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This page shows you the latest news and research items in this category.

Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options
CONCLUSIONS This systematic review underlines that fertility subsequent to treatment of BOT depends mainly on histology and initial staging to distinguish early from advanced stages. In patients with advanced stage BOT, several alternative options to conservative management are available to allow patients to conceive without compromising their prognosis. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 19, 2013 Category: OBGYN Authors: Darai, E., Fauvet, R., Uzan, C., Gouy, S., Duvillard, P., Morice, P. Tags: Reviews Source Type: research

Pathogenesis and the Role of ARID1A Mutation in Endometriosis-related Ovarian Neoplasms
Endometriosis-related ovarian neoplasms (ERONs) are a unique group of tumors as they are associated with endometriosis, especially endometriosis presenting as an ovarian endometriotic cyst (endometrioma). ERONs include clear cell carcinoma, endometrioid carcinoma, and seromucinous borderline tumor. A growing body of evidence from both clinicopathologic and molecular studies suggests that most, if not all, ERONs develop from endometriotic cyst epithelium through different stages of tumor progression. The endometriotic cyst contains abundant iron-induced reactive oxygen species that are thought to be mutagenic, and chronic e...
Source: Advances in Anatomic Pathology - December 29, 2012 Category: Pathology Tags: Review Articles Source Type: research

Second harmonic generation microscopy as a powerful diagnostic imaging modality for human ovarian cancer
In this study we showed that second‐harmonic generation (SHG) microscopy combined with precise methods for images evaluation can be used to detect structural changes in the human ovarian stroma. Using a set of scoring methods (alignment of collagen fibers, anisotropy, and correlation), we found significant differences in the distribution and organization of collagen fibers in the stroma component of serous, mucinous, endometrioid and mixed ovarian tumors as compared with normal ovary tissue. This methodology was capable to differentiate between cancerous and healthy tissue, with clear cut distinction between normal, beni...
Source: Journal of Biophotonics - October 1, 2012 Category: Physics Authors: Javier Adur, Vitor B. Pelegati, Andre A. de Thomaz, Mariana O. Baratti, Liliana A. L. A. Andrade, Hernandes F. Carvalho, Fátima Bottcher‐Luiz, Carlos Lenz Cesar Tags: Full Article Source Type: research

[Articles] Ovarian cancer and smoking: individual participant meta-analysis including 28 114 women with ovarian cancer from 51 epidemiological studies
The excess of mucinous ovarian cancers in smokers, which is mainly of tumours of borderline malignancy, is roughly counterbalanced by the deficit of endometrioid and clear-cell ovarian cancers. The substantial variation in smoking-related risks by tumour subtype is important for understanding ovarian carcinogenesis. (Source: The Lancet Oncology)
Source: The Lancet Oncology - August 29, 2012 Category: Cancer & Oncology Authors: Collaborative Group on Epidemiological Studies of Ovarian Cancer Tags: Articles Source Type: research

Cancerous ovarian stem cells: Obscure targets for therapy but relevant to chemoresistance
Abstract Chemotherapy with platinum and taxanes is the first line of treatment for all epithelial ovarian cancer (EOC) patients after debulking surgery. Even though the treatment is initially effective in 80% of patients, recurrent cancer is inevitable in the vast majority of cases. Emerging evidence suggests that some tumor cells can survive chemotherapy by activating the self‐renewal pathways resulting in tumor progression and clinical recurrence. These defined population of cells commonly termed as ‘cancer stem cells’ (CSC) may generate the bulk of the tumor by using differentiating pathways. These cells have been...
Source: Journal of Cellular Biochemistry - August 10, 2012 Category: Biochemistry Authors: Nuzhat Ahmed, Khalid Abubaker, Jock Findlay, Michael Quinn Tags: Prospects Source Type: research

Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes
AbstractInconsistent results for the role of dairy food intake in relation to ovarian cancer risk may reflect the potential adverse effects of lactose, which has been hypothesized to increase gonadotropin levels, and the beneficial antiproliferative effects of calcium and vitamin D. Using data from the New England case–control study (1,909 cases and 1,989 controls), we examined dairy foods and nutrients in relation to risk of ovarian cancer overall, histological subtypes and rapidly fatal versus less aggressive disease. We used logistic regression and polytomous logistic regression to estimate odds ratios (ORs) and 95% c...
Source: International Journal of Cancer - July 24, 2012 Category: Cancer & Oncology Authors: Melissa A. Merritt, Daniel W. Cramer, Allison F. Vitonis, Linda J. Titus, Kathryn L. Terry Tags: Epidemiology Source Type: research

Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis.
CONCLUSIONS: This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and epithelial ovarian cancer risk. PMID: 22449732 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 23, 2012 Category: Cancer & Oncology Authors: Rota M, Pasquali E, Scotti L, Pelucchi C, Tramacere I, Islami F, Negri E, Boffetta P, Bellocco R, Corrao G, La Vecchia C, Bagnardi V Tags: Gynecol Oncol Source Type: research

Management and prognosis of endometrioid borderline tumors of the ovary
Conclusion: Endometrioid borderline ovarian tumors carry a good prognosis. Most EBOT tumors are stage I, therefore surgical staging is not necessary in most of the cases. However, uterine curettage is required in cases of uterine preservation. (Source: Surgical Oncology)
Source: Surgical Oncology - March 14, 2012 Category: Surgery Authors: C. Uzan, R. Berretta, M. Rolla, S. Gouy, R. Fauvet, E. Darai, P. Duvillard, P. Morice Tags: General Papers Source Type: research

Histology‐specific long‐term trends in the incidence of ovarian cancer and borderline tumor in Japanese females: A population‐based study from 1983 to 2007 in Niigata
Conclusion: This prefecture‐wide study showed the practical trends in ovarian cancer and borderline tumors in Japanese females. The incidence of ovarian cancer has steadily increased, with significant increases in the incidence of clear cell and mucinous adenocarcinomas in the total population during the past two decades. Because of the poor response rate of these histological subtypes to platinum‐based regimens, novel treatment approaches should be adopted to improve the prognostic outcome in patients with ovarian cancer in Japan. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - March 2, 2012 Category: OBGYN Authors: Tetsuro Yahata, Chiaki Banzai, Kenichi Tanaka, Source Type: research

Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India
Conclusion: We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 19, 2012 Category: Cancer & Oncology Authors: Santosh Kumar MondalRanjana BanyopadhyayDipanwita Roy NagSuprio RoychowdhuryPalash Kumar MondalSwapan Kumar Sinha Source Type: research

Low‐grade serous carcinomas of the ovary contain very few point mutations
AbstractIt has been well established that ovarian low‐grade and high‐grade serous carcinomas are fundamentally different types of tumours. While the molecular genetic features of ovarian high‐grade serous carcinomas are now well known, the pathogenesis of low‐grade serous carcinomas, apart from the recognition of frequent somatic mutations involving KRAS and BRAF, is largely unknown. In order to comprehensively analyze somatic mutations in low‐grade serous carcinomas, we applied exome sequencing to the DNA of eight samples of affinity‐purified low‐grade serous carcinomas. A remarkably small number of mutation...
Source: The Journal of Pathology - November 21, 2011 Category: Pathology Authors: Siân JonesTian‐Li WangRobert J. KurmanKentaro NakayamaVictor E. VelculescuBert VogelsteinKenneth W. KinzlerNickolas PapadopoulosIe‐Ming Shih Tags: Original Paper Source Type: research

Accuracy of frozen section diagnosis of ovarian borderline tumor.
CONCLUSION: Comprehensive surgical staging can be considered in BT >8cm in diameter, as well as those with micropapillary serous, endometrioid, and clear cell histology diagnosed at the time of frozen section analysis. PMID: 21920591 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - September 13, 2011 Category: Cancer & Oncology Authors: Shih KK, Garg K, Soslow RA, Chi DS, Abu-Rustum NR, Barakat RR Tags: Gynecol Oncol Source Type: research

