Skin Biopsy This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Pityriasis rosea–like eruption associated with lamotrigine
To the Editor: Pityriasis rosea (PR)–a common, acute, self-limited eruption–is characterized by an initial herald patch followed by a diffuse papulosquamous rash without systemic manifestations. Occasionally a lesional skin biopsy is important to rule out other papulosquamous and erythematous disorders. PR-like drug eruptions from angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, barbiturates, and beta-blockers, but not from lamotrigine have been reported. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 24, 2013 Category: Dermatology Authors: Papadavid Evangelia, Panayiotides Ioannis, Makris Michael, Giatrakou Sophia, Dalamaga Maria, Nikolaos Stavrianeas, Rigopoulos Dimitrios Tags: JAAD Online Source Type: research

Pure autonomic failure with cold induced sweating.
Abstract Pure autonomic failure (PAF) is a progressive autonomic neurodegenerative disorder. Cold induced sweating occurred in syndromes with mutations in CRLF1 and CLCF1 genes and in a case of cervical dissection. A patient with PAF developed sweating induced by cool ambient temperatures. He had severe orthostatic hypotension, abnormal cardiovagal reflexes, and paradoxical sweating in the upper trunk at a room temperature of 18°C. Skin biopsy showed involvement of somatic epidermal unmyelinated nerve fibers. Quantitative sensory testing showed abnormal thresholds to all thermal modalities. Possible mechanisms inc...
Source: Autonomic Neuroscience - May 23, 2013 Category: Neuroscience Authors: Idiaquez J, Fadic R, Verdugo R, Idiaquez JF, Iodice V, Low DA, Mathias CJ, Lombardi R, Lauria G Tags: Auton Neurosci Source Type: research

Altered mRNA and protein expression of filaggrin in the skin of a canine animal model for atopic dermatitis.
CONCLUSIONS AND CLINICAL IMPORTANCE: Altered epidermal filaggrin mRNA expression and protein distribution was detected in this experimental model. PMID: 23668858 [PubMed - in process] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - May 23, 2013 Category: Veterinary Research Authors: Santoro D, Marsella R, Ahrens K, Graves TK, Bunick D Tags: Vet Dermatol Source Type: research

Proliferative, lymphocytic, infundibular mural folliculitis and dermatitis with prominent follicular apoptosis and parakeratotic casts in four Labrador retrievers: preliminary description and response to therapy.
CONCLUSIONS AND CLINICAL IMPORTANCE: The cause of the lesions is unknown; the presence of intraepithelial CD3+ lymphocytes and cleaved caspase-3-positive apoptotic keratinocytes and the positive response to immunosuppressive therapy suggest an immune response directed towards unidentified antigens expressed on the surface of keratinocytes. PMID: 23600606 [PubMed - in process] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - May 23, 2013 Category: Veterinary Research Authors: Hargis AM, Myers S, Gortel K, Duclos D, Randolph-Habecker J Tags: Vet Dermatol Source Type: research

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases.
CONCLUSIONS AND CLINICAL IMPORTANCE: There was no observable difference in the histopathological pattern of calcinosis cutis from dogs with endogenous hyperglucocorticism versus iatrogenic hyperglucocorticism. While glucocorticoid therapy appears to predispose dogs to developing calcinosis cutis, it remains unclear whether there is a specific dose or combination of factors that initiates the mineral deposition. Furthermore, the mineral deposition in dogs with calcinosis cutis was found to be apatite. PMID: 23565978 [PubMed - in process] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - May 23, 2013 Category: Veterinary Research Authors: Doerr KA, Outerbridge CA, White SD, Kass PH, Shiraki R, Lam AT, Affolter VK Tags: Vet Dermatol Source Type: research

Assessment of donor biopsies.
Abstract PURPOSE OF REVIEW: To provide an up-to-date overview about the assessment of donor biopsies and to discuss the current problems and chances of preimplantation biopsies for transplant allocation with a focus on the technical work up and the histological variables scored. RECENT FINDINGS: Preimplantation biopsy results are the major reason for discarding procured extended donor criteria kidneys in the USA. There is neither a consensus on the work up, nor the reporting of preimplantation donor biopsies, nor the importance of the biopsy findings in the process of allocation. The best available data have be...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: Hopfer H, Kemény E Tags: Curr Opin Organ Transplant Source Type: research

