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This page shows you the latest news and research items in this category.

Targeting HER2 in Esophageal CancerTargeting HER2 in Esophageal Cancer
Human epidermal growth factor antagonists are being tested in HER2-positive gastric and gastroesophageal junction tumors. Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Non-detection of Epstein-Barr virus and human papillomavirus in a region of high gastric cancer risk indicates a lack of a role for these viruses in gastric carcinomas
Gastric mucosa tissue was collected from patients with gastroduodenal diseases in a region of norrteastern China showing a high risk of gastric cancer incidence. The presence of EBV and HPV were assayed to investigate the relationship between gastric carcinomas and virus infection. Neither EBV nor HPV DNA was detected in tissue from the patients. The role of EBV and HPV in gastric cancer is not well understood and still needs to be clarified. (Source: Genetics and Molecular Biology)
Source: Genetics and Molecular Biology - June 17, 2013 Category: Genetics & Stem Cells Source Type: research

MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
Conclusion: Our results suggest that down-regulation of miR-204 promotes gastric cancer cell invasion by activating the SIRT1-LKB1 pathway. These data demonstrate that miR-204 plays an important role in regulating metastasis of gastric cancer, which is involved in post-transcriptional repression of SIRT1. (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Lihua ZhangXueqing WangPingsheng Chen Source Type: research

Surgery for a Bowel Obstruction
A large bowel obstruction is a potential complication of advanced cancers of the colon, ovaries or stomach. Learn more about the symptoms, treatment and risks of this blockage. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - June 14, 2013 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news

Endoscopy referral variation blamed for poor oesophageal and gastric cancer outcomes
Research from the department of gastroenterology at the University of Liverpool has found that there is a wide variation in rates of elective upper gastrointestinal endoscopy between GP practices across England. The team studied 22,488 new cases of oesophageal and gastric cancer from 6,513 general practices. Their research showed that average referral rates for endoscopy varied by 250%. (Source: NHS Networks)
Source: NHS Networks - June 14, 2013 Category: UK Health Authors: Maria Axford Source Type: news

Neoadjuvant Chemotherapy for Gastric CancerNeoadjuvant Chemotherapy for Gastric Cancer
How effective is neoadjuvant chemotherapy in the treatment of gastric cancer? This new study examines the latest research. Journal of Gastroenterology and Hepatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 12, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management.
CONCLUSION: Despite the fact that omeprazole is one of the most widely prescribed drugs internationally, clinical professionals should enhance clinical risk management on adverse DDIs associated with omeprazole and ensure safe combination use of omeprazole by rationally prescribing alternatives, checking the appropriateness of physician orders before dispensing, and performing therapeutic drug monitoring. PMID: 23745048 [PubMed] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - June 12, 2013 Category: Cancer & Oncology Authors: Li W, Zeng S, Yu LS, Zhou Q Tags: Ther Clin Risk Manag Source Type: research

Frameshift mutation of a tumor suppressor gene PALB2 in gastric and colorectal cancers with microsatellite instability
(Source: APMIS)
Source: APMIS - June 12, 2013 Category: Research Authors: Min Sung Kim, Sung Hak Lee, Nam Jin Yoo, Sug Hyung Lee Tags: Letter to the Editor Source Type: research

Protein expression status in mucosal and submucosal portions of early gastric cancers and their predictive value for lymph node metastasis
We aimed to find out predictive markers for lymph node (LN) metastasis of early gastric carcinoma (EGC) by separating evaluation of protein expression in mucosa and submucosa considering tumor heterogeneity. We selected 37 pN1–3 EGCs and depth‐ and size‐matched 31 pN0 EGCs as training set and 72 EGCs including 14 pN1–3 EGCs as test set. Protein expression for β‐catenin, E‐cadherin, N‐cadherin, galectin‐3, c‐MET, TrkB, and Ki‐67 was assessed by immunohistochemistry in mucosal (‐m) and submucosal (‐sm) portions of tumor. In the training set, Ki67‐m was higher than in Ki67‐sm (mean ± SD: 82.67�...
Source: APMIS - June 12, 2013 Category: Research Authors: Kyoung Bun Lee, Do Joong Park, Gheeyoung Choe, Hyung‐Ho Kim, Woo Ho Kim, Hye Seung Lee Tags: Original Article Source Type: research

