burkitt lymphoma. Following complete remission, he had been maintained for 2 years without evidence of disease. However, a regular follow-up computed tomography scan found a left adrenal gland mass and a biopsy revealed positiv...
Source: Japanese Journal of Clinical Oncology - May 27, 2013 Category: Cancer & Oncology Authors: Lim, S. H., Lee, J. Y., Lee, J. Y., Kim, J. H., Choi, K. H., Hyun, J. Y., Ko, Y. H., Lee, J., Kim, S. J., Kim, W. S. Tags: Case Report Source Type: research

Usefulness of a Monoclonal ERG/FLI1 Antibody for Immunohistochemical Discrimination of Ewing Family Tumors.
Abstract Ewing family tumors (EFTs) and prostate carcinomas are characterized by rearrangement of ETS genes, most commonly FLI1 (EFTs) and ERG (prostate carcinomas). Previously, we characterized an antibody against ERG (EPR3864) for detecting ERG-rearranged prostate carcinoma. Because EPR3864 also cross-reacts with FLI1, we evaluated the usefulness of EPR3864 for discriminating EFTs from other small round blue cell tumors (SRBCTs) with immunohistochemistry. Of 57 evaluable EFTs, 47 (82%) demonstrated at least moderate, diffuse, nuclear ERG/FLI1 staining (including 89% and 100% of cases with confirmed EWSR1:FLI1 and...
Source: American Journal of Clinical Pathology - May 26, 2013 Category: Pathology Authors: Tomlins SA, Palanisamy N, Brenner JC, Stall JN, Siddiqui J, Thomas DG, Lucas DR, Chinnaiyan AM, Kunju LP Tags: Am J Clin Pathol Source Type: research

Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review.
Abstract Double-hit or triple-hit B-cell lymphomas (DHL and THL) are rare subtype lymphomas usually associated with poor prognosis. It is defined by two or three recurrent chromosome translocations; MYC/8q24 loci, usually in combination with the t (14; 18) (q32; q21) bcl-2 gene or/and BCL6/3q27 chromosomal translocation. DHL was often observed both in de-novo diffuse large B cell lymphomas (DLBCL). It is otherwise unclassifiable, showing features intermediate that of large B-cell lymphoma and Burkitt lymphoma. Here, we present two follicular lymphoma patients; one transformed to THL, another transformed to DHL. Bot...
Source: International Journal of Clinical and Experimental Pathology - May 25, 2013 Category: Pathology Authors: Xu X, Zhang L, Wang Y, Zhang Q, Zhang L, Sun B, Zhang Y Tags: Int J Clin Exp Pathol Source Type: research

Blockade of PI3K/AKT pathway enhances sensitivity of Raji cells to chemotherapy through down-regulation of HSP70
Up-regulation of heat shock protein 70 (HSP70) could be elicited primarily by heat in former studies, and this was proved to be associated with cancer progression. Burkitt's lymphoma is one of highly aggressive B-cell non-Hodgkin's lymphoma and is one of the fastest growing human tumors. To investigate the effect of HSP70 expression on the sensitivity of human Burkitt lymphoma cells (Raji cells) to chemotherapy and its role in the involvement of PI3K/AKT pathway, we evaluated the effects of LY294002, a PI3K inhibitor, on the expression of HSP70 and cell sensitivity to adriamycin (ADM) or cisplatin (DDP). In present study, ...
Source: Cancer Cell International - May 24, 2013 Category: Cancer & Oncology Authors: Xiaosheng FangYujie JiangLili FengHaiping ChenChangqing ZhenMei DingXin Wang Source Type: research

Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease -- a combined tissue microarray, in vitro and in vivo study
Conclusions: Targeting mTOR activity may be a potential therapeutic tool in lymphomas. The presence of mTOR activity probably indicates that the inclusion of mTOR inhibition in the therapy of Hodgkin-lymphomas may be feasible and beneficial, especially when standard protocols are ineffective, and it may also allow dose reduction in order to decrease late treatment toxicity. Most likely, the combination of mTOR inhibitors with other agents will offer the highest efficiency for achieving the best clinical response. (Source: BMC Cancer)
Source: BMC Cancer - May 22, 2013 Category: Cancer & Oncology Authors: Ágnes MárkMelinda HajduZsófia VáradiTamás SticzNoémi NagyJudit CsomorLajos BercziViktória VargaMonika CsókaLászló KopperAnna Sebestyén Source Type: research

