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This page shows you the latest news and research items in this category.

Significance of CD133 expression in esophageal squamous cell carcinoma
Conclusions: This study indicated that CD133 immunoreactivity is a good predictor of prognosis in ESCC patients. In addition, CD133 may play a role in the regulation of tumor cell cycle through p27 and p16 in ESCC. At present, it thus remains controversial whether CD133 expression is a valid prognostic marker for ESCC. To elucidate this relationship, further investigations are required. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - March 1, 2013 Category: Cancer & Oncology Authors: Hiroshi OkamotoFumiyoshi FujishimaYasuhiro NakamuraMasashi ZuguchiYohei OzawaYayoi TakahashiGo MiyataTakashi KameiToru NakanoYusuke TaniyamaJin TeshimaMika WatanabeAkira SatoNoriaki OhuchiHironobu Sasano Source Type: research

Surgical Treatment for Limited-Stage Primary Small Cell Cancer of the Esophagus [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions Although the standard treatment protocol for PSCCE has not been established, the results of our study indicated that radical esophagectomy with extended lymphadenectomy should be considered as the primary treatment for patients with limited-stage PSCCE, particularly for those without regional lymph node involvement. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Situ, D., Lin, Y., Long, H., Zhang, L., Lin, P., Zheng, Y., Jiang, L., Tan, Z., Meng, Y., Ma, G. Tags: Esophagus - cancer ORIGINAL ARTICLES: GENERAL THORACIC Source Type: research

Invited Commentary [ORIGINAL ARTICLES: GENERAL THORACIC]
(Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Landreneau, R. J. Tags: Esophagus - cancer ORIGINAL ARTICLES: GENERAL THORACIC Source Type: research

Repair of a Complex Bronchogastric Fistula After Esophagectomy With Biologic Mesh [CASE REPORTS]
We report a case of a patient transferred to our institution with a complex bronchogastric conduit fistula after a thoracoscopic three-hole esophagectomy for midesophageal squamous cell carcinoma. The defect involved the entire membranous airway of the bronchus intermedius, with a 15-cm dehiscence of the gastric conduit staple line. This was successfully reconstructed with a single-stage repair by use of an Alloderm patch reinforced with an intercostal muscle flap. At postoperative follow-up the patient is doing well and tolerating a regular diet without dysphagia. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Reames, B. N., Lin, J. Tags: Esophagus - cancer CASE REPORTS Source Type: research

Selective Resection Feasible for Esophageal Cancer
SAN FRANCISCO (IMNG) - Five-year survival rates for 41 patients with locoregionally advanced esophageal cancer who underwent induction chemotherapy and definitive chemoradiotherapy were 53% for patients... (Source: OncologySTAT Latest News)
Source: OncologySTAT Latest News - February 27, 2013 Category: Cancer & Oncology Source Type: news

Accuracy and interrater reliability for the diagnosis of Barrett's neoplasia among users of a novel, portable high‐resolution microendoscope
Summary The high‐resolution microendoscope (HRME) is a novel imaging modality that may be useful in the surveillance of Barrett's esophagus in low‐resource or community‐based settings. In order to assess accuracy and interrater reliability of microendoscopists in identifying Barrett's‐associated neoplasia using HRME images, we recruited 20 gastroenterologists with no microendoscopic experience and three expert microendoscopists in a large academic hospital in New York City to interpret HRME images. They prospectively reviewed 40 HRME images from 28 consecutive patients undergoing surveillance for metaplasia and low...
Source: Diseases of the Esophagus - February 26, 2013 Category: Gastroenterology Authors: P. M. Vila, M. J. Kingsley, A. D. Polydorides, M.‐A. Protano, M. C. Pierce, J. Sauk, M. K. Kim, K. Patel, J. H. Godbold, J. D. Waye, R. Richards‐Kortum, S. Anandasabapathy Tags: Original article Source Type: research

Endoscopic submucosal dissection for superficial esophageal neoplasms using the stag beetle knife
In conclusion, ESD using the SB knife was safer than that using a conventional knife for superficial esophageal neoplasms. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - February 26, 2013 Category: Gastroenterology Authors: H. Fujinami, A. Hosokawa, K. Ogawa, J. Nishikawa, S. Kajiura, T. Ando, A. Ueda, H. Yoshita, T. Sugiyama Tags: Original article Source Type: research