Development and evaluation of spatial point process models for epidermal nerve fibers.
Abstract We propose two spatial point process models for the spatial structure of epidermal nerve fibers (ENFs) across human skin. The models derive from two point processes, Φb and Φe, describing the locations of the base and end points of the fibers. Each point of Φe (the end point process) is connected to a unique point in Φb (the base point process). In the first model, both Φe and Φb are Poisson processes, yielding a null model of uniform coverage of the skin by end points and general baseline results and reference values for moments of key physiologic indicators. The second model provides a mechanistic ...
Source: Mathematical Biosciences - May 23, 2013 Category: Statistics Authors: Olsbo V, Myllymäki M, Waller LA, Särkkä A Tags: Math Biosci Source Type: research

Proteolytic activation of prochemerin by kallikrein 7 breaks an ionic linkage and results in C-terminal rearrangement.
Abstract The excessive accumulation of adipose tissue in obesity is associated with multiple inflammatory dermatological diseases. Chemerin, a chemoattractant adipokine, dependent on proteolytical activation, is highly expressed in skin. Different proteases have been reported to activate prochemerin, but none is inherently expressed in human skin. In the present study, we identified a tissue-specific protease and investigated the underlying mechanism of activation at the molecular level. We characterized human KLK7 (kallikrein 7) as a prochemerin processing protease in vitro converting prochemerin into active chem...
Source: The Biochemical Journal - May 22, 2013 Category: Biochemistry Authors: Schultz S, Saalbach A, Heiker JT, Meier R, Zellmann T, Simon JC, Beck-Sickinger AG Tags: Biochem J Source Type: research

Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients
Conclusions These cutaneous side-effects are cause of concern due to their intrinsic potential for malignancy or because of their impact on patients' quality of life. Management of this skin toxicity relies on symptomatic measures and sun photoprotection. (Source: Annals of Oncology)
Source: Annals of Oncology - May 21, 2013 Category: Cancer & Oncology Authors: Boussemart, L., Routier, E., Mateus, C., Opletalova, K., Sebille, G., Kamsu-Kom, N., Thomas, M., Vagner, S., Favre, M., Tomasic, G., Wechsler, J., Lacroix, L., Robert, C. Tags: sarcomas and melanoma Source Type: research

No-treatment approach may be best choice for older prostate cancer patients
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multi-center study led by researchers from the UCLA Department of Urology. The study reports 14-year survival outcomes for 3,000 men diagnosed with prostate cancer between 1994 and 1995. The results suggest that older patients with low- or intermediate-risk prostate cancer who have at least three underlying health problems, or comorbidities, are much more likely to die of something other than their cancer. "For men with low-to-intermediate...
Source: UCLA Newsroom: Health Sciences - May 20, 2013 Category: Universities & Medical Training Source Type: news

Excessive Peptidergic Sensory Innervation of Cutaneous Arteriole–Venule Shunts (AVS) in the Palmar Glabrous Skin of Fibromyalgia Patients: Implications for Widespread Deep Tissue Pain and Fatigue
ConclusionsThe excessive sensory innervation to the glabrous skin AVS is a likely source of severe pain and tenderness in the hands of FM patients. Importantly, glabrous AVS regulate blood flow to the skin in humans for thermoregulation and to other tissues such as skeletal muscle during periods of increased metabolic demand. Therefore, blood flow dysregulation as a result of excessive innervation to AVS would likely contribute to the widespread deep pain and fatigue of FM. SNRI compounds may provide partial therapeutic benefit by enhancing the impact of sympathetically mediated inhibitory modulation of the excess sensory ...
Source: Pain Medicine - May 20, 2013 Category: Anesthesiology Authors: Phillip J. Albrecht, Quanzhi Hou, Charles E. Argoff, James R. Storey, James P. Wymer, Frank L. Rice Tags: Research Article Source Type: research

Antiviral therapy of symptomatic HCV-mixed  cryoglobulinemia after liver transplant: Case  report and literature review.
We report on a 48-year-old man who developed HCV-associated cryoglobulinemic vasculitis with recurrent hepatitis after liver transplant. One year after transplant for HCV-positive  cirrhosis, he presented severe cutaneous manifestations, and biopsy-proven cryoglobulinemic membrano-proliferative glomerulonephritis (MPGN). HCV RNA clearance occurred within a few weeks of antiviral therapy; sustained viral response (SVR) was obtained by one year of anti-HCV combination therapy (eight months of pegylated IFN/ribavirin and four months of standard IFN/ribavirin). SVR was linked to complete remission of skin, liver, and kidney ...
Source: The International Journal of Artificial Organs - May 17, 2013 Category: Transplant Surgery Authors: Francesca Donato M, Banfi G, Cresseri D, Battista Fogazzi G, Martin P, Messa P, Fabrizi F Tags: Int J Artif Organs Source Type: research