Systematic Review of Studies Investigating Sentinel Node Navigation Surgery and Lymphatic Mapping for Gastric Cancer
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - June 11, 2013 Category: Surgery Tags: article Source Type: research

CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study
We report all index cases from Ile-de-France in which a germline CDH1 mutation has been identified. Out of 18 cases, 7 do not fulfil the HDGC-defining criteria. Three of them are women who presented initially with bilateral LBC below age 50, without personal or family history of DGC, and who subsequently developed symptomatic DGC. Discussion Our series of CDH1 mutation carriers is the largest to date and demonstrates that LBC might be the first manifestation of HDGC. A personal or family history of multiple LBCs at a young age, even without DGC, should prompt CDH1 mutation screening. It is paramount to identify mutation c...
Source: Journal of Medical Genetics - June 11, 2013 Category: Genetics & Stem Cells Authors: Benusiglio, P. R., Malka, D., Rouleau, E., De Pauw, A., Buecher, B., Nogues, C., Fourme, E., Colas, C., Coulet, F., Warcoin, M., Grandjouan, S., Sezeur, A., Laurent-Puig, P., Moliere, D., Tlemsani, C., Di Maria, M., Byrde, V., Delaloge, S., Blayau, M., Ca Tags: Breast cancer, Pancreatic cancer, Screening (oncology), Epidemiology Cancer genetics Source Type: research

Systematic Review of Studies Investigating Sentinel Node Navigation Surgery and Lymphatic Mapping for Gastric Cancer.
Abstract Abstract Evolutions in minimally invasive surgical techniques and advances in sentinel node navigation surgery (SNNS) have had considerable impact on current insights into surgical treatment of gastric cancer. Extensive data on this method of surgical application have accumulated but have been principally derived from single-institute studies. Isosulfan blue and patent blue violet have been the most frequently used dye tracers in the past; however, indocyanine green has now is increasingly popular. The double-tracer method, where dye and radioisotope tracers are used together, seems to be more effective th...
Source: Adv Data - June 11, 2013 Category: Epidemiology Authors: Can MF, Yagci G, Cetiner S Tags: J Laparoendosc Adv Surg Tech A Source Type: research

First-in-Human Phase I Dose-Escalation Study of the HSP90 Inhibitor AUY922 in Patients with Advanced Solid Tumors.
CONCLUSIONS: At the RP2D of 70 mg/m(2), AUY922 exhibited acceptable tolerability, and phase II single-agent and combination studies have been initiated in patients with HER2-positive breast, gastric, and non-small cell lung cancers. Clin Cancer Res; 19(13); 1-10. ©2013 AACR. PMID: 23757357 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - June 11, 2013 Category: Cancer & Oncology Authors: Sessa C, Shapiro GI, Bhalla KN, Britten C, Jacks KS, Mita M, Papadimitrakopoulou V, Pluard T, Samuel TA, Akimov M, Quadt C, Fernandez-Ibarra C, Lu H, Bailey S, Chica S, Banerji U Tags: Clin Cancer Res Source Type: research

Diabetes drugs may be linked to pancreatic cancer
Conclusion This article presents important concerns that glucagon-like peptide-1 (GLP-1) agonists and dipeptidylpeptidase-4 (DPP-4) inhibitors could potentially increase the risk of inflammation and cancerous changes in the pancreas. The agencies that regulate medicines in Europe and the USA are aware of these issues, and told the BMJ that their analyses show increased reporting of pancreatic cancer among people taking these types of drugs. However, the agencies note that it has not been established whether these drugs directly cause the adverse effects seen in the pancreas. Both agencies are reviewing emerging eviden...
Source: NHS News Feed - June 10, 2013 Category: Consumer Health News Tags: Medication Diabetes QA articles Source Type: news

