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This page shows you the latest news and research items in this category.

Cone-beam computed tomography image guided therapy to evaluate lumpectomy cavity variation before and during breast radiotherapy.
Abstract The purpose of this study was to evaluate the rate of change (RoC) in the size of the lumpectomy cavity (LC) before and during breast radiotherapy (RT) using cone-beam computed tomography (CBCT), relative to the initial LC volume at CT simulation (CTVLC) and timing from surgery. A prospective institutional review board-approved study included 26 patients undergoing breast RT: 20 whole breast irradiation (WBI) patients and six partial breast irradiation (PBI) patients, with surgical clips outlining the LC. The patients underwent CT simulation (CTsim) followed by five CBCTs during RT, once daily for PBI and ...
Source: Journal of Applied Clinical Medical Physics - May 23, 2013 Category: Physics Authors: Truong MT, Hirsch AE, Kovalchuk N, Qureshi MM, Damato A, Schuller B, Vassilakis N, Stone M, Gierga D, Willins J, Kachnic LA Tags: J Appl Clin Med Phys Source Type: research

Can Older Early-Stage Breast Cancer Patients Skip Radiation?Can Older Early-Stage Breast Cancer Patients Skip Radiation?
There is no benefit in adding radiation to tamoxifen therapy in women aged 70 years or older after lumpectomy for early-stage breast cancer, according to long-term results of the CALGB 9343 trial. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 22, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Clinico- pathological profile of patients with breast diseases
Conclusions: Study shows that in Pakistani females, mostly encountered breast lesion was fibroadenoma. Due to lack of awareness breast diseases present lately. Awareness must be created among women to reduce the mortality and morbidity with breast lesions.Virtual slidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1037059088969395. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - May 9, 2013 Category: Pathology Authors: Hafiz AslamShafaq SaleemHiba ShaikhNazish ShahidAnum MughalRibak Umah Source Type: research

Tissue Compliance Meter is a More Reproducible Method of Measuring Radiation‐Induced Fibrosis than Late Effects of Normal Tissue–Subjective Objective Management Analytical in Patients Treated with Intracavitary Brachytherapy Accelerated Partial Breast Irradiation: Results of a Prospective Trial
In this study, we prospectively quantify RIF after intracavitary brachytherapy (IB) accelerated partial breast irradiation (APBI) with TCM and compare it with LENT‐SOMA. Thirty‐nine women with American Joint Committee on Cancer Stages 0‐I breast cancer, treated with lumpectomy and intracavitary brachytherapy delivered by accelerated partial breast irradiation (IBAPBI), were evaluated by two raters in a prospective manner pre‐IBAPBI and every 6 months post‐IBAPBI for development of RIF, using TCM and LENT‐SOMA. TCM classification scale grades RIF as 0 = none, 1 = mild, 2 = moderate, and 3 = severe, corr...
Source: The Breast Journal - April 24, 2013 Category: Cancer & Oncology Authors: A. Gabriella Wernicke, Eleni A. Greenwood, Shana Coplowitz, Bhupesh Parashar, Fridon Kulidzhanov, Paul J. Christos, Andrew Fischer, Dattatreyudu Nori, Kun S. Clifford Chao Tags: Original Article Source Type: research

Concurrent primary angiosarcoma and invasive ductal carcinoma in the same breast
Case presentation A 33-year-old Chinese female was admitted to a local hospital with a 20-day history of a painful lump in her right breast. Breast ultrasonography and mammography revealed a 2-cm irregular solid lesion in the breast. Previous exposure to radioactive or chemical substances and a history of extremity oedema were denied. A diagnosis of invasive carcinoma was made based on intraoperative frozen sections, and the patient underwent a right modified radical mastectomy in June 2009. A pathological examination revealed a high-grade invasive carcinoma with negative margins and axillary lymph nodes. The patient rejec...
Source: Journal of Clinical Pathology - February 21, 2013 Category: Pathology Authors: Ni, Y., Xie, X., Bu, H., Zhang, Z., Wei, B., Yin, L., Chen, M., Chen, H., Zhang, H. Tags: PostScript Source Type: research