Feasibility of endoscopic mucosal resection as salvage treatment for patients with local failure after definitive chemoradiotherapy for stage IB, II, and III esophageal squamous cell cancer
Summary Local failure after definitive chemoradiotherapy (CRT) for stage IB, II, and III esophageal cancer is one of the causes of poor outcome. Endoscopic mucosal resection (EMR) is an effective treatment for superficial esophageal cancer. However, its feasibility as a salvage treatment for local recurrent or residual tumors after definitive CRT for stage IB, II, and III esophageal cancer remains unclear. Between January 2000 and February 2008, 274 patients with stage IB, II, and III esophageal squamous cell cancer excluding T4 received definitive CRT at the National Cancer Center Hospital, Japan. Of these patients, nine ...
Source: Diseases of the Esophagus - February 26, 2013 Category: Gastroenterology Authors: M. Makazu, K. Kato, H. Takisawa, S. Yoshinaga, I. Oda, Y. Saito, H. Mayahara, Y. Ito, J. Itami, T. Hamaguchi, Y. Yamada, Y. Shimada Tags: Original article Source Type: research

Dosimetric rationale and early experience at UFPTI of thoracic proton therapy and chemotherapy in limited-stage small cell lung cancer.
Conclusion. In this small series of SCLC patients treated with proton therapy with radical intent, treatment was well tolerated with no cases of acute grade 3+ esophagitis or acute grade 2+ pneumonitis. Dosimetric comparison showed better sparing of lung and esophagus with proton therapy. Proton therapy merits further investigation as a method of reducing the toxicity of CRT. PMID: 23438357 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 26, 2013 Category: Cancer & Oncology Authors: Colaco RJ, Huh S, Nichols RC, Morris CG, D'Agostino H, Flampouri S, Li Z, Pham DC, Bajwa AA, Hoppe BS Tags: Acta Oncol Source Type: research

Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice
Upper aerodigestive tract (UADT) cancers of the oral cavity and esophagus are a significant global health burden, and there is an urgent need to develop relevant animal models to identify chemopreventive and therapeutic strategies to combat these diseases. Antizyme (AZ) is a multifunctional negative regulator of cellular polyamine levels, and here, we evaluate the susceptibility of keratin 5 (K5)-AZ transgenic mice to tumor models that combine chemical carcinogenesis with dietary and genetic risk factors known to influence human susceptibility to UADT cancer and promote UADT carcinogenesis in mice. First, p53+/- and K5-AZ/...
Source: Carcinogenesis - February 25, 2013 Category: Cancer & Oncology Authors: Feith, D. J., Pegg, A. E., Fong, L. Y. Y. Tags: Original Manuscript Source Type: research

STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1
The transcription factor signal transducer and activator of transcription 3 (STAT3) contributes to cell proliferation, apoptosis and motility in human cancer cells. We aim to elucidate the function of STAT3 in esophageal carcinogenesis process and molecular mechanisms. We showed that hyperactivated STAT3 in esophageal carcinogenesis tissues correlated with the overexpression of octamer transcription factor-1 (Oct-1). High STAT3 phosphorylation correlated with shorter survival compared with low STAT3 phosphorylation. STAT3 and Oct-1 expression levels affected the proliferation and colony formation of Eca-109 esophageal squa...
Source: Carcinogenesis - February 25, 2013 Category: Cancer & Oncology Authors: Wang, Z., Zhu, S., Shen, M., Liu, J., Wang, M., Li, C., Wang, Y., Deng, A., Mei, Q. Tags: Original Manuscript Source Type: research

Iron chelation: a potential therapeutic strategy in oesophageal cancer
This article is a commentary on Ford et al., pp. 1316–1328 of this issue. To view this paper visit http://dx.doi.org/10.1111/bph.12045 (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - February 25, 2013 Category: Drugs & Pharmacology Authors: BD Keeler, MJ Brookes Tags: Commentary Source Type: research