BAF complexes facilitate decatenation of DNA by topoisomerase IIα
Nature advance online publication 22 May 2013. doi:10.1038/nature12146 Authors: Emily C. Dykhuizen, Diana C. Hargreaves, Erik L. Miller, Kairong Cui, Andrey Korshunov, Marcel Kool, Stefan Pfister, Yoon-Jae Cho, Keji Zhao & Gerald R. Crabtree Recent exon-sequencing studies of human tumours have revealed that subunits of BAF (mammalian SWI/SNF) complexes are mutated in more than 20% of all human malignancies, but the mechanisms involved in tumour suppression are unclear. BAF chromatin-remodelling complexes are polymorphic assemblies that use energy provided by ATP hydrolysis to regulate transcription through the control...
Source: Nature AOP - May 22, 2013 Category: Research Authors: Emily C. DykhuizenDiana C. HargreavesErik L. MillerKairong CuiAndrey KorshunovMarcel KoolStefan PfisterYoon-Jae ChoKeji ZhaoGerald R. Crabtree Tags: Letter Source Type: research

Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease ¿ a combined tissue microarray, in vitro and in vivo study
Conclusions: Targeting mTOR activity may be a potential therapeutic tool in lymphomas. The presence of mTOR activity probably indicates that the inclusion of mTOR inhibition in the therapy of Hodgkin-lymphomas may be feasible and beneficial, especially when standard protocols are ineffective, and it may also allow dose reduction in order to decrease late treatment toxicity. Most likely, the combination of mTOR inhibitors with other agents will offer the highest efficiency for achieving the best clinical response. (Source: BMC Cancer)
Source: BMC Cancer - May 22, 2013 Category: Cancer & Oncology Authors: Ágnes MárkMelinda HajduZsófia VáradiTamás SticzNoémi NagyJudit CsomorLajos BercziViktória VargaMonika CsókaLászló KopperAnna Sebestyén Source Type: research

BAF complexes facilitate decatenation of DNA by topoisomerase IIα
BAF complexes facilitate decatenation of DNA by topoisomerase IIα Nature 497, 7451 (2013). doi:10.1038/nature12146 Authors: Emily C. Dykhuizen, Diana C. Hargreaves, Erik L. Miller, Kairong Cui, Andrey Korshunov, Marcel Kool, Stefan Pfister, Yoon-Jae Cho, Keji Zhao & Gerald R. Crabtree Recent exon-sequencing studies of human tumours have revealed that subunits of BAF (mammalian SWI/SNF) complexes are mutated in more than 20% of all human malignancies, but the mechanisms involved in tumour suppression are unclear. BAF chromatin-remodelling complexes are polymorphic assemblies that use ener...
Source: Nature - May 22, 2013 Category: Research Authors: Emily C. DykhuizenDiana C. HargreavesErik L. MillerKairong CuiAndrey KorshunovMarcel KoolStefan PfisterYoon-Jae ChoKeji ZhaoGerald R. Crabtree Tags: Letter Source Type: research

Late extramedullary recurrence of adult onset Burkitt's lymphoma mimicking peritoneal carcinomatosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 14, 2013 Category: Hematology Authors: Preetesh Jain, Ohad Benjamini, Ellen Schlette, Deborah A. Thomas, Susan O'Brien Tags: Images in Hematology Source Type: research

Lentiviral Vector-Mediated siRNA Knockdown of c-MYC: Cell Growth Inhibition and Cell Cycle Arrest at G2/M Phase in Jijoye Cells.
Abstract Inhibition of c-MYC has been considered as a potential therapy for lymphoma treatment. We explored a lentiviral vector-mediated small interfering RNA (siRNA) expression vector to stably reduce c-MYC expression in B cell line Jijoye cells and investigated the effects of c-MYC downregulation on cell growth, cell cycle, and apoptosis in vitro. The expression of c-MYC mRNA and protein levels were inhibited significantly by c-MYC siRNA. The c-MYC downregulation resulted in the inhibition of cell proliferation and cell cycle arrest at G2/M phase, which was associated with decreased expression of cyclin B and cyc...
Source: Biochemical Genetics - May 9, 2013 Category: Genetics & Stem Cells Authors: Song A, Ye J, Zhang K, Sun L, Zhao Y, Yu H Tags: Biochem Genet Source Type: research

