Kidney Transplant This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Factors associated with glucose metabolism disorders after kidney transplantation.
CONCLUSIONS: We found a high prevalence of glucose metabolism disorders in the examined group. This suggests that kidney transplant recipients should be screened for these disturbances. Patients with higher BMI and with first-degree relatives with diabetes had an increased risk of glucose metabolism disorders after kidney transplantation. PMID: 23450443 [PubMed - indexed for MEDLINE] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - May 24, 2013 Category: Endocrinology Authors: Brzezińska B, Junik R, Kamińska A, Włodarczyk Z, Adamowicz A Tags: Endokrynol Pol Source Type: research

[Correspondence] Balancing effectiveness and equality of opportunity in organ allocation
Dominic Summers and colleagues' (March 2, p 727) analysis of UK transplant registry data shows that recipients of kidneys from all deceased donors aged older than 60 years have more than twice the risk of graft failure than those from donors younger than 40 years. However, kidneys from older (>60 years) controlled circulatory-death donors (cDCDs) have equivalent 3-year graft survival to those from brain-death donors (DBDs) in the same age group, suggesting that reluctance to use these organs is unjustified. (Source: LANCET)
Source: LANCET - May 24, 2013 Category: Journals (General) Authors: Antonia Cronin, James Douglas Tags: Correspondence Source Type: research

[Preoperative evaluation of the body concept of donors and recipients of living kidney donations].
CONCLUSION: The psychological coping process involved in living kidney donation demands a reconstitution of the body self. The coping/health behavior and the affective state of living kidney recipients are protective factors that influence successful organ integration. PMID: 23467994 [PubMed - in process] (Source: Zeitschrift fur Psychosomatische Medizin und Psychotherapie)
Source: Zeitschrift fur Psychosomatische Medizin und Psychotherapie - May 24, 2013 Category: Psychiatry Authors: Kumnig M, Beck T, Höfer S, König P, Schneeberger S, Weißenbacher A, Bunzel B, Schüßler G, Rumpold G Tags: Z Psychosom Med Psychother Source Type: research

Bullous pemphigoid associated with chronic renal allograft rejection
We report a case of bullous pemphigoid (BP) in a young woman who presented with chronic renal allograft rejection, an unusual association. A 15-year-old girl developed nephrotic syndrome as a result of mesangial glomerulonephritis. She developed loss of renal function, requiring dialysis, and underwent kidney transplantation 3 years later. Ten years after the transplantation, she again presented with renal function impairment. A kidney biopsy specimen demonstrated chronic rejection, and she was again submitted to dialysis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 24, 2013 Category: Dermatology Authors: Juliano Peruzzo, Lia Dias Pinheiro Dantas, Marcia Zampese Tags: JAAD Online Source Type: research

Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells.
Abstract High-level polyomavirus BK (BKPyV) replication in urothelial cells is a hallmark of polyomavirus-associated hemorrhagic cystitis (PyVHC), a painful condition affecting bone marrow transplant recipients. In kidney transplant recipients, replication in tubular epithelial cells is associated with overt disease whereas high-level urothelial replication is clinically silent. We characterized BKPyV replication in primary human urothelial cells (HUCs) and compared it to replication in renal tubular epithelial cells (RPTECs). HUCs were easily infected, as shown by expression of T-antigens, VP1-3, and agnoprotein, ...
Source: Virology - May 23, 2013 Category: Virology Authors: Li R, Sharma BN, Linder S, Gutteberg TJ, Hirsch HH, Rinaldo CH Tags: Virology Source Type: research

Results of pretransplant treatment of hepatorenal syndrome with terlipressin.
Abstract PURPOSE OF REVIEW: Hepatorenal syndrome (HRS) is a dreaded complication of end-stage liver disease. The best treatment option for HRS is liver transplantation (LT) in suitable candidates. Pretransplant care of HRS is of utmost importance in order to secure a good posttransplant outcome. We review the advances during the last year in the diagnosis and management of HRS in candidates who are awaiting liver transplantation. RECENT FINDINGS: New attempts at defining renal failure in cirrhosis using the Acute Kidney Injury (AKI) definition have been proposed, as this definition has the potential advantage o...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: Solà E, Cárdenas A, Ginès P Tags: Curr Opin Organ Transplant Source Type: research