Senile gluteal dermatosis: a clinical study of 137 cases
ConclusionsSGD is a common dermatosis, mostly affecting the thinner elderly. Friction, pressures and long hours sitting seemed to be important factors to trigger this dermatosis. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - May 15, 2013 Category: Dermatology Authors: Han‐Nan Liu, Wen‐Jen Wang, Chih‐Chiang Chen, Ding‐Dar Lee, Yun‐Ting Chang Tags: Report Source Type: research

Clinical and histopathological characteristics of a family with R1141X mutation of pseudoxanthoma elasticum – presymptomatic testing and lack of carrier phenotypes
ConclusionThe mutation analyses of ABCC6 gene are important to determine the genotype of both patients with PXE and putative heterozygous carriers, as histopathological features of carriers may differ even in the same family. The role of antioxidant therapy for PXE is unclear, and there is a need for controlled clinical trials. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - May 15, 2013 Category: Dermatology Authors: Gulsen Akoglu, Qiaoli Li, Ozay Gokoz, Ali Serhan Gazyagci, Jouni Uitto Tags: Report Source Type: research

Protease-activated receptors are expressed in human tendon tissue and may explain excessive pain-signalling in tendinopathy
Discussion These findings give basis for further studies into the interactions of SP-positive nerves and mast cells in tendon pathology. Earlier studies have shown regulation of vascular permeability and dilation, as well as fibroblast proliferation through activation of PARs. The PAR4 may, through activation of proteases released from mast cells, to some extent be responsible not only for tenocyte proliferation and vascular regulation, but also for an enhanced pain signalling in tendinopathy through SP-positive afferents. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - May 10, 2013 Category: Sports Medicine Authors: Andersson, G., Alfredson, H. Tags: Degenerative joint disease, Musculoskeletal syndromes Abstracts from the 2nd International Scientific Tendinopathy Symposium (Vancouver, 2012) Source Type: research

Antibacterial activities of almond skins on cagA-positive and-negative clinical isolates of Helicobacter pylori
Conclusions: The Polyphenols from almond skins were effective in vitro against H. pylori, irrespective of genotype status and could therefore be used in combination with antibiotics as a novel strategy for antibiotic resistance. (Source: BMC Microbiology - Latest articles)
Source: BMC Microbiology - Latest articles - May 9, 2013 Category: Microbiology Authors: Carlo BisignanoAngela FilocamoErminia La CameraSebastiana ZummoMaria FeraGiuseppina Mandalari Source Type: research

Microbiology of folliculitis: a histological study of 39 cases
In conclusion, one‐third of patients with clinically diagnosed, non‐infectious folliculitis exhibited microbial colonization with predominance of Staphylococcus spp. (Source: APMIS)
Source: APMIS - May 8, 2013 Category: Research Authors: Anika C. Jahns, Bertil Lundskog, Johanna Berg, Rebecca Jonsson, Andrew McDowell, Sheila Patrick, Irina Golovleva, Ruth H. Palmer, Oleg A. Alexeyev Tags: Original Article Source Type: research

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection
Nature advance online publication 08 May 2013. doi:10.1038/nature12110 Authors: Jia Zhu, Tao Peng, Christine Johnston, Khamsone Phasouk, Angela S. Kask, Alexis Klock, Lei Jin, Kurt Diem, David M. Koelle, Anna Wald, Harlan Robins & Lawrence Corey Most herpes simplex virus 2 (HSV-2) reactivations in humans are subclinical and associated with rapid expansion and containment of virus. Previous studies have shown that CD8+ T cells persist in genital skin and mucosa at the dermal–epidermal junction (DEJ)—the portal of neuronal release of reactivating virus—for prolonged time periods after herpes lesi...
Source: Nature AOP - May 8, 2013 Category: Research Authors: Jia ZhuTao PengChristine JohnstonKhamsone PhasoukAngela S. KaskAlexis KlockLei JinKurt DiemDavid M. KoelleAnna WaldHarlan RobinsLawrence Corey Tags: Letter Source Type: research