Ambient Ultraviolet Radiation and Risk of Esophageal CancerAmbient Ultraviolet Radiation and Risk of Esophageal Cancer
Could exposure to ultraviolet radiation predispose some people to esophageal cancer? What does the latest science tell us? The American Journal of Gastroenterology (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - February 24, 2013 Category: Gastroenterology Tags: Gastroenterology Journal Article Source Type: news

Clinical Staging of Early Esophageal Cancer Unreliable
LOS ANGELES (IMNG) - Clinical staging of T2N0 esophageal cancer remains unreliable, despite advances in staging techniques, a study has shown.The addition of endoscopic ultrasound and PET/CT has improved... (Source: OncologySTAT Latest News)
Source: OncologySTAT Latest News - February 22, 2013 Category: Cancer & Oncology Source Type: news

The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas
We examined the expression dynamics of PinX1 by immunohistochemistry in a learning cohort (n = 98) and a validation cohort (n = 59) of ESCC patients treated with definite chemoradiotherapy (CRT). A series of in vivo and in vitro assays were performed to elucidate the effect of PinX1 on ESCC cells' CRT response and underlying mechanisms. Knockdown of PinX1 did not affect ESCC cells' chemosensitivities to 5‐fluorouracil and cisplatin, but substantially increased ESCC cells' therapeutic efficacy of radiation both in vitro and in vivo. Ectopic overexpression of PinX1 dramatically enhanced ESCC cells' resistance to ra...
Source: The Journal of Pathology - February 22, 2013 Category: Pathology Authors: Dong Qian, Bin Zhang, Li‐Ru He, Mu‐Yan Cai, Shi‐Juan Mai, Yi‐Ji Liao, Yan‐Hui Liu, Marie C Lin, Xiu‐Wu Bian, Yi‐Xin Zeng, Jun‐Jian Huang, Hsiang‐Fu Kung, Dan Xie Tags: Original Paper Source Type: research

Overcoming regulatory T‐cell suppression by a lyophilized preparation of Streptococcus pyogenes
Abstract Cancer vaccines have yet to yield clinical benefit, despite the measurable induction of humoral and cellular immune responses. As immunosuppression by CD4+CD25+ regulatory T (Treg) cells has been linked to the failure of cancer immunotherapy, blocking suppression is therefore critical for successful clinical strategies. Here, we addressed whether a lyophilized preparation of Streptococcus pyogenes (OK‐432), which stimulates Toll‐like receptors, could overcome Treg‐cell suppression of CD4+ T‐cell responses in vitro and in vivo. OK‐432 significantly enhanced in vitro proliferation of CD4+ effector T cells ...
Source: European Journal of Immunology - February 22, 2013 Category: Allergy & Immunology Authors: Michiko Hirayama, Hiroyoshi Nishikawa, Yasuhiro Nagata, Takemasa Tsuji, Takuma Kato, Shinichi Kageyama, Shugo Ueda, Daisuke Sugiyama, Sahoko Hori, Shimon Sakaguchi, Gerd Ritter, Lloyd J. Old, Sacha Gnjatic, Hiroshi Shiku Tags: Regular Article Source Type: research

Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes.
Abstract Cancer vaccines have yet to yield clinical benefit, despite the measurable induction of humoral and cellular immune responses. As immunosuppression by CD4(+) CD25(+) regulatory T (Treg) cells has been linked to the failure of cancer immunotherapy, blocking suppression is therefore critical for successful clinical strategies. Here, we addressed whether a lyophilized preparation of Streptococcus pyogenes (OK-432), which stimulates Toll-like receptors, could overcome Treg-cell suppression of CD4(+) T-cell responses in vitro and in vivo. OK-432 significantly enhanced in vitro proliferation of CD4(+) effector T...
Source: European Journal of Immunology - February 22, 2013 Category: Allergy & Immunology Authors: Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old LJ, Gnjatic S, Shiku H Tags: Eur J Immunol Source Type: research

