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This page shows you the latest news and research items in this category.

Effect of belly board with bladder compression device on small bowel displacement from the radiotherapy field for rectal cancer.
Conclusion: This study showed that the addition of a BCD to the BB could effectively provide further displacement of SB from the rectal cancer radiotherapy field. PMID: 23689217 [PubMed - in process] (Source: Onkologie)
Source: Onkologie - May 24, 2013 Category: Cancer & Oncology Authors: Chung Y, Yoon HI, Keum KC, Kim JH, Choi WH, Nam KC, Koom WS Tags: Onkologie Source Type: research

Prediction of recurrence in low and intermediate risk non-muscle invasive bladder cancer by real-time quantitative PCR analysis: cDNA microarray results.
Abstract The aim of the study was to define specific genetic profile in Ta and T1 urinary bladder carcinoma patients with and without recurrence by gene expression microarrays. Eleven patients with the time to recurrence shorter than one year (patients with recurrence) and 11 patients with time to recurrence longer than 4 years (patients without recurrence) were enrolled. Data from microarrays were subjected to a panel of statistical analyses to identify bladder cancer recurrence-associated gene signatures. Initial screening using the GeneSpring and Bioconductor software tools revealed a putative set 47 genes diffe...
Source: Neoplasma - May 24, 2013 Category: Cancer & Oncology Authors: Mares J, Szakacsova M, Soukup V, Duskova J, Horinek A, Babjuk M Tags: Neoplasma Source Type: research

Egg consumption and risk of bladder cancer: a meta-analysis.
In conclusion, our findings suggest no significant association between egg consumption and bladder cancer risk, except for a possible positive relationship with the intake of fried eggs based on the limited number of studies. Additional studies, especially large prospective cohort studies, are warranted to confirm these findings. PMID: 23659445 [PubMed - in process] (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - May 24, 2013 Category: Cancer & Oncology Authors: Li F, Zhou Y, Hu RT, Hou LN, Du YJ, Zhang XJ, Olkkonen VM, Tan WL Tags: Nutr Cancer Source Type: research

Inexpensive, Accurate Way To Detect Prostate Cancer Could Facilitate Commercially Available, At-Home Urine Tests
Early screening for prostate cancer could become as easy for men as personal pregnancy testing is for women, thanks to UC Irvine research published in the /iJournal of the American Chemical Society. After more than a decade of work, UC Irvine chemists have created a way to clearly identify clinically usable markers for prostate cancer in urine, meaning that the disease could be detected far sooner, with greater accuracy and at dramatically lower cost. The same technology could potentially be used for bladder and multiple myeloma cancers, which also shed identifiable markers in urine... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 24, 2013 Category: Consumer Health News Tags: Prostate / Prostate Cancer Source Type: news

The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism.
In this report, we identified the role of PEITC on ADM resistance reversal of human bladder carcinoma T24/ADM cells, including an increased drug sensitivity to ADM, cell apoptosis rates, intracellular accumulation of Rhodamine-123 (Rh-123), an increased expression of DNA topoisomerase II (Topo-II), and a decreased expression of multidrug resistance gene (MDR1), multidrug resistance-associated protein (MRP1), bcl-2 and glutathione s transferase π (GST-π).We also found that there was a decreased expression of NF-κB, Survivin, Twist, and p-Akt, and an increased expression of PTEN and p-JNK after PEITC treatment for T24/ AD...
Source: Anatomical Record - May 24, 2013 Category: Anatomy Authors: Tang K, Lin Y, Li LM Tags: Anat Rec (Hoboken) Source Type: research

Understanding Stress Incontinence
Stress incontinence is one of the most common forms of incontinence and it’s estimated that three million people in the UK are affected although this number may be conservative because some won’t mention it to their doctors. It also becomes more common in women as they age and go through the menopause. Estimates suggest that 1 in 5 women over 40 may suffer some degree of stress incontinence. As we eat and drink the kidneys produce urine which passes through the ureter tubes to the bladder. The amount we eat and drink influences the amount of urine that is made. As the bladder fills with urine it swells until we feel a ...
Source: The Hysterectomy Association - May 23, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Latest News Videos Women's Health incontinence kegel exercises pelvic floor exercises pelvic floor muscles stress incontinence Source Type: news