A Population-Based Study of the Fractionation of Postlumpectomy Breast Radiation Therapy
Conclusions: The use of shorter schedules of post lumpectomy RT in Ontario increased after completion of the OCOG trial, but the trial had a less normative effect on practice than expected. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 21, 2013 Category: Radiology Authors: Allison Ashworth, Weidong Kong, Timothy Whelan, William J. Mackillop Tags: Breast Cancer Source Type: research

Low-Kilovoltage, Single-Dose Intraoperative Radiation Therapy for Breast Cancer: Results and Impact on a Multidisciplinary Breast Cancer Program
Conclusions: Implementation of IB impacts treatment planning and operating room use in a multidisciplinary breast cancer program. The safety profile, ease of administration, and reduced costs of IB favor its more widespread use in selected patients with early-stage breast cancer. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - February 15, 2013 Category: Surgery Authors: Stephen R. Grobmyer, Judith L. Lightsey, Curtis M. Bryant, Christiana Shaw, Anamaria Yeung, Niranjan Bhandare, Barbara Hitchingham, Edward M. Copeland Tags: Southern Surgical Association Articles Source Type: research

Breast-Conserving Therapy Improved Survival over Mastectomy
Women who underwent lumpectomy for stage I or II breast cancer were 28% less likely to die from any cause and up to 16% less likely to die from breast cancer, compared with women who underwent mastectomy,... (Source: OncologySTAT Latest News)
Source: OncologySTAT Latest News - February 13, 2013 Category: Cancer & Oncology Source Type: news

Ascertaining invasive breast cancer cases; the validity of administrative and self-reported data sources in Australia
Conclusions: In the absence of Cancer Registry data, administrative and self-reported data can be used to accurately identify cases of invasive breast cancer for sample identification, removing cases from a sample, or risk adjustment. Invasive breast cancer can be accurately identified using a combination of hospital-derived diagnosis, surgeries, and breast radiotherapy. (Source: BMC Medical Research Methodology - Latest articles)
Source: BMC Medical Research Methodology - Latest articles - February 11, 2013 Category: Research Authors: Anna KempDavid PreenChristobel SaundersC HolmanMax BulsaraKris RogersElizabeth Roughead Source Type: research

Characteristics and presentation of patients with breast cancer in Rwanda
Conclusions: This study is the first to characterize Rwandan patients with breast cancer. Our results highlight the needs for registries to capture stage, pathologic features, and survival, as well as the need for research on causes of delayed presentation in Rwanda. (Source: American Journal of Surgery)
Source: American Journal of Surgery - February 4, 2013 Category: Surgery Authors: Gita N. Mody, Afam Nduaguba, Faustin Ntirenganya, Robert Riviello Tags: Society of Black Academic Surgeons Source Type: research

Surgical Management of the Breast: Breast Conservation Therapy and Mastectomy
The twentieth century has witnessed dramatic changes in the surgical management of breast cancer. Herein we focus on the evolution of breast conservation surgery and current surgical trends of lumpectomy, mastectomy and contralateral prophylactic mastectomy. Margin analysis, specimen localization and processing, and the benefits of magnetic resonance imaging remain controversial. Neoadjuvant chemotherapy can offer prognostic information and aid in surgical planning while radiation therapy continues to reduce the risk of local recurrence after breast conserving surgery. Despite these advances, mastectomy remains a popular c...
Source: Surgical Clinics of North America - February 4, 2013 Category: Surgery Authors: Sarah A. McLaughlin Source Type: research

Tracking the dynamic seroma cavity using fiducial markers in patients treated with accelerated partial breast irradiation using 3D conformal radiotherapy.
Conclusions: Using the marker distance change as a surrogate for seroma volume, it appears that the seroma cavity experiences an exponential reduction in size. The change in seroma size has implications in the size of the CTV, PTV, and percent of normal breast tissue irradiated when using 3D-CRT. PMID: 23387740 [PubMed - in process] (Source: Medical Physics)
Source: Medical Physics - February 1, 2013 Category: Physics Authors: Yue NJ, Haffty BG, Kearney T, Kirstein L, Chen S, Goyal S Tags: Med Phys Source Type: research

