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This page shows you the latest news and research items in this category.

Role of Flexible Bronchoscopic Cryotechnology in Diagnosing Endobronchial Masses [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions The current study supports the view that cryotechnology is a good tool for diagnosing endobronchial masses. Cryotechnology also provides a better diagnostic specimen and has greater diagnostic accuracy than traditional forceps biopsy. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Chou, C.-L., Wang, C.-W., Lin, S.-M., Fang, Y.-F., Yu, C.-T., Chen, H.-C., Kuo, C.-H., Hsieh, M.-H., Chung, F.-T. Tags: Lung - cancer ORIGINAL ARTICLES: GENERAL THORACIC Source Type: research

The multiple roles for Sox2 in stem cell maintenance and tumorigenesis.
Abstract The Sry-containing protein Sox2 initially was known to regulate the self-renewal of the mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of stem cells in multiple adult tissues including the brain and trachea, and it is one of the key transcription factors for establishing induced pluripotent stem cells. Recently, overexpression and gene amplification of Sox2 has been associated with the development of squamous cell carcinoma in multiple tissues such as the lung and esophagus. These different roles for Sox2 involve a complicated regulatory networks consisting of microRN...
Source: Cellular Signalling - February 14, 2013 Category: Cytology Authors: Liu K, Lin B, Zhao M, Yang X, Chen M, Gao A, Liu F, Que J, Lan X Tags: Cell Signal Source Type: research

Feasibility and Safety of Nonintubated Thoracoscopic Lobectomy for Geriatric Lung Cancer Patients [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions Nonintubated thoracoscopic lobectomy is technically feasible and was as safe as thoracoscopic lobectomy performed with tracheal intubation in the geriatric lung cancer patients. Thoracoscopic lobectomy without tracheal intubation during anesthesia is a valid alternative for managing selected geriatric patients with non-small cell lung cancer. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wu, C.-Y., Chen, J.-S., Lin, Y.-S., Tsai, T.-M., Hung, M.-H., Chan, K. C., Cheng, Y.-J. Tags: Lung - cancer ORIGINAL ARTICLES: GENERAL THORACIC Source Type: research

Tracheal Adenoid Cystic Carcinoma Followed by Tracheal Squamous Cell Carcinoma:  A Case Report
DOI: 10.3779/j.issn.1009-3419.2013.01.11 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 17, 2013 Category: Cancer & Oncology Source Type: research

Rare Tracheal Tumors and Lesions Initially Diagnosed as Isolated Differentiated Thyroid Cancers
Thyroid Jan 2013, Vol. 23, No. 1: 79-83. (Source: Thyroid)
Source: Thyroid - January 4, 2013 Category: Endocrinology Tags: article Source Type: research

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is no...
Source: ActionBioscience - December 28, 2012 Category: Biology Authors: Ali Hochberg Source Type: news

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Biology Authors: Ali Hochberg Source Type: news

Speech prosthesis aspiration
A 68-year-old woman with a history of laryngeal cancer status post-laryngectomy was referred to the emergency room for an abnormal chest CT scan. The scan showed a small dense object in the distal aspect of the left mainstem bronchus at the orifice of the left lower lobe and left upper lobe bronchus consistent with an aspirated foreign body (figure 1). Upon our evaluation, the patient denied having cough, haemoptysis, shortness of breath or any history of aspiration episodes. The patient underwent bronchoscopy, which revealed a foreign object embedded in the mucosa at the carina of the left upper lobe and left lower lobe b...
Source: Emergency Medicine Journal - December 27, 2012 Category: Emergency Medicine Authors: Grosu, H. B., Esteva, F. J., Jimenez, C. A., Morice, R. C. Tags: Radiology, Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics), Ear, nose and throat/otolaryngology, Ethics, Trauma Images in emergency medicine Source Type: research