Monitor unit optimization in RapidArc plans for prostate cancer.
Abstract Intensity-modulated radiation therapy (IMRT) has become a standard treatment for prostate cancer based on the superior sparing of the bladder, rectum, and other surrounding normal tissues compared to three-dimensional conformal radiotherapy, despite the longer delivery time and the increased number of monitor units (MU). The novel RapidArc technique represents a further step forward because of the lower number of MUs per fraction and the shorter delivery time, compared to IMRT. This paper refers to MU optimization in RA plans for prostate cancer, using a tool incorporated in Varian TPS Eclipse. The goal wa...
Source: Journal of Applied Clinical Medical Physics - May 23, 2013 Category: Physics Authors: Clemente S, Cozzolino M, Chiumento C, Fiorentino A, Caivano R, Fusco V Tags: J Appl Clin Med Phys Source Type: research

Local tumor control probability to evaluate an applicator-guided volumetric-modulated arc therapy solution as alternative of 3D brachytherapy for the treatment of the vaginal vault in patients affected by gynecological cancer.
Abstract The purpose of this study was to evaluate the applicator-guided volumetric-modulated arc therapy (AGVMAT) solution as an alternative to high-dose-rate brachytherapy (HDR-BRT) treatment of the vaginal vault in patients with gynecological cancer (GC). AGVMAT plans for 51 women were developed. The volumetric scans used for plans were obtained with an implanted CT-compatible vaginal cylinder which provides spatial registration and immobilization of the gynecologic organs. Dosimetric and radiobiological comparisons for planning target volume (PTV) and organs at risk (OARs) were performed by means of a dose-volu...
Source: Journal of Applied Clinical Medical Physics - May 23, 2013 Category: Physics Authors: Pedicini P, Strigari L, Caivano R, Fiorentino A, Califano G, Nappi A, Improta G, Storto G, Cozzolino M, Chiumento C, Fusco V, Vavassori A, Benassi M, Orecchia R, Salvatore M Tags: J Appl Clin Med Phys Source Type: research

Snapshot of Transurethral resection of bladder tumours in the United Kingdom Audit (STUKA)
ConclusionThe quality of TURBT in the UK is high. Areas for improvement include the timeliness of diagnosis and treatment, and improved care of patients with intermediate risk NMIBC and MIBC. The snapshot methodology is promising but widening participation is a priority. (Source: BJU International)
Source: BJU International - May 20, 2013 Category: Urology & Nephrology Authors: Christine Gan, Amit Patel, Sarah Fowler, James Catto, Derek Rosario, Timothy O′Brien Tags: Original Article Source Type: research

Hypermethylation of TWIST1 and NID2 in Tumor Tissues and Voided Urine in Urinary Bladder Cancer Patients
DNA and Cell Biology , Vol. 0, No. 0. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - May 19, 2013 Category: Cytology Tags: article Source Type: research

Using microRNA profiling in urine samples to develop a non‐invasive test for bladder cancer
This study aimed to examine the microRNA (miRNA) expression profiles in urines of UCC patients in order to develop a non‐invasive accurate and reliable tool to diagnose and provide information on the aggressiveness of the tumour. We performed a global miRNA expression profiling analysis of the urinary cells from 40 UCC patients and controls using TaqMan® Human MicroRNA Array followed by validation of 22 selected potentially diagnostic and prognostic miRNAs in a separate cohort of 277 samples using a miRCURY LNATM qPCR system. miRNA‐based signatures were developed by multivariate logistic regression analysis and intern...
Source: International Journal of Cancer - May 19, 2013 Category: Cancer & Oncology Authors: Lourdes Mengual, Juan José Lozano, Mercedes Ingelmo‐Torres, Cristina Gazquez, María José Ribal, Antonio Alcaraz Tags: Early Detection and Diagnosis Source Type: research

Republished: Non-invasive urine based tests for the detection of bladder cancer
This article reports some of the more prominent urine markers and new technologies used nowadays. (Source: Postgraduate Medical Journal)
Source: Postgraduate Medical Journal - May 17, 2013 Category: Journals (General) Authors: Wadhwa, N., Jatawa, S. K., Tiwari, A. Tags: Urology, Urological cancer, Screening (oncology) Republished review Source Type: research