Study: lumpectomy survival rates good for early breast cancer
(Reuters) - A new U.S. study examining survival rates for women with early stage breast cancer found that surgery such as lumpectomy that preserves the rest of the breast may offer survival odds as good as, or even better than, mastectomies. (Source: Reuters: Health)
Source: Reuters: Health - January 31, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Study supports lumpectomy in early breast cancer
NEW YORK (Reuters Health) - A new look at real-world outcomes for women with early-stage breast cancer finds that breast-conserving surgery may offer survival odds that are as good, or even better, than breast removal. (Source: Reuters: Health)
Source: Reuters: Health - January 30, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Phase 2 study of pre‐excision single‐dose intraoperative radiation therapy for early‐stage breast cancers
CONCLUSIONS:The rate of local events in this study is a matter of concern, especially in the Cautionary group. On the basis of these findings, pre‐excision IORT, as delivered in this study, may not provide adequate local control for less favorable early‐stage breast cancers. Cancer 2013;. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - January 29, 2013 Category: Cancer & Oncology Authors: Noam A. VanderWalde, Ellen L. Jones, Randall J. Kimple, Dominic T. Moore, Nancy Klauber‐DeMore, Carolyn I. Sartor, David W. Ollila Tags: Original Article Source Type: research

Video: Lumpectomy tops mastectomy in cancer treatment study
A study in the journal "Cancer" has found that women are 14 percent less likely to die from breast cancer after undergoing a lumpectomy followed by radiation treatment than after a mastectomy. Dr. Jon LaPook reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - January 28, 2013 Category: Consumer Health News Source Type: news

For Early Cancer, Lumpectomy Beats Mastectomy for Survival: Study
Findings should reassure women who fear breast-conserving surgery, expert says (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 28, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Gynecology, Oncology, Surgery, News, Source Type: news

Lumpectomy May Have Better Survival Than MastectomyLumpectomy May Have Better Survival Than Mastectomy
In a population-based cohort of women with early breast cancer, breast-conserving therapy was associated with better outcomes. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 28, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

For Early Cancer, Lumpectomy Beats Mastectomy for Survival
Findings should reassure women who fear breast-conserving surgery, expert says Source: HealthDay Related MedlinePlus Pages: Breast Cancer, Mastectomy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - January 28, 2013 Category: Consumer Health News Source Type: news

Breast Cancer Survival Better After Lumpectomy Than Mastectomy
Women with small early breast cancers may have a better chance of survival if they have lumpectomy plus radiation therapy than mastectomy, according to a new analysis due to be published early online in the journal Cancer this week. Although they did not determine why women who had mastectomy had a higher risk of dying, Shelley Hwang of the Duke Cancer Institute in the US, and colleagues, suggest their findings provide confidence in the effectiveness of breast-conserving treatments even in women who have aggressive, early breast cancers... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 28, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Better Survival Rates Seen With Lumpectomy Compared With Mastectomy For Early Breast Cancer
A new analysis has found that lumpectomy plus radiation for early breast cancer may provide patients with a better chance of survival than mastectomy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results provide confidence in the efficacy of breast-conserving treatments even among patients with aggressive, early disease. Lumpectomy combined with radiation is a good treatment choice for women with early breast cancer; however, over the past 10 years, a growing number of women have been choosing mastectomy even for very small cancers... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 28, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Lumpectomy with RT tops mastectomy for early-stage cancer
Women with early-stage breast cancer sometimes opt for mastectomy rather than (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 28, 2013 Category: Radiology Source Type: news

Less invasive treatment is associated with improved survival in early stage breast cancer
(Duke University Medical Center) Patients with early stage breast cancer who were treated with lumpectomy plus radiation may have a better chance of survival compared with those who underwent mastectomy, according to Duke Medicine research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 28, 2013 Category: Global & Universal Source Type: news

Survival after lumpectomy and mastectomy for early stage invasive breast cancer
CONCLUSIONS:Among patients with early stage breast cancer, BCT was associated with improved DSS. These data provide confidence that BCT remains an effective alternative to mastectomy for early stage disease regardless of age or HR status. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer)
Source: Cancer - January 28, 2013 Category: Cancer & Oncology Authors: E. Shelley Hwang, Daphne Y. Lichtensztajn, Scarlett Lin Gomez, Barbara Fowble, Christina A. Clarke Tags: Original Article Source Type: research