Xeloda for Metastatic Breast Cancer
Xeloda or capecitabine is an oral chemotherapy drug that you take twice a day with water and on a full stomach. It is used to treat metastatic breast cancer, and can be taken alone or with Taxotere. Read more to learn about how Xeloda works, its side effects, and self-care tips. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - June 10, 2013 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news

Phase II/III multicentre randomised controlled trial evaluating a strategy of primary surgery and adjuvant chemotherapy versus peri-operative chemotherapy for resectable gastric signet ring cell adenocarcinomas -- PRODIGE 19 -- FFCD1103 -- ADCI002
DiscussionAs inherent chemo resistance of signet ring cell tumours and delay in definitive surgery may favour tumour progression we hypothesise that a policy of primary surgery followed by adjuvant chemotherapy will improve overall survival compared to a standard perioperative chemotherapeutic strategy. This randomised phase II/III trial is the first dedicated to this histological subtype. Whilst the development of new biomarkers and targeted therapies are awaited, the results of this trial should further help in devising individualised protocols of patient care in a tumour group whose diversity increasingly demands assess...
Source: BMC Cancer - June 10, 2013 Category: Cancer & Oncology Authors: Guillaume PiessenMathieu MessagerKarine Le MalicotWilliam RobbFrédéric Di FioreMarie GuilbertMarie MoreauVéronique ChristopheAntoine AdenisChristophe Mariette Source Type: research

Triterpenes with Cytotoxicity from the Leaves of Vernicia fordii.
Abstract Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma). ...
Source: Chemical and Pharmaceutical Bulletin - June 7, 2013 Category: Drugs & Pharmacology Authors: Pei YH, Kwon OK, Lee JS, Cha HJ, Ahn KS, Oh SR, Lee HK, Chin YW Tags: Chem Pharm Bull (Tokyo) Source Type: research

Vitamins: stop taking the pills
This article was corrected on 7 June 2013. During editing, a line in the fifth from last paragraph, beginning 'Another example is St John's wort…' was accidentally transposed, leading to the suggestion that serotonin was a medicine rather than a brain chemical.Alternative medicineHealth & wellbeingHealthCancerCancerMedical researchPharmaceuticals industryDepressionguardian.co.uk © 2013 Guardian News and Media Limited or its affiliated companies. All rights reserved. | Use of this content is subject to our Terms & Conditions | More Feeds (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - June 7, 2013 Category: Science Tags: The Guardian Depression Pharmaceuticals industry Health Medical research & wellbeing Society Extracts Features Cancer Life and style Alternative medicine Science Source Type: news

ABO Blood Group and Risk of Pancreatic Cancer: A Study in Shanghai and Meta-Analysis
Studies over 5 decades have examined ABO blood groups and risk of pancreatic cancer in Western, Asian, and other populations, though no systematic review has been published. We studied data from 908 pancreatic cancer cases and 1,067 population controls collected during December 2006–January 2011 in urban Shanghai, China, and reviewed the literature for all studies of this association. Random-effects meta-analysis provided summary odds ratio estimates according to blood group and by populations endemic versus nonendemic for cytotoxin-associated gene A (CagA)-positive Helicobacter pylori. In our Shanghai study, versus ...
Source: American Journal of Epidemiology - June 7, 2013 Category: Epidemiology Authors: Risch, H. A., Lu, L., Wang, J., Zhang, W., Ni, Q., Gao, Y.-T., Yu, H. Tags: RESEARCH-ARTICLE Source Type: research

Differences in HER2 over-expression between proximal and distal gastric cancers in the Chinese population.
CONCLUSION: HER2 over-expression in GC of Chinese patients was significantly more common in proximal than in distal GC, and significantly correlated with the Lauren intestinal type and low-grade histology in both proximal and distal GC, and with pM1 disease and male gender in distal GC. PMID: 23745034 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 7, 2013 Category: Gastroenterology Authors: Fan XS, Chen JY, Li CF, Zhang YF, Meng FQ, Wu HY, Feng AN, Huang Q Tags: World J Gastroenterol Source Type: research

Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer.
CONCLUSION: Adjuvant XELOX therapy is associated with better survival in patients after D2 dissection, but does not result in a greater survival benefit compared with FOLFOX6 therapy. PMID: 23745033 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 7, 2013 Category: Gastroenterology Authors: Wu Y, Wei ZW, He YL, Schwarz RE, Smith DD, Xia GK, Zhang CH Tags: World J Gastroenterol Source Type: research

Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins.
CONCLUSION: TSA can inhibit gastric cancer cell proliferation, which possibly activated signaling pathways in a variety of tumor-associated factors. ATP5O was obviously acetylated in AGS cells following TSA treatment. PMID: 23745024 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 7, 2013 Category: Gastroenterology Authors: Wang YG, Wang N, Li GM, Fang WL, Wei J, Ma JL, Wang T, Shi M Tags: World J Gastroenterol Source Type: research

E2F transcription factors and digestive system malignancies: How much do we know?
Abstract E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We review current knowledge on the expression of E2Fs in digestive system malignancies and its clinical implications for patient prognosis and treatment. E2F1, the most extensively studied member and the only one with prognostic value, exhibits a tumor-suppressing activity in esophageal, gastric ...
Source: World Journal of Gastroenterology - June 7, 2013 Category: Gastroenterology Authors: Xanthoulis A, Tiniakos DG Tags: World J Gastroenterol Source Type: research

Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer ¿ the RAPIDO trial
DiscussionFollowing the advances in rectal cancer management, increased focus on survival rather than only on local control is now justified. In an experimental arm, short-course radiotherapy is combined with full-dose chemotherapy preoperatively, an alternative that offers advantages compared to concomitant chemoradiotherapy with or without postoperative chemotherapy. In a multi-centre setting this regimen is compared to current standard with the aim of improving survival for patients with locally advanced rectal cancer.Trial registrationClinicalTrials.gov NCT01558921 (Source: BMC Cancer)
Source: BMC Cancer - June 7, 2013 Category: Cancer & Oncology Authors: Per NilssonBoudewijn van EttenGeke HospersLars PåhlmanCornelis van de VeldeRegina Beets-TanLennart BlomqvistJannet BeukemaEllen KapiteijnCorrie MarijnenIris NagtegaalTheo WiggersBengt Glimelius Source Type: research

GP73 is down-regulated in gastric cancer and associated with tumor differentiation
Conclusions: GP73 was normally expressed in non-tumorous gastric mucosa and down-regulated in gastric cancer. Its expression in gastric cancer was correlated with tumor differentiation. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - June 7, 2013 Category: Cancer & Oncology Authors: Le-Gao ChenHui-Ju WangHai-bo YaoTian-Pei GuanFang WuXu-Jun HeYing-Yu MaHou-Quan TaoZai-Yuan Ye Source Type: research

Red-Flag Technologies in Gastric Neoplasia
This article reviews the emerging use of enhanced endoscopic imaging technologies in the detection and management of gastric cancer. The combined use of white-light endoscopy with enhanced imaging technologies, such as magnification narrow-band imaging, chromoendoscopy, and autofluorescence endoscopy, demonstrates promise in the improved ability to detect and delineate gastric neoplasia. However, widespread clinical use is still limited, mainly because of the restricted availability of the technologies. (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - June 6, 2013 Category: Gastroenterology Authors: Susana Gonzalez Source Type: research

Hospital volume, proportion resected and mortality from oesophageal and gastric cancer: a population-based study in England, 2004-2008
Conclusions With evidence of lower short-term and longer-term mortality for patients resected in high-volume hospitals, this study supports further centralisation of oesophageal and gastric cancer surgical services in England. (Source: Gut)
Source: Gut - June 6, 2013 Category: Gastroenterology Authors: Coupland, V. H., Lagergren, J., Luchtenborg, M., Jack, R. H., Allum, W., Holmberg, L., Hanna, G. B., Pearce, N., Moller, H. Tags: Pancreatic cancer Upper GI cancer Source Type: research

