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Whole exome sequencing of adenoid cystic carcinoma
Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular underpinnings, little else is known about the molecular genetics of this frequently fatal cancer. We have undertaken exome sequencing in a series of 24 ACC to further delineate the genetics of the disease. We identified multiple mutated genes that, combined, implicate chromatin deregulation in half of cases. Further, mutations were identified in known cancer genes, including PIK3C...
Source: Journal of Clinical Investigation - June 17, 2013 Category: Biomedical Science Authors: Philip J. Stephens, Helen R. Davies, Yoshitsugu Mitani, Peter Van Loo, Adam Shlien, Patrick S. Tarpey, Elli Papaemmanuil, Angela Cheverton, Graham R. Bignell, Adam P. Butler, John Gamble, Stephen Gamble, Claire Hardy, Jonathan Hinton, Mingming Jia, Alagu Source Type: research
Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
e Gilks & David G Huntsman (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 14, 2013 Category: Pathology Authors: Melissa K McConechyJiarui DingJanine SenzWinnie YangNataliya MelnykAlicia A ToneLeah M PrenticeKimberly C WiegandJessica N McAlpineSohrab P ShahCheng-Han LeePaul J GoodfellowC Blake GilksDavid G Huntsman Tags: carcinoma CTNNB1 endometrial endometrioid mutations ovarian PTEN Source Type: research
Toward standard HER2 testing of endometrial serous carcinoma: 4-year experience at a large academic center and recommendations for clinical practice
& Pei Hui (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 14, 2013 Category: Pathology Authors: Natalia BuzaDiana P EnglishAlessandro D SantinPei Hui Tags: endometrial serous carcinoma fluorescent in situ hybridization HER2 testing heterogeneity immunohistochemistry Source Type: research
Hormone therapy for endometrial cancer targets connective tissue, not tumor cells
In this study, we found that all of the progesterone anti-tumor effects are in fact mediated through the stroma, even though it makes up a minor fraction of the tumor. I believe these exciting findings are going to surprise the clinical community and change the way people look at patterns of hormone-receptor expression in endometrial tumors." The results of the three-year study, done using a specially developed laboratory model created by Memarzadeh's team that closely mimics human endometrial cancer, appear in the early online edition of Cancer Research, a peer-reviewed journal of the American Association for Cance...
Source: UCLA Newsroom: Health Sciences - June 13, 2013 Category: Universities & Medical Training Source Type: news
Malignant Cells Not Directly Targeted By Hormonal Treatment For Endometrial Cancer
Progesterone, a female hormone that can be used as a therapy for endometrial cancer, eliminates tumor cells indirectly by binding to its receptor in stromal or connective tissue cells residing in the tumor microenvironment, according to a study from the G.O. Discovery Lab team and collaborators at UCLA. Like tumors of the breast and prostate, endometrial cancer is regulated by hormones. Unlike therapies for breast and prostate cancer, where drugs are given to block hormone signaling, in therapy for endometrial cancer progesterone is given to stimulate its hormone receptor... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 13, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial
Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial British Journal of Cancer advance online publication, June 13 2013. doi:10.1038/bjc.2013.282 Authors: V Seebacher, G Hofstetter, S Polterauer, A Reinthaller, C Grimm, R Schwameis, S Taucher, A Wagener, C Marth & N Concin (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - June 13, 2013 Category: Cancer & Oncology Authors: V SeebacherG HofstetterS PolterauerA ReinthallerC GrimmR SchwameisS TaucherA WagenerC MarthN Concin Source Type: research
Hypoxia‐dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression
In this study, we investigated the hypoxia‐dependency of YT521 expression as well as its differential isoform activities on oncological important target genes. YT521's potential regulatory influence on splicing was investigated by a minigene assay for the specific target gene CD44. Functional splicing analysis was performed by YT521 knock‐down or overexpression, respectively. In addition, YT521 expression was determined under hypoxia. The two protein‐generating YT521 mRNA isoforms 1 and 2 caused a comparable, specific induction of CD44v alternative splicing (P < 0.01). In a number of oncological target genes, ...