Epithelial Ovarian Carcinoma Types and the Coexistence of Ovarian Tumor Conditions
Conclusion. One in six patients with a malignant ovarian tumor has a coexisting epithelial tumor condition in the ovary, which is also rather frequently observed in the diagnostic work-up practice. (Source: Advances in Urology)
Source: Advances in Urology - July 14, 2011 Category: Urology & Nephrology Source Type: research

Epiregulin as a marker for the initial steps of ovarian cancer development.
Epiregulin (Ep) was found to be produced in non-cancer ovarian cells in response to gonadotropin stimulation as well in ovarian cancer cells in an autonomous manner. However, there were no systematic follow-up studies of Ep expression in the development of different stages of ovarian cancer. Using specific antibodies to Ep and the indirect immunocytochemistry methods, we found that in normal ovary the staining for Ep was mainly confined to the epithelial cells, while the stromal cells were only occasionally and moderately stained. In contrast in benign serous and mucinous tumors most of the tumor cells showed a clear s...
Source: International Journal of Oncology - July 13, 2011 Category: Cancer & Oncology Authors: Amsterdam A, Shezen E, Raanan C, Slilat Y, Ben-Arie A, Prus D, Schreiber L Tags: Int J Oncol Source Type: research

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis
Conclusion In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management. Content Type Journal ArticlePages 1-5DOI 10.1007/s00404-011-1957-zAuthors A. Kondi-Pafiti, Pathology Laboratory, University of Athens, Athens, GreeceE. Papakonstantinou, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Iavazzo, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Univer...
Source: Archives of Gynecology and Obstetrics - June 29, 2011 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Stage IA Ovarian Cancers: Comparison of Sonographic Findings and Histopathologic Types Between Patients With Normal and Elevated Serum Cancer Antigen 125 Levels
Conclusions— Stage IA ovarian cancers with normal CA-125 levels tend to be smaller, have less solid components, and have a slightly different distribution of histopathologic types than cancers with elevated CA-125 levels. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - June 23, 2011 Category: Radiology Authors: Hirai, M., Hirai, Y., Tsuchida, T., Takada, T., Iwase, H., Utsugi, K., Sugiyama, Y., Takeshima, N., Furuta, R., Takizawa, K. Tags: Original Research Source Type: research

Elevated Plasma Growth Differentiation Factor-15 Correlates with Lymph Node Metastases and Poor Survival in Endometrial Cancer.
CONCLUSION: Based on findings indicated in a primary investigation set and confirmed in the large secondary validation set, we report for the first time plasma GDF-15 as a biomarker for endometrial cancer phenotype, including presence of lymph node metastasis and reduced survival. Its applicability as predictor of metastatic nodes and in monitoring treatment of endometrial cancer needs to be further studied. PMID: 21616994 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - May 25, 2011 Category: Cancer & Oncology Authors: Staff AC, Trovik J, Eriksson AG, Wik E, Wollert KC, Kempf T, Salvesen H Tags: Clin Cancer Res Source Type: research

Histologic, Molecular, and Cytogenetic Features of Ovarian Cancers: Implications for Diagnosis and Treatment [Women's Imaging]
Ovarian epithelial carcinoma (OEC), the most common ovarian malignancy, is a heterogeneous disease with several histologic subtypes that show characteristic cytogenetic features, molecular signatures, oncologic signaling pathways, and clinical-biologic behavior. Recent advances in histopathology and cytogenetics have provided insights into pathophysiologic features and natural history of OECs. Several studies have shown that high- or low-grade serous, endometrioid, and clear cell carcinomas are characterized by mutations involving the TP53, K-ras/BRAF, CTNNB1, and PIK3CA genes, respectively. High-grade serous carcinomas, t...
Source: Radiographics recent issues - May 11, 2011 Category: Radiology Authors: Lalwani, N., Prasad, S. R., Vikram, R., Shanbhogue, A. K., Huettner, P. C., Fasih, N. Tags: Obstetric/Gynecologic Radiology, Molecular Imaging, Oncologic Imaging, Genitourinary Radiology Women's Imaging Source Type: research