Renal allograft pathology in the sensitized patient.
Abstract PURPOSE OF REVIEW: Patterns of renal allograft injury associated with alloantibody have been increasingly recognized over the past 2 decades. The use of more sensitive serum testing has brought to light the range of alloantibody-associated changes on biopsy at different time points posttransplant. There is likely to be an increasing number of patients with preformed alloantibody undergoing kidney transplantation, and so alloantibody-associated injury will become more prevalent. RECENT FINDINGS: Acute antibody-mediated rejection (AMR) is a major complication in kidney transplant patients with preformed ...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: Cornell LD Tags: Curr Opin Organ Transplant Source Type: research

Pathology of recurrent diseases in kidney allografts: membranous nephropathy and focal segmental glomerulosclerosis.
Abstract PURPOSE OF REVIEW: Glomerulonephritis is the leading cause of end-stage renal failure in renal transplant recipients. Recurrence of diseases in kidney allograft provides a unique opportunity to study the mechanisms of kidney disorders leading to the underlying native organ failure. There have been new advances in the understanding of the mechanisms of membranous nephropathy and focal segmental glomerulosclerosis (FSGS). RECENT FINDINGS: Recent studies of recurrent membranous nephropathy provide evidence of the presence of circulating recipient factor that targets the donor kidney and put forward the ev...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: Kowalewska J Tags: Curr Opin Organ Transplant Source Type: research

Pancreas transplantation, antibodies and rejection: where do we stand?
Abstract PURPOSE OF REVIEW: Antibody-mediated rejection (AMR) is acknowledged and defined in kidney transplantation, but where do we stand as far as pancreas transplantation is concerned? Here we appraise the most recent findings in pancreatic AMR and give suggestions for future research in the field by addressing currently unresolved issues. RECENT FINDINGS: Five main topics are discussed: chronological assessment of all literature on biopsy-proven pancreatic AMR; role of C4d and recent development in other markers; the use of sentinel organs, such as kidney biopsies and duodenal patch biopsies for diagnosis o...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: de Kort H, Roufosse C, Bajema IM, Drachenberg CB Tags: Curr Opin Organ Transplant Source Type: research

Impact of donor-specific antibodies on results of liver transplantation.
Abstract PURPOSE OF REVIEW: To critically examine the recent literature evaluating the importance of HLA donor-specific antibody (DSA) impact on liver transplant and simultaneous liver-kidney transplant (SLKT) outcomes. RECENT FINDINGS: Many preformed DSAs, especially of low mean fluorescence intensity (MFI), are absorbed by the liver at transplant. However, patients with post-liver transplant DSA, especially of higher MFI, are at increased risk of acute and chronic rejection. C4d staining, when positive, may be helpful but lacks sensitivity especially in formalin tissue. SLKT recipients may need close follow-u...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: O'Leary JG, Klintmalm GB Tags: Curr Opin Organ Transplant Source Type: research

Assessment of donor biopsies.
Abstract PURPOSE OF REVIEW: To provide an up-to-date overview about the assessment of donor biopsies and to discuss the current problems and chances of preimplantation biopsies for transplant allocation with a focus on the technical work up and the histological variables scored. RECENT FINDINGS: Preimplantation biopsy results are the major reason for discarding procured extended donor criteria kidneys in the USA. There is neither a consensus on the work up, nor the reporting of preimplantation donor biopsies, nor the importance of the biopsy findings in the process of allocation. The best available data have be...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: Hopfer H, Kemény E Tags: Curr Opin Organ Transplant Source Type: research

Researchers Hope To Recycle Kidneys To Help solve Donor Organ shortage
Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too long without blood or oxygen... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 23, 2013 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

Optimising utilisation of kidneys from deceased donors over 60 years: Five–year outcomes after implementation of a combined clinical and histological allocation algorithm
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 22, 2013 Category: Transplant Surgery Authors: E S Pierobon, S Sandrini, N Fazio, G Rossini, I Fontana, I Boschiero, M Gropuzzo, E Gotti, D Donati, E Minetti, M T Gandolfo, A Brunello, C Libetta, A Secchi, S Chiaramonte, P Rigotti Tags: Original Article Source Type: research

