Typhoid Vaccine This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Oral immunization with an attenuated salmonella gallinarum mutant as a fowl typhoid vaccine with a live adjuvant strain secreting the B subunit of Escherichia coli heat-labile enterotoxin
Conclusion: Our results suggest that immunization with the LTB-adjuvant strain JOL1229 can significantly increase the immune response, and provide efficient protection against FT with no side effects on body weight, egg production, or egg contamination. (Source: BMC Veterinary Research - Latest articles)
Source: BMC Veterinary Research - Latest articles - May 6, 2013 Category: Veterinary Research Authors: Byung JeonRahul NandreJohn Lee Source Type: research

Typhoid Fever Affects Young International Travelers Typhoid Fever Affects Young International Travelers
Children traveling to countries where typhoid fever is endemic have the highest risk of contracting the disease; families should be counseled on the availability of vaccines. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 3, 2013 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Humanitarian crisis grows
MSF Canada’s executive director Stephen Cornish recently returned from a two-week visit to Syria, Lebanon and Turkey. We talked to him about the humanitarian situation inside Syria, as well as the situation of Syrian refugees in neighbouring countries. Can you describe some of the healthcare needs you witnessed? We usually only hear about people killed by shelling and mortars. But there are many silent casualties of the conflict. Many civilians die because they don’t have access to healthcare. People with treatable diseases such as diabetes or cancer can no longer get the treatment they need. An increasing number o...
Source: MSF News - April 18, 2013 Category: Global & Universal Tags: Syria NEWS Violence Source Type: news

Comprehensive Assignment of Roles for Salmonella Typhimurium Genes in Intestinal Colonization of Food-Producing Animals
by Roy R. Chaudhuri, Eirwen Morgan, Sarah E. Peters, Stephen J. Pleasance, Debra L. Hudson, Holly M. Davies, Jinhong Wang, Pauline M. van Diemen, Anthony M. Buckley, Alison J. Bowen, Gillian D. Pullinger, Daniel J. Turner, Gemma C. Langridge, A. Keith Turner, Julian Parkhill, Ian G. Charles, Duncan J. Maskell, Mark P. Stevens Chickens, pigs, and cattle are key reservoirs of Salmonella enterica, a foodborne pathogen of worldwide importance. Though a decade has elapsed since publication of the first Salmonella genome, thousands of genes remain of hypothetical or unknown function, and the basis of colonization of reservoir h...
Source: PLoS Genetics - April 18, 2013 Category: Genetics & Stem Cells Authors: Roy R. Chaudhuri et al. Source Type: research

Modelling typhoid risk in Dhaka Metropolitan Area of Bangladesh: the role of socio-economic and environmental factors
Conclusions: The typhoid occurrence/risk prediction equation was used to develop the first risk map showing areas of Dhaka Metropolitan Area whose inhabitants are at greater or lesser risk of typhoid infection. This, coupled with seasonal information on typhoid incidence also reported in this paper, has the potential to advise public health professionals on developing prevention strategies such as targeted vaccination. (Source: International Journal of Health Geographics)
Source: International Journal of Health Geographics - March 16, 2013 Category: Global & Universal Authors: Robert CornerAshraf DewanMasahiro Hashizume Source Type: research

Effect of travel distance on household demand for typhoid vaccines: implications for planning
SUMMARY Typhoid fever causes millions of illnesses and hundreds of thousands of deaths yearly. Vaccinations would mitigate this problem, but the users would probably have to pay some or most of the cost. Several willingness‐to‐pay studies have assessed the effect of price on private demand to provide a basis for financial planning of campaigns, but the effect of travel distance, which is a potentially important determinant of demand, has not been studied. This paper thus has two objectives: (i) conduct a willingness‐to‐pay survey to assess the effects of distance, price and other variables on the private demand for...
Source: The International Journal of Health Planning and Management - March 12, 2013 Category: Health Management Authors: Dohyeong Kim, Donald T. Lauria, Christine Poulos, Baiqing Dong, Dale Whittington Tags: Research Article Source Type: research

Formative Research and Development of an Evidence-Based Communication Strategy: The Introduction of Vi Typhoid Fever Vaccine Among School-Aged Children in Karachi, Pakistan
(Source: Journal of Health Communication)
Source: Journal of Health Communication - February 23, 2013 Category: Global & Universal Authors: Pach, AlfredTabbusam, GhurnataKhan, M. ImranSuhag, ZamirHussain, ImtiazHussain, EjazMumtaz, UzmaHaq, Inam ulTahir, RehmanMirani, AmjadYousafzai, AishaSahastrabuddhe, SushantOchiai, R. LeonSoofi, SajidClemens, John D.Favorov, Michael O.Bhutta, Zulfiqar A. Source Type: research