Source: Molecular Carcinogenesis - June 13, 2013 Category: Molecular Biology Authors: Marc Hirschfeld, Bo Zhang, Markus Jaeger, Stefan Stamm, Thalia Erbes, Sebastian Mayer, Xiaowen Tong, Elmar Stickeler Tags: Research Article Source Type: research
Molecular pathogenesis of endometrial cancers in patients with Lynch syndrome
CONCLUSIONSHyperplasia, particularly CAH, is part of the preinvasive spectrum of disease in LS‐associated EC, as indicated by the presence of complex hyperplasia and CAH in cases of LS. Although loss of PTEN is common in both LS and sporadic EC cases, there was a lack of additional mutations in LS‐associated EC cases. This suggests that in the context of the mismatch repair defects in LS, fewer additional molecular changes are required to progress from preinvasive lesions to cancer. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - June 12, 2013 Category: Cancer & Oncology Authors: Marilyn Huang, Bojana Djordjevic, Melinda S. Yates, Diana Urbauer, Charlotte Sun, Jennifer Burzawa, Molly Daniels, Shannon N. Westin, Russell Broaddus, Karen Lu Tags: Original Article Source Type: research
Erratum: Integrated genomic characterization of endometrial carcinoma
Nature advance online publication 12 June 2013. doi:10.1038/nature12325 Author: (Source: Nature AOP)
Source: Nature AOP - June 12, 2013 Category: Research Tags: Erratum Source Type: research
Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk‐1‐dependent Mcl‐1 transcription and inducing Akt/GSK3β‐dependent protein degradation
Abstract Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95‐2). Sorafenib induced cell death in EC cells with the following order of sensitivity: HEC1A > HEC1B > RL95‐2. Sorafenib suppressed several anti‐apoptotic proteins in HEC1A cells, including myeloid cell leukemia 1 (Mcl‐1). Ectopic overexpression of Mcl‐1 prevented the cell killing effect of sorafenib. Sorafenib suppresse...
Source: Journal of Cellular Biochemistry - June 11, 2013 Category: Biochemistry Authors: Nian‐Kang Sun, Shang‐Lang Huang, Ting‐Chang Chang, Chuck C.‐K. Chao Tags: Article Source Type: research
Hormonal treatment for endometrial cancer does not directly target the malignant cells
(University of California - Los Angeles Health Sciences) Rogesterone, a female hormone that can be used as a therapy for endometrial cancer, eliminates tumor cells indirectly by binding to its receptor in connective tissue cells residing in the tumor microenvironment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 10, 2013 Category: Global & Universal Source Type: news
Adrenocortical Carcinoma Is a Lynch Syndrome-Associated Cancer.
CONCLUSIONThe prevalence of LS among patients with ACC is 3.2%, which is comparable to the prevalence of LS in colorectal and endometrial cancer. Patients with ACC and a personal or family history of LS tumors should be strongly considered for genetic risk assessment. IHC screening of all ACC tumors may be an effective strategy for identifying patients with LS. PMID: 23752102 [PubMed - as supplied by publisher] (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - June 10, 2013 Category: Cancer & Oncology Authors: Raymond VM, Everett JN, Furtado LV, Gustafson SL, Jungbluth CR, Gruber SB, Hammer GD, Stoffel EM, Greenson JK, Giordano TJ, Else T Tags: J Clin Oncol Source Type: research
Concomitant Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Broad Ligament and Endometrioid Endometrial Adenocarcinoma
Journal of Gynecologic Surgery , Vol. 0, No. 0. (Source: Journal of Gynecologic Surgery)
Source: Journal of Gynecologic Surgery - June 8, 2013 Category: OBGYN Tags: article Source Type: research
ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma
er Matias-Guiu, Robert A Soslow & José Palacios (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 7, 2013 Category: Pathology Authors: Laura Romero-PérezM Ángeles López-GarcíaJuan Díaz-MartínMichele BiscuolaM Ángeles CastillaLaura J TafeKaruna GargEsther OlivaXavier Matias-GuiuRobert A SoslowJosé Palacios Tags: E-cadherin miR-200s undifferentiated endometrial carcinoma ZEB1 Source Type: research
Genotype Misclassification in Genetic Association Studies of the rs1042522 TP53 (Arg72Pro) Polymorphism: A Systematic Review of Studies of Breast, Lung, Colorectal, Ovarian, and Endometrial Cancer
Preferential loss of heterozygosity at the rs1042522 locus of the tumor protein 53 gene (TP53) (Arg72Pro) is observed in several tumors. Genetic association studies in oncology often use tumor tissue rather than unaffected tissue for genotyping; in such cases, loss of heterozygosity at the TP53 locus could lead to differential misclassification and could bias estimates of association. We searched multiple databases (through March 8, 2011) for studies investigating the association of Arg72Pro with breast, lung, colorectal, ovarian, or endometrial cancer. Meta-analysis was performed with multilevel Bayesian models. Informati...
