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This page shows you the latest news and research items in this category.

A disease‐specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: Results of a randomized, controlled, multicenter trial
CONCLUSIONEnteral nutrition with EPA and DHA may be advantageous in patients with head and neck or esophageal cancer by improving parameters of nutritional and functional status during CRT. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - June 13, 2013 Category: Cancer & Oncology Authors: Rainer Fietkau, Victor Lewitzki, Thomas Kuhnt, Tobias Hölscher, Clemens‐F. Hess, Bernhard Berger, Thomas Wiegel, Claus Rödel, Marcus Niewald, Robert M. Hermann, Dorota Lubgan Tags: Original Article Source Type: research

Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells.
This study investigated Polo-like kinase 1, a mitotic regulator often overexpressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia. Polo-like kinase 1 protein and Thr210 phosphorylation levels were higher in pediatric acute lymphoblastic leukemia (N=172) than in normal bone marrow mononuclear cells (N=10) (p<0.0001). High Polo-like kinase 1 protein phosphorylation, but not expression, was associated with a lower probability of event-free survival (p=0.042) and was a borderline significant prognostic factor (p=0.065) in a multivar...
Source: Haematologica - June 10, 2013 Category: Hematology Authors: Hartsink-Segers SA, Exalto C, Allen M, Williamson D, Clifford SC, Horstmann M, Caron HN, Pieters R, Den Boer ML Tags: Haematologica Source Type: research

Atypical Ovarian Calcifications Associated With Bilateral Borderline Ovarian Tumors
(Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - May 28, 2013 Category: Radiology Authors: Zeligs, K. P., Javitt, M. C., Barner, R., Hamilton, C. A. Tags: Clinical Letters Source Type: research

Mucinous borderline tumor involving fallopian tube: case report and review of the literature.
We report the case of a 74-year-old woman with a primary mucinous borderline tumor of the fallopian tube coexisting with an ovarian mucinous borderline tumor. Data were obtained through histopathologic study of the excised surgical specimen. p53, estrogen receptor (ER) and PAX8 expression were evaluated by immunohistochemistry on the available right fallopian tube and ovary. Both the ovarian and fallopian tube borderline ovarian tumors were negative for p53, ER and PAX8. However, the staining pattern highlighted the transition from a normal ciliated cell to neoplastic epithelia in the fallopian tube fimbria. This is the fi...
Source: International Journal of Clinical and Experimental Pathology - May 25, 2013 Category: Pathology Authors: Liu F, Wei J, Shen D, Liu J Tags: Int J Clin Exp Pathol Source Type: research

Complicated postoperative recovery increases omission, delay and discontinuation of adjuvant chemotherapy in patients with colon cancer stage III
ConclusionAge was the most important predictive factor for receiving adjuvant chemotherapy. However, at all ages, complicated postoperative recovery negatively influenced the administration of chemotherapy to stage III colon cancer patients, as well as a timely start and completion of chemotherapy.This article is protected by copyright. All rights reserved. (Source: Colorectal Disease)
Source: Colorectal Disease - May 17, 2013 Category: Gastroenterology Authors: L.G.M. Geest, J.E.A. Portielje, M.W.J.M. Wouters, N.I. Weijl, B.C. Tanis, R.A.E.M. Tollenaar, H. Struikmans, J.W.R. Nortier, Tags: Original Article Source Type: research

Phyllodes tumours of the breast: the role of CD34, vascular endothelial growth factor and β‐catenin in histological grading and clinical outcome
ConclusionCD34, VEGF and β‐catenin play biological roles in breast phyllodes tumours and may reveal insights into tumour progression, with differential expression accompanying higher grades.This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - May 7, 2013 Category: Pathology Authors: Soo Keng Ho, Aye Aye Thike, Poh Yian Cheok, Gary Man‐Kit Tse, Puay Hoon Tan Tags: Original Article Source Type: research