Lassa fever: why there are more public health questions than answers
The Lassa virus can wipe out entire families. It is transmitted by rats and is endemic to west Africa – so why is there no vaccine? Lina Moses shares her experiences of working in Sierra LeoneI'm in a village in eastern Sierra Leone staring at a row of dead rats snared in branches, leaves and grass. The contraptions are called funnel traps, or tolei in the local Mende dialect. We're hoping these devices and other easily accessible or producible materials will lower the rodent populations in villages sufficiently to prevent Lassa fever.With a DfID-funded project called Wash (water, sanitation health), Facility Sierra Leon...
Source: Guardian Unlimited Science - February 21, 2013 Category: Science Tags: Guardian Professional World news Infectious diseases Malaria and infectious diseases Medical research Microbiology Sierra Leone Editorial Global development professionals network Policy and advocacy Africa Science Source Type: news

A human IgG anti-Vi reference for Salmonella typhi with weight-based antibody units assigned.
Abstract Recent data showing the high incidence of typhoid fever in young children, the demonstration of safety and efficacy of a Vi conjugate for this age group, the safety and similar immunogenicity in infants when administrated concurrently with EPI vaccines, together with the interests of manufacturers and investigators in studying such conjugate vaccines prompted us to prepare a human IgG anti-Vi standard to facilitate this work. Volunteers were injected with an investigational Vi-recombinant Pseudomonas aeruginosa exoprotein A (Vi-rEPA) conjugate vaccine. Plasmas with the highest levels of IgG anti-Vi were po...
Source: Vaccine - February 16, 2013 Category: Allergy & Immunology Authors: Szu SC, Hunt S, Xie G, Robbins JB, Schneerson R, Gupta R, Zhao Z, Tan X Tags: Vaccine Source Type: research

Reply to 'apropos "evaluation of serological diagnostic tests for typhoid Fever in papua new Guinea using a composite reference standard"'.
PMID: 23359462 [PubMed - in process] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - January 30, 2013 Category: Allergy & Immunology Authors: Greenhill A, Siba V, Horwood P Tags: Clin Vaccine Immunol Source Type: research

Apropos "evaluation of serological diagnostic tests for typhoid Fever in papua new Guinea using a composite reference standard".
PMID: 23359461 [PubMed - in process] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - January 30, 2013 Category: Allergy & Immunology Authors: Arya SC, Agarwal N Tags: Clin Vaccine Immunol Source Type: research

Vaccine update: January 2013
Source: Department of Health (DH) Area: News The November 2012 issue of the Vaccine Update bulletin is now available. The current issue highlights the following: . Flu surges in North America . Catch it. Bin it. Kill it campaign . Clarification on codes for flu vaccination uptake monitoring . Vaccine wastage . Migrant health in the primary care setting, with a focus on infectious diseases - training videos . Vaccine supply (hepatitis A and typhoid) . Green Book chapter update (Source: NeLM - News)
Source: NeLM - News - January 21, 2013 Category: Drugs & Pharmacology Source Type: news

Doctors warn travellers of vaccine shortages for the potentially deadly typhoid fever
There is a UK shortage of the vaccine, following a recall by pharmaceutical company of 88 per cent of its stock. Typhoid fever can be found throughout the developing world, including India and Indonesia. (Source: the Mail online | Health)
Source: the Mail online | Health - December 26, 2012 Category: Consumer Health News Source Type: news

Holidaymakers at risk as doctors run out of typhoid vaccine
Supply crisis sparked by manufacturer's recall – 700,000 people already injected could be affectedTravellers jetting off to exotic climes this winter face a scramble to get immunised against typhoid, because of a UK shortage of vaccine against the potentially fatal disease.Immunisation against typhoid fever is usually provided free of charge on the NHS but many GP surgeries across the country say they have run out. A number of travel clinics, which charge for vaccinations, are in the same situation.The shortage is the knock-on effect of a recall in October by Sanofi Pasteur MSD of 16 batches of its injectable typhoid vac...
Source: Guardian Unlimited Science - December 25, 2012 Category: Science Authors: Haroon Siddique Tags: Infectious diseases Pharmaceuticals industry News guardian.co.uk Medical research Microbiology Travel UK news Medical advice for travellers Business Science Source Type: news