Source: American Journal of Epidemiology - June 7, 2013 Category: Epidemiology Authors: Dahabreh, I. J., Schmid, C. H., Lau, J., Varvarigou, V., Murray, S., Trikalinos, T. A. Tags: RESEARCH-ARTICLE Source Type: research
Anthropometric Measures and the Risk of Endometrial Cancer, Overall and by Tumor Microsatellite Status and Histological Subtype
Obesity is an established risk factor for endometrial cancer, but this association is not well understood for subtypes of endometrial cancer. We evaluated the association of recent and adult-life obesity with subtypes of endometrial cancer based on microsatellite status (microsatellite-stable (MSS) vs. microsatellite-instable (MSI)) and histology (type I vs. type II). Analyses were based on a population-based case-control study (524 cases and 1,032 controls) conducted in Alberta, Canada (2002–2006) and included the following groupings of subtypes: MSS = 337 and MSI = 130; type I = 458 and type II = 66. Logistic and p...
Source: American Journal of Epidemiology - June 7, 2013 Category: Epidemiology Authors: Amankwah, E. K., Friedenreich, C. M., Magliocco, A. M., Brant, R., Courneya, K. S., Speidel, T., Rahman, W., Langley, A. R., Cook, L. S. Tags: RESEARCH-ARTICLE Source Type: research
Ovarian Cancer Incidence Trends in Relation to Changing Patterns of Menopausal Hormone Therapy Use in the United States [Gynecologic Cancer]
Conclusion After a marked reduction in MHT use around 2002, ovarian cancer incidence rates demonstrated an accelerated decline, with the largest changes for endometrioid carcinomas. This strong temporal association, although not proving a causal role of hormones in ovarian carcinogenesis, suggests that future analytic research supporting cancer control efforts should clarify the role of hormonal exposures on the development and behavior of subtypes of ovarian cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 7, 2013 Category: Cancer & Oncology Authors: Yang, Anderson, Rosenberg, Trabert, Gierach, Wentzensen, Cronin, Sherman Tags: Epidemiology Gynecologic Cancer Source Type: research
Hormonal Therapy for Women With Stage IA Endometrial Cancer of All Grades.
CONCLUSION:: Progestin treatment appears to be reasonably effective for patients with stage IA, grade 2-3 differentiation without myometrial invasion and patients with stage IA grade 1 differentiation with superficial myometrial invasion. LEVEL OF EVIDENCE:: III. PMID: 23743459 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 5, 2013 Category: OBGYN Authors: Park JY, Kim DY, Kim TJ, Kim JW, Kim JH, Kim YM, Kim YT, Bae DS, Nam JH Tags: Obstet Gynecol Source Type: research
Loss of Cdh1 and Pten Accelerates Cellular Invasiveness and Angiogenesis in the Mouse Uterus.