Sporadic fundic gland polyps and proximal polyposis associated with gastric adenocarcinoma share a common antral G cell hyperplasia
We read with great interest the article by Worthley et al1 that recently appeared in your Journal, and the subsequent letter on the same subject.2 We would like to make some comments on this interesting topic. Worthley et al reported a new autosomal dominant syndrome that they named gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). GAPPS appears to be characterised by proximal gastric polyposis, particularly of the fundic gland type that often displays low and high grade dysplasia with early development of gastric cancer. These patients showed no evidence of colonic polyps, and other genetic syndromes w...
Source: Gut - June 6, 2013 Category: Gastroenterology Authors: Declich, P., Arrigoni, G. S., Omazzi, B., Devani, M., Tavani, E., Sioli, A., Bellone, S., Gozzini, C., Bortoli, A., Prada, A. Tags: PostScript Source Type: research

Time trends of cancer incidence and mortality in Catalonia during 1993-2007.
CONCLUSION: Among men, the decrease of incidence/mortality of tobacco-related tumors was related to a reduction of smoking prevalence. Among women, the stabilization of breast cancer incidence and the rise of lung cancer incidence are similar to that observed in most European regions. These results allow assessing the effectiveness of public health strategies and they pose new frontiers for cancer control in Catalonia. PMID: 23740137 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - June 6, 2013 Category: Cancer & Oncology Authors: Clèries R, Esteban L, Borràs J, Marcos-Gragera R, Freitas A, Carulla M, Buxó M, Puigdefàbregas A, Izquierdo A, Gispert R, Galceran J, Ribes J Tags: Clin Transl Oncol Source Type: research

Identification of tubulin beta chain, thymosin beta-4-like protein 3, and cytochrome b-c1 complex subunit 1 as serological diagnostic biomarkers of gastric cancer.
CONCLUSIONS: The pattern of proteins/peptides identified in the present work shows great potential for GC diagnosis. Deregulated proteins of tubulin beta chain, thymosin beta-4-like protein 3, and cytochrome b-c1 complex subunit 1 may be involved in the pathogenesis of GC and serve as potential serological diagnostic biomarkers. PMID: 23747515 [PubMed - as supplied by publisher] (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - June 6, 2013 Category: Cancer & Oncology Authors: Fan NJ, Li K, Liu QY, Wang XL, Hu L, Li JT, Gao CF Tags: Clin Biochem Source Type: research

The Helicobacter pylori Protein CagM is Located in the Transmembrane Channel That is Required for CagA Translocation.
Abstract Helicobacter pylori (H. pylori) is a human gastric pathogen that colonizes the stomach in more than 50 % of the world's human population. Infection with this bacterium can induce several gastric diseases ranging from gastritis to peptic ulcer and gastric cancer. Virulent H. pylori isolates harboring the cag pathogenicity island (cag PAI), which encodes a Type IV Secretion System (T4SS), form a pilus for the injection of its major virulence protein CagA into gastric cells. Several cag PAI genes have been identified as homologues of T4SS genes from Agrobacterium tumefaciens, while the other members in cag P...
Source: Current Microbiology - June 5, 2013 Category: Microbiology Authors: Ling F, Wang X, Dai D, Yu M, Chen C, Qian J, Liu C, Zhang Y, Ding J, Guan XW, Shao S Tags: Curr Microbiol Source Type: research

EphA4 is a prognostic factor in gastric cancer
Conclusion: EphA4 may play important roles in tumor progression and outcomes in patients with gastric cancer. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - June 5, 2013 Category: Pathology Authors: Kohji MiyazakiMikito InokuchiYoko TakagiKeiji KatoKazuyuki KojimaKenichi Sugihara Source Type: research

