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Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Increased Th1 serum cytokines (IL-2, IL-12 and interferon-[gamma]) and IL-1ra levels are associated with AA regardless of disease severity or the presence of atopy. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: N. Barahmani, A. Lopez, D. Babu, M. Hernandez, S. E. Donely, M. Duvic Source Type: journals

Satoyoshi syndrome with unusual skeletal abnormalities and parental consanguinityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 26-year-old Mexican woman, a product of consanguineous parents with clinical characteristics of SS. Our patient, also showed skeletal anomalies not previously reported that seems to be a coincidental finding. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - October 15, 2009 Category: Genetics & Stem Cells Authors: C.A. Venegas-Vega, M.R. Rivera-Vega, S. Cuevas-Covarrubias, J. Orozco, S. Kofman-Alfaro Source Type: journals

Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes seven Arab families, in which 18 patients had APS1. In addition to the cardinal features of APS1, some patients exhibited alopecia, diabetes mellitus, nephrocalcinosis and other phenotypes associated with APS1. DNA sequencing of the AIRE gene of patients from this study identified four novel and one recurrent mutation. These mutations likely result in loss of AIRE function in the patients. In addition, it was noted that the non-pathogenic c.834C> G mutation (rs1800520, encoding for p.Ser278Arg) occurs with high incidence in the AIRE gene of Arab individuals. Furthermore, this investigation demonstra...
Source: Clinical Genetics - September 14, 2009 Category: Genetics & Stem Cells Authors: Faiyaz-Ul-Haque M, Bin-Abbas B, Al-Abdullatif A, Abdullah Abalkhail H, Toulimat M, Al-Gazlan S, Almutawa A, Al-Sagheir A, Peltekova I, Al-Dayel F, Zaidi S Tags: Clin Genet Source Type: journals

Five-year experience in the treatment of alopecia areata with DPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Diphencyprone is an effective and safe treatment of extensive AA. A long period of therapy is needed and will increase the percentage of responders especially in alopecia totalis and universalis. Maintenance therapy is recommended to reduce the risk of relapse. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - September 7, 2009 Category: Dermatology Authors: BM El-Zawahry, DA Bassiouny, A Khella, NS Zaki Source Type: journals

Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Topical bexarotene 1% application is well tolerated and possibly effective. A randomized placebo-controlled trial should be conducted. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 16, 2009 Category: Dermatology Authors: Rakhshandra Talpur, Jenny Vu, Roland Bassett, Victor Stevens, Madeleine Duvic Tags: Original Articles Source Type: journals

History of atopy or autoimmunity increases risk of alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This analysis revealed that a history of atopy and autoimmune disease was associated with an increased risk of AA and that the results were consistent for both the severe subtype of AA (ie, alopecia totalis and alopecia universalis) and the localized subtype (ie, AA persistent). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - July 16, 2009 Category: Dermatology Authors: Nazila Barahmani, Matthew B. Schabath, Madeleine Duvic, National alopecia Areata Registry Tags: Original Articles Source Type: journals

The lived experience of alopecia areata: a qualitative study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study explored experiences of individuals living with alopecia areata (AA) and alopecia universalis (AU) and investigated their accounts of adjusting to, and coping with, such conditions. Whilst previous research has primarily focused on the adverse psychosocial impact of alopecia, this investigation used Interpretive Phenomenological Analysis to provide a more holistic perspective. Biographical interviews were undertaken with 12 participants (7 women; 5 men) diagnosed with alopecia for periods ranging between 2 and 49 years. Results revealed that strategies used by participants evolved over time and that there were c...
Source: Body Image - May 31, 2009 Category: Psychiatry & Psychology Authors: Welsh N, Guy A Tags: Body Image Source Type: journals

ICD: Steroid-Sparing Treatment Shows Promise for Alopecia (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PRAGUE (MedPage Today) -- Methotrexate-based, steroid-sparing therapy has induced hair growth in more than 90% of patients with alopecia universalis, according to an ongoing clinical evaluation. (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - May 29, 2009 Category: Dermatology Source Type: news

Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UV...
Source: Archives of Dermatological Research - March 20, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Adalimumab: Alopecia areata universalis: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 4 (Source: Reactions Weekly)
Source: Reactions Weekly - December 7, 2008 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Adalimumab: Alopecia areata universalis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - December 7, 2008 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Alopecia Areata Universalis during Treatment of Rheumatoid Arthritis with Anti-TNF-a Antibody (Adalimumab)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatology 2008;217:380 (DOI:10.1159/000162180) (Source: Dermatology)
Source: Dermatology - October 14, 2008 Category: Dermatology Source Type: journals