In this study, we characterized the impact of dual Cdh1 and Pten ablation (Cdh1(d/d) Pten(d/d)) in the mouse uterus. We observed that (Cdh1(d/d) Pten(d/d) mice died at Postnatal Day 15-19 with massive blood loss. Their uteri were abnormally structured with curly horns, disorganized epithelial structure, and increased cell proliferation. Co-immunostaining of KRT8 and ACTA2 showed invasion of epithelial cells into the myometrium. Further, the uteri of (Cdh1(d/d) Pten(d/d) mice had prevalent vascularization in both the endometrium and myometrium. We also observed reduced expression of estrogen and progesterone receptors, loss...
Source: Biology of Reproduction - June 5, 2013 Category: Reproduction Medicine Authors: Lindberg ME, Stodden GR, King ML, Maclean JA, Mann JL, Demayo FJ, Lydon JP, Hayashi K Tags: Biol Reprod Source Type: research
Silencing of Ghrelin Receptor Expression Inhibits Endometrial Cancer Cell Growth in vitro and in vivo.
Abstract Ghrelin is a 28 amino acid peptide hormone produced predominantly in the stomach, but also in a range of normal cell types and tumours, where it has endocrine, paracrine, and autocrine roles. We have previously demonstrated that ghrelin has proliferative and anti-apoptotic effects in endometrial cancer cell lines, suggesting a potential role in promoting tumour growth. In the present study, we investigated the effect of ghrelin receptor, GHSR, gene silencing in vitro and in vivo, and characterized ghrelin and GHSR1a protein expression in human endometrial tumours. GHSR gene silencing was achieved in the Is...
Source: American Journal of Physiology. Endocrinology and Metabolism - June 4, 2013 Category: Physiology Authors: Fung JN, Jeffery PL, Lee JD, Seim I, Roche D, Obermair A, Chopin LK, Chen C Tags: Am J Physiol Endocrinol Metab Source Type: research
Deciduoid mesothelial hyperplasia of the pelvic peritoneum
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - June 3, 2013 Category: Pathology Authors: Colin JR Stewart Tags: Correspondence Source Type: research
MicroRNA‐503 suppresses proliferation and cell cycle progression of endometrioid ndometrial cancer via negatively regulating cyclin D1
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - June 3, 2013 Category: Research Authors: Yan‐Ying Xu, Hui‐Juan Wu, Hong‐Da Ma, Li‐Ping Xu, Yan Huo, Li‐Rong Yin Tags: Original Article Source Type: research
Tamoxifen boost for breast cancer sufferers
Study finds that death rates fall significantly for patients who take the drug for 10 years rather than the standard fiveBreast cancer is less likely to recur if women previously treated for the disease take the drug tamoxifen for 10 years, instead of the recommended five, according to a British study. The study was a component of a larger international trial for which similar results were announced last year.Researchers estimated that, compared with taking no tamoxifen, 10 years of the drug reduces breast cancer death rates by a third in the first 10 years and by half after that. "Until now, there have been doubts whether...
Source: Guardian Unlimited Science - June 2, 2013 Category: Science Tags: The Guardian News Health Medical research Society Drugs UK news Breast cancer Science Source Type: news
A novel DPSO-SVM system for variable interval selection of endometrial tissue sections by near infrared spectroscopy.
Abstract A novel method combining a discrete particle swarm optimization (DPSO) with a support vector machine (SVM) was proposed for the variable interval selection of tissue sections of endometrial carcinoma by near infrared spectroscopy. The DPSO-SVM algorithm includes a multi-stage screening. In each screening step, the DPSO was repeated 50 times using random sampling, and the frequencies that the variable intervals were selected among the 50 repeats were used to select the most probable intervals. The variable intervals with high probabilities were selected and further used in the next screening. Finally, the s...