Claudin‐18 over expression in intestinal‐type mutinous borderline tumor of the ovary
ConclusionsClaudin‐18‐positivity is a specific phenotype that is characteristic of IMBTs. Frequent and diffuse expression of gastric markers, along with less frequent and usually focal expression of intestinal markers in IMBTs suggests that they are essentially composed of gastrointestinal‐type mucinous epithelium (gastric‐type epithelium with a variable degree of intestinal differentiation).This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - May 6, 2013 Category: Pathology Authors: Sultan Ahmad Halimi, Daichi Maeda, Aya Shinozaki Ushiku, Takahiro Koso, Keisuke Matsusaka, Mariko Tanaka, Takahide Arimoto, Katsutoshi Oda, Kei Kawana, Tetsu Yano, Tomoyuki Fujii, Masashi Fukayama Tags: Original Article Source Type: research

HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia
Conclusions: HPV prevalence (82%) in cervical cancer is at the lower range of the worldwide estimation (85 - 99%). While XRCC1 G399A was significantly associated with cervical cancer, TP53 G72C showed borderline association only in HPV-positive patients. Deviation from HWE in HPV-positive patients indicates co-selection, hence implicating the combination of HPV and SNPs in cancer predisposition. Thus, SNPs could be more relevant biomarkers of susceptibility to cervical cancer when associated with HPV infection. (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - May 4, 2013 Category: Cancer & Oncology Authors: Ghazi AlsbeihNajla Al-HarbiMedhat El-SebaieIsmail Al-Badawi Source Type: research

The Hysterectomy Association May Newsletter 2013
Welcome to the May 2013 newsletter and it finally feels as if Spring has arrived, in fact I’m loving the fact that we have blue skies and some warm weather beating down on us finally. The only downside is that it does mean staying indoors to work when I’d rather be outdoors enjoying myself. Hopefully it will be good at the weekend too. Hysteria Short Story Writing Competition 2013 The 1st April saw the launch of this years short story writing competition for women only. The winner of last years competition was Jane Thickett with her story ‘Banana Loaf: A recipe for solace; and you can find her story and ...
Source: The Hysterectomy Association - May 2, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Latest News Newsletters clinical trial covance hysteria 1 hysteria 2013 writing competition in my own owns: women's experiences of hysterectomy kickstarter Source Type: news

Abdominopelvic washings: A comprehensive review
This article provides a comprehensive and contemporary review of abdominopelvic washings in the evaluation of gynecologic and non-gynecologic tumors, including primary peritoneal and mesothelial entities. (Source: CytoJournal)
Source: CytoJournal - April 24, 2013 Category: Pathology Authors: Erika F RodriguezSara E MonacoWalid KhalbussR Marshall AustinLiron Pantanowtiz Source Type: research

Plasma 25‐hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case–control study
Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case–control studies indicate that circulating 25‐hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case–control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1,391 incident breast cancer cases and 1,391 controls. Multivariable conditional logistic regression models did not reveal a significant overall association between season‐standar...
Source: International Journal of Cancer - April 22, 2013 Category: Cancer & Oncology Authors: Tilman Kühn, Rudolf Kaaks, Susen Becker, Piia‐Piret Eomois, Françoise Clavel‐Chapelon, Marina Kvaskoff, Laure Dossus, Anne Tjønneland, Anja Olsen, Kim Overvad, Jenny Chang‐Claude, Annekatrin Lukanova, Brian Buijsse, Heiner Boeing, Antonia Trichop Tags: Epidemiology Source Type: research

Prognostic value of tissue protein expression levels of MIB‐1 (Ki‐67) in Danish ovarian cancer patients. From the ‘MALOVA’ ovarian cancer study
In conclusion, our results predict that an increased level of MIB‐1 (Ki‐67) expression in tumour tissue, points to a less favourable outcome for OC patients. (Source: APMIS)
Source: APMIS - April 18, 2013 Category: Research Authors: Mel C. Heeran, Claus K. Høgdall, Susanne K. Kjaer, Lise Christensen, Allan Jensen, Jan Blaakaer, IB Jarle Christensen, Estrid V.S. Høgdall Tags: Original Article Source Type: research

Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence
Conclusion: CCAT1 is up-regulated across the colon adenoma-carcinoma sequence. This up-regulation is evident in pre-malignant conditions and through all disease stages, including advanced metastatic disease suggesting a role in both tumorigenesis and the metastatic process. (Source: BMC Cancer)
Source: BMC Cancer - April 17, 2013 Category: Cancer & Oncology Authors: Bilal AlaiyanNadia IlyayevAlexander StojadinovicMina IzadjooMarina RoistacherVera PavlovVictoria TzivinDavid HalleHonguang PanBarry TrinkAli GureAviram Nissan Source Type: research