Rose Gardener's disease
A 32-year-old man worked as a subsistence farmer raising pigs and tending his small garden; he also kept cats and dogs. He reported fever, night sweats, weight loss of 10 kg over 3 months, haemoptysis and skin ulcers (figure 1). Radiography and chest CT scan (figure 2) showed extensive bilateral cavities. An HIV test was negative. Bronchoalveolar lavage and biopsy of the skin lesions displayed Sporothrix schenckii. He was treated with amphotericin B and his lesions slowly healed. Sporotrichosis is a chronic pyogranulomatous infection caused by a dimorphic fungus that contaminates skin or subcutaneous tissue after...
Source: Thorax - May 8, 2013 Category: Respiratory Medicine Authors: Rufino, R., Marques, B. L., Costa, C. H. Tags: Journalology, Hemoptysis, Drugs: infectious diseases, HIV/AIDS, Radiology (diagnostics), Ethics Chest clinic Source Type: research

Multicenter Phase II Study of Neoadjuvant Lapatinib and Trastuzumab With Hormonal Therapy and Without Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer: TBCRC 006 [Breast Cancer]
Conclusion In patients with locally advanced HER2-positive breast cancer, our approach of targeted therapy only resulted in a high pCR rate without chemotherapy. Our data support the hypothesis that selected patients with HER2-positive tumors may not need chemotherapy, and more-complete blockade of HER receptors and ER is an effective strategy worthy of further study. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 7, 2013 Category: Cancer & Oncology Authors: Rimawi, Mayer, Forero, Nanda, Goetz, Rodriguez, Pavlick, Wang, Hilsenbeck, Gutierrez, Schiff, Osborne, Chang Tags: Combined Modality, Hormonal Therapy, Translational Oncology, Breast Cancer Source Type: research

Contribution of QSART to the diagnosis of small fiber neuropathy
Discussion Assessment of both somatic and peripheral autonomic small nerve fibers enhances diagnostic criteria for SFN. © 2013 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 4, 2013 Category: Internal Medicine Authors: Pariwat Thaisetthawatkul, J Americo M Fernandes Filho, David N Herrmann Tags: Research Article Source Type: research

miR‐155 is involved in tumor progression of mycosis fungoides
This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)
Source: Experimental Dermatology - May 1, 2013 Category: Dermatology Authors: L. Moyal, A. Barzilai, .B. Gorovitz, A. Hirshberg, N. Amariglio, J. Jacob‐Hirsch, L. Maron, M. Feinmesser, E. Hodak Tags: Letter to the Editor Source Type: research

Sweet's syndrome associated with systemic lupus erythematosus: A case report and review of the literature
Abstract A 35‐year‐old Japanese female patient with systemic lupus erythematosus (SLE) presented with fever, erythematous papules and nodules, and polyarthralgia. Skin biopsy of a nodule was compatible with Sweet's syndrome. The papules/nodules were well treated with an oral glucocorticoid. Thirty cases of Sweet's syndrome associated with lupus erythematosus (LE) have been reported in the published work. The mean age was 34.2 years. They showed a higher male ratio (male : female, 1:2) compared with patients with SLE (1:9) and Sweet's syndrome (1:3.7). Sweet's syndrome may occur as a manifestation of LE, and a modera...
Source: The Journal of Dermatology - May 1, 2013 Category: Dermatology Authors: Hideaki Tsuji, Hajime Yoshifuji, Ran Nakashima, Yoshitaka Imura, Naoichiro Yukawa, Koichiro Ohmura, Aya Miyagawa‐Hayashino, Kenji Kabashima, Tsuneyo Mimori Tags: Concise Communication Source Type: research

Arteriovenous Fistula After Superficial Temporal Artery Biopsy
We present the first reported case of an arteriovenous fistula after temporal artery biopsy and review the literature on the pathophysiology, diagnosis, and treatment of arteriovenous fistula. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - April 28, 2013 Category: Surgery Authors: Mikhael Janssen, Johan Vaninbroukx, Inge Fourneau Tags: Case Report Abstracts Source Type: research