Two new neolignans from Patrinia scabra with potent cytotoxic activity against HeLa and MNK-45 cells.
Abstract Two new neolignans, patrineolignan A (1) and patrineolignan B (2), together with seven known lignans, were isolated from the 90 % aqueous EtOH extract of the roots of Patrinia scabra. Their structures were elucidated on the basis of spectroscopic data (HRESIMS, IR, 1D and 2D NMR) and comparison with literature data. The two new neolignans were evaluated in vitro for cytotoxic properties against human cervical carcinoma HeLa cell line and gastric carcinoma MNK-45 cell line using the microculture tetrazolium assay, and both 1 and 2 exhibited strongly cytotoxic activity against the two tumor cell lines. ...
Source: Archives of Pharmacal Research - June 5, 2013 Category: Drugs & Pharmacology Authors: Di L, Yan GQ, Wang LY, Ma W, Wang KJ, Li N Tags: Arch Pharm Res Source Type: research

Gastric carcinoma: imaging diagnosis, staging and assessment of treatment response.
Abstract Gastric carcinoma (GC) is one of the most common causes of cancer-related death worldwide. Surgical resection is the only cure available and is dependent on the GC stage at presentation, which incorporates depth of tumor invasion, extent of lymph node and distant metastases. Accurate preoperative staging is therefore essential for optimal surgical management with consideration of preoperative and/or postoperative chemotherapy. Multidetector computed tomography (MDCT) with its ability to assess tumor depth, nodal disease and metastases is the preferred technique for staging GC. Endoscopic ultrasonography is...
Source: Cancer Imaging - June 4, 2013 Category: Radiology Authors: Hallinan JT, Venkatesh SK Tags: Cancer Imaging Source Type: research

Changes in treatment patterns and their influence on long‐term survival in patients with stages I–III gastric cancer in The Netherlands
Studies investigating perioperative chemotherapy and/or radiotherapy changed the treatment of curable gastric cancer in The Netherlands. These changes were evaluated including their influence on survival. Data on patients diagnosed with gastric cancer from 1989 to 2009 were obtained from The Netherlands Cancer Registry. Changes over time in surgery and administration of perioperative chemotherapy, 30‐day mortality, 5‐year survival and adjusted relative excess risk (RER) of dying were analyzed with multivariable regression for cardia and noncardia cancer. In stages I and II disease, most patients underwent surgery. Sinc...
Source: International Journal of Cancer - June 4, 2013 Category: Cancer & Oncology Authors: A.E. Dassen, J.L. Dikken, C.J.H. van de Velde, M.W.J.M. Wouters, K. Bosscha, V.E.P.P. Lemmens Tags: Epidemiology Source Type: research

Silencing of Ghrelin Receptor Expression Inhibits Endometrial Cancer Cell Growth in vitro and in vivo.
Abstract Ghrelin is a 28 amino acid peptide hormone produced predominantly in the stomach, but also in a range of normal cell types and tumours, where it has endocrine, paracrine, and autocrine roles. We have previously demonstrated that ghrelin has proliferative and anti-apoptotic effects in endometrial cancer cell lines, suggesting a potential role in promoting tumour growth. In the present study, we investigated the effect of ghrelin receptor, GHSR, gene silencing in vitro and in vivo, and characterized ghrelin and GHSR1a protein expression in human endometrial tumours. GHSR gene silencing was achieved in the Is...
Source: American Journal of Physiology. Endocrinology and Metabolism - June 4, 2013 Category: Physiology Authors: Fung JN, Jeffery PL, Lee JD, Seim I, Roche D, Obermair A, Chopin LK, Chen C Tags: Am J Physiol Endocrinol Metab Source Type: research

Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers [RESEARCH]
Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated in association with UTR MS mutation. In addition, we found that 90.5% of MS mutations with deletions in gene regions occurred in UT...
Source: Genome Research - June 4, 2013 Category: Genetics & Stem Cells Authors: Yoon, K., Lee, S., Han, T.-S., Moon, S. Y., Yun, S. M., Kong, S.-H., Jho, S., Choe, J., Yu, J., Lee, H.-J., Park, J. H., Kim, H.-M., Lee, S. Y., Park, J., Kim, W.-H., Bhak, J., Yang, H.-K., Kim, S.-J. Tags: RESEARCH Source Type: research