MYC status determination in aggressive B‐cell lymphoma: the impact of FISH probe selection
ConclusionsTaking into account the prognostic and therapeutic implications of the MYC translocation, probe design and limitations should be particularly kept in mind when interpreting MYC hybridization patterns. In our experience, detection of 8q24 abnormalities could be optimized by a two‐probe approach involving the application of both IGH‐MYC dual‐fusion and MYC break‐apart selected kits.This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - May 3, 2013 Category: Pathology Authors: AM Muñoz‐Mármol, C Sanz, G Tapia, R Marginet, A Ariza, JL Mate Tags: Original Article Source Type: research

[Expression pattern of hsa-miR-9 and its association with BCL6 in EBV-positive and EBV-negative Burkitt lymphoma cell lines].
Abstract OBJECTIVE: To investigate the differential expression pattern of hsa-miR-9 between EBV(-)positive and -negative Burkitt lymphoma cell lines and its association with BCL-6. METHODS: The expression of hsa-miR9 and BCL-6 mRNAs in EBV(+) Raji and EBV-Ramous cells in mRNA levels were detected using fluorescence quantitative PCR (QRT-PCR). The two cells lines were transiently transfected with hsa-mir9-inhibitor and hsa-mir9-minicsvia Oligofectamine 2000, and the changes in BCL6 expressions was detected using QRT-PCR and Western blotting. Annexin V/PI staining was used to analyze the apoptosis and morphologic...
Source: Journal of Southern Medical University - May 1, 2013 Category: Universities & Medical Training Authors: Dai XZ, Chen SH, Ge J, Han XQ, Zhou XH, Wu ZQ, Zhao T Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Re‐expression of microRNA‐150 induces EBV‐positive Burkitt lymphoma differentiation by modulating c‐Myb in vitro
Burkitt lymphoma (BL) is a highly aggressive B‐cell lymphoma that includes two forms of BL differing in Epstein–Barr virus (EBV) infection status, EBV‐positive and EBV‐negative. Although many efforts, such as high‐intensity, short‐duration combination chemotherapy, have been devoted to improving therapy for this rapidly proliferating neoplasm, there are still significant treatment‐associated toxicities. Therefore, there remains a need for novel effective therapeutic strategies. MicroRNAs play a role in “fine tuning” the physiological and pathological differentiation process, by which cells can rapidly reg...
Source: Cancer Science - April 28, 2013 Category: Cancer & Oncology Authors: Shaohong Chen, Zhiqiang Wang, Xinzhen Dai, Jianhua Pan, Juan Ge, Xiqun Han, Zijing Wu, Xinhua Zhou, Tong Zhao Tags: Original Article Source Type: research

A Boy With Burkitt Lymphoma Associated With Noonan Syndrome Due to a Mutation in RAF1
This article reports on an association between Burkitt lymphoma and Noonan syndrome (NS) due to a RAF1 gene mutation. The patient was a 7‐year‐old boy with NS, who was included in the first series reporting the association between Noonan and RAF1, and who later presented with a 2‐week history of asymptomatic unilateral tonsillar swelling and ipsilateral cervical lymphadenopathy. Histological and biological examinations of the tonsillar biopsy led to the diagnosis of Burkitt lymphoma. While there is a well‐established association between NS and solid cell tumors, this is the first case described in the literature of...
Source: American Journal of Medical Genetics Part A - April 23, 2013 Category: Genetics & Stem Cells Authors: Paola Cianci, Valentina Tono, Alessandra Sala, Laura Locatelli, Claudio Carta, Carmelo Rizzari, Andrea Biondi, Angelo Selicorni Tags: Clinical Report Source Type: research

Primary endobronchial Burkitt's lymphoma in a child: A case report
Abstract: Primary endobronchial tumors are rare in children and often are misdiagnosed, resulting in a delay of appropriate treatment. Here, we present a case of 4-year-old girl with primary endobronchial lymphoma who presented with persistent pneumonia despite medical treatment. Her chest radiograph showed left atelectasis, and a bronchial foreign body was initially suspected. Bronchoscopic examination demonstrated a granulomatous tumor occupying the left main bronchus. Localized Burkitt's lymphoma in the left trachea was diagnosed histopathologically. This case emphasizes the consideration of endobronchial tumor and bron...
Source: International Journal of Pediatric Otorhinolaryngology - April 22, 2013 Category: ENT & OMF Authors: Taisuke Kobayashi, Masamitsu Hyodo, Nobumitsu Honda Tags: Case reports Source Type: research