Lung Squamous Cell Carcinoma Arising in a Patient with Adult-onset Recurrent Respiratory Papillomatosis
A 75-year-old male was admitted to our hospital in December 2011 with a mass in the right upper pulmonary lobe. He was incidentally diagnosed as having tracheal papillomas 10 years ago. Bronchoscopy revealed multiple polypoid papillomas in the dorsal lesion of the trachea. Polymerase chain reaction amplification detected human papillomavirus type 11 DNA in the papilloma tissues. A computed tomography scan demonstrated the occlusion of the right superior segment bronchus with distal consolidation. Furthermore, F-18 fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography showed intense tracer uptake in ...
Source: Japanese Journal of Clinical Oncology - December 26, 2012 Category: Cancer & Oncology Authors: Hasegawa, Y., Sato, N., Niikawa, H., Kamata, S., Sannohe, S., Kurotaki, H., Sasaki, T., Ebina, A. Tags: Case Report, Original Articles Case Reports Source Type: research

Surgical Considerations in Tracheal and Carinal Resection
Surgical resection of the trachea and carina requires a highly specialized team of thoracic surgeons, anesthesiologists, and operative support staff because of the complex nature of these procedures. Improvements in the design and application of low-pressure cuffed endotracheal tubes and extensive experience in tracheal reconstruction have reduced ventilation associated airway injury and facilitated new techniques for repair. Even with these improvements, tracheal surgery for stenosis is still commonplace, as is the need for resection in cases of benign and malignant lesions of the airway. Surgical consideration of maligna...
Source: Seminars in Cardiothoracic and Vascular Anesthesia - December 11, 2012 Category: Anesthesiology Authors: Blasberg, J. D., Wright, C. D. Tags: Anesthesia and Airway Surgery Review Series Source Type: research

Yikes… spikes! Exposed tracheal cartilaginous spikes at EGD from malignant tracheoesophageal fistula
A 67-year-old woman with squamous cell carcinoma of the lung that had been diagnosed 6 months earlier, and recent biopsy-proven metastasis to her right hip, presented with 3 months of progressive dysphagia and involuntary weight loss. Physical examination revealed temporal wasting, clear lung fields, a normal abdomen, and brown stool without occult blood. The results of all laboratory studies were normal except for a hemoglobin of 8.7 g/dL, microcytic indices, and a serum albumin level of 3.4 g/dL. Videoesophagography revealed barium spilling rapidly into the left main bronchus. EGD demonstrated a tight stricture that cont...
Source: Gastrointestinal Endoscopy - November 21, 2012 Category: Gastroenterology Authors: David A. Neumann, Mitchell S. Cappell, Mihaela Batke, Mitual Amin Tags: At the Focal Point Source Type: research

Leptomeningeal carcinomatosis as initial presentation in adenocarcinoma of lung with signet ring cell features: an autopsy case report.
We report an autopsy case from a 59-year-old female who presented with intractable headache for 6 weeks and died of LMC as a result of metastatic PA-SRC. Premortem brain MRI showed nonspecific leptomeningeal enhancement. At autopsy, a tan rubbery mass was found in the hilar area of the right lung, which also surrounded the lower trachea and carotid arteries. A right posteromedial middle lobe mass was also found. Leptomeninges were slightly thickened, without discrete masses. Microscopic examination of the lung mass and leptomeninges showed solid sheets and nests of malignant cells with pleomorphic nuclei and frequent SRC f...
Source: International Journal of Clinical and Experimental Pathology - November 15, 2012 Category: Pathology Authors: Choi E, Lewis AL, Takei H, Ro JY Tags: Int J Clin Exp Pathol Source Type: research

A case of radiation-induced difficult airway in a patient with nasopharyngeal carcinoma
In conclusion, patients with nasopharyngeal carcinoma (NPC) after radiation therapy should be based on comprehensive evaluation of upper airway and obstructive condition before operation, then perform safe and effective tracheal intubation methods under spontaneous breathing. Content Type Journal ArticlePages 676-677DOI 10.1007/s10330-012-1084-8Authors Deke Li, Department of Anesthesiology, The Fifth Hospital of Wuhan, Wuhan, 430050 ChinaShiying Wang, Department of Anesthesiology, The Fifth Hospital of Wuhan, Wuhan, 430050 ChinaKun Chen, Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazho...
Source: The Chinese-German Journal of Clinical Oncology - November 14, 2012 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: research