Source: Talanta - June 1, 2013 Category: Chemistry Authors: Wang G, Ma M, Zhang Z, Xiang Y, Harrington Pde B Tags: Talanta Source Type: research
Utility of Ki‐67, p53, Bcl‐2, and Cox‐2 biomarkers for low‐grade endometrial cancer and disordered proliferative/benign hyperplastic endometrium by imprint cytology
In this report, the authors examined the characteristic features of morphology and molecular biology of Ki‐67, p53, Bcl‐2, and cyclooxygenase‐2 (Cox‐2) immunocytochemistry in low‐grade endometrioid endometrial carcinoma (LG‐ENEC) and disordered proliferative (DP)/benign hyperplastic (BH) endometrium. We carried out a prospective study by collecting endometrial imprints from freshly resected uteri over a 20‐month period and finally 104 patients were evaluated with endometrial cytology. We focused on LG‐ENECs, as well as on BH endometrium and its precursor lesion, DP endometrium, firstly because of the overla...
Source: Diagnostic Cytopathology - June 1, 2013 Category: Pathology Authors: George Apostolou, Nicolaos Apostolou, Maria Biteli, Nikolaos Kavantzas, Efstratios Patsouris, Paulina Athanassiadou Tags: Original Article Source Type: research
ProExC is a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas.
CONCLUSION: ProExC is a novel immunohistochemical marker for differentiating ECA from EMA and its inclusion in a panel of immunohistochemical markers including p16, ER, PR, and vimentin is recommended when there is morphological and clinical doubt as to the primary site of endocervical or endometrial origin. PMID: 23719407 [PubMed - in process] (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - June 1, 2013 Category: Cancer & Oncology Authors: Esheba GE Tags: J Egypt Natl Canc Inst Source Type: research
Current surgical treatment option, utilizing robot-assisted laparoscopic surgery in obese women with endometrial cancer: Farghaly's technique.
CONCLUSION: Robot-assisted laparoscopic surgical staging, and panniculectomy in these patients are a safe, and effective alternative to laparoscopic, and laparotomy surgery. It is an ideal tool for performing the complex oncologic procedures encountered in endometrial cancer staging that requires delicate retroperitoneal, pelvic and para-aortic lymph node dissection, while maintaining the principles of oncologic surgery but in a minimally invasive fashion. PMID: 23719403 [PubMed - in process] (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - June 1, 2013 Category: Cancer & Oncology Authors: Farghaly SA Tags: J Egypt Natl Canc Inst Source Type: research
Risk of Colorectal Cancer After Diagnosis of Endometrial Cancer: A Population-Based Study [Epidemiology]
Conclusion This study suggests young women (age ≤ 50 years) with EC are at increased risk of CRC; risk of right-sided CRC is also increased in women 51 to 65 years old at EC diagnosis. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 29, 2013 Category: Cancer & Oncology Authors: Singh, Nugent, Demers, Czaykowski, Mahmud Tags: Epidemiology, Outcomes Research Source Type: research
Distinct molecular profiles in Lynch syndrome‐associated and sporadic ovarian carcinomas
In conclusion, the significant molecular differences observed between LS‐associated and sporadic ovarian carcinomas help explain the different behavior of these tumors and emphasize the need for tailored clinical management. (Source: International Journal of Cancer)
Source: International Journal of Cancer - May 28, 2013 Category: Cancer & Oncology Authors: Anni Niskakoski, Sippy Kaur, Laura Renkonen‐Sinisalo, Heini Lassus, Heikki J. Järvinen, Jukka‐Pekka Mecklin, Ralf Bützow, Päivi Peltomäki Tags: Cancer Genetics Source Type: research
Typical and atypical metastatic sites of recurrent endometrial carcinoma.
Abstract The purpose of this article is to illustrate the imaging findings of typical and atypical metastatic sites of recurrent endometrial carcinoma. Typical sites include local pelvic recurrence, pelvic and para-aortic nodes, peritoneum, and lungs. Atypical sites include extra-abdominal lymph nodes, liver, adrenals, brain, bones and soft tissue. It is important for radiologists to recognize the typical and atypical sites of metastases in patients with recurrent endometrial carcinoma to facilitate earlier diagnosis and treatment. PMID: 23545091 [PubMed - in process] (Source: Cancer Imaging)
Source: Cancer Imaging - May 26, 2013 Category: Radiology Authors: Kurra V, Krajewski KM, Jagannathan J, Giardino A, Berlin S, Ramaiya N Tags: Cancer Imaging Source Type: research
Reporting of Quality Measures in Gynecologic Oncology Programs at Prospective Payment System (PPS)-Exempt Cancer Hospitals: An Early Glimpse into a Challenging Initiative.