Small cell neuroendocrine carcinoma of the esophagus: report of 6 cases with immunohistochemical and molecular genetic analysis of KIT and PDGFRA.
Abstract Small cell neuroendocrine carcinoma of the esophagus (SCNECE) is a very rare, but a highly aggressive tumor. Six cases of SCNECE (0.25%) were found in the 2,438 archival pathologic specimens of esophagus in the last 20 years in our pathology laboratory. The ages ranged from 62 years to 81 years with a mean of 73 years. All cases were male. The presenting symptoms were dysphagia in 5 cases and vomiting in 1 case. The locations were lower esophagus in 4 cases and middle esophagus in 2 cases. Endoscopically, the tumor was ulcerated in 3 cases and polypoid in 3 cases. All the 6 patients were treated by chemora...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Steroid permeation into the artificial ulcer by combined steroid gel application and balloon dilatation: prevention of esophageal stricture
ConclusionsSteroid gel application is effective way for preventing esophageal stricture after ESD and is more effective compared to local injection in terms of prevention of stricture. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 21, 2013 Category: Gastroenterology Authors: Hirohito Mori, Kazi Rafiq, Hideki Kobara, Shintaro Fujihara, Noriko Nishiyama, Makoto Oryuu, Yasuyuki Suzuki, Tsutomu Masaki Tags: Clinical Hepatology Source Type: research

Utility of Baseline PET/CT for Predicting Endoscopic Resectability and Survival Outcomes in Patients with Early Esophageal Adenocarcinoma
ConclusionsSUVmax ratio (lesion/liver) is more accurate in predicting endoscopic resectability and mortality for EAC than other PET/CT parameters and appears promising as a useful adjunct to the current diagnostic workup. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 21, 2013 Category: Gastroenterology Authors: Gang Sun, Jianmin Tian, Emmanuel C. Gorospe, Geoffrey B. Johnson, Christopher H. Hunt, Lori S. Lutzke, Cadman L. Leggett, Prasad G. Iyer, Kenneth K. Wang Tags: Clinical Gastroenterology Source Type: research

Changing epidemiology of food bolus impaction: Is eosinophilic esophagitis to blame?
ConclusionsThe prevalence of FBI has increased over the last 15 years. This was associated with an increased prevalence of EoE, and, a reduction in age of presentation and peptic‐related strictures. These findings suggest EoE is an important cause of FBI and that esophageal mucosal biopsy should be performed in all cases of FBI. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 21, 2013 Category: Gastroenterology Authors: Venkat N. Mahesh, Richard H. Holloway, Nam Quoc Nguyen Tags: Clinical Gastroenterology Source Type: research

Over-expression of phosphorylated mammalian target of rapamycin is associated with poor survival in oesophageal adenocarcinoma: a tissue microarray study
Conclusion p-mTOR over-expression was detected in 19.7% of patients with OAC and was associated with poor overall survival. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - February 21, 2013 Category: Pathology Authors: Prins, M. J. D., Verhage, R. J. J., Ruurda, J. P., ten Kate, F. J. W., van Hillegersberg, R. Tags: Oesophageal cancer Original article Source Type: research

Preoperative Cetuximab, Irinotecan, Cisplatin, and Radiation Therapy for Patients with Locally Advanced Esophageal Cancer.
Conclusions. This schedule of cetuximab in combination with irinotecan, cisplatin, and radiation therapy was toxic and did not achieve a sufficient pCR rate in patients with localized esophageal adenocarcinoma to undergo further evaluation. PMID: 23429739 [PubMed - as supplied by publisher] (Source: The Oncologist)
Source: The Oncologist - February 21, 2013 Category: Cancer & Oncology Authors: Lee MS, Mamon HJ, Hong TS, Choi NC, Fidias PM, Kwak EL, Meyerhardt JA, Ryan DP, Bueno R, Donahue DM, Jaklitsch MT, Lanuti M, Rattner DW, Fuchs CS, Enzinger PC Tags: Oncologist Source Type: research

The role of aspirin in chemoprevention of oesophageal adenocarcinoma: A meta‐analysis
ConclusionAspirin use confers a significant protective effect against oesophageal adenocarcinoma with a suggestion that the degree of protection may be increased by longer duration and higher frequency usage. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 20, 2013 Category: Gastroenterology Authors: Nishanth Sivarasan, Geoff Smith Tags: Meta Analysis Source Type: research