The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent.
Abstract Activation of Toll-like receptor 4 (TLR4) triggers both innate and adaptive immunity. We previously identified a synthetic glycolipid, CCL-34, which can induce anticancer immunity in a TLR4-dependent manner. In the present study, we demonstrated the involvement of THO complex 1 (thoc1) in the CCL-34-induced anticancer mechanism. The expression of thoc1 was suppressed in bladder cancer cells (MBT-2) co-cultured with CCL-34-activated macrophages, whereas treatment with an iNOS inhibitor could restore the expression of thoc1. Direct treatment of MBT-2 cells with an NO donor also repressed thoc1 expression. Im...
Source: Biochemical Pharmacology - May 17, 2013 Category: Drugs & Pharmacology Authors: Lin YS, Lin CH, Huang LD, Chao T, Kuo CD, Hung LC, Wong FH, Lin CC, Fu SL Tags: Biochem Pharmacol Source Type: research

Impact of behaviour and lifestyle on bladder health
Bladder conditions, including UTI, UI, and bladder cancer, are highly prevalent and affect a wide range of populations. There are a variety of modifiable behavioral and lifestyle factors that influence bladder health. Some factors, such as smoking and obesity, increase the risk or severity of bladder conditions, whereas other factors, such as pelvic floor muscle exercise, are protective. Although clinical practice may be assumed to be the most appropriate ground for education on behavioral and lifestyle factors that influence bladder health, it is also crucial to extend these messages into the general population through pu...
Source: International Journal of Clinical Practice - May 16, 2013 Category: Internal Medicine Authors: K. L. Burgio, D. K. Newman, M. T. Rosenberg, C. Sampselle Tags: Perspective Source Type: research

Diabetes Drug Actos Caused Bladder Cancer and Wrongful Death of Ohio...
Parker Waichman LLP has filed a lawsuit alleging that Actos (pioglitazone) caused bladder cancer and the subsequent wrongful death of an Ohio man. Actos is a drug used to treat Type 2 diabetes; the...(PRWeb May 14, 2013)Read the full story at http://www.prweb.com/releases/actos-attorneys/052013/prweb10732524.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 15, 2013 Category: Pharmaceuticals Source Type: news

New Lawsuit on Actos Bladder Cancer: Now, AttorneyOne Can Provide...
According to court documents, on May 9, 2013, two men filed a lawsuit in North Dakota District Court alleging they suffer from bladder cancer caused by Actos. In light of this news, AttorneyOne, a...(PRWeb May 13, 2013)Read the full story at http://www.prweb.com/releases/2013/5/prweb10724565.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 15, 2013 Category: Pharmaceuticals Source Type: news

Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization.
CONCLUSION: eIF3b expression relates to human bladder and prostate cancer prognosis, is required for tumor growth, and thus a candidate therapeutic target. Clin Cancer Res; 19(11); 1-11. ©2013 AACR. PMID: 23575475 [PubMed - as supplied by publisher] (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - May 15, 2013 Category: Cancer & Oncology Authors: Wang H, Ru Y, Sanchez-Carbayo M, Wang X, Kieft JS, Theodorescu D Tags: Clin Cancer Res Source Type: research

Fish in the diet: A review
Summary Fish plays a useful role in a healthy and balanced diet, and its consumption has long been associated with several health benefits. Fish provides a variety of nutrients, including protein and long‐chain omega‐3 polyunsaturated fatty acids (n‐3 PUFAs), as well as micronutrients including selenium, iodine, potassium, vitamin D and B‐vitamins. Intakes of some of these micronutrients, including iodine and vitamin D, are low in some population groups in the UK, which makes fish a valuable contributor to intakes of these. The long‐chain n‐3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), pres...
Source: Nutrition Bulletin - May 15, 2013 Category: Nutrition Authors: E. Weichselbaum, S. Coe, J. Buttriss, S. Stanner Tags: REVIEW Source Type: research

Overall survival advantage with partial nephrectomy: A bias of observational data?
CONCLUSIONSRN patients had similar OS compared with controls, suggesting that this treatment modality does not compromise survival. Patients undergoing PN had improved OS compared with controls, suggesting possible selection bias. The apparent survival advantage conferred by PN in SEER‐Medicare case series is likely the result of selection bias involving unmeasured confounders. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - May 14, 2013 Category: Cancer & Oncology Authors: Brian Shuch, Janet Hanley, Julie Lai, Srinivas Vourganti, Simon Kim, Claude M. Setodji, Andrew W. Dick, Wong‐Ho Chow, Chris Saigal, Tags: Original Article Source Type: research