DTaP poliovirus vaccine/hepatitis a typhoid vaccine/yellow fever vaccine: Lymphoedema in an elderly patient with breast cancer: case report
(Source: Reactions)
Source: Reactions - December 17, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Vaccine Update for October 2012
Source: Department of Health (DH) Area: News The October 2012 edition of the Vaccine Update bulletin is now available. The current edition highlights the following: - Uptake of flu vaccinations in the under 65s at risk - Whooping cough vaccination and pregnant women - Supply of pre-school boosters (Repevax - dTaP/IPV and Infanrix - DTaP/IPV) for the infant programme - Immunisation news - Green book updates - Updates on the availability of typhoid, hepatitis A and rabies vaccines (Source: NeLM - News)
Source: NeLM - News - November 12, 2012 Category: Drugs & Pharmacology Source Type: news

Real history: Vaccines not responsible for halting infectious diseases of 20th century
A common misconception about vaccines purports that they are the primary reason why infectious disease rates saw a rapid and steady decline throughout the early-to-mid 20th century. But an honest look at the figures reveals that diseases like polio, typhoid, measles... (Source: NaturalNews.com)
Source: NaturalNews.com - November 8, 2012 Category: Consumer Health Advice Source Type: news

Microbiology: Typhoid fever in a mouse
Nature 491, 7423 (2012). doi:10.1038/491162d A mouse model of typhoid fever could help scientists to develop vaccines against a disease that infects some 20 million people and kills more than 220,000 worldwide each year.Mice are normally immune to the bacterium Salmonella typhi, which causes typhoid fever in humans. (Source: Nature)
Source: Nature - November 7, 2012 Category: Research Tags: Research Highlights Source Type: research

First Mouse Model Of Typhoid Fever
Columbia University Medical Center (CUMC) researchers have created the first true mouse model of typhoid infection. The development promises to advance the study of typhoid and the creation of new vaccines against the infection, which remains a major health threat in developing countries. The paper was published in the online edition of the journal Cell. "Vaccines are the most practical solution for preventing typhoid in the Third World. Unfortunately, existing typhoid vaccines are only modestly effective, leaving millions of people vulnerable to infection... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2012 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

Animal model of typhoid fever could lead to better vaccines
The first mouse model of the common bacterial disease typhoid fever is reported in a new study. Because the animals show human-like symptoms and respond positively to immunization, they could be used to develop more effective vaccines against the deadly pathogen. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 25, 2012 Category: Science Source Type: news

Scientists create first mouse model of typhoid fever
Researchers have created the first true mouse model of typhoid infection. The development promises to advance the study of typhoid and the creation of new vaccines against the infection, which remains a major health threat in developing countries. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 25, 2012 Category: Science Source Type: news

Scientists create first mouse model of typhoid fever
(Columbia University Medical Center) Researchers have created the first true mouse model of typhoid infection. The development promises to advance the study of typhoid and the creation of new vaccines against the infection, which remains a major health threat in developing countries. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 25, 2012 Category: Global & Universal Source Type: news

An animal model of typhoid fever could lead to better vaccines
(Cell Press) The first mouse model of the common bacterial disease typhoid fever is reported in a study published by Cell Press Oct. 25 in the journal Cell. Because the animals show human-like symptoms and respond positively to immunization, they could be used to develop more effective vaccines against the deadly pathogen. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 25, 2012 Category: Infectious Diseases Source Type: news

Immunological Evaluation of Vi-Capsular Polysaccharide of Salmonella typhi Vaccine by Serum Bactericidal Assay.
Abstract Salmonella typhi Vi-capsular polysaccharide (Vi-CPS) is a reliable vaccine candidate against typhoid fever. Since there is no animal model for Salmonella typhi fever to evaluate protective efficacy of Vi-CPS vaccine, serum bactericidal assay (SBA) is a recommended golden standard to evaluate its potency. Vi-CPS was extracted from Salmonella typhi Ty6S (CSBPI-B-191) by modified Gotschlich method. 50 µg of purified Vi-CPS was injected intramuscularly into three groups of five rabbits, Groups 2 and 3 received additional booster doses of 50 µg Vi-CPS on days 15, 30 and 45, respectively. Group's sera were tes...
Source: Journal of Medical Microbiology - October 25, 2012 Category: Microbiology Authors: Ahmadi H, Tabaraie B, Maleknia S, Shapouri R, Nejati M, Pour Mirza Gholi F, Hedayati MH, Sadati M, Zahednia S, Sharifat Salmani A Tags: J Med Microbiol Source Type: research

