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Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Increased Th1 serum cytokines (IL-2, IL-12 and interferon-[gamma]) and IL-1ra levels are associated with AA regardless of disease severity or the presence of atopy. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: N. Barahmani, A. Lopez, D. Babu, M. Hernandez, S. E. Donely, M. Duvic Source Type: journals

Five-year experience in the treatment of alopecia areata with DPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Diphencyprone is an effective and safe treatment of extensive AA. A long period of therapy is needed and will increase the percentage of responders especially in alopecia totalis and universalis. Maintenance therapy is recommended to reduce the risk of relapse. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - September 7, 2009 Category: Dermatology Authors: BM El-Zawahry, DA Bassiouny, A Khella, NS Zaki Source Type: journals

Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Topical bexarotene 1% application is well tolerated and possibly effective. A randomized placebo-controlled trial should be conducted. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 16, 2009 Category: Dermatology Authors: Rakhshandra Talpur, Jenny Vu, Roland Bassett, Victor Stevens, Madeleine Duvic Tags: Original Articles Source Type: journals

History of atopy or autoimmunity increases risk of alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This analysis revealed that a history of atopy and autoimmune disease was associated with an increased risk of AA and that the results were consistent for both the severe subtype of AA (ie, alopecia totalis and alopecia universalis) and the localized subtype (ie, AA persistent). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - July 16, 2009 Category: Dermatology Authors: Nazila Barahmani, Matthew B. Schabath, Madeleine Duvic, National alopecia Areata Registry Tags: Original Articles Source Type: journals

Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UV...
Source: Archives of Dermatological Research - March 20, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Vitamin D-Dependent Rickets Type II: Report of a Novel Mutation in the Vitamin D Receptor Gene.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present the clinical findings on a family which exhibited the typical clinical features of hereditary vitamin D-resistant rickets in two siblings. In addition, molecular analysis of the vitamin D receptor gene was performed by sequencing all coding exons. The cardinal findings in the index patient were alopecia totalis, renal tubular acidosis, mild generalized aminoaciduria, refractory rickets, high alkaline phosphatase, and hyperparathyroidism. Other routine biochemical tests were within normal limits, but 1+ glycine was detected in his urine. Skin biopsy results were compatible with alopecia areata. A ...
Source: Archives of Iranian Medicine - May 1, 2008 Category: Middle East Health Authors: Shafeghati Y, Momenin N, Esfahani T, Reyniers E, Wuyts W Tags: Arch Iran Med Source Type: journals

Cochrane review: Interventions for alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to the findings of a systematic review conducted by the Cochrane Collaboration, few treatments for alopecia areata (AA) have been well evaluated in randomised, controlled trials. AA is a disorder where there is a loss of hair with no scarring to the affected area. It can affect the entire scalp (alopecia totalis) or cause loss of all body hair (alopecia universalis). Its cause is not yet fully understood, and although it can start at any age, it will most commonly develop before 20 years of age. Although in many cases it can be a self-limiting condition, the hair loss will often have a severe social and emotion...
Source: NeLM Headline News - April 22, 2008 Category: Drugs & Pharmacology Source Type: organizations

Alopecia areata progressing to totalis/universalis in non-insulin dependent diabetes mellitus (type II): Failure of dexamethasone-cyclophosphamide pulse therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sehgal Virendra N, Bhattacharya Sambit N, Sharma Sonal, Srivastava Govind, Aggarwal Ashok KIndian Journal of Dermatology, Venereology and Leprology 2008 74(2):171-173 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - April 2, 2008 Category: Dermatology Authors: Sehgal Virendra N, Bhattacharya Sambit N, Sharma Sonal, Srivastava Govind, Aggarwal Ashok K Source Type: journals

The effect of methylprednisolone pulse-therapy plus oral cyclosporine in the treatment of alopecia totalis and universalis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the therapeutic and side effects of pulse-therapy with methylprednisolone combined with oral cyclosporine in severe alopecia areata, defined as alopecia totalis and universalis. Six patients with alopecia totalis and 12 patients with alopecia universalis were referred to our center. The patients were treated with monthly intravenous methylprednisolone in doses of 500 mg for three days and oral cyclosporine (2.5 mg/kg/day) for five to eight months. Responses were categorized as: "adequate" (i.e., hair regrowth on > or =70% of the affected area) and "inadequate" (i.e., hair regr...
Source: Archives of Iranian Medicine - January 1, 2008 Category: Middle East Health Authors: Shaheedi-Dadras M, Karami A, Mollaei F, Mollaei M, Moravvej H, Moravej T, Malekzad F Tags: Arch Iran Med Source Type: journals

In vivo levels of IL-4, IL-10, TGF-β1 and IFN-γ mRNA of the peripheral blood mononuclear cells in patients with alopecia areata in comparison to those in patients with atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, AA might be induced by an aberrant expression of IFN-γ in individuals whose PBMC produce low amounts of IFN-γ and TGF-β1. Further analysis is therefore required to investigate the phenotypes of the population in PBMC with or without reference to regulatory T cells. Content TypeJournal Article JournalArchives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696 (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - September 22, 2006 Category: Dermatology News Source Type: journals

Acute alopecia totalis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From a group of 1,189 AA patients seen in our dermatology unit, thirteen (3 males, 10 females) experienced hair shedding that started profusely and diffusely over the entire scalp. They were under observation for about 5 years, histopathology and trichograms being performed in all instances. The mean age of the patients was 26.7 years. It took only 2.3 months on average from the onset of hair shedding to total denudation of the scalp. The trichogram at the time of diffuse shedding showed that about 80% had dystrophic roots and the remaining 20% had telogen roots. Histopathological findings and exclamation mark hairs we...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - March 14, 2006 Category: Dermatology News Authors: Choi HJ, Ihm CW Source Type: journals