CONCLUSIONS: There is wide variability in ranking of quality measures, and may relate to provider or institutional factors. Despite the mandatory reporting in PPS-exempt cancer hospitals, work remains to define gynecologic cancer quality measures. PMID: 23718934 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 26, 2013 Category: Cancer & Oncology Authors: Cohn DE, Leitao M, Levenback C, Berkowitz R, Roman L, Lucci J, Kim S, Lancaster J, Odunsi K, Wakabayashi M, Goff BA Tags: Gynecol Oncol Source Type: research
The effect of statins on risk and survival of gynecological malignancies.
CONCLUSION: The use of statins for more than one year before diagnosis was associated with a reduction in the risk of endometrial cancer and possibly ovarian cancer. A significantly improved survival of cases of both malignancies was noticed when statins were taken only after diagnosis. PMID: 23718932 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 26, 2013 Category: Cancer & Oncology Authors: Lavie O, Pinchev M, Rennert HS, Segev Y, Rennert G Tags: Gynecol Oncol Source Type: research
Primary pure squamous cell carcinoma of the endometrium: a case report.
Abstract Because primary pure squamous cell carcinoma (SCC) of the endometrium is very rare and its frequency is unknown, the author reviewed 142 archival hysterectomy specimens of endometrial cancers. As the results, one case of primary pure SCC was found. Thus, the frequency of SCC of the endometrium was 0.7% of all endometrial malignancies in our institution. The patient was a 72-year-old woman presenting with uterine bleeding. Uterine curettage biopsy and uterine discharge cytology revealed SCC. No malignancy was seen in cervical biopsy. Radical hysterectomy, bilateral salpingo-oophorectomy, omentectomy and lym...
Source: International Journal of Clinical and Experimental Pathology - May 25, 2013 Category: Pathology Authors: Terada T, Tateoka K Tags: Int J Clin Exp Pathol Source Type: research
Upregulation of URI/RMP gene expression in cervical cancer by high-throughput tissue microarray analysis.
Abstract URI, or RMP, is a RNA polymerase II subunit RPB5-associated protein known to play essential roles in ubiquitination and transcription. Recently, we and others have shown that URI/RMP is also important for progression of hepatocellular carcinoma, ovarian, and prostate cancers. To identify the mechanistic basis of URI/RMP during multiple cellular processes, we investigated URI/RMP expression in a tissue microarray (TMA) containing multiple normal human tissues. The results showed that URI/RMP is ubiquitously but differentially expressed in these human tissues which partially explains its multiple cellular fu...
Source: International Journal of Clinical and Experimental Pathology - May 25, 2013 Category: Pathology Authors: Gu J, Li X, Liang Y, Qiao L, Ran D, Lu Y, Li X, Wei W, Zheng Q Tags: Int J Clin Exp Pathol Source Type: research
Obesity-driven endometrial cancer: is weight loss the answer?
PMID: 23659328 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 25, 2013 Category: OBGYN Authors: Mackintosh M, Crosbie E Tags: BJOG Source Type: research
Inorganic phosphate and the risk of cancer in the Swedish AMORIS study
Conclusions: Abnormal Pi levels are related to development of cancer. Furthermore, the in verse association between Pi levels and risk of breast, endometrial and other endocrine cancers may indicate the role of hormonal factors in the relation between Pi metabolism and cancer. (Source: BMC Cancer)
Source: BMC Cancer - May 24, 2013 Category: Cancer & Oncology Authors: Wahyu WulaningsihKarl MichaelssonHans GarmoNiklas HammarIngmar JungnerGöran WalldiusLars HolmbergMieke Van Hemelrijck Source Type: research
Utilization of genomic signatures to identify high‐efficacy candidate drugs for chemorefractory endometrial cancers
Endometrial cancer, one of the most common gynecologic malignancies, is increasing in Japan, nearly doubling over the last decade. High‐grade disease patients are often resistant to conventional chemotherapy with platinum agents; therefore, discovery of efficacious new drugs in this setting is required to benefit chemorefractory cases. The 50% growth‐inhibitory (GI50) concentration of 27 clinically relevant drugs was measured in the NCI60 panel of cell lines. Gene expression data were analyzed using Bayesian binary regression, to first generate a response signature for each drug and then to calculate individual suscept...