Less invasive treatment may increase survival in early stage breast cancer
(Duke University Medical Center) Patients with early stage breast cancer who are treated with lumpectomy plus radiation have a better chance of survival compared with those who undergo mastectomy, according to Duke Medicine research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 28, 2013 Category: Global & Universal Source Type: news

Better survival rates seen with lumpectomy compared with mastectomy for early breast cancer
(Wiley) A new analysis has found that lumpectomy plus radiation for early breast cancer may provide patients with a better chance of survival than mastectomy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results provide confidence in the efficacy of breast-conserving treatments even among patients with aggressive, early disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 28, 2013 Category: Global & Universal Source Type: news

Lumpectomy Saves Lives in Early Breast Cancer (CME/CE)
(MedPage Today) -- In real-world practice, women with early-stage breast cancer were more likely to survive if they had a lumpectomy rather than mastectomy, a population-based registry study found. (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - January 27, 2013 Category: OBGYN Source Type: news

For Early Cancer, Lumpectomy Beats Mastectomy for Survival: Study
Findings should reassure women who fear breast-conserving surgery, expert says (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - January 27, 2013 Category: Cancer & Oncology Source Type: news

MarginProbe System
The MarginProbe System is a diagnostic2 tool that uses electromagnetic waves. It is used by surgeons on patients undergoing surgery to remove a tumor from the breast (lumpectomy) that was diagnosed as breast cancer. (Approved: 12/27/2012) (Source: Medical Device Approvals)
Source: Medical Device Approvals - January 16, 2013 Category: Medical Equipment Source Type: news

Consumer Information on: MarginProbe System - P110014
The MarginProbe System is a diagnostic2 tool that uses electromagnetic waves. It is used by surgeons on patients undergoing surgery to remove a tumor from the breast (lumpectomy) that was diagnosed as breast cancer. (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - January 16, 2013 Category: Medical Equipment Source Type: news

A Prospective Randomized Double-Blinded Trial of Topical NSAID Therapy for the Reduction of Pain in Women Receiving Breast Radiation for Breast Cancer
Breast cancer is the most common cancer and second leading cause of cancer death in American women. Whole breast radiation is given after mastectomy or lumpectomy to prevent breast cancer recurrence. Up to 95% of patients who undergo radiation therapy will experience an inflammatory-mediated skin reaction. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that helps decrease inflammation and pain by inhibiting prostaglandin synthesis. We hypothesize that topical ketoprofen will decrease discomfort in patients undergoing whole breast radiotherapy for breast cancer through this mechanism. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: N.G. Callaway, W. Stone, P. Bistolarides Tags: Oral Session: Wednesday 2/6 7:30 AM to 9:30 AM Source Type: research

Early-Stage Breast Cancer Treated With 3-Week Accelerated Whole-Breast Radiation Therapy and Concomitant Boost
Conclusions: The prescribed accelerated schedule of whole-breast radiation therapy with concomitant boost can be administered, achieving acceptable dose distribution. With follow-up to date, the results are encouraging and suggest minimal side effects and excellent local control. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 4, 2013 Category: Radiology Authors: Manjeet Chadha, Rudolph Woode, Jussi Sillanpaa, David Lucido, Susan K. Boolbol, Laurie Kirstein, Michael P. Osborne, Sheldon Feldman, Louis B. Harrison Tags: Breast Cancer Source Type: research

Probe That Checks For Cancer On The Margin During Breast Lumpectomy Gets FDA Approval
A probe that allows surgeons removing cancerous tissue during breast "lumpectomy" to check if the margins of the removed tissue are clear of cancer cells, has received Premarket Approval (PMA) in the US from the Food and Drug Administration (FDA). Lumpectomy (surgery to remove a lump of tissue), in combination with radiation therapy, is as effective in treating breast cancer as mastectomy: but only if no cancer cells are present on the edge or rim of the removed tissue, also known as "clean margins"... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 3, 2013 Category: Consumer Health News Tags: Medical Devices / Diagnostics Source Type: news

New Device to Check Margins During Breast Cancer SurgeryNew Device to Check Margins During Breast Cancer Surgery
The new device, used intraoperatively during a lumpectomy to check margins in excised tissue, significantly reduced re-excision rates in a pivotal trial. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 2, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

