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This page shows you the latest news and research items in this category.

In Regard to Pinn-Bingham et al
To the Editor: We read with great interest the article by Pinn-Bingham et al on high-dose-rate interstitial brachytherapy in locally advanced cervical cancer. This is the largest study published to date in this regard after the study by Demanes et al and will definitely be of interest to the majority of practicing gynecologic oncologists worldwide. However, some points need to be argued in this study. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 25, 2013 Category: Radiology Authors: Ajeet Kumar Gandhi, Daya Nand Sharma, Goura Kisor Rath, Pramod Kumar Julka Tags: Comments Source Type: research

Correlation between biological marker expression and F-fluorodeoxyglucose uptake in cervical cancer measured by positron emission tomography.
CONCLUSION: The data presented in this study indicate that (18)F-FDG uptake is associated with the presence of GLUT1, VEGF, nuclear HK-II, and cytoplasmic HIF1α. There was also a significant correlation among the rate of expression of GLUT1, HK-II, cytoplasmic HIF1α, and CAIX in carcinomas of the cervix. PMID: 23548964 [PubMed - in process] (Source: Onkologie)
Source: Onkologie - May 24, 2013 Category: Cancer & Oncology Authors: Park SI, Suh DS, Kim SJ, Choi KU, Yoon MS Tags: Onkologie Source Type: research

Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells.
This study investigated DAS affected on cell-cycle regulation and apoptosis in human cervical cancer Ca Ski cells. DAS at 25-100 μM decreased the viability of Ca Ski cells by increasing G0/G1 phase arrest followed by induction of apoptosis in concentration- and time-dependent effects. Flow cytomteric assay indicated that DAS (75 μM) promoted the production of Ca(2+) accumulation and decreased the level of mitochondrial membrane potential in Ca Ski cells. Western blotting showed that 75 μM of DAS-induced G0/G1 phase arrest was mediated through the increased expression of p21, p27, and p53 with a simultaneous decrease in ...
Source: Nutrition and Cancer - May 24, 2013 Category: Cancer & Oncology Authors: Chiu TH, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS, Chung JG Tags: Nutr Cancer Source Type: research

A review of dietary prevention of human papillomavirus-related infection of the cervix and cervical intraepithelial neoplasia.
This study reviews the preventive role of dietary intake on cervical intraepithelial neoplasia (CIN) induced by human papillomavirus (HPV). Electronic databases were searched using relevant keywords such as, but not limited to, human papillomavirus infection, cervical intraepithelial neoplasia, lifestyle factors, nutrients intake, and diet. High consumption of fruit and vegetables appears to be protective against CIN. The findings also highlight the possibility of consuming high levels of specific nutrients, vitamins, and minerals, and retaining sufficient level of these elements in the body, especially those with high ant...
Source: Nutrition and Cancer - May 24, 2013 Category: Cancer & Oncology Authors: Chih HJ, Lee AH, Colville L, Binns CW, Xu D Tags: Nutr Cancer Source Type: research

Adaptive 3D Image-Guided Brachytherapy: A Strong Argument in the Debate on Systematic Radical Hysterectomy for Locally Advanced Cervical Cancer.
Conclusion. IGABT combined with CCRT provides excellent locoregional control rates with low treatment-related morbidity, justifying the elimination of hysterectomy in the absence of obvious residual disease. Distant metastasis remains an important first relapse and may warrant more aggressive systemic treatment. PMID: 23568003 [PubMed - in process] (Source: The Oncologist)
Source: The Oncologist - May 24, 2013 Category: Cancer & Oncology Authors: Mazeron R, Gilmore J, Dumas I, Champoudry J, Goulart J, Vanneste B, Tailleur A, Morice P, Haie-Meder C Tags: Oncologist Source Type: research

Difference in overall and age-specific prevalence of high-risk human papillomavirus infection in Italy: evidence from NTCC trial
Conclusions: Our results showed substantial differences in overall and age-specific HR-HPV prevalence across Italian areas. These findings may be related to different timing of changes in sexual behaviours across regions. Age-specific HR-HPV prevalence in Italy does not support an influence of age per se. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 24, 2013 Category: Infectious Diseases Authors: Iacopo BaussanoSilvia FranceschiAnna Gillio-TosFrancesca CarozziMassimo ConfortiniPaolo Dalla PalmaMargherita De LilloAnnarosa Del MistroLaura De MarcoCarlo NaldoniPaola PierottiPatrizia SchincagliaNereo SegnanManuel ZorziPaolo Giorgi-RossiGuglielmo Ronco Source Type: research