Thymoquinone Efficiently Inhibits the Survival of EBV-Infected B Cells and Alters EBV Gene Expression
In this study, the modulator activity of the potent herbal extract drug thymoquinone on EBV was assessed in vitro. Thymoquinone was tested for cytotoxicity on human cells of lymphoblastoid cells, Raji Burkitt’s lymphoma, DG-75 Burkitt’s lymphoma, peripheral blood mononuclear cells, and periodontal ligament fibroblast. Apoptosis induction was analyzed via TUNEL assay and activity studies of caspase-3. The effect of thymoquinone on EBV gene expression was determined using real-time polymerase chain reaction. We report here, for the first time, a promising selective inhibitory affect of thymoquinone on EBV-infecte...
Source: Integrative Cancer Therapies - April 18, 2013 Category: Cancer & Oncology Authors: Zihlif, M. A., Mahmoud, I. S., Ghanim, M. T., Zreikat, M. S., Alrabadi, N., Imraish, A., Odeh, F., Abbas, M. A., Ismail, S. I. Tags: Articles Source Type: research

B‐cell lymphoma, unclassifiable, with features intermediate between diffuse large B‐cell lymphoma and burkitt lymphoma: study of 39 cases
Summary B‐cell lymphoma, unclassifiable (B‐UCL), with features intermediate between diffuse large B‐cell lymphoma and Burkitt lymphoma, is a poorly characterized entity. Therefore, we investigated cases of B‐UCL treated by the Nebraska Lymphoma Study Group (NLSG). We searched the NLSG registry for years 1985–2010 for cases of B‐UCL. Immunohistochemical stains and fluorescence in situ hybridization studies for MYC, BCL2 and BCL6 gene rearrangements were performed. Among the 39 cases studied, 54% were male and 46% were female, with a median age of 69 years. The majority of patients presented with advanced‐stag...
Source: British Journal of Haematology - April 18, 2013 Category: Hematology Authors: Anamarija M. Perry, David Crockett, Bhavana J. Dave, Pamela Althof, Lisa Winkler, Lynette M. Smith, Patricia Aoun, Wing C. Chan, Kai Fu, Timothy C. Greiner, Phillip Bierman, Robert Gregory Bociek, Julie M. Vose, James O. Armitage, Dennis D. Weisenburger Tags: Research Paper Source Type: research

Increased Expression of CIP2A in Aggressive Subtypes of B‐cell Lymphomas
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - April 17, 2013 Category: Pathology Authors: Laura Lilja, Kirsi‐Maria Haapasaari, Risto Bloigu, Tarja Salonen, Ari Ristimäki, Taina Turpeenniemi‐Hujanen, Outi Kuittinen Tags: Correspondence Source Type: research

'Mum, have I got cancer?': Boy, 7, who helped his mother overcome breast cancer is diagnosed with a rare form of the disease
Wendy Schmidt, from Cardiff, said it was her son Morgan's 'hugs and cuddles' that helped her cope with the stress of cancer. But he too has now been diagnosed with the rare cancer Burkitt Lymphoma. (Source: the Mail online | Health)
Source: the Mail online | Health - April 10, 2013 Category: Consumer Health News Source Type: news

Imaging of Burkitt's lymphoma-abdominal manifestations
Hanuman Satishchandra, Aralaguppe S Sridhar, Basavaradhya P PoojaJournal of Cancer Research and Therapeutics 2013 9(1):128-130Burkitt's lymphoma is an uncommon form of non-Hodgkin lymphoma in adults. The diagnostic workup for Burkitt's lymphoma includes radiological imaging and like any other form of non-Hodgkin's lymphoma definitive diagnosis is by histopathology. Imaging is necessary to determine the distribution and severity in terms of extent and organs of involvement to further assist in staging and thence to implement appropriate therapy. High incidence of intraabdominal involvement is seen in Am...
Source: Journal of Cancer Research and Therapeutics - April 10, 2013 Category: Cancer & Oncology Authors: Hanuman SatishchandraAralaguppe S SridharBasavaradhya P Pooja Source Type: research

Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies.
Abstract The role of cyclooxygenase-2 (COX-2), its lipid metabolite prostaglandin E2 (PGE2), and Eicosanoid (EP) receptors (EP; 1-4) underlying the proinflammatory mechanistic aspects of Burkitt's lymphoma, nasopharyngeal carcinoma, cervical cancer, prostate cancer, colon cancer, and Kaposi's sarcoma (KS) is an active area of investigation. The tumorigenic potential of COX-2 and PGE2 through EP receptors forms the mechanistic context underlying the chemotherapeutic potential of nonsteroidal anti-inflammatory drugs (NSAIDs). Although role of the COX-2 is described in several viral associated malignancies, the biolog...
Source: Translational Research : the journal of laboratory and clinical medicine - April 6, 2013 Category: Laboratory Medicine Authors: Paul AG, Chandran B, Sharma-Walia N Tags: Transl Res Source Type: research

Carnitine-Acyltransferase System Inhibition, Cancer Cell Death, and Prevention of Myc-Induced Lymphomagenesis
Conclusions Our data indicate that it is possible to tackle c-myc–driven tumorigenesis by altering lipid metabolism and exploiting the neoplastic cell addiction to FA oxidation. (Source: JNCI)
Source: JNCI - April 2, 2013 Category: Cancer & Oncology Authors: Pacilli, A., Calienni, M., Margarucci, S., D'Apolito, M., Petillo, O., Rocchi, L., Pasquinelli, G., Nicolai, R., Koverech, A., Calvani, M., Peluso, G., Montanaro, L. Tags: Article Source Type: research

A case of catheter-related bloodstream infection caused by Mycobacterium phocaicum
We present a patient with double hit Burkitt's like lymphoma who developed a catheter-related bloodstream infection due to Mycobacterium phocaicum that was identified by rpoB gene sequencing. His infection resolved with 7 weeks of antibiotics and port-a-cath removal. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 27, 2013 Category: Microbiology Authors: Jacques Simkins, Joseph D. Rosenblatt Tags: Case Reports Source Type: research

Re‐expression of miR‐150 induces EBV‐positive Burkitt lymphoma differentiation by modulating c‐Myb in vitro
Summary Burkitt lymphoma (BL) is a highly aggressive B‐cell lymphoma including 2 forms of BL differing in Epstein‐Barr virus (EBV) infection status: EBV‐positive and EBV‐negative BL. Recent years, although many efforts, such as high‐intensity, short‐duration combination chemotherapy, have been devoted to improve therapy for this rapidly proliferating neoplasm, there are still significant treatment‐associated toxicities. Therefore, there remains a need for novel effective therapeutic strategies. MicroRNAs (miRNAs) play a role of “fine tuning” in the physiological and pathological differentiation process, b...
Source: Cancer Science - March 25, 2013 Category: Cancer & Oncology Authors: Shaohong Chen, Zhiqiang Wang, Xinzhen Dai, Jianhua Pan, Juan Ge, Xiqun Han, Zijing Wu, Xinhua Zhou, Tong Zhao Tags: Original Article Source Type: research

A case of primary pancreatic Burkitt's lymphoma diagnosed by EUS-guided FNA
An 86-year-old man was seen with jaundice and abdominal pain. Magnetic resonance imaging revealed a mass in the head of the pancreas, with a homogeneous low signal on T1- and T2-weighted images; the main pancreatic duct was observed clearly within the mass and was without caliber variation (). Positive emission tomography/CT showed uptake in the pancreas and peripancreatic lymph nodes. EUS-FNA was performed with a 19-gauge needle and revealed a proliferation of small to medium atypical lymphocytes amid a starry-sky appearance on staining with hematoxylin and eosin. The atypical lymphocytes were positive for CD20 and CD10 a...
Source: Gastrointestinal Endoscopy - March 25, 2013 Category: Gastroenterology Authors: So Nakaji, Nobuto Hirata, Shigenobu Yoshimura, Toshiyasu Shiratori, Masayoshi Kobayashi, Eiji Ishii, Kosei Matsue Tags: At the Focal Point Source Type: research