HDlive imaging of a serous borderline ovarian tumor
(Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - April 9, 2013 Category: Radiology Authors: M. Grigore Tags: Picture of the Month Source Type: research

Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies
Conclusions We found that the protective effects of tubal ligation on ovarian cancer risk were subtype-specific. These findings provide insights into distinct aetiologies of ovarian cancer subtypes and mechanisms underlying the protective effects of tubal ligation. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - April 8, 2013 Category: Epidemiology Authors: Sieh, W., Salvador, S., McGuire, V., Weber, R. P., Terry, K. L., Rossing, M. A., Risch, H., Wu, A. H., Webb, P. M., Moysich, K., Doherty, J. A., Felberg, A., Miller, D., Jordan, S. J., Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer St Tags: Other Original Articles Source Type: research

Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer Is Effective and Well Tolerated
Purpose: Stereotactic body radiation therapy (SBRT) provides high rates of local control (LC) and margin-negative (R0) resections for locally advanced pancreatic cancer (LAPC) and borderline resectable pancreatic cancer (BRPC), respectively, with minimal toxicity.Methods and Materials: A single-institution retrospective review was performed for patients with nonmetastatic pancreatic cancer treated with induction chemotherapy followed by SBRT. SBRT was delivered over 5 consecutive fractions using a dose painting technique including 7-10 Gy/fraction to the region of vessel abutment or encasement and 5-6 Gy/fraction to the re...
Source: International Journal of Radiation Oncology * Biology * Physics - April 8, 2013 Category: Radiology Authors: Michael D. Chuong, Gregory M. Springett, Jessica M. Freilich, Catherine K. Park, Jill M. Weber, Eric A. Mellon, Pamela J. Hodul, Mokenge P. Malafa, Kenneth L. Meredith, Sarah E. Hoffe, Ravi Shridhar Tags: Gastrointestinal Cancers Source Type: research

[Methods and conditions of fertility preservation in early-stage ovarian tumors].
Abstract The aim of this study is to review the literature of fertility-sparing techniques and their safety in early-stage malignant ovarian tumors, especially in epithelial ovarian cancer. Fertility preservation is widely accepted in early-stage borderline, germ cell and sex cord-stromal tumors. Based on data from retrospective studies, fertility-sparing surgery in epithelial ovarian cancer can be recommended in stage IA, grade 1-2 and favorable hystologic type ovarian cancer. Above stage IA, or in grade 3, or in clear-cell tumors decision making process about fertility-sparing surgery should be individual. Correc...
Source: Orvosi Hetilap - April 7, 2013 Category: Journals (General) Authors: Szatmári E, Máté S, Sipos N, Szánthó A, Silhavy M, Rigó J Tags: Orv Hetil Source Type: research

The diagnostic utility of TP53 and CDKN2A to distinguish ovarian high-grade serous carcinoma from low-grade serous ovarian tumors
oger & Martin Köbel (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - April 5, 2013 Category: Pathology Authors: Alon D AltmanGregg S NelsonPrafull GhatageJohn B McIntyreDavid CapperPamela ChuJill G NationAnthony N KarnezisGuangming HanSteve E KallogerMartin Köbel Tags: CDKN2A high-grade serous carcinoma low-grade serous carcinoma ovarian carcinoma serous borderline tumor TP53 Source Type: research

Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study
Conclusion(s): We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.Earn online CME credit related to this document at www.asrm.org/elearn (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 2, 2013 Category: Reproduction Medicine Authors: Albert Asante, Phoebe H. Leonard, Amy L. Weaver, Ellen L. Goode, Jani R. Jensen, Elizabeth A. Stewart, Charles C. Coddington Tags: Infertility Source Type: research

Advanced Stage Epithelial Ovarian Borderline Neoplasm in an Adolescent: A Case Report and Review of the Literature
We report an advanced stage serous borderline tumor in an adolescent and summarize the literature to date. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2013 Category: OBGYN Authors: Roshanak Mansouri, Matthew L. Anderson, Jennifer E. Dietrich Tags: Poster Abstracts Source Type: research