Urinary high molecular weight matrix metalloproteinases as non-invasive biomarker for detection of bladder cancer
Conclusions: This study revealed that the detection of urinary MMPs including HMWs activity might be sensitive biomarkers for prediction of bladder cancer. It is also demonstrate that the detection of these urinary HMW gelatinases could not differentiate between bilharzial and non bilharzial bladder cancer subtypes. (Source: BMC Urology - Latest articles)
Source: BMC Urology - Latest articles - May 14, 2013 Category: Urology & Nephrology Authors: Mohammed MohammedManar SeleimMohga AbdallaHayat SharadaAbdel Abdel Wahab Source Type: research

Does age really matter in the choice of treatment for bladder cancer?
Does age really matter in the choice of treatment for bladder cancer? British Journal of Cancer advance online publication, May 14 2013. doi:10.1038/bjc.2013.239 Authors: F Dal Moro, A Rossi & F Zattoni (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - May 14, 2013 Category: Cancer & Oncology Authors: F Dal MoroA RossiF Zattoni Source Type: research

Copy number aberrations by multi‐color fluorescence in situ hybridization predict prognosis in non‐muscle‐invasive bladder cancer
ConclusionsA multicolor‐FISH analysis using commercially available kit could be a powerful molecular marker not only for diagnosis, but also for predicting patient prognosis in patients with NMIBC. (Source: BJU International)
Source: BJU International - May 14, 2013 Category: Urology & Nephrology Authors: Hideyasu Matsuyama, Kenzo Ikemoto, Satoshi Eguchi, Atsunori Oga, Shigeto Kawauchi, Yoshiaki Yamamoto, Yoshihisa Kawai, Hiroaki Matsumoto, Takahiko Hara, Kazuhiro Nagao, Shigeru Sakano, Kohsuke Sasaki Tags: Original Article Source Type: research

Genetic polymorphisms in the matrix metalloproteinases, tissue inhibitors of metalloproteinases and bladder cancer susceptibility
ConclusionsOur results suggest that genetic variations in five polymorphisms of MMPs and TIMPs are not associated with a high risk of BC. Only MMP1 polymorphism may be related to the risk of BC, notably in ever‐smokers. Our study suggests that the effects of polymorphisms of MMPs and TIMPs on BC risk deserve further investigation. (Source: BJU International)
Source: BJU International - May 14, 2013 Category: Urology & Nephrology Authors: Edyta Wieczorek, Edyta Reszka, Zbigniew Jablonowski, Ewa Jablonska, Magdalena Beata Krol, Adam Grzegorczyk, Jolanta Gromadzinska, Marek Sosnowski, Wojciech Wasowicz Tags: Original Article Source Type: research

Study Claims Marijuana Tied to Lower Bladder Cancer Risk
Title: Study Claims Marijuana Tied to Lower Bladder Cancer RiskCategory: Health NewsCreated: 5/10/2013 6:35:00 PMLast Editorial Review: 5/13/2013 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - May 13, 2013 Category: Cancer & Oncology Source Type: news

Single‐port transvesical laparoscopic radical prostatectomy for organ‐confined prostate cancer: technique and outcomes
Laparoscopic radical prostatectomy (LRP) has become a standard approach in the treatment of organ‐confined prostate cancer. However, postoperative incontinence and loss of sexual function have significant adverse effects on quality of life. Although some modifications, including preservation of the bladder neck [1], sparing neurovascular bundles and apical modified dissection [2], have been implemented to improve the outcomes of postoperative continence and sexual function, achieving the rapid recovery of continence and sexual function remains a huge challenge. Recently, Wilt et al reported that radical prostatectomy did...
Source: BJU International - May 11, 2013 Category: Urology & Nephrology Authors: Xin Gao, Jun Pang, Jie Si‐tu, Yun Luo, Hao Zhang, Liao‐yuan Li, Yan Zhang Tags: Robotics and Laparoscopy Source Type: research

Study Claims Marijuana Tied to Lower Bladder Cancer Risk
But experts question the study's design and are skeptical of the conclusion (Source: Fertility News - Doctors Lounge)
Source: Fertility News - Doctors Lounge - May 11, 2013 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Oncology, Reproductive Medicine, Research, Dependence, News, Source Type: news