Transformation from follicular lymphoma to biphasic high-grade large B-cell lymphoma with immunophenotypically and genetically distinct diffuse large B cell and Burkitt-like components
Transformation of follicular lymphoma (FL) into high-grade B-cell non-Hodgkin lymphoma, usually diffuse large B-cell lymphoma (DLBCL), occurs in 25–35% of patients.1 This transformation has been shown to occur as a result of gain of MYC (8q24) rearrangement in addition to the t(14;18)(q32;q21), leading to a ‘double-hit’ lymphoma.2–10 Indeed, 5% of all FL with a BCL2 breakpoint will acquire a MYC rearrangement during the course of the disease.2 Double-hit lymphomas with MYC and BCL2 rearrangements have overexpression of BCL2 (a potent anti-apoptotic protein) and MYC (an enhancer of cell proliferation...
Source: Journal of Clinical Pathology - March 14, 2013 Category: Pathology Authors: Dunn, R. G., Foot, N. J., Ffolkes, L., Newell, B., Wilkins, B. S., Neat, M. J. Tags: PostScript Source Type: research

Epstein–Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979–2009
Burkitt lymphoma (BL) occurs at all ages, but the patterns of Epstein–Barr virus (EBV) positivity in relation to human immunodeficiency virus (HIV), immunoprofiles and age have not been fully explored. BL tissues from residual tissue repositories, and two academic centers in the United States were examined by expert hematopathologists for morphology, immunohistochemistry, MYC rearrangement, EBV‐encoded RNA (EBER), and diagnosed according to the 2008 WHO lymphoma classification. Analysis was done using frequency tables, Chi‐squared statistics, and Student's t‐test. Of 117 cases examined, 91 were confirmed as BL. The...
Source: APMIS - March 1, 2013 Category: Research Authors: Sam M. Mbulaiteye, Sheeja T. Pullarkat, Bharat N. Nathwani, Lawrence M. Weiss, Nagesh Rao, Benjamin Emmanuel, Charles F. Lynch, Brenda Hernandez, Vishala Neppalli, Debra Hawes, Myles G. Cockburn, Andre Kim, Makeda Williams, Sean Altekruse, Kishor Bhatia, Tags: Original Article Source Type: research

Burkitt Lymphoma Risk in US Solid Organ Transplant Recipients
Investigators identified patients in the US Transplant Cancer Match Study who developed Burkitt’s lymphoma following solid organ transplantation and found that there was a significant increased incidence... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - February 22, 2013 Category: Cancer & Oncology Source Type: research

Acute kidney injury and inflammatory immune reconstitution syndrome in mixed genotype (A/E) hepatitis B virus co-infection in HIV-associated lymphoma.
We report a first case of HIV-associated lymphoma (HAL) presenting with acute kidney injury (AKI) and inflammatory immune reconstitution syndrome (IRIS). A 39-year-old male, treated with nonsteroidal anti-inflammatory drugs (NSAIDs) for one month prior to admission, developed AKI, left testicular tumor, and recurrent swelling of the right parotid gland. A resected testicular tumor exhibited features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Renal biopsy showed hydro-degeneration of renal tubules, interstitial inflammatory cells, and a small number of lymphoma cells in the sub-capsule, compati...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Tajima K, Kohno K, Shiono Y, Suzuki I, Kato Y, Hiroshima Y, Yamamoto M, Ohtake H, Iwaba A, Yamakawa M, Kato T Tags: Int J Clin Exp Pathol Source Type: research

Epidemiology of cancers in Niger, 1992 to 2009.
Abstract The present study aims to determine the various epidemiological characteristics of cancers in Niger from 1992 to 2009. It is a retrospective and descriptive study led from the data of the National cancers Register of Niger country between 1992 and 2009. During that period, 7,031 cases of cancers were collected. The number of registered patients suffering from cancers significantly increased, from 186 cases in 1992 to 646 cases in 2009. The ascendancy was feminine with a sex-ratio of 1.40. The average age was of 43 ± 17.53 years. The majority of the patients (70.2%) lived from the Niamey area. The bre...
Source: Bulletin du Cancer - February 18, 2013 Category: Cancer & Oncology Authors: Garba SM, Zaki HM, Arfaoui A, Hami H, Soulaymani A, Nouhou H, Quyou A Tags: Bull Cancer Source Type: research