[Comment] Reducing reoperation rates after breast-conserving surgery
Breast-conserving surgery (also variously called lumpectomy, partial mastectomy, wide local excision, segmentectomy, or quadrantectomy) is the preferred choice for local treatment of primary breast cancer, and most women are suitable candidates. However, except for elderly patients or those who have tumours with favourable features, most need postoperative adjuvant radiotherapy to further reduce their risk of local recurrence. (Source: The Lancet Oncology)
Source: The Lancet Oncology - December 29, 2012 Category: Cancer & Oncology Authors: Ismail Jatoi Tags: Comment Source Type: research

Intentions for bilateral mastectomy among newly diagnosed breast cancer patients
ConclusionsFor younger women, a surgical recommendation is associated with lower decisional conflict and stronger intention for BM. Results highlight the importance of effective risk communication and decision support between a woman and her surgeon. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - December 27, 2012 Category: Cancer & Oncology Authors: Lesley King, Suzanne C. O'Neill, Elizabeth Spellman, Beth N. Peshkin, Heiddis Valdimarsdottir, Shawna Willey, Kara Grace Leventhal, Tiffani DeMarco, Rachel Nusbaum, Elizabeth Feldman, Lina Jandorf, Marc D. Schwartz Tags: Research Article Source Type: research

The Effect of Positive Axillary Lymph Nodes on Symptoms, Physical Impairments, and Function
Conclusions: Functional impairments represent an important category of morbidity for BC survivors and should be considered in pre-treatment decision making. The number of positive ALN may not correlate with increased impairment over the first year of treatment when a prospective surveillance physical therapy program is part of the plan of care. Additional research is needed to assess longer-term changes and the impact of axillary surgery and/or radiation in the context of aggregate effects of other BC treatment modalities.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-11-13. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Kesarwala, A., Pfalzer, L., O'Meara, W., Stout, N. Tags: Poster Session 2 - Psychosocial, Quality of Life, and Educational Aspects: Survivorship Research Source Type: research

Multi-Institutional Evaluation of Bioimpedance Spectroscopy (BIS) in the Early Detection of Breast Cancer Related Lymphedema
Conclusions: In this multi-institutional analysis, L-Dex scores generated from multi-frequency bioimpedance spectroscopy (BIS) mirrored the aggressiveness of loco-regional therapy with respect to nodal sampling and radiation therapy. These findings suggest that BIS can be used in the early detection of BCRL and should be implemented before and following loco-regional therapies. Further studies are needed to help validate the extent, degree, and chronologic time frame of these changes to help define recommendations for closer monitoring and possible early intervention and to compare them to concurrent clinical assessments.C...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Vicini, F., Arthur, D., Shah, C., Anglin, B., Curcio, L., Laidley, A., Beitsch, P., Whitworth, P., Lyden, M. Tags: Poster Session 1 - Treatment: Toxicities - Management Source Type: research

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Conclusions: The use of a larger gauge core biopsy needle (e.g. 9-gauge) may yield superior tissue sampling and should likely be considered as the standard of care in the evaluation of image-detected breast abnormalities. In addition, biopsy results should not be considered definitively non-malignant when a high-risk lesion is identified. While there may be a trend towards not excising some of these high-risk lesions, we believe that a core biopsy demonstrating FEA still warrants surgical excision.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-02-01. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Tags: Poster Session 1 - Detection/Diagnosis: Biopsy Techniques Source Type: research

Patterns of definitive axillary management in the era prior to reporting ACOSOG Z0011: comparison between NCCN Centers and hospitals in Michigan
Conclusions: Omission of CALND occurred frequently in women with SLN positive breast cancer cared for in both NCCN and MiBOQI institutions in advance of reporting results of ACOSOG-Z0011. This shift was seen in management of patients undergoing lumpectomy as well as mastectomy. Further study is warranted to determine the extent of durable practice changes as well as any impact on survival and local-regional control.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-13. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Breslin, T., Hwang, S., Mamet, R., Hughes, M., Otteson, R., Edge, S., Moy, B., Rugo, H., Wong, Y.-N., Wilson, J., Laronga, C., Weeks, J., Silver, S., Marcom, P. Tags: Poster Session 1 - Detection/Diagnosis: Axillary Staging and Sentinel Nodes Source Type: research