Long-term Retention of Plutonium Nitrate in the Lungs
The long-term retention of inhaled soluble forms of plutonium raises concerns as to the potential health effects in persons working in nuclear energy or the nuclear weapons program. The distributions of long-term retained inhaled plutonium-nitrate [239Pu (NO3)4] deposited in the lungs of an accidentally exposed nuclear worker (Human Case 0269) and in the lungs of experimentally exposed beagle dogs with varying initial lung depositions were determined via autoradiographs of selected histologic lung, lymph node, trachea, and nasal turbinate tissue sections. These studies showed that both the human and dogs had a nonuniform d...
Source: Cancer Research - October 31, 2012 Category: Cancer & Oncology Authors: Nielsen, C. E., Wilson, D. A., Brooks, A. L., McCord, S. L., Dagle, G. E., James, A. C., Tolmachev, S. Y., Thrall, B. D., Morgan, W. F. Tags: Molecular and Cellular Pathobiology Source Type: research

Perioperative outcomes of esophagectomy preceded by the laparoscopic transhiatal approach for esophageal cancer
This study was designed to determine the efficacy of esophagectomy preceded by the laparoscopic transhiatal approach (LTHA) with regard to the perioperative outcomes of esophageal cancer. The esophageal hiatus was opened by hand‐assisted laparoscopic surgery, and carbon dioxide was introduced into the mediastinum. Dissection of the distal esophagus was performed up to the level of the tracheal bifurcation. En bloc dissection of the posterior mediastinal lymph nodes was performed using LTHA. Next, cervical lymphadenectomy, reconstruction via a retrosternal route with a gastric tube and anastomosis from a cervical approach...
Source: Diseases of the Esophagus - October 22, 2012 Category: Gastroenterology Authors: A. Shiozaki, H. Fujiwara, Y. Murayama, S. Komatsu, Y. Kuriu, H. Ikoma, M. Nakanishi, D. Ichikawa, K. Okamoto, T. Ochiai, Y. Kokuba, E. Otsuji Tags: Original article Source Type: research

A pain in the neck
A 47-year-old male, born in India, with genotype 3a chronic hepatitis C virus infection, a responder-relapser to 24 weeks of pegylated interferon and ribavirin therapy, successfully underwent elective liver transplantation (LT) for hepatocellular carcinoma (two lesions; 30 mm, Segment VIII, and 26 mm, Segment V) and synthetic dysfunction (MELD 8). He received a heart beating donor graft; his immunosuppression regimen consisted of tacrolimus and a reducing dose of oral corticosteroids. Microscopy of the explanted liver is shown in figure 1A. The patient underwent a 12-month protocol liver biopsy to assess eff...
Source: Gut - September 28, 2012 Category: Gastroenterology Authors: Joshi, D., Barnabas, A., Knisely, A., Barker, R., Agarwal, K. Tags: GUT Snapshot Editor ' s quiz: GI snapshot Source Type: research

Photodynamic Therapy (PDT) May Provide Effective Palliation in the Treatment of Primary Tracheal Carcinoma: A Small Case Series
Photomedicine and Laser Surgery , Vol. 0, No. 0. (Source: Photomedicine and Laser Surgery)
Source: Photomedicine and Laser Surgery - September 24, 2012 Category: Laser Surgery Tags: article Source Type: research

Metastasizing Pleomorphic Adenoma Presents Intraorally: A Case Report and Review of the Literature
We report the first, to our knowledge, example of MPA with alveolar bone metastasis. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 17, 2012 Category: ENT & OMF Authors: Matthew D. Reiland, Ioannis G. Koutlas, Raj Gopalakrishnan, Andrew G. Pearson, David L. Basi Tags: Pathology Source Type: research

Advanced esophageal cancer with an esophago-bronchial fistula successfully treated by chemoradiotherapy following esophageal bypass surgery: report of a case
This report presents the case of a patient with esophageal cancer involving the left main bronchus who underwent esophageal bypass followed by definitive chemoradiotherapy and who has achieved long-term survival without deterioration of his quality of life, in spite of the development of a malignant esophago-bronchial fistula. Content Type Journal ArticleCategory Case reportPages 1-3DOI 10.1007/s00595-012-0323-5Authors Yoshiro Aoki, Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanJun Hihara, Department ...
Source: Surgery Today - September 7, 2012 Category: Surgery Tags: Surgery Today Source Type: research