Screening for cervical cancer: a systematic review and meta-analysis
Conclusions: The available evidence supports the conclusion that cervical screening does offer protective benefits and is associated with a reduction in the incidence of invasive cervical cancer and cervical cancer mortality. (Source: BioMed Central)
Source: BioMed Central - May 24, 2013 Category: Journals (General) Authors: Leslea PeirsonDonna Fitzpatrick-LewisDonna CiliskaRachel Warren Source Type: research

Cervical Cancer Studies Take Center StageCervical Cancer Studies Take Center Stage
Dr. Maurie Markman predicts that ASCO 2013 will be a hotbed for gynecologic cancer research, including highly anticipated studies in ovarian cancer and plenary-featured studies in cervical cancer. Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

Pfizer takes its shot at a vaccine for evasive superbug
CHICAGO (Reuters) - Kathrin Jansen is a microbiologist with at least two breakthrough vaccines to her name: she brought the cervical cancer vaccine Gardasil to market for Merck and helped develop the $4 billion a year pneumonia and meningitis vaccine Prevnar 13 for Pfizer. (Source: Reuters: Health)
Source: Reuters: Health - May 23, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Intracardiac metastasis from known cervical cancer:a case report and literature review
We present a case of intracardiac metastasis arising from a squamous carcinoma of the cervix in a patient with pulmonary tumor emboli and review other cases from the literature. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - May 23, 2013 Category: Cancer & Oncology Authors: Seung Won ByunSung Taek ParkEun Young KiHyun SongSuk Hee HongJong Sup Park Source Type: research

Mammography use for breast cancer screening in Portugal: results from the 2005/2006 National Health Survey
Conclusions: This study provides useful information to improve the allocation of resources to breast cancer screening. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - May 22, 2013 Category: Journals (General) Authors: Dourado, F., Carreira, H., Lunet, N. Tags: Screening Source Type: research

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix
Conclusions: Nuclear TK1 expression in early grade CIN predicts risk for progression to malignancy. Nuclear TK1 expression is also a prognostic factor for treatment outcome, particularly in patients with advanced cervical carcinomas. Nuclear TK1 expression is more useful than Ki-67 and pathological/FIGO stages. (Source: BMC Cancer)
Source: BMC Cancer - May 21, 2013 Category: Cancer & Oncology Authors: Gang ChenCheng HeLing LiAn LinXiongwei ZhengEllen HeSven Skog Source Type: research

A phase II study of weekly neoadjuvant chemotherapy followed by radical chemoradiation for locally advanced cervical cancer
Feeney & J A Ledermann (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - May 21, 2013 Category: Cancer & Oncology Authors: M McCormackL KadalayilA HackshawM A Hall-CraggsR P SymondsV WarwickH SimondsI FernandoM HammondL JamesA FeeneyJ A Ledermann Source Type: research

Hysterectomy for cancer – Trudy’s Story
Hi, I have been off work for shoulder surgery work related. During that time I found out after my pap smear was abnormal that I needed a endometrial biopsy which confirmed uterine cancer. Less than a month after that I had a robotic total hysterectomy. Everything including my cervix was removed. The resident told me I would be off work 4 to 6 weeks. My work disability is giving me off till 5/28/13. I had this procedure on May 1st ,2013. I am still on light duty til 6/6/2013 for my shoulder. I am a nurse who works 12.5 hours a day but not every day. I push a med cart with a computer. Wash, turn, lift patients getting them ...
Source: The Hysterectomy Association - May 20, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Cancer Recovery Your Stories davinci hysterectomy return to work after hysterectomy robotic hysterectomy total hysterectomy Uterine Cancer Source Type: news