A Nomogram for predicting two or less axillary lymph node involvement for breast cancer
CONCLUSION: Patients with a low probability of having three or more positive nodes can be identified from preoperative image finding. The nomogram developed will be helpful to surgeons making decision about sparing intraoperative frozen section analysis of sentinel lymph.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-08. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Ahn, S., Kim, J., Kim, M., Lee, J., Kim, T., Kim, J., Moon, H., Han, W., Noh, D.-Y. Tags: Poster Session 1 - Detection/Diagnosis: Axillary Staging and Sentinel Nodes Source Type: research

Intraoperative assessment of tumor margins with a new optical imaging technology: A multi-center, randomized, blinded clinical trial
Background: Partial mastectomy is the most commonly performed procedure for invasive breast cancer and is associated with a reexcision rate commonly ranging from 20% to 40% in the literature. This high rate of reexcision is associated with significant additional cost (estimated over $4,000 per reexcision) and lower quality outcomes.Optical coherence tomography (OCT) is a high-resolution imaging technology that images tissue structure with micron-scale resolution – on the same scale as histopathology. It is similar to ultrasound except it uses near infra-red light waves instead of sound waves to create detailed images...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Jacobs, L., Carney, P., Cittadine, A., McCormick, D., Somera, A., Darga, D., Putney, J., Adie, S., Ray, P., Cradock, K., Tafra, L., Gabrielson, E., Boppart, S. Tags: Ongoing Trials 2 - Surgery / Nodes Source Type: research

Clinical node negative breast cancer patients undergoing breast conserving therapy: follow-up versus sentinel lymph node biopsy
This study is expected to start in late 2012 after approval by the Ethical Medical Committee.References1. Giuliano, A.E., et al., Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA, 2011. 305(6): p. 569–75.2. Neal, C.H., et al., Can preoperative axillary US help exclude N2 and N3 metastatic breast cancer? Radiology, 2010. 257(2): p. 335–41.3. Aaronson, N.K., et al., The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: van Roozendaal, L., Smidt, M., de Wilt, H., van Dalen, T., Strobbe, L., van der Hage, J., Tjan-Heijnen, V., Linn, S., Serroyen, J. Tags: Ongoing Trials 2 - Surgery / Nodes Source Type: research

NSABP B-43: A phase III clinical trial to compare trastuzumab (T) given concurrently with radiation therapy (RT) to RT alone for women with HER2+ DCIS resected by lumpectomy (Lx)
Background: A significant amount of DCIS is ER negative and/or overexpresses HER2. This provides an opportunity to test molecular therapy in DCIS.In xenograft models and cell lines, T boosts RT effectiveness. In T-treated HER2+ patients, apoptosis occurs within 1 wk of single agent T use, with T found in ductal aspirates. Ample safety evidence for T exists. T given during whole breast irradiation (WBI) may improve results for lumpectomy (Lx) resected HER2+ DCIS. A trial to examine this question will enhance the understanding of breast tumor biology and the prevention of such tumors and could possibly extend breast-conservi...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Cobleigh, M., Anderson, S., Julian, T., Siziopikou, K., Arthur, D., Rabinovitch, R., Zheng, P., Mamounas, E., Wolmark, N. Tags: Ongoing Trials 1 - Radiation Therapy Source Type: research

Factors which affect surgical management in an underinsured, county hospital population
Conclusions: Breast conservation and mastectomy with reconstruction can be achieved in a significant proportion (74%) of underscreened and underinsured patients. Patients who underwent preoperative chemotherapy were more likely to undergo breast conservation. Younger patients and patients with adequate HL were more likely to choose reconstruction after mastectomy. Patients treated by breast surgical oncologists were more likely to have breast conservation or mastectomy with reconstruction. Even in an underscreened population, presentation with metastatic disease is uncommon in patients with operable breast cancer.Citation ...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Komenaka, I., Olsen, L., Klemens, A., Hsu, C.-H., Nodora, J., Martinez, M., Thompson, P., Bouton, M. Tags: Poster Discussion 8 - Disparities Source Type: research