Epitheloid hemangioendothelioma of the palpebral lobe of the lacrimal gland.
CONCLUSION: Epitheloid hemangioendothelioma can occur in the palpebral lobe of the lacrimal gland as a hard, painless, immobile mass. Simple excisional biopsy of the tumor, assumed to have an intermediate malignancy grade, without further local or systemic therapy provided a disease-free 3-year survival. PMID: 23514025 [PubMed - in process] (Source: Orbit)
Source: Orbit - April 1, 2013 Category: Opthalmology Authors: Kiratli H, Tarlan B, Ruacan S Tags: Orbit Source Type: research

Early stage epithelial ovarian cancers: A study of morphologic prognostic factors.
In conclusion, FIGO-stage is the most reliable prognosticator. Although prognostic value of universal grade is not significant, mitotic count may provide important prognostic information for early-stage ovarian carcinomas. PMID: 23643734 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 30, 2013 Category: Pathology Authors: Terzi A, Aktaş IY, Dolgun A, Ayhan A, Küçükali T, Usubütün A Tags: Pathol Res Pract Source Type: research

Imaging in gynecological disease (8): ultrasound characteristics of recurrent borderline ovarian tumors
ConclusionSonographic features of recurrent BOT resemble those described by others for different subtypes of primary BOT. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - March 25, 2013 Category: Radiology Authors: D. Franchi, S. Boveri, R. Fruscio, D. Fischerova, S. Guerriero, M. C. Moruzzi, N. Colombo, D. Timmerman, L. Valentin, A. C. Testa Tags: Original Paper Source Type: research

Plasma 25(OH)vitamin D and the risk of breast cancer in the european prospective investigation into cancer and nutrition (EPIC): A nested case‐control study
ABSTRACT Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. While the results of case‐control studies indicate that circulating 25‐hydroxyvitamin D (25(OH)D) is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case‐control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1391 incident breast cancer cases and 1391 controls. Multivariable conditional logistic regression models did not reveal a significant overall association between season‐sta...
Source: International Journal of Cancer - March 23, 2013 Category: Cancer & Oncology Authors: Tilman Kühn, Rudolf Kaaks, Susen Becker, Piia‐Piret Eomois, Françoise Clavel‐Chapelon, Marina Kvaskoff, Laure Dossus, Anne Tjønneland, Anja Olsen, Kim Overvad, Jenny Chang‐Claude, Annekatrin Lukanova, Brian Buijsse, Heiner Boeing, Antonia Trichop Tags: Epidemiology Source Type: research

Borderline Tumour and Full Abdominal Hysterectomy – Jackie’s Story
I had my surgery last year; I had a 10cm growth on my right ovary which was a borderline tumour, I had a full abdominal hysterectomy, and also had my appendix removed. I am pleased to say that the histology came back clear, so it is onwards and upwards from here. I was cut from just above my belly button, right down to my nether regions, and had clips in which were removed after 10 days. Post op I had two pain bombs which were fed directly into the wound. I had my op first thing in the morning, and only got to the ward after 4pm as I apparently took a long time to come round, I was on oxygen overnight and IV pain rel...
Source: The Hysterectomy Association - March 20, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Latest News Your Stories hints and tips total abdominal hysterectomy tumour Source Type: news

Phyllodes Tumors of the Breast: Ultrasonographic Findings and Diagnostic Performance of Ultrasound-Guided Core Needle Biopsy
Abstract: We evaluated ultrasonography (US) findings between benign and malignant phyllodes tumors and analyzed diagnostic performance of US-guided core needle biopsy (CNB) for phyllodes tumors. Surgically removed phyllodes tumors of 168 women were divided into two groups according to the benign and malignant (including borderline tumor) groups and 116 were benign and 52 were malignant. On US, the complex cystic echogenicity (p = 0.021), presence of cleft (p = 0.005) and higher final US assessment (p = 0.008) were more frequent in the malignant group. The sensitivity of CNB including fibroepithelial tumors was 67.9% (11...
Source: Ultrasound in Medicine and Biology - March 18, 2013 Category: Radiology Authors: Inyoung Youn, Seon Hyeong Choi, Hee Jung Moon, Min Jung Kim, Eun-Kyung Kim Tags: Original Contributions Source Type: research