Marijuana May Lower Bladder Cancer RiskMarijuana May Lower Bladder Cancer Risk
A new study shows that smoking marijuana might decrease the smoker's risk for bladder cancer. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 10, 2013 Category: Consumer Health News Tags: Urology News Source Type: news

Bladder Cancer Could Reoccur Despite Bladder Removal
Patients with advanced bladder cancers that are surgically removed might need additional therapy to prevent recurrence in certain situations, a new UT Southwestern Medical Center study suggests. The five-year international study led by researchers at UT Southwestern validates the use of a marker panel to predict which patients are more likely to have a recurrence of cancer after bladder removal, thereby identifying those patients as good candidates for follow-up chemotherapy... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Kidney Stones Prove Occupational Hazard for Surgeons, Mayo Clinic Study Finds
Mayo Clinic urologists presented studies on kidney stone incidence in surgical teams, blood clot risk and survival following bladder cancer surgery, genomic testing for metastatic prostate cancer and other research at the American Urological Association's annual meeting. (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 9, 2013 Category: Databases & Libraries Authors: Mayo Clinic Source Type: news

Kidney Stones Prove Occupational Hazard for Surgeons, Mayo Clinic Study Finds
Mayo Clinic urologists presented studies on kidney stone incidence in surgical teams, blood clot risk and survival following bladder cancer surgery, genomic testing for metastatic prostate cancer and other research at the American Urological Association's annual meeting. (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 9, 2013 Category: Research Authors: Mayo Clinic Source Type: news

Kidney Stones Prove Occupational Hazard for Surgeons, Mayo Clinic Study Finds
Mayo Clinic urologists presented studies on kidney stone incidence in surgical teams, blood clot risk and survival following bladder cancer surgery, genomic testing for metastatic prostate cancer and other research at the American Urological Association's annual meeting. (Source: Mayo Clinic Rochester News)
Source: Mayo Clinic Rochester News - May 9, 2013 Category: Hospital Management Authors: Mayo Clinic Source Type: news

Bladder Cancer Deserves Urgent Attention
It is the 4th most common cancer in men[1] (and 11th in women), but bladder cancer remains an extremely low priority in the UK. Action on Bladder Cancer[2] (ABC) reports that almost half (45%) of the UK public do not know that even just one episode of blood in the urine, the most common warning sign, could mean bladder cancer. Smoking is the most common cause of bladder cancer and yet 95% of people are not aware of this. ABC calls for much stronger recognition of bladder cancer amongst the general public and the medical profession in order to prevent avoidable deaths... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 9, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Outpatient Laser Ablation of Non‐Muscle Invasive Bladder Cancer; is it Safe, Tolerable and Cost‐Effective?
ConclusionsThis first report on the safety and tolerability of outpatient laser ablation of NMIBC and the feasibility of PDD as an adjunct The first study to demonstrate the long term cost‐effectiveness of OLA of NMIBC Results support the use of OLA for the treatment of NMIBC especially in the elderly (Source: BJU International)
Source: BJU International - May 9, 2013 Category: Urology & Nephrology Authors: Kathie A Wong, Grace Zisengwe, Thanos Athanasiou, Tim O′Brien, Kay Thomas Tags: Urological Oncology Source Type: research

Unaltered Oncologic Outcomes of Radical Cystectomy with Extended Lymphadenectomy Over Three Decades
ConclusionsRadical surgery remains the mainstay of therapy for muscle‐invasive bladder cancer Yet, our study reveals predictable outcomes but no survival improvement in patients undergoing RC over the last three decades Any future survival improvements are likely to result from more effective systemic treatments and/or earlier detection of the disease (Source: BJU International)
Source: BJU International - May 9, 2013 Category: Urology & Nephrology Authors: Pascal Zehnder, Urs E. Studer, Eila C. Skinner, George N. Thalmann, Gus Miranda, Beat Roth, Jie Cai, Frédéric D. Birkhäuser, Anirban P. Mitra, Fiona C. Burkhard, Ryan P. Dorin, Siamak Daneshmand, Donald G Skinner, Inderbir S. Gill Tags: Urological Oncology Source Type: research

Study: Bladder cancer could reoccur despite bladder removal
Patients with advanced bladder cancers that are surgically removed might need additional therapy to prevent recurrence in certain situations, a new study suggests. (Source: UT Southwestern Medical Center News)
Source: UT Southwestern Medical Center News - May 8, 2013 Category: Hospital Management Source Type: news