Tracheobronchial transplantation with a bioartifical nanocomposite
This proof-of-concept study describes the transplantation of a tracheobronchial airway with a stem-cell-seeded bioartifical nanocomposite in a 36-year-old man presenting with symptoms consistent of a recurrent primary mucoepidermoid cancer. He had previously been treated with debulking surgery and postoperative radiation. The tumour extension was deemed unresectable, thus, transplant with artificial biomaterial was offered. The distal trachea and proximal bronchi were resected for complete tumour removal. The airway was replaced with a synthetic bioartificial nanocomposite, tailor-made in the shape of the patient's airway....
Source: Thorax - September 7, 2012 Category: Respiratory Medicine Authors: Sritharan, K. Tags: Miscellaneous Source Type: research

Prostate cancer metastatic to the larynx: A case report.
We report a case of prostatic carcinoma that metastasized to the larynx in a 71-year-old man who presented with hoarseness and shortness of breath. Computed tomography (CT) detected a 2.9 × 3.1 × 2.6-cm mass that extended from the cricoid and arytenoid cartilages into the superior trachea. Findings on histopathology and immunohistochemistry of the laryngeal tumor were consistent with a metastasis of the patient's earlier prostate cancer. CT of the chest later detected a soft-tissue mass in the right paraspinal area and other thoracic pathology that represented metastatic disease. The patient was treated with palliative r...
Source: Ear, Nose and Throat Journal - September 1, 2012 Category: ENT & OMF Authors: Katime EE, Khurana JS, Arosarena OA Tags: Ear Nose Throat J Source Type: research

Multi‐walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats
In conclusion, intra‐pulmonary administration of MWCNTs, like asbestos, induced mesothelial proliferation potentially associated with mesothelioma development. (Source: Cancer Science)
Source: Cancer Science - August 31, 2012 Category: Cancer & Oncology Authors: Jiegou Xu, Mitsuru Futakuchi, Hideo Shimizu, David B. Alexander, Kazuyoshi Yanagihara, Katsumi Fukamachi, Masumi Suzui, Jun Kanno, Akihiko Hirose, Akio Ogata, Yoshimitsu Sakamoto, Dai Nakae, Toyonori Omori, Hiroyuki Tsuda Tags: Original Article Source Type: research

Proportion cured models applied to 23 cancer sites in norway
ConclusionCure models are useful when monitoring progress in cancer care, but must be applied and interpreted with caution. The absolute estimates of the cure proportion are speculative, and should not be calculated where cure is not medically anticipated. © 2012 Wiley Periodicals, Inc. (Source: International Journal of Cancer)
Source: International Journal of Cancer - August 28, 2012 Category: Cancer & Oncology Authors: Milada Cvancarova, Bjarte Aagnes, Sophie D. Fosså, Paul C Lambert, Bjørn Møller, Freddie Bray Tags: Epidemiology Source Type: research

Reconstruction of the (Crico)trachea for malignancy in the virgin and irradiated neck
Conclusion: Reconstruction of the trachea requires individualised techniques suited to the patient's body habitus, co-morbidity, previous treatment and the configuration of the defect. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - August 24, 2012 Category: Cosmetic Surgery Authors: Sydney Ch'ng, Carsten E. Palme, Gerald L. Wong, Markus Brunner, Bruce Ashford, John McGuinness, Jonathan R. Clark Tags: Original Articles Source Type: research

[Virtual bronchoscopy and bronchofiberoscopy--a comparison of diagnostic value in assessment of centrally localized lung tumor].
CONCLUSION: The results indicate that virtual bronchoscopy is highly sensitive and specific diagnostic method, a clinically valuable for the evaluation of lung tumor with a central location. PMID: 22370981 [PubMed - indexed for MEDLINE] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 11, 2012 Category: Respiratory Medicine Authors: Radwan-Röhrenschef P, Burakowska B Tags: Pneumonol Alergol Pol Source Type: research