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation
Several reports have described the potential effects of natural compounds as anti-cancer agents in vitro as well as in vivo. The aim of this study was to evaluate the anti-cancer effect of Limoniastrum guyonianum aqueous gall extract (G extract) and luteolin in the human cervical cancer HeLa cell line, and, if so, to clarify the underlying mechanism. Our results show that G extract and luteolin inhibited cell proliferation and induced G2/M cell cycle arrest in a concentration and time-dependent manner. Both natural products induced programmed cell death as confirmed by the presence of hypodiploid G0/G1 cells. These effects...
Source: Journal of Experimental and Clinical Cancer Research - May 20, 2013 Category: Cancer & Oncology Authors: Mounira KrifaMahmoud AlhosinChristian MullerJean-Pierre GiesLeila Chekir-GhediraKamel GhediraYves MélyChristian BronnerMarc Mousli Source Type: research

THE GooseMan: A simulator for transhiatal esophagectomy
Esophageal cancer is the fastest growing cancer in the United States and the seventh leading cause of cancer-related death worldwide. The gold standard therapy is surgical resection commonly performed as a transhiatal esophagectomy (THE), which involves blindly dissecting the esophagus in the mediastinum through abdominal and cervical neck incisions. Compared with transthoracic esophagectomy, which requires creating a direct thoracic incision, THE has similar long-term survival but is less invasive and has fewer complications, a shorter recovery time, and decreased in-hospital mortality. Yet, morbidity and mortality from T...
Source: The Journal of Thoracic and Cardiovascular Surgery - May 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kanika Trehan, Xun Zhou, Yufei Tang, Doru Petrisor, Clinton D. Kemp, Stephen C. Yang Tags: Cardiothoracic Surgical Education and Training Source Type: research

Study Explores Providers' Perceptions Of Parental Concerns About HPV Vaccination
A new Boston University School of Medicine (BUSM) study has found that low-income and minority parents may be more receptive to vaccinating their daughters against Human Papillomavirus (HPV), while white, middle-class parents are more likely to defer the vaccination. The findings appear online in the May issue of the Journal of Health Care for the Poor and Underserved. Cervical cancer incidence and mortality are markedly higher for low-income and minority women due to higher rates of HPV and limited access to screening and treatment... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Cervical Cancer / HPV Vaccine Source Type: news

Knowledge of human papillomavirus and cervical cancer among young women recruited using a social networking site
Conclusions HPV and cervical cancer knowledge among participants were relatively high compared with other studies conducted both worldwide and in Australia. However, deficits in knowledge exist and warrant address in educational initiatives. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - May 17, 2013 Category: Sexual Medicine Authors: Gunasekaran, B., Jayasinghe, Y., Fenner, Y., Moore, E. E., Wark, J. D., Fletcher, A., Tabrizi, S. N., Garland, S. M. Tags: Epidemiologic studies, Drugs: infectious diseases, Vaccination / immunisation, Cervical cancer, Gynecological cancer, Vulvovaginal disorders Epidemiology Source Type: research

CD14 Enhances Immune Activation by Curli [Microbiology]
Amyloids, protein aggregates with a cross β-sheet structure, contribute to inflammation in debilitating disorders, including Alzheimer's disease. Enteric bacteria also produce amyloids, termed curli, contributing to inflammation during infection. It has been demonstrated that curli and β-amyloid are recognized by the immune system via the Toll-like receptor (TLR) 2/TLR1 complex. Here we investigated the role of CD14 in the immune recognition of bacterial amyloids. We used HeLa 57A cells, a human cervical cancer cell line containing a luciferase reporter gene under the control of an NF-κB promoter. When HeLa 57A cells we...
Source: Journal of Biological Chemistry - May 17, 2013 Category: Chemistry Authors: Rapsinski, G. J., Newman, T. N., Oppong, G. O., van Putten, J. P. M., Tukel, C. Tags: Immunology Source Type: research