Adult‐onset systemic Langerhans cell histiocytosis mimicking inflammatory bowel disease: the value of skin biopsy and review of cases of Langerhans cell histiocytosis with cutaneous involvement seen at the Mayo Clinic
ConclusionsGastrointestinal involvement with LCH is rare, can be easily misdiagnosed, and likely portends a poor prognosis. In patients with ill‐defined systemic symptoms, cutaneous exam and biopsy have the potential to diagnose systemic disease. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - April 28, 2013 Category: Dermatology Authors: Joshua O. Podjasek, Conor G. Loftus, Thomas C. Smyrk, Carilyn N. Wieland Tags: Report Source Type: research

Role of NF‐κB in the pathogenesis of psoriasis elucidated by its staining in skin biopsy specimens
ConclusionsThe study has demonstrated that translocation of NF‐κB in the epidermis and basal cells is responsible for two of the key pathological features of psoriasis, epidermal hyperplasia, and inflammation. We have postulated that translocation of NF‐κB in lymphocytes, in psoriatic skin leads to NF‐κB translocation in the epidermis and basal cells. NF‐κB is therefore likely to be one of the key molecules in the pathogenesis of psoriasis. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - April 28, 2013 Category: Dermatology Authors: Nikhil Moorchung, Janmeet S. Kulaar, Manas Chatterjee, Biju Vasudevan, Tanu Tripathi, Vibha Dutta Tags: Report Source Type: research

Positive immunostaining for feline infectious peritonitis (FIP) in a Sphinx cat with cutaneous lesions and bilateral panuveitis
Abstract Feline infectious peritonitis (FIP) is a common, fatal, systemic disease of cats. This case report describes the antemortem diagnosis of FIP in a 2‐year‐old spayed female Sphinx cat that presented with a bilateral panuveitis and multiple papular cutaneous lesions. Histopathologically, the skin lesions were characterized by perivascular infiltrates of macrophages, neutrophils, with fewer plasma cells, mast cells, and small lymphocytes in the mid‐ to deep dermis. Immunohistochemistry for intracellular feline coronavirus (FeCoV) antigen demonstrated positive staining in dermal macrophages providing an antemorte...
Source: Veterinary Ophthalmology - April 25, 2013 Category: Veterinary Research Authors: Bianca S. Bauer, Moira E. Kerr, Lynne S. Sandmeyer, Bruce H. Grahn Tags: Case Report Source Type: research

Ustekinumab improves psoriasis‐related gene expression in noninvolved psoriatic skin without inhibition of the antimicrobial response
Conclusions These findings indicate that ustekinumab reduces psoriasis‐related gene expression in noninvolved psoriatic skin, making it more resistant to exogenous triggering, without disturbing its antimicrobial response. In parallel, ustekinumab modulates important circulating inflammation‐related proteins. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 25, 2013 Category: Dermatology Authors: E.M. Baerveldt, A.J. Onderdijk, D. Kurek, M. Kant, E.F. Florencia, A.S. Ijpma, P.J. van der Spek, J. Bastiaans, P.A. Jansen, J.W.J. van Kilsdonk, J.D. Laman, E.P. Prens Tags: CLINICAL AND LABORATORY INVESTIGATIONS Source Type: research

Long‐term efficacy of single‐dose radiofrequency‐induced heat therapy vs. intralesional antimonials for cutaneous leishmaniasis in India
Conclusions A single application of RFHT is safe, cosmetically acceptable and effective in inducing a long‐term cure of CL. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 25, 2013 Category: Dermatology Authors: R.A. Bumb, N. Prasad, K. Khandelwal, N. Aara, R.D. Mehta, B.C. Ghiya, P. Salotra, L. Wei, S. Peters, A.R. Satoskar Tags: CONCISE COMMUNICATION Source Type: research

Dynamic changes in the contractile apparatus during exercise
This article is protected by copyright. All rights reserved. (Source: Acta Physiologica)
Source: Acta Physiologica - April 25, 2013 Category: Physiology Authors: David G. Allen Tags: Editorial Source Type: research

Eyebrow hairs from actinic keratosis patients harbor the highest number of cutaneous human papillomaviruses
Conclusions: Thus, eyebrow hairs revealed the highest number of cutaneous HPV infections, are easy to collect and are an appropriate screening tool in order to identify a possible association of HPV and AK. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 24, 2013 Category: Infectious Diseases Authors: Ines SchneiderMandy LehmannVlada KogosovEggert StockflethIngo Nindl Source Type: research