Chronic lithium treatment protects against liver ischemia‐reperfusion injury in rats
In this study, we aimed to evaluate the effects of lithium in a model of liver ischemia/reperfusion injury (I/R) in rats. Chronic treatment with lithium (2 mmol/kg, for 3 days before ischemia) decreased I/R injury, whereas acute treatment with a single dose of lithium (2 mmol/kg, 1 h before ischemia) did not confer any protection in partial hepatic I/R model. Furthermore, chronic lithium‐treated rats had a significantly better survival rate (60%) as compared to saline (27%) in total hepatic I/R survival model. Chronic lithium treatment protected against liver I/R injury, as indicated by lower serum aminotransferase level...
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Anding Liu, Haoshu Fang, Uta Dahmen, Olaf Dirsch Tags: Original Article Source Type: research

Carbon monoxide exposure improves immune function in lupus prone mice.
This article is protected by copyright. All rights reserved. PMID: 23691924 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 21, 2013 Category: Allergy & Immunology Authors: Mackern-Oberti JP, Llanos C, Carreño LJ, Riquelme SA, Jacobelli SH, Anegon I, Kalergis AM Tags: Immunology Source Type: research

Quiz Page JUNE 2013: Graft Dysfunction After Kidney Transplantation in an Adolescent
A 15-year-old boy with no relevant medical or family history presented with nausea and fatigue. His blood pressure was 150/90 mm Hg, but the rest of the physical examination findings were normal. Laboratory investigations showed the following values: serum creatinine, 18.9 mg/dL (estimated glomerular filtration rate [GFR], 5 mL/min/1.73 m2 by the modified Schwartz formula); serum urea nitrogen, 549 mg/dL; parathyroid hormone, 496 (reference range, 9-55) pg/mL; and hemoglobin, 9.0 g/dL. Urinalysis showed hematuria (1+) and proteinuria (protein excretion, 930 mg/24 h), with occasional red blood cells on sediment evaluation. ...
Source: American Journal of Kidney Diseases - May 20, 2013 Category: Urology & Nephrology Authors: Badria Al Ghaithi, Siew-Le Chong, Reham Al Mardini, Seetha Radhakrishnan, Rohan John, Lisa A. Robinson Source Type: research

Study suggests new source of kidneys for transplant
(Wake Forest Baptist Medical Center) Nearly 20 percent of kidneys that are recovered from deceased donors in the US are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too long without blood or oxygen. But, what if instead of being discarded, these organs could be "recycled" to help solve the critical shortage of donor organs? (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 20, 2013 Category: Global & Universal Source Type: news

Immunogenicity of pandemic influenza A H1N1/2009 adjuvanted vaccine in pediatric solid organ transplant recipients
Abstract The aim of this study was to assess the immunogenicity of a vaccine against this virus in a prospective cohort of transplanted pediatric patients without previous influenza infection who received one dose of MF59®‐adjuvanted pandemic H1N1/2009 vaccine. Seventeen patients who were being regularly followed up at the Outpatient Clinic of the Children's Transplant Unit (liver and kidney transplantation) in Hospital Universitari Vall d′Hebron (Barcelona) were included. Seroconversion was demonstrated in 15 of 17 (88.2%) vaccinated children. There were no rejection episodes or major adverse events. The MF59®‐adj...
Source: Pediatric Transplantation - May 20, 2013 Category: Transplant Surgery Authors: J. Gavaldà, E. Cabral, P. Perez‐Romero, O. Len, T. Aydillo, M. Campins, J. Quintero, M. Peghin, J. Nieto, R. Charco, A. Pahissa, E. Cordero, Tags: Original Article Source Type: research

Immune function assay (ImmuKnow) as a predictor of allograft rejection and infection in kidney transplantation
ConclusionsThe IK assay combined with other biomarkers can be used to identify kidney transplant patients at high risk of rejection and infection. (Source: Clinical Transplantation)
Source: Clinical Transplantation - May 20, 2013 Category: Transplant Surgery Authors: Jun He, Yang Li, Hui Zhang, Xudong Wei, Hao Zheng, Chao Xu, Xiaojing Bao, Xiaoni Yuan, Jianquan Hou Tags: Original Article Source Type: research

Msc and kidney transplantation: Pre‐transplant infusion protects from graft dysfunction While fostering immunoregulation
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: Norberto Perico, Federica Casiraghi, Eliana Gotti, Martino Introna, Marta Todeschini, Regiane Aparecida Cavinato, Chiara Capelli, Alessandro Rambaldi, Paola Cassis, Paola Rizzo, Monica Cortinovis, Marina Noris, Giuseppe Remuzzi Tags: Original Article Source Type: research