Detection of high risk human papillomavirus by hybrid capture II(r) according cytological findings in women treated for squamous intraepithelial lesions of the cervix, period 2006/2010
CONCLUSION: La detección de HR-HPV por CH II(r), así como los valores de carga viral relativa altos, en especial en mujeres con NSIL podrían ayudar a identificar mujeres tratadas con riesgo a desarrollar recidivas, contribuyendo así a fortalecer el programa de prevención de cáncer de cuello uterino. OBJECTIVE: To determinate the frequency of high risk human papillomavirus (HR-HPV) by hybrid capture II (r) (CH II(r)), according cytology results in women treated for squamous intraepithelial lesions of the cervix (SIL). MATERIAL AND METHODS: A descriptive cross-sectional study ...
Source: Revista Brasileira de Epidemiologia - May 16, 2013 Category: Epidemiology Source Type: research

Patient Barriers to Follow-Up Care for Breast and Cervical Cancer Abnormalities
Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)
Source: Journal of Women - May 14, 2013 Category: OBGYN Tags: article Source Type: research

Methylation‐Specific Digital Karyotyping of HPV16E6E7 expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis
In conclusion, MSDK analysis of HPV16 transduced keratinocytes at different stages of HPV‐induced transformation resulted in the identification of novel DNA methylation events, involving FAM19A4, LHX1, NKX2‐8, PHACTR3, and PRDM14 genres, in cervical carcinogenesis. These genes may provide promising triage markers to assess the presence of (pre)cancerous cervical lesions in hrHPV‐positive women. (Source: The Journal of Pathology)
Source: The Journal of Pathology - May 14, 2013 Category: Pathology Authors: Renske D.M. Steenbergen, Maté Ongenaert, Suzanne Snellenberg, Geert Trooskens, Wendy F. van der Meide, Deeksha Pandey, Noga Bloushtain‐Qimron, Kornelia Polyak, Chris J.L.M. Meijer, Peter J.F. Snijders, Wim Van Criekinge Tags: Research Article Source Type: research

Diffusion of Preventive Innovation: Racial and Rural Differences in Cervical Cancer Prevention and Control Practices (Key Facts)
Examines differences in receipt of cervical cancer screening and HPV vaccination associated with residence and race/ethnicity. -- South Carolina Rural Health Research Center (Source: Rural publications via the Rural Assistance Center)
Source: Rural publications via the Rural Assistance Center - May 13, 2013 Category: Rural Health Source Type: news

Diffusion of Preventive Innovation: Racial and Rural Differences in Cervical Cancer Prevention and Control Practices (Full Report)
Examines differences in receipt of cervical cancer screening and HPV vaccination associated with residence and race/ethnicity. -- South Carolina Rural Health Research Center (Source: Rural publications via the Rural Assistance Center)
Source: Rural publications via the Rural Assistance Center - May 13, 2013 Category: Rural Health Source Type: news

Volumetric MR images boost cervical cancer treatment planning
Three-dimensional volumetric MR images of cervical disease yield a bounty of (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - May 13, 2013 Category: Radiology Source Type: news

Methods to increase participation in organised screening programs: a systematic review
Conclusion: Although some interventions did prove to be effective, some specific variables may influence their effectiveness in and applicability to organised population-based screening programs. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - May 13, 2013 Category: Consumer Health News Authors: Laura CamilloniEliana FerroniBeatriz CendalesAnnamaria PezzarossiGiacomo FurnariPiero BorgiaGabriella GuasticchiPaolo Rossi Source Type: research

Ficusonic acid: a new cytotoxic triterpene isolated from Maytenus royleanus (Wall. ex M. A. Lawson) cufodontis
Phytochemical investigation of the roots of Maytenus royleanus resulted into the isolation of a new cytotoxic triterpene ficusonic acid, 3β,21β-dihydroxyolean-12-en-29-oic acid, together with three known compounds, 3α,22β-dihydroxyolean-12-en-29-oic acid, salaspermic acid and orthosphenic acid, reported for the first time from this source. Their structures were established on the basis of extensive spectroscopic techniques. The cytotoxic activity of compound 3β,21β-dihydroxyolean-12-en-29-oic acid was evaluated against two cancer cell lines, PC-3 prostate and HeLa cervical cancer lines. 3β,21β-dihydroxyolean-12-en-...
Source: Journal of the Brazilian Chemical Society - May 12, 2013 Category: Chemistry Source Type: research

Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.
Abstract Previously, we found that two isoforms of the ZNF268 gene (ZNF268a and ZNF268b2, with and without the KRAB domain, respectively) might play distinct roles in normal epithelia and in cervical cancer. Here we further investigated that KRAB domain defined the function disparity in part by reinforcing nuclear localization of ZNF268a. We found that the A-box of KRAB alone retained major specific nuclear localization activity. In contrast, the B-box alone did not have nuclear localization activity but enhanced it significantly. Consistent with the critical function of the A-box, each mutation of six conserved re...
Source: Cellular and Molecular Life Sciences : CMLS - May 12, 2013 Category: Cytology Authors: Wang W, Cai J, Wu Y, Hu L, Chen Z, Hu J, Chen Z, Li W, Guo M, Huang Z Tags: Cell Mol Life Sci Source Type: research

College Sorority Members’ Knowledge and Behaviors Regarding Human Papillomavirus and Cervical Cancer
This study describes female college students’ knowledge regarding HPV and cervical cancer, identifies sexual risk behaviors in this group, and assesses whether there is any relationship between knowledge of HPV and cervical cancer and the sexual risk behaviors in this population. Health care providers need to be aware of this health issue and actively promote appropriate prevention strategies. (Source: Nursing Clinics of North America)
Source: Nursing Clinics of North America - May 10, 2013 Category: Nursing Authors: Mollie E. Aleshire, Sharon E. Lock, Lynne A. Jensen Source Type: research

Africa: HPV Vaccine Deals to Protect Millions Against Cervical Cancer
[GAVI]Historic agreements show power of innovative public-private partnership (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 10, 2013 Category: African Health Source Type: news

Sikkim to go slow on multimillion cervical cancer vaccine project
The state has decided to go slow on it putting the already troubled multimillion vaccine deal further deep under uncertainty. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - May 10, 2013 Category: Pharmaceuticals Source Type: news

GSK, Merck Cut Price Of HPV Vaccine In Poor Countries
A new all-time low price for human papillomavirus (HPV) vaccines will now help guarantee that millions of girls in poor countries are protected against cervical cancer. This will be made possible by the GAVI alliance (the Global Alliance for Vaccines and Immunization) - a public-private partnership that aims to save children's lives by funding vaccines in the world's 70 poorest nations. Now, these countries will have access to a large supply of HPV vaccines for a low as US $4.50 per dose. These same vaccines are often sold for more than $100 in developed countries... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Cervical Cancer / HPV Vaccine Source Type: news

Bowen disease of the palm associated with human papillomavirus 52
We report a case of BD of the palm, which is a very rare location for BD. In addition to its rare location, HPV52, which is classified as a mucous high‐risk HPV type, was detected in the lesion by PCR restriction fragment length polymorphism analysis. To our knowledge, this is the first reported case of BD associated with HPV52. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - May 10, 2013 Category: Dermatology Authors: K. Murao, M. Tetsutani, T. Ishigami, Y. Kubo, S. Arase Tags: Clinical dermatology • Source Type: research

GSK enters new commitment with the GAVI Alliance to supply cervical cancer vaccine for girls in the world’s poorest countries
GlaxoSmithKline (GSK) today announced a new commitment to the GAVI Alliance to supply its cervical cancer vaccine as part of a new long term programme to help protect girls against cervical cancer in the world’s poorest countries. (Source: GSK news)
Source: GSK news - May 9, 2013 Category: Pharmaceuticals Source Type: news

Merck, GSK cut price of cervical cancer shots for poor countries
LONDON (Reuters) - Drugmakers Merck and GlaxoSmithKline have cut the price of cervical cancer shots in a deal that will deliver them to poor countries for less than $5 a dose. (Source: Reuters: Health)
Source: Reuters: Health - May 9, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Prices Cut for HPV Cervical Cancer Vaccines for Neediest
Two drug companies will charge less than $5 a dose to expand protection from the virus known as HPV to millions of girls in the poorest countries. (Source: NYT Health)
Source: NYT Health - May 9, 2013 Category: Consumer Health News Authors: By DONALD G. McNEIL Jr. Tags: GAVI Alliance Human Papilloma Virus (HPV) Cervical Cancer Cervarix (Vaccine) Merck & Company Inc MRK NYSE GlaxoSmithKline PLC GSK NYSE Gardasil (Vaccine) Vaccination and Immunization Source Type: news