Sonographic predictors of ovarian malignancy
Conclusions.In the absence of high or intermediate risk sonographic features, the risk of malignancy is low. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013; (Source: Journal of Clinical Ultrasound)
Source: Journal of Clinical Ultrasound - March 16, 2013 Category: Radiology Authors: Lisa Barroilhet, Allison Vitonis, Thomas Shipp, Michael Muto, Beryl Benacerraf Tags: Research Article Source Type: research

Borderline tumours of the ovary: A cohort study of the Arbeitsgmeinschaft Gynäkologische Onkologie (AGO) Study Group
Abstract: Background: Borderline ovarian tumours (BOTs) are recognised as a unique entity of ovarian tumours that do not exert infiltrative destructive growth or stromal invasion. Prognosis of BOT is much better compared to the more common invasive epithelial ovarian cancer. Information regarding prognostic factors is inconclusive and no prospective studies exist that evaluate therapeutic strategies. We therefore started a retrospective–prospective cohort study to better understand BOT and identify scenarios in which future studies could be developed.Methods: Consecutive patients with BOT treated between 1998 and 2008 in...
Source: European Journal of Cancer - March 14, 2013 Category: Cancer & Oncology Authors: Andreas du Bois, Nina Ewald-Riegler, Nikolaus de Gregorio, Alexander Reuss, Sven Mahner, Christina Fotopoulou, Friedrich Kommoss, Barbara Schmalfeldt, Felix Hilpert, Tanja Fehm, Alexander Burges, Werner Meier, Peter Hillemanns, Lars Hanker, Annette Hasenb Tags: Gynecologic oncology Source Type: research

[Endometriosis as a risk factor for ovarian cancer].
Abstract A history of endometriosis is a risk factor for some subtypes of epithelial ovarian cancer. Endometriosis is associated with increased risk of ovarian clear cell, serous low-grade endometrioid cancer, but it is unclear what the role of endometriosis is in the development of other histopathological subtypes of ovarian cancer, such as high-grade serous borderline tumors subtypes or borderline serous and mucinous cancers. An understanding of the mechanisms leading to malignant transformation of endometriosis will be needed to identify subgroups of women at increased risk of ovarian cancer. This is important b...
Source: Cirugia y Cirujanos - March 1, 2013 Category: Surgery Authors: Vargas-Hernández VM Tags: Cir Cir Source Type: research

Diversity in size and signal intensity in multilocular cystic ovarian masses: New parameters for distinguishing metastatic from primary mucinous ovarian neoplasms
Conclusion:Bilateral tumors were more common among metastatic tumors, which tended to be composed of cysts of uniform sizes and signal intensities compared with those of primary mucinous tumors. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - February 25, 2013 Category: Radiology Authors: Yumiko Oishi Tanaka, Satoshi Okada, Toyomi Satoh, Koji Matsumoto, Akinori Oki, Tsukasa Saida, Hiroyuki Yoshikawa, Manabu Minami Tags: Original Research Source Type: research

Homocysteine, cysteine, and risk of incident colorectal cancer in the Women's Health Initiative observational cohort.
CONCLUSION: High plasma homocysteine is associated with increased risk of CRC, whereas high cysteine is associated with decreased risk. This trial was registered at clinicaltrials.gov as NCT 00000611. PMID: 23426034 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - February 20, 2013 Category: Nutrition Authors: Miller JW, Beresford SA, Neuhouser ML, Cheng TY, Song X, Brown EC, Zheng Y, Rodriguez B, Green R, Ulrich CM Tags: Am J Clin Nutr Source Type: research

Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options
CONCLUSIONS This systematic review underlines that fertility subsequent to treatment of BOT depends mainly on histology and initial staging to distinguish early from advanced stages. In patients with advanced stage BOT, several alternative options to conservative management are available to allow patients to conceive without compromising their prognosis. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 19, 2013 Category: OBGYN Authors: Darai, E., Fauvet, R., Uzan, C., Gouy, S., Duvillard, P., Morice, P. Tags: Reviews Source Type: research