Typhoid vaccine a useless dud, health authorities admit
The United Kingdom's Medicines and Healthcare Products Regulatory Agency (MHRA) has announced that a typhoid vaccine given to more than 700,000 people in the past two years was partially ineffective. The vaccine in question, Sanofi Pasteur's Typhim Vi, is designed... (Source: NaturalNews.com)
Source: NaturalNews.com - October 18, 2012 Category: Consumer Health Advice Source Type: news

Live oral typhoid vaccine Salmonella Typhi Ty21a - A surrogate vaccine against non-typhoid salmonellae?
CONCLUSIONS: Intestinal antibodies against O-antigens protect against NTS in animal experiments. Ty21a was found to elicit intestinal immune responses cross-reactive with NTS strains sharing O-antigens with Ty21a. These include the most common NTS, Salmonella Enteritidis and Typhimurium. The data suggest that Ty21a may have cross-protective efficacy against numerous NTS strains. PMID: 23084770 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - October 16, 2012 Category: Allergy & Immunology Authors: Kantele A, Pakkanen SH, Siitonen A, Karttunen R, Kantele JM Tags: Vaccine Source Type: research

An urgent recall of Typhim Vi typhoid vaccine is being conducted in Australia.
(Source: Reactions)
Source: Reactions - October 14, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Typhoid vaccine recall highlights importance of record-keeping
The recent recall of a typhoid vaccine highlights the importance of accurate record keeping in general practice, it is claimed read more (Source: Nursing in Practice)
Source: Nursing in Practice - October 11, 2012 Category: Nursing Authors: lnaughton Tags: Travel health Editor ' s pick Source Type: news

NHS Choices assessment of press reports about 'dud' typhoid fever vaccine fears
Source: NHS Choices Area: News NHS Choices has conducted a quality assessment of a press report in the Daily Telegraph stating that "as many as 700,000 travellers are at risk of typhoid fever because of 'dud batches of a vaccine.' The news is based on a drug alert issued by the MHRA which advises that 16 batches of the typhoid vaccine, Typhim Vi, are being recalled by the manufacturer. The alert has been issued over concerns about the effectiveness of some batches of the vaccine due to an error in the manufacturing process. There are concerns that some patients vaccinated with Typhim Vi since January 2011 may n...
Source: NeLM - News - October 11, 2012 Category: Drugs & Pharmacology Source Type: news

10.11.12 -- Sanofi Recalls Typhoid Vaccine Batches
10/11/12 Pharmaceutical Online Newsletter (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - October 10, 2012 Category: Pharmaceuticals Source Type: news

Safety alert issued over typhoid vaccine
The Medicines and Healthcare products Regulatory Agency has issued a drug alert advising healthcare professionals that 16 batches of the vaccine Typhim Vi have been recalled. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - October 10, 2012 Category: Nursing Source Type: news

UK Says Sanofi, Merck Recall Some Typhoid Vaccine BatchesUK Says Sanofi, Merck Recall Some Typhoid Vaccine Batches
Sanofi Pasteur MSD, the vaccine joint venture of Sanofi and Merck, has recalled some batches of its typhoid vaccine because of concerns about effectiveness. News Alerts (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 9, 2012 Category: Consumer Health News Tags: Infectious Diseases News Alert Source Type: news

Typhoid fever vaccine recalled
The Health Protection Agency (HPA) is aware the Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug alert to healthcare professionals advising them that the manufacturer Sanofi Pasteur MSD has recalled 16 batches of their typhoid vaccine, Typhim Vi. (Source: Health Protection Agency)
Source: Health Protection Agency - October 9, 2012 Category: UK Health Source Type: news

'Dud' typhoid fever vaccine fears
As many as 700,000 travellers are at risk of typhoid fever because of ‘dud batches of a vaccine’, The Daily Telegraph reports. The news is based on a drug alert issued by the UK drug regulator, the Medicines and Healthcare products Regulatory Agency (MHRA). The alert to healthcare professionals advises that 16 batches of the typhoid vaccine, Typhim Vi, are being recalled by the manufacturer. The alert has been issued over concerns about the effectiveness of some batches of the vaccine due to an error in the manufacturing process. There are concerns that some patients vaccinated with Typhim Vi since January 2011 may n...
Source: NHS News Feed - October 9, 2012 Category: Consumer Health News Tags: QA articles Source Type: news