Tracheal compression by the gastric tube in esophageal cancer with ankylosing spondylitis and an analysis of the mediastinal condition in 84 cases of esophagectomy: report a case
Abstract Pneumonia, recurrent nerve injury and anastomotic leakage are common complications occurring after esophagectomy. However, there have so far been few reports on tracheal compression by the gastric tube. The patient was a 66-year-old female with a history of ankylosing spondylitis and esophageal superficial squamous carcinoma treated with endoscopic mucosal resection. The new lesion was located just next to the last treated lesion. Therefore, it was difficult to treat this lesion endoscopically because of severe stenosis and scarring due to the previous treatment. Transhiatal esophagectomy was theref...
Source: Surgery Today - August 6, 2012 Category: Surgery Tags: Surgery Today Source Type: research

Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression
Abstract NET family members have recently emerged as important players in the development of multiple structures, from the trachea of fly larvae to the vertebrate eye and human breast cancers. However, their mechanisms of action are still poorly understood, and we lack a detailed characterization of their functional domains, as well as gene expression patterns ‐ particularly in adult mammals. Here we present a characterization of human NLZ1/ZNF703 (NocA‐like zinc finger 1/Zinc finger 703), one of the two human NET family member genes. We show that the gene is ubiquitously expressed in adult human and mouse tissues, tha...
Source: Journal of Cellular Biochemistry - August 6, 2012 Category: Biochemistry Authors: Isabel Pereira‐Castro, Ângela M. Sousa Costa, Maria José Oliveira, Inês Barbosa, Ana Sofia Rocha, Luisa Azevedo, Luís Teixeira da Costa Tags: Article Source Type: research

Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer
Conclusion: Given that POSS-PCU has already been used in human in first-in-man studies as trachea, lacrimal duct, bypass graft and other organs, our long-term goal is to take POSS-PCU coated CNTs to clinical studies to address the treatment of cancer by optimizing its therapeutic index and increasing its specificity via antibody conjugation. Results: Functionalizing (or "coating") CNTs with POSS-PCU confers biocompatibility and increase the amount of heat energy generated, by enhancing dispersion. Here we demonstrate that POSS-PCU-functionalized MWNTs act synergistically together when exposed to NIR to thermally ablate can...
Source: Journal of Nanobiotechnology - July 31, 2012 Category: Nanotechnology Authors: Aaron TanSeyed Yazdan MadaniJayakumar RajadasGiorgia PastorinAlexander Seifalian Source Type: research

Does the effect of gender modify the relationship between deprivation and mortality?
Conclusions: We believe our results were obtained using a more robust methodology. First off, we have built a better index that allows us to directly collect the variability of contextual variables without having to use arbitrary weights. Secondly, we have solved two major problems that are present in spatial ecological regressions, i.e. those that use spatial data and, consequently, perform a spatial adjustment in order to obtain consistent estimators. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - July 30, 2012 Category: Consumer Health News Authors: Natalia SalcedoMarc SaezBasili BragulatCarme Saurina Source Type: research

Single institutional analysis of trends over 45 years in etiology of vocal fold paralysis
Conclusion: The increase in postoperative cases of paralysis may be caused by the increasing frequency of operations for many diseases, due to the progress of medical techniques in recent years. The decrease in idiopathic cases may be related to the advances of diagnostic devices such as CT and MRI. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - July 27, 2012 Category: ENT & OMF Authors: Shingo Takano, Takaharu Nito, Noriko Tamaruya, Miwako Kimura, Niro Tayama Tags: Laryngology Source Type: research

Repair of Nonmalignant Postlaryngectomy Pharyngotracheal Fistula [CASE REPORTS]
We present 2 rare cases. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 26, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Kucejko, R. J., Luu, Q., Calhoun, R. F., Cooke, D. T. Tags: Trachea and bronchi CASE REPORTS Source Type: research

Long-term results of curative intraluminal high dose rate brachytherapy for endobronchial carcinoma
Conclusions: ILBT combined with or without EBRT might be a curative treatment option in inoperable endobronchial carcinoma patients with tolerable complication. (Source: Radiation Oncology)
Source: Radiation Oncology - July 23, 2012 Category: Cancer & Oncology Authors: Hidemasa KawamuraTakeshi EbaraHiroyuki KatohTomoaki TamakiHitoshi IshikawaHideyuki SakuraiTakashi Nakano Source Type: research