[Duodenum-preserving total pancreatic head resection : An organ-sparing operation technique for cystic neoplasms and non-invasive malignant tumors.]
[Duodenum-preserving total pancreatic head resection : An organ-sparing operation technique for cystic neoplasms and non-invasive malignant tumors.] Chirurg. 2013 Feb 17; Authors: Beger HG, Siech M, Poch B Abstract Cystic neoplasms of the pancreas are being detected and surgically treated increasingly more frequently. Intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN) are primary benign lesions; however, the 5-year risk for malignant transformation has been estimated to be 63 % and 15 %, respectively. Surgical extirpation of a benign cystic tumor of the pancreas is a cance...
Source: Der Chirurg - February 17, 2013 Category: Surgery Authors: Beger HG, Siech M, Poch B Tags: Chirurg Source Type: research

Smoking is associated with lower age, higher grade, higher stage, and larger size of malignant bladder tumors at diagnosis
Smoking is a strong risk factor of bladder cancer (BC), but it is currently unclear whether smoking is also associated with severity of BC at diagnosis. We performed a large hospital‐based case‐comparison study, examining the relation between smoking and clinical characteristics of BC at diagnosis. A total of 1,544 cases from participating hospitals in the West Midlands were recruited between 19 December 2005 and 21 April 2011. Eligible cases were adult BC patients without a previous history of this disease. At time of diagnosis, semi‐structured face‐to‐face interviews were conducted by trained research nurses to...
Source: International Journal of Cancer - February 13, 2013 Category: Cancer & Oncology Authors: Eline H. van Roekel, Kar K. Cheng, Nicholas D. James, D. Michael A. Wallace, Lucinda J. Billingham, Paul G. Murray, Richard T. Bryan, Maurice P. Zeegers Tags: Epidemiology Source Type: research

Neoadjuvant chemoradiation therapy for borderline pancreatic adenocarcinoma: report of two cases
We report on the first two BRPT cases treated with neoadjuvant chemoradiation at our institution. Preoperative CT and MRI demonstrated pancreatic tumors encasing the porto-mesenteric confluence suggestive of BRPT. Patients received neoadjuvant chemotherapy (gemcitabine/cisplatin), followed by radiochemotherapy. After treatment, follow-up images demonstrated tumor downsize, allowing for the tumors to be considered then as resectable. They underwent partial pancreatoduodenectomies (Whipple procedure). In case 1, histopathology revealed a complete, margin-free resection, whereas in case 2 there was a complete pathological res...
Source: World Journal of Surgical Oncology - February 5, 2013 Category: Cancer & Oncology Authors: José GalindoMauricio GabrielliJuan GuerraJuan CassinaMarcelo GarridoNicolás JarufeYerko BorgheroJorge MadridPablo ZoroquiainJuan RoaJorge Martínez Source Type: research

In vitro fertilization is associated with an increased risk of borderline ovarian tumors.
CONCLUSIONS: Women undergoing IVF treatment are at increased risk of being diagnosed with borderline ovarian tumors. Risk factors for borderline ovarian tumors appear different from those for invasive ovarian cancer. PMID: 23385152 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 2, 2013 Category: Cancer & Oncology Authors: Stewart LM, Holman CD, Finn JC, Preen DB, Hart R Tags: Gynecol Oncol Source Type: research

Evaluation of MMP2 and Caspase-3 expression in 107 cases of papillary thyroid carcinoma and its association with prognostic factors.
In this study, 107 cases of PTC with known histological properties, including vascular or capsular invasion, were assessed for expression of MMP2 and Caspase-3 using immunohistochemistry. Considering 10% as a cutoff to discriminate cases with invasive behavior from the non-invasive group, there was no relationship between expression of MMP2 or Caspase-3 in tumor cells and the presence of capsular invasion (p=0.45 and 0.64, respectively), as well as for the expression of Caspase-3 and vascular invasion (p=0.43). In case of MMP2, a borderline correlation was found between the positive reaction of tumor cells with the presenc...
Source: Pathology, Research and Practice - February 2, 2013 Category: Pathology Authors: Saffar H, Sanii S, Emami B, Heshmat R, Panah VH, Azimi S, Tavangar SM Tags: Pathol Res Pract Source Type: research

Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients.
CONCLUSIONS: GnRHa administration before and during chemotherapy in borderline ovarian tumor and ovarian cancer patients who had undergone fertility preservation operation may bring up higher rates of spontaneous resumption of menses and a better pregnancy rate. Long-term follow up and large scale clinical studies are required. PMID: 23422190 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - February 1, 2013 Category: Journals (General) Authors: Zhu HL, Wang Y, Li XP, Wang CH, Wang Y, Cui H, Wang JL, Wei LH Tags: Chin Med J (Engl) Source Type: research