Atrichia with papular lesions: a report of three novel human hairless gene mutations and a revision of diagnostic criteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrichia with papular lesions is a rare autosomal recessive condition characterized by complete irreversible hair loss during the first months of life and papules that appear during early childhood. Atrichia with papular lesions is frequently misdiagnosed as alopecia universalis, despite increasing reports of its prevalence and the presence of well-defined diagnostic criteria. Most cases of atrichia with papular lesions have been reported in consanguineous families residing in small geographical regions, but the increasing number of sporadic cases of unrelated individuals suggests that atrichia with papular lesions is ...
Source: Acta Derm Venereol A... - August 20, 2008 Category: Dermatology Authors: Yip L, Horev L, Sinclair R, Zlotogorski A Tags: Acta Derm Venereol Source Type: journals

Alopecia universalis with twenty-nail dystrophy (trachyonychia).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 43-year-old man presented with long-standing trachyonychia of all 20 nails, which worsened after the onset of alopecia universalis 18 months ago. Trachyonychia can be associated with alopecia universalis although the treatment strategies of both conditions differ. The principle of treating trachyonychia may involve regulating the differentiation of keratinocytes and/or reducing inflammation in the nail fold or nail matrix while treatment of alopecia universalis involves immunomodulation. PMID: 18627760 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 18, 2008 Category: Dermatology Authors: Chien P, Kovich OI Tags: Dermatol Online J Source Type: journals

Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe ...
Source: Journal of Diabetes and Its Complications - July 9, 2008 Category: Endocrinology Authors: Thrasivoulos G. Tzellos, Dimitrios K. Tahmatzidis, Aimilios Lallas, Kiriaki Apostolidou, Dimitrios G. Goulis Tags: Case Reports Source Type: journals

Cochrane review: Interventions for alopecia areataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to the findings of a systematic review conducted by the Cochrane Collaboration, few treatments for alopecia areata (AA) have been well evaluated in randomised, controlled trials. AA is a disorder where there is a loss of hair with no scarring to the affected area. It can affect the entire scalp (alopecia totalis) or cause loss of all body hair (alopecia universalis). Its cause is not yet fully understood, and although it can start at any age, it will most commonly develop before 20 years of age. Although in many cases it can be a self-limiting condition, the hair loss will often have a severe social and emotion...
Source: NeLM Headline News - April 22, 2008 Category: Drugs & Pharmacology Source Type: organizations

Adalimumab: Alopecia universalis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - April 21, 2008 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Adalimumab: Alopecia universalis: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 4 (Source: Reactions Weekly)
Source: Reactions Weekly - April 19, 2008 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Alopecia areata progressing to totalis/universalis in non-insulin dependent diabetes mellitus (type II): Failure of dexamethasone-cyclophosphamide pulse therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sehgal Virendra N, Bhattacharya Sambit N, Sharma Sonal, Srivastava Govind, Aggarwal Ashok KIndian Journal of Dermatology, Venereology and Leprology 2008 74(2):171-173 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - April 2, 2008 Category: Dermatology Authors: Sehgal Virendra N, Bhattacharya Sambit N, Sharma Sonal, Srivastava Govind, Aggarwal Ashok K Source Type: journals

The effect of methylprednisolone pulse-therapy plus oral cyclosporine in the treatment of alopecia totalis and universalis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the therapeutic and side effects of pulse-therapy with methylprednisolone combined with oral cyclosporine in severe alopecia areata, defined as alopecia totalis and universalis. Six patients with alopecia totalis and 12 patients with alopecia universalis were referred to our center. The patients were treated with monthly intravenous methylprednisolone in doses of 500 mg for three days and oral cyclosporine (2.5 mg/kg/day) for five to eight months. Responses were categorized as: "adequate" (i.e., hair regrowth on > or =70% of the affected area) and "inadequate" (i.e., hair regr...
Source: Archives of Iranian Medicine - January 1, 2008 Category: Middle East Health Authors: Shaheedi-Dadras M, Karami A, Mollaei F, Mollaei M, Moravvej H, Moravej T, Malekzad F Tags: Arch Iran Med Source Type: journals