The Impact of Radiation Therapy Sequencing on Survival and Cardiopulmonary Mortality in the Combined Modality Treatment of Patients with Esophageal Cancer
In a population-based study, investigators further strengthened the evidence that preoperative radiation therapy improved 5-year cause-specific and overall survival in patients with locally advanced esophageal... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - February 20, 2013 Category: Cancer & Oncology Source Type: research

Multiphoton Microscopic Imaging of Esophagus During the Early Phase of Tumor Progression
In this study, we used MPM to image microstructure of human normal esophagus, carcinoma in situ, and early invasive carcinoma in order to investigate the morphological change of tissue structure during the early phase of tumor progression. The diagnostic features such as the appearance of cancerous cells, the absence of the basement membrane were extracted to distinguish between normal and cancerous esophagus tissue. The infiltration depth during tumor progression was determined by the appearance of cancerous cells. The significant change of layer structure between cancerous tissue and normal esophagus was described. We al...
Source: Scanning - February 20, 2013 Category: Radiology Authors: Jian Xu, Deyong Kang, Meifang Xu, Shuangmu Zhuo, Xiaoqin Zhu, Jianxin Chen Tags: Original Article Source Type: research

Synchronous cancers in patients with head and neck cancer
CONCLUSIONS:The current data are consistent with the etiologic shift of oropharyngeal HNSCC, from a primarily tobacco‐associated malignancy associated with significant field cancerization of the upper aerodigestive mucosa, to a malignancy primarily caused by oncogenic human papillomavirus. Cancer 2013;. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - February 19, 2013 Category: Cancer & Oncology Authors: Kunal S. Jain, Andrew G. Sikora, Shrujal S. Baxi, Luc G. T. Morris Tags: Original Article Source Type: research

Robot‐Assisted Thoracoscopic Hybrid Esophagectomy in the Semi‐Prone Position Under Pneumothorax
Abstract We performed robot‐assisted thoracoscopic hybrid esophagectomy using the da Vinci Surgical System and demonstrated the potential benefit of this minimally invasive lymphadenectomy. Between April 2010 and October 2011, four patients with intrathoracic esophageal cancer underwent hybrid esophagectomy in the semi‐prone position using a 3‐arm standard da Vinci and a conventional thoracoscopic maneuver. All thoracoscopic procedures were completed using a robot‐assisted technique. Robot‐assisted thoracoscopic esophagectomy in the semi‐prone position is safe and technically feasible. A hybrid procedure that c...
Source: Artificial Organs - February 18, 2013 Category: Transplant Surgery Authors: Norihiko Ishikawa, Masahiko Kawaguchi, Noriyuki Inaki, Hideki Moriyama, Masanari Shimada, Go Watanabe Tags: Thoughts and Progress Source Type: research

Alcohol Plays A Huge Role In Cancer Deaths In The U.S.
We have known for years that sun exposure can lead to skin cancer and smoking can lead to lung cancer. Now a new report reveals that drinking alcohol is responsible for 3.5 percent of all cancer deaths in the U.S. The findings, published in the American Journal of Public Health, outline the cancer risks linked to alcohol use. This is the first major examination of this topic in over 30 years. The researchers analyzed cancers of the: rectum colon esophagus liver female breast larynx pharynx mouth The investigators examined surveys, 2009 U... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 16, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Tumor texture analysis has prognostic potential
Tumor texture analysis, determined by computed tomography, holds promise as a prognostic biomarker in patients with esophageal cancer, research indicates. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - February 16, 2013 Category: Cancer & Oncology Source Type: news

A meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma
Conclusion Overweight and obesity are strongly related to EGCA, particularly to espophageal adenocarcinoma. (Source: Annals of Oncology)
Source: Annals of Oncology - February 16, 2013 Category: Cancer & Oncology Authors: Turati, F., Tramacere, I., La Vecchia, C., Negri, E. Tags: reviews Source Type: research

Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety report
Conclusions Addition of bevacizumab to peri-operative ECX chemotherapy is feasible with acceptable toxicity and no negative impact on surgical outcomes. (Source: Annals of Oncology)
Source: Annals of Oncology - February 16, 2013 Category: Cancer & Oncology Authors: Okines, A. F. C., Langley, R. E., Thompson, L. C., Stenning, S. P., Stevenson, L., Falk, S., Seymour, M., Coxon, F., Middleton, G. W., Smith, D., Evans, L., Slater, S., Waters, J., Ford, D., Hall, M., Iveson, T. J., Petty, R. D., Plummer, C., Allum, W. H. Tags: gastrointestinal tumors Source Type: research

Phase II randomized, double-blind, placebo-controlled study of AMG 386 (trebananib) in combination with cisplatin and capecitabine in patients with metastatic gastro-oesophageal cancer
Conclusions In this study, PFS and ORR were estimated to be similar with AMG 386 plus CX and placebo plus CX treatment. Compared with placebo, toxicity of AMG 386 plus CX was greater but manageable. Previous presentation The results of this study have not been previously published or submitted for publication elsewhere. The results were presented in part at the Gastrointestinal Cancers Symposium, San Francisco, CA, January 20–22, 2011. Clinical trial registration ClinicalTrials.gov registration number: NCT00583674 (Source: Annals of Oncology)
Source: Annals of Oncology - February 16, 2013 Category: Cancer & Oncology Authors: Eatock, M. M., Tebbutt, N. C., Bampton, C. L., Strickland, A. H., Valladares-Ayerbes, M., Swieboda-Sadlej, A., Van Cutsem, E., Nanayakkara, N., Sun, Y.- N., Zhong, Z. D., Bass, M. B., Adewoye, A. H., Bodoky, G. Tags: gastrointestinal tumors Source Type: research

More information about the pattern of lymphatic spread could improve the effectiveness of surgery for esophageal cancer
We read with interest the article by Li and colleagues recently published in the Journal. They investigated the distribution of lymph node metastasis in thoracic esophageal squamous cell carcinoma. This is an important topic because several articles have shown the relation between nodal involvement and worse prognosis of these patients. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - February 15, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Francesco Cavallin, Marco Scarpa, Carlo Castoro Tags: Letters to the Editor Source Type: research

Reply to the Editor
We thank Cavallin and colleagues for their interest in our article. Although controversies still remain in the management of esophageal cancer, and neoadjuvant therapy has not been widely conducted in China, it is obvious that neoadjuvant therapy plays an important role. Over the past decade, treatment strategy has changed a lot in our center. Between 2000 and 2004, the McKeown procedure with a 3-field lymphadenectomy was performed unselectively to all patients with esophageal cancer. Since 2005, Ivor-Lewis esophagectomy with 2-field lymphadenectomy has been widely performed, and the 3-field lymphadenectomy procedure was ...
Source: The Journal of Thoracic and Cardiovascular Surgery - February 15, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Bin Li, Haiquan Chen Tags: Letters to the Editor Source Type: research

Barrett's Esophagus: Endoluminal Therapy Safe, Effective Barrett's Esophagus: Endoluminal Therapy Safe, Effective
Endoluminal therapy that combines endoscopic mucosal resection and ablation is successful long-term in patients with Barrett's esophagus and high-grade dysplasia or intramucosal carcinoma. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 15, 2013 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Long-Term Success Rates Shown For Eradication Of Barrett's Esophagus After Endoluminal Therapies
A new study from researchers at the Hospital of the University of Pennsylvania reports that endoluminal (endoscopic) therapies, combining resection and ablation techniques, for patients with Barrett's esophagus and high-grade dysplasia or early mucosal cancer have a high success rate, with durable results and a low risk of complications. The researchers noted that endoscopic surveillance after successful eradication is required... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 15, 2013 Category: Consumer Health News Tags: Acid Reflux / GERD Source Type: news