UK says Sanofi, Merck recall some typhoid vaccine batches
LONDON (Reuters) - Sanofi Pasteur MSD, the vaccine joint venture of Sanofi and Merck & Co, has recalled some batches of its typhoid vaccine because of concerns about effectiveness, Britain's drug regulator said on Monday. (Source: Modern Medicine)
Source: Modern Medicine - October 9, 2012 Category: Journals (General) Source Type: news

'Under-powered' typhoid vaccine recalled
Travellers vaccinated against typhoid might not be fully protected against the disease, because batches of the most widely-used jab have been found to be under-powered. (Source: Telegraph Health)
Source: Telegraph Health - October 8, 2012 Category: Consumer Health News Tags: typhim Vi Sanofi Pasteur MSD typhoid vaccine Source Type: news

700,000 travellers 'at risk of typhoid due to dud jab'
More than 700,000 people who thought they were protected against typhoid may be vulnerable to the disease, because of a dud batches of a vaccine. (Source: Telegraph Health)
Source: Telegraph Health - October 8, 2012 Category: Consumer Health News Tags: typhim Vi Sanofi Pasteur MSD typhoid vaccine Source Type: news

Typhoid vaccine failure warning
Hundreds of thousands of people recently immunised against typhoid may not have full protection because of a dud vaccine that has now been recalled, warn experts. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 8, 2012 Category: Consumer Health News Source Type: news

UK says Sanofi, Merck recall some typhoid vaccine batches
LONDON (Reuters) - Sanofi Pasteur MSD, the vaccine joint venture of Sanofi and Merck & Co, has recalled some batches of its typhoid vaccine because of concerns about effectiveness, Britain's drug regulator said on Monday. (Source: Reuters: Health)
Source: Reuters: Health - October 8, 2012 Category: Consumer Health News Tags: healthNews Source Type: news

Typhoid vaccine batches recalled
Drugs manufacturer Sanofi Pasteur has recalled a number of batches of their typhoid vaccine. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug alert to healthcare professionals advising them of the recall of 16 batches of Typhim Vi. read more (Source: Nursing in Practice)
Source: Nursing in Practice - October 8, 2012 Category: Nursing Authors: abrewerton Tags: Latest News Source Type: news

Sanofi Recalls Batches of Typhoid Vaccine; not as Potent as Should be
From Canadian Press DataFile (October 4, 2012) TORONTO _ Vaccine maker Sanofi Pasteur is recalling several batches of its typhoid fever vaccine over concerns the doses may not be as potent as they should be. The company says the batches of the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 5, 2012 Category: Pharmaceuticals Source Type: news

The Reliability of Pre‐travel History to Decide on Appropriate Counseling and Vaccinations: A Prospective Study
ConclusionsPre‐travel history does not adequately reflect what travelers do. However, difference between recommendations for the actual versus intended travel plans was only clinically significant for the need for rabies vaccine. Particular attention during pre‐travel health counseling should focus on the risk of rabies, the need to avoid close contact with animals and to seek care for post‐exposure prophylaxis following an animal bite. (Source: Journal of Travel Medicine)
Source: Journal of Travel Medicine - September 4, 2012 Category: Infectious Diseases Authors: Isabelle A. Rossi, Blaise Genton Tags: ORIGINAL ARTICLE Source Type: research

Comparative proteome and transcriptome analyses of wild-type and live vaccine strains of Salmonella enterica serovar Gallinarum.
In this study, we examined the molecular characteristics, which might provide better insight into attenuation of SG 9R, by comparing its proteome and transcriptome with those of two wild-type strains (287/91 and 06Q110). Proteins present in wild-type strains but absent in SG 9R were identified by two-dimensional gel electrophoresis and MALDI-TOF MS. Genes up- or down-regulated in SG 9R compared to wild-type strains were identified using an expression array. The proteome analysis identified nine proteins absent in SG 9R of which one protein had relevance to virulence. The transcriptome analysis revealed 24 up-regulated and ...
Source: Vaccine - August 31, 2012 Category: Allergy & Immunology Authors: Kang MS, Kwon YK, Kim HR, Oh JY, Kim MJ, An BK, Shin EG, Kwon JH, Park CK Tags: Vaccine Source Type: research

Vaccine Update - August 2012
Source: Department of Health (DH) Area: News The August edition of the Vaccine Update bulletin is now available. The current edition highlights the following: Immunisation News . Girls denied HPV vaccinations on religious grounds . JCVI human papillomavirus (HPV) call for evidence . Updates to Green Book chapter 19 Vaccine Supply . Deliveries of vaccines during the Paralympics . Typhoid and hepatitis A vaccines . Movianto UK deliveries over the August Bank Holiday (Source: NeLM - News)
Source: NeLM - News - August 24, 2012 Category: Drugs & Pharmacology Source Type: news