Ovarian borderline tumours: a review with emphasis on controversial areas
Abstract: Ovarian borderline tumours are relatively uncommon, but by no means rare, neoplasms. Most are of serous or mucinous type with other morphological variants being much more uncommon. This review discusses the pathological features and some clinical aspects of ovarian borderline tumours, concentrating on those of serous and mucinous type. Borderline endometrioid, Brenner and clear cell tumours are briefly discussed. Controversial and often poorly understood topics covered include the relationship between borderline tumours and carcinomas, the criteria for and significance of microinvasion, the significance of a micr...
Source: Diagnostic Histopathology - March 29, 2011 Category: Pathology Authors: W. Glenn McCluggage Tags: Mini Symposium: Ovarian Pathology Source Type: research

Ovarian cancer arising in endometrioid cysts: ultrasound findings
ConclusionsBorderline tumors and carcinomas arising in endometrioid cysts show a vascularised solid component at ultrasound examination, and this figure was present in all malignant transformation. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - February 22, 2011 Category: Radiology Authors: AC TestaD TimmermanC Van HolsbekeGF ZannoniS FransisP MoermanV VelloneF MasciliniA LicameliM LudovisiA Di LeggeG ScambiaG Ferrandina Tags: Original Article Source Type: research

"Surface epithelial changes" in uterine endometrioid carcinoma mimicking micropapillary serous borderline tumor of ovary: report of two cases and review of the literature
This report expands the existing spectrum of SECs. Serous borderline tumor of ovary like surface epithelial changes could be misleading if present in an endometrial biopsy or curettings. Therefore, knowledge of this morphologic variation is important. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - January 26, 2011 Category: Pathology Authors: Kamaljeet SinghRochelle SimonCunxian ZhangM. Ruhul Quddus Source Type: research

Primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma
We present a 58-year-old woman with primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma. Noninvolved ovary showed no Brenner tumor, endometriosis, transitional carcinoma, endometrioid adenocarcinoma, or typical multigerm layer classic mature teratoma. Moreover, no other primary site was possible because there were no prior or concomitant squamous carcinomas, or history of cervical intraepithelial neoplasia. The tumor showed strong positivity for p63 and CK5/6, reactivity that also extended from the squamous carcinoma into the basal-cell lining of the mucinous cyst of a likely m...
Source: Annals of Diagnostic Pathology - October 11, 2010 Category: Pathology Authors: Mariah R. Baughn, Steven C. Plaxe, Noel Weidner Tags: Case Reports Source Type: research

Borderline ovarian endometrioid tumor in adolescent: case report and review of the literature
Os tumores endometrioides malignos ovarianos são neoplasias epiteliais raras em pacientes jovens. Enquanto os carcinomas endometrioides ovarianos acometem mulheres na quinta e na sexta décadas de vida, os tumores borderline acometem mulheres em uma faixa etária mais ampla (de 22 a 77 anos). Descreveremos a seguir um caso raro de tumor endometrioide borderline ocorrendo em paciente de 16 anos. Desde que tumores do saco vitelino (TSV) e de Sertoli-Leydig (TCSL) podem mimetizar morfologicamente tumor endometrioide, o uso da imuno-histoquímica, além dos aspectos morfológicos, foi fundamental para estabelecer o diagnósti...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - July 18, 2010 Category: Pathology Source Type: research

Recreational physical activity and risk of epithelial ovarian cancer
Conclusions Our findings are compatible with an overall reduction in risk of invasive epithelial ovarian cancer associated with recreational activity but suggest that this association may differ in women with different histologic types of disease. Inconsistent findings across studies that have considered histologic type indicate that this issue is not yet resolved. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9479-8Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred H...
Source: Cancer Causes and Control - December 1, 2009 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: research

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumors
Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - May 18, 2009 Category: Pathology Authors: Jin Hyung Heo, Kwang Il Kim, Sun Young Lee, Tae Heon Kim, Haeyoun Kang, Hee Jung An Source Type: research

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.
CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 9, 2009 Category: Cancer & Oncology Authors: Shimada M, Kigawa J, Ohishi Y, Yasuda M, Suzuki M, Hiura M, Nishimura R, Tabata T, Sugiyama T, Kaku T Tags: Gynecol Oncol Source Type: research