Clinical and microbial impact of screening kidney allograft preservative solution for bacterial contamination with high sensitivity methods
In conclusion, the use of more sensitive culture methods increases the rate of bacterial contamination of PS and is associated with an increased prescription of antibiotics and increased ESBL‐PE carriage and related infections. Therefore, the systematic use of PS blood bottle cultures in kidney transplantation may have no benefit and might increase the rate of ESBL‐PE emergence. This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: Dominique Bertrand, Nicolas Pallet, Albane Sartorius, Jean Ralph Zahar, Rebecca Sberro Soussan, Olivier Lortholary, Christophe Legendre, Marie‐France Mamzer Tags: Original Article Source Type: research

Systematic Review of Mouse Kidney Transplantation
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: George Hondag Tse, Jeremy Hughes, Lorna Palmer Marson Tags: Review Article Source Type: research

Posttransplant monitoring of de-novo human leukocyte antigen donor-specific antibodies in kidney transplantation.
Abstract PURPOSE OF THE REVIEW: To summarize the evidence supporting the negative impact of de-novo donor-specific antibodies (dnDSA) in renal transplantation and to describe the natural history associated with the development of dnDSA. RECENT FINDINGS: Recent studies have increased our appreciation of the risk factors that predispose to dnDSA while illuminating how these risk factors may relate to the pathophysiology underlying its development. In addition, details regarding the natural history of dnDSA are now available in the context of the different clinical pathologic phenotypes that occur in the patients in w...
Source: Current Opinion in Organ Transplantation - May 20, 2013 Category: Transplant Surgery Authors: Wiebe C, Nickerson P Tags: Curr Opin Organ Transplant Source Type: research

How do kidney exchanges work?
Many people in need of kidney transplants have family members or loved ones who are willing to donate a kidney. However, willing donors often aren't matches. Kidney exchanges allow people who need transplants but have an incompatible donor to pair with families with the same problem and exchange kidneys. According to Sommer Gentry, Ph.D., kidney exchanges can be done between two families or can be.... (Source: Sound Medicine)
Source: Sound Medicine - May 19, 2013 Category: Global & Universal Authors: Sound Medicine Source Type: news

The effect of rabbit antithymocyte globulin on human mesenchymal stem cells
Summary Mesenchymal stem cells (MSCs) possess immunomodulatory properties which are of key interest for their application in autoimmunity and transplantation. In transplantation, administration of MSCs has shown promising results in preclinical models and has recently moved to clinical trials. Therefore, it is important to study the interactions between MSCs and immunosuppressive drugs currently used in transplantation. We aimed to analyze the effect of rabbit antithymocyte globulin (rATG) MSCs. MSCs were obtained from perirenal fat of kidney donors and exposed to ranging doses of rATG (Thymoglobulin®, Genzyme; 0.5–100�...
Source: Transplant International - May 19, 2013 Category: Transplant Surgery Authors: Marcella Franquesa, Carla C. Baan, Sander S. Korevaar, Anja U. Engela, Marieke Roemeling‐van Rhijn, Willem Weimar, Michiel G. H. Betjes, Josep M. Grinyo, Martin J. Hoogduijn Tags: Original Article Source Type: research

Exploring the views of patients not on the transplant waiting list: a qualitative study
ConclusionsPatients trust their carers and support an efficacy argument when considering scarce resources. Communication should be improved to ensure clarity and understanding of clinical decisions. (Source: Journal of Renal Care)
Source: Journal of Renal Care - May 18, 2013 Category: Urology & Nephrology Authors: Christopher Lawrence, Shivani Sharma, Maria Da Silva‐Gane, Ben C. Fletcher, Ken Farrington Tags: ORIGINAL RESEARCH Source Type: research

Robotic Kidney Transplants May Be Best Option For Obese Patients
Obese patients who received robotic kidney transplants had fewer wound complications than patients who received traditional "open" transplant surgery, according to surgeons at the University of Illinois Hospital & Health Sciences System. The findings should allow more obese patients to receive kidney transplants. Patients with a body mass index (BMI) greater than 35 who have end-stage kidney disease are often denied transplantation, and patients with a BMI over 40 often die on dialysis without an opportunity for transplant... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