Vi antigen of Salmonella enetrica serovar Typhi — biosynthesis, regulation and its use as vaccine candidate
Abstract Vi capsular polysaccharide (Vi antigen) was first identified as the virulence antigen of Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. The presence of Vi antigen differentiates S. Typhi from other serovars of Salmonella. Vi antigen is a linear polymer consisting of α-1,4-linked-N-acetyl-galactosaminuronate, whose expression is controlled by three chromosomal loci, namely viaA, viaB and ompB. Both viaA and viaB region are present on Salmonella Pathogenicity Island-7, a large, mosaic, genetic island. The viaA region encodes a positive regulator and the via...
Source: Central European Journal of Biology - August 3, 2012 Category: Biology Tags: Central European Journal of Biology Source Type: research

Molecular modelling, docking and interaction studies of human-plasmogen and salmonella enolase with enolase inhibitors.
In this study, molecular modelling of enolase of Salmonella has been accomplished in silico by comparative modelling; we have then analyzed Human alpha enolase which is a homodimer and serves on epithelial cells with our model. Both Structures were docked by D-tartronate semialdehyde phosphate (TSP) and 3-aminoenolpyruvate phosphate (AEP) enolase inhibitors. Our study shows that salmonella enolase and human enolase have different active sites in their structure. This will help in development of new ligands, more suitable for inhibiting bacterial survival inside host as vaccines for typhoid fever are not fully protective. T...
Source: Bioinformation - August 2, 2012 Category: Bioinformatics Authors: Chauhan DS, Chandra S, Gupta A, Singh TR Tags: Bioinformation Source Type: research

Cross-reactive gut-directed immune response against Salmonella enterica serovar Paratyphi A and B in typhoid fever and after oral Ty21a typhoid vaccination.
CONCLUSIONS: These immunological data provide evidence consistent with previous reports describing certain levels of cross-protective efficacy of Ty21a against paratyphoid fever. Controlled studies are needed to evaluate cross-protective efficacy. In the current situation where paratyphoid fever is emerging and no vaccines are available, any level of cross-protective capacity is valuable. PMID: 22858557 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - August 2, 2012 Category: Allergy & Immunology Authors: Pakkanen SH, Kantele JM, Kantele A Tags: Vaccine Source Type: research

Safety of live, attenuated oral vaccines in HIV-infected Zambian adults: Oral vaccines in HIV.
CONCLUSIONS: No evidence was found of adverse events following administration of these three vaccines, except for late episodes of diarrhoea which may not be attributable to vaccination. Our data do not support the need for a prohibition on oral administration of live, attenuated vaccines to all HIV infected adults, though further work on severely immunocompromised adults and children are required. PMID: 22789509 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 10, 2012 Category: Allergy & Immunology Authors: Banda R, Yambayamba V, Lalusha BD, Sinkala E, Kapulu MC, Kelly P Tags: Vaccine Source Type: research

Efficacy of Baptisia Tinctoria in the Treatment of Typhoid: Its Possible Role in Inducing Antibody Formation
Typhoid is one of the most serious infectious bacterial diseases in third world countries. It is usually treated by traditional antibiotics but due to the appearance of antibiotic resistant strains physicians opt for phyto products and other alternative medicines for the treatment of typhoid. Baptisia, an extract from indigo plant root, has been proved to be highly effective ultradilute medicine for the treatment of typhoid; however, the mode of action of the ultradilute extract is uncertain. Due to the antigenic variations of Salmonella it seems to induce immuno system by activating both T and B cells by the formation of ...
Source: Journal of Complementary and Integrative Medicine - July 2, 2012 Category: Complementary Medicine Tags: Infectious Disease Source Type: research

Vaccine Safety Improved By Sensitive Test
Salmonella Typhi (S. Typhi) is the causative agent of typhoid fever, a serious health threat resulting in some 22 million new cases yearly and approximately 217,000 fatalities. A number of novel vaccine candidates using live attenuated strains of Salmonella are being developed, but care must be taken to ensure the bacteria are not excreted into the environment following vaccination. Karen Brenneman and her colleagues at Arizona State University's Biodesign Institute have been examining ways to detect the presence of S. Typhi in stool following inoculation with various vaccine strains... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 29, 2012 Category: Consumer Health News Tags: Tropical Diseases Source Type: news