Individual and geographic disparities in human papillomavirus types 16/18 in high‐grade cervical lesions
CONCLUSIONSBlack race, Hispanic ethnicity, and higher area‐based poverty are salient predictors of lower HPV 16/18 positivity among women with high‐grade cervical lesions. These data suggest that HPV vaccines might have lower impact among black and Hispanic women and those living in high poverty areas. These findings have implications for vaccine impact monitoring, vaccination programs, and new vaccine development. Cancer 2013; © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - May 9, 2013 Category: Cancer & Oncology Authors: Linda M. Niccolai, Chelsea Russ, Pamela J. Julian, Susan Hariri, John Sinard, James I. Meek, Vanessa McBride, Lauri E. Markowitz, Elizabeth R. Unger, James L. Hadler, Lynn E. Sosa Tags: Original Article Source Type: research

Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia
Abstract The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real‐time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a preca...
Source: Clinical Microbiology and Infection - May 9, 2013 Category: Microbiology Authors: A. Gradíssimo Oliveira, C. Delgado, N. Verdasca, Â. Pista Tags: Research Note Source Type: research

HIV-infected Women Have Higher Risk of Incident Invasive Cervical Cancer
Key points for primary care physicians from a new study: HIV-positive women are vulnerable to invasive cervical cancer. This finding underscores the need for screening per guidelines and to follow-up on abnormal pap smears. (Source: Consultant Live)
Source: Consultant Live - May 8, 2013 Category: Primary Care Source Type: news

Researchers discover possible trigger for spread of head and neck cancer cells
UCLA RESEARCH ALERT FINDINGS: Very little has been known about the epigenetic events — developmental and environmental factors affecting genes — that occur prior to the invasive growth of head and neck squamous cell carcinomas and their spread to other parts of the body, or metastasis. However, researchers from the UCLA School of Dentistry discovered what could be a crucial step toward understanding the process that activates the cancer cells. Squamous cell carcinoma is known for being one of the most deadly and debilitating types of tumors. Led by Dr. Cun-Yu Wang, a UCLA School of Dentistry profe...
Source: UCLA Newsroom: Health Sciences - May 7, 2013 Category: Universities & Medical Training Source Type: news

'I'm going to give birth to my grandchild': Grandmother, 49, offers to be surrogate for her 27-year-old cancer survivor daughter
Linda Donaghey, 49, offered to be a surrogate for her daughter Sarah, 27, from Leeds, after she lost her womb to cervical cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - May 7, 2013 Category: Consumer Health News Source Type: news

Expression of HPV16 E5 down-modulates the TGFbeta signaling pathway
Conclusions: Taken together our results indicate that HPV16 E5 expression is able to attenuate the TGFbeta1/Smad signaling and propose that this loss of signal transduction, leading to destabilization of the epithelial homeostasis at very early stages of viral infection, may represent a crucial mechanism of promotion of the HPV-mediated cervical carcinogenesis. (Source: Molecular Cancer)
Source: Molecular Cancer - May 7, 2013 Category: Cancer & Oncology Authors: Deborah FrenchFrancesca BelleudiMaria Vittoria MauroFrancesca MazzettaSalvatore RaffaVincenza FabianoAntonio FregaMaria Rosaria Torrisi Source Type: research

Chemoradiation With Paclitaxel and Carboplatin in High-Risk Cervical Cancer Patients After Radical Hysterectomy: A Korean Gynecologic Oncology Group Study
Conclusions: Concurrent chemoradiation with paclitaxel/carboplatin is well tolerated and seems to be effective for patients who undergo radical hysterectomy. Therefore, a prospective, randomized controlled study should be designed to evaluate efficacy of this approach for patients with high-risk cervical cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 6, 2013 Category: Radiology Authors: Taek Sang Lee, Soon Beom Kang, Young Tak Kim, Byung Joo Park, Yong Man Kim, Jong Min Lee, Seok Mo Kim, Young Tae Kim, Jae Hoon Kim, Kyung Tai Kim Tags: Gynecologic Cancer Source Type: research