The role of endoscopy in the assessment and treatment of esophageal cancer
This is one of a series of statements discussing the use of GI endoscopy in common clinical situations. The Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy (ASGE) prepared this text. This guideline updates a previously issued guideline on this topic. In preparing this guideline, a search of the medical literature was performed by using PubMed. Additional references were obtained from the bibliographies of the identified articles and from recommendations of expert consultants. When few or no data exist from well-designed prospective trials, emphasis is given to results from large serie...
Source: Gastrointestinal Endoscopy - February 15, 2013 Category: Gastroenterology Authors: John A. Evans, Dayna S. Early, Vinay Chandraskhara, Krishnavel V. Chathadi, Robert D. Fanelli, Deborah A. Fisher, Kimberly Q. Foley, Joo Ha Hwang, Terry L. Jue, Shabana F. Pasha, Ravi Sharaf, Amandeep K. Shergill, Jason A. Dominitz, Brooks D. Cash, ASGE S Tags: Guideline Source Type: research

Does Sex Affect Survival of Patients With Squamous Cell Esophageal Cancer? [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 15, 2013 Category: Cancer & Oncology Authors: Zhang, Garfield, Jiang, Wang, Chen, Chen Tags: CORRESPONDENCE Source Type: research

Upregulation of HO-1 is accompanied by activation of p38MAPK and mTOR in human esophageal squamous carcinoma cells.
Abstract Induction of HO-1 protein can have both beneficial and detrimental effects for cells, including regulating proliferation and apoptosis of several tumors. We have investigated the regulation of HO-1, p38MAPK and mTOR in the context of proliferation, cell cycle events and apoptosis of esophageal squamous cell carcinoma cells. Real-time PCR and western blots were used to determine the expression levels of HO-1, p38MAPK, p-p38MAPK and p-mTOR. MTT assays were used to measure proliferation, FACS for cell cycle events, and Annexin V staining for apoptosis. Proliferation of Eca109 cells was inhibited and apoptosis...
Source: Cell Biology International - February 15, 2013 Category: Cytology Authors: Hu JL, Xiao L, Li ZY, Wang Q, Chang Y, Jin Y Tags: Cell Biol Int Source Type: research

Study: Alcohol Is Leading Preventable Cause Of Cancer In U.S.
BOSTON (CBS) – Researchers in Boston have taken a good hard look at alcohol and cancer deaths. Dr. Timothy Naimi, at Boston University School of Medicine, says this is the first time in 30 years that researchers have looked closely at alcohol and cancer deaths. WBZ NewsRadio 1030′s Diane Stern reports Download: alcohol-cancer-doc-web-extended.mp3 “When it comes to alcohol consumption and cancers, clearly excessive drinking is the riskiest type of drinking,” Dr. Naimi said. “But when it comes to cancer, there is no safe level of alcohol consumption.” Res...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 14, 2013 Category: Consumer Health News Authors: deanreddington Tags: Health Heard On WBZ NewsRadio 1030 Sports Syndicated Local Watch Listen Alcohol alcohol cancer Boston University School Of Medicine Diane Stern Dr. Timothy Naimi Source Type: news

The multiple roles for Sox2 in stem cell maintenance and tumorigenesis.
Abstract The Sry-containing protein Sox2 initially was known to regulate the self-renewal of the mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of stem cells in multiple adult tissues including the brain and trachea, and it is one of the key transcription factors for establishing induced pluripotent stem cells. Recently, overexpression and gene amplification of Sox2 has been associated with the development of squamous cell carcinoma in multiple tissues such as the lung and esophagus. These different roles for Sox2 involve a complicated regulatory networks consisting of microRN...
Source: Cellular Signalling - February 14, 2013 Category: Cytology Authors: Liu K, Lin B, Zhao M, Yang X, Chen M, Gao A, Liu F, Que J, Lan X Tags: Cell Signal Source Type: research