Successful esophageal bypass surgery in a patient with a large tracheoesophageal fistula following endotracheal stenting and chemoradiotherapy for advanced esophageal cancer: case report
Abstract A 63-year-old man with esophageal achalasia for more than 20 years complained of respiratory distress. He was admitted as an emergency to the referral hospital three months previously. Computed tomography revealed tracheobronchial stenosis due to advanced esophageal cancer with tracheal invasion. He underwent tracheobronchial stenting and chemoradiotherapy. A large tracheoesophageal fistula (TEF) developed after irradiation (18 Gy) and chemotherapy, and he was unable to eat. Thereafter, he was referred to our hospital, where we performed esophageal bypass surgery using a gastric condu...
Source: Esophagus - July 18, 2012 Category: Gastroenterology Tags: Esophagus Source Type: research

Primary mucoepidermoid carcinoma of the trachea in a child
We report the case of a 9-year-old boy with mucoepidermoid carcinoma of the trachea that was preoperatively diagnosed as an intraluminal polypoid mass arising from the trachea and extending into the right main bronchus. A complete resection of the tumour with reconstruction and end-to-end anastomosis of the trachea was performed. The patient is now, 24 months after surgery, free of disease. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - July 16, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Papiashvilli, M., Ater, D., Mandelberg, A., Sasson, L. Tags: Thoracic Source Type: research

Nucleotide variability and linkage disequilibrium patterns in the porcine MUC4 gene
Conclusions: Chinese and Western breeds have similar nucleotide diversity but evolve divergently in theMUC4 region. Western breeds exhibited unusual low LD extent at the MUC4 locus,reflecting the complexity of nucleotide variability of pig genome. The finding suggests thathigh density (e.g. 1SNP/10 kb) markers are required to capture the underlying causal variantsat such regions. (Source: BMC Genetics - Latest articles)
Source: BMC Genetics - Latest articles - July 13, 2012 Category: Genetics & Stem Cells Authors: Ming YangBin YangXueming YanJing OuyangWeihong ZengHuashui AiJun RenLusheng Huang Source Type: research

An Unusual Case of Carcinoma Ex Pleomorphic Adenoma of the Parotid Metastasizing to the Mandible: Case Report and Review of the Literature
This article reports a case of CXPA of the right parotid gland with noncontiguous involvement of the mandibular body. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - July 9, 2012 Category: ENT & OMF Authors: Mohammed Nadershah, Ahmed Alshadwi, Andrew Salama Tags: Surgical Oncology and Reconstruction Source Type: research

Surface layer‐preserving photodynamic therapy (SPPDT) in a subcutaneous mouse model of lung cancer
ConclusionSPPDT was able to damage tumor beneath the superficial normal tissue layer, which included tracheal cartilage in the mouse model. The thickness control of SPPDT was provided by controlling laser pulse intensity. SPPDT is a new technology, whose future potential is unknown. The initial clinical application of this technology could be endoscopic treatment (e.g., palliative therapy of thoracic malignancies via bronchoscopy). Lasers Surg. Med. 44: 500–507, 2012. © Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)
Source: Lasers in Surgery and Medicine - June 29, 2012 Category: Laser Surgery Authors: Masayoshi Kawakubo, Keisuke Eguchi, Tsunenori Arai, Koichi Kobayashi, Michael R. Hamblin Tags: Basic Science Source Type: research

Pharyngolaryngo-Esophagectomy with Laparoscopic Gastric Pull-Up: A Reappraisal for the Pharyngoesophageal Junction Cancer
Conclusions Laparoscopic surgery allows a minimally invasive gastric tailoring and tubulization and transhiatal esophageal dissection and represents a valuable alternative for intestinal reconstruction after PLE. CT scan showing a large hypopharynx carcinoma involving cervical lymph nodes and cervical esophagus Content Type Journal ArticleCategory Head and Neck OncologyPages 1-1DOI 10.1245/s10434-012-2375-6Authors Cristiano Huscher, Surgery, University of Molise, Isernia, ItalyAndrea Mingoli, Surgery P. Valdoni, La Sapienza University, Rome, ItalyAndrea Mereu, General Surgery, San Giov...
Source: Annals of Surgical Oncology - June 14, 2012 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: research