Incidence and prevalence of cancer in kidney transplantation waiting list patients: An italian experience.
Conclusion: Kidney transplant waiting list patients present a higher incidence and prevalence of cancer compared to general population; it could be important to evaluate them for ESKD related malignancies because of their high incidence. PMID: 23504812 [PubMed - in process] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - May 17, 2013 Category: Transplant Surgery Authors: Mosconi G, Centofanti F, Capelli I, Ricci A, Persici E, Gandolfini I, Rubbiani E, Buzio C, Cappelli G, Costa AN, Stefoni S Tags: Int J Artif Organs Source Type: research

Antiviral therapy of symptomatic HCV-mixed  cryoglobulinemia after liver transplant: Case  report and literature review.
We report on a 48-year-old man who developed HCV-associated cryoglobulinemic vasculitis with recurrent hepatitis after liver transplant. One year after transplant for HCV-positive  cirrhosis, he presented severe cutaneous manifestations, and biopsy-proven cryoglobulinemic membrano-proliferative glomerulonephritis (MPGN). HCV RNA clearance occurred within a few weeks of antiviral therapy; sustained viral response (SVR) was obtained by one year of anti-HCV combination therapy (eight months of pegylated IFN/ribavirin and four months of standard IFN/ribavirin). SVR was linked to complete remission of skin, liver, and kidney ...
Source: The International Journal of Artificial Organs - May 17, 2013 Category: Transplant Surgery Authors: Francesca Donato M, Banfi G, Cresseri D, Battista Fogazzi G, Martin P, Messa P, Fabrizi F Tags: Int J Artif Organs Source Type: research

Robotic transplant an option for obese kidney patients
(University of Illinois at Chicago) Robotic kidney transplantation gives new hope to obese patients previously denied access to life-saving surgery. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2013 Category: Global & Universal Source Type: news

Four‐year allograft survival in a highly sensitized combined liver–kidney transplant patient despite unsuccessful anti‐HLA antibody reduction with rituximab, splenectomy, and bortezomib
Summary Although donor‐specific lymphocytotoxic antibodies are regarded as a contraindication for kidney transplantation (KTx), the data available for liver or combined liver or kidney transplantation (cLKTx) are scarce. Here, we report a case of a highly sensitized young man receiving his sixth liver and second kidney graft. Multiple anti‐HLA antibodies were present at the time of transplantation. As a result of suspected antibody‐mediated graft damage, the patient was treated with rituximab, plasmapheresis, intravenous immunoglobulins, splenectomy, and bortezomib to decrease the antibody production. So far, patient...
Source: Transplant International - May 15, 2013 Category: Transplant Surgery Authors: Martina Koch, Christian Gräser, Anja Lehnhardt, Jörg M. Pollok, Nikolaus Kröger, Murielle Verboom, Friedrich Thaiss, Thomas Eiermann, Björn Nashan Tags: Case Report Source Type: research

Increased incidence of herpes zoster in the setting of cytomegalovirus preemptive therapy after kidney transplantation
ConclusionsIn the setting of CMV preemptive therapy, a differentiated varicella zoster virus‐specific prophylaxis might be necessary for patients with HZ risk factors. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - May 15, 2013 Category: Transplant Surgery Authors: G.B. Ko, T. Kim, S.‐H. Kim, S.‐H. Choi, Y.S. Kim, J.H. Woo, Y.H. Kim, J.B. Park, S.K. Lee, S.‐K. Park, J.S. Park, D.J. Han, S.‐O. Lee Tags: Original Article Source Type: research

Impaired thymic function and CD4+ T lymphopenia, but not mannose-binding lectin deficiency are risk factors for pneumocystis jirovecii pneumonia in kidney transplant recipients.
In conclusion, PCP risk was associated with higher age and related to both thymic functional impairment and long-lasting CD4+ T-lymphopenia starting already before transplantation. Despite frequent occurrence in KTR, low levels of serum MBL were not associated with increased risk for PCP. CD4+ T-cell counts and function should be addressed in prospective studies for more individualized approaches to PCP prophylaxis. PMID: 23684946 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
Source: Transplant Immunology - May 15, 2013 Category: Transplant Surgery Authors: Schürmann M, Schürmann D, Schindler R, Meisel C, Liman P, Kruse J, Enghard P, König J, Schmidt D, Reinke P, Nickel P Tags: Transpl Immunol Source Type: research