Source: International Journal of Cancer - May 24, 2013 Category: Cancer & Oncology Authors: Budiman Kharma, Tsukasa Baba, Masaki Mandai, Noriomi Matsumura, Susan K. Murphy, Hyun Sook Kang, Koji Yamanoi, Junzo Hamanishi, Ken Yamaguchi, Yumiko Yoshioka, Ikuo Konishi Tags: Cancer Cell Biology Source Type: research
Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer
& Vincent THBM Smit (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - May 24, 2013 Category: Pathology Authors: Tjalling BosseNatalja T ter HaarLaura M SeeberPaul J v DiestFrederik J HesHans FA VasenRemi A NoutCarien L CreutzbergHans MorreauVincent THBM Smit Tags: ARID1A endometrial cancer Lynch syndrome microsatellite instability Source Type: research
Cystic Variant of Endometrial Stromal Sarcoma: Report of Two Cases
We report 2 cases of endometrial stromal sarcoma with a prominent cystic appearance, forming multilocular cystic mass, detected by ultrasonography. The differential diagnosis among multycistic endometrial stromal sarcoma and cystic uterine tumors might be very difficult. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - May 23, 2013 Category: Pathology Authors: Somma, A., Falleti, J., Di Simone, D., Marra, A., Nazzaro, G., Miranda, M., Insabato, L. Tags: Case Reports Source Type: research
A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.
Abstract The mutant forms of KRas, NRas and HRas drive the initiation and progression of a number of human cancers, but less is known about the role of WT (wild-type) Ras alleles and isoforms in cancer. We used zinc-finger nucleases targeting HRas and NRas to modify both alleles of these genes in the mutant KRas-driven Hec1A endometrial cancer cell line, which normally expresses WT copies of these genes. The disruption of either WT isoform of Ras compromised growth-factor-dependent signalling through the ERK (extracellular-signal-regulated kinase) pathway. In addition, the disruption of HRas hindered the activation...
Source: The Biochemical Journal - May 22, 2013 Category: Biochemistry Authors: Bentley C, Jurinka SS, Kljavin NM, Vartanian S, Ramani SR, Gonzalez LC, Yu K, Modrusan Z, Du P, Bourgon R, Neve RM, Stokoe D Tags: Biochem J Source Type: research
Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases.
Conclusions: The strong expression of PRL-3 in the primary tumor that was significantly correlated with the grade and clinical stage suggest that PTP4A3 participates in the process of endometrial carcinogenesis. PMID: 23729584 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 22, 2013 Category: Biomedical Science Authors: Guzińska-Ustymowicz K, Kiśluk J, Terlikowski SJ, Pryczynicz A, Niewiarowska K, Ustymowicz M, Hawryluk M, Południewski M, Kemona A Tags: Adv Med Sci Source Type: research
A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence
& R Sinha (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - May 21, 2013 Category: Cancer & Oncology Authors: H AremM J GunterA J CrossA R HollenbeckR Sinha Source Type: research
VEGF-c expression in an in vivo model of orthotopic endometrial cancer and retroperitoneal lymph node metastasis
Conclusion: Injection of a VX2 cell suspension is a simple method of establishing an in vivo EC model. VEGF-c may play an important role in the development of EC and its metastasis to RLN and may be useful marker to predict RLN metastasis. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 21, 2013 Category: Endocrinology Authors: Yong-Wen HuangLi-Qun XuRong-Zhen LuoXin HuangTeng HouYan-Na Zhang Source Type: research
Hysterectomy for cancer – Trudy’s Story
Hi, I have been off work for shoulder surgery work related. During that time I found out after my pap smear was abnormal that I needed a endometrial biopsy which confirmed uterine cancer. Less than a month after that I had a robotic total hysterectomy. Everything including my cervix was removed. The resident told me I would be off work 4 to 6 weeks. My work disability is giving me off till 5/28/13. I had this procedure on May 1st ,2013. I am still on light duty til 6/6/2013 for my shoulder. I am a nurse who works 12.5 hours a day but not every day. I push a med cart with a computer. Wash, turn, lift patients getting them ...