Molecular Profiling for In Situ Carcinoma of the Breast
The management of in situ carcinoma of the breast represents a clinical dilemma. Such a non-invasive lesion places the patient at risk for subsequent development of an invasive lesion, and various treatments have been shown to reduce this risk. However, most patients are asymptomatic at initial presentation, and standard treatments are associated with the risk of side effects. It can be difficult for the individual patient to find the most appropriate balance between the risks and benefits of adding treatment. Although many patients elect for all treatments to minimize risk of progression regardless of potential side effec...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Solin, L. Tags: Educational Session 1 - The Practical Use of Molecular Profiling Source Type: research

Brinker Award Lecture: Older Women and Breast Cancer: Challenges and Opportunities
In the United States and other developed nations breast cancer incidence and mortality rates rise dramatically with increasing age. This fact, coupled with the aging of the U.S population is leading to a tsunami of older women with breast cancer. Most oncologists lack training in geriatrics and the frequent comorbidities in older patients along with a new diagnosis of breast cancer makes treatment selection challenging. Little data from clinical trials are available to guide physicians in treatment selection and a paucity of geriatricians makes it difficult to develop comprehensive treatment plans for many older patients. ...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Muss, H. Tags: Susan G. Komen for the Cure Brinker Awards for Scientific Distinction Lectures Source Type: research

Myoepithelial Carcinoma of the Breast with Focal Rhabdoid Features
Abstract Myoepithelial carcinoma of the breast is extremely rare and only 33 cases have been reported in the English literature. Herein, we report a case of myoepithelial carcinoma of the breast with focal rhabdoid features. The patient was a 67‐year‐old woman, who presented with a lump of the left breast that rapidly grew to 3 cm in diameter within 3 months. Lumpectomy revealed a solid and whitish colored tumor, which was composed mainly of elongated spindle‐shaped cells with mild atypia, focal necrosis, and infiltrative margin. In a small area of the lesion, ovoid tumor cells exhibited eccentric nuclei with centr...
Source: The Breast Journal - December 17, 2012 Category: Cancer & Oncology Authors: Hiroya Ohtake, Akiko Iwaba, Tomoya Kato, Rintaro Ohe, Kunihiko Maeda, Mikio Matsuda, Kazuhiko Izuru, Kazuhiro Morimoto, Shigeru Katagiri, Mitsunori Yamakawa Tags: Case Report Source Type: research

Symptoms, Physical Impairments, and Function in Breast Cancer Patients with Negative Axillary Lymph Nodes
Conclusions: Functional impairments represent an important category of morbidity for BC survivors and should be considered in pre-treatment decision making. In patients without axillary disease, post-operative RNRT or whole breast tangent RT may not contribute significantly to impairment over the first year of treatment when a prospective surveillance physical therapy program is part of the plan of care. Additional research is needed to assess longer-term changes and the impact of radiation in the context of the aggregate effect of disease burden combined with other BC treatment modalities.Citation Information: Cancer Res ...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Kesarwala, A., Pfalzer, L., O'Meara, W., Stout, N. Tags: Poster Session 2 - Psychosocial, Quality of Life, and Educational Aspects: Survivorship Research Source Type: research

A pilot prospective study of adherence to aromatase inhibitor adjuvant therapy in patients with stage 1-3 breast carcinoma.
Conclusions: Overall adherence to AI treatment measured by MMAS was High in 50.7%, Medium in 35.6% and Low in 13.7% pts; there was no difference in adherence by duration of treatment with AI ≤ 2 vs. > 2 years. Univariable regression models for continuous predictors and rxc contingency tables for categorical ones revealed that the adherence to AI therapy is not affected by age, marital status, education, prior cancer therapy, tumor stage, and concurrent medication. However, there was a trend for better adherence to AI therapy in Caucasian women vs. AAF (p = 0.013). The study is ongoing.Citation Information: Cancer Res...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Heiss, B., Thompson, J., Nightingale, G., Tait, N., Kesmodel, S., Bellavance, E., Chumsri, S., Bao, T., Goloubeva, O., Feigenberg, S., Tkaczuk, K. Tags: Poster Session 2 - Treatment: Endocrine Therapy - Adjuvant Source Type: research