Thymic Stromal Lymphopoietin Is Up‐Regulated in the Skin of Patients With Systemic Sclerosis and Induces Profibrotic Genes and Intracellular Signaling That Overlap With Those Induced by Interleukin‐13 and Transforming Growth Factor β
ConclusionTSLP is highly expressed in the skin of dcSSc patients and interacts in a complex manner with 2 other profibrotic cytokines, TGFβ and IL‐13, strongly suggesting that it might promote SSc fibrosis directly or indirectly by synergistically stimulating profibrotic genes, or production of these cytokines. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 23, 2013 Category: Rheumatology Authors: Romy B. Christmann, Allison Mathes, Alsya J. Affandi, Cristina Padilla, Banafsheh Nazari, Andreea M. Bujor, Giuseppina Stifano, Robert Lafyatis Tags: Systemic Sclerosis Source Type: research

Interleukin‐17A+ Cell Counts Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated With the Extent of Skin Involvement
ConclusionIL‐17A+ cells belonging to the innate and adaptive immune system are numerous in SSc skin. IL‐17A participates in inflammation while exerting an inhibitory activity on myofibroblast transdifferentiation. These findings are consistent with the notion that IL‐17A has a direct negative‐regulatory role in the development of dermal fibrosis in humans. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 23, 2013 Category: Rheumatology Authors: Marie‐Elise Truchetet, Nicolò‐Costantino Brembilla, Elisa Montanari, Paola Lonati, Elena Raschi, Silvana Zeni, Lionel Fontao, Pier‐Luigi Meroni, Carlo Chizzolini Tags: Systemic Sclerosis Source Type: research

Leonine facies in a 43-year-old man
A 43-year-old Asian man presented with a 13-year history of a slowly progressive mildly pruritic rash. The physical examination revealed diffuse brown-to-erythematous, eczematous infiltrated papules and plaques with accentuated skin creases and follicular openings of the face, resulting in a leonine facies appearance ( and , A). There were also diffuse hyperkeratotic and erythematous papules and nodules on the extensor surface of the forearms and elbows, the dorsal surfaces of the hands, lower legs, V-neck, and upper aspect of the back (, B and ). Previous and recent biopsy specimens revealed no evidence of granulomatous i...
Source: Journal of the American Academy of Dermatology - April 22, 2013 Category: Dermatology Authors: Yu-Ting Lin, Yu-Chen Huang, Ying-Yi Chiang Tags: Images in Dermatology Source Type: research

Reflectance confocal microscopy for the characterization of mycosis fungoides and correlation with histology: a pilot study
ConclusionThe utility of RCM as a diagnostic tool for MF awaits further evaluation, although it appears to be promising for biopsy site selection. (Source: Skin Research and Technology)
Source: Skin Research and Technology - April 22, 2013 Category: Dermatology Authors: Wei Li, Hui Dai, Zhao Li, Ai‐E Xu Tags: Original Article Source Type: research

Immunohistochemical evaluation of p53 and Ki67 expression in skin epithelial tumors
Conclusion: This study showed that the incidence rate of p53- and Ki67-positive cells is very high in skin malignant epithelial tumors. The expression rate of these two variables is comparable with reports in the literature. Further studies with large sample size are recommended to be carried out for KA and TE samples. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Effat KhodaeianiAshraf FakhrjouMehdi AmirniaShahla Babaei-nezhadFarshid TaghvamaneshElham Razzagh-KarimiHossein Alikhah Source Type: research

Simulation-based cutaneous surgical-skill training on a chicken-skin bench model in a medical undergraduate program
Conclusion: The teaching of a methodology for the principles of cutaneous surgery using a chicken-skin bench model versatile, portable, easy to assemble, and inexpensive is an alternative and complementary option to the armamentarium of methods based on other bench models described. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Rafael DenadaiRogerio Saad HossneLuis Ricardo Martinhao Souto Source Type: research

Alopecia mucinosa responding to antileprosy treatment: Are we missing something?
Rajiv Joshi, Vinay GopalaniIndian Journal of Dermatology 2013 58(3):227-231Three cases with single lesion of Alopecia mucinosa (follicular mucinosis) were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up. Two children, a boy aged 14 years and a girl aged 12 years presented themselves, each, with a single hypopigmented, hypoesthetic patch on the face. Clinically leprosy was suspected, however, skin biopsy from both patients revealed follicular mucinosis as the only pathological finding, without any granulomas. Based on clinical suspicion both...
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Rajiv JoshiVinay Gopalani Source Type: research