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors
Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinou...
Source: Human Pathology - March 8, 2009 Category: Pathology Authors: Masafumi Yasunaga, Yoshihiro Ohishi, Yoshinao Oda, Munechika Misumi, Atsuko Iwasa, Shuichi Kurihara, Izumi Nishimura, Emi Okuma, Hiroaki Kobayashi, Norio Wake, Masazumi Tsuneyoshi Tags: Original Contributions Source Type: research

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.
Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous bor...
Source: Human Pathology - March 6, 2009 Category: Pathology Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Tags: Hum Pathol Source Type: research

Ovarian epithelial dysplasia after ovulation induction: time and dose effects
CONCLUSIONS There is probably a relationship between ovarian epithelial dysplasia and either ovulation inducing drugs or infertility. By Fathalla’s incessant ovulation theory, ‘the dose effect and the time effect’ of ovarian stimulation may explain ovarian dysplasia formation. (Source: Human Reproduction)
Source: Human Reproduction - December 8, 2008 Category: Reproduction Medicine Authors: Chene, G., Penault-Llorca, F., Le Bouedec, G., Mishellany, F., Dauplat, M.M., Jaffeux, P., Aublet-Cuvelier, B., Pouly, J.L., Dechelotte, P., Dauplat, J. Tags: Infertility Source Type: research

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumors
Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - November 4, 2008 Category: Pathology Authors: Sung Ho Hwang, Sang Jae Noh, Hyong Jong Kwak, Kyung Ryoul Kim, Ho Sung Park, Woo Sung Moon, Myoung Ja Chung, Keun Sang Kwon, Kwan Sik Kim, Kyu Yun Jang Source Type: research

Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1
Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saita...
Source: Archives of Gynecology and Obstetrics - October 21, 2008 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery
Conclusions Our results suggest differences in the relation of ovarian cysts and endometriosis with risk of specific subtypes of ovarian cancer as well as the possibility that ovarian surgery in women with these conditions may lower the risk of invasive disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9207-9Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristin...
Source: Cancer Causes and Control - August 15, 2008 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: research

mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age difference
The objective of this study was to examine mtDNA sequence variants in 118 frozen tissues of three subtypes of epithelial ovarian cancer (serous, n=48 endometrioid, n=47 and mucinous, n =23) and matched paracancerous normal tissues (n= 18) in relation to racial/ethnic and age differences. Restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-based sequencing were used to evaluate two regions of mtDNA spanning 5317 to 7608 and 8282 to 10110 bp and including ND subunits 2, 3, MT-COI, II, and III, ATPase 8, a part of ATPase 6, and tRNA genes in frozen ovarian tissues obtained from the southern reg...
Source: BioMed Central - July 28, 2008 Category: Journals (General) Authors: Felix O Aikhionbare, Sharifeh Mehrabi, Winston Thompson, Xuebiao Yao, William Grizzle and Edward Partridge Source Type: research

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.
We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was pos...
Source: Cancer Control - June 14, 2008 Category: Cancer & Oncology Authors: Olsen CM, Nagle CM, Whiteman DC, Purdie DM, Green AC, Webb PM, Tags: Int J Cancer Source Type: research

Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors.
A novel class of putative progestin binding proteins has been recently identified as potential mediators of rapid nongenomic hormone actions. The proteins designated membrane progestin receptor (mPR) alpha, beta, and gamma were initially discovered in fish and shown to have a role in oocyte maturation. The predicted multiple membrane spanning domain structure of the mPRs resembles that of heptahelical G-protein-coupled receptors. Phylogenetic analysis indicated that the mPRs belong to the large progestin and adiponectin Q receptor (PAQR) gene family. Based on the reported expression of the 3 mPRs in hormone-responsive ...
Source: Human Pathology - May 12, 2008 Category: Pathology Authors: Romero-Sánchez M, Peiper SC, Evans B, Wang Z, Catasús L, Ribe A, Prat J, Giri JG Tags: Hum Pathol Source Type: research