Comparison of data from the Norwegian Patient Register and the Cancer Registry of Norway.
Comparison of data from the Norwegian Patient Register and the Cancer Registry of Norway. Tidsskr Nor Laegeforen. 2012 Jun 12;132(11):1336-1340 Authors: Bakken IJ, Gystad SO, Christensen OO, Huse UE, Larønningen S, Nygård J, Holmstrøm L, Johannesen TB, Møller B, Larsen IK Abstract Background. The regulations of the Norwegian Patient Register (NPR) and the Cancer Registry of Norway (CRN) allow linkage of the registries for evaluation of completeness and validity of data. Material and method. Data on patients registered as having C18 (colon cancer), C19-C21 (cancer of the rectum, rectosigmoid junction or ...
Source: Tidsskrift for den Norske Laegeforening - June 12, 2012 Category: Journals (General) Authors: Bakken IJ, Gystad SO, Christensen OO, Huse UE, Larønningen S, Nygård J, Holmstrøm L, Johannesen TB, Møller B, Larsen IK Tags: Tidsskr Nor Laegeforen Source Type: research

Virtual 3-D 18F-FDG PET/CT panendoscopy for assessment of the upper airways of head and neck cancer patients: a feasibility study
Conclusion Virtual 18F-FDG PET/CT panendoscopy of the upper airways is technically feasible and can detect pharyngeal and laryngeal malignancies. This new tool can aid in the complete evaluation of the subglottic space in intubated patients and may be used for planning optical panendoscopies, biopsies and surgery in the future. Content Type Journal ArticleCategory Short CommunicationPages 1-6DOI 10.1007/s00259-012-2152-6Authors Christian Buchbender, Medical Faculty, Department of Diagnostic and Interventional Radiology, University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, GermanyJon Treffert, Mo...
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 6, 2012 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: research

Thoracoscopic Mediastinal Lymph Node Dissection for Lung Cancer
In lung cancer, mediastinum lymphatic spread occurs. We review our technique and experience of thoracoscopic mediastinal lymphnode dissection (MLND). Between 1997 and 2011, 992 patients with primary lung cancer underwent thoracoscopic major pulmonary resection with MLND. Initially we used a combination of electrocautery and clips to divide blood vessels and lymphatic channels; our current technique relies on a vessel sealing system (VSS) which is expeditious and leads to less lymphorrhea. Furthermore, dissection of station 7 nodes is performed after each main bronchus or right intermediate bronchus is taped with a 0 silk s...
Source: Seminars in Thoracic and Cardiovascular Surgery - May 28, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Atsushi Watanabe, Jyunnji Nakazawa, Masahiro Miyajima, Ryo Harada, Shinji Nakashima, Tohru Mawatari, Tetsuya Higami Tags: Techniques My Way Source Type: research

Non-circumferential tracheal resection with muscle flap reconstruction for adenoid cystic carcinoma
We describe a technique of non-circumferential tracheal resection performed to treat ACC arising from the lower membranous trachea adjacent to the carina. The tumor was resected while preserving the tracheo-carinal cartilage. A silicone Y-stent was placed at the bifurcation to ensure airway patency before closing the defect. The airway defect, measuring 4 × 2.5 cm, was closed using an autologous pericardial patch and pedicled latissimus dorsi muscle flap. These procedures were technically easy, and no postoperative airway complication occurred. Content Type Journal ArticleCategory Case ReportPages...
Source: General Thoracic and Cardiovascular Surgery - May 22, 2012 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: research

Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer.
Abstract Lung cancer was induced in Sprague-Dawley rats by a single intra-tracheal instillation of 9,10-dimethybenz(a)anthracene (DMBA) and evaluated the anti-angiogenic action of etoricoxib, which is a selective cyclooxygenase-2 (COX-2) inhibitor. The animals were divided into four groups. Group 1 (Control) received 0.9% (w/v) normal saline intra-tracheal and 0.5% (w/v) carboxymethyl cellulose per oral daily as the vehicle of the drug, Group 2 received DMBA (20mg/kg) intra-tracheal once, Group 3 received a daily oral dose of etoricoxib (0.6mg/kg bw) in addition to the DMBA while Group 4 received etoricoxib alone. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 10, 2012 Category: Drugs & Pharmacology Authors: Nadda N, Vaish V, Setia S, Sanyal SN Tags: Biomed Pharmacother Source Type: research