Early Palliative Intervention for Patients with Advanced Cancer.
CONCLUSIONS: The results of this study suggested that early outpatient referral and palliative intervention leads to improvement of the outcome in patients with advanced non-small-cell lung cancer and colorectal cancer. A prospective comparative study is warranted. PMID: 23737605 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - June 4, 2013 Category: Cancer & Oncology Authors: Otsuka M, Koyama A, Matsuoka H, Niki M, Makimura C, Sakamoto R, Sakai K, Fukuoka M Tags: Jpn J Clin Oncol Source Type: research

GSK's breast cancer drug Tykerb fails in gastric cancer study
LONDON (Reuters) - GlaxoSmithKline said on Monday that its breast cancer drug lapatinib in combination with chemotherapy did not improve survival rates for patients with gastric cancer compared to the use of chemotherapy alone. (Source: Reuters: Health)
Source: Reuters: Health - June 3, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

GSK announces Phase III data for TYKERB/TYVERB® (lapatinib) in combination with chemotherapy for advanced HER2-positive gastric cancer
GlaxoSmithKline (GSK) plc today announced that its study of TYKERB/TYVERB® (lapatinib) in combination with chemotherapy in patients with HER2-positive advanced gastric cancer did not meet the primary endpoint of improved overall survival (OS) compared to chemotherapy alone. (Source: GSK news)
Source: GSK news - June 3, 2013 Category: Pharmaceuticals Source Type: news

HER2 Abnormalities Found In Many Advanced Cancers
We already know that an over-active HER2 growth factor gene features in breast and gastric cancers. Now a new study reports finding mutations and other abnormalities of the gene in 14 different advanced cancers. Massimo Cristofanilli, Director of the Jefferson Breast Center at the Kimmel Cancer Center and Thomas Jefferson University Hospital, announced the study results at an oral presentation during the annual meeting of the American Society of Clinical Oncology (ASCO), which is taking place in Chicago until Tuesday... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 3, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case–control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365 incident gastric adenocarcinoma and 1284 controls matched by center, sex, age and date of blood collection. Genotype analysis was performed for two functional polymorphisms (C282Y/rs1800562 and H63D/rs1799945) and seven tagSNPs of the HFE genomic ...
Source: Carcinogenesis - June 3, 2013 Category: Cancer & Oncology Authors: Agudo, A., Bonet, C., Sala, N., Munoz, X., Aranda, N., Fonseca-Nunes, A., Clavel-Chapelon, F., Boutron-Ruault, M. C., Vineis, P., Panico, S., Palli, D., Tumino, R., Grioni, S., Quiros, J. R., Molina, E., Navarro, C., Barricarte, A., Chamosa, S., Allen, N. Tags: Original Manuscript Source Type: research

Subsequent Epstein-Barr virus-associated gastric carcinoma shortly after chemotherapy for colonic cancer.
PMID: 23742899 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - June 3, 2013 Category: Journals (General) Authors: Huang WC, Tsai CC Tags: J Formos Med Assoc Source Type: research

The H(+)/K(+)-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells.
This study was performed to investigate the effects of TAB on H(+)/K(+)-ATPase and gastric cancer. The H(+)/K(+)-ATPase inhibitory activity was determined by gastric parietal cells. Compared to the normal control group, TAB (10, 20, 40 and 80μg/mL) inhibited the H(+)/K(+)-ATPase activity by 15.97, 16.96, 24.86 and 16.25%, respectively. In the study, 36 Kunming mice were randomly divided into six groups: control, model, TAB-L (TAB, 5mg/kg/day, i.g.), TAB-M (TAB, 20mg/kg/day, i.g ), TAB-H (TAB, 40mg/kg/day, i.g.) and omeprazole (OL, 10mg/kg/day, i.g.). All mice except control group were administrated with anhydrous alcohol ...
Source: Fitoterapia - June 3, 2013 Category: Biochemistry Authors: Zhang Q, Huang N, Wang J, Luo H, He H, Ding M, Deng WQ, Kunzou Tags: Fitoterapia Source Type: research