Alopecia areata universalis in an infantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Alopecia areata should be included in the differential diagnosis of generalized alopecia presenting at or shortly after birth. For purposes of genetic counseling and prognosis, it is crucial that a correct diagnosis be made. Content Type Journal ArticleCategory Case ReportsDOI 10.1007/BF02737867Authors Jo Anne LaRow, Albany Medical College A-81 Division of Dermatology and Dermatopathology 12208 Albany NY USAJudith Mysliborski, Capital District Dermatology 12208 Albany New YorkI. Paul Rappaport, Aesthetic Laser & Skin Care Center 12866 Saratoga Springs New YorkGuy A. Rouleau, Montreal Genera...
Source: Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology - October 30, 2007 Category: Dermatology Tags: Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology Source Type: journals

Peginterferon-[alpha]-2b/ribavirin: Alopecia universalis: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 23 (Source: Reactions Weekly)
Source: Reactions Weekly - September 11, 2007 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Peginterferon--2b/ribavirin: Alopecia universalis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 9, 2007 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Reversible alopecia universalis secondary to PEG-interferon [alpha]-2b and ribavirin combination therapy in a patient with chronic hepatitis C virus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 817DOI: 10.1097/MEG.0b013e32818b27e5Authors: Kartal, Elif Doyuk; Alpat, Saygn Nayman [latin dotless i]; Ozgunes, Ilhan; Usluer, Gaye (Source: European Journal of Gastroenterology & Hepatology)
Source: European Journal of Gastroenterology & Hepatology - August 15, 2007 Category: Gastroenterology Tags: Abstract HTML PDF (104 K) Source Type: journals

Alopecia areata universalis and acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 6, 2007 Category: Hematology Authors: D.P. Busuttil Source Type: journals

Effect of homeopathic treatment of 60 Japanese patients with chronic skin disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The psychological, physical and psychosomatic symptoms and effects of chronic skin diseases are inextricable. Individualized homeopathic treatment can provoke a good response in patients with chronic skin disease; therefore, the holistic approach used in homeopathy may be a useful strategy alongside conventional treatment. PMID: 17544862 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - June 6, 2007 Category: Complementary Medicine Authors: Itamura R Tags: Complement Ther Med Source Type: journals

Adalimumab: Alopecia areata universalis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - January 18, 2007 Category: Drugs & Pharmacology Source Type: journals

CORRESPONDENCE: Development of Alopecia Areata Universalis in a Patient Receiving AdalimumabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Dermatology)
Source: Archives of Dermatology - December 18, 2006 Category: Dermatology News Authors: Garcia Bartels, N., Lee, H.-H., Worm, M., Burmester, G.-R., Sterry, W., Blume-Peytavi, U. Source Type: journals

Alopecia universalis in down syndrome: Response to therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sethuraman Gomathy, Malhotra Amit K, Sharma Vinod KIndian Journal of Dermatology, Venereology and Leprology 2006 72(6):454-455 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - December 17, 2006 Category: Dermatology News Authors: Sethuraman Gomathy, Malhotra Amit K, Sharma Vinod K Source Type: journals

Peginterferon/ribavirin: Alopecia universalis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - December 11, 2006 Category: Drugs & Pharmacology Source Type: journals

Contiguous gene syndrome of holoprosencephaly and hypotrichosis simplex: Association with an 18p11.3 deletionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with a unique combination of features, including microcephaly; mental retardation; poorly developed frontal lobes; hypoplastic pituitary gland; hypothyroidism; alopecia universalis; single maxillary central incisor; taurodontism; median palatal ridge; longitudinally grooved nails; and scoliosis. His unbalanced karyotype was found to be 45,XY,der(15;18)(q10;q10). The constellation of anomalies appears to represent a contiguous gene syndrome caused, at least in part, by deletion of TGIF and the gene responsible for hereditary hypotrichosis simplex. The phenotype of our patient differs other reported patie...
Source: American Journal of Medical Genetics Part A - September 29, 2006 Category: Stem Cells Authors: Piranit N. Kantaputra, Chanin Limwongse, Chintana Tochareontanaphol, Apiwat Mutirangura, Umnat Mevatee, Verayuth Praphanphoj Source Type: journals

What are the possible causes of alopecia universalis in an otherwise fit and healthy 42 year old woman with normal thyroid function tests?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
You may find it helpful to refer to a US guideline on adult hair disorders [1] which contains a comprehensive section on disorders causing hair loss. The link to this guideline is given in the reference section below. (Source: NLH Question Answering Service)
Source: NLH Question Answering Service - June 15, 2006 Category: Primary Care Source Type: organizations

Disorders of Hair: Alopecia AreataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alopecia areata is typically characterized by patchy hair loss; however, involvement can vary from a single patch on the scalp or elsewhere to total body baldness (alopecia universalis).ACP Medicine Reference (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - June 8, 2006 Category: Dermatology News Source Type: info