Laparoscopic restaging of borderline ovarian tumours (BLOT): a retrospective study of 142 cases
Abstract: Objectives: Primary objective: To analyse the impact of restaging, on recurrences and survival, in BLOT. Secondary objective: To cluster patients who could be exempted from restaging.Study design: This retrospective study, included patients operated for a BLOT, between January 1990, and December 2007, in gynaecological surgery units of the University Hospital of Clermont-Ferrand.Two groups were evaluated: patients with and without optimal restaging.Results: One hundred and forty-two patients were included. Optimal initial staging rate was 38.7% (n=55). Among the eighty-seven women not initially staged, two groups...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 30, 2013 Category: OBGYN Authors: A.S. Azuar, N. Bourdel, G. Ferrarrese, J. Dauplat, G. Mage, M. Canis Tags: Gynecology and Gynecological Oncology Source Type: research

The DNA Methylomes of Serous Borderline Tumors Reveal Subgroups With Malignant- or Benign-Like Profiles.
Abstract Serous borderline tumors (SBOTs) are a challenging group of ovarian tumors positioned between benign and malignant disease. We have profiled the DNA methylomes of 12 low-grade serous carcinomas (LGSCs), 19 SBOTs, and 16 benign serous tumors (BSTs) across 27,578 CpG sites to further characterize the epigenomic relationship between these subtypes of ovarian tumors. Unsupervised hierarchical clustering of DNA methylation levels showed that LGSCs differ distinctly from BSTs, but not from SBOTs. Gene ontology analysis of genes showing differential methylation at linked CpG sites between LGSCs and BSTs revealed ...
Source: The American Journal of Pathology - January 25, 2013 Category: Pathology Authors: Zeller C, Dai W, Curry E, Siddiq A, Walley A, Masrour N, Kitsou-Mylona I, Anderson G, Ghaem-Maghami S, Brown R, El-Bahrawy M Tags: Am J Pathol Source Type: research

HDlive Pictures of a Serous Ovarian Borderline Tumor
We present HDlive pictures from a case of a serous BOT in a 25‐year‐old patient. Using HDlive technology allowed increased depth perception, and thus, provided a clear view of the tumor content and papillae, as well as the extent of papillae inside the tumor. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - January 24, 2013 Category: Radiology Authors: Mihaela Grigore Tags: Picture of the month Source Type: research

HDlive Pictures of a Serous Ovarian Borderline Tumor.
We present HDlive pictures from a case of a serous BOT in a 25-year-old patient. Using HDlive technology allowed increased depth perception, and thus, provided a clear view of the tumor content and papillae, as well as the extent of papillae inside the tumor. PMID: 23349045 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - January 24, 2013 Category: Radiology Authors: Grigore M Tags: Ultrasound Obstet Gynecol Source Type: research

Incomplete staging surgery as a major predictor of relapse of borderline ovarian tumor
Conclusions: Complete staging surgery should be considered a cornerstone of BOT treatment in order to minimize the risk of relapse. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - January 23, 2013 Category: Cancer & Oncology Authors: Margarita RomeoFrancesc PonsPilar BarretinaJoaquim Radua Source Type: research

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
Conclusions: We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community. (Source: BMC Cancer)
Source: BMC Cancer - January 22, 2013 Category: Cancer & Oncology Authors: Linda KelemenElisa BanderaKathryn TerryMary RossingLouise BrintonJennifer DohertyRoberta NessSusanne KjærJenny Chang-ClaudeMartin KöbelGalina LuriePamela ThompsonMichael CarneyKirsten MoysichRobert EdwardsClare BunkerAllan JensenEstrid HøgdallDaniel Cr Source Type: research