Issue Highlights
Mundt et al In this edition's Oncology Scan, each of the 4 gynecology associate editors have selected and reviewed a noteworthy article from the general gynecologic cancer literature. The first is a study comparing different volumetric imaging modalities used for brachytherapy treatment planning in cervical cancer patients and the second one looks at the distribution of aortocaval lymph nodes in similar patients based on molecular imaging. A meta-analysis of adjuvant radiation therapy in early stage endometrial cancer presented by the Cochrane Gynaecological Cancer Review Group is also discussed, as well as an outcome st...
Source: International Journal of Radiation Oncology * Biology * Physics - May 6, 2013 Category: Radiology Source Type: research

Cervical Cancer Detection In Kenya Via Self-Collection Of Samples For HPV Testing
In Kenya, women face a cervical cancer mortality rate that is approximately 10 times as high as in the United States. A study by researchers at the University of North Carolina at Chapel Hill suggests that training women to self-collect genital samples to test for human papillomavirus (HPV), the causative agent of cervical cancer, can increase the coverage rates of cervical cancer screening. Higher screening coverage helps increase rates of detection of cervical lesions and ultimately treatment of the disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 6, 2013 Category: Consumer Health News Tags: Cervical Cancer / HPV Vaccine Source Type: news

STD's Not Cancer Prevention Should Be The Focus For Promoting HPV Vaccine
The HPV vaccine can prevent both cervical cancer and a nasty sexually transmitted disease in women. But emphasizing the STD prevention will persuade more young women to get the vaccine, a new study suggests. These results go against the conventional wisdom that scaring women about the possibility of cancer is the best way to get them vaccinated... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 6, 2013 Category: Consumer Health News Tags: Cervical Cancer / HPV Vaccine Source Type: news

Understanding cervical cancer screening among lesbians: a national survey
Conclusions: Some women who identify as lesbian are at potentially elevated risk of cervical cancer because they are not routinely screened. Evidence-based interventions should be developed that address critical health beliefs that undermine participation in screening. Given the value placed on physician recommendation, patient-provider communication may serve as the optimal mode for intervention delivery. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - May 4, 2013 Category: Consumer Health News Authors: J TracyNicholas SchlutermanDeborah Greenberg Source Type: research

HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia
Conclusions: HPV prevalence (82%) in cervical cancer is at the lower range of the worldwide estimation (85 - 99%). While XRCC1 G399A was significantly associated with cervical cancer, TP53 G72C showed borderline association only in HPV-positive patients. Deviation from HWE in HPV-positive patients indicates co-selection, hence implicating the combination of HPV and SNPs in cancer predisposition. Thus, SNPs could be more relevant biomarkers of susceptibility to cervical cancer when associated with HPV infection. (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - May 4, 2013 Category: Cancer & Oncology Authors: Ghazi AlsbeihNajla Al-HarbiMedhat El-SebaieIsmail Al-Badawi Source Type: research

Factors associated with cervical cancer screening uptake among Inuit women in Nunavik, Quebec, Canada
Conclusions: Our results suggest that older women and women who are not accessing reproductive care have a lower compliance with time-appropriate cervical cancer screening and future research should address potential strategies to increase screening coverage among this group. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - May 3, 2013 Category: Consumer Health News Authors: Helen CerigoFrancois CoutléeEduardo FrancoPaul Brassard Source Type: research

The Hysterectomy Association May Newsletter 2013
Welcome to the May 2013 newsletter and it finally feels as if Spring has arrived, in fact I’m loving the fact that we have blue skies and some warm weather beating down on us finally. The only downside is that it does mean staying indoors to work when I’d rather be outdoors enjoying myself. Hopefully it will be good at the weekend too. Hysteria Short Story Writing Competition 2013 The 1st April saw the launch of this years short story writing competition for women only. The winner of last years competition was Jane Thickett with her story ‘Banana Loaf: A recipe for solace; and you can find her story and ...
Source: The Hysterectomy Association - May 2, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Latest News Newsletters clinical trial covance hysteria 1 hysteria 2013 writing competition in my own owns: women's experiences of hysterectomy kickstarter Source Type: news