Probability of deceased donor kidney transplantation based on % PRA.
CONCLUSIONS: The probability of receiving a DD kidney transplant is inversely related to the % PRA although a higher risk for not receiving a KT becomes evident with a PRA >20%. PMID: 23684945 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
Source: Transplant Immunology - May 15, 2013 Category: Transplant Surgery Authors: Bostock IC, Alberú J, Arvizu A, Hernández-Mendez EA, De-Santiago A, González-Tableros N, López M, Castelán N, Contreras AG, Morales-Buenrostro LE, Gabilondo B, Vilatobá M Tags: Transpl Immunol Source Type: research

Changing transplant recipient education and inpatient transplant pharmacy practices: A single-center perspective.
CONCLUSION: The participation of pharmacists on the kidney transplant team enhanced a hospital's medication management, discharge planning, and patient education services for transplant recipients, helping to reduce their average LOS and yielding substantial cost savings. PMID: 23640352 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - May 15, 2013 Category: Drugs & Pharmacology Authors: Maldonado AQ, Weeks DL, Bitterman AN, McCleary JA, Seiger TC, Carson RW, Tabon PK, Goroski AL, Ojogho ON Tags: Am J Health Syst Pharm Source Type: research

Star Career Academy Students Support Classmate With Long Island Kidney Walk Sponsorship
Star Career Academy students from the school's Long Island campus, will honor classmate Megan Reister, who had a failed kidney transplant at the age of 15 and family members who have survived kidney cancer...05/14/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - May 14, 2013 Category: Cancer & Oncology Source Type: news

Biomarkers for acute kidney injury: combining the new silver with the old gold
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Macedo, E., Mehta, R. L. Tags: IN FOCUS Source Type: research

Detection and progression of chronic kidney disease: does the rear-view mirror help?
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: McMahon, L. P. Tags: IN FOCUS Source Type: research

Vascular calcification--is aldosterone a culprit?
In chronic kidney disease (CKD), increased plasma phosphate concentrations cause vascular calcification which substantially contribute to cardiovascular events and increased mortality of CKD patients. Similar to CKD patients, klotho-hypomorphic mice (kl/kl) also suffer from excessive vascular calcification leading to growth deficit, rapid ageing and early death. The hyperphosphataemia of kl/kl mice results from excessive formation of 1,25(OH)2D3 causing excessive intestinal phosphate absorption. Further, kl/kl mice further suffer from hyperaldosteronism and compelling evidence points to an active role of mineralocorticoids...
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Lang, F., Ritz, E., Voelkl, J., Alesutan, I. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Arteriovenous access failure: more than just intimal hyperplasia?
Haemodialysis vascular access patency is severely compromised by fistula non-maturation and access stenosis. Intimal hyperplasia (IH) is considered the culprit lesion in failed fistulas, resulting in luminal narrowing and stenosis. This review focuses on the biology and pathophysiology of fistula failure and highlights not only the classically associated IH but also some relatively neglected but potentially important contributors such as inadequate outward remodelling. In addition, the complex process and fragile balance of successful fistula maturation might be partially hindered by pre-existent chronic kidney disease-med...
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Rothuizen, T. C., Wong, C., Quax, P. H. A., van Zonneveld, A. J., Rabelink, T. J., Rotmans, J. I. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

How important is transfusion avoidance in 2013?
Prior to the advent of recombinant erythropoietin in the late-1980s, blood transfusions were the mainstay of anaemia management in patients with end-stage renal failure, many of whom required "top-up" transfusions every 2 to 4 weeks to relieve the debilitating symptoms of severe anaemia. Erythropoietin therapy, however, allowed for the first time, such patients to achieve a sustained correction of anaemia, and there was a dramatic fall in both the use of red cell transfusions in dialysis units, as well as the associated transfusional iron overload prevalent in dialysis patients. Avoidance of blood transfusions improved acc...
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Macdougall, I. C., Obrador, G. T., El Nahas, M. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Medullary sponge kidney: state of the art
Medullary sponge kidney (MSK) is a kidney malformation that generally manifests with nephrocalcinosis and recurrent renal stones; other signs may be renal acidification and concentration defects, and pre-calyceal duct ectasias. MSK is generally considered a sporadic disorder, but an apparently autosomal dominant inheritance has also been observed. As MSK reveals abnormalities in both the lower and the upper nephron and is often associated with urinary tract developmental anomalies, its pathogenesis should probably be sought in one of the numerous steps characterizing renal morphogenesis. Given the key role of the GDNF-RET ...
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Fabris, A., Anglani, F., Lupo, A., Gambaro, G. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Obesity-related chronic kidney disease is associated with spleen-derived IL-10
Conclusions We suggest that obesity reduces IL-10 induction from the spleen, and spleen-derived IL-10 may protect against the development of CKD induced by obesity. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Gotoh, K., Inoue, M., Masaki, T., Chiba, S., Shiraishi, K., Shimasaki, T., Matsuoka, K., Ando, H., Fujiwara, K., Fukunaga, N., Aoki, K., Nawata, T., Katsuragi, I., Kakuma, T., Seike, M., Yoshimatsu, H. Tags: BASIC SCIENCE Source Type: research