Skin tags: A link between lesional mast cell count/tryptase expression and obesity and dyslipidemia
Conclusions:STs seem to be related to obesity and hypertriglyceridemia. MCs with their tryptase are possibly involved in pathogenesis of STs. MC count is related to the associated factors; obesity and serum triglycerides. MC tryptase expression is a reliable method for accurate tissue MC counting. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Samar Abdallah M SalemEnas AS AttiaWesam M OsmanMarwa A El Gendy Source Type: research

Comparison of intradermal injection of autologous epidermal cell suspension vs. spraying of these cells on dermabraded surface of skin of patients with post-burn hypopigmentation
Conclusion: We did not find noticeable differences between cell spray and intradermal injection methods. Although both methods showed a limited effect on pigmentation of depigmented skin, the clinical results were not satisfactorily for both patients and clinicians. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Ahrari ImanMohamadi Ali AkbarKhosravi Maharlooei MohsenFarsi AliAttar ArminAhrari SajjadMonabati AhmadMahsa GhavipishehRahnama Leila Source Type: research

Skin infiltration of nodal peripheral T-cell lymphoma-not otherwise specified identified by skin biopsy of faint eruptions
Taro Isohisa, Noriaki Nakai, Mitsuo Kishimoto, Norito KatohIndian Journal of Dermatology 2013 58(3):247-247 (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Taro IsohisaNoriaki NakaiMitsuo KishimotoNorito Katoh Source Type: research

An electronic brachytherapy technique for treating squamous cell carcinoma in situ of the digit: a case report
Conclusions: The patient exhibited moderate redness, hyperpigmentation erythema, desquamation, and Grade 1 to 2 edema acutely (following radiation), which resolved within 1 month of the treatment. Electronic brachytherapy treatment delivery took about 6 minutes, and the total procedure time was about 15 minutes. At the median follow-up of one year, the area revealed excellent cosmesis, and there was no infection or fat necrosis, desquamation, no cancer recurrence, and no evidence of fibrosis at the last follow-up. This suggests that Electronic Brachytherapy was a viable treatment option for this particular patient. (Source...
Source: BMC Research Notes - April 15, 2013 Category: Research Authors: V ArterberyAlice Watson Source Type: research

Differential levels of elastin fibers and TGF-β signaling in the skin of Caucasians and African Americans
Conclusion: These results suggest that there are ethnic differences in the elastin fiber network and in TGF-β signaling in African American and Caucasian skin, and that African American have less UV dependent loss of elastin than Caucasian which may contribute to the different perceived aging phenotypes. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 15, 2013 Category: Dermatology Authors: J. Fantasia, C.B. Lin, C. Wiwi, S. Kaur, Y.P. Hu, J. Zhang, M.D. Southall Tags: Regular Articles Source Type: research

Cutaneous Presentation Of Chronic Lymphocytic Leukemia As Unique Extramedullar Involvement In A Patient With Normal Peripheral Blood Lymphocyte Count (Monoclonal B‐Cell Lymphocytosis)
We report a patient with no relevant past medical history who presented with cutaneous erythematous plaques. A punch biopsy showed typical CLL morphologic and immunophenotypic features. Subsequent studies revealed a normal lymphocyte count in peripheral blood, and there was no evidence of lymphadenopaty or oganomegaly. Flow cytometry demonstrated a clonal B‐cell population both in the bone marrow and peripheral blood (1.60 x 109/L) with a CLL phenotype, but it did not fulfill required criteria for CLL diagnosis. Without cutaneous involvement, this case should be classified as monoclonal B‐cell lymphocytosis. (Source: J...
Source: Journal of Cutaneous Pathology - April 13, 2013 Category: Pathology Authors: Gustavo Tapia, José‐Luis Mate, María‐José Fuente, José‐Tomás Navarro, Maria‐Teresa Fernández‐Figueras, Jordi Juncà, Carlos Ferrándiz, Aurelio Ariza Tags: Case Report Source Type: research