Source: The Hysterectomy Association - May 20, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Cancer Recovery Your Stories davinci hysterectomy return to work after hysterectomy robotic hysterectomy total hysterectomy Uterine Cancer Source Type: news
Validation of suitable endogenous control genes for quantitative PCR analysis of microRNA gene expression in a rat model of endometrial cancer
Conclusion: This study identified the control gene that is most suitable for normalizing the miRNA expression data in rat. That reference gene will be useful when miRNAs expression are analyzed in order to find new miRNA markers for endometrial cancer in rat. (Source: Cancer Cell International)
Source: Cancer Cell International - May 16, 2013 Category: Cancer & Oncology Authors: Sanja JurcevicBjörn OlssonKarin Klinga-Levan Source Type: research
CpG island hypermethylation-associated silencing of microRNAs promotes human endometrial cancer
Conclusions: Our study provides the first description of epigenetic modification of epithelial mesenchymal transition associated genes and miRNAs in EC cells, which are extensively involved in the regulation of gene expression and subsequent accumulation of malignant features of EC cells. (Source: Cancer Cell International)
Source: Cancer Cell International - May 16, 2013 Category: Cancer & Oncology Authors: Bi-Lan LiWen LuCong LuJun-jie QuTing-ting YangQin YanXiao-ping Wan Source Type: research
60 years of data suggest a link between obesity and height in childhood and endometrial cancer in adulthood (Medical News Today, 14 May 2013)
A study from Denmark presented at the European Congress on Obesity assesses whether risk of developing endometrial cancer in adulthood may originate in part in childhood. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - May 15, 2013 Category: Endocrinology Source Type: news
Expression patterns of Phf5a/PHF5A and Gja1/GJA1 in rat and human endometrial cancer
Endometrial adenocarcinoma is the most frequently diagnosed cancer of the female genital tract in the western world. Studies of complex diseases can be difficult to perform on human tumor samples due to the high genetic heterogeneity in human. The use of rat models is preferable since rat has similarities in pathogenesis and histopathological properties to that of human.A genomic region including the highly conserved Phf5a gene associated to development of EAC has previously been identified in an association study. PHF5A has been suggested to acts as a transcription factor or cofactor in the up regulation of expression of ...
Source: Cancer Cell International - May 15, 2013 Category: Cancer & Oncology Authors: Eva FalckKarin Klinga-Levan Source Type: research
60 Years Of Data Suggest A Link Between Obesity And Height In Childhood And Endometrial Cancer In Adulthood
New research presented at the European Congress in Liverpool (ECO) beginning today (Sunday 12 May) shows a possible link between obesity and height in childhood and endometrial cancer in adulthood. The research* is by Julie Aarestrup, Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark, and colleagues. Endometrial cancer is in Europe the fourth most common cancer in women with more than 90,000 new cases diagnosed each year... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 14, 2013 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news
Genetics: New classification for endometrial cancer puts genes in POLE position
Nature Reviews Clinical Oncology 10, 304 (2013). doi:10.1038/nrclinonc.2013.82 Author: Rebecca Kirk Results that have been published by The Cancer Genome Atlas (TCGA) Research Network in a range of cancers have revealed novel insights into their genetic background and potential targets for therapy. Now, it's the turn of endometrial cancer. Douglas Levine has led the team in (Source: Nature Clinical Practice Oncology)
Source: Nature Clinical Practice Oncology - May 14, 2013 Category: Cancer & Oncology Authors: Rebecca Kirk Tags: Research Highlight Source Type: research