The natural history of secondary muscle-invasive bladder cancer
Conclusion: In the current series, MIBC progression occurred among initially presenting patients with NMIBC in 6.1%. In most patients, the initial diagnosis of NMIBC is correct and muscle invasion occurs after a mean period of about 2 years. This supports a non-radical approach in patients with high-grade T1, Ta or Tis. Meticulous follow-up with liberal biopsy of any suspicious lesion may provide early diagnosis of invasive disease. (Source: BMC Urology - Latest articles)
Source: BMC Urology - Latest articles - May 8, 2013 Category: Urology & Nephrology Authors: Guy HidasDov PodeAmos ShapiroRan KatzLiat AppelbaumGalina PizovKevin ZornEzekiel LandauMordechai DuvdevaniOfer Gofrit Source Type: research

Those with advanced bladder cancer may be helped by chemotherapy
DALLAS, May 7 (UPI) -- People who have their bladder removed because of advanced bladder cancer might need additional chemotherapy to prevent recurrence, U.S. researchers say. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 7, 2013 Category: Consumer Health News Source Type: news

Certain bladder-cancer patients may be at high risk of disease recurrence despite bladder removal
(UT Southwestern Medical Center) Patients with advanced bladder cancers that are surgically removed might need additional therapy to prevent recurrence in certain situations, a new UT Southwestern Medical Center study suggests. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 7, 2013 Category: Global & Universal Source Type: news

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer
lmström & K Jirström (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - May 7, 2013 Category: Cancer & Oncology Authors: K BomanA H LarssonU SegerstenE KuteevaH JohannessonB NodinJ EberhardM UhlénP-U MalmströmK Jirström Source Type: research

Actos Lawyers at Bernstein Liebhard LLP Comment on California Judge’s...
The Firm is currently investigating Actos lawsuits on behalf of type 2 diabetics who developed bladder cancer, allegedly due to long-term use of Actos.(PRWeb May 03, 2013)Read the full story at http://www.prweb.com/releases/actos-lawsuit/actos-bladder-cancer/prweb10700182.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 6, 2013 Category: Pharmaceuticals Source Type: news

Upper Egypt experience in bladder preservation using concurrent chemoradiotherapy
Conclusion: Three significant prognostic factors were detected for overall survival, performance status, tumor size and residual of tumor and two significant prognostic factors were detected for disease free survival, tumor size and residual of tumor in Assiut study. And it was nearly similar to that reported by Sohag study as they found the completeness of TUR and early stage of the tumor had the strongest impact in response to treatment. (Source: International Archives of Medicine)
Source: International Archives of Medicine - May 6, 2013 Category: Global & Universal Authors: Ahmed MakladElsayed AliAshraf ElyamanyEmad Nabil Source Type: research

Introduction of online adaptive radiotherapy for bladder cancer through a multicentre clinical trial (Trans-Tasman Radiation Oncology Group 10.01): Lessons learned
Daniel Pham, Paul Roxby, Tomas Kron, Aldo Rolfo, Farshad ForoudiJournal of Medical Physics 2013 38(2):59-66Online adaptive radiotherapy for bladder cancer is a novel radiotherapy technique that was found feasible in a pilot study at a single academic institution. In September 2010 this technique was opened as a multicenter study through the Trans-Tasman Radiation Oncology Group (TROG 10.01 bladder online adaptive radiotherapy treatment). Twelve centers across Australia and New-Zealand registered interest into the trial. A multidisciplinary team of radiation oncologists, radiation therapists and medical physicists represent...
Source: Journal of Medical Physics - May 3, 2013 Category: Physics Authors: Daniel PhamPaul RoxbyTomas KronAldo RolfoFarshad Foroudi Source Type: research