Opium: An emerging risk factor for gastric adenocarcinoma
Opium use has been associated with higher risk of cancers of the esophagus, bladder, larynx, and lung; however, no previous study has examined its association with gastric cancer. There is also little information on the associations between hookah (water pipe) smoking or the chewing of tobacco products and the risk of gastric cancer. In a case‐control study in Golestan Province of Iran, we enrolled 309 cases of gastric adenocarcinoma (118 noncardia, 161 cardia and 30 mixed‐location adenocarcinomas) and 613 matched controls. Detailed information on long‐term use of opium, tobacco products and other covariates were col...
Source: International Journal of Cancer - February 13, 2013 Category: Cancer & Oncology Authors: Ramin Shakeri, Reza Malekzadeh, Arash Etemadi, Dariush Nasrollahzadeh, Karim Aghcheli, Masoud Sotoudeh, Farhad Islami, Akram Pourshams, Michael Pawlita, Paolo Boffetta, Sanford M. Dawsey, Christian C. Abnet, Farin Kamangar Tags: Epidemiology Source Type: research

[Barrett's syndrome and esophageal adenocarcinoma.]
PMID: 23400764 [PubMed - as supplied by publisher] (Source: Der Chirurg)
Source: Der Chirurg - February 13, 2013 Category: Surgery Authors: Blömer M, Jähne J Tags: Chirurg Source Type: research

CT Texture Analysis Of Tumors May Be A Valuable Biomarker In Localized Esophageal Cancer
CT texture analysis of primary tumors may be a potential imaging biomarker in localized esophageal cancer following neoadjuvant chemotherapy, according to research presented at the 2013 Cancer Imaging and Radiation Therapy Symposium. This Symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North American (RSNA)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 12, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Tumoral Texture Features May Be A Valuable Biomarker In Localized Esophageal Cancer
CT texture analysis of primary tumors may be a potential imaging biomarker in localized esophageal cancer following neoadjuvant chemotherapy, according to research presented at the 2013 Cancer Imaging and Radiation Therapy Symposium. This Symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North American (RSNA)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 12, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Study shows long-term success rates for eradication of Barrett's esophagus after endoluminal therapies
(American Society for Gastrointestinal Endoscopy) A new study from researchers at the Hospital of the University of Pennsylvania reports that endoluminal (endoscopic) therapies, combining resection and ablation techniques, for patients with Barrett's esophagus and high-grade dysplasia or early mucosal cancer have a high success rate, with durable results and a low risk of complications. The researchers noted that endoscopic surveillance after successful eradication is required. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 12, 2013 Category: Global & Universal Source Type: news

Some Reassurance About Proton Pump Inhibitors and Risk of Osteoporotic Fractures
Despite limitations, this study lends some reassurance that risk of osteoporosis is not likely to overshadow the benefit of proton pump inhibitors in preventing recurrent peptic ulcer, esophageal reflux symptoms, and esophageal cancer risk. (Source: Consultant Live)
Source: Consultant Live - February 11, 2013 Category: Primary Care Source Type: news

Non-malignant respiratory tract fistula from the oesophagus. A lethal condition for which novel therapeutic options are emerging
CONCLUSIONS When an oesophago-respiratory fistula is diagnosed, even in a situation where no neoplastic tissue is prevailing, attempts should be made to close the fistula tract by SEMS from both directions, i.e. from the oesophageal as well as the respiratory side. By this means, a majority of these patients can be initially managed conservatively with prospects of a successful outcome, although virtually all will eventually require a single-stage resection and reconstruction. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - February 11, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Elbe, P., Lindblad, M., Tsai, J., Juto, J.-E., Henriksson, G., Agustsson, T., Lundell, L., Nilsson, M. Tags: Thoracic Source Type: research

Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment
arling, Laurie E Ailles, Hala El-Zimaity & Geoffrey Liu (Source: Laboratory Investigation AOP)
Source: Laboratory Investigation AOP - February 11, 2013 Category: Laboratory Medicine Authors: Lorin DodbibaJennifer TeichmanAndrew FleetHenry ThaiBin SunDevang PanchalDevalben PatelAlvina TseZhuo ChenOlusola O FaluyiDaniel J RenoufHala GirgisBizhan BandarchiJoerg SchwockWei XuRobert G BristowMing-Sound TsaoGail E DarlingLaurie E AillesHala El-Zima Tags: adenocarcinoma clinicopathological features engraftment esophageal cancer GE-Junction primary xenograft squamous cell carcinoma. Source Type: research