Body size and risk of epithelial ovarian and related cancers: A population-based case-control study
We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was pos...
Source: International Journal of Cancer - April 30, 2008 Category: Cancer & Oncology Authors: Catherine M. Olsen, Christina M. Nagle, David C. Whiteman, David M. Purdie, Adèle C. Green, Penelope M. Webb, Australian Cancer Study (Ovarian Cancer) and Australian Ovarian Cancer Study Group Source Type: research

[My approach] My approach to and thoughts on the typing of ovarian carcinomas
Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each with a different underlying pathogenesis and natural behaviour. Accurate classification of ovarian carcinomas is important since each type may be associated with a different behaviour, natural history and outcome. Precise classification is also critical to determine whether alternative therapeutic strategies are appropriate for different tumour types. Previous studies have shown significant interobserver variation in the typing of ovarian carcinomas. There are several areas where there are particular difficulties; these include the dist...
Source: Journal of Clinical Pathology - January 25, 2008 Category: Pathology Authors: McCluggage, W G Tags: My approach Source Type: research

Atypical endometriosis: a clinicopathologic study of 163 cases
Conclusion AEM lesions have some features which are similar and also differ from both of the tumor and EM. AEMs have a relative higher potential for tumorigenesis and canceration, especially for ovarian cancer. The process of damage, repair, and scarring in EM foci over a long period may play a role in the development of EM into AEM and eventally into tumor formation. Content Type Journal ArticleDOI 10.1007/s11805-007-0405-0Authors Donghui Guo, Tianjin Central Obstetrics & Gynecology Hospital Department of Pathology Tianjin 300052 ChinaShujie Pang, Tianjin Central Obstetrics & Gynecology Hospital Depa...
Source: Chinese Journal of Clinical Oncology - January 13, 2008 Category: Cancer & Oncology Tags: Chinese Journal of Clinical Oncology Source Type: research

Overexpression of mammaglobin B in epithelial ovarian carcinomas.
CONCLUSIONS: Mammaglobin B gene is highly expressed in EOC and may represent a novel molecular marker for multiple histological types of ovarian cancer. Additional studies to evaluate the clinical utility of Mammaglobin B as a diagnostic and/or therapeutic target in ovarian cancer are warranted. PMID: 17343903 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 5, 2007 Category: Cancer & Oncology Authors: Tassi RA, Bignotti E, Rossi E, Falchetti M, Donzelli C, Calza S, Ravaggi A, Bandiera E, Pecorelli S, Santin AD Tags: Gynecol Oncol Source Type: research

Mitochondrial DNA sequence variants in epithelial ovarian tumor subtypes and stages
Conclusion: Our findings indicate that certain mtDNA mutations can reliably distinguish the different histologic subtypes of epithelial ovarian tumors. In addition, these data raise the possibility that certain mtDNA mutations may be useful biomarkers for predicting tumor aggressiveness and may play a potential role in tumorigenesis. (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - January 26, 2007 Category: Cancer & Oncology Authors: Felix O Aikhionbare, Sharifeh Mehrabi, K Kumaresan, Mojgan Zavareh, Moshood Olatinwo, Kunle Odunsi and Edward Partridge Source Type: research

Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer
The objectives of this study were to analyze the real role that these pathways play in ovarian cancer, to correlate them with clinicopathologic characteristics, and to identify the factors that transmit individual proliferation signals and are associated with pathologic grade and prognosis, regardless specific oncogenic alterations upstream.One hundred twenty-nine ovarian epithelial tumors were studied, including 20 serous cystadenomas, 7 mucinous cystadenomas, 11 serous borderline tumors, 16 mucinous borderline tumors, 29 serous carcinomas, 16 endometrioid carcinomas, 15 clear cell carcinomas, and 15 mucinous carcinomas. ...
Source: Cancer - September 19, 2006 Category: Cancer & Oncology Authors: Josep Castellvi, Angel Garcia, Federico Rojo, Carmen Ruiz-Marcellan, Antonio Gil, Jose Baselga, Santiago Ramon y Cajal Source Type: research