Genetic variations in micro-RNA biogenesis genes and clinical outcomes in non-muscle-invasive bladder cancer
Micro-RNAs (miRNAs) are small non-coding RNA molecules, which can act as either oncogenes or tumor suppressors. Dysregulated expression of miRNA genes have been implicated in the development of many different cancers. We hypothesize that genetic variations in miRNA biogenesis genes may be associated with the prognosis of bladder cancer. We genotyped 76 single nucleotide polymorphisms (SNPs) in eight miRNA biogenesis genes in 421 patients with non-muscle-invasive bladder cancer (NMIBC). We analyzed the associations of SNPs with recurrence and progression in all patients as well as stratified by treatment: transurethral rese...
Source: Carcinogenesis - May 3, 2013 Category: Cancer & Oncology Authors: Ke, H.-L., Chen, M., Ye, Y., Hildebrandt, M. A. T., Wu, W.-J., Wei, H., Huang, M., Chang, D. W., Dinney, C. P., Wu, X. Tags: Original Manuscript Source Type: research

Zinc and Copper Levels in Bladder Cancer: A Systematic Review and Meta-Analysis.
In conclusion, the disorder of Zn and Cu is closely associated with bladder cancer. Frequent monitoring and early intervention should be recommended. PMID: 23640281 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - May 3, 2013 Category: Biology Authors: Mao S, Huang S Tags: Biol Trace Elem Res Source Type: research

Judge reverses jury decision over $6.5m Takeda payout
Not enough evidence to link diabetes drug to bladder cancer, the company claims (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - May 2, 2013 Category: Chemistry Authors: Phillip Broadwith Source Type: research

OncoGenex Announces That The Borealis-2(TM) Clinical Trial Of OGX-427 In Previously Treated Metastatic Bladder Cancer Is Now Open For Enrollment
The OGX-427 ORCA™ Program Continues to Expand with Patient Enrollment Now Open for Second Phase 2 Trial of OGX-427 in Advanced Bladder Cancer OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI) have announced initiation of the Borealis-2™ clinical trial, an investigator-sponsored, randomized Phase 2 trial evaluating OGX-427 in combination with docetaxel in patients with advanced or metastatic bladder cancer who have disease progression following first-line platinum-based chemotherapy treatment... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 2, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Actos to Blame for Bladder Cancer, Alleges Lawsuit Filed by Parker...
Parker Waichman LLP is representing a New York woman in a lawsuit alleging that Actos (pioglitazone) caused bladder cancer. The suit alleges that Takeda and other Defendants knew about the risk of...(PRWeb May 01, 2013)Read the full story at http://www.prweb.com/releases/actos-bladdercancer/052013/prweb10692095.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 2, 2013 Category: Pharmaceuticals Source Type: news

Robotic radiosurgery: emulating brachytherapy in patients with locally advanced cervical carcinoma. Technique, feasibility and acute toxicity
Conclusions: CyberKnife robotic radiosurgery in patients with cervical cancer provides excellent target coverage with steep dose gradients toward normal tissues and safe DVH parameters for bladder, rectum and sigmoid. Acute toxicity was mild. Longer follow-up is needed to evaluate the oncological benefit. (Source: Radiation Oncology)
Source: Radiation Oncology - May 2, 2013 Category: Cancer & Oncology Authors: Simone MarnitzChristhardt KöhlerVolker BudachOliver NeumannAnne KlugeWaldemar WlodarczykUlrich JahnBernhard GebauerMarkus Kufeld Source Type: research

Meprin A metalloproteinase and its role in acute kidney injury
Meprin A, composed of α- and β-subunits, is a membrane-associated neutral metalloendoprotease that belongs to the astacin family of zinc endopeptidases. It was first discovered as an azocasein and benzoyl-l-tyrosyl-p-aminobenzoic acid hydrolase in the brush-border membranes of proximal tubules and intestines. Meprin isoforms are now found to be widely distributed in various organs (kidney, intestines, leukocytes, skin, bladder, and a variety of cancer cells) and are capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, ...
Source: AJP: Renal Physiology - May 1, 2013 Category: Urology & Nephrology Authors: Kaushal, G. P., Haun, R. S., Herzog, C., Shah, S. V. Tags: REVIEWS Source Type: research

Surgery for Metastasis to the Pancreas: Is it Safe and Effective?
ConclusionsDespite the operative risk involved, we believe that pancreatic resection should be considered in selected patients with good performance status, stable disease and isolated pancreatic metastases. J. Surg. Oncol. 2013 9999:XX–XX. © 2013 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - May 1, 2013 Category: Cancer & Oncology Authors: Hanno Niess, Claudius Conrad, Axel Kleespies, Florian Haas, Qi Bao, Karl‐Walter Jauch, Christian Graeb, Christiane J. Bruns Tags: Research Article Source Type: research