Tracheobronchial reconstructions with bronchoplastic closure: An alternative method in treatment of bronchogenic carcinoma involving the carina or tracheobronchial angle
Conclusions: Tracheobronchial reconstruction using bronchoplastic closure might be a reasonable option for closing massive central airway defects for advanced bronchogenic carcinoma involving the tracheobronchial angle or carina, avoiding tracheal sleeve pneumonectomy with limited excision of the lateral wall of the trachea or carina. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - May 7, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Wen-xin He, Bing-qiang Han, Ming Liu, Peng Zhang, Jiang Fan, Nan Song, Ge-ning Jiang Tags: General Thoracic Surgery Source Type: research

Extra-anatomic pulmonary artery bypass for main pulmonary artery stenosis caused by neoplasm
We present here such a case, that of a patient who had adenoid cystic carcinoma of trachea that recurred at pulmonary artery near the pulmonary valve and who underwent surgical management with an extra-anatomic pulmonary artery bypass. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - May 2, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Ryo Aeba, Hiroaki Nomori, Ryohei Yozu Tags: Online Only: Case Reports Source Type: research

Management of dyspnea in a patient with lung cancer.
Abstract Nine months prior, S.P., a 64-year-old woman, was diagnosed with stage IV non-small cell lung cancer with distant metastases to the bone. Her large tumor burden had compressed both her trachea and esophagus several months earlier, leading to gastrostomy-tube placement for nutrition and tracheostomy for airway management. Palliative radiation was used to shrink the tumor size and allow for removal of the tracheostomy tube, leaving an open area covered with gauze in the middle of her neck-a reminder of her previous struggles with breathing. Unfortunately, the cancer progressed and S.P. was admitted to the ho...
Source: Oncology Nursing Forum - May 1, 2012 Category: Nursing Authors: Bonk AK Tags: Oncol Nurs Forum Source Type: research

Definitive radiotherapy for unresected adenoid cystic carcinoma of the trachea.
We report on two patients with unresectable disease who were treated with definitive radiotherapy: one using conventional photons and one treated with a combination of photon and proton beams. Both patients were treated to a dose of 80 Gy with acceptable toxicities and objective clinical and radiographic response. The patient treated with conventional photons has no evidence of recurrent disease at 5 years; the patient treated with protons has continued evidence of response without evidence of disease recurrence 11 months after treatment. PMID: 22553266 [PubMed - in process] (Source: Chest)
Source: Chest - May 1, 2012 Category: Respiratory Medicine Authors: Bonner Millar LP, Stripp D, Cooper JD, Both S, James P, Rengan R Tags: Chest Source Type: research

Fast-Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma: Randomized Controlled Clinical Trial
Conclusions Fast-track surgery accelerates clinical recovery and improves postoperative immunity after elective open surgery for colorectal carcinoma. Content Type Journal ArticlePages 1-7DOI 10.1007/s00268-012-1606-0Authors Dongjie Yang, Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou, 510080 ChinaWeiling He, Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou, 510080 ChinaSheng Zhang, Department of Gastrointestinal an...
Source: World Journal of Surgery - April 24, 2012 Category: Surgery Tags: World Journal of Surgery Source Type: research

Appalachian Residents’ Perspectives on New U.S. Cigarette Warning Labels
We examined the reactions to and attitudes about the new labels among residents of Appalachian Ohio, a region with a high smoking prevalence. We conducted focus groups with Appalachian Ohio residents between July and October 2011. Participants included healthcare providers (n = 30), community leaders (n = 26), parents (n = 28), and young adult men ages 18-26 (n = 18). Most participants supported the addition of the new labels to U.S. cigarette packages, though many were unaware of the labels prior to the focus groups. Participants did not think the labels would be effective in pro...
Source: Journal of Community Health - April 23, 2012 Category: Global & Universal Tags: Journal of Community Health Source Type: research