TGF-{beta} Induces PUMA in Myc-driven Lymphomas [Cell Biology]
c-Myc transformed human Burkitt's lymphoma (BL) cells are highly sensitive to TGF-β-induced apoptosis. Previously we demonstrated that TGF-β-mediated cell death in BL cells is regulated via the mitochondrial intrinsic apoptosis pathway, which is dependent on the activation of BAX and/or BAK. TGF-β directly induces transcription of the BH3-only protein BIK and represses expression of the pro-survival factor BCL-XL but has no effect on the direct BAX/BAK “activators” BIM or BID (tBID). Here we show that TGF-β induces the BH3-only activator PUMA to aid induction of the intrinsic cell death pathway. TGF-β also induced...
Source: Journal of Biological Chemistry - February 15, 2013 Category: Chemistry Authors: Spender, L. C., Carter, M. J., O'Brien, D. I., Clark, L. J., Yu, J., Michalak, E. M., Happo, L., Cragg, M. S., Inman, G. J. Tags: Signal Transduction Source Type: research

Descriptive epidemiology of cancers in Cote d'Ivoire.
This study research aimed at describing the epidemiological features of cancers in Cote d'Ivoire. It is a 26-year retrospective and descriptive study focusing on all cancers confirmed histologically by using the data from the registers of Anatomic Pathology laboratory of Abidjan teaching hospitals. The parameters of the study were frequency, age, sex, site and histological type. We obtained 12,841 cancers within patients aged from 2 months to 107 years old along with 51.26-year median age and 0.9 as sex-ratio. The most important cancer locations are cervix (17.41%) followed by skin (15.81%), prostate (7.73%), breast (6...
Source: Bulletin du Cancer - February 14, 2013 Category: Cancer & Oncology Authors: Effi AB, Koffi KE, Aman NA, Doukouré B, N'dah KJ, Koffi KD, Kouyaté M, Koui BB, Hondé M, Diomandé MI Tags: Bull Cancer Source Type: research

Isolated Bilateral Cranial Nerve Three Palsy as Unique Manifestation of CNS Spread of Burkitt Lymphoma (P01.058)
CONCLUSIONS: Thus, this case illustrates an atypical presentation of presumed CNS infiltration of Burkitt lymphoma, with a non-diagnostic work-up, which responded to radiation treatment. This may suggest a role for radiation therapy when CNS spread is suspected clinically despite a lack of positive confirmatory diagnostic testing.Disclosure: Dr. Damian has nothing to disclose. Dr. Lambert has nothing to disclose. Dr. Laneuville has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Damian, A., Lambert, C., Laneuville, P. Tags: P01 Neurologic Manifestations: Therapeutics Source Type: research

Dose-Intensive Chemotherapy Including Rituximab in Burkitt's Leukemia or Lymphoma Regardless of Human Immunodeficiency Virus Infection Status: Final Results of a Phase 2 Study (Burkimab)
In a phase II study, Spanish authors concluded that dose-intensive chemotherapy with rituximab is effective in both HIV-positive and HIV-negative patients with Burkitt’s lymphoma. Abstract Background:... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - February 13, 2013 Category: Cancer & Oncology Source Type: research

Burkitt lymphoma risk after transplantation highlighted
Solid organ transplant recipients have a significant risk for developing Burkitt lymphoma (BL), US researchers have found. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - February 12, 2013 Category: Cancer & Oncology Source Type: news

Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing
chreiber, P Rosenstiel, A Franke & R Siebert (Source: Leukemia)
Source: Leukemia - February 1, 2013 Category: Hematology Authors: B KreckJ RichterO AmmerpohlM BarannD EsserB S PetersenI VaterE M Murga PenasC A Bormann ChungS SeisenbergerV Lee BoydS SmallwoodH G DrexlerR A F MacLeodM HummelF KruegerR HäslerS SchreiberP RosenstielA FrankeR Siebert Source Type: research

"Atypical rearrangement involving 3[prime]-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression"
The t(8;14)(q24.1;q32), the cytogenetic hallmark of Burkitt's lymphoma, is also found, but rarely, in cases of chronic lymphocytic leukemia (CLL). Such translocation typically results in a MYC-IGH@ fusion subsequently deregulating and overexpressing MYC on der 14q32. In CLL, atypical rearrangements resulting in its gain or loss, within or outside of IGH@ or MYC locus, have been reported, but their clinical significance remains uncertain. Herein, we report a 67 year-old male with complex cytogenetic findings of apparently balanced t(8;14) and unreported complex rearrangements of IGH@ and MYC loci. His clinical, morphologica...
Source: Molecular Cytogenetics - February 1, 2013 Category: Molecular Biology Authors: Ina AmarilloPeter BuiSibel KantarciNagesh RaoBrit ShackleyRolando GarcíaCarlos Tirado Source Type: research