Survival and distribution of injected haematopoietic stem cells in acute kidney injury
Conclusions Injected HSCs do not appear to significantly contribute to tubular repair or ameliorate renal damage in ischaemic AKI although they may show considerable engraftment in various organs. These data further challenge the concept that injection of HSCs may be used as a therapeutic approach in treating AKI. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Burst, V., Putsch, F., Kubacki, T., Volker, L. A., Bartram, M. P., Muller, R.-U., Gillis, M., Kurschat, C. E., Grundmann, F., Muller-Ehmsen, J., Benzing, T., Teschner, S. Tags: BASIC SCIENCE Source Type: research

Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice
Conclusions Dietary adenine caused advanced CKD with uraemia in mice providing a useful experimental model to study molecular and morphological changes associated with this disease. The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Santana, A. C., Degaspari, S., Catanozi, S., Delle, H., de Sa Lima, L., Silva, C., Blanco, P., Solez, K., Scavone, C., Noronha, I. L. Tags: BASIC SCIENCE Source Type: research

Hemodynamic response magnetic resonance imaging: application for renal hemodynamic characterization
Conclusions The applicability of the non-invasive HRI method suggests its potential use for the evaluation of renal perfusion and vascular reactivity, excluding the need for contrast-agent administration. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Milman, Z., Heyman, S. N., Corchia, N., Edrei, Y., Axelrod, J. H., Rosenberger, C., Tsarfati, G., Abramovitch, R. Tags: BASIC SCIENCE Source Type: research

Pretreatment with paricalcitol attenuates inflammation in ischemia-reperfusion injury via the up-regulation of cyclooxygenase-2 and prostaglandin E2
Conclusions Our study demonstrates that paricalcitol pretreatment prevents renal IRI via the inhibition of renal inflammation, and the up-regulation of COX-2 and PGE2 is one of the protective mechanisms of paricalcitol in renal IRI. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Hwang, H. S., Yang, K. J., Park, K. C., Choi, H. S., Kim, S. H., Hong, S. Y., Jeon, B. H., Chang, Y. K., Park, C. W., Kim, S. Y., Lee, S. J., Yang, C. W. Tags: BASIC SCIENCE Source Type: research

Urinalysis is more specific and urinary neutrophil gelatinase-associated lipocalin is more sensitive for early detection of acute kidney injury
Conclusions NGAL can be reliably measured in clinical urine samples, although pyuria is an important potential confounder. In our cohort, increased urinary NGAL was associated with AKI by the AKIN criteria; however, the sensitivity and specificity were only fair, in part because patients with pre-renal causes are not excluded by AKIN criteria. Conversely, findings on microscopic urinalysis are very specific for AKI. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Schinstock, C. A., Semret, M. H., Wagner, S. J., Borland, T. M., Bryant, S. C., Kashani, K. B., Larson, T. S., Lieske, J. C. Tags: Acute Kidney Injury Source Type: research

How acute kidney injury is investigated and managed in UK intensive care units--a survey of current practice
Conclusions Considerable variation exists in the investigation and management of AKI in UK ICUs. Despite increasing recognition of the importance of AKI, few ICUs are aware of RIFLE and AKIN criteria. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Jones, S. L., Devonald, M. A. J. Tags: Acute Kidney Injury Source Type: research

Evolution of the incidence of chronic kidney disease Stage 5 requiring renal replacement therapy in the diabetic population of Catalonia
Conclusions Since 2002, the rates of patients with DCKD initiating RRT among the overall DM population decreased slightly in Catalonia. Survival in these cases has increased progressively and in 2006 is similar to the CKD patients due to other causes. This figure suggests a better overall management, especially of CVRF. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Comas, J., Arcos, E., Castell, C., Cases, A., Martinez-Castelao, A., Donate, T., Esmatjes, E. Tags: Chronic Kidney Desease Source Type: research