Atypical generalized eruptive histiocytosis clonally related to chronic myelomonocytic leukemia with loss of Y chromosome
We report an 84‐year‐old man with chronic myelomonocytic leukemia who presented with coalescing erythematous papules and plaques on the posterior neck, ear, and lower lip, followed by development of blast crisis. Skin biopsy revealed a thick band‐like dermal infiltrate of cells that exhibited morphologic features of macrophages or histiocytes and prominent elastolytic phagocytosis. These cells demonstrated a mature immunophenotype, expressing CD14 and CD68, with partial expression of CD13 but not CD1a, CD43, CD56, CD123, Langerin, or S‐100 protein. Karyotype and fluorescence in situ hybridization analyses showed lo...
Source: Journal of Cutaneous Pathology - April 13, 2013 Category: Pathology Authors: Wonwoo Shon, Margot S. Peters, Kurtis B. Reed, Rhett P. Ketterling, Ahmet Dogan, Lawrence E. Gibson Tags: Case Report Source Type: research

miRNA Normalization Candidates for qPCR in Lesional and Nonlesional Psoriatic Skin
ConclusionsThis is the first study to validate the reliability of miRNA candidates for normalization by qPCR in psoriatic skin. From this study we conclude that miR‐26a is the best candidates and better than those previously used. miR‐26a can be used for miRNA normalization in future studies with psoriatic skin.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 11, 2013 Category: Dermatology Authors: A. Langkilde, L. Raaby, C. Johansen, L. Iversen Tags: Concise Communication Source Type: research

Bilateral vertebral artery dissection, agenesis of both ICAs, and connective tissue aberrations
A 35-year-old woman presented with acute signs of stroke (appendix e-1 on the Neurology® Web site at www.neurology.org). After initial CT with angiography, MRI with time-of-flight angiography confirmed agenesis of both internal carotid arteries (ICA; figure 1A). It revealed bilateral vertebral artery (VA) dissections and ischemias in both middle artery territories (figure 1, A–E). Skin biopsy microscopy (figure 2) was consistent with ultrastructural connective tissue syndrome (uCTD), for which no further evidence was found apart from mild hypermobility of the finger joints. The underlying uCTD with structural ins...
Source: Neurology - April 8, 2013 Category: Neurology Authors: Lill, C. M., Gunther-Kunkel, K., Hoch, H., Paul, F., Grond-Ginsbach, C., Hausser, I., Zipp, F. Tags: Stroke in young adults, MRI, All Cerebrovascular disease/Stroke, Carotid artery dissection NEUROIMAGES Source Type: research

Successful Treatment of Depressed, Distensible Acne Scars Using Autologous Fibroblasts: A Multi‐Site, Prospective, Double Blind, Placebo‐Controlled Clinical Trial
ConclusionsAutologous fibroblast injections safely and effectively improved the appearance of depressed distensible acne scars. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - April 8, 2013 Category: Dermatology Authors: Girish S. Munavalli, Stacy Smith, John M. Maslowski, Robert A. Weiss Tags: Original Articles Source Type: research

Human Papillomavirus (HPV) Genotyping of Cutaneous Warts in Greek Children
The objective of this study was to determine the presence of HPV in warts in children in order to associate the virus with the disease. Sixty‐eight children with clinically diagnosed cutaneous warts were recruited. Skin biopsy samples were examined and DNA was extracted using a commercially available kit. To distinguish between the HPV types, we used a specific pair of primers to amplify the HPV DNA. Polymerase chain reaction amplification of the L1 region was followed by restriction fragment length polymorphism analysis and Luminex xMAP technology. HPV 57 was the predominant type in our study, although the detection of ...
Source: Pediatric Dermatology - April 4, 2013 Category: Dermatology Authors: Maria Giannaki, Talia Kakourou, Maria Theodoridou, Vassiliki Syriopoulou, Marios Kabouris, Eirini Louizou, George Chrousos Tags: Clinical and Laboratory Investigation Source Type: research

Diffuse cutaneous bullous mastocytosis in a newborn
Abstract Diffuse cutaneous mastocytosis is the rarest subtype of mastocytosis among those that affect children. A 7‐month‐old girl presented at birth dry and thickened skin. On the second day of life, tense blisters appeared on erythrodermic areas and during the next days spread over the face, trunk, and limbs. The skin was bright red, had a “peau d'orange” appearance, and was considerably thickened with numerous translucent and hemorrhagic blisters. A skin biopsy revealed massive infiltration of the dermis with mast cells, leading to the diagnosis of diffuse erythrodermic mastocytosis. Systemic corticosteroids wer...
Source: Dermatologic Therapy - April 3, 2013 Category: Dermatology Authors: Bartłomiej Wawrzycki, Aldona Pietrzak, Grażyna Chodorowska, Jean Kanitakis Tags: Therapeutic Hotline Source Type: research