Colorimetric In Situ Hybridization Identifies MYC Gene Signal Clusters Correlating With Increased Copy Number, mRNA, and Protein in Diffuse Large B-Cell Lymphoma.
In this study, we sought to further characterize these clusters of MYC signals by determining whether the presence of these correlated with other genetic features, mRNA levels, protein, and overall survival. We found that MYC clusters correlated with an abnormal MYC locus and with increased mRNA. MYC mRNA correlated with protein levels, and both increased mRNA and protein correlated with poorer overall survival. MYC clusters were seen in both the germinal center and activated B-cell subtypes of DLBCL. Clusters of MYC signals may be an underappreciated, but clinically important, feature of aggressive B-cell lymphomas with p...
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Valentino C, Kendrick S, Johnson N, Gascoyne R, Chan WC, Weisenburger D, Braziel R, Cook JR, Tubbs R, Campo E, Rosenwald A, Ott G, Delabie J, Jaffe E, Zhang W, Brunhoeber P, Nitta H, Grogan T, Rimsza L Tags: Am J Clin Pathol Source Type: research

Intestinal perforation after treatment of Burkitt's lymphoma: Case report and review of the literature
We report a unique case of a pediatric patient with lymphoma-related intestinal perforation which was managed with a damage control laparotomy, discuss operative management strategies in these difficult cases, and provide a review of similar cases in the literature. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - February 1, 2013 Category: Surgery Authors: Sara C. Fallon, Michele S. Redell, Javier El-Bietar, Monica E. Lopez, Sanjeev A. Vasudevan, Mary L. Brandt Tags: Independent Case Reports Source Type: research

Atypical rearrangement involving 3[prime]-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression
The t(8;14)(q24.1;q32), the cytogenetic hallmark of Burkitt's lymphoma, is also found, but rarely, in cases of chronic lymphocytic leukemia (CLL). Such translocation typically results in a MYC-IGH@ fusion subsequently deregulating and overexpressing MYC on der 14q32. In CLL, atypical rearrangements resulting in its gain or loss, within or outside of IGH@ or MYC locus, have been reported, but their clinical significance remains uncertain. Herein, we report a 67 year-old male with complex cytogenetic findings of apparently balanced t(8;14) and unreported complex rearrangements of IGH@ and MYC loci. His clinical, morphologica...
Source: Molecular Cytogenetics - February 1, 2013 Category: Molecular Biology Authors: Ina AmarilloPeter BuiSibel KantarciNagesh RaoBrit ShackleyRolando GarcíaCarlos Tirado Source Type: research

Aberrant Lymphocyte Enhancer-Binding Factor 1 Expression Is Characteristic for Sporadic Burkitt's Lymphoma.
This study supports a functionally important role for LEF1 and its target genes in BLs. PMID: 23375451 [PubMed - as supplied by publisher] (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - January 30, 2013 Category: Pathology Authors: Walther N, Ulrich A, Vockerodt M, von Bonin F, Klapper W, Meyer K, Eberth S, Pukrop T, Spang R, Trümper L, Kube D Tags: Am J Pathol Source Type: research

Dose‐intensive chemotherapy including rituximab in Burkitt's leukemia or lymphoma regardless of human immunodeficiency virus infection status
CONCLUSIONS:Age‐adapted intensive immunochemotherapy is highly effective in both HIV‐negative and HIV‐positive patients, with a higher toxicity in the latter group. Poor general status and bone marrow involvement had a negative impact on survival. Cancer 2013;. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - January 29, 2013 Category: Cancer & Oncology Authors: Josep‐Maria Ribera, Olga García, Carlos Grande, Jordi Esteve, Albert Oriol, Juan Bergua, José González‐Campos, Ferran Vall‐llovera, Mar Tormo, Jesús‐Maria Hernández‐Rivas, Daniel García, Salut Brunet, Natalia Alonso, Pere Barba, Pilar Mira Tags: Original Article Source Type: research