MiRNA‐199a‐3p: A Potential Circulating Diagnostic Biomarker for Early Gastric Cancer
ConclusionsPlasma miRNA‐199a‐3p could be a novel potential diagnostic biomarkers for EGC. J. Surg. Oncol. 2013 9999:XX–XX. © 2013 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - June 3, 2013 Category: Cancer & Oncology Authors: Chen Li, Jian Fang Li, Qu Cai, Qing Qing Qiu, Min Yan, Bing Ya Liu, Zheng Gang Zhu Tags: Research Article Source Type: research

The Use of Lentinan for Treating Gastric Cancer
(Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents))
Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) - June 1, 2013 Category: Cancer & Oncology Authors: Ina, KenjiKataoka, TakaeAndo, Takafumi Tags: Articles Source Type: research

Primary gastrointestinal lymphoma in an Egyptian district: A study using a population-based cancer registry.
CONCLUSIONS: GILs in Gharbiah, Egypt are characterized by predominance of male gender, gastric site and marginal zone histology. Survival is worse for gastric and diffuse large B-cell GILs compared to other sites and histologies. PMID: 23719408 [PubMed - in process] (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - June 1, 2013 Category: Cancer & Oncology Authors: Saber MM, Zeeneldin AA, Samra MA, Farag SA Tags: J Egypt Natl Canc Inst Source Type: research

Plasma Levels of Phospholipase A2-IIA in Patients with Different Types of Malignancies: Prognosis and Association with Inflammatory and Coagulation Biomarkers.
In conclusion, the study shows that the measurement of plasma sPLA2-IIA levels has prognostic values in patients with different types of malignancies. The association of sPLA2-IIA levels with CRP, fibrinogen, FVIII, and vWF levels supports the importance of inflammatory processes for the up-regulation of sPLA2-IIA during cancer progression. PMID: 23722320 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - June 1, 2013 Category: Pathology Authors: Menschikowski M, Hagelgans A, Schuler U, Froeschke S, Rosner A, Siegert G Tags: Pathol Oncol Res Source Type: research

Environmental and lifestyle risk factors of gastric cancer.
Abstract Effective prevention and early diagnostic strategies are the most important public health interventions in gastric cancer, which remains a common malignancy worldwide. Preventive strategies require identification and understanding of environmental risk factors that lead to carcinogenesis. Helicobacter pylori (H. pylori) is the primary carcinogen as this ancient bacterium has a complex ability to interact with its human host. Smoking and salt are strong independent risk factors for gastric cancer whereas alcohol is only a risk when it is heavily consumed. Red meat and high fat increase the risk of gastric c...
Source: Archives of Iranian Medicine - June 1, 2013 Category: Middle East Health Authors: Lee YY, Derakhshan MH Tags: Arch Iran Med Source Type: research

Gastric Cancer Mortality in a High Incidence Area: Long-term follow-up of Helicobacter pylori-related Precancerous Lesions in the General Population.
CONCLUSIONS: In this population with a high rate of H. pylori infection, age over 50 years, smoking, family history of GC, IM, AG, and in particular, an undiagnosed GU were significant independent risk factors for mortality due to GC. The assessment of a combination of these risk factors might identify individuals at risk of GC who could possibly benefit from regular surveillance. PMID: 23725067 [PubMed - in process] (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - June 1, 2013 Category: Middle East Health Authors: Boreiri M, Samadi F, Etemadi A, Babaei M, Ahmadi E, Sharifi AH, Nikmanesh A, Houshiar A, Pourfarzai F, Yazdanbod A, Alimohammadian M, Sotoudeh M Tags: Arch Iran Med Source Type: research