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
Background: Epithelial ovarian cancer is one of the leading causes of gynaecological cancer morbidity and mortality in women. Early stage ovarian cancer is usually asymptomatic, therefore, is often first diagnosed when it is widely disseminated. Currently available diagnostics lack the requisite sensitivity and specificity to be implemented as community-based screening tests. The identification of additional biomarkers may improve the diagnostic efficiency of multivariate index assays. The aims of this study were to characterise and compare the ovarian tissue immunohistochemical localisation and plasma concentrations of th...
Source: Journal of Ovarian Research - January 22, 2013 Category: Cancer & Oncology Authors: Ratana LimMartha LappasClyde RileyNiels BorregaardHolger MollerNuzhat AhmedGregory Rice Source Type: research

Hemangioendothelioma
is the term used to name those vascular neoplasms that show a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. Although originally spindle cell hemangioendothelioma was proposed as a specific clinicopathologic variant of hemangioendothelioma, currently, it is considered as an entirely benign lesion, and thus, the name spindle cell hemangioma seems to be the most accurate for this lesion. Authentic hemangioendotheliomas involving the skin and soft tissues include papillary intralymphatic angioendothelioma (also known as Dabska tumor), retiform hemangioendo...
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Luis Requena, Heinz Kutzner Source Type: research

Preoperative radiotherapy and local excision of rectal cancer with immediate radical re-operation for poor responders: A prospective multicentre study.
CONCLUSIONS: This study suggests an acceptable local recurrence rate after preoperative radiotherapy and local excision of small, radiosensitive tumours in elderly patients. PMID: 23333016 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 16, 2013 Category: Radiology Authors: Bujko K, Richter P, Smith FM, Polkowski W, Szczepkowski M, Rutkowski A, Dziki A, Pietrzak L, Kołodziejczyk M, Kuśnierz J, Gach T, Kulig J, Nawrocki G, Radziszewski J, Wierzbicki R, Kowalska T, Meissner W, Radkowski A, Paprota K, Polkowski M, Rychter A Tags: Radiother Oncol Source Type: research

Detection of a Unilateral Mucinous Borderline Ovarian Tumor With Sonography and Magnetic Resonance Imaging
Various modalities of diagnostic imaging have been proven to be adequate in the characterization and diagnosis of ovarian neoplasms. This case study investigates a unique form of mucinous borderline ovarian tumor consisting of both intestinal and Müllerian types. Borderline tumors are considered an intermediate form of neoplasm between the benign and malignant form. Shortly after sonographic and magnetic resonance imaging, the large tumor was removed and the patient was determined to have an excellent prognosis. The utilization of sonography in diagnosing this tumor is discussed, demonstrating the significance of the ...
Source: Journal of Diagnostic Medical Sonography - January 14, 2013 Category: Radiology Authors: Hennessey, A. Tags: Case Studies Source Type: research

Does pre‐operative chemoradiation for initially unresectable or borderline resectable pancreatic adenocarcinoma increase post‐operative morbidity? A case‐matched analysis
ConclusionAlthough some previous studies have suggested differences in post‐operative morbidity after chemoradiation, our case‐matched analysis did not find statistical differences in surgical morbidity and mortality associated with pre‐operative chemoradiation therapy. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 10, 2013 Category: Gastroenterology Authors: Raphael L. C. Araujo, Sébastien Gaujoux, Florence Huguet, Mithat Gonen, Michael I. D'Angelica, Ronald P. DeMatteo, Yuman Fong, T. Peter Kingham, William R. Jarnagin, Karyn A. Goodman, Peter J. Allen Tags: Original Article Source Type: research

Smoking is associated with lower age, higher grade, higher stage, and larger size of malignant bladder tumours at diagnosis
Abstract Smoking is a strong risk factor of bladder cancer (BC), but it is currently unclear whether smoking is also associated with severity of BC at diagnosis. We performed a large hospital‐based case‐comparison study, examining the relation between smoking and clinical characteristics of BC at diagnosis. A total of 1,544 cases from participating hospitals in the West Midlands were recruited between 19 December 2005 and 21 April 2011. Eligible cases were adult BC patients without a previous history of this disease. At time of diagnosis, semi‐structured face‐to‐face interviews were conducted by trained research ...
Source: International Journal of Cancer - January 7, 2013 Category: Cancer & Oncology Authors: Eline H. van Roekel, Kar K. Cheng, Nicholas D. James, D. Michael A. Wallace, Lucinda J. Billingham, Paul. G. Murray, Richard T. Bryan, Maurice P. Zeegers Tags: Epidemiology Source Type: research